Meconium as an Analyte for Androgen Exposure: Analysis Through Varying Maternal-Fetal Biomarkers

IF 1.8 4区心理学 Q3 DEVELOPMENTAL BIOLOGY

Developmental psychobiology Pub Date : 2024-10-08 DOI:10.1002/dev.22550

Nicole Knudsen, Stacey Tang, Sylvie Lauzon, Supriya Dhaurali, Nathaniel W. Snyder, Kristin M. Voegtline

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引用次数: 0

Abstract

Meconium, the first stool produced by neonates, has been used as an analyte for exogenous fetal exposures. However, few studies have investigated the relationship between meconium and androgen exposure in utero. Here, we examine the associations of testosterone and dehydroepiandrosterone (DHEA) across maternal antenatal salivary testosterone, cord blood, meconium, and infant salivary testosterone. A total of 47 women with singleton, uncomplicated pregnancies, and their infants were included in this study. Participants were recruited from an academic obstetric clinic. Maternal saliva was collected at 36-weeks’ gestation. Cord blood and meconium were collected at birth. Infant salivary testosterone was collected at 1 and 4 weeks of age. Multivariate model results showed that meconium testosterone was associated with neonatal testosterone at 1 (F = 5.62, p = 0.029) and 4 weeks (F = 4.28, p = 0.048) postnatal age; no sex differences were detected. This study suggests meconium is a valuable tool for evaluating endogenous androgen exposure and should be used in future studies to investigate the fetal hormonal milieu.

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作为雄激素暴露分析物的胎粪：通过不同的母胎生物标志物进行分析

胎粪是新生儿排出的第一批粪便，一直被用作胎儿外源性暴露的分析物。然而，很少有研究调查胎粪与子宫内雄激素暴露之间的关系。在此，我们研究了睾酮和脱氢表雄酮（DHEA）与母体产前唾液睾酮、脐带血、胎粪和婴儿唾液睾酮之间的关系。本研究共纳入了 47 名无并发症的单胎妊娠妇女及其婴儿。参与者是从一家学术性产科诊所招募的。在妊娠 36 周时采集孕妇唾液。出生时采集脐带血和胎粪。在婴儿 1 周大和 4 周大时采集其唾液中的睾酮。多变量模型结果显示，胎粪中的睾酮与新生儿出生后 1 周（F = 5.62，p = 0.029）和 4 周（F = 4.28，p = 0.048）时的睾酮有关；未发现性别差异。这项研究表明，胎粪是评估内源性雄激素暴露的重要工具，应在未来的研究中用于调查胎儿的激素环境。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Developmental psychobiology 生物-发育生物学

CiteScore

4.20

自引率

18.20%

发文量

125

审稿时长

6-12 weeks

期刊介绍： Developmental Psychobiology is a peer-reviewed journal that publishes original research papers from the disciplines of psychology, biology, neuroscience, and medicine that contribute to an understanding of behavior development. Research that focuses on development in the embryo/fetus, neonate, juvenile, or adult animal and multidisciplinary research that relates behavioral development to anatomy, physiology, biochemistry, genetics, or evolution is appropriate. The journal represents a broad phylogenetic perspective on behavior development by publishing studies of invertebrates, fish, birds, humans, and other animals. The journal publishes experimental and descriptive studies whether carried out in the laboratory or field. The journal also publishes review articles and theoretical papers that make important conceptual contributions. Special dedicated issues of Developmental Psychobiology , consisting of invited papers on a topic of general interest, may be arranged with the Editor-in-Chief. Developmental Psychobiology also publishes Letters to the Editor, which discuss issues of general interest or material published in the journal. Letters discussing published material may correct errors, provide clarification, or offer a different point of view. Authors should consult the editors on the preparation of these contributions.