The Relationship Between Prenatal, Perinatal, and Postnatal Factors and ADHD: The Role of Nutrition, Diet, and Stress

IF 1.8 4区 心理学 Q3 DEVELOPMENTAL BIOLOGY
Lubna Al-Gailani, Ali Al-Kaleel
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引用次数: 0

Abstract

Attention-Deficit Hyperactive Disorder (ADHD) is a neurobehavioral syndrome affecting children aged 6–17 with symptoms manifesting before age 12. ADHD presents heterogeneously and is associated with various psychiatric disorders. The cause remains elusive, but genetic and environmental factors, brain region maturation delays, and neurotransmitter dysregulation are implicated. Effective treatment requires a multi-disciplinary approach, primarily involving pharmacological and behavioral intervention. Stimulants like methylphenidate and amphetamines are first-line medications, but non-stimulants may be considered for some patients. However, stimulants face challenges related to misuse, dependence, and long-term tolerability issues. The etiology of ADHD involved genetic predisposition, environmental influences, and prenatal, perinatal, and postnatal factors. Prenatal causes encompass maternal diet, alcohol consumption, viral infections, and stress. Postnatal factors include head trauma, meningitis, toxin, nutritional deficiencies, as well as iodine deficiency and hypothyroidism. The gut microbiome's role in ADHD is emerging, influencing neurodevelopment through microbiota–gut–brain axis. Understanding these diverse etiological factors is essential for comprehensive ADHD management.

产前、围产期和产后因素与多动症之间的关系:营养、饮食和压力的作用。
注意力缺陷多动障碍(ADHD)是一种神经行为综合征,多发于 6-17 岁的儿童,症状在 12 岁前显现。注意力缺陷多动障碍的表现多种多样,并与各种精神疾病有关。其病因仍然难以捉摸,但遗传和环境因素、脑区成熟延迟和神经递质失调都与之有关。有效的治疗需要多学科方法,主要包括药物和行为干预。哌醋甲酯和安非他明等兴奋剂是一线药物,但有些患者也可考虑使用非兴奋剂。然而,兴奋剂面临着滥用、依赖性和长期耐受性等方面的挑战。多动症的病因涉及遗传易感性、环境影响以及产前、围产期和产后因素。产前因素包括母亲的饮食、饮酒、病毒感染和压力。产后因素包括头部创伤、脑膜炎、毒素、营养缺乏以及碘缺乏和甲状腺功能减退。肠道微生物组在多动症中的作用正在显现,通过微生物组-肠道-大脑轴影响神经发育。了解这些不同的致病因素对于全面治疗多动症至关重要。
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来源期刊
Developmental psychobiology
Developmental psychobiology 生物-发育生物学
CiteScore
4.20
自引率
18.20%
发文量
125
审稿时长
6-12 weeks
期刊介绍: Developmental Psychobiology is a peer-reviewed journal that publishes original research papers from the disciplines of psychology, biology, neuroscience, and medicine that contribute to an understanding of behavior development. Research that focuses on development in the embryo/fetus, neonate, juvenile, or adult animal and multidisciplinary research that relates behavioral development to anatomy, physiology, biochemistry, genetics, or evolution is appropriate. The journal represents a broad phylogenetic perspective on behavior development by publishing studies of invertebrates, fish, birds, humans, and other animals. The journal publishes experimental and descriptive studies whether carried out in the laboratory or field. The journal also publishes review articles and theoretical papers that make important conceptual contributions. Special dedicated issues of Developmental Psychobiology , consisting of invited papers on a topic of general interest, may be arranged with the Editor-in-Chief. Developmental Psychobiology also publishes Letters to the Editor, which discuss issues of general interest or material published in the journal. Letters discussing published material may correct errors, provide clarification, or offer a different point of view. Authors should consult the editors on the preparation of these contributions.
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