心理学最新文献

{"title":"Stress-enhanced fear learning can be reduced with unconditional stimulus deflation with constraints.","authors":"Jaden B Brooks, Payton K Robinson, Sean Warner, Priya Halder, Sydney Trask","doi":"10.1016/j.bbr.2025.115438","DOIUrl":"10.1016/j.bbr.2025.115438","url":null,"abstract":"<p><p>Exposure to extreme stress can negatively impact behavior and lead to prolonged fear sensitization. These processes can be studied in the lab using stress-enhanced fear learning (SEFL), where prior exposure to inescapable stress exacerbates later contextual fear conditioning. A common method to reduce conditional fear is through extinction, where a conditional stimulus once paired with an unconditional (US; e.g., a footshock) is presented alone. Previous research shows that extinction learning may not be as effective at reducing fear behavior in rodents previously exposed to stress, mirroring similar extinction impairments observed in aged rodents. Weak-shock exposure (termed US deflation) following conditioning with a strong shock has been proposed to be an alternative to extinction where presentations of weaker versions of the US would work to modify the original fear memory rather than create a new memory as in extinction and thus more precisely target the original context fear memory. While effective under normal conditions, it has yet to be studied how effective US deflation is at reducing stress-enhanced context fear. Here we aimed to test if US deflation could reduce fear in a SEFL paradigm and identify any constraints of this effect. Following 15 inescapable footshocks or matched chamber exposure, male and female Long Evans rats received 1 context-shock pairing or 5 context-shock pairings in a novel context. The next day, they were given either 10 weak footshocks (US deflation) or extinction before behavioral testing. Following training with 1 context-shock pairing, both US deflation and extinction functioned similarly in reducing freezing behavior of stressed rodents. However, following 5 context-shock pairings, only the unstressed rodents displayed a significant decrease in fear behavior, suggesting that prior stress coupled with more robust conditioning can limit the efficacy of US deflation in reducing fear behavior. Finally, we replicated the SEFL effect in aged rodents and found that they showed a significant decrease in stress-enhanced fear learning following US deflation, whereas our previous research showed impairments of traditional extinction in aged rodents. Together, these results suggest that US deflation can reduce SEFL in both adult and aged rodents following a single context-shock pairing, with additional pairings rendering this procedure ineffective at mitigating the effects of prior stress.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"481 ","pages":"115438"},"PeriodicalIF":2.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treating anxiety comorbidity: Lessons from exposure generalization studies.","authors":"Armin Zlomuzica, Iris Kodzaga, Kayleigh Piovesan, Annalisa Lipp","doi":"10.1016/j.bbr.2024.115409","DOIUrl":"10.1016/j.bbr.2024.115409","url":null,"abstract":"<p><p>Comorbidity is a characteristic hallmark of anxiety disorders. Presence of comorbid anxiety and depression is challenging to the diagnosis and treatment. Conventional and transdiagnostic treatment options for anxiety disorders strongly depend on the use of exposure. Recent compelling evidence suggests that the beneficial effects of exposure therapy are transferable across different fear- and anxiety provoking situations and might even affect depressive symptomatology. We provide an overview of findings on existing studies on generalization of exposure effects to untreated stimuli and depression. Potential mechanisms which contribute to generalization of beneficial exposure therapy effects, such as extinction generalization, mastery-related increases in self-efficacy and underlying neural changes are presented and discussed. Understanding and promoting mechanisms related to exposure therapy efficacy and generalization can expedite and enhance the development of more effective transdiagnostic therapy approaches for comorbid anxiety disorders.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"115409"},"PeriodicalIF":2.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in sensorimotor integration, cervical sensorimotor control, and cognitive-motor dual tasking costs in chronic non-specific neck pain patients with high vs. low catastrophizing tendencies compared to healthy controls.","authors":"Ibrahim M Moustafa, Amal Ahbouch, Shima Abdollah Mohammad Zadeh, Tamer Shousha, Paul A Oakley, Deed Harrison","doi":"10.1016/j.bbr.2025.115434","DOIUrl":"10.1016/j.bbr.2025.115434","url":null,"abstract":"<p><p>Chronic non-specific neck pain (CNSNP) is a common condition and its relationship to the pain catastrophizing construct in terms of sensorimotor functions and dual task performance is not fully understood. We aimed to investigate the differences in sensorimotor integration, cervical sensorimotor control, and cognitive-motor dual tasking abilities between CNSNP patients (> 3 months) with high versus low catastrophizing tendencies and healthy controls. Ninety participants were recruited, 30 asymptomatic controls, and 60 patients with CNSNP; 30 scoring high (> 75th percentile) and 30 scoring low (< 25th percentile) on the pain catastrophizing scale (PCS). The variables of sensorimotor integration (frontal N30 amplitude), cervical sensorimotor control (head repositioning accuracy (HRA) - left and right), and cognitive-motor dual tasking (percentage of gait speed time increase with a cognitive load) were assessed and compared across groups. In general, performance of sensorimotor integration, cervical sensorimotor control, and cognitive-motor dual tasking abilities was incrementally better comparing the high to low catastrophizing groups, and the low catastrophizing group to the controls. Correlation coefficients between PCS and HRA (left and right) was strong (r = .8, p < 0.001), between PCS and dual tasking cost was moderate (r = .7, p < 0.001), and between PCS and frontal N30 amplitude was moderate (r = .57, p < 0.001). In conclusion, we found that higher pain catastrophizing was associated with poorer sensorimotor integration, cervical sensorimotor control, and cognitive-motor dual tasking in CNSNP patients highlighting the importance of both assessing and treating catastrophizing in the treatment of CNSNP. PERSPECTIVE: This study highlights the significant impact of pain catastrophizing on sensorimotor integration, cervical sensorimotor control, and cognitive-motor dual tasking in CNSNP patients. High catastrophizers are particularly vulnerable to these impairments, suggesting the need for comprehensive treatment approaches that address both psychological as well as physical components.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"481 ","pages":"115434"},"PeriodicalIF":2.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcranial magneto-acoustic stimulation enhances motor function and modulates cortical excitability of motor cortex in a Parkinson's disease mouse model.","authors":"Shuai Zhang, Qingzhao Wang, Yihao Xu, Haochen Zhang, Jinrui Mi, Xiaochao Lu, Ruiyang Fan, Jiangwei Lv, Guizhi Xu","doi":"10.1016/j.bbr.2024.115364","DOIUrl":"10.1016/j.bbr.2024.115364","url":null,"abstract":"<p><p>Parkinson's disease (PD) is a neurodegenerative disorder characterized primarily by motor dysfunction. Transcranial magneto-acoustic stimulation (TMAS), an emerging non-invasive brain neuromodulation technology, is increasingly being applied in the treatment of brain diseases. However, the effects of TMAS on PD are unknown, which is not well studied. Here, we utilized TMAS on PD model mice induced by MPTP to investigate the underlying mechanism of therapy. Our study found that TMAS improved the behavioral performance of PD model mice, enhancing the motor function and motivation for movement. Besides, it inhibited the increased beta oscillations in the motor cortex, while also reducing gamma oscillations. Moreover, the abnormally exaggerated beta-broad gamma phase amplitude coupling (PAC) was decreased after TMAS, and there was a significant negative correlation between PAC and both distance traveled and mean speed during the open filed test. Additionally, the ongoing stimulation could provide neuroprotection, implying that TMAS could ameliorate the loss of dopaminergic neurons, with no damage observed in the brain tissue of mice. Our findings suggest that TMAS could provide a non-invasive tool for the treatment of Parkinson's disease and beta-broad gamma phase amplitude coupling could be employed as a biomarker for PD.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"115364"},"PeriodicalIF":2.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fractionating impulsivity and reward-related phenotypes in adolescent mice.","authors":"Ruth Albert-Lyons, Stephanie S Desrochers, Catherine Fengler, Katherine M Nautiyal","doi":"10.1016/j.bbr.2024.115396","DOIUrl":"10.1016/j.bbr.2024.115396","url":null,"abstract":"<p><p>Adolescence is a developmental period characterized by changes in the brain and behavior, including heightened reward seeking, increased impulsivity, and elevated risk-taking behavior. It is also a sensitive period for the development of a number of behavioral and psychiatric disorders associated with pathological phenotypes of reward processing and impulsivity. Landmark human studies are charting the development of impulsivity and other reward-related phenotypes to identify the facets and timecourse of the adolescent phenotype. Collecting similar data from mice is important to enable molecular, cellular, and circuit-level interrogation of adolescent maturation of reward, motivation, and impulsive behavior. These complex phenotypes have traditionally been difficult to assay in adolescent mice. Here, using a combination of approaches including homecage testing, we tested a number of facets of reward seeking, impulsivity, motivation, and incentive salience attribution during adolescent development. We found that adolescent mice show increased reward seeking, impulsive action, and motivation. Interestingly, we found no effect of adolescence on impulsive choice, sign-tracking, reward-learning, or conditioned reinforcement. Overall, our studies set the stage for approaches to study multi-faceted phenotypes related to impulsivity and other reward-related behaviors in adolescent mice to examine the developmental trajectories of brain and behavior.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"115396"},"PeriodicalIF":2.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise performance effect of central dopamine is mediated by hypothalamic neuronal activation.","authors":"Quézia Teixeira Rodrigues, Lucas Rios Drummond, Paulo Marcelo Andrade Lima, Frederico Sander Mansur Machado, Helton Oliveira Campos, Raphael Escorsim Szawka, Laura Hora Rios Leite, Cândido Celso Coimbra","doi":"10.1016/j.bbr.2024.115406","DOIUrl":"10.1016/j.bbr.2024.115406","url":null,"abstract":"<p><p>Acting centrally, dopamine has been shown to induce ergogenic effects derived from its influence on thermoregulation, motivation, reward, and motor control. Thus, to evaluate the role of the central dopaminergic system in hypothalamic neuronal activation and its relationship with exercise performance, Wistar rats were intracerebroventricularly injected with saline (SAL) or SCH-23390 (SCH, dopamine D1 receptor blocker) at rest and before timed submaximal exercise (∼13 min) or exercise until fatigue. Core body and tail temperatures were recorded throughout the exercise. Hypothalamic Fos immunoreactivity (c-Fos-ir) expression was evaluated in thermoregulatory areas such as the median preoptic nucleus (MnPO), medial preoptic nucleus (MPO), paraventricular nucleus (PVN) and supraoptic nucleus (SON). Despite unchanged thermoregulatory adjustments, central D1 receptor blockade markedly decreased the exercise time and the workload performed until fatigue. Subsequently to timed exercise, D1 blockade increased neuronal activation in the MnPO, PVN, and SON. However, c-Fos-ir expression in the MnPO, MPO, PVN, and SON was similar between treated and control animals at fatigue. The data indicate that dopamine D1 receptors modulate exercise performance by altering hypothalamic neuronal activation elicited by exercise.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"480 ","pages":"115406"},"PeriodicalIF":2.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in oscillatory signaling dynamics in the prelimbic cortex and nucleus accumbens core during negative affect.","authors":"Pedro L Rodriguez-Echemendia, Regina M Carelli","doi":"10.1016/j.bbr.2024.115404","DOIUrl":"10.1016/j.bbr.2024.115404","url":null,"abstract":"<p><p>Affective processing is important for guiding behavior and its dysfunction can lead to several psychiatric illnesses, including depression and substance use disorders. Conditioned taste aversion (CTA) is used to study learned shifts in affect, and taste reactivity (TR) can effectively track the hedonic properties of appetitive and aversive tastants before and after CTA. While the infralimbic cortex (IL) and its projections to the nucleus accumbens (NAc) shell play a key role in learned negative affect, this role is unique to males. Here, we sought to determine if the prelimbic cortex (PrL) to nucleus accumbens (NAc) core circuit, another prefrontal cortex-accumbens system, tracks innate versus learned negative affect using electrophysiological (local field potential, LFP) methods in male and female rats. As expected, CTA elicited a hedonic shift from an appetitive to an aversive TR profile, regardless of sex. However, time-frequency analyses revealed differential activity in the PrL and NAc core during innate and learned negative affect across sex. Specifically, we found that beta oscillations in the NAc core encode learned negative affect in males, while neither brain region seems to be selectively attuned to innate or learned aversion in females. Importantly, LFP functional connectivity (coherence) indicated that the PrL-NAc core circuit does not track any aspect of learned negative affect in either sex but may be involved in innate aversion in males only. Collectively, these data provide a sex-specific understanding of real-time oscillatory signaling dynamics in the PrL and NAc core during innate versus learned negative affect.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"115404"},"PeriodicalIF":2.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attenuated task-responsive representations of hippocampal place cells induced by amyloid-beta accumulation.","authors":"Yimeng Wang, Xueling Wang, Ling Wang, Li Zheng, Xingwei An, Chenguang Zheng","doi":"10.1016/j.bbr.2024.115384","DOIUrl":"10.1016/j.bbr.2024.115384","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a typical neurodegenerative disease featuring deficits in spatial memory, which relies on spatial representations by hippocampal place cells. Place cells exhibit task-responsive representation to support memory encoding and retrieval processes. Yet, it remains unclear how this task-responsive spatial representation was interrupted under AD pathologies. Here, we employed a delayed match-to-place spatial memory task with associative and predictive memory processes, during which we electrophysiologically recorded hippocampal place cells with multi-tetrode hyperdrives in rats with i.c.v. amyloid/saline injection. We found that the directional selectivity of place cells coding was maintained in the Amyloid group. The firing stability was higher during predictive memory than during associative memory in both groups. However, the spatial specificity was decreased in the Amyloid group during both associative and predictive memory. Importantly, the place cells in the Amyloid group exhibited attenuated task-responsive representations, i.e. lack of spatial over-representations towards the goal zone and a higher representation of the rest zone, especially during the predictive memory stage. These results raise a hypothesis that the disrupted task-responsive representations of place cells could be an underlying mechanism of spatial memory deficits induced by amyloid proteins.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"115384"},"PeriodicalIF":2.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular and behavioral effects of Acamprosate in male rats with sodium salicylate-induced tinnitus.","authors":"Maryam Farrahizadeh, Saeid Mahmoudian, Zeinab Akbarnejad, Mohammad Taghi Joghataei, Mohammad Farhadi, Ali Shahbazi","doi":"10.1016/j.bbr.2024.115370","DOIUrl":"10.1016/j.bbr.2024.115370","url":null,"abstract":"<p><strong>Background: </strong>Imbalance in inhibitory and excitatory neurotransmitters have been reported in tinnitus. Acamprosate modulates the excitatory and inhibitory neurotransmission in the nucleus accumbens (NAc). This study aims to assess the effect of Acamprosate on tinnitus, anxiety, depression, and molecular changes in nucleus accumbens (NAc), in Sodium-Salisylate (S-salicylate) model of tinnitus.</p><p><strong>Methods: </strong>Forty-four adult male wistar rats were used in this study. The study included Control, Saline, and S-salicylate groups during the first week, which then subdivided into five groups as Control, Saline, S-salicylate, Acamprosate, and S-salicylate+Acamprosate. Gap-in Noise (GIN) and pre-pulse inhibition (PPI) were used to assessment of tinnitus at baseline, day7 and day14. Anxiety and depression were evaluated on day 14, by elevated plus maze (EPM), open field (OF), and tail suspension (TST) tests. The protein expression of GABAAR-δ, NR1 and NR2B in NAc were also measured using western blot technique.</p><p><strong>Results: </strong>After seven days GIN reduced in S-salicylate compare to Control and Saline groups (P < 0.5), while PPI unchanged. After 14 days, GIN reduced in S-salicylate and S-salicylate+Acamprosate groups compare to Control; Saline; and Acamprosate groups (P < 0.5). Additionally, GIN was higher in S-salicylate+Acamprosate compare to S-salicylate group (P < 0.5). PPI was not changed after 14 days. Open arm time in EPM test was decreased in S-salicylate and S-salicylate+Acamprosate groups compare to Control; Saline; and Acamprosate groups (P < 0.5). Central Zone time in OF test was reduced in S-salicylate group compare to Control, Saline, Acamprosate, and S-salicylate+Acamprosate groups (P < 0.5). Immobility Time in TST was increased in S-salicylate group compare to Control, Saline, Acamprosate, and S-salicylate+Acamprosate groups (P < 0.5). GABAAR-δ was decreased in S-salicylate groups compare to Control, Saline, Acamprosate; and S-salicylate+Acamprosate groups (P < 0.5). NR1 and NR2B in NAc were increased in S-salicylate group compare to Control, Saline, Acamprosate, and S-salicylate+Acamprosate groups (P < 0.5).</p><p><strong>Conclusion: </strong>S-salicylate can induce tinnitus-like behaviors in rat. Furthermore, S-salicylate induced depression/anxiety like behaviors, and changed the expression of GABAR and NMDAR subunits in NAc. Acamprosate partially reversed these changes. In conclusion, NAc may be involved in the pathophysiologic mechanisms of tinnitus.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"115370"},"PeriodicalIF":2.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of MAO‑B inhibitors in life quality of Parkinson's disease patients: A systematic review and meta‑analysis.","authors":"Xiaohuan Liu, Jiehua Su, Jieli Zhang, Zhonggui Li, Kaixun Huang, Danyu Lin, Enxiang Tao","doi":"10.1016/j.bbr.2024.115410","DOIUrl":"10.1016/j.bbr.2024.115410","url":null,"abstract":"<p><strong>Introduction: </strong>Monoamine oxidase-B (MAO-B) inhibitors, as an add-on therapy to levodopa, are widely used in Parkinson's disease (PD). The effects of MAO-B inhibitors on quality of life remain unclear, and the aim of this systematic review and meta-analysis was to assess the efficacy and safety of MAO-B inhibitors on quality of life in different domains.</p><p><strong>Methods: </strong>We searched PubMed, Embass, and Cochrane Library databases for randomized controlled trials of PD patients who were administered MAO-B inhibitors. Outcomes were the change from baseline in the total score of life quality scales, change from baseline in domains of the Parkinson's Disease Questionnaire-39 (PDQ-39), and incidence of treatment-associated adverse events (TAEs).</p><p><strong>Results: </strong>Sixteen studies covering 4734 PD patients were included in the study. The PDQ-39 scores were lower with MAO-B inhibitors than with placebo (SMD: -0.26, 95 % CI: [-0.49, -0.04], P = 0.02). The European Quality of Life Questionnaire-5D (EQ-5D) scores were higher in the MAO-B inhibitor group. Patients treated with MAO-B inhibitors had better performance in the domains of mobility, activities of daily living, emotional well-being, stigma, communication, and bodily discomfort, except for social support and cognition. The incidence of TAEs was slightly higher in patients treated with MAO-B inhibitors.</p><p><strong>Conclusions: </strong>Evidence has shown that MAO-B inhibitors, especially safinamide, are effective in improving the quality of life of PD patients, although with a slightly higher incidence of TAEs. The domains of quality of life were improved, except for cognition and social support, compared with placebo. Further studies are warranted to evaluate the effects of other MAO-B inhibitors on quality of life.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"115410"},"PeriodicalIF":2.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}