Nanoscale最新文献

{"title":"Dual-template molecular imprinting enables fully synthetic phosphatidylserine-targeted cancer therapy.","authors":"Shuhan Hu, Wenjing Yu, Luxi Chen, Muhammad Mujahid Ali, Juntao Zhou, Lei Ye, Lianghai Hu","doi":"10.1039/d6nr02739c","DOIUrl":"https://doi.org/10.1039/d6nr02739c","url":null,"abstract":"<p><p>Phosphatidylserine (PS) exposed on tumor cell membranes is an attractive target for cancer therapy, but current PS-targeting strategies depend largely on biologically derived ligands that suffer from calcium dependence, limited stability, immunogenicity risk, and manufacturing complexity. Here, we report a fully synthetic therapeutic platform based on dual-template molecular imprinting that integrates PS-targeted tumor recognition with pH-responsive doxorubicin (Dox) delivery in a single nanocarrier. By co-imprinting the PS polar head group and Dox, the resulting molecularly imprinted polymer nanoparticles (dt-MIP) generate orthogonal binding sites for membrane targeting and drug loading, achieving high binding capacities for PS and Dox (<i>Q</i>_max ∼ 180 mg g^-1 and ∼37 mg g^-1, respectively), high selectivity, minimal drug leakage at physiological pH, and accelerated release in acidic environments. The dt-MIP recognized surface-exposed PS with specificity comparable to Annexin V and enabled PS-dependent Dox delivery across multiple cell lines, with delivery efficiency correlating with the degree of PS externalization. In triple-negative breast cancer cells, Dox-loaded dt-MIP markedly enhanced intracellular drug accumulation and reduced cell viability to ∼8% at 200 μg mL^-1 dt-MIP, compared with ∼70% for free Dox at the same dose. In an MDA-MB-231 xenograft model, dt-MIP achieved tumor-selective accumulation and substantially suppressed tumor growth while maintaining a favorable safety profile. These results establish dual-template molecular imprinting as a general strategy for constructing fully synthetic, target-directed cancer therapeutics, positioning PS-imprinted nanocarriers as an alternative to biologically derived targeting systems.</p>","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interfacial Zr–O–N bonds modulated oxygen vacancies in S-scheme heterojunction for enhanced wastewater purification","authors":"Liping Liang,Zhu Zhu,Sizhuo Wang,Kailian Zhang,Weiya Huang,Kai Yang,Dan Li,Zhao-Qing Liu","doi":"10.1039/d6nr03077g","DOIUrl":"https://doi.org/10.1039/d6nr03077g","url":null,"abstract":"UiO‑66 derived oxygen‑doped g-C3N4(OCN)/t-ZrO2 heterojunctions with Zr–O–N interfacial chemical bonds were successfully prepared via a solid‑state grinding and pyrolysis method. The presence of Zr–O–N bonds induced the generation of abundant oxygen vacancies (Ov), which enhanced the surface adsorption of pollutant molecules. Meanwhile, the Zr–O–N bonds acted as \"electron channels\", optimizing the interfacial contact of the S-scheme heterojunction and suppressing the recombination of photogenerated electron-hole pairs. Moreover, Ov-mediated degradation pathway dominated by singlet oxygen (1O2) and superoxide radicals (·O2−) effectively promoted the efficient degradation and deep mineralization of pollutants, allowing for a triple synergy of “enhanced adsorption–promoted charge separation-regulated reactive species”. After 30 min of dark adsorption followed by 120 min of simulated visible-light irradiation, the optimal sample ZOCN-3 achieved a total adsorption–photocatalytic removal of 95.72% for tetracycline hydrochloride (TC) and 97.58% for methylene blue (MB). Its degradation rate constants for TC and MB were 4.56 and 2.66 times those of t-ZrO2, respectively, with a TOC removal of 61.41% for TC after 120 min. ZOCN-3 also exhibited excellent recyclability, stability, and anti-interference capability. This work offers an interfacial engineering approach to create MOF-derived S-scheme heterojunctions with superior efficacy in treating wastewater.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"31 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-assembled vanadium-graphene hydrogels for high-capacity aqueous zinc-ion batteries.","authors":"Andrew J Sellathurai, Mahmoud Khademi, Mohammad Bandpey, Dominik P J Barz","doi":"10.1039/d6nr02910h","DOIUrl":"https://doi.org/10.1039/d6nr02910h","url":null,"abstract":"<p><p>This work presents a novel strategy for synthesizing vanadium-oxide-based cathode materials for zinc-ion batteries. The synthesis begins with the preparation of a vanadium-graphene hydrogel <i>via</i> hydrothermal reduction of a graphene oxide dispersion containing vanadyl sulfate. In a subsequent hydrothermal step, the resulting vanadate species are converted into hydrated vanadium pentoxide. The obtained vanadium pentoxide-graphene hydrogel composites are thoroughly characterized in terms of their structural and electrochemical properties. At a current density of 0.1 A g^-1, normalized to the entire cathode mass, the material delivers an impressive discharge capacity of 502 mAh g^-1. When normalized to the electroactive vanadium pentoxide content, this value increases to around 670 mAh g^-1. This exceptional performance arises not only from the reversible intercalation of zinc ions into vanadium pentoxide but also from concurrent proton intercalation and the capacitive contribution of the high-surface-area graphene host material.</p>","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Boron-based materials in advanced oxidation processes: From electron deficiency to catalytic versatility","authors":"Yiru Xu,Bo Yang,Yang Liu,Peng Zhou","doi":"10.1039/d6nr02309f","DOIUrl":"https://doi.org/10.1039/d6nr02309f","url":null,"abstract":"Being favorable replacements for traditional metal-based catalysts, boronbased materials have gained increasing attention in advanced oxidation processes (AOPs) for water decontamination, benefiting from their unique electron-deficient 2 structure, strong covalent bonding, excellent chemical stability, and minimal metal leaching. This review comprehensively examines four representative categories of boron-based materials (including elemental boron, metal borides, boron-doped diamond (BDD), and boron nitride) from the fundamental physicochemical properties to their specific applications in various AOPs. Furthermore, the intrinsic mechanisms underlying structure-activity relationships of various boron-based materials, covering electron donation driven metal redox cycling, dual active site synergistic catalysis, and nanoconfined interfacial reactions, are critically elucidated. Finally, the critical challenges impeding the practical implementation of boron-based materials are identified and future research directions are proposed. It is expected that this review can provide a comprehensive reference framework and new inspiration for the scientific design and engineering application of boron-based materials in water remediation.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"30 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-interfering dual-mode luminescence with persistent emission under UV excitation and upconversion thermometry under NIR excitation in Ca3Ga4O9: Pr3+, Er3+, Zn2+","authors":"Shitao Xu,Ran Pang,Zezhi Chen,Xiaoman Shi,Huimin Li,Su Zhang","doi":"10.1039/d6nr03010f","DOIUrl":"https://doi.org/10.1039/d6nr03010f","url":null,"abstract":"The excitation-dependent trapping/detrapping kinetics inherent to persistent luminescence (PersL) materials give rise to non‑unique thermometric spectral responses, rendering PersL and fluorescence thermometry intrinsically incompatible and thereby impeding the development of multifunctional luminescent materials. To overcome this challenge, a multifunctional phosphor, Ca3Ga4O9:Pr3+,Er3+,Zn2+, was developed based on a function-decoupling strategy enabled by distinct excitation modes, successfully integrating PersL with upconversion fluorescence thermometry. Under 254 nm UV excitation, the phosphor exhibits blue-green PersL arising from the combined emission of Pr3+ and Er3+, and Zn2+ co-doping increases the total relative trap density by approximately 13 times, resulting in a pronounced enhancement of the PersL intensity. While under 980 nm excitation, the Er3+ upconversion luminescence enables temperature sensing via the fluorescence intensity ratio (FIR) of the thermally coupled 2H11/2/4S3/2 levels, with a maximum relative sensitivity Sr of 1.64% K-1 at 253 K. The independent excitation pathways for PersL and temperature sensing avoid the signal interference under the designated operating conditions. The phosphor integrates UV excitation wavelength-dependent color tunability, PersL, and NIR-excited temperature-sensitive optical thermometry. This multifunctional feature offers a novel strategy for combining multiple optical functionalities within a single luminescent system and may provide a basis for future exploration in optical identification and temperature sensing","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"11 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering charge transfer pathways in anion exchanged CsPbBr_3-<i>x</i>Cl_<i>x</i> perovskite nanocrystals with fullerene.","authors":"Priyanka Dubey, Ambika Prasad Kar, Himanshu Kumar, Soumi Dutta, Pramit Kumar Chowdhury, Manas Kumar Sarangi","doi":"10.1039/d6nr02079h","DOIUrl":"https://doi.org/10.1039/d6nr02079h","url":null,"abstract":"<p><p>The optoelectronic efficacies of lead halide perovskite nanocrystal (PNC)-driven devices are often assessed by the interfacial charge-transfer (CT) dynamics between the active layer and the adjacent charge-transporting layers. Enhanced device performance typically requires efficient charge-carrier generation, swift CT dynamics, effective carrier extraction, and reduced recombination losses. In the current study, we have attempted to unveil the underlying photoinduced CT kinetics among the compositionally tuned CsPb(Br/Cl)₃ PNCs with fullerene (C₆₀) through a series of steady-state and time-resolved spectroscopic and conductivity measurements along with simulations. Among the investigated systems, the mixed-halide CsPb(Br/Cl)₃ PNCs exhibit a markedly higher CT rate with C₆₀ compared to their pristine CsPbBr₃ and CsPbCl₃ counterparts. The analysis further uncovers signatures of both electron and hole transfer processes at the CsPb(Br/Cl)₃-C₆₀ interface, indicating a more efficient dual-channel deactivation pathway. Conductive atomic force microscopy shows enhanced conductivity and the most significant relative resistance reduction for CsPb(Br/Cl)₃-C₆₀, evidencing superior charge injection and transport. Complementarily, a one-dimensional solar cell capacitance simulator (SCAPS-1D) further reveals that incorporation of C₆₀ enhances the photovoltaic parameters, with the CsPb(Br/Cl)₃-based device showing the most pronounced improvement, in agreement with the spectroscopic and conductance measurements. These results provide crucial insights into strategies for tailoring PNC-based optoelectronic devices towards higher efficiency while highlighting the critical influence of CT in governing charge transport and device performance.</p>","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA origami as an electronically coupled scaffold for Au nanocluster electrocatalysts.","authors":"Shikha Rai, Ritu Raj, Aneena Alottu Padikkal, Kousik Giri, Tapasi Sen, Krishna Kanta Haldar","doi":"10.1039/d6nr03032g","DOIUrl":"https://doi.org/10.1039/d6nr03032g","url":null,"abstract":"<p><p>Ultra-small, atomically precise gold nanoclusters (Au NCs) offer distinctive opportunities for electrocatalysis owing to their discrete electronic structures and high density of coordinatively unsaturated sites; however, uncontrolled aggregation and the absence of spatial control over cluster nucleation on conventional supports remain significant challenges for the rational engineering of catalytic interfaces. Herein, we report a site-directed, <i>in situ</i> strategy for the spatially controlled synthesis of Au NCs on DNA origami (Au NC@DNA) scaffolds, which function as localized nucleation and coordination platforms to afford Au NC@DNA origami hybrid architectures. The resulting hybrids exhibit a narrowly distributed Au NC size of 1.5 ± 0.2 nm, as established by complementary UV-vis and fluorescence spectroscopy, atomic force microscopy (AFM), transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS). When evaluated for the hydrogen evolution reaction (HER) in 0.5 M H₂SO₄, the Au NC@DNA origami hybrid exhibits a low overpotential of 87 mV at a current density of -10 mA cm^-2, together with a Tafel slope of 67 mV dec^-1, a charge-transfer resistance of 13.87 Ω, and a mass activity of 416.3 A g^-1. These electrocatalytic metrics substantially exceed those of Au NC@Poly-C, pristine DNA origami, and poly-cytosine (poly-C) controls and approach the performance of the benchmark Pt/C catalyst. Furthermore, the Au NC@DNA origami catalyst demonstrates pronounced operational durability, maintaining its electrocatalytic activity over 3000 continuous linear sweep voltammetry cycles and 36 h of chronoamperometric operation. Density functional theory (DFT) calculations identify the DNA-Au₂₁ configuration as a thermodynamically favorable catalytic motif, characterized by a near-thermoneutral Gibbs free energy of hydrogen adsorption (Δ<i>G</i>_H*). Bader charge analysis and projected density of states (PDOS) further reveal substantial electronic coupling between the Au cluster and DNA ligand, accompanied by Au-H orbital hybridization and charge redistribution involving neighbouring N/O coordination sites. These results demonstrate that DNA origami functions not merely as a structural template but as an electronically coupled and catalytically relevant scaffold that modulates the physicochemical properties of atomically precise Au nanoclusters.</p>","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary electron imaging in transmission electron microscopy: technique and application in nanocatalysis.","authors":"Ilya V Pankov, Arshak A Tsaturyan","doi":"10.1039/d6nr01913g","DOIUrl":"10.1039/d6nr01913g","url":null,"abstract":"<p><p>The determination of the smallest structures and surface morphologies of nanoparticles using Transmission Electron Microscopy (TEM) is widely regarded as one of the most essential techniques for modern researchers. Despite its proven scientific effectiveness, TEM has certain limitations, the main one of which is that the analysis of nanoparticles or their agglomerates - in fact three-dimensional structures - results in two-dimensional images, which may not fully reflect their complex geometries. A promising solution to this problem lies in the integrated on modern TEM devices secondary electron (SE) detectors. These detectors, optimized for capturing low-energy secondary electrons, function similarly to those in Scanning Electron Microscopy. Complementing high-resolution TEM or STEM images, the SE detector provides three-dimensional images with a resolution close to or equal to atomic, while allowing avoidance of the labor-intensive and time-consuming processes associated with TEM-based 3D tomography, for example. With current advancements in detector technology, secondary electron imaging holds significant potential as a primary tool for investigating the morphology of a wide spectrum of nanomaterials, including nanoparticles and powders, paving the way for broader applications in nanoscience and materials research. In this review, we will briefly cover the features of the method and its main physical principles, and recent advances in its application in nanocatalysis with platinum group metals-based catalysts, where the application of this method could be revolutionary. The distribution of metal nanoparticles on the carbon or other support is a critical factor directly affecting the performance of these materials. And, as practice shows, traditional TEM often fails to provide comprehensive information on their morphology.</p>","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":" ","pages":"21043-21058"},"PeriodicalIF":5.2,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changing nano-scape in Asia: the future is here","authors":"Thalappil Pradeep,Kaoru Tamada,Haiwon Lee,Dong-Hwan Kim","doi":"10.1039/d6nr90137a","DOIUrl":"https://doi.org/10.1039/d6nr90137a","url":null,"abstract":"Thalappil Pradeep, Kaoru Tamada, Haiwon Lee and Dong-Hwan Kim introduce the Nanoscale themed collection on the changing canvas of nano.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"13 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated experimental, first-principles study, and machine learning investigation of thermally optimized CoMoO for supercapacitors","authors":"Nagendra Babu A. P.,Rajesh B. M.,Shwetha Kollur Prabhakar Rao,C. G. Renuka","doi":"10.1039/d6nr02218a","DOIUrl":"https://doi.org/10.1039/d6nr02218a","url":null,"abstract":"The precise control of crystallinity and electronic structure in transition-metal molybdates is still a fundamental challenge in the development of high-performance supercapacitor electrodes. We herein report a dwell-time modulated thermal decomposition strategy to achieve phase-pure CoMoO4 with tuneable crystallinity-electronic structure coupling for advanced energy storage applications. Among the synthesised samples, CM3 showed an optimised monoclinic phase with reduced microstrain and a vertically oriented nanosheet morphology, allowing rapid ion diffusion and better electrochemical accessibility. Density functional theory calculations revealed vacancy-induced Co 3d–Mo 4d–O 2p orbital hybridisation, which promoted charge delocalisation near the Fermi level and accelerated charge-transfer kinetics. Benefiting from these synergistic structural and electronic features, the CM3 electrode delivered a high specific capacitance of 545.94 F g−1 at 1 A g−1 with 93.28% capacitance retention after 10 000 cycles. Furthermore, the assembled asymmetric CoMoO4//AC supercapacitor achieved a wide operating voltage window of 1.8 V and a high energy density of 64.74 Wh kg−1 with excellent cycling stability. The device also demonstrated practical feasibility by powering a real-time RGB sensing platform. In addition, a physics-informed Random Forest model exhibited strong predictive accuracy across electrochemical datasets, highlighting the potential of integrating data-driven modelling with experimental materials design.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"62 4 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}