Nanoscale最新文献_第2页

Antimicrobial Peptide-Conjugated Graphene Coatings for Prevention and Treatment of Bacterial Infections 抗菌肽共轭石墨烯涂层用于预防和治疗细菌感染

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-07-31 DOI: 10.1039/d5nr01674f

Xiao Zhu, Dai Thien Nhan Tram, Dhanya Mahalakshmi Murali, Veluchamy Amutha Barathi, Venkatesh Mayandi, Rajamani Lakshminarayanan, Pui Lai Rachel Ee

{"title":"Antimicrobial Peptide-Conjugated Graphene Coatings for Prevention and Treatment of Bacterial Infections","authors":"Xiao Zhu, Dai Thien Nhan Tram, Dhanya Mahalakshmi Murali, Veluchamy Amutha Barathi, Venkatesh Mayandi, Rajamani Lakshminarayanan, Pui Lai Rachel Ee","doi":"10.1039/d5nr01674f","DOIUrl":"https://doi.org/10.1039/d5nr01674f","url":null,"abstract":"Graphene, a two-dimensional hexagonal lattice of carbon atoms, displays remarkable physicochemical properties. In contrast to classical chemical exfoliation, chemical vapour deposition (CVD) technology has enabled the production of continuous transparent graphene. CVD graphene coatings on biomedical devices such as contact lenses (CLs) offer several advantages, such as shielding from electromagnetic wave interference and dehydration protection. However, its protective effect against bacteria adhesion remains unexplored. In this study, we designed a series of antimicrobial peptide (AMP)-modified CVD graphene coating on polydimethylsiloxane (PDMS), a biocompatible CLs material. AMPs were successfully conjugated on CVD graphene coating, with negligible impact on the light transmittance. The resultant coating displayed contact angles of less than 50° and protein deposition of less than 9.4 µg cm-2, indicating transparency, wettability, and protein deposition suitable for biomedical devices. AMPs conjugation on the graphene surface prevented biofilm formation by Pseudomonas aeruginosa (P. aeruginosa), as evidenced by lower colony counts and bacterial metabolic activity. The antimicrobial activity and biocompatibility of the coatings were further demonstrated using ex vivo porcine skins and in vivo rabbit eyes respectively. Overall, this study highlights the potential of AMP-modified CVD graphene coating to minimize bacterial infection and prevent biofilm formation.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"718 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Femtosecond Laser Constructed Bioinspired Gradient Wedge-Shaped Surfaces for Under-Oil Liquid Self-Transport 飞秒激光构建油下液体自输运生物启发梯度楔形表面

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-07-31 DOI: 10.1039/d5nr02015h

Wei Xiong, Ruisong Jiang, Weixin Sun, Xuqiao Peng, Shuai Bi, Chaolang Chen

{"title":"Femtosecond Laser Constructed Bioinspired Gradient Wedge-Shaped Surfaces for Under-Oil Liquid Self-Transport","authors":"Wei Xiong, Ruisong Jiang, Weixin Sun, Xuqiao Peng, Shuai Bi, Chaolang Chen","doi":"10.1039/d5nr02015h","DOIUrl":"https://doi.org/10.1039/d5nr02015h","url":null,"abstract":"The spontaneous transport of liquids holds significant application potential in biomedicine, heat dissipation, microfluidic chips, and so forth. Particularly, the under-oil liquid self-transport is a significant pathway for manipulating the volatile liquids. Although numerous functional surfaces have been developed to facilitate the directional self-transport of liquids (e.g., water, oil) in the air, reports on the self-transport of liquids in oily environments remain scarce. Herein, inspired by the lotus leaves and cactus spines, we propose a bionic superwetting gradient wedge-shaped surface (SGWS) for under-oil self-transport of liquids. The SGWS was fabricated through a combination of femtosecond laser texturing and hydrophobic modification. The as-prepared SGWS can achieve fast and continuous self-transport of a single droplet under-oil, exhibiting a maximal transport velocity of over 250 mm/s and transport distance of over 150 mm. The effect of wedge-shaped angle, inclined angle, and surface tension on the self-transport behavior of liquid on the SGWS was systematically investigated and the underlying mechanism was revealed. Furthermore, the potential applications of the SGWS in complex fluid manipulation, droplet microchemical reactions, cargo transport, and oil surface particles collection were explored in detail. This work offers a novel strategy for realizing under-oil liquid manipulation without energy input, showing promising applications in the industry.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"26 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficient and rapid recovery of scandium from acidic wastewater using β-cyclodextrin-based phosphorus-functionalized covalent organic polymer 利用β-环糊精基磷功能化共价有机聚合物高效、快速回收酸性废水中的钪

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-07-31 DOI: 10.1039/d5nr01536g

Ke Liu, Shuai Qin, Lijin Huang

{"title":"Efficient and rapid recovery of scandium from acidic wastewater using β-cyclodextrin-based phosphorus-functionalized covalent organic polymer","authors":"Ke Liu, Shuai Qin, Lijin Huang","doi":"10.1039/d5nr01536g","DOIUrl":"https://doi.org/10.1039/d5nr01536g","url":null,"abstract":"Motivated by the growing demand for rare earth elements (REEs), it is crucial to design effective adsorbents capable of separating and reclaiming REEs from acidic wastewater. Herein, a phosphorus-functionalized covalent organic polymer (β-HCCD) was successfully synthesized via a straightforward nucleophilic substitution reaction, utilizing two cost-effective monomers β-cyclodextrin (β-CDs) and hexachlorocyclotriphosphazene (HCCP). Owing to the presence of abundant P-O bonds in β-HCCD and the unique cavity structure of β-CDs, β-HCCD exhibits adsorption efficiency exceeding 98% for scandium ions (Sc³⁺) within acidic solution with the hydrogen ion concentrations ranging from 5 mol·L-1 to 10⁻5 mol·L-1. Meanwhile, the complete capture of Sc3+ by β-HCCD can be accomplished within 2 minutes, and the adsorption isotherms demonstrated an outstanding alignment with the Freundlich model, exhibiting a maximum adsorption capacity of 101.0 mg·g⁻¹. What’s more, β-HCCD can be directly applied to industrial acidic wastewater without prior pretreatment, achieving an efficient recovery rate of 87% for Sc3+. These notable advantages including minimal expense, straightforward preparation process, fast adsorption dynamics and substantial adsorption ability demonstrate that β-HCCD holds significant promise for the recovery of REEs.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"27 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in photocatalytic ammonia synthesis: Materials design and mechanism insight 光催化合成氨的新进展：材料设计和机理研究

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-07-31 DOI: 10.1039/d5nr02673c

Haipeng Zuo, Hao Zhou, Bo Lin, Wei Jiang, Jun Di

{"title":"Recent advances in photocatalytic ammonia synthesis: Materials design and mechanism insight","authors":"Haipeng Zuo, Hao Zhou, Bo Lin, Wei Jiang, Jun Di","doi":"10.1039/d5nr02673c","DOIUrl":"https://doi.org/10.1039/d5nr02673c","url":null,"abstract":"Ammonia, a core raw material for the global agricultural and chemical industries, faces serious challenges in its conventional synthesis process (Haber-Bosch method) due to its high energy consumption, high carbon emissions and dependence on fossil fuels. Photocatalytic ammonia synthesis technology provides a revolutionary solution for green ammonia economy by realizing efficient nitrogen reduction under mild conditions with solar energy as the driving force. In this paper, we systematically review the mechanism of photocatalytic nitrogen reduction reaction, focusing on the adsorption activation of nitrogen molecules, electron transfer pathways, and intermediate product regulation strategies, and review multiple types of photocatalyst systems including metal oxides, sulfides, bismuth-based materials, and carbon-based materials. Modification strategies such as defect engineering, single-atom modification, heterojunction design and plasma effect can significantly optimize the light absorption range, suppress carrier recombination and enhance the active site density. It is further pointed out that the existing catalytic systems still face bottlenecks such as low quantum efficiency, photocorrosion, and scale-up reactor design, and the future needs to promote the photocatalytic synthesis of ammonia from the laboratory to the industrialization through the multiscale synergistic innovation. This study provides theoretical guidance and practical framework for the design and development of an efficient and stable photocatalytic ammonia synthesis system, which is scientifically important for achieving the goal of carbon neutrality.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"1 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Catalase enzyme-modified carbon quantum dot nanoparticles with hypoxia alleviating, associated with indocyanine green for synchronous augmented photodynamic therapy and cell imaging of melanoma cancer 过氧化氢酶修饰的碳量子点纳米颗粒具有缺氧缓解作用，与吲哚菁绿相关，用于黑色素瘤癌的同步增强光动力治疗和细胞成像

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-07-31 DOI: 10.1039/d5nr02133b

Hadiseh Mehravanfar, Nafiseh Farhadian, Khalil Abnous, Taraneh sadat Zavvar

{"title":"Catalase enzyme-modified carbon quantum dot nanoparticles with hypoxia alleviating, associated with indocyanine green for synchronous augmented photodynamic therapy and cell imaging of melanoma cancer","authors":"Hadiseh Mehravanfar, Nafiseh Farhadian, Khalil Abnous, Taraneh sadat Zavvar","doi":"10.1039/d5nr02133b","DOIUrl":"https://doi.org/10.1039/d5nr02133b","url":null,"abstract":"The aim of this study was to synthesize carbon quantum dot nanoparticles (CQD NPs) with high quantum yield and conjugate it with catalase (CAT) enzyme for cell imaging and photodynamic therapy (PDT) application. CQD was synthesized by hydrothermal method and purified with a novel method to obtain high quantum yield. Indocyanine green (ICG) was loaded on the CQD as a proper photosensitizer for PDT and CAT enzyme was applied to generate oxygen in the tumor site. Then, the efficacy of the synthesized NPs for photodynamic therapy (PDT) and cell imaging of melanoma cancer cells was investigated at in vitro, ex vivo and in vivo environment. Characterization results confirmed that the hydrodynamic size of CAT-ICG@CQD particles were about 51.3 nm. In addition, the reactive oxygen species (ROS) detection analysis 1demonstrated that free ICG’s ROS generation capacity enhanced extremely (26%) after CAT conjunction. Moreover, cell culture assessments displayed that CAT-ICG@CQD could precisely decrease melanoma cell viability up to 15.66% laser illumination triggered in semitumor microenvironment resulting in higher cellular uptake, sustainable release and more ROS generation capacity in comparison to free ICG. Cell imaging analysis illustrated the high fluorescence intensity of ICG in cytoplasm for CAT-ICG@CQD, approving the high quantum yield and more ICG cell entrance than free ICG. The in vivo study on C57BL/6 mice containing melanoma cancer elucidated that CAT-ICG@CQD has superior inhibitory ability for the tumor growth by tumor oxygenation, implying efficient PDT with hypoxia alleviating. The outcome of the present study provided a novel nano-platform for ameliorating the tumor hypoxia, which meet demands of melanoma PDT by high efficiency of ROS generation and cell imaging capability.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"11 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tip-Induced Nanoscale Engineering of Surface Potential and Conductivity in GeSn Alloys 尖端诱导的GeSn合金表面电位和电导率纳米工程

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-07-31 DOI: 10.1039/d5nr01090j

Serhiy Kondratenko, Peter Lytvyn, Serhii Maliuta, Morgan E. Ware, Shui-Qing Fisher Yu, Fernando Maia de Oliveira, Andrian Kuchuk, Oleksandr I. Datsenko, Yuriy Mazur, Gregory J. Salamo

引用次数: 0

Humidity-stable submicron magnesium oxide particles for high-performance thermally conductive composites 用于高性能导热复合材料的湿度稳定的亚微米氧化镁颗粒

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-07-31 DOI: 10.1039/d5nr02016f

Ji-Yun Jeon, Ye-Rang Kwak, Da-Gyeong Shin, Hyun-Ae Cha, Jong-Jin Choi, Byung-Dong Hahn, Cheol-Woo Ahn, Young Kook Moon

{"title":"Humidity-stable submicron magnesium oxide particles for high-performance thermally conductive composites","authors":"Ji-Yun Jeon, Ye-Rang Kwak, Da-Gyeong Shin, Hyun-Ae Cha, Jong-Jin Choi, Byung-Dong Hahn, Cheol-Woo Ahn, Young Kook Moon","doi":"10.1039/d5nr02016f","DOIUrl":"https://doi.org/10.1039/d5nr02016f","url":null,"abstract":"While spherical MgO microparticles provide high fluidity and dispersibility within polymer matrices, submicron MgO particles confer superior thermal conductivity to thermally conductive composites by increasing the number of particle contact points and optimizing the heat transport pathways. However, the effectiveness of submicron MgO particles as heat-dissipating agents is limited by conventional fabrication methods, which often fail to prevent moisture reactivity. In this study, we introduce a novel bottom-up approach for the synthesis of submicron MgO particles with superlative humidity resistance and thermal conductivity. Spray drying a polymeric precursor solution synthesized via the polymerization of citric acid and ethylene glycol followed by a two-step heat treatment involving oxidation and liquid-phase sintering affords MgO particles with dense morphologies and excellent humidity resistance (1.03% weight variation). These submicron-scale, humidity-stable MgO particles significantly enhance the thermal conductivity of a polydimethylsiloxane matrix, achieving 6.0 W m−1 K−1 at 80 vol% filler content, significantly higher than that of composites without submicron MgO at the same filler content (4.4 W m−1 K−1). The submicron MgO particles also provide additional electrical insulation; thus, this synthetic method is expected to facilitate the development of high-performance ceramic fillers for advanced heat management applications in next-generation electronic devices.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"68 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced Optical Waveguide Design via Encapsulation of 2,4,6-Triphenylpyrylium Chloride in Oxide Glasses 基于2,4,6-三苯基氯化铕在氧化玻璃中封装的先进光波导设计

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-07-31 DOI: 10.1039/d5nr02213d

Eleni Agapaki, Ioannis Konidakis, Egor Evlyukhin, Klytaimnistra Katsara, George Kenanakis, David King, Haesook Han, Pradip K. Bhowmik, Emmanuel Stratakis

{"title":"Advanced Optical Waveguide Design via Encapsulation of 2,4,6-Triphenylpyrylium Chloride in Oxide Glasses","authors":"Eleni Agapaki, Ioannis Konidakis, Egor Evlyukhin, Klytaimnistra Katsara, George Kenanakis, David King, Haesook Han, Pradip K. Bhowmik, Emmanuel Stratakis","doi":"10.1039/d5nr02213d","DOIUrl":"https://doi.org/10.1039/d5nr02213d","url":null,"abstract":"Pyrylium ion (C5H5O+) based salts exhibit distinctive optical properties that can be tuned by external stimuli such as temperature and pressure, making them suitable materials for various nanoscale optoelectronic applications. However, their practical use has been limited by their solid powdered form, which poses challenges for integration into realistic devices. Herein, we present a low-temperature, post-melting encapsulation method for the incorporation of 2,4,6-triphenylpyrylium chloride salt within transparent phosphate glasses containing dispersed silver nanoparticles. This synthesis approach enables spatially controlled vitrification of high- refractive index pyrylium pathways within the glass matrix. The encapsulated salt retains its structural and optical properties, while the presence of randomly dispersed silver nanoparticles enhances light transmission upon scattering effects. The resulting pyrylium salt-glass composited exhibit robust waveguiding characteristics, positioning this technique as a promising route for the fabrication of advanced nano-engineered optoelectronic devices.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"27 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of composition and diameter on the crystal purity of InAsxP1-x nanowires 成分和直径对InAsxP1-x纳米线晶体纯度的影响

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-07-31 DOI: 10.1039/d5nr02409a

Giada Bucci, Vladimir G. Dubrovskii, Valentina Zannier, Fabio Beltram, Lucia Sorba

{"title":"The role of composition and diameter on the crystal purity of InAsxP1-x nanowires","authors":"Giada Bucci, Vladimir G. Dubrovskii, Valentina Zannier, Fabio Beltram, Lucia Sorba","doi":"10.1039/d5nr02409a","DOIUrl":"https://doi.org/10.1039/d5nr02409a","url":null,"abstract":"Ternary InAsxP1-x nanowires are widely considered as promising building blocks for fundamental studies and applications in nano- and optoelectronics. However, it is admittedly challenging to maintain the necessary control over the crystal purity of nanowires. Furthermore, the crystal phase trends in ternary III-V nanowires remain generally unknown. In this work, we present wurtzite InAsxP1-x nanowires with different compositions x, ranging from 0 to 0.54, grown via chemical beam epitaxy on InP(111)B substrates using Au colloidal catalysts of different diameters. Transmission electron microscopy studies reveal that pure wurtzite phase of the nanowires requires larger InAs fractions x for larger diameters of Au colloids (in particular, x=0.36 for 20 nm diameter and x=0.54 for 30 nm diameter Au colloids). We develop a model for the critical composition of thin vapor-liquid-solid III-V ternary nanowires x_c corresponing to the transition from a polytypic structure at x < x_c to pure wurtzite structure at x > x_c. For InAsxP1-x material, the critical composition increases with the nanowire diameter, which explains our experimental findings. These results shed more light on the composition and diameter dependent polytypism, offering valuable insights for the design and crystal phase control of InAsxP1-x and other III-V ternary nanowires.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"151 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fine-Tuning Ni/Co Ratio to Elucidate the Coordination Structure-Activity Relationship of MOF-derived Bimetallic Layered Double Hydroxide for Highly Sensitive Enzyme-free Lactate Biosensors 微调Ni/Co比值阐明mof衍生的高敏感无酶乳酸生物传感器双金属层状双氢氧化物配位构效关系

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-07-31 DOI: 10.1039/d5nr01364j

Yi-Ting Guo, Mia Rinawati, Ling-Yu Chang, Chieh Li, Ching-Ju Ho, Ping-Chen Shi, Kuan-Jung Chen, Wei-Hsiang Huang, Hitoshi Mizuguchi, Min-Hsin Yeh

{"title":"Fine-Tuning Ni/Co Ratio to Elucidate the Coordination Structure-Activity Relationship of MOF-derived Bimetallic Layered Double Hydroxide for Highly Sensitive Enzyme-free Lactate Biosensors","authors":"Yi-Ting Guo, Mia Rinawati, Ling-Yu Chang, Chieh Li, Ching-Ju Ho, Ping-Chen Shi, Kuan-Jung Chen, Wei-Hsiang Huang, Hitoshi Mizuguchi, Min-Hsin Yeh","doi":"10.1039/d5nr01364j","DOIUrl":"https://doi.org/10.1039/d5nr01364j","url":null,"abstract":"The development of a reliable, non-enzymatic electrochemical sensor for lactate detection is crucial for real-time monitoring of muscle fatigue and human metabolism. In this work, we present a straightforward and controllable synthesis method for nickel–cobalt bimetallic layered double hydroxide (LDH) derived from a metal-organic framework (MOF) precursor in an alkaline medium. The Ni/Co ratio was systematically tuned to induce distinct hydroxide phase transformations, where a high Ni content favored the formation of the α-phase hydroxide with superior catalytic activity, while a high Co ratio led to β-phase hydroxide formation. Advanced X-ray absorption spectroscopy (XAS) and Raman analyses revealed that the optimized Ni-rich LDH exhibited a unique mixed octahedral (Oh)/tetrahedral (Td) coordination, with a tetrahedral-dominant structure that enhanced charge transfer and electronic conductivity. Additionally, the Ni-rich LDH facilitated the formation of trivalent metal (Ni3+/Co3+) species, promoting stronger redox activity essential for lactate oxidation. The optimized Ni-rich LDH modified screen-printed carbon electrode demonstrated outstanding electrochemical performance, achieving a high sensitivity of 63.66 ± 3.86 µA mM⁻¹ within a lactate concentration range of 0~12.5 mM at an applied potential of 0.60 V (vs. Ag/AgCl/3 M KCl) in alkaline medium. Furthermore, as proposed biosensor exhibited excellent repeatability, maintaining 85.70% of its initial response after 18 days under room temperature, highlighting its remarkable stability for long-term applications. This study provides valuable insights into the structure-activity relationship of MOF-derived LDHs and offers a promising pathway for developing high-performance, enzyme-free lactate biosensors for non-invasive monitoring of physiological conditions.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"140 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0