Nanoscale最新文献

{"title":"Chiral Induction in BiPO₄ Nanorods by Amino Acids","authors":"Lama Jabareena,Prasenjit Das,Ilya Grinberg,Yitzhak Mastai","doi":"10.1039/d6nr03503e","DOIUrl":"https://doi.org/10.1039/d6nr03503e","url":null,"abstract":"We report the amino-acid-directed crystallization of chiral bismuth phosphate (BiPO₄, ximengite) nanorods under mild aqueous conditions at room temperature. Enantiopure L- and D-aspartic acid were employed as molecular inducers, producing BiPO₄ nanorods with opposite chiroptical responses and controlled morphology. X-ray diffraction and high-resolution transmission electron microscopy confirmed the formation of the trigonal BiPO₄ phase, while circular dichroism measurements revealed mirror-image optical activity for the L- and D-induced materials. The resulting nanorods exhibited pronounced enantioselective molecular recognition, as investigated by isothermal titration calorimetry, circular dichroism adsorption experiments, and chiral high-performance liquid chromatography. Distinct thermodynamic responses were observed for matched and mismatched crystal–amino acid combinations, demonstrating stereoselective interactions at the crystal–solution interface. Notably, selective adsorption from racemic alanine solutions produced an enantiomeric excess of up to 46% in the remaining solution. These findings highlight amino-acid-mediated crystallization as a promising approach to preparing chiroptically active inorganic nanomaterials and demonstrate the potential of BiPO₄ nanorods for enantioselective adsorption and chiral separation.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"12 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149360462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prochiral nanocrystals.","authors":"David Avnir","doi":"10.1039/d6nr03232j","DOIUrl":"https://doi.org/10.1039/d6nr03232j","url":null,"abstract":"<p><p>Chiral nanocrystals have received intensive attention, leading to development of their synthetic routes and a host of applications, ranging from optics to catalysis. It seems that the prochirality of nanocrystals is a structural feature that has not received any attention so far. Prochirality in that context is a shape property by which two faces of the achiral nanocrystal - the enantiotopic faces - are enantiomorphic 2D-chiral polygons. The main feature of prochirality is that it allows conversion into chiral objects in a single step. The prochirality of crystals is particularly relevant for the nanoscale, due to the dominance of the high surface-to-volume ratio in the activity of these nanomaterials, due to the well-developed ligand/adsorbate toolkit for controlling the shape, and due to the ability to obtain a large population of crystals with practically the same habit. We provide a detailed explanation of prochirality in the context of crystals, and describe literature examples that report nanocrystal shapes that are prochiral (not recognizing that this is the case). Since achiral habits are found not only in crystals molecularly characterized by the improper-element space group symmetries but also in crystals that adopt the 65 Sohncke space groups, the interplay between the 2D-molecular level chirality of enantiotopic faces and their 2D-shape chirality is discussed as well. Finally, we propose a variety of potential applications of prochiral nanocrystals, including their use as building blocks for chiral nano-metamaterials and metasurfaces.</p>","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149339939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward a strategy against isotonitazene intoxication through supramolecular sequestration of the parent opioid and its active metabolites.","authors":"Desmond MacLeod-Carey, Carolina Olea-Ulloa","doi":"10.1039/d6nr03226e","DOIUrl":"https://doi.org/10.1039/d6nr03226e","url":null,"abstract":"<p><p>The recent emergence of nitazenes, a highly potent class of synthetic opioids derived from 2-benzylbenzimidazole, represents a public health crisis due to their high risk of overdose and renarcotization. Conventional antagonists, such as naloxone, face limitations associated with their competitive mechanism of action and short duration, highlighting the need for alternative strategies to address isotonitazene intoxication. We propose a supramolecular sequestration strategy to reduce the free fraction of isotonitazene (ITZ) and its active hepatic metabolites in aqueous media. The tetraanionic cyclophane ACyp is employed as a synthetic receptor for ITZ and its <i>N</i>-deethylated (ND-ITZ), <i>O</i>-dealkylated (OD-ITZ), and <i>N</i>-deethylated/<i>O</i>-dealkylated (ND-OD-ITZ) metabolites. xTB molecular dynamics simulations show the formation of 1 : 1 intracavitary supramolecular inclusion complexes, while density functional theory (DFT) calculations at the PBE-D3(BJ)/TZ2P level, combined with thermochemical corrections, suggest spontaneous and exergonic association. Comparison with free ACyp reveals guest-dependent conformational adaptation, consistent with an induced-fit contribution to recognition. Classical molecular dynamics simulations of 100 ns in explicit water show that inclusion persists during macrocycle rearrangements and reorganization of the host-guest contacts. Energy decomposition analysis (EDA) reveals that in all studied systems, the interaction energy is predominantly governed by electrostatic contributions, primarily due to ammonium-carboxylate interactions. The Independent Gradient Model-Noncovalent Interaction analysis (IGM-NCI), together with electron density difference maps (Δ<i>ρ</i>), reveals the complexation modes of the supramolecular systems. These analyses show localized electronic polarization in the ammonium-carboxylate interaction region; additionally, van der Waals dispersive interactions between the macrocycle's aromatic cavity and the opioids' benzimidazole cores are observed. Finally, this computational evidence supports the recognition and potential sequestration of ITZ and its active hepatic metabolites through a combination of ammonium-carboxylate contacts and structural adaptability of ACyp, establishing a molecular basis for a supramolecular strategy aimed at reducing their free fraction and supporting future interventions against isotonitazene intoxication.</p>","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149339940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metasurface-Driven Polarization-Sensitive Photodetectors in Black Phosphorus via Quasi-BIC Engineering","authors":"Xiao Liu,Tianxiang Zhao,Ting Wang,Junsheng Xu,Junyong Wang,Kai Zhang,Hongliang Li,Junjia Wang,Xuechao Yu","doi":"10.1039/d6nr02966c","DOIUrl":"https://doi.org/10.1039/d6nr02966c","url":null,"abstract":"High-performance infrared photodetection is essential for various applications, including surveillance, environmental monitoring, optical communication, and biomedical imaging. However, conventional bulk detectors remain limited by poor spectral tunability, mechanical rigidity, and high dark currents, motivating the pursuit of low-dimensional material platforms, such as graphene and transition metal dichalcogenides. Black phosphorus (BP) is particularly compelling in this context owing to its thickness-tunable direct bandgap, high carrier mobility, and pronounced in-plane anisotropy. However, the atomically thin nature inherently restricts light absorption, posing a fundamental bottleneck for device performance. Here, we demonstrate quasi-bound states in the continuum (quasi-BICs) within a dielectric metasurface integrated with BP, enabling strongly enhanced and spectrally selective light-matter interactions. By implementing controlled symmetry breaking at the unit cell level, high-quality-factor resonances are achieved, leading to significant electromagnetic field confinement within the BP layer. This resonant enhancement substantially increases the photocarrier generation while preserving the intrinsic polarization anisotropy of BP, which elucidates a robust pathway for overcoming the optical absorption bottleneck in anisotropic 2D optoelectronics via quasi-BIC platforms.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"19 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149360460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic Electride-Like States and Built-In Fields: MoSH Buffer Layers for High-Efficiency Tunneling Contacts in MoS2 Transistors","authors":"Shusheng Song,Zheng Song,Luoxin Wang,Baozeng Zhou,X. C. Wang","doi":"10.1039/d6nr03259a","DOIUrl":"https://doi.org/10.1039/d6nr03259a","url":null,"abstract":"The realization of low-resistance contacts in two-dimensional (2D) semiconductors remains a critical bottleneck for high-performance electronic devices. Here, we propose a contact architecture employing a semi-hydrogenated MoSH monolayer as a buffer layer between graphene electrodes and MoS2 channels, leveraging its unique electride-like electronic states and intrinsic built-in electric field to overcome the limitations of conventional metal and graphene contacts. Through comprehensive first-principles calculations, we demonstrate that the asymmetric hydrogenation of MoS2 induces a strong perpendicular dipole, giving rise to an exceptionally low work function on the Mo-H surface and enabling synergistic coupling with interfacial charge transfer. This synergy eliminates Fermi level pinning and establishes either n- or p-type Ohmic contacts depending on the contacting surface, with Gr/HMoS achieving a tunneling probability approaching 98% and a tunneling specific resistance approaching zero under a spacing reduction of about 1.0 Å. The tunneling dynamic contact optimization. Based on these findings, we propose a fully 2D van der Waals field-effect transistor architecture integrating graphene/MoSH contacts with a seamless MoSH-MoS2 in-plane heterojunction, enabling polarity control and efficient carrier injection. Our results establish MoSH as a transformative buffer material and reveal a general mechanism by which electride-like states and internal electric fields can synergistically resolve the contact resistance challenge in 2D electronics.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"16 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149360488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Ti-Mg co-doping and MWCNTs modification on surface structure and electrochemical performance of LMFP","authors":"Qian He,Junhao Li,Qian Luo,Xinqi Huang,Lulu Zhang,Jun Li","doi":"10.1039/d6nr02854c","DOIUrl":"https://doi.org/10.1039/d6nr02854c","url":null,"abstract":"To overcome the intrinsic limitations of olivine-type LiMn0.5Fe0.5PO4 (LMFP55) cathode materials, including poor electronic conductivity, sluggish Li⁺ diffusion kinetics, and Mn dissolution during cycling, a stepwise modification strategy combining Ti–Mg co-doping and multi-walled carbon nanotube (MWCNT) incorporation was developed to improve the electrochemical performance of LMFP cathodes. The Ti–Mg co-doping strategy regulates the local crystal structure and improves structural stability of the material, while the introduction of MWCNTs constructs an interconnected conductive network that facilitates electron transport and enhances interfacial stability. Among the investigated samples, the composite with nominal Ti and Mg stoichiometric coefficients of 0.03 and 0.02, respectively, and an MWCNT loading of 4 wt% exhibits the best overall electrochemical performance. It delivers an initial discharge capacity of 156.87 mAh g-1 and an initial Coulombic efficiency of 94.81% at 0.1 C. Furthermore, the optimized electrode exhibits a capacity decay of only 13.23% after 200 cycles and maintains a capacity retention of 74.87% after 500 cycles at 2 C. The enhanced electrochemical kinetics are further confirmed by the reduced charge-transfer resistance (27.86 Ω) and increased Li+ diffusion coefficient (7.90×10-13 cm2 s-1). These improvements are attributed to the synergistic regulation of the crystal structure and conductive framework achieved through Ti–Mg co-doping and MWCNT incorporation. This study provides insights into the structural optimization of LMFP cathode materials and offers a promising approach for developing high-performance lithium-ion batteries.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"9 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149360459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defect Engineered V2O5-SrTiO3 Heterostructure with Abundant Surface Oxygen Vacancies for Enhanced Alkaline Oxygen Evolution Catalysis","authors":"Unnati Bora,Nishita Kashyap,Palash J Thakuria,Ankur Kanti Guha,Lakshi Saikia","doi":"10.1039/d6nr03384a","DOIUrl":"https://doi.org/10.1039/d6nr03384a","url":null,"abstract":"Developing efficient electrocatalysts is crucial for addressing clean energy and environmental challenges. Electrocatalysts for water splitting offer substantial promise for sustainable energy systems and meeting global demand for renewable energy. However, high-performance catalysts for the electrochemical oxygen evolution reaction (EOER) remain a significant challenge. To achieve a highly efficient catalytic system, we have designed a hybrid electrocatalyst composed of SrTiO3 Perovskite Oxide nanoparticles and V2O5. The V2O5-SrTiO3 nanohybrid is anticipated to form a heterojunction structure enriched with surface oxygen vacancies and Ti³⁺ defect sites to effectively promote oxygen generation during water splitting in alkaline media (1M KOH). Electrochemical measurements reveal that the V2O5-SrTiO3 composite exhibits remarkable OER performance, featuring a low overpotential at 20 mAcm-2, enhanced double-layer capacitance, expanded electrochemical surface area, and enhanced specific capacity. The superior catalytic activity is primarily attributed to the synergistic interaction between SrTiO3 and V2O5, where the layered structure and redox-active nature of V2O5 play a pivotal role. This study underscores the potential of V2O5-SrTiO3 composites as robust and efficient OER electrocatalysts, offering valuable insights for the development of next-generation materials for sustainable energy conversion.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"34 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149359785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-template molecular imprinting enables fully synthetic phosphatidylserine-targeted cancer therapy.","authors":"Shuhan Hu, Wenjing Yu, Luxi Chen, Muhammad Mujahid Ali, Juntao Zhou, Lei Ye, Lianghai Hu","doi":"10.1039/d6nr02739c","DOIUrl":"10.1039/d6nr02739c","url":null,"abstract":"<p><p>Phosphatidylserine (PS) exposed on tumor cell membranes is an attractive target for cancer therapy, but current PS-targeting strategies depend largely on biologically derived ligands that suffer from calcium dependence, limited stability, immunogenicity risk, and manufacturing complexity. Here, we report a fully synthetic therapeutic platform based on dual-template molecular imprinting that integrates PS-targeted tumor recognition with pH-responsive doxorubicin (Dox) delivery in a single nanocarrier. By co-imprinting the PS polar head group and Dox, the resulting molecularly imprinted polymer nanoparticles (dt-MIP) generate orthogonal binding sites for membrane targeting and drug loading, achieving high binding capacities for PS and Dox (<i>Q</i>_max ∼ 180 mg g^-1 and ∼37 mg g^-1, respectively), high selectivity, minimal drug leakage at physiological pH, and accelerated release in acidic environments. The dt-MIP recognized surface-exposed PS with specificity comparable to Annexin V and enabled PS-dependent Dox delivery across multiple cell lines, with delivery efficiency correlating with the degree of PS externalization. In triple-negative breast cancer cells, Dox-loaded dt-MIP markedly enhanced intracellular drug accumulation and reduced cell viability to ∼8% at 200 μg mL^-1 dt-MIP, compared with ∼70% for free Dox at the same dose. In an MDA-MB-231 xenograft model, dt-MIP achieved tumor-selective accumulation and substantially suppressed tumor growth while maintaining a favorable safety profile. These results establish dual-template molecular imprinting as a general strategy for constructing fully synthetic, target-directed cancer therapeutics, positioning PS-imprinted nanocarriers as an alternative to biologically derived targeting systems.</p>","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":" ","pages":"23246-23257"},"PeriodicalIF":5.2,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conductive filament dynamics in memristive sensors: from resistive switching mechanisms to multifunctional sensing applications.","authors":"Peilun Qiu, Xuehai Li, Xintian Chen, Hanjia Liu, Yihan Cui, Chuqiao Hu, Di Wu, Jianqiao Liu, Ce Fu","doi":"10.1039/d6nr02720b","DOIUrl":"https://doi.org/10.1039/d6nr02720b","url":null,"abstract":"<p><p>With advances in sensor technology, various sensors are being widely applied, becoming an indispensable part of modern life. However, constrained by inherent sensing mechanisms, certain performance limitations remain difficult to improve through conventional modification methods. Herein, we focus on memristors for various sensing applications, summarizing how their resistive switching effect enables the modulation of device performance. First, the development history of memristors is outlined, and recent research progress in the fields of gas sensing, optoelectronic sensing, and pressure sensing is summarized. Meanwhile, representative memristors are employed as examples to investigate the role of conductive filaments in resistive switching at the molecular and atomic levels. Subsequently, the current research status of memristors in gas sensing, optoelectronic sensing, and pressure sensing is presented from three aspects: the modification mechanism of the resistive switching effect, performance characteristics, and applications. In addition, the applications of memristors in other fields are discussed, including oscillators, hardware encryption, and thermal imaging detection. Finally, the prospects and challenges of memristor-based sensors are analyzed, and potential directions for future research are proposed. This review centers on the regulation mechanisms of the resistive switching effect in various fields, offering a novel perspective for developing high-performance sensing technologies.</p>","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149331745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrinsic meron spin textures generated by an all-silicon terahertz meta-lens","authors":"Hui Li,Wangyong Ma,Hongyang Wang,Wenhui Xu,Kai Shao,Feng Qiu,Yang Ren,Jianquan Yao","doi":"10.1039/d6nr03699f","DOIUrl":"https://doi.org/10.1039/d6nr03699f","url":null,"abstract":"Optical skyrmions and merons, topologically nontrivial textures of the electromagnetic field, have opened new avenues for structured light, yet their generation has so far relied on bulky focusing optics or specially crafted microstructures. Here we demonstrate that a planar all-silicon meta-lens can directly generate an intrinsic meron spin texture in a tightly focused terahertz beam at 0.9 THz. The meta-lens consists of half-wave-plate meta-atoms that simultaneously reverse the helicity of the incident circularly polarized wave and imprint a hyperbolic focusing phase through the propagation phase, yielding an effective numerical aperture of 0.8. Full-wave simulations show that the focused field carries a meron texture whose skyrmion number reaches ∓0.4915 at the meron radius for the two incident helicities, within two percent of the ideal half-integer value predicted by vectorial diffraction theory. The texture persists at three simulated frequencies spanning a fractional range of about eleven percent and, more strikingly, for fully polarized elliptical inputs away from the exact linear-polarization transition: the skyrmion number vanishes only for exactly linearly polarized input, which forms a measure-zero transition set on the equator of the Poincaré sphere, whereas its sign is selected by the spin content of the incident wave. These results establish a compact, broadband and polarization-tolerant terahertz platform for topological spin textures, with prospects for spin-controlled light-matter interaction, particle manipulation and topological optical information processing.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"102 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149359783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}