心理学最新文献

{"title":"Possible effects of radiofrequency electromagnetic radiation on contextual fear conditioning, hippocampal perivascular space, apoptosis and adrenal gland microarchitecture in rats.","authors":"Sareesh Naduvil Narayanan, Raju Suresh Kumar, Naveen Kumar, Pavithra Prabhakar, Satheesha Badagabettu Nayak, Perumunda Gopalakrishna Bhat","doi":"10.1016/j.bbr.2025.115424","DOIUrl":"10.1016/j.bbr.2025.115424","url":null,"abstract":"<p><p>Whilst the world sees the tremendous growth of mobile phone technology, radiofrequency electromagnetic radiation (RF-EMR) induced possible health effects have emerged as a topic of recent day debate. The current study is designed to test the hypothesis that chronic 900 MHz radiation exposure would potentially dysregulate the stress response system (HPA axis) in vivo, via, its non-thermal mechanisms, leading to alterations in the microarchitecture of the adrenal gland, vulnerable brain regions such as the hippocampus which may results in altered behaviours in rats. Male albino Wistar rats aged four weeks, weighing 50-60 g were subjected to 900 MHz radiation from a mobile phone for four weeks at a rate of one hour per day. On the 29th day, animals from the control, sham exposed and RF-EMR exposed groups were tested for contextual fear conditioning. They were later euthanized to study hippocampal and adrenal gland cytoarchitecture. Bright and dark compartment transitions in the avoidance box were considerably elevated in the RF-EMR exposed group and they exhibited a significant decrease in the latency to enter the dark compartment during the contextual fear conditioning test. Apoptosis was apparent in the CA3 region and perivascular space was significantly increased in the hippocampus of the radiation-exposed group. In addition to lymphocytic infiltrates, congested sinusoids, apoptotic-like changes were evident in the zona fasciculata of the adrenal gland. However, the cytoarchitecture of the adrenal medulla was comparable in all three groups. Chronic RF-EMR exposure caused changes in contextual fear conditioning, enlargement of hippocampal perivascular space, apparent CA3 apoptosis, and apoptotic-like changes in the zona fasciculata of the adrenal gland in rats.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"115424"},"PeriodicalIF":2.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142943573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baseline gray matter volume associates with working memory performance after prefrontal transcranial direct current stimulation.","authors":"Oscar Martin-Garcia, Pedro Henrique Rodrigues da Silva, Stefanie De Smet, Sara De Witte, Andre R Brunoni, Marie-Anne Vanderhasselt, Lais B Razza","doi":"10.1016/j.bbr.2025.115416","DOIUrl":"10.1016/j.bbr.2025.115416","url":null,"abstract":"<p><p>Working memory is crucial for daily life and is often impaired in neuropsychiatric conditions. Attempts to enhance it using transcranial direct current stimulation (tDCS) have shown mixed results, possibly due to large inter-individual variability. This study assessed whether baseline regional brain volume was associated with working memory performance following tDCS. Healthy participants were randomly assigned to three bilateral tDCS protocols (sham, 1.5 mA, and 3 mA) over the dorsolateral prefrontal cortex (dlPFC) (anode-left, cathode-right) for 20 minutes, in a within-subjects design with a 2-week interval, followed by emotional and non-emotional 3-back tasks. Baseline volumetric data were used to extract gray matter volumes of defined regions of interest; the dlPFC, the medial PFC (mPFC), and the posterior cingulate cortex (PCC) bilaterally. Data from thirty-nine participants (69.2 % female, mean age: 24.56 years) across 112 tDCS sessions were analyzed. Findings revealed no significant association between working memory performance post sham-tDCS and gray matter volume. However, larger baseline cortical volumes across all regions were associated with slower reaction times and lower accuracy for the non-emotional task at 1.5 mA, whereas non-significant results were observed at 3 mA. For the emotional task, only a significant association for reaction time after 3 mA and left dlPFC and right PCC were found. Findings highlight not only the association between individual baseline gray matter, but also the impact of methodological choices, such as current intensity and outcome, on the effect of tDCS. Future research should aim to further explore individual variability and methodological factors to deepen our understanding of the mechanisms underlying tDCS.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"481 ","pages":"115416"},"PeriodicalIF":2.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The basic theory and application of the mirror neuron system in dysphagia after stroke.","authors":"Le Wang, Yi Li, Ruyao Liu, Heping Li, Liugen Wang, Xi Zeng","doi":"10.1016/j.bbr.2025.115430","DOIUrl":"10.1016/j.bbr.2025.115430","url":null,"abstract":"<p><p>The discovery of the brain's mirror neuron system enables researchers to gain a deeper understanding of social cognitive activities from the level of neural mechanisms. Mirror neurons are situated in bilateral brain regions, overlapping with the swallowing neural network, and there are complex network pathways connecting the two. Repeatedly inducing the activation of mirror neurons in stroke patients can enhance the brain's ability to relearn its original swallowing function, and then restore the swallowing neural network. With the deepening of related studies, rehabilitation therapies based on the mirror neuron system have been discussed and explored by numerous scholars and applied to the rehabilitation of dysphagia after stroke. In this paper, we review the basic theory of mirror neuron system, its mechanism, its relevance to the swallowing neural network, and the clinical application and research progress of related rehabilitation therapies in stroke dysphagia, with a view to triggering relevant researchers to comprehend and innovate the rehabilitation of dysphagia after stroke.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"481 ","pages":"115430"},"PeriodicalIF":2.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep brain stimulation of the medial forebrain bundle promotes the extinction of active avoidance and is associated with mossy fibber sprouting in the hippocampus.","authors":"Carles Tapias-Espinosa, Soleil García-Brito, Laia Vila-Solés, Gemma Huguet, Elisabet Kádár, Laura Aldavert-Vera, Pilar Segura-Torres, Gemma Carreras-Badosa","doi":"10.1016/j.bbr.2024.115411","DOIUrl":"10.1016/j.bbr.2024.115411","url":null,"abstract":"<p><strong>Background: </strong>Post-traumatic stress disorder (PTSD) causes intrusive symptoms and avoidance behaviours due to dysregulation in various brain regions, including the hippocampus. Deep brain stimulation (DBS) shows promise for refractory PTSD cases. In rodents, DBS improves fear extinction and reduces anxiety-like behaviours, but its effects on active-avoidance extinction remain unexplored. Medial forebrain bundle intracranial self-stimulation (MFB-ICSS) enhances two-way active avoidance (TWAA) conditioning by activating brain regions involved in reinforcement, learning, and memory, including the hippocampus.</p><p><strong>Methods: </strong>This study investigates whether reinforcing DBS in the MFB enhances the extinction of conditioned active avoidance responses and examines its effects on hippocampal mossy fibber sprouting using Timm staining. We administered MFB-ICSS treatment following two 50-trial extinction sessions and assessed short-term (24 hours) and long-term (28 days) extinction in a TWAA task in rats.</p><p><strong>Results: </strong>MFB-ICSS enhances short-term extinction and accelerates long-term reacquisition of extinction in a spontaneous recovery test. MFB-ICSS also promotes mossy fibber sprouting in the CA2 and CA3 regions of the hippocampus, with CA3 staining positively correlated with the level of extinction.</p><p><strong>Conclusions: </strong>These findings suggest that MFB stimulation may enhance extinction and promote neural plasticity mechanisms, including mossy fibber sprouting. However, it does not fully prevent spontaneous recovery, highlighting the need for further optimization of treatment parameters. These results are relevant for PTSD as they suggest a potential enhancement in therapy for extinguishing avoidance responses in patients.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"115411"},"PeriodicalIF":2.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-dependent effects of rat maternal immune activation on motor function in offspring of poly I:C treated rats.","authors":"K Jack Scott, David K Bilkey","doi":"10.1016/j.bbr.2025.115431","DOIUrl":"10.1016/j.bbr.2025.115431","url":null,"abstract":"<p><p>A majority of people with schizophrenia will experience motor symptoms such as impairments to coordination, balance and motor sequencing. These neurological soft signs are associated with negative social and functional outcomes, and poor disease prognosis. They occur prior to medication exposure, suggesting they are an intrinsic feature of schizophrenia. Despite the need to better understand this dysfunction, relatively few studies have provided a detailed focus on motor capability in animal models of schizophrenia. Here we investigate motor coordination in a rat maternal immune activation (MIA) model of schizophrenia risk. The female and male offspring of Polyinosinic:polycytidylic acid (Poly I:C), and vehicle-treated, pregnant dams were tested in a horizontal ladder rung task using regular and irregular rung configurations. We extracted information about limb positions from video, and measured faults and gait coordination in the task. We found that adult male MIA rats were more likely to slip from the ladder rungs than control animals, and they were more likely to have multiple limbs slip simultaneously. MIA rats also exhibited more variability in stride length, a result that correlated with slips and mirrored disease-related changes in human gait. In contrast, female MIA rats displayed minimal alterations in motor performance. Our findings show that the ladder task uncovers sex-dependent effects on motor coordination in MIA rats and highlights the potential usefulness of the MIA model for investigating motor dysfunction in an animal model of schizophrenia risk.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"481 ","pages":"115431"},"PeriodicalIF":2.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of sensorimotor responses in larval zebrafish: A comparison between wild-type and GCaMP6s transgenic line.","authors":"Margaux Caperaa, Mathilde Roland-Caverivière, Chelsea Herdman, Nesrine Imloul, Sandrine Poulin, Mado Lemieux, Paul De Koninck, Gabriel D Bossé","doi":"10.1016/j.bbr.2024.115412","DOIUrl":"10.1016/j.bbr.2024.115412","url":null,"abstract":"<p><p>During early development, zebrafish larvae exhibit stereotypical behaviors, which rapidly become more complex. Thus, generating mutant transgenic lines that maintain transparency throughout their larval stage and that can be used to record brain activity has offered strategic opportunities to investigate the underlying neural correlates of behavior establishment. However, few studies have documented the sensorimotor profile of these lines during larval development. Here, we set up a behavioral characterization using diverse stimuli (light and vibration) throughout larval development to compare the responses of a transgenic strain expressing a pan-neuronal calcium indicator (GCaMP6s) with that of a wild-type strain. Interestingly, we report a drastic switch in behavioral responses to light transitions at 11 days post-fertilization (dpf) and to vibration stimuli at 14 dpf in both lines. These data highlight a specific time window representing an increase in behavioral complexity. Meanwhile, we found some differences in the maturation of sensorimotor responses between GCaMP6s and wild-type strains. Although some of these differences are minor, they highlight the need for careful attention when using mutant/transgenic lines for behavioral studies. Overall, our results support using GCaMP6s strain in investigating the neural mechanisms underlying the developmental maturation of sensorimotor responses.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"115412"},"PeriodicalIF":2.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of neurofeedback training on behavior and brain functional networks in children with autism spectrum disorder.","authors":"Jiannan Kang, Shuaikang Lv, Yuqi Li, Pengfei Hao, Xiaoli Li, Chunxia Gao","doi":"10.1016/j.bbr.2025.115425","DOIUrl":"10.1016/j.bbr.2025.115425","url":null,"abstract":"<p><p>Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with an unclear pathogenesis to date. Neurofeedback (NFB) had shown therapeutic effects in patients with ASD. In this study,we analyzed the brain functional networks of children with ASD and investigated the impact of NFB targeting the beta rhythm training on these networks. The Autism Behavior Checklist (ABC) and Social Response Scale (SRS) were employed to evaluate the effects of NFB training on the behavioral abilities of children with ASD. We compared the differences in static and dynamic brain functional networks between ASD and Typically Developing (TD) children, also explored the changes in these networks in ASD children after 20 sessions of NFB training. The Weighted Phase Lag Index (wPLI) was used to construct static functional networks, and the Fuzzy Entropy (FuzzyEn) algorithm was further employed to measure the complexity of static functional connectivity and construct dynamic functional networks. This allowed the analysis of functional connectivity and fluctuations in the static functional networks of ASD and TD children, as well as the time variability of the dynamic functional networks. Additionally, the study explored the changes in brain functional networks and behavioral scales before and after NFB training. Results from behavioral scales indicated significant improvements in cognitive, communication, language, and social scores in ASD children following NFB intervention. EEG analysis revealed that static functional connectivity was lower, connectivity variability was higher, and temporal variability was greater in ASD children compared to TD children. Following NFB training, increased functional connectivity, reduced connectivity variability in the Delta frequency band, and decreased temporal variability were observed in ASD children. The results revealed abnormalities in both static and dynamic functional networks in children with ASD, with NFB training showed potential to modulate these networks. While our results showed that NFB training can assist participants in regulating connectivity and temporal variability in specific brain regions, robust evidence for its effectiveness in alleviating core symptoms of ASD remained limited.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"115425"},"PeriodicalIF":2.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142943574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebrolysin treatment improved short-term memory deficits while simultaneously increasing hippocampal spine density in hypertensive female rats.","authors":"Ivette Espinoza, Ma de Jesús Gómez-Villalobos, Leonardo Aguilar-Hernández, Gonzalo Flores, Julio César Morales-Medina","doi":"10.1016/j.bbr.2025.115436","DOIUrl":"10.1016/j.bbr.2025.115436","url":null,"abstract":"<p><p>Hypertension, if untreated, can disrupt the blood-brain-barrier (BBB) and reduce cerebral flow in the central nervous system (CNS) inducing hippocampal atrophy, potentially leading to cognitive deficits and vascular dementia. Spontaneous hypertensive rats (SHR) demonstrated neuroplastic alterations in the hippocampus, hyperlocomotion and memory deficits in males. Cerebrolysin (CBL), a neuropeptide preparation, induces synaptic and neuronal plasticity in various populations of neurons and repairs the integrity of the BBB. This research aims to investigate the behavioral outcomes in locomotion and recognition memory in the Novel Object Recognition Test (NORT) and assess the neuroreparative effect of CBL on the cytoarchitecture of neurons and the spine density in pyramidal neurons of the prefrontal cortex (PFC), the entorhinal cortex (EC) and the CA1 region of the dorsal hippocampus, as well as spheroidal neurons of the dentate gyrus (DG). Our findings indicate that SHR exhibited elevated diastolic and systolic pressures, and increased locomotion. Importantly, CBL treatment improved recognition memory in SHR strain. Hypertension led to reduced arborization in the EC, CA1, and DG regions. Moreover, CBL treatment increased arborization in both normotensive and hypertensive rats in the CA1, and DG regions of hippocampus and EC and selectively increased spine density in the hippocampus of hypertensive rats. These findings suggest that CBL neurotrophic treatment enhances recognition memory and promotes dendritic growth or spine density, depending on the neurochemical environment within the brain.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"481 ","pages":"115436"},"PeriodicalIF":2.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropharmacological potential of Mimosa tenuiflora in adult zebrafish: An integrated approach to GABAergic and serotonergic neuromodulation.","authors":"José Ismael Feitosa de Araújo, Gabriela Alves do Nascimento, Antônio Eufrásio Vieira-Neto, Francisco Ernani Alves Magalhães, Adriana Rolim Campos","doi":"10.1016/j.bbr.2025.115415","DOIUrl":"10.1016/j.bbr.2025.115415","url":null,"abstract":"<p><p>Mimosa tenuiflora (\"jurema-preta\") is traditionally used in folk medicine for various diseases. The study investigated the neuropharmacological potential of Mimosa tenuiflora bark fraction (FATEM) in adult zebrafish. This included the acute toxicity (LC50) of FATEM (0.01; 0.05; 0.1; 0.5; 1.0 and 5.0 mg/mL; i.p.) and the effects on behavioral tests, such as open field, light & dark and zebrafish tail immobilization test (ZTI). The anxiolytic response induced by alcohol withdrawal and the seizure induced by pentylenetetrazole were also tested. The possible mechanisms of anxiolytic and antidepressant actions of FATEM were evaluated through the administration of specific antagonists (Flumazenil, Cyproheptadine, Pizotifen or Granisetron). Furthermore, the study investigated the ADME profile and molecular docking simulations of the major FATEM compound, Benzyloxyamine, with GABAergic and serotonergic receptors. FATEM did not present acute toxicity and caused a reduction in locomotor activity (p < 0.0001 vs. Control) similar (p< 0.0001) to Diazepam, indicating a sedative/anxiolytic effect. The anxiolytic activity in the light & dark test was similar to Diazepam (p < 0.0001), prevented by GABA and serotonergic antagonists. FATEM also prevented anxious behaviors induced by alcohol withdrawal and exhibited an antidepressant effect in the ZTI (p < 0.0001 vs. Control) similar (p < 0.0001) to the effect of Fluoxetine, which was reversed by serotonergic antagonists. In silico evaluations indicated favorable pharmacokinetic properties and affinity of FATEM with GABAergic and serotonergic receptors. The study reveals that FATEM has adequate physicochemical characteristics to act on the CNS with specific affinity for GABA_A and serotonergic receptors, indicating its potential as a treatment for anxiety and depression.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"481 ","pages":"115415"},"PeriodicalIF":2.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The gain-of-function variant in the NLRP3 gene predicts the effectiveness of brief psychotherapy but not the risk of major depression.","authors":"Fabiana Barreiros Ferreira, Fernanda Neutzling Kaufmann, Clarissa Ribeiro Bastos, Janaína Xavier, Stephanie Aniszewski, Mariane Lopez Molina, Diogo Rizzato Lara, Karen Jansen, Ricardo Azevedo da Silva, Luciano Dias de Mattos Souza, Manuella Pinto Kaster, Gabriele Ghisleni","doi":"10.1016/j.bbr.2024.115413","DOIUrl":"10.1016/j.bbr.2024.115413","url":null,"abstract":"<p><p>Major depressive disorder (MDD) is a highly prevalent psychiatric condition whose pathophysiology has been linked to neuroinflammatory processes involving the NLRP3 inflammasome. To address this point, the study investigated the association of the NLRP3 rs10754558 polymorphism with MDD diagnosis in a young adults population based study and the effectiveness of brief psychotherapies in a randomized clinical trial. A cross-sectional, population-based study was conducted with 1100 individuals aged 18-35 years, including 615 controls and 485 patients with MDD. Diagnosis was determined using the Mini International Neuropsychiatric Interview (M.I.N.I.) based on DSM-IV criteria. Our clinical trial included 227 participants with MDD aged 18-60 years from a randomized clinical trial evaluating the effectiveness of two brief psychotherapies for MDD. Depressive and anxiety symptoms were assessed at baseline, post-treatment (16-18 weeks), and 6-month follow-up using the Beck Depression Inventory-II (BDI-II) and the Beck Anxiety Inventory (BAI). Statistical analyses included logistic regression and generalized estimating equation (GEE) model adjusted for demographic and clinical variables. The results showed no significant association between rs10754558 genotypes and MDD diagnosis. However, when evaluating the efficacy of brief psychotherapies, the GG genotype was associated with poorer treatment outcomes for both depressive and anxiety symptoms compared to the GC/CC genotypes (p < 0.05). Longitudinal analysis revealed significant differences over time, with GG individuals demonstrating less symptom improvement (BDI-II: baseline 36.61 to follow-up 21.75; BAI: baseline 26.32 to follow-up 19.55) compared to GC/CC genotypes (BDI-II: baseline 32.05 to follow-up 20.29; BAI: baseline 22.05 to follow-up 17.96). These findings suggest that the GG genotype, previously characterized as a gain-of-function variant, may contribute to genetic heterogeneity influencing psychotherapy outcomes. This highlights the potential for genetic markers, such as rs10754558, to inform personalized psychiatric treatments and improve therapeutic strategies.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"115413"},"PeriodicalIF":2.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}