Journal of clinical and experimental neuropsychology最新文献

{"title":"Averaged 22-month test-retest reliability of non-computerized baseline cognitive assessments in healthy youth athletes.","authors":"Michael Ellis-Stockley, Jennifer S Adler, Daniel Baldini, Rayna B Hirst","doi":"10.1080/13803395.2025.2503252","DOIUrl":"https://doi.org/10.1080/13803395.2025.2503252","url":null,"abstract":"<p><strong>Objective: </strong>Neuropsychological baseline evaluations in youth are critical in the context of sport concussion management. Youth athletes typically undergo annual baseline evaluations to account for the rapid cognitive development that occurs throughout childhood. However, the reliability of measures used in baseline evaluations at an interval greater than one year is relatively unknown. This study examined the test-retest reliability of non-computerized neuropsychological assessments administered at different time points and aimed to provide neuropsychologists with data to inform their decisions in test selection and clinical interpretation.</p><p><strong>Method: </strong>Healthy youth male athletes (<i>n</i> = 28, M_age = 11.24 years) completed two comprehensive baseline evaluations on average 22.67 months apart. The intraclass correlation coefficient measured test-retest reliability, and a mixed effects model examined the degree of improvement in test scores and within-subject variability across administrations using both raw and normative scores.</p><p><strong>Results: </strong>Measures of visuoconstruction, cognitive switching, working memory, contextualized verbal memory, inhibition, and simple attention produced good reliability (>.75), while a measure of visual memory demonstrated poor reliability (<.50) for both normed and raw scores. The authors observed significant interactions between age and time elapsed between baseline administrations for measures of visuoconstruction, visual processing speed, and cognitive switching. Normed scores for measures of working memory, simple attention, and inhibition showed more within-subject variability than raw scores.</p><p><strong>Conclusions: </strong>All measures, except NEPSY-II Memory for Designs, demonstrated moderate to good test-retest reliability for both absolute and normed scores over an average 22-month interval between baseline administrations. However, clinicians should not overlook potential practice effects when interpreting a youth athlete's second baseline performance. The authors also underscore the value of examining raw data in understanding of cognitive maturation across cognitive domains. Future research should examine the reliability of baseline evaluations incorporating both non-computerized and computerized measures, and replicate findings in a larger sample of youth athletes.</p>","PeriodicalId":15382,"journal":{"name":"Journal of clinical and experimental neuropsychology","volume":" ","pages":"1-12"},"PeriodicalIF":1.8,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the functional utility of the Advanced Clinical Solutions-Social Perception Affect Naming subtest in treatment-resistant psychosis.","authors":"Jessica Lau, Ivan Caramanna, Daniah Zumrawi, Brianne Glazier, Mahesh Menon, Olga Leonova, William G Honer, Randall F White, Ivan Torres","doi":"10.1080/13803395.2025.2505582","DOIUrl":"https://doi.org/10.1080/13803395.2025.2505582","url":null,"abstract":"<p><strong>Introduction: </strong>Despite the recognized importance of social cognition in predicting functional outcomes in schizophrenia, there is a lack of widely accepted measures that assess this broad domain while possessing psychometric validity and predictive utility. This study aimed to address this gap by providing incremental validity data for a promising social cognitive measure assessing facial affect recognition in patients presenting with treatment-resistant psychosis.</p><p><strong>Method: </strong>Using a clinical archival dataset comprising 59 consecutive admissions to an inpatient treatment-resistant psychosis unit, this study examined facial affect naming performance from the Advanced Clinical Solutions-Social Perception (ACS-SP) affect naming subtest, and the association with neuropsychological functioning and symptom severity. Hierarchical regression models were used to assess whether facial affect recognition predicted daily functioning, including measures of functional capacity and functional performance.</p><p><strong>Results: </strong>The ACS-SP affect naming measure showed limited sensitivity for impairment relative to other cognitive domains. Affect naming showed weak to moderate correlations with a broad range of non-memory cognitive functions, and no association with symptom severity. After controlling for cognitive functioning and symptoms, the ACS-SP affect naming task predicted poorer functioning with regard to functional performance but not functional capacity.</p><p><strong>Conclusions: </strong>The ACS-SP affect naming task associates weakly to moderately with other measures of cognition, but also likely taps into social cognitive skills not measured by typical neuropsychological tests. This measure was predictive of some aspects of functional outcomes in patients with treatment-resistant psychosis, and therefore may be a useful tool to incorporate into routine neuropsychological assessments in such treatment settings.</p>","PeriodicalId":15382,"journal":{"name":"Journal of clinical and experimental neuropsychology","volume":" ","pages":"1-15"},"PeriodicalIF":1.8,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How autism impacts children's working memory for faces.","authors":"Shahrzad M Esfahan, Narges Sepahi, Ehsan Rezayat","doi":"10.1080/13803395.2025.2505585","DOIUrl":"https://doi.org/10.1080/13803395.2025.2505585","url":null,"abstract":"<p><p>This study investigates visual working memory (WM) performance in children aged 7-12 years with Autism Spectrum Disorder (ASD) compared to typically developing (TD) peers, focusing on face stimuli to evaluate social-relevant memory processing. The research aims to identify differences in visual WM functioning and determine whether errors in recall stem from reduced precision or increased random guessing. Participants completed a visual WM task requiring them to memorize and reproduce the orientations of faces presented on a screen. Results demonstrated that children with ASD exhibited significantly poorer overall visual WM accuracy than TD children. A fine-grained analysis of error patterns revealed that the ASD group showed markedly lower precision in recalling spatial details of the stimuli, indicating less stable or detailed memory representations. However, rates of random guessing-a measure of attentional lapses or task disengagement-did not differ significantly between groups. These findings underscore that visual WM deficits in ASD are primarily driven by reduced precision rather than fluctuations in attention or motivation. The study highlights the importance of precision-based mechanisms in understanding atypical cognitive profiles in ASD, offering insights into potential interventions targeting memory consolidation or perceptual encoding strategies to enhance functional outcomes. By isolating precision as a key deficit, this work advances theoretical models of visual WM and informs tailored approaches to support memory-related challenges in ASD.</p>","PeriodicalId":15382,"journal":{"name":"Journal of clinical and experimental neuropsychology","volume":" ","pages":"1-9"},"PeriodicalIF":1.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of direct-to-home teleneuropsychological evaluations in U.S. Veterans with functional seizures.","authors":"Ryan Van Patten, Catherine D DeCesare, Lawrence Chan, Krista Colling, Kristina Goode, Alison Gorbatov, Noah S Philip, W Curt LaFrance","doi":"10.1080/13803395.2025.2503251","DOIUrl":"https://doi.org/10.1080/13803395.2025.2503251","url":null,"abstract":"<p><strong>Introduction: </strong>Functional seizures (FS) present with cognitive dysfunction that impacts quality of life, suggesting that neuropsychological evaluations would be beneficial. However, these patients often face barriers to in-person appointments, leading to a gap in care. The current study objective is to examine aspects of feasibility of direct-to-home (DtH) teleneuropsychology for patients with FS.</p><p><strong>Method: </strong>U.S. Veterans with FS were prospectively recruited from a national VA program from October 2023 to February 2025. Participants completed DtH cognitive testing and neurological/mental health assessments. We measured satisfaction with teleneuropsychology using an adapted questionnaire. We implemented a Seizure Safety Protocol to direct management of acute events. Descriptive analyses report on relevant feasibility metrics.</p><p><strong>Results: </strong>Of 60 referrals, 22 participants (37%) consented. Of those 22 participants, 20 (91%) completed the full study. Two of 22 (9%) participants were discontinued partway through data collection due to prolonged symptoms following a seizure. Five participants experienced 11 total seizures during the study, but these events did not appear to impact the validity of test data, with a few exceptions (11/720 [<2%] missing cognitive test indices). Satisfaction with the telehealth study was high such that 20/22 (91%) participants agreed or strongly agreed that they were satisfied with the study overall. Participants reported enjoying the convenience, safety, and comfort of the DtH method, although some preferred traditional in-person sessions.</p><p><strong>Conclusions: </strong>Findings support the use of teleneuropsychology in FS. A Seizure Safety Protocol can provide guidance on handling presumed medical emergencies and can mitigate risk of invalid cognitive data. Neuropsychologists may consider declining to use telehealth if seizures are common and likely to lead to (i) the request for acute medical care and/or (ii) prolonged symptoms that interfere with the assessment. More widespread use of teleneuropsychology for patients with FS in the future may improve access to beneficial clinical services.</p>","PeriodicalId":15382,"journal":{"name":"Journal of clinical and experimental neuropsychology","volume":" ","pages":"1-16"},"PeriodicalIF":1.8,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilizing clinical assessment databases to enhance clinical training and research in neuropsychology: benefits, challenges, and practical strategies.","authors":"Anthony D Robinson, John-Christopher A Finley","doi":"10.1080/13803395.2025.2503253","DOIUrl":"https://doi.org/10.1080/13803395.2025.2503253","url":null,"abstract":"<p><p>Research serves as the foundation of clinical neuropsychology, and strengthening research training pipelines is critical to sustaining innovation and scientific rigor within the field. Clinical assessment databases are one promising tool for achieving this goal. Herein, we describe the benefits and challenges of implementing clinical assessment databases across various neuropsychology training settings. First, we highlight their benefits, including the promotion of a standardized approach to clinical training, improvements in patient care, and increased opportunities for research. Next, we describe how clinical databases can be implemented across various training settings, including university-affiliated psychology training clinics, academic medical centers, Veterans Affairs hospitals, and private practice settings. The potential roles of faculty, trainees, and administrative staff in supporting database development and use are discussed. Lastly, we address practical strategies for overcoming implementation challenges, such as balancing both clinical and research demands, obtaining institutional review board approval, selecting appropriate data storage platforms, and ensuring data quality and consistency. Specific recommendations regarding platform storage are provided along with cost considerations. By integrating clinical assessment databases, neuropsychology training clinics can enhance their ability to provide evidence-based clinical training, deliver high quality care, and enhance research training. Although implementing clinical databases presents technical, logistical, and ethical challenges, these can be managed with careful planning.</p>","PeriodicalId":15382,"journal":{"name":"Journal of clinical and experimental neuropsychology","volume":" ","pages":"1-10"},"PeriodicalIF":1.8,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropsychological and central neurologic effects of cancer immunotherapy: the start of a new challenge.","authors":"Florence Joly, Hélène Castel, Annette Compter, Celeste Nicola, Mylène Duivon, Marie Lange","doi":"10.1080/13803395.2025.2498713","DOIUrl":"10.1080/13803395.2025.2498713","url":null,"abstract":"<p><strong>Introduction: </strong>Cognitive difficulties are frequently reported after cancer treatments, such as chemotherapy or hormone therapy, and have a negative impact on patients' quality of life. Recently, some studies have shown that new cancer treatments, such as immunotherapy agents, can induce cognitive changes.</p><p><strong>Method: </strong>This review presents the central neurological immune adverse events of immunotherapy treatments including Immune Checkpoint Inhibitors (ICI) and Chimeric Antigen Receptor (CAR) T-cell therapy. The physiopathological mechanisms and risk factors are developed and clinical studies on immunotherapy agents and cognition (among adult patients, using validated questionnaires and/or cognitive tests), psychological factors and quality of life were presented.</p><p><strong>Results: </strong>Neurological toxicities are frequently observed with CAR-T cell therapies at acute stage, such as the immune effector cell-associated neurotoxicity syndrome (ICANS), inducing cognitive disorders such as disorientation and aphasia. However, few studies have accurately assessed the impact of immunotherapy on cognition. The methodology of these studies is heterogeneous and they mainly included nonspecific self-report questionnaires of cognitive complaints. Variable results have been obtained concerning the cognitive impact of ICI and CAR-T cell several months following immunotherapy: overall, while some studies reported cognitive difficulties (mainly processing speed and executive functions), the majority has not. Although anxiety and depression are frequently reported in patients treated with ICI or CAR-T cells, these symptoms tend to decrease after the start of immunotherapy. The current neurobiological investigations are too fragmentary to explain neurological symptoms and potential cognitive alteration, but neuroinflammation, vascular inflammation, brain blood barrier disruption, and immune cell brain infiltration would constitute common mechanisms relayed by CAR-T and to a lesser degree, ICI.</p><p><strong>Conclusions: </strong>Acute neurological toxicities following CAR-T cell therapies are a major issue. Further studies are needed to better assess cognitive difficulties after the initiation of immunotherapy, in particular ICI, to better understand the physiopathology, including imaging studies, and risk factors.</p>","PeriodicalId":15382,"journal":{"name":"Journal of clinical and experimental neuropsychology","volume":" ","pages":"1-20"},"PeriodicalIF":1.8,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortical auditory evoked potentials in the identification and monitoring of learning disorders: a systematic review and meta-analysis.","authors":"Ali Hajimohammadi, Sajad Khodabandelu, Fatemeh Heidari, Sara Khaleghi","doi":"10.1080/13803395.2025.2499867","DOIUrl":"https://doi.org/10.1080/13803395.2025.2499867","url":null,"abstract":"<p><strong>Introduction: </strong>Approximately 5-10% of the population faces learning disorders (LDs) and encounter difficulties with tasks like reading, writing, and processing auditory information. One method used to assess auditory information processing in the brain is by measuring cortical auditory evoked potentials (CAEPs). This study aims to explore whether abnormalities in CAEPs could serve as clinical indicator for the early diagnosis of LDs, and if modifications in these components could be beneficial in tracking neural changes following intervention in individuals with LDs.</p><p><strong>Method: </strong>The systematic literature search followed the PRISMA guideline. Two independent reviewers searched five electronic databases (Medline, Science Direct, Cochrane, Google Scholar, and ProQuest) from their inception to 16 April 2024, using relevant keywords.</p><p><strong>Results: </strong>Upon assessing the quality of articles and applying inclusion and exclusion criteria, 22 studies were selected for analysis. The majority of these studies observed delayed latency and reduced amplitude of CAEP components in individuals with LDs. The results of the meta-analysis emphasized delayed latency, particularly a significant delay in the N2 component, as the most prominent distinction between the LD and control groups. Additionally, certain studies have reported therapeutic interventions resulting in improved latency and amplitude of CAEPs in the LD population.</p><p><strong>Conclusion: </strong>Based on the findings, the presence of an abnormal CAEP pattern, characterized by delayed component latencies, may serve as a potential indicator for LDs, assisting in the early identification of this disorder, and assessment of CAEPs can be used to evaluate the effectiveness of therapeutic interventions for individuals with LDs.</p>","PeriodicalId":15382,"journal":{"name":"Journal of clinical and experimental neuropsychology","volume":" ","pages":"1-18"},"PeriodicalIF":1.8,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using digital platforms to address inequities in neuropsychology training and education: lessons learned from KnowNeuropsychology.","authors":"Anny Reyes, Julia E Maietta, Christina G Wong, Beatriz MacDonald, Matthew Calamia, Alexander Tan, Joshua T Fox-Fuller, Willie F McBride, Amanda Gooding, Lucas D Driskell, Victor A Del Bene, Scott A Sperling, Emily C Murriel, Cady Block","doi":"10.1080/13803395.2025.2497303","DOIUrl":"https://doi.org/10.1080/13803395.2025.2497303","url":null,"abstract":"<p><p>Traditional neuropsychology training models in the United States and other Westernized countries rely on structured graduate programs, clinical experiences, and postdoctoral fellowships. However, access to neuropsychology education is often inequitable, hindered by limited coursework availability, geographic barriers to learning and practice opportunities, and systemic disparities affecting underrepresented groups. The COVID-19 pandemic further exposed these gaps, disrupting in-person clinical training and educational opportunities. KnowNeuropsychology was established in response to these challenges in 2020, with the goal of providing freely accessible virtual neuropsychology lectures to an international audience. Although KnowNeuropsychology was initially launched as a 12-week webinar series to address training disruptions caused by the pandemic, it has evolved into a nonprofit organization offering over 100 high-quality didactics on diverse clinical and research topics in neuropsychology, including clinical disorders, cultural diversity (among other aspects), neuroanatomy, and professional development. KnowNeuropsychology prioritizes diversity, equity, and inclusion by amplifying voices from underrepresented groups, students, and early career professionals and ensuring accessible, culturally relevant content. The platform has achieved a global reach by leveraging virtual tools and addressing training gaps in low- and middle-income countries and underserved regions. Lessons learned from KnowNeuropsychology underscore the potential of digital tools to expand access to neuropsychology education and inform systemic changes, aligning with updated training guidelines to increase equity and inclusion in the field.</p>","PeriodicalId":15382,"journal":{"name":"Journal of clinical and experimental neuropsychology","volume":" ","pages":"1-15"},"PeriodicalIF":1.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of executive function and language abilities in explaining theory of mind development in preschool-age children.","authors":"Michael Luc Andre, Célia Maintenant","doi":"10.1080/13803395.2025.2498712","DOIUrl":"https://doi.org/10.1080/13803395.2025.2498712","url":null,"abstract":"<p><p>The development of theory of mind is linked to executive functions and language abilities in preschool-age children. Its relationship with these two cognitive variables has been studied from two research perspectives, providing a clear theoretical view on the links between theory of mind and executive functions on the one hand, and theory of mind and language on the other. However, the link between these three variables together has only recently been studied through a single research question and few data exist. This study therefore aimed to assess to what extent executive functions and language abilities contribute to theory of mind development. A sample of 112 children between 3 and 6-years old completed three language tasks from the ELO (Batterie d'Evaluation du Langage Oral) test: a receptive and an expressive vocabulary task and a syntax understanding task, the Wellman and Liu scale as a theory of mind task and three executive function tasks, namely the grass/snow task to measure inhibition, the DCCS (Dimensional Change Card Sort) to evaluate cognitive flexibility and the WPPSI (Wechsler Preschool and Primary Scale Intelligence) to assess working memory. The findings revealed significant correlations between theory of mind and executive function domains, except for cognitive flexibility. Theory of mind and all language variables were also found to be significantly correlated. Multiple regression analyses justified only syntax and general language abilities as possible explanatory factors of the children's theory of mind performance. These findings support the view that language, more specifically syntax, is an important explanatory factor of theory of mind in young children. Theoretical implications of these finding are discussed.</p>","PeriodicalId":15382,"journal":{"name":"Journal of clinical and experimental neuropsychology","volume":" ","pages":"1-13"},"PeriodicalIF":1.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using objective and subjective measures of mind wandering to predict progression to development of cognitive impairment and test associations with Alzheimer disease biomarkers.","authors":"Matthew S Welhaf, David A Balota, Suzanne E Schindler, John C Morris, Jason Hassenstab, Andrew J Aschenbrenner","doi":"10.1080/13803395.2025.2498025","DOIUrl":"https://doi.org/10.1080/13803395.2025.2498025","url":null,"abstract":"<p><strong>Introduction: </strong>Mind wandering decreases in healthy aging, and in some cases, it is further reduced in Alzheimer disease (AD). However, little is known about how mind wandering changes during the preclinical phase of AD, which is a critical period for intervention. The present study aims to provide novel evidence for the utility of objective and subjective measures of mind wandering in evaluating the risk of developing cognitive impairment and their association with AD biomarkers.</p><p><strong>Methods: </strong>Participants (<i>N</i> = 504; M_age = 69.54 years, SD_age = 8.95 years) completed a Sustained Attention to Response Task (SART). We calculated objective (reaction time coefficient of variation; RT CoV) and subjective (self-reported frequency of off-task thoughts) mind wandering measures during the SART for participants who remained cognitively stable (<i>N</i> = 349) and those who eventually developed cognitive impairment (progressors; <i>N</i> = 155). A subset of participants (<i>N</i> = 211) completed the SART annually and had recent CSF biomarkers.</p><p><strong>Results: </strong>Objective and subjective mind wandering significantly differed between progressors and cognitively stable participants at baseline and predicted likelihoods of progression. Moreover, baseline subjective mind wandering predicted progression beyond standard neuropsychological measures. Longitudinal models indicated that biomarker negative, but not positive, participants showed a significant reduction in RT CoV over time, possibly reflecting practice-related changes in performance. There were no longitudinal associations with subjective mind wandering.</p><p><strong>Conclusions: </strong>Mind wandering is a common activity and may reflect a healthy cognitive system in older age. Subjective measures of mind wandering may be useful in predicting the later onset of cognitive impairment, while objective measures may be more sensitive to longitudinal changes.</p>","PeriodicalId":15382,"journal":{"name":"Journal of clinical and experimental neuropsychology","volume":" ","pages":"1-16"},"PeriodicalIF":1.8,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}