Nanoscale最新文献

{"title":"More than a delivery system: the evolving role of lipid-based nanoparticles","authors":"Senjuti Karmaker, Plinio D. Rosales, Barath Tirumuruhan, Amartya Viravalli, Natalie Boehnke","doi":"10.1039/d4nr04508d","DOIUrl":"https://doi.org/10.1039/d4nr04508d","url":null,"abstract":"Lipid-based nanoparticles, including liposomes and lipid nanoparticles (LNPs), make up an important class of drug delivery systems. Their modularity enables encapsulation of a wide range of therapeutic cargoes, their ease of functionalization allows for incorporation of targeting motifs and anti-fouling coatings, and their scalability facilitates rapid translation to the clinic. While the discovery and early understanding of lipid-based nanoparticles is heavily rooted in biology, formulation development has largely focused on materials properties, such as how liposome and lipid nanoparticle composition can be altered to maximize drug loading, stability and circulation. To achieve targeted delivery and enable improved accumulation of therapeutics at target tissues or disease sites, emphasis is typically placed on the use of external modifications, such as peptide, protein, and polymer motifs. However, these approaches can increase the complexity of the nanocarrier and complicate scale up. In this review, we focus on how our understanding of lipid structure and function in biological contexts can be used to design intrinsically functional and targeted nanocarriers. We highlight formulation-based strategies, such as the incorporation of bioactive lipids, that have been used to modulate liposome and lipid nanoparticle properties and improve their functionality while retaining simple nanocarrier designs. We also highlight classes of naturally occurring lipids, their functions, and how they have been incorporated into lipid-based nanoparticles. We will additionally position these approaches into the historical context of both liposome and LNP development.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"183 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Hollow Au nanoparticles for single-molecule Raman spectroscopy via a synergistic electromagnetic and chemical enhancement strategy","authors":"Zihan Gao, Haiyao Yang, Jianzhi Zhang, Jie Yang, Lihong Hong, Zhi-Yuan Li","doi":"10.1039/d5nr90063h","DOIUrl":"https://doi.org/10.1039/d5nr90063h","url":null,"abstract":"Correction for ‘Hollow Au nanoparticles for single-molecule Raman spectroscopy <em>via</em> a synergistic electromagnetic and chemical enhancement strategy’ by Zihan Gao <em>et al.</em>, <em>Nanoscale</em>, 2025, https://doi.org/10.1039/d4nr05311g.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"66 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of concern: A hysteresis-free perovskite transistor with exceptional stability through molecular cross-linking and amine-based surface passivation","authors":"Hyeong Pil Kim, Maria Vasilopoulou, Habib Ullah, Salma Bibi, Anderson Emanuel Ximim Gavim, Andreia Gerniski Macedo, Wilson Jose da Silva, Fabio Kurt Schneider, Asif Ali Tahir, Mohd Asri Mat Teridi, Peng Gao, Abd. Rashid bin Mohd Yusoff, Mohammad Khaja Nazeeruddin","doi":"10.1039/d5nr90064f","DOIUrl":"https://doi.org/10.1039/d5nr90064f","url":null,"abstract":"Expression of concern for ‘A hysteresis-free perovskite transistor with exceptional stability through molecular cross-linking and amine-based surface passivation’ by Hyeong Pil Kim <em>et al.</em>, <em>Nanoscale</em>, 2020, <strong>12</strong>, 7641–7650, https://doi.org/10.1039/C9NR10745B.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"73 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving the Washability of Conductive Textiles by Constructing a Dually Crosslinked Polyvinyl Alcohol Network with Silver Nanowires","authors":"Qianru Ge, Qingyang Zeng, Shuxin Li, Shulin Ji","doi":"10.1039/d5nr01022e","DOIUrl":"https://doi.org/10.1039/d5nr01022e","url":null,"abstract":"Conductive textiles as an important platform for developing wearable electronic devices, often face washing problems to remove dirt while keep conductive. It is still a great challenge to manufacture textiles with high conductivity, washability and uniformity in an efficient and economical way. Polyvinyl alcohol (PVA) containing numerous hydroxyl groups for easy modification and crosslinking, is a promising candidate for conductive textile construction. Herein, a stable composite ink with PVA as the matrix and silver nanowires (AgNWs) as the conductive filler for screen printing on textile surface is proposed. The composite conductive network endows the fabric with a highest conductivity up to 2087 S cm-1 and a low percolation threshold of 0.025 mg cm-2 for AgNW mass loading. The printed conductive pattern shows a high uniformity even for a line width as small as 500 μm on fabric. The resistance change of conductive textiles washed at 60 °C for 1 h is reduced from 500000% to 40%, thanks to the cooperation of a physically and chemically dually-crosslinked polymer network with a conductive AgNW network. The prepared outperforming conductive textiles as well as the potential for mass production of patterned fabric electrodes, provide a basis for further development of smart fabrics and wearable electronics.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"38 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strain and doping transfer between suspended and supported bilayer graphene","authors":"Riccardo Galafassi, Fabien VIALLA, Vincent Rajaji, Alexis Forestier, Bruno Sousa Araújo, Hatem Diaf, Natalia Del Fatti, Antonio Gomes Souza Filho, Arnaud Claudel, Laetitia Marty, Alfonso San-Miguel","doi":"10.1039/d4nr05331a","DOIUrl":"https://doi.org/10.1039/d4nr05331a","url":null,"abstract":"Due to their unique dimensionality, the physical properties of two dimensional materials are deeply impacted by their surroundings, calling for a thorough understanding and control of these effects. We investigated the influence of the substrate and the pres- sure transmitting medium on bilayer graphene in a unique high pressure environment where the sample is partially suspended and partially supported. By employing Raman spectroscopy with a sub-micron spatial resolution, we explored the evolution of strain and doping, and demonstrated that they are both similarly induced in the suspended and supported regions of the bilayer graphene within the studied pressure range. Almost full strain and doping transfer between the supported and suspended regions is concluded. We observed that charge carrier density saturates quickly at low pressures (2 GPa) while biaxial strain continuously increases with pressure. Additionally, Raman spatial mapping highlights a rather uniform doping and strain distribution, yet with significant local variations revealing a more complex scenario than previously documented by single-point studies at high pressure.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"183 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectroscopic evidence of intra-unit-cell charge redistribution in a charge-neutral magnetic topological insulator","authors":"Khanh Duy Nguyen, Gabriele Berruto, Seng Huat Lee, Yunhe Bai, Haoran Lin, Qiang Gao, Zhiqiang Mao, Shuolong Yang","doi":"10.1039/d4nr04812a","DOIUrl":"https://doi.org/10.1039/d4nr04812a","url":null,"abstract":"The magnetic topological insulator MnBi<small>₆</small>Te<small>₁₀</small> has emerged as a promising candidate for realizing the quantum anomalous Hall effect (QAHE), owing to its ability to retain ferromagnetism through precise control of anti-site defects. The next important task for realizing the QAHE is to tune the chemical potential into the energy gap formed by the broken time-reversal symmetry. Here we reveal an intra-unit-cell charge redistribution even when the overall doping suggests a near-charge-neutral condition. By performing time- and angle-resolved photoemission spectroscopy (trARPES) on the optimally 18% Sb-doped MnBi<small>₆</small>Te<small>₁₀</small>, we observe transient surface photovoltage (SPV) effects on both the MnBi<small>₂</small>Te<small>₄</small> and single-Bi<small>₂</small>Te<small>₃</small> terminations. Furthermore, we observe a time-dependent splitting of the band structure indicating multiple SPV shifts with different magnitudes. This observation suggests that adjacent plateaus with nominally the same terminating layer exhibit a strong intra-unit-cell charge redistribution, resulting in spontaneous electrical polarization. This is consistent with static micro-ARPES measurements revealing significant doping deviations from the charge-neutral configuration. Our findings underscore the challenges of engineering the family of Mn-Bi-Te materials to realize QAHE purely through chemical doping. Achieving the desired topological quantum phase requires both a uniform carrier doping and a ferromagnetic ground state. Furthermore, the light-induced polarization within each unit cell of ferromagnetic Mn(Bi<small>_0.82</small>Sb<small>_0.18</small>)<small>₆</small>Te<small>₁₀</small> may open new possibilities for optoelectronic and spintronics.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"38 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catalytic and Biological Properties of Ag-Pt Bimetallic Nanoparticles: Composition-Dependent Activity and Cytotoxicity","authors":"Rongtao Liu, Hongwei Liang, Jian Liu, Huoqing Zhong, Rongxue Cui, Xin Li, Bing Yan, Hongyu Zhou","doi":"10.1039/d5nr00713e","DOIUrl":"https://doi.org/10.1039/d5nr00713e","url":null,"abstract":"Due to their unique elemental compositions and interface coupling effects, bimetallic nanoparticles (BNPs), a class of nanoalloys, have attracted significant attention for applications in biomedicine, environmental remediation, and catalysis. BNPs, formed via the combination of two metal ions under light or thermal conditions, exhibit enhanced catalytic properties due to synergistic interactions between constituent metals, which result in optimized electronic structures, increased active sites, and reduced activation energy for catalytic reactions. However, BNPs may pose potential toxicity risks to organisms through bioaccumulation and environmental exposure. In this study, Ag-Pt nanoparticles (AP NPs) with varying molar ratios were synthesized and characterized to elucidate the relationship between composition, catalytic activity, and cytotoxicity. Catalytic assays revealed that AP NPs exhibited remarkable oxidase-like activity. Cytotoxicity tests revealed dose- and composition-dependent effects, with the AP55 (Ag:Pt at 5:5 ratio) exhibiting the highest cytotoxicity compared to monometallic counterparts at equivalent concentrations. Notably, the proportion of Ag in the AP NPs was identified as the dominant factor influencing catalytic activity and cytotoxicity. Mechanistic investigations attributed this cytotoxicity to the interplay of peroxidase-like catalytic activity, oxidative stress, and lysosomal ion release, disrupting cellular redox homeostasis and triggering apoptosis. Enzymatic assays further confirmed reductions in antioxidant defenses, including superoxide dismutase (SOD) and catalase (CAT) activities, amplifying reactive oxygen species (ROS) generation and oxidative damage. These findings underscore the critical role of catalytic behavior in mediating biological interactions and cytotoxic effects of BNPs. We establish a relationship between composition, oxidase-like activity, and cytotoxicity, providing insights into their potential biomedical applications and paving the way for the rational design of multifunctional nanomaterials with tunable biological effects.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"22 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing transistor-based point-of-care (POC) biosensors: additive manufacturing technologies and device integration strategies for real-life sensing.","authors":"Xiaoao Shi, Haihui Pu, Lewis L Shi, Tong-Chuan He, Junhong Chen","doi":"10.1039/d4nr04441j","DOIUrl":"https://doi.org/10.1039/d4nr04441j","url":null,"abstract":"<p><p>Infectious pathogens pose a significant threat to public health and healthcare systems, making the development of a point-of-care (POC) detection platform for their early identification a key focus in recent decades. Among the numerous biosensors developed over the years, transistor-based biosensors, particularly those incorporating nanomaterials, have emerged as promising candidates for POC detection, given their unique electronic characteristics, compact size, broad dynamic range, and real-time biological detection capabilities with limits of detection (LODs) down to zeptomolar levels. However, the translation of laboratory-based biosensors into practical applications faces two primary challenges: the cost-effective and scalable fabrication of high-quality transistor sensors and functional device integration. This review is structured into two main parts. The first part examines recent advancements in additive manufacturing technologies-namely in screen printing, inkjet printing, aerosol jet printing, and digital light processing-and evaluates their applications in the mass production of transistor-based biosensors. While additive manufacturing offers significant advantages, such as high quality, cost-effectiveness, rapid prototyping, less instrument reliance, less material waste, and adaptability to diverse surfaces, challenges related to uniformity and yield remain to be addressed before these technologies can be widely adopted for large-scale production. The second part focuses on various functional integration strategies to enhance the practical applicability of these biosensors, which is essential for their successful translation from laboratory research to commercialization. Specifically, it provides a comprehensive review of current miniaturized lab-on-a-chip systems, microfluidic manipulation, simultaneous sampling and detection, wearable implementation, and integration with the Internet of Things (IoT).</p>","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An injectable hydrogel with photothermal and chemodynamic therapies for targeted promotion of ferroptosis in oral squamous cell carcinoma","authors":"Xu Zhang, Mao Li, Xin Pang, Wan-Li Wang, Xiao-Chen Wang, Ze-Liang Shen, Rong-Jia Shi, Ya-Ling Tang, Xin-Hua Liang","doi":"10.1039/d4nr05147e","DOIUrl":"https://doi.org/10.1039/d4nr05147e","url":null,"abstract":"Ferroptosis-driven tumor ablation strategies based on nanotechnology could be achieved by increasing hydrogen peroxide (H<small>₂</small>O<small>₂</small>) concentrations or decreasing glutathione (GSH) levels. However, the intracellular antioxidative defense mechanisms endow the oral squamous cell carcinoma (OSCC) cells with ferroptosis resistance capacity. Therefore, injectable self-healing carboxymethyl chitosan (CMCS)/aldehyde-based hyaluronic acid (HA–CHO)/PVP–CuO<small>₂</small> (PCu)/polydopamine (PDA) (CHPP) hydrogels were developed to promote ferroptosis through increasing H<small>₂</small>O<small>₂</small> concentrations and decreasing GSH levels. The introduction of HA–CHO can directly target the CD44 receptor and form Schiff bonds <em>via</em> CMCS to build the backbone of CHPP hydrogels. The CHPP hydrogels can responsively release H<small>₂</small>O<small>₂</small> to catalyze the production of hydroxyl radical (˙OH) <em>via</em> chemodynamic therapy (CDT) in the tumor microenvironment (TME), sustained depletion of GSH through the dual action of Cu<small>²⁺</small> and ˙OH, and generate repeated high temperatures under photothermal therapy (PTT) for a direct OSCC-killing effect after the loading of PCu and PDA. In addition, the OSCC tissue RNA sequencing suggests that the differentially expressed genes of the CHPP hydrogels exerting the targeted OSCC therapy enrich the ferroptosis signaling pathways significantly. Then, liproxstatin-1 (a ferroptosis inhibitor) was utilized to recover the activation of glutathione peroxidase 4 (GPX4), which can weaken the therapeutic effect of CHPP on OSCC. The CHPP hydrogels are a promising strategy for the treatment of OSCC.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"32 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced Graphene Oxide/ZnO Nanocomposites: One-Step Solid State Preparation for Room Temperature Photo-sensing and Photoelectrical Gas Sensing Capabilities","authors":"Nileshkumar M. Pardeshi, Rahul S. Ghuge, Priyanka N. Birla, Mohan Nagarajan, Manish D. Shinde, Yuvaraj Sivalingam, Rajendra Devidas Kale, Sunit Rane","doi":"10.1039/d4nr04345f","DOIUrl":"https://doi.org/10.1039/d4nr04345f","url":null,"abstract":"Detecting triethylamine (TEA), a highly active industrial chemical, is crucial in today's globalized world with increasing air pollution. In this work, we proposed reduced graphene oxide (rGO)/ZnO nanocomposites for efficient TEA detection under ultraviolet (UV) light activation at room temperature. rGO@ZnO nanocomposites with varying rGO weight percentages (1, 2.5, 5, and 10 wt%) were synthesized through a scalable, one-step solid-state method, and were characterized using various physicochemical techniques. Among the samples, the 2.5% rGO@ZnO nanocomposite exhibited the highest photo response after UV light shining, indicating superior carrier concentration generation under UV light. TEA sensing studies were carried out under UV light using sensors based on pristine ZnO nanopowder and the 2.5% rGO@ZnO composite. The 2.5% rGO/ZnO sensor demonstrated a significantly enhanced TEA sensing response (35%) than the pristine ZnO along with a lower detection limit of 15.6 ppm at room temperature. The sensing mechanism was explained using the depletion layer model, supplemented by scanning Kelvin probe analysis, which highlighted the role of UV light activation in improving sensor performance. These findings underscore the potential of UV-activated rGO/ZnO nanocomposite sensors for sensitive and efficient TEA detection.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"18 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}