IF 3.7 4区心理学

Stress-The International Journal on the Biology of Stress Pub Date : 2026-12-31 Epub Date: 2026-07-07 DOI: 10.1080/10253890.2026.2687780

Timo-Kolja Pförtner, Ibrahim Demirer, Julia Schwichtenberg, Laven Mavarani, Börge Schmidt

{"title":"Explaining variations in allostatic load in later life: a longitudinal cohort study of socioeconomic life course mechanisms in Germany.","authors":"Timo-Kolja Pförtner, Ibrahim Demirer, Julia Schwichtenberg, Laven Mavarani, Börge Schmidt","doi":"10.1080/10253890.2026.2687780","DOIUrl":"10.1080/10253890.2026.2687780","url":null,"abstract":"Different life course models explain variations in allostatic load (AL) as the accumulation, sensitive period, path, and social mobility models. This study investigates which life course models are most instrumental in explaining AL in later life. Three waves of the longitudinal German Heinz Nixdorf Recall cohort study were used considering 11,959 observations of 4,814 individuals aged 45-75 years at baseline. AL was derived from 13 biomarkers and socioeconomic status (SES) was measured by life course and current SES. Random-effects linear regression models were employed to test for the sensitive period and path models. An interaction effect between life course and current SES was considered to test for the accumulation and social mobility models. The path model was tested by mediation modeling using the g-formula approach. Both life course and current SES were significantly and negatively associated with AL across all models, with current SES showing stronger effect. A significant positive interaction between the two SES measures supported the accumulation and social mobility models. Mediation analysis confirmed the path model, showing that current SES significantly mediated a substantial portion (49.0-73.4%) of the life course SES effect on AL, while the remaining direct effect offers partial support for the sensitive period model. The results indicate that the biological embedding of socioeconomic disadvantage is driven by the simultaneous operation of multiple life course mechanisms. Strongest empirical evidence supports the path model, supplemented by partial evidence for the sensitive period model, and further nuanced by processes of accumulation and social mobility.","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"29 1","pages":"2687780"},"PeriodicalIF":3.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148400016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antidepressant-like effects of valproic acid in rodents go back to the 1980s: a comment to enrich the reviewed evidence by Goudarzi et al. (2026) "Valproic acid effects on stress-induced depression-like behavior in rodent models: a systematic review and meta-analysis". 丙戊酸对啮齿动物的抗抑郁作用可以追溯到20世纪80年代：这一评论丰富了Goudarzi等人（2026）的评论证据，“丙戊酸对啮齿动物模型中压力诱导的抑郁样行为的影响：系统回顾和荟萃分析”。

IF 3.7 4区心理学

Stress-The International Journal on the Biology of Stress Pub Date : 2026-12-31 Epub Date: 2026-07-30 DOI: 10.1080/10253890.2026.2709368

Alberto Fernández-Teruel

{"title":"Antidepressant-like effects of valproic acid in rodents go back to the 1980s: a comment to enrich the reviewed evidence by Goudarzi et al. (2026) \"Valproic acid effects on stress-induced depression-like behavior in rodent models: a systematic review and meta-analysis\".","authors":"Alberto Fernández-Teruel","doi":"10.1080/10253890.2026.2709368","DOIUrl":"10.1080/10253890.2026.2709368","url":null,"abstract":"In a recent review and meta-analysis, Goudarzi et al. (Stress, 2026 Dec 31; 29(1):2641561) show that valproic acid (VPA) exhibits antidepressant (AD)-like effects in several procedures involving the induction of depression-like symptoms by prior sub-chronic or chronic stress in laboratory rats or mice. In their review, the authors included reports of experimental studies (covering only from 2007 to 2024), using several validated depression-like behaviors, such as decreased sucrose preference, increased immobility in the forced swim test (FST), decreased activity in the open field test, and/or impaired novel object recognition memory. The meta-analysis of the 19 included studies showed that sub-chronic/chronic VPA treatment improves most of these depression-like symptoms. The present \"Comment\" article aims to highlight that the first demonstrations of VPA AD-like and passive coping-reducing effects date back to the 1980s. Our group was the first to demonstrate AD-like effects of sub-acute and chronic VPA treatments in the forced swim test in rats (in 1988). These effects were partially antagonized by pre-test injections of the GABA-A receptor complex antagonists bicuculline and picrotoxin, thus suggesting that VPA-induced passive coping reduction was at least partly mediated by enhancement of GABA-A neurotransmission. Shortly thereafter (1989), the AD-like effects of VPA were confirmed in the FST in mice. These reports from the late 1980s, showing positive effects of VPA on the FST in rats and mice, constitute relevant precedents that further strengthen the profile of AD-like effects of VPA reported by Goudarzi et al.","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"29 1","pages":"2709368"},"PeriodicalIF":3.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148621956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stress response physiology in the cardiac patient: from the laboratory to real life. 心脏病人的应激反应生理学：从实验室到现实生活。

IF 3.7 4区心理学

Stress-The International Journal on the Biology of Stress Pub Date : 2026-12-31 Epub Date: 2026-09-25 DOI: 10.1080/10253890.2026.2723352

Viola Vaccarino, Amit J Shah, Puja K Mehta, Brad Pearce, Paolo Raggi, J Douglas Bremner, Arshed Quyyumi

{"title":"Stress response physiology in the cardiac patient: from the laboratory to real life.","authors":"Viola Vaccarino, Amit J Shah, Puja K Mehta, Brad Pearce, Paolo Raggi, J Douglas Bremner, Arshed Quyyumi","doi":"10.1080/10253890.2026.2723352","DOIUrl":"https://doi.org/10.1080/10253890.2026.2723352","url":null,"abstract":"Recognition of a \"brain-heart axis\" has grown substantially, highlighting the contribution of psychological stress on cardiovascular physiology and the development and progression of cardiovascular disease (CVD). This connection appears particularly consequential for individuals with established CVD. Laboratory-based mental stress paradigms have been central to uncovering the mechanisms linking psychological stress with cardiovascular outcomes, implicating autonomic dysregulation and its downstream effects on immune function, vascular reactivity, and myocardial ischemia. Dynamic alterations in autonomic and molecular pathways during stress or negative emotional states may serve not only as critical determinants of cardiovascular risk but also as potential markers of heightened vulnerability. Certain patient groups-women, individuals with mental health conditions, and those facing adverse psychosocial exposures such as racial minorities-are especially susceptible to these stress-related effects. Recent advances extend these insights beyond controlled laboratory settings, demonstrating that ambulatory assessments of autonomic physiology are related to momentary psychological states in everyday life. This updated review synthesizes emerging knowledge on mind-body interactions in CVD and outlines promising avenues for future intervention. Collectively, the evidence underscores the importance of an integrative framework that considers psychological and biological processes jointly to fully understand the pathophysiology and outcome of CVD.","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"29 1","pages":"2723352"},"PeriodicalIF":3.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149065702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A U-shaped relationship between perceived chronic stress and the approach motivation: evidence from resting-state EEG. 感知慢性应激与接近动机呈u型关系：来自静息状态脑电图的证据。

IF 3.7 4区心理学

Stress-The International Journal on the Biology of Stress Pub Date : 2026-12-31 Epub Date: 2026-09-05 DOI: 10.1080/10253890.2026.2720484

Yu Xi, Wei Yi, Wangxiao Chen, Jianhui Wu

{"title":"A U-shaped relationship between perceived chronic stress and the approach motivation: evidence from resting-state EEG.","authors":"Yu Xi, Wei Yi, Wangxiao Chen, Jianhui Wu","doi":"10.1080/10253890.2026.2720484","DOIUrl":"https://doi.org/10.1080/10253890.2026.2720484","url":null,"abstract":"Chronic stress facilitates the development and progression of multiple psychiatric disorders, including depression and addiction. The dysregulation of approach motivation has been proposed as a mechanism of chronic stress, but it is unclear how chronic stress is related to approach motivation. The current study sought to elucidate the relationship between chronic stress and resting-state electroencephalographic (EEG) measures of approach motivation. Sixty undergraduate students filled out the Perceived Stress Scale (PSS) and were recorded with resting-state EEG. Hierarchical regression analyses revealed significant quadratic (U-shaped) associations between mean-centered PSS scores and all three EEG measures: alpha frontal asymmetry (AFA) (β = 0.32, 95% CI [0.0001, 0.0018], p = 0.032), delta power (β = 0.33, 95% CI [0.0003, 0.0036], p = 0.021), and theta power (β = 0.31, 95% CI [0.0002, 0.0035], p = 0.030). All quadratic effects remained statistically significant after false discovery rate (FDR; Benjamini-Hochberg) correction (all adjusted ps < 0.05). These findings suggest that there is a nonlinear relationship between chronic stress and approach motivation, i.e. at both low and high chronic stress levels, resting-state activation of approach motivation is enhanced, whereas at moderate chronic stress levels, approach motivation is reduced, probably reflecting more efficient allocation and conservation of brain resources. More importantly, our findings demonstrate the necessity of examining the baseline neural state in addition to the task-evoked responses when assessing stress-related changes of approach motivation, thereby providing novel insights into the mechanisms of stress adaptation and their implications for psychological health.","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"29 1","pages":"2720484"},"PeriodicalIF":3.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148898417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between pubertal timing and diurnal cortisol activity in middle adolescence. 青春期中期青春期时间与皮质醇日活动的关系。

IF 3.7 4区心理学

Stress-The International Journal on the Biology of Stress Pub Date : 2026-12-31 Epub Date: 2026-08-15 DOI: 10.1080/10253890.2026.2718133

Ellie Roberts, Eirini Flouri

引用次数: 0

Harsh parenting and rs11621961 at the SERPINA6/1 locus: gene-environment interaction effects on hair cortisol in a Brazilian population-based longitudinal study. 严厉的父母教养和SERPINA6/1位点的rs11621961：巴西人群纵向研究中基因-环境相互作用对头发皮质醇的影响

IF 3.7 4区心理学

Stress-The International Journal on the Biology of Stress Pub Date : 2026-12-31 Epub Date: 2026-01-05 DOI: 10.1080/10253890.2025.2611613

Laísa Camerini, Joseph Murray, Alicia Matijasevich, Mariana Otero Xavier, Carolina Bonilla, Júlia Pasqualini Genro, Andrea Gonzalez, Luís Augusto Rohde, Laura Moreira Goularte, Iná S Santos, Isabel O Oliveira, Sarah L Halligan, Luciana Tovo-Rodrigues

{"title":"Harsh parenting and rs11621961 at the SERPINA6/1 locus: gene-environment interaction effects on hair cortisol in a Brazilian population-based longitudinal study.","authors":"Laísa Camerini, Joseph Murray, Alicia Matijasevich, Mariana Otero Xavier, Carolina Bonilla, Júlia Pasqualini Genro, Andrea Gonzalez, Luís Augusto Rohde, Laura Moreira Goularte, Iná S Santos, Isabel O Oliveira, Sarah L Halligan, Luciana Tovo-Rodrigues","doi":"10.1080/10253890.2025.2611613","DOIUrl":"10.1080/10253890.2025.2611613","url":null,"abstract":"Hair cortisol concentration (HCC) reflects long-term hypothalamic-pituitary-adrenal (HPA) axis activity and is a biomarker of chronic stress. Although HCC has been linked to mental health, less is known about how genetic susceptibility and early adversity jointly influence cortisol regulation, particularly in low- and middle-income countries (LMICs). This study examined whether harsh parenting predicts adolescent HCC and whether this association is moderated by genetic variation. Data were drawn from 1,823 participants in the 2004 Pelotas (Brazil) Birth Cohort, followed at ages 6, 11, and 15. Genetic data were obtained using the Illumina Global Screening Array v2, and HCC was measured at age 15 using ELISA. Harsh parenting was assessed using the Conflict Tactics Scales: Parent-Child Version, and cumulative exposure was analyzed using linear regression models. Gene-by-environment interaction analyses tested whether rs11621961 moderated the association between harsh parenting and HCC. Greater cumulative exposure to harsh parenting, particularly overall harsh parenting and corporal punishment, was associated with higher HCC at age 15. Evidence of G × E interaction indicated stronger associations among individuals carrying more copies of the T allele, suggesting a gene-dosage effect. These findings highlight how genetic susceptibility may amplify the physiological consequences of early-life stress in LMIC settings.","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"29 1","pages":"2611613"},"PeriodicalIF":3.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145906881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a novel analysis method for evaluating PTSD-like behavior in mice based on DSM-V criteria. 基于DSM-V标准评估小鼠ptsd样行为的新分析方法的发展。

IF 3.7 4区心理学

Stress-The International Journal on the Biology of Stress Pub Date : 2026-12-31 Epub Date: 2026-01-10 DOI: 10.1080/10253890.2025.2612332

Heather Holman, Kaylee Eggert, Ying Xiong, Paul J Nietert, Sara J Sidles, Ryan R Kelly, Amanda C LaRue, Patrick J Mulholland, Jennifer A Rinker, Jeffrey A Jones

{"title":"Development of a novel analysis method for evaluating PTSD-like behavior in mice based on DSM-V criteria.","authors":"Heather Holman, Kaylee Eggert, Ying Xiong, Paul J Nietert, Sara J Sidles, Ryan R Kelly, Amanda C LaRue, Patrick J Mulholland, Jennifer A Rinker, Jeffrey A Jones","doi":"10.1080/10253890.2025.2612332","DOIUrl":"10.1080/10253890.2025.2612332","url":null,"abstract":"Posttraumatic stress disorder (PTSD) occurs after exposure to a traumatic event, leading to debilitating symptoms, including avoidance, hypervigilance, and functional impairment. There is a paucity of effective therapies to treat PTSD, partially due to the difficulty in identifying consistent underlying mechanisms. Using a modified single prolonged stress (mSPS) paradigm combined with single housing to induce both acute fear conditioning and chronic stress in mice, we developed a novel analysis method to robustly define a PTSD-like phenotype based on the criteria from the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-V). Following mSPS exposure, C57BL/6NHsd mice underwent behavioral testing to examine each of the criteria of PTSD according to the DSM-V. Specific parameters with the largest effect sizes between mSPS and non-mSPS mice were chosen. Absolute z-scores were generated for each behavioral parameter, and mSPS mice whose z-scores were outside the 85th confidence interval for at least one parameter for each of the eight criteria were defined as susceptible; the remainder of the exposed mice were considered resilient. Finally, resilient mice were evaluated for anhedonia and hyperlocomotive behaviors. The results demonstrated that a PTSD-like phenotype can be robustly defined in mice based on all 8 DSM-V criteria. Importantly, 29.76% of mSPS mice were classified as susceptible, which is similar to the incidence observed in humans exposed to trauma. This novel behavioral analysis method may assist in better defining a PTSD-like phenotype, identifying a more robust population, which may help facilitate the discovery of the underlying mechanism(s) of PTSD and its association with other comorbidities.","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"29 1","pages":"2612332"},"PeriodicalIF":3.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13244265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145946694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between high perceived stress, inflammatory proteins, and BDNF: a cross-sectional study of young adult females in Shanghai, China. 高感知应激、炎症蛋白和BDNF之间的关系：中国上海年轻成年女性的横断面研究

IF 3.7 4区心理学

Stress-The International Journal on the Biology of Stress Pub Date : 2026-12-31 Epub Date: 2026-08-27 DOI: 10.1080/10253890.2026.2723346

Ping Gao, Hong Zhang, Xue Xiao, Wencai Jiang, Yimei Tan, Xuelan Gu

{"title":"Associations between high perceived stress, inflammatory proteins, and BDNF: a cross-sectional study of young adult females in Shanghai, China.","authors":"Ping Gao, Hong Zhang, Xue Xiao, Wencai Jiang, Yimei Tan, Xuelan Gu","doi":"10.1080/10253890.2026.2723346","DOIUrl":"10.1080/10253890.2026.2723346","url":null,"abstract":"Psychological stress accelerates aging, increasing morbidity and mortality risks, though the mechanisms behind this relationship are still under investigation. This cross-sectional study explored the link between perceived stress and blood protein profiles by recruiting healthy female subjects (aged 18-35) stratified into high (HS) and low (LS) perceived stress groups according to self-reported subjective questionnaires in Shanghai, China. The HS group displayed a higher tendency of neuroticism along with depression, anxiety, and emotional volatility. The exploratory proteomic analysis of blood samples was performed, evaluating 92 inflammation/immune related proteins using the Olink high-throughput platform. Concurrently, targeted analysis of pre-specified stress-related neurological biomarkers including brain-derived neurotrophic factor (BDNF) and oxytocin were performed using Enzyme-linked immunosorbent assay (ELISA). The results demonstrated that the HS group displayed elevated levels of eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1, log2FC = 0.565) and sirtuin 2 (SIRT2, log2FC = 0.383). Age-segregated analysis (early young adult (EYA), 18-25 years old; middle young adult (MYA), 25-30 years old; late young adult (LYA), 30-35 years old) revealed that BDNF was decreased in the LYA group and demonstrated a moderate negative correlation with 4E-BP1 and SIRT2. Cytokines interleukin-8 (IL-8) and IL-10 were also significantly elevated in the LYA group. These findings indicated that Chinese, young women with HS exhibit distinct inflammatory profiles and reduced BDNF levels, suggesting that chronic stress may be associated with increased inflammation and compromised neuronal plasticity, highlighting the need for future longitudinal studies to clarify the long-term impact of stress on mental wellbeing.","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"29 1","pages":"2723346"},"PeriodicalIF":3.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148834453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal prepregnancy body mass index predicts allostatic load in adult offspring: findings from an Australian birth cohort. 孕妇孕前体重指数预测成年后代的适应负荷：来自澳大利亚出生队列的研究结果。

IF 3.7 4区心理学

Stress-The International Journal on the Biology of Stress Pub Date : 2026-12-31 Epub Date: 2026-05-08 DOI: 10.1080/10253890.2026.2669543

Beena Suvarna, Oyelola Adegboye, Sabine Finlay, Abdullah Ai Mamun, Robert-Paul Juster, Brett McDermott, Zoltan Sarnyai

{"title":"Maternal prepregnancy body mass index predicts allostatic load in adult offspring: findings from an Australian birth cohort.","authors":"Beena Suvarna, Oyelola Adegboye, Sabine Finlay, Abdullah Ai Mamun, Robert-Paul Juster, Brett McDermott, Zoltan Sarnyai","doi":"10.1080/10253890.2026.2669543","DOIUrl":"10.1080/10253890.2026.2669543","url":null,"abstract":"Maternal pre- or early-pregnancy obesity is a risk factor for adverse health outcomes not only in the mother but also for the child later in life. It can lead to sustained and inappropriate stimulation of regulatory circuits, eventually resulting in multisystem dysregulation, termed allostatic load (AL). We hypothesized that maternal prepregnancy weight status, as measured by body mass index (BMI), exerts long-lasting effects on offspring, potentially resulting in elevated AL. Using data from the Mater University of Queensland Study of Pregnancy (MUSP), a longitudinal birth cohort (>8500 pregnant women), we investigate the association between maternal prepregnancy BMI and AL in adult offspring at age 30. Analyses were conducted in a subsample of 923 offspring with complete biomarker data, from whom an AL index capturing 17 multisystem physiological dysregulations was constructed. Structural equation modelling (SEM) was used to examine pathways linking maternal prepregnancy BMI to offspring AL index (ALI). Lower maternal socioeconomic status (SES) was associated with higher maternal BMI. Maternal prepregnancy BMI was positively associated with offspring AL index (β = 0.17, standard error (SE) = 0.01, p < 0.001), whereas mental health risk factors did not mediate this relationship. These findings suggest that maternal metabolic status at pre- and early-pregnancy exerts a long-lasting effect on offspring physiology, independent of maternal SES and mental health. Our findings underscore the practical importance of maternal weight management before pregnancy to support optimal offspring development.","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"29 1","pages":"2669543"},"PeriodicalIF":3.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early life stress and glucocorticoid signaling in zebrafish embryos. 斑马鱼胚胎的早期生活压力和糖皮质激素信号。

IF 3.7 4区心理学

Stress-The International Journal on the Biology of Stress Pub Date : 2026-12-31 Epub Date: 2026-08-17 DOI: 10.1080/10253890.2026.2718136

Michael Burman, Willard Swift, Tyler McGoldrick, Gabriel Stoehr

{"title":"Early life stress and glucocorticoid signaling in zebrafish embryos.","authors":"Michael Burman, Willard Swift, Tyler McGoldrick, Gabriel Stoehr","doi":"10.1080/10253890.2026.2718136","DOIUrl":"10.1080/10253890.2026.2718136","url":null,"abstract":"Early life stress produces lasting changes in both neurological and endocrine development that alter later life behavior, stress response, and mental health. Zebrafish have been demonstrated to be useful organisms for studying the effects of early life stress because of their ease of manipulation during the postnatal period, availability of genetic tools, lack of confounding parental care, and well-established behavioral repertoire. The current studies establish a model of early life stress using intermittent light and vibration exposure that creates reductions in baseline locomotion and light/dark transition-induced movement at 4 days post-fertilization. The effects of early life stress on locomotion were mimicked by genetic disruption of the glucocorticoid receptor through a grs357 point mutation and at least partially reversed by pharmacological blockade of cortisol synthesis. In contrast, exogenous hydrocortisone failed to recapitulate the effects of early life stress, but instead increased locomotor behavior, which is consistent with evidence that corticosteroids can alter the rate of locomotor development.","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"29 1","pages":"2718136"},"PeriodicalIF":3.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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