IF 2.6 4区心理学

Stress-The International Journal on the Biology of Stress Pub Date : 2025-12-01 Epub Date: 2025-04-12 DOI: 10.1080/10253890.2025.2489942

Jordan N Carroll, Brent Myers, Christopher E Vaaga

{"title":"Repeated presentation of visual threats drives innate fear habituation and is modulated by threat history and acute stress exposure.","authors":"Jordan N Carroll, Brent Myers, Christopher E Vaaga","doi":"10.1080/10253890.2025.2489942","DOIUrl":"https://doi.org/10.1080/10253890.2025.2489942","url":null,"abstract":"To survive predation, animals must be able to detect and appropriately respond to predator threats in their environment. Such defensive behaviors are thought to utilize hard-wired neural circuits for threat detection, sensorimotor integration, and execution of ethologically-relevant behaviors. Despite being hard-wired, defensive behaviors (i.e. fear responses) are not fixed, but rather show remarkable flexibility, suggesting that extrinsic factors such as threat history, environmental contexts, and physiological state may alter innate defensive behavioral responses. The goal of the present study was to examine how extrinsic and intrinsic factors influence innate defensive behaviors in response to visual threats. In the absence of a protective shelter, our results indicate that mice showed robust freezing behavior following both looming (proximal) and sweeping (distal) threats, with increased behavioral vigor in response to looming stimuli, which represent a higher threat imminence. Repeated presentation of looming or sweeping stimuli at short inter-trial intervals resulted in robust habituation of freezing, which was accelerated at longer inter-trial intervals, regardless of contextual cues. Finally, prior stress history such as acute foot shock further disrupted innate freezing habituation, resulting in a delayed habituation phenotype, consistent with a heightened fear state. Together, our results indicate that extrinsic factors such as threat history, environmental familiarity, and stressors have robust and diverse effects on defensive behaviors, highlighting the behavioral flexibility in how mice respond to predator threats.","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"28 1","pages":"2489942"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The silent pandemic of stress: impact on menstrual cycle and ovulation. 压力的无声流行：对月经周期和排卵的影响。

IF 2.6 4区心理学

Stress-The International Journal on the Biology of Stress Pub Date : 2025-12-01 Epub Date: 2025-01-25 DOI: 10.1080/10253890.2025.2457767

Mariam Saadedine, Sarah L Berga, Stephanie S Faubion, Chrisandra L Shufelt

{"title":"The silent pandemic of stress: impact on menstrual cycle and ovulation.","authors":"Mariam Saadedine, Sarah L Berga, Stephanie S Faubion, Chrisandra L Shufelt","doi":"10.1080/10253890.2025.2457767","DOIUrl":"10.1080/10253890.2025.2457767","url":null,"abstract":"In the current age of technological advancement, stress has emerged as a silent pandemic affecting individuals, especially young generations, globally. Factors such as increased competition, social pressures fueled by social media and smartphones, and a sense of diminished control in the face of modern challenges contribute to rising stress levels. In addition to the negative implications on mental well-being, stress affects physiological processes such as the menstrual cycle. Functional hypogonadotropic hypogonadism is a spectrum ranging ranging from regular menstrual cycles with short or insufficient luteal phases to irregular cycles, oligomenorrhea, anovulation, and complete amenorrhea, depending on how stress variably disrupts gonadotropic-releasing hormone (GnRH) drive. Functional hypothalamic amenorrhea (FHA), the most severe manifestation, is a complex global neuroendocrinopathy with several serious health consequences in addition to amenorrhea and infertility. Concomitant health consequences include bone loss, endothelial dysfunction, and cardiovascular risks. The collective health burden underscores the need for clinical awareness and comprehensive treatment strategies addressing behavioral and biopsychosocial stressors that lead to chronic hypothalamic-pituitary-adrenal (HPA) axis activation. Despite its prevalence and numerous adverse health consequences, research on this condition remains limited, revealing a significant gap in understanding and addressing this condition. Larger and long-term follow-up studies are important to accurately assess FHA prevalence, its health consequences, intervention efficacy, and recovery outcomes.","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"28 1","pages":"2457767"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11793426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparing 4th and 5th graders to learn algebra with worked examples and self-explanation prompts. 用实例和自我解释提示帮助四、五年级学生学习代数。

IF 2 2区心理学

Journal of Experimental Child Psychology Pub Date : 2025-12-01 Epub Date: 2025-08-08 DOI: 10.1016/j.jecp.2025.106348

Kelly M McGinn, Julie L Booth, Alexandra Huyghe

{"title":"Preparing 4th and 5th graders to learn algebra with worked examples and self-explanation prompts.","authors":"Kelly M McGinn, Julie L Booth, Alexandra Huyghe","doi":"10.1016/j.jecp.2025.106348","DOIUrl":"10.1016/j.jecp.2025.106348","url":null,"abstract":"This study examined the effects of the MathByExample intervention, which integrates worked examples and self-explanation prompts into math worksheets to address 4th and 5th graders' misconceptions. Researchers conducted a year-long, classroom-based experiment in 58 U.S. classrooms, randomly assigning classrooms to experimental or control conditions. The study explored the intervention's impact on algebra readiness and the moderating effects of prior knowledge and intervention dosage. Results showed no significant overall impact of the intervention on foundational algebra knowledge (FAK) or preparation for future learning (PFL). However, further analysis provided key insights. For FAK scores, greater self-explanation prompt attempts improved learning, but only when students engaged with a high number of worksheets. Students with higher prior knowledge experienced a negative effect of attempting more worksheets, suggesting they may not benefit from excessive practice. Self-explanation attempts had a stronger positive effect for students with higher prior knowledge. For PFL scores, self-explanation attempts significantly improved PFL scores, but only for students with at least average prior knowledge, with the strongest effects seen in those completing more worksheets. These findings suggest that educators may benefit from actively incorporating the study and explanation of worked examples into elementary math instruction. To maximize their impact, teachers should regularly integrate worked examples into their lessons. Encouraging students to engage with worked examples through self-explanation may mitigate common misconceptions and enhance students' readiness for more advanced algebra concepts.","PeriodicalId":48391,"journal":{"name":"Journal of Experimental Child Psychology","volume":"260 ","pages":"106348"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can exosomes link the cellular and endocrine stress response? A test using the brown anole lizard (Anolis sagrei) as a model. 外泌体能否连接细胞和内分泌应激反应？一项以棕蜥（Anolis sagrei）为模型的测试。

IF 2.6 4区心理学

Stress-The International Journal on the Biology of Stress Pub Date : 2025-12-01 Epub Date: 2025-05-29 DOI: 10.1080/10253890.2025.2509912

Nicole Rodriguez-Martinez, Anna Kaza, H Bobby Fokidis

{"title":"Can exosomes link the cellular and endocrine stress response? A test using the brown anole lizard (Anolis sagrei) as a model.","authors":"Nicole Rodriguez-Martinez, Anna Kaza, H Bobby Fokidis","doi":"10.1080/10253890.2025.2509912","DOIUrl":"https://doi.org/10.1080/10253890.2025.2509912","url":null,"abstract":"Exosomes are nanoscale extracellular vesicles critical for intercellular communication, but their role in vertebrate stress responses remains unclear. We investigated exosome involvement in stress responses using brown anole lizards (Anolis sagrei), hypothesizing that acute stress would increase plasma exosome concentrations and inhibiting exosome secretion would attenuate the stress response. Using mixed-sex adult brown anoles (total n = 54 pairs), we conducted three experiments: a timed stress series, an adrenocorticotropic hormone (ACTH) challenge, and an exosome synthesis inhibitor (GW4869) challenge. Exosome concentrations were quantified using Nanoparticle Tracking Analysis and acetylcholinesterase (AChE) activity, while corticosterone levels were measured via enzyme-linked immunoassay (ELISA). Acute handling stress increased both plasma corticosterone and exosome concentrations, with a moderate significant correlation. ACTH injection elevated corticosterone but did not affect exosome levels. Blocking exosome synthesis with GW4869 significantly reduced corticosterone secretion, suggesting exosomes may play an indirect or concurrent role in stress regulation. This research provides the first in vivo evidence of exosomes' involvement in endocrine stress responses, offering a novel perspective on cellular stress signaling and potentially revealing an evolutionarily conserved mechanism of intercellular communication during stress adaptation.","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"28 1","pages":"2509912"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of glucose homeostasis in burnout cases using an oral glucose tolerance test. 用口服葡萄糖耐量试验研究倦怠患者的葡萄糖稳态。

IF 2.6 4区心理学

Stress-The International Journal on the Biology of Stress Pub Date : 2025-12-01 Epub Date: 2024-12-17 DOI: 10.1080/10253890.2024.2438699

Anna-Karin Lennartsson, Ingibjörg H Jonsdottir, Per-Anders Jansson, Anna Sjörs Dahlman

{"title":"Study of glucose homeostasis in burnout cases using an oral glucose tolerance test.","authors":"Anna-Karin Lennartsson, Ingibjörg H Jonsdottir, Per-Anders Jansson, Anna Sjörs Dahlman","doi":"10.1080/10253890.2024.2438699","DOIUrl":"https://doi.org/10.1080/10253890.2024.2438699","url":null,"abstract":"Burnout is caused by long term psychosocial stress and has, besides the fatigue and mental health burden, been associated with increased risk of adverse physical health, such as for example type 2 diabetes. This study aims to investigate the glucose and insulin levels in individuals with stress related burnout, by assessing these metabolic markers in response to a standard oral glucose tolerance test (OGTT). 38 cases with burnout (13 men and 25 women) and 35 healthy controls (13 men and 22 women) in the age 24-55 were included in the study. The burnout group overall did not differ from healthy controls in glucose or insulin levels during the OGTT. However, the burnout cases who reported more severe burnout symptoms exhibited significantly higher levels of both glucose and insulin levels during the OGTT compared to burnout cases reporting lower severity of symptoms. Furthermore, the group of burnout cases who reported symptoms of depression exhibited higher insulin levels during OGTT compared to the burnout cases without depressive symptoms. The observed higher levels in the burnout cases with most severe symptoms indicate an increased diabetic risk in these patients and it may be of importance to follow glucose and insulin levels in individuals with more severe symptoms of burnout i.e. to perform an OGTT.","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"28 1","pages":"2438699"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of the menstrual cycle phases and time of day on markers of stress: salivary α-amylase and secretory immunoglobulin A. 月经周期阶段和时间对应激指标的影响：唾液α-淀粉酶和分泌免疫球蛋白A。

IF 2.6 4区心理学

Stress-The International Journal on the Biology of Stress Pub Date : 2025-12-01 Epub Date: 2025-01-05 DOI: 10.1080/10253890.2024.2449098

Josey K Walker, Courtney C Dillard, Drew E Gonzalez, Hunter S Waldman, Matthew J McAllister

{"title":"Impact of the menstrual cycle phases and time of day on markers of stress: salivary α-amylase and secretory immunoglobulin A.","authors":"Josey K Walker, Courtney C Dillard, Drew E Gonzalez, Hunter S Waldman, Matthew J McAllister","doi":"10.1080/10253890.2024.2449098","DOIUrl":"https://doi.org/10.1080/10253890.2024.2449098","url":null,"abstract":"Previous reports suggest that the menstrual cycle (MC) phases can impact cortisol concentrations. However, research is needed on whether the MC impacts other markers of stress and immune function. It has also been shown that some biomarkers are impacted by time of day, although differences between morning (AM) and afternoon (PM) biomarkers have not been studied over the course of the MC. This study assessed the effect of MC phases and time of day on salivary stress biomarkers [salivary α-amylase (sAA), secretory immunoglobulin A (SIgA)], progesterone, resting blood pressure and resting heart rate (RHR). A single-group repeated measure design was employed in which seventeen participants (n = 17) monitored their MC for two months while attending eight experimental sessions which included both AM and PM sessions during each predicted 1) menses, 2) follicular, 3) ovulatory and 4) luteal phases. Resting blood pressures, heart rates, body composition parameters (assessed via bioelectrical impedance analysis), sAA and SIgA concentrations were assessed. No time of day x MC phase interactions (p > 0.05) were noted for sAA or SIgA, resting blood pressure, heart rate, or body composition parameters. However, sAA and RHR were significantly higher in the PM, while SIgA was significantly higher in the AM. These data suggest that the MC phases do not impact sAA or SIgA, resting blood pressure, heart rates, or body composition parameters. However, time-of-day impacts RHR and concentrations of sAA and SIgA. These findings provide implications for female participants in research dealing with these biomarkers.","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"28 1","pages":"2449098"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular correlates of childhood adversity - a multi-omics perspective on stress regulation. 童年逆境的分子关联——应激调节的多组学视角。

IF 2.6 4区心理学

Stress-The International Journal on the Biology of Stress Pub Date : 2025-12-01 Epub Date: 2025-04-30 DOI: 10.1080/10253890.2025.2495918

Johannes C S Zang, Caroline May, Katrin Marcus, Robert Kumsta

{"title":"Molecular correlates of childhood adversity - a multi-omics perspective on stress regulation.","authors":"Johannes C S Zang, Caroline May, Katrin Marcus, Robert Kumsta","doi":"10.1080/10253890.2025.2495918","DOIUrl":"https://doi.org/10.1080/10253890.2025.2495918","url":null,"abstract":"The experience of adversity in childhood can have life-long consequences on health outcomes. In search of mediators of this relationship, alterations of bio-behavioral and cellular regulatory systems came into focus, including those dealing with basic gene regulatory processes. System biology oriented approaches have been proposed to gain a more comprehensive understanding of the complex multiple interrelations between and within layers of analysis. Here, we used co-expression based, supervised and unsupervised single and multi-omics systems approaches to investigate the association between childhood adversity and gene expression, protein expression and DNA methylation in CD14+ monocytes in the context of psychosocial stress exposure, in a sample of healthy adults with (n = 29) or without (n = 27) a history of childhood adversity. Childhood adversity explained some variance at the single analyte level and within gene and protein co-expression structures. A single-omics, post-stress gene expression model differentiated best between participants with a history of childhood adversity and control participants in supervised analyses. In unsupervised analyses, a multi-omics based model showed best performance but separated participants based on sex only. Multi-omics analyses are a promising concept but might yield different results based on the specific approach taken and the omics-datasets supplied. We found that stress associated gene-expression pattern were most strongly associated with childhood adversity, and integrating multiple cellular layers did not results in better discriminatory performance in our rather small sample. The capacity and yield of different omics-profiling methods might currently limit the full potential of integrative approaches.","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"28 1","pages":"2495918"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The TSST triggers self-reported stress and biological stress and frustrates basic psychological needs: general and specific buffering effects of physical activity and social support. TSST触发自我报告的压力和生物压力，挫败基本心理需求：体育活动和社会支持的一般和特定缓冲作用。

IF 2.6 4区心理学

Stress-The International Journal on the Biology of Stress Pub Date : 2025-12-01 Epub Date: 2025-05-19 DOI: 10.1080/10253890.2025.2503984

Julia Schüler, Simona Rindelhardt, Beate Ditzen

{"title":"The TSST triggers self-reported stress and biological stress and frustrates basic psychological needs: general and specific buffering effects of physical activity and social support.","authors":"Julia Schüler, Simona Rindelhardt, Beate Ditzen","doi":"10.1080/10253890.2025.2503984","DOIUrl":"https://doi.org/10.1080/10253890.2025.2503984","url":null,"abstract":"Situations characterized by uncontrollability and critical social evaluation frustrate basic psychological needs, as outlined in Self-Determination Theory (SDT). Uncontrollability and social evaluation are central elements of the Trier Social Stress Test (TSST), leading to the hypothesis that the TSST, in addition to increasing self-reported stress and cortisol responses, also frustrates the needs for autonomy, competence, and social relatedness. Participants (N = 195) reported elevated stress and reduced need satisfaction, and increased cortisol responses during the TSST. The roles of assessed physical activity and experimentally-induced social support were also examined. Indeed, in time-sensitive and specific manner, the TSST frustrated basic psychological needs. Social support however mitigated frustration of social relatedness. Physical activity buffered against self-reported stress, the frustration of competence and the cortisol response. Further research is recommended to explore more differentiated interventions that can counteract the negative effects of psychosocial stressors.","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"28 1","pages":"2503984"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adverse childhood experiences (ACEs) and repeated wheezing from 6 to 30 months of age: exploring the role of race and ethnicity. 不良童年经历（ace）和6至30个月大的反复喘息：探索种族和民族的作用。

IF 2.6 4区心理学

Stress-The International Journal on the Biology of Stress Pub Date : 2025-12-01 Epub Date: 2025-03-12 DOI: 10.1080/10253890.2025.2477530

Francheska M Merced-Nieves, Marina Schechter, Elena Colicino, Allison Frost, Rosalind J Wright

{"title":"Adverse childhood experiences (ACEs) and repeated wheezing from 6 to 30 months of age: exploring the role of race and ethnicity.","authors":"Francheska M Merced-Nieves, Marina Schechter, Elena Colicino, Allison Frost, Rosalind J Wright","doi":"10.1080/10253890.2025.2477530","DOIUrl":"10.1080/10253890.2025.2477530","url":null,"abstract":"Identifying children at risk for respiratory disorders involves understanding early risk factors. This study prospectively examines how specific types of early adversity influence childhood wheeze and how these vary by race and ethnicity. Analyses included N = 746 mother-infant dyads from an urban pregnancy cohort. Mothers completed the Lifetime Stressor Checklist-Revised (LSC-R), Edinburgh Postnatal Depression Scale (EPDS), Spielberger State-Trait Anxiety Inventory (STAI), Posttraumatic stress disorder Checklist-Civilian version (PCL-C), and Traumatic Events Screening Inventory (TESI) when infants were 6 months old to assess adverse childhood experiences (ACEs). Mothers reported child wheeze at 4-month intervals to index wheezing episodes from age 6-30 months. We first assessed independent associations between ACE measures and wheeze frequency using Poisson regression. We then used weighted quantile sum (WQS) regression to derive an ACEs mixture index to estimate joint associations with wheeze frequency in the overall sample and stratified by maternal race and ethnicity adjusting for child sex, maternal asthma and education. There was a 2.05 increase (95% CI = 1.21, 3.49) in wheeze frequency with each quintile increase of the ACEs index in Black/Black Hispanics; the TESI (72%) contributed most strongly to the mixture. In non-Black Hispanics, there was a 1.33 (95% CI = 1.05, 1.67) increase in wheeze frequency with each ACEs quintile increase with EPDS (76%) contributing most strongly. Findings support the need to move the ACEs paradigm beyond a simple cumulative score when examining effects on early respiratory disease risk. Results also highlight how the impact of early life ACEs varies by ethnoracial identity.","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"28 1","pages":"2477530"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12011106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stress exacerbates DNCB-induced atopic dermatitis in BALB/c mice: association with modulation of the gut microbiome. 应激加剧了dncb诱导的BALB/c小鼠的特应性皮炎：与肠道微生物组的调节有关

IF 2.6 4区心理学

Stress-The International Journal on the Biology of Stress Pub Date : 2025-12-01 Epub Date: 2025-07-07 DOI: 10.1080/10253890.2025.2525801

So Min Lee, Keun Hyang Eom, Jeeyoun Jung, Jun-Chul Kang, Jae-Sang Ryu, You Mee Ahn, Ji-Yeun Park

{"title":"Stress exacerbates DNCB-induced atopic dermatitis in BALB/c mice: association with modulation of the gut microbiome.","authors":"So Min Lee, Keun Hyang Eom, Jeeyoun Jung, Jun-Chul Kang, Jae-Sang Ryu, You Mee Ahn, Ji-Yeun Park","doi":"10.1080/10253890.2025.2525801","DOIUrl":"https://doi.org/10.1080/10253890.2025.2525801","url":null,"abstract":"Atopic dermatitis (AD) is a widely recognized chronic inflammatory skin disease influenced by dietary habits, stress, genetic factors, and environmental factors. This study aimed to explore the impact of stress on AD exacerbation, as well as the associated changes in the gut microbiota. We utilized a 2,4-dinitrochlorobenzene (DNCB)-induced AD mouse model subjected to chronic restraint stress (CRS). The animals were divided into four groups: normal, sham control (sham), AD, and AD+CRS. Scratching behavior was significantly increased in the AD+CRS group compared to the AD group on day 28, indicating that stress exacerbates pruritus in AD. Relative abundance analysis of the gut microbiota at the phylum level revealed an increased relative abundance of Bacteroidota in both the AD and AD+CRS groups. Principal coordinate analysis revealed distinct patterns between the AD and AD+CRS groups. The relative abundance of Heminiphilus was negatively correlated with immunoglobulin E (IgE) levels, while the relative abundance of Ruminococcus exhibited significant and negative correlations with both corticosterone and IgE levels. Alistipes, which is known to aggravate AD, was notably elevated in the AD+CRS group. These findings confirm that stress-related changes in the gut microbiota composition may contribute to the exacerbation of AD, highlighting the connection among stress, immune response, and microbiome dynamics in AD progression.","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"28 1","pages":"2525801"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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