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Combat poison with "poison": Leader-targeted negative team gossip mitigates the detrimental team consequences of abusive supervision climate. 用“毒药”来对抗毒药:针对领导者的负面团队八卦可以减轻滥用监督氛围对团队的不利影响。
IF 6.1 1区 心理学
Journal of Applied Psychology Pub Date : 2025-09-01 Epub Date: 2025-02-27 DOI: 10.1037/apl0001268
Rui Zhong, Lingtao Yu, Jinlong Zhu, Li Zhu
{"title":"Combat poison with \"poison\": Leader-targeted negative team gossip mitigates the detrimental team consequences of abusive supervision climate.","authors":"Rui Zhong, Lingtao Yu, Jinlong Zhu, Li Zhu","doi":"10.1037/apl0001268","DOIUrl":"10.1037/apl0001268","url":null,"abstract":"<p><p>Existing research presents mixed perspectives on the impact of abusive supervision climate on team processes and effectiveness. This discrepancy prompts an important question: when, why, and how does abusive supervision climate become more or less detrimental to teams? By integrating the social functional perspective of gossip with recent theoretical advancements on abusive supervision climate, we develop a novel theoretical model to explain how leader-targeted negative team gossip-defined as the extent to which team members share negative evaluations of the leader's behaviors with each other when the leader is absent-can mitigate the adverse effects of abusive supervision climate on teams. Our model posits that leader-targeted negative team gossip serves its social function in two key ways: (a) It diminishes team members' perception of the leader as a role model, thereby reducing the influence of abusive supervision climate on team aggressive behavior, and (b) it fosters perceived similarity among team members regarding their negative attitudes toward the leader, which lessens the impact of abusive supervision climate on team affective trust. We further argue that these buffering effects of leader-targeted negative team gossip have significant downstream implications for team effectiveness, specifically in terms of team performance and team voluntary turnover. Our model was tested using two multiwave, multisource field studies employing a round-robin design, with samples of 111 and 237 work teams, respectively. The results largely supported our model. We conclude by discussing the theoretical and practical implications of our findings. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":15135,"journal":{"name":"Journal of Applied Psychology","volume":" ","pages":"1174-1197"},"PeriodicalIF":6.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
'Building our own house' as an insider-only Community-Partnered Participatory Research Council: Co-creating a safe space for Autistic knowledge production. 建立我们自己的房子",作为一个仅限内部人员参与的社区合作参与式研究理事会:共同创建自闭症知识生产的安全空间。
IF 5.6 2区 心理学
Autism Pub Date : 2025-09-01 Epub Date: 2024-05-17 DOI: 10.1177/13623613241253014
Gemma L Williams, Rebecca Ellis, Willow Holloway, Selena Caemawr, Monique Craine, Kathryn Williams, Aimee Grant
{"title":"'Building our own house' as an insider-only Community-Partnered Participatory Research Council: Co-creating a safe space for Autistic knowledge production.","authors":"Gemma L Williams, Rebecca Ellis, Willow Holloway, Selena Caemawr, Monique Craine, Kathryn Williams, Aimee Grant","doi":"10.1177/13623613241253014","DOIUrl":"10.1177/13623613241253014","url":null,"abstract":"<p><p>This article describes and reflects on the first six meetings of a newly established Autistic community council, founded to steer a participatory, longitudinal qualitative study investigating the reproductive health of Autistic people with wombs. The two key aims of these initial six meetings - involving four Autistic community leader members and three Autistic researchers - was to (1) guide the start of the project and the development of accessible recruitment materials for the future eight lay members and (2) establish a safe space and a model of accessible communication. We draw on extracts from transcripts made during meetings, member 'field' notes and a reflexive co-writing practice to identify the ways in which a sense of safety was built during these first community council meetings. We explore what it means to be an <i>insider-</i>only Community Partnered Participatory Research Council and reflect on the praxis we developed to facilitate Autistic knowledge production.Lay AbstractIn recent years, there has been a growing call for <i>participatory Autism research</i> (i.e. research that meaningfully involves Autistic people in its design and delivery). <i>Community Partnered Participatory Research</i> is a research methodology that aims to share power between researchers and members of the researched community. There is some precedent for Community Partnered Participatory Research in Autism research, but it is still quite uncommon. At the start of our new research study (called Autism: From Menstruation to Menopause), we created a community council. For the first six meetings, our council was made up of four Autistic community members who were experienced in Autism advocacy and activism and three Autistic researchers. We seven are the authors of this article. In these first six meetings, we made plans for recruiting a larger number of lay community members who would join us later for the rest of the project (8 years in total). In this article, we describe and reflect what it felt like during these first six meetings to be part of a community research council where everybody is Autistic. We discuss how we co-created a safe space, how we helped each other feel valued and how we worked together to support each other's sometimes-differing access needs so that everyone could fully participate. We provide recommendations for how to support Autistic people to lead research on their own terms with their unique insights.</p>","PeriodicalId":8724,"journal":{"name":"Autism","volume":" ","pages":"2205-2215"},"PeriodicalIF":5.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12332215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140955408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effortful control is associated with ethnic minority children's pro-wealth biases and explanations across social domains. 努力控制与少数民族儿童的亲富偏差和跨社会领域的解释有关。
IF 3.1 2区 心理学
Developmental Psychology Pub Date : 2025-09-01 Epub Date: 2024-10-31 DOI: 10.1037/dev0001853
Michelle M Wang, Tracy R Gleason, Stephen H Chen
{"title":"Effortful control is associated with ethnic minority children's pro-wealth biases and explanations across social domains.","authors":"Michelle M Wang, Tracy R Gleason, Stephen H Chen","doi":"10.1037/dev0001853","DOIUrl":"10.1037/dev0001853","url":null,"abstract":"<p><p>Children's tendency to prefer rich to poor people and to view wealthy individuals more positively has been well-documented, but little is known about (a) the mechanisms underlying this \"pro-wealth\" bias and (b) the extent to which it holds across various social domains (e.g., friendships vs. school project partners). Using a mixed-methods approach, we examined the development of status-based social preferences in a socioeconomically diverse sample of children from Chinese American immigrant families (<i>N</i> = 169; 7-11 years; <i>M</i><sub>Age</sub> = 9.16 years, <i>SD</i> ± 1.05; 87 male, 82 female). We examined the development of these preferences in middle childhood, a period during which aspects of group membership and social stratification are salient, particularly for children of immigrants. Children exhibited preferences for a high-status child over a low-status child across three social domains (friendship, playdate, and school project). Children's open-ended responses explaining their preferences most commonly referenced status-based stereotypes (e.g., \"He's more educated, he might know more about the topic\") and personal loss or gain (e.g., \"I'll get to play with his stuff\"). Children higher in parent-rated effortful control exhibited fewer status-based preferences and were less likely to reference status-based stereotypes and personal loss or gain in their explanations. Together, these findings shed light on the complexity and nuance of children's pro-wealth bias, as well as the underlying forces that drive these social preferences. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":48464,"journal":{"name":"Developmental Psychology","volume":" ","pages":"1707-1720"},"PeriodicalIF":3.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Black and Latine parent's science and math support matters: How patterns of parent support relate to adolescents' motivational beliefs and course taking across high school. 黑人和拉丁裔父母的科学和数学支持很重要:父母支持的模式如何与青少年的动机信念和整个高中的课程选择有关。
IF 3.1 2区 心理学
Developmental Psychology Pub Date : 2025-09-01 Epub Date: 2025-02-06 DOI: 10.1037/dev0001929
Christine R Starr, Nestor B Tulagan, Sandra D Simpkins
{"title":"Black and Latine parent's science and math support matters: How patterns of parent support relate to adolescents' motivational beliefs and course taking across high school.","authors":"Christine R Starr, Nestor B Tulagan, Sandra D Simpkins","doi":"10.1037/dev0001929","DOIUrl":"10.1037/dev0001929","url":null,"abstract":"<p><p>Black and Latine parents play a crucial role in shaping adolescents' math and science motivation and science, technology, engineering, and math (STEM) course taking. However, providing extensive support across various behaviors may not always be feasible nor optimal. Analyzing data from 4,230 Black and Latine families (47% Latine, 46% Black; 50% girls; 70% noncollege educated parents), we identified six distinct parent support profiles using the High School Longitudinal Study of 2009 data set. Four patterns showed higher engagement (<i>high multifaceted supporters, involved academic discussers, moderately encouraging discussers, involved STEM-encouragers</i>), and two exhibited slightly less support (<i>moderately involved academic discussers</i> and <i>moderately involved STEM nonencouragers</i>). Generally, consistent findings emerged for both Black and Latine families concerning the profiles and their relations with adolescents' math and science beliefs in 11th grade and STEM coursework. The <i>moderately encouraging discussers</i> and <i>involved STEM-encouragers</i> profiles correlated with the most positive STEM motivational beliefs and course taking, whereas the <i>moderately involved STEM nonencouragers</i> profile was associated with the lowest motivation and course taking. This suggests that STEM encouragement from parents, combined with other supportive behaviors, may be particularly crucial for Black and Latine adolescents, and high support across all indicators may not be the optimal approach, especially for high-achieving students. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":48464,"journal":{"name":"Developmental Psychology","volume":" ","pages":"1756-1777"},"PeriodicalIF":3.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differential Associations of Intrapersonal and Interpersonal Emotion Regulation with Generalized Anxiety and Social Withdrawal Among Children. 儿童内、人际情绪调节与广泛性焦虑和社交退缩的差异关联。
IF 1.7 4区 心理学
Journal of Genetic Psychology Pub Date : 2025-09-01 Epub Date: 2025-01-29 DOI: 10.1080/00221325.2025.2458493
JaNae Teer, Kyongboon Kwon, Belén López-Pérez, Marie J Enderle
{"title":"Differential Associations of Intrapersonal and Interpersonal Emotion Regulation with Generalized Anxiety and Social Withdrawal Among Children.","authors":"JaNae Teer, Kyongboon Kwon, Belén López-Pérez, Marie J Enderle","doi":"10.1080/00221325.2025.2458493","DOIUrl":"10.1080/00221325.2025.2458493","url":null,"abstract":"<p><p>Anxiety and social withdrawal are common internalizing problems among children linked to poor emotion regulation (ER). We investigated how specific components of ER (emotion awareness, emotion regulation strategy) are associated with generalized anxiety and social withdrawal in the two ER domains (intrapersonal and interpersonal). Study participants were 398 fourth- and fifth-grade students (49% girls) and 22 teachers from a Midwestern state in the United States. Study constructs were measured with student self-report, peer nominations, and teacher reports. We found anxiety was linked to poorer intrapersonal emotion awareness and greater use of adaptive and maladaptive intrapersonal regulation strategies. Social withdrawal was associated with poorer interpersonal emotion awareness and lower use of supportive and unsupportive interpersonal regulation strategies. Social withdrawal was also negatively associated with intrapersonal, adaptive strategy. The findings highlight the relevance of intrapersonal and interpersonal domains of ER in helping anxious and socially withdrawn children regarding their unique emotion regulation difficulties.</p>","PeriodicalId":54827,"journal":{"name":"Journal of Genetic Psychology","volume":" ","pages":"364-380"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fighting against self-stigma in adults with self-reported diagnosis of OCD: A single-arm pilot study using a mobile app-based intervention. 与自我报告诊断为强迫症的成年人的自我耻辱作斗争:一项使用基于移动应用程序的干预的单臂试点研究。
IF 3.1 3区 心理学
British Journal of Clinical Psychology Pub Date : 2025-09-01 Epub Date: 2025-03-10 DOI: 10.1111/bjc.12537
S Arnáez, M Roncero, J López-Santiago, G Del Valle, E Cabedo, G Bottesi, G García-Soriano
{"title":"Fighting against self-stigma in adults with self-reported diagnosis of OCD: A single-arm pilot study using a mobile app-based intervention.","authors":"S Arnáez, M Roncero, J López-Santiago, G Del Valle, E Cabedo, G Bottesi, G García-Soriano","doi":"10.1111/bjc.12537","DOIUrl":"10.1111/bjc.12537","url":null,"abstract":"<p><strong>Background: </strong>Obsessive-compulsive disorder (OCD) is a disabling disorder, and self-stigma negatively impacts quality of life, symptom severity and self-esteem. esTOCma is a smartphone-based serious game developed to increase knowledge about OCD and reduce stigma. It features 10 missions using psychoeducation, indirect contact and cognitive restructuring. Players help 10 characters escape the OCD stigma monster.</p><p><strong>Aims: </strong>To explore, in individuals with a self-reported diagnosis of OCD, the feasibility, acceptability and preliminary effectiveness of esTOCma to change self-stigma and knowledge about OCD, OC severity, guilt, quality of life and self-esteem.</p><p><strong>Materials and methods: </strong>A single-arm pilot study with 130 participants who completed esTOCma and pre-, post- and 3-month follow-up assessments.</p><p><strong>Results: </strong>Half of participants spent 9-10-days playing with the app and most of them found it useful/very useful and easy to use. Self-stigma was associated with higher OC symptoms, guilt and lower quality of life, self-esteem and knowledge about OCD. After using the app, participants showed lower levels of self-stigma, OC symptoms and guilt, and higher levels of quality of life, self-esteem and knowledge about OCD. Changes were maintained or increased at a 3-month follow-up.</p><p><strong>Discussion: </strong>esTOCma is a feasible and acceptable app that could help people with OCD to increase their knowledge and understanding of the disorder, dismiss self-stigma and OC symptoms, and at the same time increase self-esteem and quality of life. A replication of the study with a control sample is needed to validate our findings.</p><p><strong>Conclusion: </strong>Tools like the esTOCma app, accessible 24/7, offer a means to tackle self-stigma detrimental effects.</p>","PeriodicalId":48211,"journal":{"name":"British Journal of Clinical Psychology","volume":" ","pages":"788-805"},"PeriodicalIF":3.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12334988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The social model in autism research. 自闭症研究中的社会模型。
IF 5.6 2区 心理学
Autism Pub Date : 2025-09-01 Epub Date: 2025-07-12 DOI: 10.1177/13623613251357648
Hanna Bertilsdotter Rosqvist, Amy Pearson, Georgia Pavlopoulou, Kristen Bottema-Beutel
{"title":"The social model in autism research.","authors":"Hanna Bertilsdotter Rosqvist, Amy Pearson, Georgia Pavlopoulou, Kristen Bottema-Beutel","doi":"10.1177/13623613251357648","DOIUrl":"10.1177/13623613251357648","url":null,"abstract":"","PeriodicalId":8724,"journal":{"name":"Autism","volume":" ","pages":"2201-2204"},"PeriodicalIF":5.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144616108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mindful eating and food intake: Effects and mechanisms of action. 正念饮食和食物摄入:影响和作用机制。
IF 2.1 3区 心理学
Journal of Experimental Psychology-Applied Pub Date : 2025-09-01 Epub Date: 2025-03-03 DOI: 10.1037/xap0000530
Lana Seguias, Danielle Ferriday, Elanor C Hinton, Tina McCaw, Katy Tapper
{"title":"Mindful eating and food intake: Effects and mechanisms of action.","authors":"Lana Seguias, Danielle Ferriday, Elanor C Hinton, Tina McCaw, Katy Tapper","doi":"10.1037/xap0000530","DOIUrl":"10.1037/xap0000530","url":null,"abstract":"<p><p>A key component of mindful eating is paying attention to the sensory properties of one's food as one eats (\"sensory eating\"). Some studies have found this reduces subsequent food intake while others have failed to replicate these effects. We report four laboratory studies that (a) examine effects of sensory eating on subsequent intake and (b) explore potential mechanisms of action. In each study, participants ate a small high-calorie snack with or without sensory eating and, 5-15 min later, were given larger snack portions from which they could eat freely. Sensory eating reduced intake of the second snack and could not be explained by increased sensory-specific satiety or priming of health-related goals. However, this effect disappeared when we controlled eating rate for the first snack. Given evidence that slower eating increases satiation and reduces intake, we conclude that sensory eating reduces intake by slowing eating rate. Exploratory analyses also revealed that (among nondieters) effects of sensory eating were pronounced when participants reported higher hunger. Thus, for weight management, sensory eating may be most beneficial for those who are naturally fast eaters and/or in situations where people are inclined to eat more quickly, for example, when hungry or in a hurry. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":48003,"journal":{"name":"Journal of Experimental Psychology-Applied","volume":" ","pages":"168-187"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Alcea aucheri (Bioss.) Alef extract against scopolamine-induced memory impairment in rats. 赤霉素的药理作用Alef提取物对东莨菪碱致大鼠记忆损伤的保护作用。
IF 1.6 4区 心理学
Behavioural Pharmacology Pub Date : 2025-09-01 Epub Date: 2025-07-01 DOI: 10.1097/FBP.0000000000000836
Tajmah Mombeini, Hamid Gholami Pourbadie, Mohammad Kamalinejad, Ahmad Reza Dehpour, Soroush Mazloumi, Reza Hamidian
{"title":"Effect of Alcea aucheri (Bioss.) Alef extract against scopolamine-induced memory impairment in rats.","authors":"Tajmah Mombeini, Hamid Gholami Pourbadie, Mohammad Kamalinejad, Ahmad Reza Dehpour, Soroush Mazloumi, Reza Hamidian","doi":"10.1097/FBP.0000000000000836","DOIUrl":"10.1097/FBP.0000000000000836","url":null,"abstract":"<p><p>Memory impairment is a core feature of neurodegenerative diseases such as Alzheimer's disease, often modeled using scopolamine-induced cognitive dysfunction in animals. While Alcea aucheri (Boiss.) Alef has demonstrated anxiolytic properties, but its potential impact on cognitive function, particularly memory, remains unexplored. This study investigates the effects of extract of flower of Alcea aucheri (EFA) on cognitive performance in scopolamine-free rats and in a scopolamine-induced memory impairment model. Male Wistar rats were administered EFA [17.5-700 mg/kg, intraperitoneally (i.p.)] across various experimental groups. Cognitive function was assessed using the passive avoidance test for long-term memory and two-trial Y-maze for spatial reference memory. Scopolamine (2 mg/kg, i.p.) was administered to induce memory impairment. The efficacy of EFA in mitigating scopolamine-induced cognitive deficits was evaluated, and memory maintenance was assessed over 6 weeks following treatment. Except for the EFA dose of 700 mg/kg which adversly affected passive avoidance test, its other doses had no significant impact on memory performance in scopolamine-free rats, as observed in both the passive avoidance test and the two-trial Y-maze; however, in rats with scopolamine-induced cognitive deficits, EFA (particularly at 70 mg/kg) significantly improved step-through latency in the passive avoidance test ( P  < 0.001). This suggests a dose-dependent reversal of memory impairment. In addition, EFA demonstrated sustained cognitive enhancement over a 6-week period without affecting body weight. The findings suggest that EFA has a protective effect against scopolamine-induced memory impairment and could serve as a potential therapeutic agent for neurodegenerative conditions associated with cognitive decline. Further research is required to elucidate the underlying mechanisms responsible for these effects.</p>","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"387-396"},"PeriodicalIF":1.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resveratrol improves ovariectomy and chronic restraint stress-induced depression-like behaviors in mice through brain-derived neurotrophic factor associated structural synaptic remodeling. 白藜芦醇通过脑源性神经营养因子相关的结构突触重塑改善小鼠卵巢切除术和慢性约束应激诱导的抑郁样行为。
IF 1.6 4区 心理学
Behavioural Pharmacology Pub Date : 2025-09-01 Epub Date: 2025-07-31 DOI: 10.1097/FBP.0000000000000845
Hui Xu, Zhen-Qiang Zhang, Geng Chen, Ming-Jun Ge, Zong-Hao Yu, Jun-Xian Shen, Chuan Pan, Fei Han, Xiu-Ling Zhu, Ya-Ping Lu
{"title":"Resveratrol improves ovariectomy and chronic restraint stress-induced depression-like behaviors in mice through brain-derived neurotrophic factor associated structural synaptic remodeling.","authors":"Hui Xu, Zhen-Qiang Zhang, Geng Chen, Ming-Jun Ge, Zong-Hao Yu, Jun-Xian Shen, Chuan Pan, Fei Han, Xiu-Ling Zhu, Ya-Ping Lu","doi":"10.1097/FBP.0000000000000845","DOIUrl":"10.1097/FBP.0000000000000845","url":null,"abstract":"<p><p>Previous studies have shown that resveratrol has antidepressant effects in a variety of depression models, but the effect and mechanism of resveratrol on menopausal depression are unclear. In this study, transgenic mice were ovariectomized combined with chronic restraint stress to establish a model of menopausal depression. The antidepressant effect of resveratrol was evaluated by tail suspension test (TST), forced swimming test, sucrose preference test (SPT), and novel inhibition feeding test (NSFT). Using the characteristic expression of yellow fluorescent protein in excitatory neurons of transgenic mice, the effects of resveratrol on the density of dendrites and dendritic spines were evaluated by a three-dimensional imaging technique. Brain-derived neurotrophic factor (BDNF), cofilin1, and p-cofilin1 were quantitatively analyzed by quantitative PCR and immunofluorescence quantification to explore the effects of resveratrol on synaptic plasticity in the hippocampus and medial prefrontal cortex (mPFC) and its mechanism. The results revealed that resveratrol significantly decreased the immobility time in TST, shortened the feeding latency and increased the food intake in NSFT, and enhanced the sucrose consumption in SPT. Consistent with these changes, resveratrol treatment significantly increased the density of p-cofilin1 immunoreactive dendritic spines and the mRNA level of BDNF in these brain regions. The results suggest that resveratrol can improve the synaptic plasticity in the corresponding brain regions by upregulating BDNF levels, enhancing the phosphorylation of cofilin 1, increasing the density of dendrites and dendritic spines in the hippocampus and mPFC, and ultimately improving menopausal depression-like behaviors.</p>","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":" ","pages":"364-377"},"PeriodicalIF":1.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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