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Can exosomes link the cellular and endocrine stress response? A test using the brown anole lizard (Anolis sagrei) as a model. 外泌体能否连接细胞和内分泌应激反应?一项以棕蜥(Anolis sagrei)为模型的测试。
IF 2.6 4区 心理学
Stress-The International Journal on the Biology of Stress Pub Date : 2025-12-01 Epub Date: 2025-05-29 DOI: 10.1080/10253890.2025.2509912
Nicole Rodriguez-Martinez, Anna Kaza, H Bobby Fokidis
{"title":"Can exosomes link the cellular and endocrine stress response? A test using the brown anole lizard (<i>Anolis sagrei</i>) as a model.","authors":"Nicole Rodriguez-Martinez, Anna Kaza, H Bobby Fokidis","doi":"10.1080/10253890.2025.2509912","DOIUrl":"https://doi.org/10.1080/10253890.2025.2509912","url":null,"abstract":"<p><p>Exosomes are nanoscale extracellular vesicles critical for intercellular communication, but their role in vertebrate stress responses remains unclear. We investigated exosome involvement in stress responses using brown anole lizards (<i>Anolis sagrei</i>), hypothesizing that acute stress would increase plasma exosome concentrations and inhibiting exosome secretion would attenuate the stress response. Using mixed-sex adult brown anoles (total <i>n</i> = 54 pairs), we conducted three experiments: a timed stress series, an adrenocorticotropic hormone (ACTH) challenge, and an exosome synthesis inhibitor (GW4869) challenge. Exosome concentrations were quantified using Nanoparticle Tracking Analysis and acetylcholinesterase (AChE) activity, while corticosterone levels were measured via enzyme-linked immunoassay (ELISA). Acute handling stress increased both plasma corticosterone and exosome concentrations, with a moderate significant correlation. ACTH injection elevated corticosterone but did not affect exosome levels. Blocking exosome synthesis with GW4869 significantly reduced corticosterone secretion, suggesting exosomes may play an indirect or concurrent role in stress regulation. This research provides the first <i>in vivo</i> evidence of exosomes' involvement in endocrine stress responses, offering a novel perspective on cellular stress signaling and potentially revealing an evolutionarily conserved mechanism of intercellular communication during stress adaptation.</p>","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"28 1","pages":"2509912"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the Impact of Person-Environment fit on Turnover Intention Through Multiple Linear Regression. 通过多元线性回归评估人与环境契合度对离职意向的影响
IF 1.6 4区 心理学
Psychological Reports Pub Date : 2025-12-01 Epub Date: 2023-12-12 DOI: 10.1177/00332941231219957
Kleinjan Redelinghuys
{"title":"Assessing the Impact of Person-Environment fit on Turnover Intention Through Multiple Linear Regression.","authors":"Kleinjan Redelinghuys","doi":"10.1177/00332941231219957","DOIUrl":"10.1177/00332941231219957","url":null,"abstract":"<p><p>Focusing on key antecedents of intended turnover may enable organizations to intervene before reaching scenarios where employee turnover is inevitable. The current study aimed to establish which type of fit plays the most prominent role in employees' turnover intention. To achieve this aim, multiple linear regression was used. By establishing which type of fit influences employees' thoughts of quitting the most, organizations can adopt better retention strategies as opposed to casting a net and hoping for the best. This cross-sectional study used secondary data from 384 retail employees. Three distinct fit scales and a turnover intention scale were administered. The study's hypothesis was assessed through multiple linear regression, relative weight analysis, and commonality analysis. Needs-supplies fit was the only variable that had a statistically significant negative association with turnover intention. Needs-supplies fit had the biggest contribution (23.64%) to the multiple <i>R</i><sup><i>2</i></sup> value (34.25%) of the multiple linear regression model. Commonality analysis showed that needs-supplies fit accounted for the highest percentage (16.85%) of unique variance in explaining turnover intention. To enhance the probability of retaining employees, organizations may want to fine-tune their retention strategies based on establishing congruence between what employees need and what can be done to meet these desired needs. The current study stresses the importance of distinguishing between different types of person-environment fit as they may not similarly relate to outcomes.</p>","PeriodicalId":21149,"journal":{"name":"Psychological Reports","volume":" ","pages":"4641-4662"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12480616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138808474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Prosocial Behaviour, Personality and General Mental Health in Predicting Emoji Use and Preference. 亲社会行为、人格和一般心理健康在预测表情符号使用和偏好中的作用。
IF 1.6 4区 心理学
Psychological Reports Pub Date : 2025-12-01 Epub Date: 2023-12-07 DOI: 10.1177/00332941231220304
Janine Carroll
{"title":"The Role of Prosocial Behaviour, Personality and General Mental Health in Predicting Emoji Use and Preference.","authors":"Janine Carroll","doi":"10.1177/00332941231220304","DOIUrl":"10.1177/00332941231220304","url":null,"abstract":"<p><p>Emojis are prevalent in text-based communication, but the factors that influence our use and preference for emojis remains unclear. This study investigated how emoji use and preference could be explained by three factors; mental health, personality and prosocial behaviour. A questionnaire consisting of five measures was completed by 222 participants and both Pearson correlations and multiple regressions were conducted on the data. The results showed prosocial behaviour significantly related to frequency, attitudes and motivations towards emoji use as well as to positive emoji preference. Agreeableness related to the frequency of emoji use. Extraversion related to both positive and negative emoji preference while conscientiousness and emotional stability significantly related to negative emoji preference only. General mental health significantly related to negative emoji preference. The regressions found all of the factors identified in the correlations predicted emoji use and preference with the exception of extraversion. Further research is needed to explore how the impact of the emotions depicted by emojis on these factors and to investigate how emojis are used by people with specific mental health conditions.</p>","PeriodicalId":21149,"journal":{"name":"Psychological Reports","volume":" ","pages":"4210-4226"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12480607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138499295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dominance Analysis of Bright and Dark Dispositional Predictors of Socially Desirable Responding. 社会理想反应的明暗倾向性预测因素的优势分析。
IF 1.6 4区 心理学
Psychological Reports Pub Date : 2025-12-01 Epub Date: 2024-01-08 DOI: 10.1177/00332941241226908
Brian K Miller, Eric G Kirby, Kaitlynn Brianna Stevens
{"title":"Dominance Analysis of Bright and Dark Dispositional Predictors of Socially Desirable Responding.","authors":"Brian K Miller, Eric G Kirby, Kaitlynn Brianna Stevens","doi":"10.1177/00332941241226908","DOIUrl":"10.1177/00332941241226908","url":null,"abstract":"<p><p>Although the role of so-called dark traits in the prediction of maladaptive behavior has seen a large increase in interest by researchers, the Big Five still maintain their ubiquity in the prediction of most behaviors. This study uses measures of the Dark Tetrad and the Big Five personality traits to predict a very specific form of maladaptive behavior: the impression management form of socially desirable responding. In regression-based dominance analysis, results suggest that not all of the Big Five nor the Dark Tetrad provide statistically significant incremental validity but as a block, the Big Five dominate the Dark Tetrad in the prediction of the purposeful misrepresentation of one's self to others on self-report inventories. More specifically, four of the Big Five as well as the traits of Machiavellianism and sadism from the Dark Tetrad are significant predictors of impression management.</p>","PeriodicalId":21149,"journal":{"name":"Psychological Reports","volume":" ","pages":"4799-4819"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139404167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of Pubertal Timing and Perceived Parental Attachment in Internalizing Problem Behaviours Among Adolescents. 青春期时间和感知到的父母依恋在青少年内化问题行为中的作用。
IF 1.6 4区 心理学
Psychological Reports Pub Date : 2025-12-01 Epub Date: 2024-01-08 DOI: 10.1177/00332941241226684
Palak Kanwar
{"title":"Role of Pubertal Timing and Perceived Parental Attachment in Internalizing Problem Behaviours Among Adolescents.","authors":"Palak Kanwar","doi":"10.1177/00332941241226684","DOIUrl":"10.1177/00332941241226684","url":null,"abstract":"<p><p>Adolescents need supportive social institutions to help them deal effectively with the demands of pubertal changes accompanied by new social roles, reducing their susceptibility to problem behaviors. Considering this, it will be investigated how internalizing problem behaviors in teenagers is affected by the interaction between pubertal timing and perceived parental attachment. For this, cross-sectional data from 772 adolescents with ages ranging from 11 to 15 years old was used. Regression analyses showed early maturing adolescents with insecure perceived parental attachments had higher levels of depression and anxiety than their early, on-time, and late maturing counterparts with secure perceived parental attachments. This finding supports the contextual amplification model, as the detrimental consequences of early maturation are impacted by difficult parent-adolescent relationships.</p>","PeriodicalId":21149,"journal":{"name":"Psychological Reports","volume":" ","pages":"4599-4616"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139404170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study of glucose homeostasis in burnout cases using an oral glucose tolerance test. 用口服葡萄糖耐量试验研究倦怠患者的葡萄糖稳态。
IF 2.6 4区 心理学
Stress-The International Journal on the Biology of Stress Pub Date : 2025-12-01 Epub Date: 2024-12-17 DOI: 10.1080/10253890.2024.2438699
Anna-Karin Lennartsson, Ingibjörg H Jonsdottir, Per-Anders Jansson, Anna Sjörs Dahlman
{"title":"Study of glucose homeostasis in burnout cases using an oral glucose tolerance test.","authors":"Anna-Karin Lennartsson, Ingibjörg H Jonsdottir, Per-Anders Jansson, Anna Sjörs Dahlman","doi":"10.1080/10253890.2024.2438699","DOIUrl":"https://doi.org/10.1080/10253890.2024.2438699","url":null,"abstract":"<p><p>Burnout is caused by long term psychosocial stress and has, besides the fatigue and mental health burden, been associated with increased risk of adverse physical health, such as for example type 2 diabetes. This study aims to investigate the glucose and insulin levels in individuals with stress related burnout, by assessing these metabolic markers in response to a standard oral glucose tolerance test (OGTT). 38 cases with burnout (13 men and 25 women) and 35 healthy controls (13 men and 22 women) in the age 24-55 were included in the study. The burnout group overall did not differ from healthy controls in glucose or insulin levels during the OGTT. However, the burnout cases who reported more severe burnout symptoms exhibited significantly higher levels of both glucose and insulin levels during the OGTT compared to burnout cases reporting lower severity of symptoms. Furthermore, the group of burnout cases who reported symptoms of depression exhibited higher insulin levels during OGTT compared to the burnout cases without depressive symptoms. The observed higher levels in the burnout cases with most severe symptoms indicate an increased diabetic risk in these patients and it may be of importance to follow glucose and insulin levels in individuals with more severe symptoms of burnout i.e. to perform an OGTT.</p>","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"28 1","pages":"2438699"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of the menstrual cycle phases and time of day on markers of stress: salivary α-amylase and secretory immunoglobulin A. 月经周期阶段和时间对应激指标的影响:唾液α-淀粉酶和分泌免疫球蛋白A。
IF 2.6 4区 心理学
Stress-The International Journal on the Biology of Stress Pub Date : 2025-12-01 Epub Date: 2025-01-05 DOI: 10.1080/10253890.2024.2449098
Josey K Walker, Courtney C Dillard, Drew E Gonzalez, Hunter S Waldman, Matthew J McAllister
{"title":"Impact of the menstrual cycle phases and time of day on markers of stress: salivary α-amylase and secretory immunoglobulin A.","authors":"Josey K Walker, Courtney C Dillard, Drew E Gonzalez, Hunter S Waldman, Matthew J McAllister","doi":"10.1080/10253890.2024.2449098","DOIUrl":"https://doi.org/10.1080/10253890.2024.2449098","url":null,"abstract":"<p><p>Previous reports suggest that the menstrual cycle (MC) phases can impact cortisol concentrations. However, research is needed on whether the MC impacts other markers of stress and immune function. It has also been shown that some biomarkers are impacted by time of day, although differences between morning (AM) and afternoon (PM) biomarkers have not been studied over the course of the MC. This study assessed the effect of MC phases and time of day on salivary stress biomarkers [salivary α-amylase (sAA), secretory immunoglobulin A (SIgA)], progesterone, resting blood pressure and resting heart rate (RHR). A single-group repeated measure design was employed in which seventeen participants (<i>n</i> = 17) monitored their MC for two months while attending eight experimental sessions which included both AM and PM sessions during each predicted 1) menses, 2) follicular, 3) ovulatory and 4) luteal phases. Resting blood pressures, heart rates, body composition parameters (assessed via bioelectrical impedance analysis), sAA and SIgA concentrations were assessed. No time of day x MC phase interactions (<i>p</i> > 0.05) were noted for sAA or SIgA, resting blood pressure, heart rate, or body composition parameters. However, sAA and RHR were significantly higher in the PM, while SIgA was significantly higher in the AM. These data suggest that the MC phases do not impact sAA or SIgA, resting blood pressure, heart rates, or body composition parameters. However, time-of-day impacts RHR and concentrations of sAA and SIgA. These findings provide implications for female participants in research dealing with these biomarkers.</p>","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"28 1","pages":"2449098"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular correlates of childhood adversity - a multi-omics perspective on stress regulation. 童年逆境的分子关联——应激调节的多组学视角。
IF 2.6 4区 心理学
Stress-The International Journal on the Biology of Stress Pub Date : 2025-12-01 Epub Date: 2025-04-30 DOI: 10.1080/10253890.2025.2495918
Johannes C S Zang, Caroline May, Katrin Marcus, Robert Kumsta
{"title":"Molecular correlates of childhood adversity - a multi-omics perspective on stress regulation.","authors":"Johannes C S Zang, Caroline May, Katrin Marcus, Robert Kumsta","doi":"10.1080/10253890.2025.2495918","DOIUrl":"https://doi.org/10.1080/10253890.2025.2495918","url":null,"abstract":"<p><p>The experience of adversity in childhood can have life-long consequences on health outcomes. In search of mediators of this relationship, alterations of bio-behavioral and cellular regulatory systems came into focus, including those dealing with basic gene regulatory processes. System biology oriented approaches have been proposed to gain a more comprehensive understanding of the complex multiple interrelations between and within layers of analysis. Here, we used co-expression based, supervised and unsupervised single and multi-omics systems approaches to investigate the association between childhood adversity and gene expression, protein expression and DNA methylation in CD14<sup>+</sup> monocytes in the context of psychosocial stress exposure, in a sample of healthy adults with (<i>n</i> = 29) or without (<i>n</i> = 27) a history of childhood adversity. Childhood adversity explained some variance at the single analyte level and within gene and protein co-expression structures. A single-omics, post-stress gene expression model differentiated best between participants with a history of childhood adversity and control participants in supervised analyses. In unsupervised analyses, a multi-omics based model showed best performance but separated participants based on sex only. Multi-omics analyses are a promising concept but might yield different results based on the specific approach taken and the omics-datasets supplied. We found that stress associated gene-expression pattern were most strongly associated with childhood adversity, and integrating multiple cellular layers did not results in better discriminatory performance in our rather small sample. The capacity and yield of different omics-profiling methods might currently limit the full potential of integrative approaches.</p>","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"28 1","pages":"2495918"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The TSST triggers self-reported stress and biological stress and frustrates basic psychological needs: general and specific buffering effects of physical activity and social support. TSST触发自我报告的压力和生物压力,挫败基本心理需求:体育活动和社会支持的一般和特定缓冲作用。
IF 2.6 4区 心理学
Stress-The International Journal on the Biology of Stress Pub Date : 2025-12-01 Epub Date: 2025-05-19 DOI: 10.1080/10253890.2025.2503984
Julia Schüler, Simona Rindelhardt, Beate Ditzen
{"title":"The TSST triggers self-reported stress and biological stress and frustrates basic psychological needs: general and specific buffering effects of physical activity and social support.","authors":"Julia Schüler, Simona Rindelhardt, Beate Ditzen","doi":"10.1080/10253890.2025.2503984","DOIUrl":"https://doi.org/10.1080/10253890.2025.2503984","url":null,"abstract":"<p><p>Situations characterized by uncontrollability and critical social evaluation frustrate basic psychological needs, as outlined in Self-Determination Theory (SDT). Uncontrollability and social evaluation are central elements of the Trier Social Stress Test (TSST), leading to the hypothesis that the TSST, in addition to increasing self-reported stress and cortisol responses, also frustrates the needs for autonomy, competence, and social relatedness. Participants (<i>N</i> = 195) reported elevated stress and reduced need satisfaction, and increased cortisol responses during the TSST. The roles of assessed physical activity and experimentally-induced social support were also examined. Indeed, in time-sensitive and specific manner, the TSST frustrated basic psychological needs. Social support however mitigated frustration of social relatedness. Physical activity buffered against self-reported stress, the frustration of competence and the cortisol response. Further research is recommended to explore more differentiated interventions that can counteract the negative effects of psychosocial stressors.</p>","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"28 1","pages":"2503984"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adverse childhood experiences (ACEs) and repeated wheezing from 6 to 30 months of age: exploring the role of race and ethnicity. 不良童年经历(ace)和6至30个月大的反复喘息:探索种族和民族的作用。
IF 2.6 4区 心理学
Stress-The International Journal on the Biology of Stress Pub Date : 2025-12-01 Epub Date: 2025-03-12 DOI: 10.1080/10253890.2025.2477530
Francheska M Merced-Nieves, Marina Schechter, Elena Colicino, Allison Frost, Rosalind J Wright
{"title":"Adverse childhood experiences (ACEs) and repeated wheezing from 6 to 30 months of age: exploring the role of race and ethnicity.","authors":"Francheska M Merced-Nieves, Marina Schechter, Elena Colicino, Allison Frost, Rosalind J Wright","doi":"10.1080/10253890.2025.2477530","DOIUrl":"10.1080/10253890.2025.2477530","url":null,"abstract":"<p><p>Identifying children at risk for respiratory disorders involves understanding early risk factors. This study prospectively examines how specific types of early adversity influence childhood wheeze and how these vary by race and ethnicity. Analyses included N = 746 mother-infant dyads from an urban pregnancy cohort. Mothers completed the Lifetime Stressor Checklist-Revised (LSC-R), Edinburgh Postnatal Depression Scale (EPDS), Spielberger State-Trait Anxiety Inventory (STAI), Posttraumatic stress disorder Checklist-Civilian version (PCL-C), and Traumatic Events Screening Inventory (TESI) when infants were 6 months old to assess adverse childhood experiences (ACEs). Mothers reported child wheeze at 4-month intervals to index wheezing episodes from age 6-30 months. We first assessed independent associations between ACE measures and wheeze frequency using Poisson regression. We then used weighted quantile sum (WQS) regression to derive an ACEs mixture index to estimate joint associations with wheeze frequency in the overall sample and stratified by maternal race and ethnicity adjusting for child sex, maternal asthma and education. There was a 2.05 increase (95% CI = 1.21, 3.49) in wheeze frequency with each quintile increase of the ACEs index in Black/Black Hispanics; the TESI (72%) contributed most strongly to the mixture. In non-Black Hispanics, there was a 1.33 (95% CI = 1.05, 1.67) increase in wheeze frequency with each ACEs quintile increase with EPDS (76%) contributing most strongly. Findings support the need to move the ACEs paradigm beyond a simple cumulative score when examining effects on early respiratory disease risk. Results also highlight how the impact of early life ACEs varies by ethnoracial identity.</p>","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"28 1","pages":"2477530"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12011106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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