Electroacupuncture improves sleep deprivation-induced cognitive impairment by suppressing hippocampal inflammatory response in mice.

IF 2.6 4区心理学 Q2 BEHAVIORAL SCIENCES

Stress-The International Journal on the Biology of Stress Pub Date : 2025-12-01 Epub Date: 2025-05-21 DOI:10.1080/10253890.2025.2502742

Guoyan Li, Jingbo Liu, Kejing Zhang

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引用次数: 0

Abstract

Sleep deprivation (SD) is known to induce neurocognitive dysfunction, with hippocampal inflammation emerging as a critical mediator. Electroacupuncture has shown efficacy in modulating inflammation in neurological disorders, but its potential in mitigating SD-induced cognitive impairment remains underexplored. Using a murine model, we investigated the effects of electroacupuncture on hippocampal inflammation and cognitive function following SD treatment. BALB/c mice underwent sleep disruption using a multiple-platform apparatus and were subsequently treated with electroacupuncture. Cognitive function was assessed using the Morris Water Maze and Y-maze tests. Electroacupuncture treatment significantly ameliorated SD-induced cognitive impairment, as evidenced by improved performance in spatial memory tasks. Additionally, electroacupuncture attenuated hippocampal inflammation, characterized by reduced levels of pro-inflammatory cytokines (IL-1β, MCP-1 and TNF-α) and increased expression of the anti-inflammatory cytokine IL-10. Mechanistically, electroacupuncture suppressed microglial activation and inhibited the TLR4/NF-κB signaling pathway within the hippocampus. Electroacupuncture has therapeutic potential in mitigating SD-induced cognitive dysfunction by modulating hippocampal inflammation, which offers a promising non-pharmacological approach for preserving cognitive function in sleep-deprived individuals.

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电针通过抑制小鼠海马炎症反应改善睡眠剥夺引起的认知障碍。

睡眠剥夺（SD）可诱发神经认知功能障碍，海马炎症是一个重要的中介。电针已显示出调节神经系统疾病炎症的功效，但其在减轻sd诱导的认知障碍方面的潜力仍未得到充分探索。通过小鼠模型，我们研究了电针对SD治疗后海马炎症和认知功能的影响。BALB/c小鼠使用多平台仪器进行睡眠中断，随后进行电针治疗。采用Morris水迷宫和y形迷宫测试评估认知功能。电针治疗可以显著改善sd诱导的认知障碍，这可以通过提高空间记忆任务的表现来证明。此外，电针还能减轻海马炎症，其特征是促炎细胞因子（IL-1β、MCP-1和TNF-α）水平降低，抗炎细胞因子IL-10表达增加。在机制上，电针可抑制小胶质细胞的激活，抑制海马内TLR4/NF-κB信号通路。电针通过调节海马炎症，具有减轻sd诱导的认知功能障碍的治疗潜力，为保护睡眠剥夺患者的认知功能提供了一种有希望的非药物方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Stress-The International Journal on the Biology of Stress 医学-行为科学

CiteScore

5.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The journal Stress aims to provide scientists involved in stress research with the possibility of reading a more integrated view of the field. Peer reviewed papers, invited reviews and short communications will deal with interdisciplinary aspects of stress in terms of: the mechanisms of stressful stimulation, including within and between individuals; the physiological and behavioural responses to stress, and their regulation, in both the short and long term; adaptive mechanisms, coping strategies and the pathological consequences of stress. Stress will publish the latest developments in physiology, neurobiology, molecular biology, genetics research, immunology, and behavioural studies as they impact on the understanding of stress and its adverse consequences and their amelioration. Specific approaches may include transgenic/knockout animals, developmental/programming studies, electrophysiology, histochemistry, neurochemistry, neuropharmacology, neuroanatomy, neuroimaging, endocrinology, autonomic physiology, immunology, chronic pain, ethological and other behavioural studies and clinical measures.