Behavioural PharmacologyPub Date : 2025-10-01Epub Date: 2025-08-21DOI: 10.1097/FBP.0000000000000850
Stephen W White, Tara D Clover, Kenneth J Sufka
{"title":"Synbiotic diet produces antidepressant-like effects but alters ketamine activity in an avian model of treatment-resistant depression.","authors":"Stephen W White, Tara D Clover, Kenneth J Sufka","doi":"10.1097/FBP.0000000000000850","DOIUrl":"10.1097/FBP.0000000000000850","url":null,"abstract":"<p><p>Pre- and probiotics promote a diverse and functional gut microbiota and have demonstrated both anxiolytic and antidepressant effects; however, how synbiotic diet interacts with antidepressant medications has not been fully investigated. This study sought to evaluate the potential anxiolytic or antidepressant effects of a synbiotic diet in an avian model that presents homologies with treatment-resistant depression. In addition, we sought to evaluate the potential interaction of a synbiotic diet combined with select doses of ketamine. Socially raised Black Australorp chicks were given either standard or synbiotic feed for 7 days. At 7 days posthatch, chicks from each feed condition were administered either 0, 5, or 10 mg/kg/ml ketamine 15 min before a 90-min isolation stressor, which elicits distress vocalizations (DVocs) that temporally represent a panic-like phase followed by a depression-like phase. Saline-treated chicks given the synbiotic diet displayed significantly higher DVoc rates in the depression-like phase compared with saline-treated animals in the standard feed condition, indicative of attenuation of behavioral despair [F(1,22) = 5.45, P < 0.05]. Similarly, in the standard diet condition, ketamine 10 mg/kg produced elevated DVoc rates; however, under the synbiotic diet, both doses of ketamine produced a suppression of DVoc rates in the depression-like phase. These findings suggest that a synbiotic diet produces antidepressant-like effects in the model and a possible negative interaction between synbiotics and ketamine. While preliminary, the findings suggest the concurrent use of pre- and probiotic supplements and ketamine may produce contradictory effects and warrant further investigation.</p>","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"36 7","pages":"526-533"},"PeriodicalIF":1.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stay calm in crowds: Avoiding emotional faces in ensemble perception.","authors":"Xin Luo, Megan Bartlett, Michael E R Nicholls","doi":"10.3758/s13414-025-03124-4","DOIUrl":"10.3758/s13414-025-03124-4","url":null,"abstract":"<p><p>Previous research has shown that people tend to display attentional biases toward faces with strong emotions within crowds, often overestimating the extremity of the average emotional expression. However, this emotional amplification effect has not been consistently observed in tasks where observers summarize other crowd features, such as the number of faces. This study aims to explore the attentional mechanisms underlying these inconsistent findings. To do so, we recruited 584 participants across four online experiments and employed an equivalence judgment task to assess participants' ability to estimate the number of emotional faces. In the task, participants determined whether the number of two types of facial expressions within a series of crowds was the \"same\" or \"different.\" Experiment 1 revealed that the number of emotional faces (angry and happy) was underestimated relative to neutral faces. Experiment 2 replicated this underestimation effect across different face types and exposure durations. Experiment 3 demonstrated that the emotional amplification effect may be caused by strong emotion contrasts within crowds. Experiment 4 confirmed that the underestimation of the number of emotional faces could be replicated in the numerosity estimation task with different instructions. Our findings suggest that people may strategically suppress attention to emotional faces to mitigate their emotional response. This study provides important empirical evidence to enhance our understanding of the cognitive processes underlying emotion perception and social behavior.</p>","PeriodicalId":55433,"journal":{"name":"Attention Perception & Psychophysics","volume":" ","pages":"2223-2240"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"On the Role of Police Shootings, Recognition of Systemic Racism, and Empathy on White Americans' Support for Police Reform.","authors":"Diane-Jo Bart-Plange, Sophie Trawalter","doi":"10.1177/01461672241237286","DOIUrl":"10.1177/01461672241237286","url":null,"abstract":"<p><p>The police kill Black Americans at disproportionate rates. Despite this, White Americans remain mixed on support for policing-related policy reform. We examined whether bearing witness to police violence leads to support for policy reforms. Across three studies (<i>N</i> = 943), White participants either viewed a news video about an unarmed Black man killed at the hands of police or in a car accident due to a collision with another driver. Participants lower but not higher in symbolic racism reported more empathy after viewing a police shooting (vs. car accident) news video (Studies 1-3). Empathy predicted policing-related policy reform support (Studies 1-3) and mediated the relationship between condition and policy reform support (Studies 1 and 3), among those lower in symbolic racism (Studies 1-2). Results suggest that empathy for Black victims of police violence predicts policy support but only among those who recognize that such violence is systemic in nature.</p>","PeriodicalId":19834,"journal":{"name":"Personality and Social Psychology Bulletin","volume":" ","pages":"1962-1986"},"PeriodicalIF":2.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140306343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Does Conceptual Abstraction Moderate Whether Past Moral Deeds Motivate Consistency or Compensatory Behavior? A Registered Replication and Extension of Conway and Peetz (2012).","authors":"Jareef Martuza, Olivia Kim","doi":"10.1177/01461672241238420","DOIUrl":"10.1177/01461672241238420","url":null,"abstract":"<p><p>A long-standing debate in psychology concerns whether doing something good or bad leads to more of the same or the opposite. Conway and Peetz proposed that <i>conceptual abstraction</i> moderates if past moral deeds lead to consistent or compensatory behavior. Although cited 384 times across disciplines, we did not find any direct replications. It was also unclear how increases or decreases from one's baseline prosociality might underlie the effect. A large-scale experiment (<i>N</i> = 5,091) in the registered report format tested Conway and Peetz's original hypothesis. The hypothesized interaction was <i>not</i> replicated: conceptual abstraction did not moderate the effect of recalling moral vs. immoral behavior on prosocial intentions. Our results show that recalling moral behavior led to higher prosocial intentions than recalling either immoral or neutral behavior, irrespective of recalling from the recent or distant past. Thus, the current research found no evidence for compensatory moral behavior, only for positive moral consistency.</p>","PeriodicalId":19834,"journal":{"name":"Personality and Social Psychology Bulletin","volume":" ","pages":"2002-2014"},"PeriodicalIF":2.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140306341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"\"Not Now, I Am Too Stressed\": Stress and Physical Intimacy in Early Marriage.","authors":"Alyssa M Sucrese, Lisa A Neff, Marci E J Gleason","doi":"10.1177/01461672241239134","DOIUrl":"10.1177/01461672241239134","url":null,"abstract":"<p><p>Stressful events can disrupt couples' emotional connection, yet prior research is mixed regarding whether stress also disrupts couples' physical intimacy. This study considered whether stress must reach a critical threshold before hindering couples' sexual activity and physical affection (i.e., a curvilinear association). Couples (<i>N =</i> 144 couples plus four additional wives) completed two 14-day daily diary tasks during the early years of marriage. Multilevel modeling revealed a within-person curvilinear association between daily stress and sexual activity. Contrary to expectations, the likelihood of sexual activity declined as stress increased from low to moderate, then leveled off as stress continued to increase. For physical affection, a linear effect emerged. On days of greater stress, women, but not men, reported less affection. Further analyses suggested that women's stress is more influential than men's stress for couple's physical intimacy. Findings highlight the nuanced ways in which stress is linked to a vital component of satisfying relationships.</p>","PeriodicalId":19834,"journal":{"name":"Personality and Social Psychology Bulletin","volume":" ","pages":"1927-1941"},"PeriodicalIF":2.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140288744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"People Reject Free Money and Cheap Deals Because They Infer Phantom Costs.","authors":"Andrew J Vonasch, Reyhane Mofradidoost, Kurt Gray","doi":"10.1177/01461672241235687","DOIUrl":"10.1177/01461672241235687","url":null,"abstract":"<p><p>If money is good, then shouldn't more money always be better? Perhaps not. Traditional economic theories suggest that money is an ever-increasing incentivizer. If someone will accept a job for US$20/hr, they should be more likely to accept the same job for US$30/hr and especially for US$250/hr. However, 10 preregistered, high-powered studies (<i>N</i> = 4,205, in the United States and Iran) reveal how increasing incentives can backfire. Overly generous offers lead people to infer \"phantom costs\" that make them less likely to accept high job wages, cheap plane fares, and free money. We present a theory for understanding when and why people imagine these hidden drawbacks and show how phantom costs drive judgments, impact behavior, and intersect with individual differences. Phantom costs change how we should think about \"economic rationality.\" Economic exchanges are not merely about money, but instead are social interactions between people trying to perceive (and deceive) each others' minds.</p>","PeriodicalId":19834,"journal":{"name":"Personality and Social Psychology Bulletin","volume":" ","pages":"2050-2067"},"PeriodicalIF":2.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12361704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140865047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The effect of lithium on behavioral functions in adolescent rats exposed to chronic unpredictable mild stress with respect to brain-derived neurotrophic factor and glycogen synthase kinase-3 beta levels in the prefrontal cortex.","authors":"Maryam Abbasi Mehmandost Sofla, Mahdie Gholami, Salar Vaseghi, Nooshin Barikrow, Batool Ghorbani-Yekta","doi":"10.1097/FBP.0000000000000842","DOIUrl":"10.1097/FBP.0000000000000842","url":null,"abstract":"<p><p>Chronic unpredictable mild stress (CUMS) is widely used as a reliable method to induce depressive states and anhedonia in rodents. Lithium is one of the well-known drugs used for the alleviation of symptoms in different neuropsychiatric disorders such as depression and bipolar disorder. In this research, we evaluated the efficacy of several doses of lithium on behavioral changes induced by CUMS. Also, the expression level of brain-derived neurotrophic factor (BDNF) and glycogen synthase kinase-3 beta (GSK-3beta) in the prefrontal cortex was evaluated. CUMS was done using various unpredictable stressors for 14 days. Lithium was injected at the doses of 10, 30, and 50 mg/kg. Locomotor activity, anxiety-like behavior, pain perception, and depressive-like behavior were assessed using the open field test, the novelty-suppressed feeding test, the hot plate test, and the forced swim test, respectively. The results revealed that CUMS decreased locomotor activity, increased anxiety- and depressive-like behaviors, increased pain threshold, decreased climbing, decreased BDNF level, and increased GSK-3beta level in the prefrontal cortex. However, lithium dose-dependently restored all these effects. In control rats, lithium (50 mg/kg) decreased locomotion and GSK-3beta expression levels. In conclusion, the results suggested that deleterious effects of CUMS may be mediated via BDNF and GSK-3beta in the prefrontal cortex, and lithium via suppressing GSK-3beta and upregulating BDNF expression levels in the prefrontal cortex can restore CUMS effects.</p>","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"471-483"},"PeriodicalIF":1.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ethan S Young, Stefan Vermeent, Willem E Frankenhuis, Marissa D Nivison, Jeffry A Simpson, Glenn I Roisman
{"title":"How does adversity relate to performance across different abilities within individuals?","authors":"Ethan S Young, Stefan Vermeent, Willem E Frankenhuis, Marissa D Nivison, Jeffry A Simpson, Glenn I Roisman","doi":"10.1017/S0954579424001433","DOIUrl":"10.1017/S0954579424001433","url":null,"abstract":"<p><p>The idea that some abilities might be enhanced by adversity is gaining traction. Adaptation-based approaches have uncovered a few specific abilities enhanced by particular adversity exposures. Yet, for a field to grow, we must not dig too deep, too soon. In this paper, we complement confirmatory research with principled exploration. We draw on two insights from adaptation-based research: 1) enhanced performance manifests within individuals, and 2) reduced and enhanced performance can co-occur. Although commonly assumed, <i>relative</i> performance differences are rarely tested. To quantify them, we need a wide variety of ability measures. However, rather than using adaptive logic to predict which abilities are enhanced or reduced, we develop statistical criteria to identify three data patterns: reduced, enhanced, and intact performance. With these criteria, we analyzed data from the National Institute of Child Health and Human Development Study of Early Child Care and Youth Development to investigate how adversity shapes within-person performance across 10 abilities in a cognitive and achievement battery. Our goals are to document adversity-shaped cognitive performance patterns, identify drivers of reduced performance, identify sets of \"intact\" abilities, and discover new enhanced abilities. We believe principled exploration with clear criteria can help break new theoretical and empirical ground, remap old territory, and advance theory development.</p>","PeriodicalId":11265,"journal":{"name":"Development and Psychopathology","volume":" ","pages":"1859-1876"},"PeriodicalIF":3.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AssessmentPub Date : 2025-10-01Epub Date: 2024-11-10DOI: 10.1177/10731911241283410
Andy C Dean, Jean-Baptiste Pochon, Robert M Bilder, Fred W Sabb, Eliza Congdon, Dara Ghahremani, Katherine H Karlsgodt, Theo G M van Erp, Rebecca F Schwarzlose, Tyrone D Cannon, Nelson B Freimer, Edythe D London
{"title":"Convergent Validity of Experimental Cognitive Tests in a Large Community Sample.","authors":"Andy C Dean, Jean-Baptiste Pochon, Robert M Bilder, Fred W Sabb, Eliza Congdon, Dara Ghahremani, Katherine H Karlsgodt, Theo G M van Erp, Rebecca F Schwarzlose, Tyrone D Cannon, Nelson B Freimer, Edythe D London","doi":"10.1177/10731911241283410","DOIUrl":"10.1177/10731911241283410","url":null,"abstract":"<p><p>Experimental cognitive tests are designed to measure particular cognitive domains, although evidence supporting test validity is often limited. The Consortium for Neuropsychiatric Phenomics test battery administered 23 experimental and traditional neuropsychological tests to a large sample of community volunteers (<i>n</i> = 1,059) and patients with psychiatric diagnoses (<i>n</i> = 137), providing a unique opportunity to examine convergent validity with factor analysis. Traditional tests included subtests from the Wechsler and Delis-Kaplan batteries, while experimental tests included the Attention Networks Test, Balloon Analogue Risk Task, Delay Discounting Task, Remember-Know, Reversal Learning Task, Scene Recognition, Spatial and Verbal Capacity and Manipulation Tasks, Stop-Signal Task, and Task Switching. Several experimental cognitive measures were insufficiently related to other tests and were excluded from factor analyses. In the remaining 18 tests, exploratory factor analysis and subsequent multigroup confirmatory factor analysis supported a three-factor structure broadly corresponding to domains of verbal/working memory, inhibitory control, and memory. In sum, several experimental measures of inhibitory control had weak relationships with all other tests, while the convergent validity of most tests of working memory and memory was supported.</p>","PeriodicalId":8577,"journal":{"name":"Assessment","volume":" ","pages":"1008-1026"},"PeriodicalIF":3.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12397545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amanda Thompson, Donna Ruch, Jeffrey A Bridge, Cynthia Fontanella, Theodore P Beauchaine
{"title":"Self-injury and suicidal behaviors in high-risk adolescents: Distal predictors, proximal correlates, and interactive effects of impulsivity and emotion dysregulation.","authors":"Amanda Thompson, Donna Ruch, Jeffrey A Bridge, Cynthia Fontanella, Theodore P Beauchaine","doi":"10.1017/S0954579424001342","DOIUrl":"10.1017/S0954579424001342","url":null,"abstract":"<p><p>Suicide rates are rising among U.S. youth, yet our understanding of developmental mechanisms associated with increased suicide risk is limited. One high-risk pathway involves an interaction between heritable trait impulsivity and emotion dysregulation (ED). Together, these confer increased vulnerability to nonsuicidal self-injury (NSSI), suicide ideation (SI), and suicide attempts (SAs). Previous work, however, has been limited to homogeneous samples. We extend the Impulsivity × ED hypothesis to a more diverse sample of adolescents (<i>N</i> = 344, ages 12-15 at Baseline, 107 males and 237 females) who were treated for major depression and assessed four times over two years. In multilevel models, the impulsivity × ED interaction was associated with higher levels and worse trajectories of NSSI, SI, and SAs. As expected, stressful life events were also associated with poorer trajectories for all outcomes, and NSSI was associated with future and concurrent SI and SAs. These findings extend one developmental pathway of risk for self-harming and suicidal behaviors to more diverse adolescents, with potential implications for prevention.</p>","PeriodicalId":11265,"journal":{"name":"Development and Psychopathology","volume":" ","pages":"1742-1755"},"PeriodicalIF":3.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}