Nanoscale最新文献_第2页

Effect of γ-irradiation on hexagonal boron nitride membranes and printed films. γ辐照对六方氮化硼膜及印刷膜的影响。

IF 5.8 3区材料科学

Nanoscale Pub Date : 2025-07-02 DOI: 10.1039/d5nr01542a

Jingjing Wang, Towseef I Ahmad, William Lee, Benjamen P Reed, Yashoda Abeykoon, Khaled Parvez, Zixing Peng, Andrew J Pollard, Aliaksandr Baidak, Jordan Knapp, Cinzia Casiraghi

{"title":"Effect of γ-irradiation on hexagonal boron nitride membranes and printed films.","authors":"Jingjing Wang, Towseef I Ahmad, William Lee, Benjamen P Reed, Yashoda Abeykoon, Khaled Parvez, Zixing Peng, Andrew J Pollard, Aliaksandr Baidak, Jordan Knapp, Cinzia Casiraghi","doi":"10.1039/d5nr01542a","DOIUrl":"https://doi.org/10.1039/d5nr01542a","url":null,"abstract":"Liquid phase exfoliation (LPE) enables cost-effective and scalable production of two-dimensional (2D) materials that are suitable for fabrication of protection films and barrier coatings, through simple and low-cost techniques. Amongst 2D materials, hexagonal boron nitride (hBN) is very attractive for these applications due to its exceptional thermal and chemical stability. However, use of hBN coatings and films in environments such as reactor inspection, spent nuclear fuel handling, reprocessing facilities, or spacecraft components, which often involve elevated temperatures and/or the presence of reactive chemical species, require the protective coatings to retain their chemical, mechanical, or thermal performance under prolonged radiation exposure. In this study, we investigate the radiation tolerance to γ-rays of printed hBN films fabricated by inkjet printing and membranes produced by vacuum filtration, up to a total absorbed dose of 1500 kGy in different atmospheric conditions. Raman spectroscopy and X-ray photoelectron spectroscopy (XPS) reveal no significant structural differences in the samples up to the maximum absorbed dose, indicating excellent radiation tolerance under the conditions tested. Additionally, we did not observe structural changes in the irradiated hBN films even after prolonged exposure to air for two months. The exceptional radiation tolerance and environmental stability of the printed hBN films and membrane make them attractive as protective coatings or insulating layers in various advanced technologies for the nuclear and aerospace sectors, where long-term material stability to γ-rays is crucial.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Progress of Norcantharidin Nanodrugs for Tumor Treatment 去甲斑蝥素治疗肿瘤纳米药物的研究进展

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-07-02 DOI: 10.1039/d5nr01530h

Zhiyu Xia, Hao-Liang Peng, Yong You, Lu Zhang, Qiu-Ying Deng, Lei Zhou, Silin Chen, Xin-Yi Guo, Jingxing Guo, Dong-Bing Cheng

{"title":"Research Progress of Norcantharidin Nanodrugs for Tumor Treatment","authors":"Zhiyu Xia, Hao-Liang Peng, Yong You, Lu Zhang, Qiu-Ying Deng, Lei Zhou, Silin Chen, Xin-Yi Guo, Jingxing Guo, Dong-Bing Cheng","doi":"10.1039/d5nr01530h","DOIUrl":"https://doi.org/10.1039/d5nr01530h","url":null,"abstract":"Globally, cancer remains the main cause of death, and although a range of therapeutic options are available, conventional approaches often encounter significant limitations. Norcantharidin (NCTD), a small molecule with a wide range of biological properties, holds great promise in the field of antitumor therapy, but its poor solubility and short half-life limit its clinical application. However, combining drug nanotechnology with the anti-tumor effect of NCTD can significantly improve its bioavailability as well as stability and targeting. This article reviews the main preparation methods of NCTD-based nanodrugs and their application progress in tumor therapy, including prodrug modification, encapsulation delivery, immunotherapy, combination therapy, and derivative expansion. Through in-depth study of related literature, it is found that NCTD nanodrugs have great research potential and broad clinical application prospects. With the continuous development of nanotechnology and biomedicine, the clinical application potential of such drugs will be further studied and discussed, and this exploration is expected to generate new strategies and methods for tumor treatment.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"47 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144533998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Luminescent insulin-Au(III) conjugate retains insulin biological properties in human microglia. 发光胰岛素- au （III）偶联物在人小胶质细胞中保留胰岛素生物学特性。

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-07-02 DOI: 10.1039/d5nr01662b

Dusica Maysinger,Issan Zhang,Hao Yuan,Vlasta Bonačić-Koutecký,Željka Sanader Maršić,Rodolphe Antoine

{"title":"Luminescent insulin-Au(III) conjugate retains insulin biological properties in human microglia.","authors":"Dusica Maysinger,Issan Zhang,Hao Yuan,Vlasta Bonačić-Koutecký,Željka Sanader Maršić,Rodolphe Antoine","doi":"10.1039/d5nr01662b","DOIUrl":"https://doi.org/10.1039/d5nr01662b","url":null,"abstract":"The aims of this study were to establish if insulin conjugated with auric gold Au(III) can be visualized in living cells expressing insulin receptors, and if key steps in insulin signaling are undisturbed. Au(III) is coordinated with three tyrosines of insulin and is strongly stabilized by coordination with these tyrosines into a metal-ion coordinated insulin template. We combined theoretical and experimental approaches, including computational analyses, immunocytochemistry and functional assays to analyze the cellular effects of this construct. Results in this study show that the insulin-Au(III) conjugate does not impair several steps in insulin signaling and downstream metabolic functions in lysosomes and lipid droplets. Namely, the signaling kinases protein kinase B (Akt1) and mitogen-activated protein kinases (ERK1/2) are phosphorylated to a comparable extent as with unmodified insulin. Immunocytochemistry also shows a comparable decrease in nuclear transcription factor EB (TFEB), an essential regulator of lysosomal biogenesis. Fluorescence co-labelling of lysosomes with LysoTracker and lipid droplets with BODIPY 493/503 shows normal organellar morphology and slightly enhanced lipid droplet content. The luminescent properties of insulin-Au(III) could serve to combine biochemical and imaging studies in human cells beyond microglia.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"9 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144533446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MINFLUX: µs and nm precision 3D tracking of dynamic lipid mobility on nanoparticles MINFLUX：纳米颗粒上动态脂质迁移的µs和nm精度3D跟踪

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-07-02 DOI: 10.1039/d5nr00948k

Laurence W. Fitzpatrick, Laura Woythe, Ziqiang Huang, Timo Zimmermann, Lorenzo Albertazzi, Sebastian Schnorrenberg

引用次数: 0

Single atom coordination in a manganese-cobalt bi-metallic framework on graphene: geometric and electronic structures 石墨烯上锰钴双金属框架的单原子配位：几何和电子结构

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-07-02 DOI: 10.1039/d5nr01383f

Stefania Baronio, Michela De Col, Asha Yadav, Basant Roondhe, Valentine Mischke, Olga Resel, Davide Bidoggia, Alessandro Namar, Nikolay Vinogradov, Mattia Scardamaglia, S. Manuel Valvidares, Pierluigi Gargiani, Mirko Cinchetti, Giovanni Zamborlini, Paolo Giannozzi, Erik Vesselli

引用次数: 0

Thermotransmittance spectroscopy of layered crystals using lab on fiber. 层状晶体的热透射光谱研究。

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-07-02 DOI: 10.1039/d5nr00301f

K Ciesiołkiewicz,J Kopaczek,R Kudrawiec

引用次数: 0

Robust spin-filtering and current-switching in a photochromic Fe(II) spin-crossover complex 光致变色Fe（II）自旋交叉配合物的鲁棒自旋滤波和电流开关

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-07-02 DOI: 10.1039/d5nr00781j

Jing Huang, Yiting Zhuo, Mingdi Yang, Weiyi Wang, Qunxiang Li

{"title":"Robust spin-filtering and current-switching in a photochromic Fe(II) spin-crossover complex","authors":"Jing Huang, Yiting Zhuo, Mingdi Yang, Weiyi Wang, Qunxiang Li","doi":"10.1039/d5nr00781j","DOIUrl":"https://doi.org/10.1039/d5nr00781j","url":null,"abstract":"Transition metal spin-crossover (SCO) complexes with magnetic bistability show great promise as spin-switches for molecule-based devices. Using first-principles calculations combined with the non-equilibrium Green's function technique, we explore the spin-resolved electronic and transport properties of photochromic Fe(II) SCO complexes in the high-spin state with the open-ring (HS-O) isomer and in the low-spin state with the closed-ring (LS-C) isomer, since the photocyclization and photocycloreversion between the HS-O and LS-C isomers can been reversibly realized under light radiation with different wavelengths at room temperature in previous experiments. Our results clearly reveal that the examined Fe(II) SCO complexes with photochromic diarylethene-based ligands in the HS-O isomer is lower than that of the LS-C isomer of 0.59 eV. A nearly-perfect spin-filtering effect are observed in the proposed molecular junction in the HS-O isomer, in which the Fe(II) SCO complexes are sandwiched between two Au(111) electrodes. The current is carried predominantly by the spin-down electrons within the considered bias voltages, while the spin-up electrons are largely inhibited due to localized molecular orbitals near the Fermi level. At the same time, we also observe an obvious current-switching effect between the HS-O and LS-C isomers, since the current through the molecular devices in the HS-O isomer (acting as ON state) is significantly larger than that of in the LS-C isomer (OFF state). These findings highlight the great potential for this kind of photo-driven SCO complexes in future molecular spintronics.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"87 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144533996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conformality limits of 2D WS2 on 3D nanostructures 二维WS2在三维纳米结构上的适形限制

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-07-01 DOI: 10.1039/d5nr01013f

Jeff Schulpen, Saravana Basuvalingam, Marcel A. Verheijen, Ageeth A. Bol

引用次数: 0

Ultrathin MXene Conductive Films with Percolation-Driven Electron Transport and Thickness-Dependent Microwave Absorption/Shielding Dual Functionality 超薄MXene导电薄膜的渗透驱动电子传输和厚度相关的微波吸收/屏蔽双重功能

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-07-01 DOI: 10.1039/d5nr01970b

Dong Wen, Xu Zhou, Qianqian Fan, Can Cui, Kang Fang, Ling Ding, Xiao ai Ye, Shihao Zheng, Zhaokun Jiang, Yanke Zhou, Daqiang Zhao, Gui-Gen Wang

{"title":"Ultrathin MXene Conductive Films with Percolation-Driven Electron Transport and Thickness-Dependent Microwave Absorption/Shielding Dual Functionality","authors":"Dong Wen, Xu Zhou, Qianqian Fan, Can Cui, Kang Fang, Ling Ding, Xiao ai Ye, Shihao Zheng, Zhaokun Jiang, Yanke Zhou, Daqiang Zhao, Gui-Gen Wang","doi":"10.1039/d5nr01970b","DOIUrl":"https://doi.org/10.1039/d5nr01970b","url":null,"abstract":"The microwave interaction of ultrathin Ti3C2Tx MXene films is governed by their nanosheet network-modulated conductivity. By integrating a transfer matrix model with the Drude model, this study reveals the dielectric response mechanisms of MXene films under microwave radiation, driven by nanosheet coverage (c) and thickness (t). For monolayer films, coverage-dependent conductivity transitions delineate two distinct regimes: (i) a discontinuous percolation regime (c<80%) dominated by intra-flake electron transport (εi/εr<1), resulting in high microwave transparency, and (ii) a metallic-like conduction regime (c>80%) where synergistic intra-/inter-flake hopping (εi/εr>1) enhances interfacial polarization and ohmic loss, enabling 27% maximum microwave absorption at a high sheet conductivity of ~0.001 S (c=93%). For multilayer continuous films, thickness dictates dual transport dynamics: sub-6.6 nm films exhibit surface/interface scattering-limited bulk conductivity (σ~3000 S·cm-1, τ>6 ps), while thicker films (t>6.6 nm) transition to bulk-like metallic conduction (σ∼13000 S·cm-1, τ<6 ps), achieving concurrent 48% microwave absorption at 6.6 nm and 19 dB shielding at 24 nm. The percolation-governed conductivity scaling and thickness-modulated electron transport establish design principles for optimizing MXene-based ultrathin electromagnetic functional materials in microwave absorption, shielding, and flexible sensing applications, bridging nanoscale structural engineering with macroscopic functionality.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"31 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144521502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation on Thyroglobulin and Myoglobin using graphene-enhanced Raman spectroscopy as a tool 用石墨烯增强拉曼光谱研究甲状腺球蛋白和肌红蛋白

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-07-01 DOI: 10.1039/d5nr00800j

ANAMIKA SHARMA, Venkata Ramanaiah Dantham

引用次数: 0