IF 2.6 4区心理学

Stress-The International Journal on the Biology of Stress Pub Date : 2025-12-01 Epub Date: 2025-01-05 DOI: 10.1080/10253890.2024.2449098

Josey K Walker, Courtney C Dillard, Drew E Gonzalez, Hunter S Waldman, Matthew J McAllister

{"title":"Impact of the menstrual cycle phases and time of day on markers of stress: salivary α-amylase and secretory immunoglobulin A.","authors":"Josey K Walker, Courtney C Dillard, Drew E Gonzalez, Hunter S Waldman, Matthew J McAllister","doi":"10.1080/10253890.2024.2449098","DOIUrl":"https://doi.org/10.1080/10253890.2024.2449098","url":null,"abstract":"Previous reports suggest that the menstrual cycle (MC) phases can impact cortisol concentrations. However, research is needed on whether the MC impacts other markers of stress and immune function. It has also been shown that some biomarkers are impacted by time of day, although differences between morning (AM) and afternoon (PM) biomarkers have not been studied over the course of the MC. This study assessed the effect of MC phases and time of day on salivary stress biomarkers [salivary α-amylase (sAA), secretory immunoglobulin A (SIgA)], progesterone, resting blood pressure and resting heart rate (RHR). A single-group repeated measure design was employed in which seventeen participants (n = 17) monitored their MC for two months while attending eight experimental sessions which included both AM and PM sessions during each predicted 1) menses, 2) follicular, 3) ovulatory and 4) luteal phases. Resting blood pressures, heart rates, body composition parameters (assessed via bioelectrical impedance analysis), sAA and SIgA concentrations were assessed. No time of day x MC phase interactions (p > 0.05) were noted for sAA or SIgA, resting blood pressure, heart rate, or body composition parameters. However, sAA and RHR were significantly higher in the PM, while SIgA was significantly higher in the AM. These data suggest that the MC phases do not impact sAA or SIgA, resting blood pressure, heart rates, or body composition parameters. However, time-of-day impacts RHR and concentrations of sAA and SIgA. These findings provide implications for female participants in research dealing with these biomarkers.","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"28 1","pages":"2449098"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular correlates of childhood adversity - a multi-omics perspective on stress regulation. 童年逆境的分子关联——应激调节的多组学视角。

IF 2.6 4区心理学

Stress-The International Journal on the Biology of Stress Pub Date : 2025-12-01 Epub Date: 2025-04-30 DOI: 10.1080/10253890.2025.2495918

Johannes C S Zang, Caroline May, Katrin Marcus, Robert Kumsta

{"title":"Molecular correlates of childhood adversity - a multi-omics perspective on stress regulation.","authors":"Johannes C S Zang, Caroline May, Katrin Marcus, Robert Kumsta","doi":"10.1080/10253890.2025.2495918","DOIUrl":"https://doi.org/10.1080/10253890.2025.2495918","url":null,"abstract":"The experience of adversity in childhood can have life-long consequences on health outcomes. In search of mediators of this relationship, alterations of bio-behavioral and cellular regulatory systems came into focus, including those dealing with basic gene regulatory processes. System biology oriented approaches have been proposed to gain a more comprehensive understanding of the complex multiple interrelations between and within layers of analysis. Here, we used co-expression based, supervised and unsupervised single and multi-omics systems approaches to investigate the association between childhood adversity and gene expression, protein expression and DNA methylation in CD14+ monocytes in the context of psychosocial stress exposure, in a sample of healthy adults with (n = 29) or without (n = 27) a history of childhood adversity. Childhood adversity explained some variance at the single analyte level and within gene and protein co-expression structures. A single-omics, post-stress gene expression model differentiated best between participants with a history of childhood adversity and control participants in supervised analyses. In unsupervised analyses, a multi-omics based model showed best performance but separated participants based on sex only. Multi-omics analyses are a promising concept but might yield different results based on the specific approach taken and the omics-datasets supplied. We found that stress associated gene-expression pattern were most strongly associated with childhood adversity, and integrating multiple cellular layers did not results in better discriminatory performance in our rather small sample. The capacity and yield of different omics-profiling methods might currently limit the full potential of integrative approaches.","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"28 1","pages":"2495918"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adverse childhood experiences (ACEs) and repeated wheezing from 6 to 30 months of age: exploring the role of race and ethnicity. 不良童年经历（ace）和6至30个月大的反复喘息：探索种族和民族的作用。

IF 2.6 4区心理学

Stress-The International Journal on the Biology of Stress Pub Date : 2025-12-01 Epub Date: 2025-03-12 DOI: 10.1080/10253890.2025.2477530

Francheska M Merced-Nieves, Marina Schechter, Elena Colicino, Allison Frost, Rosalind J Wright

{"title":"Adverse childhood experiences (ACEs) and repeated wheezing from 6 to 30 months of age: exploring the role of race and ethnicity.","authors":"Francheska M Merced-Nieves, Marina Schechter, Elena Colicino, Allison Frost, Rosalind J Wright","doi":"10.1080/10253890.2025.2477530","DOIUrl":"10.1080/10253890.2025.2477530","url":null,"abstract":"Identifying children at risk for respiratory disorders involves understanding early risk factors. This study prospectively examines how specific types of early adversity influence childhood wheeze and how these vary by race and ethnicity. Analyses included N = 746 mother-infant dyads from an urban pregnancy cohort. Mothers completed the Lifetime Stressor Checklist-Revised (LSC-R), Edinburgh Postnatal Depression Scale (EPDS), Spielberger State-Trait Anxiety Inventory (STAI), Posttraumatic stress disorder Checklist-Civilian version (PCL-C), and Traumatic Events Screening Inventory (TESI) when infants were 6 months old to assess adverse childhood experiences (ACEs). Mothers reported child wheeze at 4-month intervals to index wheezing episodes from age 6-30 months. We first assessed independent associations between ACE measures and wheeze frequency using Poisson regression. We then used weighted quantile sum (WQS) regression to derive an ACEs mixture index to estimate joint associations with wheeze frequency in the overall sample and stratified by maternal race and ethnicity adjusting for child sex, maternal asthma and education. There was a 2.05 increase (95% CI = 1.21, 3.49) in wheeze frequency with each quintile increase of the ACEs index in Black/Black Hispanics; the TESI (72%) contributed most strongly to the mixture. In non-Black Hispanics, there was a 1.33 (95% CI = 1.05, 1.67) increase in wheeze frequency with each ACEs quintile increase with EPDS (76%) contributing most strongly. Findings support the need to move the ACEs paradigm beyond a simple cumulative score when examining effects on early respiratory disease risk. Results also highlight how the impact of early life ACEs varies by ethnoracial identity.","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"28 1","pages":"2477530"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12011106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The TSST triggers self-reported stress and biological stress and frustrates basic psychological needs: general and specific buffering effects of physical activity and social support. TSST触发自我报告的压力和生物压力，挫败基本心理需求：体育活动和社会支持的一般和特定缓冲作用。

IF 2.6 4区心理学

Stress-The International Journal on the Biology of Stress Pub Date : 2025-12-01 Epub Date: 2025-05-19 DOI: 10.1080/10253890.2025.2503984

Julia Schüler, Simona Rindelhardt, Beate Ditzen

{"title":"The TSST triggers self-reported stress and biological stress and frustrates basic psychological needs: general and specific buffering effects of physical activity and social support.","authors":"Julia Schüler, Simona Rindelhardt, Beate Ditzen","doi":"10.1080/10253890.2025.2503984","DOIUrl":"https://doi.org/10.1080/10253890.2025.2503984","url":null,"abstract":"Situations characterized by uncontrollability and critical social evaluation frustrate basic psychological needs, as outlined in Self-Determination Theory (SDT). Uncontrollability and social evaluation are central elements of the Trier Social Stress Test (TSST), leading to the hypothesis that the TSST, in addition to increasing self-reported stress and cortisol responses, also frustrates the needs for autonomy, competence, and social relatedness. Participants (N = 195) reported elevated stress and reduced need satisfaction, and increased cortisol responses during the TSST. The roles of assessed physical activity and experimentally-induced social support were also examined. Indeed, in time-sensitive and specific manner, the TSST frustrated basic psychological needs. Social support however mitigated frustration of social relatedness. Physical activity buffered against self-reported stress, the frustration of competence and the cortisol response. Further research is recommended to explore more differentiated interventions that can counteract the negative effects of psychosocial stressors.","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"28 1","pages":"2503984"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemogenetic inhibition of corticotropin releasing hormone neurons in the paraventricular nucleus attenuates traumatic stress-induced deficit of NREM sleep, but not REM sleep in mice. 室旁核促肾上腺皮质激素释放激素神经元的化学发生抑制可减弱创伤应激诱导的小鼠非快速眼动睡眠缺陷，而非快速眼动睡眠缺陷。

IF 2.6 4区心理学

Stress-The International Journal on the Biology of Stress Pub Date : 2025-12-01 Epub Date: 2025-02-16 DOI: 10.1080/10253890.2025.2465393

Andrey Kostin, Natalia Suntsova, Sunil Kumar, Irma Gvilia

{"title":"Chemogenetic inhibition of corticotropin releasing hormone neurons in the paraventricular nucleus attenuates traumatic stress-induced deficit of NREM sleep, but not REM sleep in mice.","authors":"Andrey Kostin, Natalia Suntsova, Sunil Kumar, Irma Gvilia","doi":"10.1080/10253890.2025.2465393","DOIUrl":"10.1080/10253890.2025.2465393","url":null,"abstract":"Present study was aimed to elucidate the role of corticotropin releasing hormone (CRH) neurons located in the paraventricular nucleus of the hypothalamus (PVN) in the mechanisms of stress-induced insomnia. Experiments were done in the rodent model of traumatic stress, mice exposure to the predator (rat) odor. Sleep changes associated with this model of stress were first assessed in adult male C57BL/6J wild-type mice (n = 12). The effect of chemogenetic silencing of CRH neurons within the PVN on traumatic stress-induced insomnia was examined in adult male CRH-ires-Cre mice using designer receptors exclusively activated by designer drugs (DREADD) technology. Animals received bilateral injections of inhibitory DREADD vector AAV-hSyn-DIO-hM4Di-mCherry (n = 10) or control AAV-hSyn-DIO-mCherry virus (n = 10) into the PVN during surgery. The DREADD was activated by intraperitoneal injection of clozapine-N-oxide (CNO) prior to the induction of traumatic stress. The exposure of mice to rat odor induced strong long-lasting suppression of both non-rapid eye movement (NREM) and rapid eye movement (REM) sleep stages in both experiments. Selective suppression of CRH neurons within the PVN alleviated acute insomnia by significantly increasing the time spent in NREM sleep but it did not counteract the stress-induced deficit in REM sleep. These findings suggest a specific role for CRH-secreting neurons within the PVN in the suppression of NREM sleep during acute insomnia caused by predator odor stress, whereas REM sleep suppression is controlled by a different mechanism.","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"28 1","pages":"2465393"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex differences in the murine HPA axis after acute and repeated restraint stress. 急性和反复约束应激后小鼠下丘脑轴的性别差异。

IF 2.6 4区心理学

Stress-The International Journal on the Biology of Stress Pub Date : 2025-12-01 Epub Date: 2024-12-30 DOI: 10.1080/10253890.2024.2447079

Isabella Flor Nalepa, Vibeke Nielsen, Tanja Esther Wolf, Chadi Touma, Morten Grupe, Ayodeji A Asuni, Cecilia Ratner

{"title":"Sex differences in the murine HPA axis after acute and repeated restraint stress.","authors":"Isabella Flor Nalepa, Vibeke Nielsen, Tanja Esther Wolf, Chadi Touma, Morten Grupe, Ayodeji A Asuni, Cecilia Ratner","doi":"10.1080/10253890.2024.2447079","DOIUrl":"10.1080/10253890.2024.2447079","url":null,"abstract":"Chronic stress and stress-related mental illnesses such as major depressive disorder (MDD) constitute some of the leading causes of disability worldwide with a higher prevalence in women compared to men. However, preclinical research into stress and MDD is heavily biased toward using male animals only. Aberrant activity of the hypothalamic-pituitary-adrenal (HPA) axis has been linked to the development of MDD and several animal models of MDD have been established based on HPA axis dysregulation. In the present study, we compared stress biomarkers and behavior of male and female mice after acute and chronic restraint stress to investigate potential effects of sex differences in the stress response. Further, the validity of the interrupted repeated restraint stress (IRRS) model as an animal model for the HPA axis disturbances seen in MDD was assessed. After acute stress, female mice showed increased corticosterone secretion and changes in molecular markers suggesting increased HPA axis feedback sensitivity. Acute stress-induced signs of anxiety-like behavior were observed in male mice only suggesting that female mice may be more resilient to the anxiogenic effects of acute stress. Males and females responded similarly to IRRS with no sustained perturbations in HPA axis biomarkers. The IRRS model did not adequately translate to the changes reported in MDD with HPA axis overactivity and more severe perturbation models are likely needed. However, in alignment with previous studies, these data support that there are important sex differences in the HPA axis and that these may contribute to the etiology of stress-related psychiatric disorders.","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"28 1","pages":"2447079"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic stress resulting from stressful life events and its role in the onset of primary Sjögren's syndrome: a comparative analysis using the modified Holmes-Rahe stress scale. 压力生活事件引起的慢性压力及其在原发性Sjögren综合征发病中的作用：使用改良Holmes-Rahe压力量表的比较分析

IF 2.6 4区心理学

Stress-The International Journal on the Biology of Stress Pub Date : 2025-12-01 Epub Date: 2025-01-10 DOI: 10.1080/10253890.2024.2447868

Marta Jaskólska, Iga Kościńska-Shukla, Dawid Jaskólski, Alessandro Viti, Marcin Ziętkiewicz, Michał Chmielewski

{"title":"Chronic stress resulting from stressful life events and its role in the onset of primary Sjögren's syndrome: a comparative analysis using the modified Holmes-Rahe stress scale.","authors":"Marta Jaskólska, Iga Kościńska-Shukla, Dawid Jaskólski, Alessandro Viti, Marcin Ziętkiewicz, Michał Chmielewski","doi":"10.1080/10253890.2024.2447868","DOIUrl":"10.1080/10253890.2024.2447868","url":null,"abstract":"Recent years brought considerable attention to the connection between chronic stress and the development of autoimmune diseases. However, little is still known about the impact of prolonged stress reactions on the onset and course of primary Sjögren Syndrome (pSS). This study aimed to seek for associations between chronic stress, resulting from stressful life events, and pSS. In the study, 50 patients with diagnosed pSS, as well as 50 control patients with osteoarthritis underwent an assessment. Modified Holmes-Rahe (H-R) stress scale was used in order to evaluate the impact of stressful events within 12 months prior to the diagnosis. Patients with pSS had a significantly higher total score on H-R stress scale within one-year preceding the disease diagnosis (152 ± 66.3 vs 50 ± 54.6; p <math><mrow><mo><</mo></mrow></math> 0.001). Additionally, the pSS patients more commonly than the controls reported a subjectively perceived correlation between stressful events and the occurrence of disease symptoms (50% vs 12%; p <math><mrow><mo><</mo></mrow></math> 0.001). Moreover, the H-R score at the time of the assessment correlated with the disease activity. The results support the view that pSS belongs to the group of diseases which pathogenesis is closely related to stressful life events. The novelty of this work lies in focus on both the correlation of stress on the onset of autoimmune disease as well as the activity of previously diagnosed disorder. Our data contributes to finding evidence-based medicine (EBM) arguments to what has until recently been merely a thematic observation-the harmfulness of negative stress on individual's health status.","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"28 1","pages":"2447868"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corticosterone rapidly modulates dorsomedial hypothalamus serotonin and behavior in an estrogen- and progesterone-dependent manner in adult female rats: potential role of organic cation transporter 3 (OCT3). 皮质酮以雌激素和孕激素依赖的方式快速调节成年雌性大鼠下丘脑背内侧5 -羟色胺和行为：有机阳离子转运体3 （OCT3）的潜在作用。

IF 2.6 4区心理学

Stress-The International Journal on the Biology of Stress Pub Date : 2025-12-01 Epub Date: 2025-02-03 DOI: 10.1080/10253890.2025.2457765

Jamie L Scholl, Joshua T Rogers, Na Feng, Gina L Forster, Michael J Watt, Jazmine D W Yaeger, Michael W Buchanan, Christopher A Lowry, Kenneth J Renner

{"title":"Corticosterone rapidly modulates dorsomedial hypothalamus serotonin and behavior in an estrogen- and progesterone-dependent manner in adult female rats: potential role of organic cation transporter 3 (OCT3).","authors":"Jamie L Scholl, Joshua T Rogers, Na Feng, Gina L Forster, Michael J Watt, Jazmine D W Yaeger, Michael W Buchanan, Christopher A Lowry, Kenneth J Renner","doi":"10.1080/10253890.2025.2457765","DOIUrl":"10.1080/10253890.2025.2457765","url":null,"abstract":"Previous studies have shown that corticosterone rapidly alters extracellular serotonin (5-hydroxytryptamine; 5-HT) concentrations in the dorsomedial hypothalamus (DMH) of adult male rats, suggesting a role for corticosterone actions in the DMH in regulation of physiological and behavioral responses. Whether or not corticosterone also rapidly alters extracellular serotonin concentrations in the DMH of female rats, and the dependence of this effect on ovarian hormones, is not known. To determine the effects of 17β-estradiol (E2), progesterone (P), and corticosterone on extracellular concentrations of serotonin in the DMH, corticosterone and/or P were delivered into the DMH of ovariectomized rats via reverse microdialysis in E2-primed rats. Combined, but not separate, delivery of corticosterone and P into the DMH rapidly and transiently increased extracellular 5-HT concentrations, a result that was dependent upon circulating E2. This effect of corticosterone on DMH 5-HT was replicated by local perfusion of the organic cation transporter 3 (OCT3) competitive inhibitor normetanephrine. Intra-DMH infusions of either corticosterone or normetanephrine also reversibly suppressed lordosis responses in E2 + P-primed females. These results suggest that ovarian hormones in combination with corticosterone modulate OCT3-mediated 5-HT clearance in the DMH, potentially representing an adaptive mechanism that allows sexually receptive females to respond rapidly to acute stressors.","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"28 1","pages":"2457765"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11801257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electroacupuncture improves sleep deprivation-induced cognitive impairment by suppressing hippocampal inflammatory response in mice. 电针通过抑制小鼠海马炎症反应改善睡眠剥夺引起的认知障碍。

IF 2.6 4区心理学

Stress-The International Journal on the Biology of Stress Pub Date : 2025-12-01 Epub Date: 2025-05-21 DOI: 10.1080/10253890.2025.2502742

Guoyan Li, Jingbo Liu, Kejing Zhang

{"title":"Electroacupuncture improves sleep deprivation-induced cognitive impairment by suppressing hippocampal inflammatory response in mice.","authors":"Guoyan Li, Jingbo Liu, Kejing Zhang","doi":"10.1080/10253890.2025.2502742","DOIUrl":"https://doi.org/10.1080/10253890.2025.2502742","url":null,"abstract":"Sleep deprivation (SD) is known to induce neurocognitive dysfunction, with hippocampal inflammation emerging as a critical mediator. Electroacupuncture has shown efficacy in modulating inflammation in neurological disorders, but its potential in mitigating SD-induced cognitive impairment remains underexplored. Using a murine model, we investigated the effects of electroacupuncture on hippocampal inflammation and cognitive function following SD treatment. BALB/c mice underwent sleep disruption using a multiple-platform apparatus and were subsequently treated with electroacupuncture. Cognitive function was assessed using the Morris Water Maze and Y-maze tests. Electroacupuncture treatment significantly ameliorated SD-induced cognitive impairment, as evidenced by improved performance in spatial memory tasks. Additionally, electroacupuncture attenuated hippocampal inflammation, characterized by reduced levels of pro-inflammatory cytokines (IL-1β, MCP-1 and TNF-α) and increased expression of the anti-inflammatory cytokine IL-10. Mechanistically, electroacupuncture suppressed microglial activation and inhibited the TLR4/NF-κB signaling pathway within the hippocampus. Electroacupuncture has therapeutic potential in mitigating SD-induced cognitive dysfunction by modulating hippocampal inflammation, which offers a promising non-pharmacological approach for preserving cognitive function in sleep-deprived individuals.","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"28 1","pages":"2502742"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronicles of Involuntary Career Changes: A Qualitative Longitudinal Analysis. 非自愿职业变化编年史：一个定性的纵向分析。

IF 2.8 2区心理学

Journal of Career Assessment Pub Date : 2025-08-01 Epub Date: 2024-10-01 DOI: 10.1177/10690727241289126

Caroline Éliane Brazier, Jonas Masdonati, Michaël Parmentier

{"title":"Chronicles of Involuntary Career Changes: A Qualitative Longitudinal Analysis.","authors":"Caroline Éliane Brazier, Jonas Masdonati, Michaël Parmentier","doi":"10.1177/10690727241289126","DOIUrl":"10.1177/10690727241289126","url":null,"abstract":"Although extensive research on career transitions exists, little is known about the challenges and processes of involuntary career change. Building on Savickas's theoretical framework of objective and subjective careers, we investigated the subjective experiences of involuntary career changes while apprehending their objective unfolding. Following a longitudinal qualitative design, we conducted two waves of semistructured interviews with 18 participants who had been forced to change careers due to health issues, migration, or saturated labor market in Switzerland. A four-step temporal thematic analysis covering case description, case comparison, case processes analysis, and processes comparison highlighted a spectrum of career change processes. At one end, individuals experienced synchronous progressions and regained meaning and control over their career combined with a rather linear status sequence. Conversely, some individuals underwent asynchronous developments consisting of either modest objective steps that instigated meaningful subjective experiences or status stagnation, leading to a loss of control and meaning. These findings underscore the variety of involuntary career change processes and unveil synchronicity as a key temporal element in involuntary career change processes. Implications for research and practice are discussed.","PeriodicalId":47978,"journal":{"name":"Journal of Career Assessment","volume":"33 3","pages":"592-613"},"PeriodicalIF":2.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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