Xiaoye Michael Wang, Michael Nitsche, Gabby Resch, Ali Mazalek, Timothy N Welsh
{"title":"Mixed reality alters motor planning and control.","authors":"Xiaoye Michael Wang, Michael Nitsche, Gabby Resch, Ali Mazalek, Timothy N Welsh","doi":"10.1016/j.bbr.2024.115373","DOIUrl":"10.1016/j.bbr.2024.115373","url":null,"abstract":"<p><p>Compared to physical unmediated reality (UR), mixed reality technologies, such as Virtual (VR) and Augmented (AR) Reality, entail perturbations across multiple sensory modalities (visual, haptic, etc.) that could alter how actors move within the different environments. Because of the mediated nature, goal-directed movements in VR and AR may rely on planning and control processes that are different from movements in UR, resulting in less efficient motor control. The current study involved participants performing manual pointing movements on Müller-Lyer illusion stimuli to examine the relative contributions of movement planning and online control in UR, VR, and AR. Compared to UR, movements in VR were slower but were equally variable with a comparable level of online control, whereas movements in AR showed comparable speed but exhibited higher variability and less online control. Further, movements in VR and AR demonstrated a greater illusory effect in endpoint accuracy relative to UR. These findings suggested that participants in VR adopted an active compensation strategy to overcome the impact of less efficient online control, whereas participants in AR did not. The findings that movement planning and execution in VR and AR are fundamentally different from those in UR provide valuable insights into the potential neural systems engaged during movements in different realities.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"115373"},"PeriodicalIF":2.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Different responses of MVL neurons when pigeons attend to local versus global information during object classification.","authors":"Minjie Zhu, Yedong Yang, Xiaoke Niu, Yanyan Peng, Ruibin Liu, Mengbo Zhang, Yonghao Han, Zhizhong Wang","doi":"10.1016/j.bbr.2024.115363","DOIUrl":"10.1016/j.bbr.2024.115363","url":null,"abstract":"<p><p>Most prior studies have indicated that pigeons have a tendency to rely on local information for target categorization, yet there is a lack of electrophysiological evidence to support this claim. The mesopallium ventrolaterale (MVL) is believed to play a role in processing both local and global information during visual cognition. The difference between responses of MVL neurons when pigeons are focusing on local versus global information during visual object categorization remain unknown. In this study, pigeons were trained to categorize hierarchical stimuli that maintained consistency in local and global information. Subsequently, stimuli with different local and global components were presented to examine the pigeons' behavioral preferences. Not surprisingly, the behavioral findings revealed that pigeons predominantly attended to the local elements when performing categorization tasks. Moreover, MVL neurons exhibited significantly distinct responses when pigeons prioritized local versus global information. Specifically, most recording sites showed heightened gamma band power and increased nonlinear entropy values, indicating strong neural responses and rich information when pigeons concentrated on the local components of an object. Furthermore, neural population functional connectivity was weaker when the pigeons focused on local elements, suggesting that individual neurons operated more independently and effectively when focusing on local features. These findings offer electrophysiological evidence supporting the notion of pigeons displaying a behavioral preference for local information. The study provides valuable insight into the understanding of cognitive processes of pigeons when presented with complex objects, and further sheds light on the neural mechanisms underlying pigeons' behavioral preference for attending to local information.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"115363"},"PeriodicalIF":2.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Social-defeat stress exposure during pregnancy induces abnormalities in spontaneous activity, sociality, and resilience to stress in offspring of mice.","authors":"Tamaki Yabe, Yuko Mitsui, Momoka Ohnishi, Rena Tanigawa, Mizuki Tanizaki, Rei Sugiyama, Niina Kiriyama, Airi Otsuka, Komada Munekazu","doi":"10.1016/j.bbr.2024.115367","DOIUrl":"10.1016/j.bbr.2024.115367","url":null,"abstract":"<p><strong>Background: </strong>Environmental stress during prenatal periods can lead to neurodevelopmental disorders. Psychosocial stress can be studied using the social-defeat stress (SDS) animal model. However, the effects of prenatal exposure to SDS on the behavior of mature offspring mice have not been clarified. The present study assessed the spontaneous activity and social interaction of pups born to mothers exposed to SDS during gestation, as well as their post-maturity responses to environmental stimuli, focusing on changes in anxiety-like behavior following restraint stress exposure.</p><p><strong>Methods: </strong>Pregnant C57BL/6 J mice were subjected to SDS for 4 days, from E12.5-E15.5, using aggressive male ICR mice. We assessed the mature offspring (after 10 weeks of age) born to these mothers for spontaneous activity, anxiety-like behavior, and social interactions, and evaluated their activity levels post-maturity following restraint stress exposure.</p><p><strong>Results: </strong>The open field test (OF) indicated reduced travel distance and duration in the SDS group versus controls, whereas home-cage monitoring showed increased area traveled. In a novel environment, the SDS group showed a decrease in interest in stranger mice. In a multiple-animal rearing environment, the SDS group showed an increase in the frequency and number of contact with other individuals. Movement duration in the OF following restraint stress reduced significantly from 30 min to 4 h in the control versus SDS group.</p><p><strong>Conclusions: </strong>Prenatal exposure to SDS can result in behavior resembling developmental disorders, impacting spontaneous activity and social interactions. Altered responses to stress suggest potential brain function abnormalities in offspring after maturation due to maternal SDS exposure.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"115367"},"PeriodicalIF":2.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142778813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aubrey M Demchuk, Ingrid M Esteves, Bruce L McNaughton
{"title":"Non-maternal nest building behaviours in mice predict bilateral dorsal hippocampal lesion extent.","authors":"Aubrey M Demchuk, Ingrid M Esteves, Bruce L McNaughton","doi":"10.1016/j.bbr.2024.115366","DOIUrl":"10.1016/j.bbr.2024.115366","url":null,"abstract":"<p><p>Lesions and pharmacological inactivation of the hippocampus have long been important tools for assessing the critical role of the hippocampus in learning and memory. Such studies often require a substantial investment of time and resources and, so, a tool for estimating lesion extent and screening animals prior to histological verification would be of considerable utility. Mice with bilateral hippocampal lesions have previously been observed to be deficient at nest building. Therefore, non-maternal nest construction was assessed as a predictor of the extent of hippocampal lesions. Mice with complete bilateral dorsal hippocampal lesions (comprising >50 % of the total volume of both hippocampi) exhibited severe deficits in nest building, failing to shred and/or gather nesting materials. In contrast, incomplete dorsal hippocampal lesions were not sufficient to cause impairments. Overall, among both male and female mice, nest construction score was highly positively correlated with the total volume of intact dorsal hippocampus. Importantly, reduced nesting behaviours could not be explained by gross motor deficits, which were evaluated by running performance on a non-motorized treadmill. Altogether, spontaneous nest building behaviour was confirmed to be a simple, cost-effective, and reliable predictor of bilateral dorsal hippocampal lesion extent in an otherwise healthy mouse strain.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"115366"},"PeriodicalIF":2.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142778870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yu-Fu Chen, Chih-Yu Tsao, Yuh-Tarng Chen, Ho-Ching Chang, Wai-Yu Li, Jui-Lin Chiang, Chien-Fu Fred Chen, Chia-Hsiang Chen, Susan Shur-Fen Gau, Kuang-Yung Lee, Li-Jen Lee, Yu-Chun Wang
{"title":"Altered odor perception in Dlgap2 mutant mice, a mouse model of autism spectrum disorder.","authors":"Yu-Fu Chen, Chih-Yu Tsao, Yuh-Tarng Chen, Ho-Ching Chang, Wai-Yu Li, Jui-Lin Chiang, Chien-Fu Fred Chen, Chia-Hsiang Chen, Susan Shur-Fen Gau, Kuang-Yung Lee, Li-Jen Lee, Yu-Chun Wang","doi":"10.1016/j.bbr.2024.115365","DOIUrl":"10.1016/j.bbr.2024.115365","url":null,"abstract":"<p><p>Olfactory dysfunction has been observed in patients with Autism Spectrum Disorder (ASD). A microdeletion at the 8p23 terminal regions of chromosome 8p23 was identified in a Taiwanese patient with ASD, suggesting a potential association with mutations in the DLGAP2 gene. DLGAP2 is expressed in the olfactory bulb in rodents. The current study investigated olfactory phenotypes of Dlgap2 mutant mice. The results indicated that odor detection capabilities were comparable between wild-type (WT) and Dlgap2 mutant mice. However, homozygous mutant (Homo) mice showed less interest in sniffing odors of banana and almond but greater sniffing activity in response to bedding from unfamiliar cages. Notably, exposure to banana odor elicited significant c-fos expression in most olfaction-related brain regions of WT mice, while Homo mice did not show much increase in c-fos levels in major olfactory areas, which may correlate with their diminished sniffing behavior. Bedding stimuli induced pronounced c-fos expression in WT brains and some olfaction-related regions, including the olfactory bulb, amygdala, hypothalamus, and medial prefrontal cortex, in Homo mice. These mutants may still process olfactory signals from the bedding through a relatively narrow channel, which might elicit their interest, leading to increased sniffing behaviors that may compensate for their olfactory deficits. The DLGAP2 protein was absent in the olfactory bulb of Homo mice, and the levels of PSD95 and CaMKIIβ were also affected, indicating alterations in synaptic transmission and signaling within the olfactory system. This study evaluated olfactory perception in a mouse model of ASD, which may advance diagnostic and therapeutic strategies.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"115365"},"PeriodicalIF":2.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Farah Wahida Suhaimi, Nurul Husna Mohamad Khari, Zurina Hassan, Christian P Müller
{"title":"Exploring the cognitive effects of kratom: A review.","authors":"Farah Wahida Suhaimi, Nurul Husna Mohamad Khari, Zurina Hassan, Christian P Müller","doi":"10.1016/j.bbr.2024.115387","DOIUrl":"10.1016/j.bbr.2024.115387","url":null,"abstract":"<p><p>Despite the strict kratom regulation in some regions, the demand for kratom products is still increasing worldwide. Kratom products are commonly consumed for their pain-relieving effect or as a self-treatment for opioid use disorder. Kratom is also taken as a recreational drug among youth and adults. Since substance abuse can cause cognitive impairment, many studies investigated the effects of kratom on cognition. The interaction of some kratom alkaloids with various receptors such as opioid, serotonergic, and adrenergic receptors further sparks the interest to investigate the effects of kratom on cognitive function. Hence, this review aims to provide an overview of the effects of kratom on cognitive behaviours and their underlying changes in neurobiological mechanisms. In conclusion, kratom, particularly its main alkaloid, mitragynine may adversely affect cognitive performances that may be attributed to the disruption in synaptic plasticity, brain activity as well as various proteins involved in synaptic transmission. The impact of kratom on cognitive functions could also shed light on its safety profile, which is essential for the therapeutic development of kratom, including its potential use in opioid substitution therapy.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"115387"},"PeriodicalIF":2.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fabio Pilato, Davide Norata, Maria Grazia Rossi, Vincenzo Di Lazzaro, Rosalinda Calandrelli
{"title":"Consciousness disturbance in patients with chronic kidney disease: Rare but potentially treatable complication. Clinical and neuroradiological review.","authors":"Fabio Pilato, Davide Norata, Maria Grazia Rossi, Vincenzo Di Lazzaro, Rosalinda Calandrelli","doi":"10.1016/j.bbr.2024.115393","DOIUrl":"10.1016/j.bbr.2024.115393","url":null,"abstract":"<p><p>In patients with chronic kidney disease, particularly those in end-stage kidney failure and undergoing dialysis treatment, brain complications may arise, and their potential reversibility mainly hinges on timely diagnosis and intervention. Neurological symptoms may be non-specific ranging from slight or pronounced consciousness disturbance till coma, and imaging is the main tool to guide diagnosis and may reveal the underlying pathophysiological mechanism. Kidney impairment, causing a surge in blood pressure, increases the risk of Posterior Reversible Encephalopathy Syndrome and, leads to neurochemical alterations that result in uremic encephalopathy. In end-stage kidney failure patients, Posterior Reversible Encephalopathy Syndrome predominantly occurs in atypical locations, often involving the bilateral basal ganglia, and exhibit larger volumes compared to patients without kidney dysfunction. Uremic encephalopathy may involve the basal ganglia, white matter, and cortical or subcortical regions; in the latter case, imaging features resemble the typical location of Posterior Reversible Encephalopathy Syndrome. Dialysis Disequilibrium Syndrome, Osmotic Demyelination Syndrome, and Wernicke's encephalopathy are uncommon complications associated with dialysis. Each syndrome manifests distinct imaging patterns: Dialysis Disequilibrium Syndrome shows bilateral, patchy, diffuse white matter alterations; Osmotic Demyelination Syndrome causes central pontine and less often extrapontine lesions (involving bilateral basal ganglia, thalamus, and cerebral peduncles); Wernicke's encephalopathy determines symmetrical abnormalities in the thalamus, mammillary bodies, periaqueductal gray matter, midbrain tectal plate but the nature of brain edema associated with these complications remains controversial. Besides, in rare cases, overlapping imaging features may occur, and only the accurate patient's clinical history reconstruction along with laboratory examination results can lead to a better evaluation of MRI findings and underlying causes allowing prompt therapy.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"115393"},"PeriodicalIF":2.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Isabela da Silva Lemos, Carolina Giassi Alano, Rafael Orestes Canarim, Ellen De Pieri, Maria Eduarda Mendes Botelho, Catharina de Bem Ribeiro, Pauline Souza Effting, Ricardo Andrez Machado-de-Ávila, Gislaine Zilli Réus, Guilhian Leipnitz, Emilio Luiz Streck
{"title":"Donepezil treatment mitigates cholinergic system alterations, oxidative stress, neuroinflammation and memory impairment induced by branched-chain amino acid administration in rats.","authors":"Isabela da Silva Lemos, Carolina Giassi Alano, Rafael Orestes Canarim, Ellen De Pieri, Maria Eduarda Mendes Botelho, Catharina de Bem Ribeiro, Pauline Souza Effting, Ricardo Andrez Machado-de-Ávila, Gislaine Zilli Réus, Guilhian Leipnitz, Emilio Luiz Streck","doi":"10.1016/j.bbr.2024.115359","DOIUrl":"10.1016/j.bbr.2024.115359","url":null,"abstract":"<p><p>Maple Syrup Urine Disease (MSUD) is an inherited metabolic disorder biochemically characterized by tissue accumulation of leucine, isoleucine, and valine and their derivatives. Patients present with neurological disabilities and treatment is limited. Donepezil, a drug used for neurodegenerative disorders, has been shown to improve memory and counteract oxidative stress and inflammation. In the present study, we investigated whether donepezil administration could improve alterations in the cholinergic system, oxidative stress, inflammation, and behavior changes in rats submitted to a chemical MSUD model based on the administration of branched-chain amino acids (BCAA) leucine, isoleucine, and valine. Our results showed a decrease in short- and long-term memory in the object recognition task in rats submitted to BCAA administration. We also verified an increase in acetylcholinesterase (AChE) activity and a decrease in choline acetyltransferase in the cerebral cortex of the BCAA control group. Increased reactive species production, alterations in the antioxidant defenses, and inflammation were further observed. Additionally, we found that donepezil treatment attenuated alterations in AChE activity, reactive species production, lipids oxidative damage, inflammation, and memory. Our findings contribute to the understanding of the pathophysiology of MSUD and suggest that donepezil is a potential pharmacological treatment for this disorder.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"115359"},"PeriodicalIF":2.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shakiba Salarvandian, Hadi Digaleh, Fariba Khodagholi, Pegah Javadpour, Sareh Asadi, Amir Ali Orang Zaman, Leila Dargahi
{"title":"Harmonic activity of glutamate dehydrogenase and neuroplasticity: The impact on aging, cognitive dysfunction, and neurodegeneration.","authors":"Shakiba Salarvandian, Hadi Digaleh, Fariba Khodagholi, Pegah Javadpour, Sareh Asadi, Amir Ali Orang Zaman, Leila Dargahi","doi":"10.1016/j.bbr.2024.115399","DOIUrl":"10.1016/j.bbr.2024.115399","url":null,"abstract":"<p><p>In recent years, glutamate has attracted significant attention for its roles in various brain processes. However, one of its key regulators, glutamate dehydrogenase (GDH), remains understudied despite its pivotal role in several biochemical pathways. Dysfunction or dysregulation of GDH has been implicated in aging and various neurological disorders, such as Alzheimer's disease and Parkinson's disease. In this review, the impact of GDH on aging, cognitive impairment, and neurodegenerative conditions, as exemplars of the phenomena that may affected by neuroplasticity, has been reviewed. Despite extensive research on synaptic plasticity, the precise influence of GDH on brain structure and function remains undiscovered. This review of existing literature on GDH and neuroplasticity reveals diverse and occasionally conflicting effects. Future research endeavors should aim to describe the precise mechanisms by which GDH influences neuroplasticity (eg. synaptic plasticity and neurogenesis), particularly in the context of human aging and disease progression. Studies on GDH activity have been limited by factors such as insufficient sample sizes and varying experimental conditions. Researchers should focus on investigating the molecular mechanisms by which GDH modulates neuroplasticity, utilizing various animal strains and species, ages, sexes, GDH isoforms, brain regions, and cell types. Understanding GDH's role in neuroplasticity may offer innovative therapeutic strategies for neurodegenerative and psychiatric diseases, potentially slowing the aging process and promoting brain regeneration.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"115399"},"PeriodicalIF":2.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiaomin Xu, Stevan Nikolin, Adriano H Moffa, Mei Xu, Thanh Vinh Cao, Colleen K Loo, Donel M Martin
{"title":"Effects of repetitive transcranial magnetic stimulation combined with cognitive training for improving response inhibition: A proof-of-concept, single-blind randomised controlled study.","authors":"Xiaomin Xu, Stevan Nikolin, Adriano H Moffa, Mei Xu, Thanh Vinh Cao, Colleen K Loo, Donel M Martin","doi":"10.1016/j.bbr.2024.115372","DOIUrl":"10.1016/j.bbr.2024.115372","url":null,"abstract":"<p><strong>Background: </strong>Impaired response inhibition is a common characteristic of various psychiatric disorders. Cognitive training (CT) can improve cognitive function, but the benefits may be limited. Repetitive transcranial magnetic stimulation (rTMS) is a promising tool to enhance neuroplasticity, and thereby augment the effects of CT. We aimed to investigate the augmentation effects of rTMS on CT for response inhibition in healthy participants.</p><p><strong>Methods: </strong>Sixty healthy participants were randomly assigned to two experimental groups: one with prolonged intermittent theta burst stimulation (iTBS) + CT and the other with sham iTBS + CT over four experimental sessions. Prolonged iTBS (1800 pulses) was used to stimulate the right inferior frontal cortex (rIFC) and pre-supplementary motor area (pre-SMA) in a counterbalanced order. Participants completed a Stop Signal training task following iTBS over one brain region, followed by the Go/No-Go training task after iTBS over the other brain region. The Stroop task with concomitant electroencephalography was conducted before and immediately after the intervention.</p><p><strong>Results: </strong>There were no significant differences between groups in behavioural outcomes on the Stop Signal task, Go/No-Go task, Stroop task or Behavior Rating Inventory of Executive Functioning for Adults. Similarly, analysis of event-related potentials (ERPs) from the Stroop task (N200 and N400) and exploratory cluster-based permutation analysis did not reveal any significant differences between groups. Subgroup analyses revealed that individuals with higher baseline impulsivity exhibited better learning effects in the active group.</p><p><strong>Conclusions: </strong>This first proof of concept study did not find evidence that four sessions of active rTMS + CT could induce cognitive or neurophysiological effects on response inhibition in healthy participants. However, subgroup analyses suggests that rTMS combined with CT could be useful in improving response inhibition in individuals with high impulsivity. It is recommended that future proof of concept studies examine its potential in this clinical population.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"480 ","pages":"115372"},"PeriodicalIF":2.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}