Davide Bruno, Chelsea Reichert-Plaska, Ainara Jauregi-Zinkunegi, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Nunzio Pomara
{"title":"Associations of plasma p-tau231 with serial position recall performance in free-of-dementia individuals.","authors":"Davide Bruno, Chelsea Reichert-Plaska, Ainara Jauregi-Zinkunegi, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Nunzio Pomara","doi":"10.1111/jnp.70012","DOIUrl":"https://doi.org/10.1111/jnp.70012","url":null,"abstract":"<p><p>Cognitive assessment and analysis of plasma biomarkers are lower-cost options for the early assessment of Alzheimer's disease (AD). In this study, we examined whether serial position markers in the Rey's AVLT were sensitive to plasma AD biomarkers in cognitively unimpaired older individuals. Participants (n = 327; mean age = 70.4, SD = 10.4) were free of dementia (MMSE = 24+) at baseline and recruited as part of the Memory Evaluation Research Initiative (MERI; Nathan Kline Institute, NY, USA). Data included plasma p-tau231, Aβ40 and Aβ42, AVLT scores and demographics. Bayesian linear and logistic regression analyses were carried out with plasma biomarkers as outcomes (including the Aβ42/40 ratio); memory scores, including traditional metrics and serial position scores, were predictors; and age, years of education, APOE ε4-status and reported gender were control variables. Results indicated that plasma p-tau231 was associated primarily with delayed primacy recall (first four words): the more primacy words were recalled, the lower the plasma p-tau231 levels were. This study confirms that serial position analysis of word-list recall data, and particularly delayed primacy, is a valuable tool for the identification of in vivo AD-related pathology in cognitively unimpaired individuals.</p>","PeriodicalId":197,"journal":{"name":"Journal of Neuropsychology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145129724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luis Heredia, María Marco, Nerea Carrión, Margarita Torrente
{"title":"Frontal Assessment Battery: Reliability, validity and discriminative ability in a Spanish sample of amnestic mild cognitive impairment and Alzheimer's disease.","authors":"Luis Heredia, María Marco, Nerea Carrión, Margarita Torrente","doi":"10.1111/jnp.70011","DOIUrl":"https://doi.org/10.1111/jnp.70011","url":null,"abstract":"<p><p>Dementia constitutes one of the most widespread neurological disorders, representing an important health concern due to its increasing prevalence. Among the various types of dementia, Alzheimer's disease (AD) is the most common in the elderly, characterized by episodic memory impairment and also a decline in executive functions. Mild cognitive impairment (MCI) is considered a transitional stage between normal ageing and dementia, often described as a pre-dementia state. Distinguishing between these states is of paramount importance for the detection and appropriate care of patients. Functional Assessment Battery (FAB) is a screening tool for assessing executive function. In this study, 36 healthy individuals (HC), 31 single-domain amnestic mild cognitive impairment (aMCI) patients, and 29 Alzheimer's disease (AD) patients were assessed using FAB to determine its reliability, validity, and discriminative validity in a Spanish sample. Results indicated a good internal consistency of FAB in the AD sample (α = .71), but not in the aMCI group (α = .49). Significant differences between HC and both aMCI and AD groups were observed in the total scores of FAB. The FAB also showed good accuracy in distinguishing between HC and patients (AUC = 0.85), with an estimated optimal cut-off point of 16.5. However, its ability to distinguish between aMCI and AD individuals was lower (AUC = 0.68). More studies are necessary to corroborate our results using larger samples.</p>","PeriodicalId":197,"journal":{"name":"Journal of Neuropsychology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ondrej Bezdicek, Jiří Motýl, Tomáš Nikolai, Adéla Fendrych Mazancová, Jakub Hort, Robert Jech, Martin Vyhnálek, Hana Horáková
{"title":"Differential cued recall memory impairment in mild cognitive impairment due to Alzheimer's disease versus Parkinson's disease.","authors":"Ondrej Bezdicek, Jiří Motýl, Tomáš Nikolai, Adéla Fendrych Mazancová, Jakub Hort, Robert Jech, Martin Vyhnálek, Hana Horáková","doi":"10.1111/jnp.70010","DOIUrl":"https://doi.org/10.1111/jnp.70010","url":null,"abstract":"<p><p>Both Alzheimer's (AD) and Parkinson's disease (PD) are often associated with memory dysfunction, but their pathophysiological underpinnings differ. The current research aimed to differentiate specific profiles of memory impairment due to AD versus PD. We used controlled learning and cued recall paradigm based on the Memory Binding Test (MBT) in 'clinically cognitively normal' controls (CN; n = 161), in patients with amnestic mild cognitive impairment due to AD (AD-aMCI; n = 50) and due to PD (PD-MCI; n = 22), and in PD with normal cognition (n = 18) as based on performance in the neuropsychological battery to prevent circularity in diagnostic decision-making. We applied analysis of covariance (ANCOVA) and Receiver Operating Characteristic (ROC) analysis to determine between-group differences and detection potential of the MBT. We found statistically large between-group differences with worse memory performance in paired cued recall conditions in AD-aMCI<PD-MCI; AD-aMCI<PD-NC; AD-aMCI<CN (p < .001 after Bonferroni correction), and to a lesser extent in PD-MCI<CN (p = .039). However, PD-NC did not differ from PD-MCI, and PD-NC did not differ from CN (p > .050). The detection potential of MBT paired cued recall for differentiating memory impairment in AD-aMCI from CN yielded an AUC of 90% (95% CI, 85-96) and an AUC of 91% (95% CI, 81->99) between AD-aMCI and PD-MCI. Associative memory and binding impairment are most pronounced in AD-aMCI in comparison to PD-MCI and controls. Overall, the MBT is an efficient tool for the differential diagnosis of memory impairment due to the two most common neurodegenerative diseases.</p>","PeriodicalId":197,"journal":{"name":"Journal of Neuropsychology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinimetrics: Towards a diagnostic neuropsychology grounded in Alzheimer's disease.","authors":"Ciro Rosario Ilardi","doi":"10.1111/jnp.70008","DOIUrl":"https://doi.org/10.1111/jnp.70008","url":null,"abstract":"<p><p>Neuropsychology's place in diagnosing dementia is still up for debate. With the advent of disease-modifying therapies, the optimisation of diagnostic pathways is increasingly urgent, particularly in the early stages of Alzheimer's disease. Yet, biomarker-driven frameworks eclipse neuropsychological testing as an ancillary tool rather than recognising it as a core component of clinical assessment. Emerging evidence indicates that relying solely on biomarkers does not provide a dependable forecast for the onset or progression of dementia. This drawback underscores how important neuropsychology is. Nonetheless, the clinical adoption of neuropsychological tests for diagnostic purposes requires a paradigm shift towards a more rigorous methodology. Despite its recognised diagnostic potential, the current neuropsychological framework is constrained by thresholds derived from normative distributions rather than Clinimetrics. Many existing tests rely on arbitrary cut-offs that do not account for disease prevalence, personological variability, or real-world cognitive performance. This oversimplified approach reduces the sensitivity of neuropsychological assessments and limits their integration into clinical practice. The development of population-specific clinimetric studies that establish weighted cut-offs for sensitivity and specificity based on clinical aims is crucial to ensure clinically meaningful decision-making.</p>","PeriodicalId":197,"journal":{"name":"Journal of Neuropsychology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michele Scandola, Maria Esposito, Riccardo Guidotti, Daniele Romano
{"title":"How artificial intelligence is shaping neuropsychology: A focus on cognitive assessment of neurodegenerative disorders.","authors":"Michele Scandola, Maria Esposito, Riccardo Guidotti, Daniele Romano","doi":"10.1111/jnp.70009","DOIUrl":"https://doi.org/10.1111/jnp.70009","url":null,"abstract":"<p><p>Artificial intelligence (AI) and machine learning (ML) algorithms are revolutionising the world, and they have the potential to revolutionise neuropsychology as well. A particularly fruitful field for this revolution is the cognitive assessment of neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, Mild Cognitive Impairment and Primary Progressive Aphasia. This narrative review explores the impact of ML and AI in classifying these patients by using biomarkers or neuropsychological tests, using vast amounts of data and providing previously unattainable insights. Additionally, the article will evaluate the accuracies of several ML algorithms, such as support vector machines, random forest or convolutional neural networks. The article will also discuss the challenges related to ML like the risk of overfitting and the need for ML algorithms to execute a differential analysis among several pathologies-a capability that current research has yet to achieve fully. Furthermore, it proposes new directions to improve the clinical utility and accuracy of ML classification algorithms in neuropsychology, underlining the possibility for theoretical advancements based on the results of these classifications.</p>","PeriodicalId":197,"journal":{"name":"Journal of Neuropsychology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karen F Meeske, Moniek S E van Hout, Anneke Smeets, Job van der Palen, Lucille Dorresteijn, Wilma Smith-Spijkerboer, Hanneke Droste, Jacoba M Spikman
{"title":"Recovery of visual emotion recognition after mild ischemic stroke.","authors":"Karen F Meeske, Moniek S E van Hout, Anneke Smeets, Job van der Palen, Lucille Dorresteijn, Wilma Smith-Spijkerboer, Hanneke Droste, Jacoba M Spikman","doi":"10.1111/jnp.70007","DOIUrl":"https://doi.org/10.1111/jnp.70007","url":null,"abstract":"<p><p>We investigated the course of recovery of emotion recognition impairments during the first year after mild stroke. Furthermore, we studied whether long-term emotion recognition impairments are related to behavioural problems and mood problems. Patient recruitment took place at the stroke unit of a general hospital. Fifty-eight mild ischaemic stroke patients underwent neuropsychological assessments of emotion recognition and overall cognition at 6-8 weeks and 1-year post-stroke. At follow-up, questionnaires were administered to identify behavioural problems and mood problems. Emotion recognition scores of patients were compared to scores of 109 healthy controls that were matched according to age, sex and educational level to identify impairments. Baseline patient emotion recognition scores were compared to the patient scores at follow-up to investigate recovery. In this group of mild stroke patients, emotion recognition was impaired compared with healthy controls, with no recovery over time. One year after stroke emotion recognition was impaired in 31% of the mild stroke participants. At 1-year post-stroke, impaired emotion recognition was associated with overall cognitive impairment and self-reported behavioural problems, but not with mood. Even in mild stroke, emotion recognition is on average impaired in the long term and related to behavioural problems. A substantial portion of mild stroke patients have impairments in emotion recognition both in the subacute phase as well as in the long term. Early assessment of emotion recognition is important to identify patients at risk of developing behavioural problems. Appropriate and early treatment might be necessary to prevent persisting problems.</p>","PeriodicalId":197,"journal":{"name":"Journal of Neuropsychology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Self-concept and depressive symptoms three years after stroke: An evaluation of predictive value, the role of subdomains and individual importance.","authors":"Simon Ladwig, Katja Werheid","doi":"10.1111/jnp.70005","DOIUrl":"https://doi.org/10.1111/jnp.70005","url":null,"abstract":"<p><p>Depressive symptoms (DS) after stroke are associated with marked negative consequences for rehabilitation. Identifying determinants of DS is needed to enable prediction and develop psychological interventions. A promising candidate may be self-concept and changes thereof, so-called self-discrepancy. Consulting recent self-concept models, we investigated the role of self-concept subdomains and their individual importance. Within a prospective longitudinal study, 120 stroke survivors were interviewed via telephone 3 years post-ictus to assess present and past self-concept, self-discrepancy, self-concept subdomains and DS. The association of self-concept measures and DS was investigated using an ANCOVA. Controlling for established determinants (age, sex, history of depression, functional independence, social support), multiple regression analyses were used to examine the independent influence of self-concept measures and the role of subdomains and importance-weightings. Self-discrepancy showed a significant interaction with DS (F (1, 118) = 32.69, p < .001, η<sup>2</sup> = .22). DS showed a stronger association with present (r = -.72) than with past self-concept (r = -.34) and self-discrepancy (r = -.47; all p < .001). Age, history of depression, social support and present self-concept were independent predictors of DS while functional independence was not (∆F (1, 113) = 48.04, p < .001). Importance-weighting of subdomains did not affect explained variance, though the number of self-concept subdomains showing significant association with DS increased. Findings propose appraisals of self-concept as independent predictors of DS after stroke. Considering individual importance of subdomains reveals their differential influence. The results suggest investigating the use of general self-concept for prediction and considering the individual relevance of subdomains in psychological interventions after stroke.</p>","PeriodicalId":197,"journal":{"name":"Journal of Neuropsychology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Akrivi Vatsi, George Stranjalis, Stylianos Gkatzonis, Christos Koutsarnakis, Eleftherios Neromyliotis, Aristotelis Kalyvas, Ion N Beratis, Evangelos Drosos, Spyridon Komaitis, Evangelia Liouta
{"title":"Exploring Theory of Mind abilities in patients with probable idiopathic normal pressure hydrocephalus.","authors":"Akrivi Vatsi, George Stranjalis, Stylianos Gkatzonis, Christos Koutsarnakis, Eleftherios Neromyliotis, Aristotelis Kalyvas, Ion N Beratis, Evangelos Drosos, Spyridon Komaitis, Evangelia Liouta","doi":"10.1111/jnp.70003","DOIUrl":"https://doi.org/10.1111/jnp.70003","url":null,"abstract":"<p><p>This study investigated Theory of Mind (ToM) deficits in patients with suspected idiopathic normal pressure hydrocephalus (iNPH), a condition affecting motor, cognitive and autonomic functions. Given the overlap between ToM-related neural networks and those affected in iNPH, we examined whether ToM impairments are a feature of the disease. Thirty-eight patients with possible/probable iNPH and 25 healthy controls completed the Reading the Mind in the Eyes Test (RMET) along with typically administered neuropsychological tests in this population. Group differences were analysed while controlling for age and education. Pre- and post-lumbar puncture (LP) cognitive changes were also examined, and regression analyses explored cognitive and disease-specific predictors of ToM performance. Compared to the controls, patients performed significantly worse on all cognitive tests (p > .005), including the RMET [F(1, 59) = 7.209, p < .012, partial η<sup>2</sup> = .102, 95% CI [0.009, 0.278])]. Evans Index and education were significant predictors of ToM performance (p =.005). Post-LP, while a subset of patients improved in gait and verbal fluency, their ToM scores remained unchanged. ToM deficits are part of the cognitive profile of iNPH. The association between ventricular enlargement and ToM impairment necessitates further research into the neural mechanisms underlying social cognitive dysfunction in iNPH. Incorporating ToM measures in neuropsychological evaluations may aid early identification of patients with social cognitive deficits and facilitate targeted interventions.</p>","PeriodicalId":197,"journal":{"name":"Journal of Neuropsychology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144635813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Adult lifespan normative data (18-92 years) for executive function tests; the Stroop colour word test, COWAT and Hayling sentence completion test.","authors":"Patrick Murphy, Emily Webster, Lisa Cipolotti","doi":"10.1111/jnp.70001","DOIUrl":"https://doi.org/10.1111/jnp.70001","url":null,"abstract":"<p><p>The neuropsychological assessment of executive functions is an important part of the diagnostic process for many neurological diseases and for predicting the ability of neurological patients to function independently. Unfortunately, for the majority of commonly used executive function tests there is a paucity of updated normative data, particularly for older adults. This complicates the process of a clinically meaningful assessment. To help address this, we provide normative data for three well-validated tests of executive functions, the Stroop Colour/Word Test, the Controlled Oral Word Association Test and the Hayling Sentence Completion Test, alongside scores from an estimate of general intellectual ability. These tests are sensitive to frontal lobe damage and provide clinicians with information about possible focal damage to the left and right frontal lobes. Percentiles are presented for five age cohorts across the adult lifespan (18-92 years). A regression equation with age and predicted full-scale IQ also allows for the categorisation of normal and defective performance on the Stroop and Hayling tests. Given the increasing proportion of older adults requiring neuropsychological assessment, we investigated separately two groups in the older adult range: 65-79 years and 80-92 years. We found a decline in performance for older adults on all three tests. This decline was more marked amongst lower scoring older adults. We did not find a significant relationship between sex and performance on any of the three tests. The findings are discussed in the light of the cognitive reserve theory of ageing.</p>","PeriodicalId":197,"journal":{"name":"Journal of Neuropsychology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annapoorna Kuppuswamy, Anthony Harris, William De Doncker, Adrian Alexander, Nilli Lavie
{"title":"Increased neural responsiveness to distractors irrespective of perceptual load explains attention deficit in post-stroke fatigue.","authors":"Annapoorna Kuppuswamy, Anthony Harris, William De Doncker, Adrian Alexander, Nilli Lavie","doi":"10.1111/jnp.70002","DOIUrl":"https://doi.org/10.1111/jnp.70002","url":null,"abstract":"<p><p>Post-stroke fatigue (PSF) is a prevalent symptom associated with attention deficits. However, it is currently unclear what drives these. Here we applied Load Theory of Attention to investigate the role of perceptual load in the relationship between attention, distraction and fatigue levels in PSF. Thirty-two chronic stroke survivors performed a selective attention task of either low, medium or high perceptual load (varied through the number of relevant target features and their combinations). Neural responses to targets and distractor checkerboard flicker (vs. no flicker) were measured with frequency-tagged EEG responses. The results showed that fatigue severity scores were predictive of response slowing, and that this slowing was increased with higher levels of perceptual load. Fatigue severity was also associated with increased neural responsiveness to distractors, specifically: EEG 10 Hz (distractor flickering frequency) power was greater in the presence (vs. absence) of distractor flicker for participants with high (vs. low) fatigue-symptoms scores, across all levels of perceptual load in the later time period of each task trial. Overall, these results clarify the exacerbating effects of perceptual load on fatigue-related slowing, stressing the importance of cognitive, as opposed to purely motoric, deficits. Importantly, they demonstrate that increased fatigue severity involves reduced ability to suppress neural responses to irrelevant distractors, irrespective of perceptual load on attention. An account for attention in PSF based on a specific deficit in distractor suppression that is found irrespective of task demands can explain a myriad of PSF symptoms (e.g. sensory perceptual overload, difficulties to concentrate).</p>","PeriodicalId":197,"journal":{"name":"Journal of Neuropsychology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}