ACS Omega最新文献

{"title":"Repurposing the Insecticide Flufenerim, the Only Anti-Cryptococcus Compound Identified in the MMV Global Health Priority Box, as a Candidate for the Environmental Control of the Cryptococcosis Agents","authors":"Juliana Godoy,&nbsp;Iara Bastos de Andrade,&nbsp;Edinaldo Castro de Oliveira,&nbsp;Igor Avellar-Moura,&nbsp;Kamilla Xavier Gomes,&nbsp;Felipe Carvalho da Costa,&nbsp;Marcelo Kurgonas de Oliveira,&nbsp;Carlos Pelleschi Taborda,&nbsp;Allan Jefferson Guimarães,&nbsp;Rosely Maria Zancopé-Oliveira,&nbsp;Marcos Abreu Almeida,&nbsp;Susana Frases,&nbsp;Rodrigo Almeida-Paes","doi":"10.1021/acsomega.6c04207","DOIUrl":"https://doi.org/10.1021/acsomega.6c04207","url":null,"abstract":"<p><em>Cryptococcus neoformans</em> and <em>Cryptococcus gattii</em> are environmentalfungi thatcause cryptococcosis, a severe, life-threatening infection, particularlyin immunocompromised individuals. Current treatments are limited bytoxicity, restricted availability, and the emergence of resistance,highlighting the need for novel antifungal agents. Here, 240 compoundsfrom the Medicines for Malaria Venture (MMV) Global Health PriorityBox were screened for activity against these two species. Flufenerim,originally developed as an insecticide, was the only compound thatexhibited inhibitory activity at 1 μM (0.364 μg/mL). Minimuminhibitory concentrations ranged from 0.03 μg/mL to &gt;8 μg/mLacross 15 isolates, and the compound exhibited a predominantly fungistaticprofile, except for one <em>C. gattii</em> strain.At subinhibitory concentrations, flufenerim significantly reducedcapsule thickness in both species, melanization in <em>C. neoformans</em>, and urease production in <em>C. gattii</em>, without affecting phospholipase activity. <em>In silico</em> ADMET predictions indicated predicted toxicologicalrisks requiring further evaluation. Cytotoxicity assays further demonstratedthat the compound did not exhibit significant toxicity in murine andhuman macrophages, nor in human brain endothelial cells (HBECs). Exposureof <em>Galleria mellonella</em> larvae to flufenerimproduced sublethal physiological effects without mortality. Due tothe unfavorable ADMET profile, we evaluated whether this compoundcould be used for environmental control of fungal reservoirs. Tree-hollowsamples spiked with <em>C. neoformans</em> andtreated with flufenerim yielded fewer yeast colonies than untreatedcontrols when plated on Staib’s agar. These findings identifyflufenerim as a new anti-<em>Cryptococcus</em> compound and provide preliminary evidence supporting its potentialfor reducing <em>C. neoformans</em> recoveryfrom environmental substrates. However, the ecological complexityof <em>Cryptococcus</em> reservoirs and thepotential effects on nontarget microorganisms require extensive investigationbefore any environmental application can be considered.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"11 41","pages":"62717–62727"},"PeriodicalIF":5.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery of MYC/NSD3S Protein–Protein Interaction Negative Modulators with a Live Cell Nanoluciferase Protein-Fragment Complementation uHTS Assay","authors":"Sebastián Vera-Molina,&nbsp;Diego Acosta-Yanez,&nbsp;Ebonny Olivera,&nbsp;Esteban Romero-Vera,&nbsp;Carlos Farkas,&nbsp;Matías I. Hepp,&nbsp;Alexis Salas-Burgos,&nbsp;Yuhong Du,&nbsp;Valentina Gonzalez-Pecchi","doi":"10.1021/acsomega.6c03996","DOIUrl":"https://doi.org/10.1021/acsomega.6c03996","url":null,"abstract":"<p>Protein–protein interactions (PPIs) are centralto physiologicaland pathophysiological processes. Identifying PPI modulators is thefirst step toward the development of new treatments. c-MYC (MYC),a key oncogene, interacts with NSD3S, stabilizing its structure andenhancing the oncogenic effect. In this work, we developed the NanoPCAassay in live cells in a 1536-well uHTS format to monitor the MYC/NSD3SPPI. We validated the platform by screening 12,000 compounds. Theactions of several dose-dependent modulators were confirmed. Usingorthogonal assays (immunoprecipitation, MYC reporter, and viability),we identified ethoxysanguinarine and withaferin A as potential negativemodulators. Additionally, PPI in silico modeling and identificationof key interaction points (hotspots) were performed to understandhow the compounds may bind, revealing their potential ability to blockthe MYC/NSD3S PPI. These represent initial chemical tools that disruptthe MYC/NSD3S PPI signal in live cell assays and biochemical lysates,laying the foundation for targeted therapies against MYC/NSD3S-dependentcancers.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"11 41","pages":"62689–62699"},"PeriodicalIF":5.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary Metabolites from the Red Macroalga Sphaerococcus coronopifolius as Hit Candidates of Helicobacter pylori Purine Nucleoside Phosphorylase","authors":"Ana Micaela Camini,&nbsp;Maria Eduarda Delawi,&nbsp;Bruno Rampanelli Dahmer,&nbsp;Manuella Silva da Costa,&nbsp;Celso Miguel da Maia Alves,&nbsp;Joana Rita Martins da Silva,&nbsp;Rui Filipe Pinto Pedrosa,&nbsp;Jeferson Camargo de Lima,&nbsp;Luís Fernando Saraiva Macedo Timmers","doi":"10.1021/acsomega.6c05168","DOIUrl":"https://doi.org/10.1021/acsomega.6c05168","url":null,"abstract":"<p><em>Helicobacter pylori</em> is a major humanpathogen associated with gastric cancer and a growing global publichealth concern due to increasing antimicrobial resistance. As <em>H. pylori</em> lacks <em>de novo</em> purine biosynthesisand relies entirely on purine salvage for nucleotide production, purinenucleoside phosphorylase represents a rational antibacterial target.Natural products remain a valuable and largely underexplored sourceof structurally diverse scaffolds for the discovery of novel enzymeinhibitors, with marine organisms representing a rich yet underexploitedsource of such bioactive metabolites; however, the pharmacologicalexploration of this enzyme from natural sources remains limited. Inthis context, six terpenoids, including five brominated diterpenes,isolated from the red macroalga <em>Sphaerococcus coronopifolius</em> were screened against recombinant <em>H. pylori</em> PNP using a target-based biochemical approach. Two of the six compoundstested, bromosphaerol and sphaerodactylomelol, showed reproducibleinhibitory activity at 30 μM, reducing <em>H. pylori</em> PNP activity by 46.04 ± 4.70% and 39.39 ± 8.24%, respectively.Molecular docking predicted binding of both compounds within the active-sitepurine-binding region, with hydrophobic contacts involving Phe159and Leu206. Hydrogen bonds were predicted with the backbone carbonylof Ile178 for bromosphaerol and of Phe159 for sphaerodactylomelol.Molecular dynamics simulations (200 ns, three independent replicatesper system) showed that both ligands remained stably accommodatedwithin the predicted active-site binding pocket across all six monomersof the hexameric assembly, while root mean square deviation (RMSD)and root mean square fluctuation (RMSF) analyses indicated that theenzyme retained its global structural integrity throughout the simulations.Bromosphaerol exhibited a lower RMSD than the conformationally flexiblesphaerodactylomelol, reflecting differences in ligand dynamics withinthe binding pocket. Taken together, these findings provide initialbiochemical evidence that <em>S. coronopifolius</em> represents a source of secondary metabolites capable of interactingwith <em>H. pylori</em> PNP, and nominate bromosphaeroland sphaerodactylomelol as preliminary hits for future concentration–responsecharacterization.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"11 41","pages":"62973–62984"},"PeriodicalIF":5.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulating the Electronic Structure and Basal-Plane Adsorption of Janus CrSSe through Mechanochemical Activation","authors":"Juan Gomez Quispe,&nbsp;Pedro Alves da Silva Autreto","doi":"10.1021/acsomega.6c04409","DOIUrl":"https://doi.org/10.1021/acsomega.6c04409","url":null,"abstract":"<p>Mechanochemical activation offers a reversible and chemicallynoninvasiveroute to tune the basal-plane reactivity of two-dimensional catalysts.Here, spin-polarized density functional theory calculations are employedto investigate strain- and curvature-engineered Janus CrSSe for thehydrogen evolution reaction, comparing H* adsorption on the CrSSe-Sand CrSSe-Se surfaces and extending the analysis to zigzag CrSSe-NT(<em>n</em>,0) nanotubes. HER-relevant H adsorption thermodynamicsare evaluated within the computational hydrogen electrode frameworkusing the adsorption free energy, Δ<em>G</em>_ads, and the H* binding energy, <em>E</em>_b. Pristine2D CrSSe exhibits strongly non-thermo-neutral H* adsorption with apronounced polarity dependence. In-plane strain markedly reconstructsthe electronic structure, with biaxial tension inducing metallicityand spin polarization and driving Δ<em>G</em>_ads close to thermo-neutral values. Curvature introduces an additionalpolarity-dependent degree of freedom: S-terminated nanotubes exhibitspin-polarized metallic behavior, whereas Se-terminated nanotubesremain semiconducting and converge to zero-net-spin states. A pronouncedstructural–magnetic crossover between CrSSe-NT-S(20,0) and(21,0) is accompanied by an abrupt change in H* binding, revealinga direct coupling between curvature, magnetism, and chemisorption.Moderate axial tensile strain of 3–5% further tunes this curvature-dependentadsorption response and brings Δ<em>G</em>_ads closer to the thermo-neutral regime over a broad range of nanotubediameters. Overall, these results establish strain, curvature, andJanus polarity as coupled physical descriptors for controlling theelectronic, magnetic, and hydrogen adsorption properties of CrSSenanostructures.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"11 41","pages":"62744–62755"},"PeriodicalIF":5.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma-Enhanced Multilayer Coatings on Metal Bipolar Plates for Corrosion Resistance and High Electrical Conductivity","authors":"Prawal P. K. Agarwal,&nbsp;Benjamin Meekins,&nbsp;Mruthunjaya Uddi","doi":"10.1021/acsomega.6c06464","DOIUrl":"https://doi.org/10.1021/acsomega.6c06464","url":null,"abstract":"<p>Metal bipolar plates are central to lowering the costand weightof proton exchange membrane fuel cell (PEMFC) stacks, yet their long-termuse is limited by aggressive corrosion in the acidic, humid, low-pHcathode environment. Multilayer protective coatings combining adhesion-promotingmetal interlayers with chemically inert graphitic carbon are widelyregarded as a promising solution, but they have historically beendeposited slowly and from precursors such as titanium tetrachloridethat are difficult to scale safely. Here, we report the design andoperation of a showerhead plasma-enhanced chemical vapor deposition(PECVD) reactor that deposits Ti/TiC_<em>x</em>/amorphous-carbon(a-C) multilayer coatings on 304 stainless steel using the comparativelysafe titanium isopropoxide (TiPO) precursor in combination with ahydrogen plasma. Both continuous radio frequency (RF) and nanosecond-pulsedglow discharges were tested at 10 W and at substrate temperaturesup to 300 °C. Cross-sectional scanning electron microscopy (SEM),energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD),and Raman scattering confirm uniform, pinhole-free multilayers inwhich Ti is reduced from TiPO by atomic hydrogen and the carbon toplayer is sp²-rich and graphitic. Carbon deposition ratesof 200–237 nm min^–1 were obtained, matchingor exceeding the best values reported in the literature. A coupledplasma kinetics and showerhead transport model rationalizes theserates, the distinct microstructures obtained under continuous andnanosecond-pulsed excitation, and the measured coating uniformity.The best carbon coatings reach interfacial contact resistance (ICR)values of 5.4–13.5 mΩ·cm² at 1.10 MPa,with the lowest well below the 2025 U.S. Department of Energy (DOE)target of 10 mΩ·cm². The coatings showed nodetectable Raman or morphological degradation after accelerated thermalcycling between 30 and 100 °C in pH 3 H₂SO₄, demonstrating their potential as a fast, safe, and scalable coatingroute for next-generation PEMFC bipolar plates.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"11 41","pages":"63213–63230"},"PeriodicalIF":5.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introducing 2-Thioxocoumarins as a New Class of Photosensitizers for Antimicrobial Photodynamic Therapy","authors":"Javier Ordóñez-Hernández,&nbsp;Abel Jaume-Masferrer,&nbsp;Jordi Hernando,&nbsp;Marc Martínez-Miguel,&nbsp;Claire Brazzi,&nbsp;Elies Molins,&nbsp;Rosario Núñez","doi":"10.1021/acsomega.6c07980","DOIUrl":"https://doi.org/10.1021/acsomega.6c07980","url":null,"abstract":"<p>Antimicrobial photodynamic therapy (aPDT) has gainedincreasingattention as an alternative approach to combat bacterial resistance,although the development of efficient visible-light photosensitizers(PSs) remains a major challenge. Despite the extensive investigationof coumarin derivatives for photodynamic applications, 2-thioxocoumarinshave not previously been explored for aPDT. Herein, we introduce 2-thioxocoumarinsas a new class of photosensitizers for aPDT through the rational designand synthesis of four derivatives (<strong>TCM-1</strong>–<strong>TCM-4</strong>). Thionation, combined with strategic bromination, modulatedthe photophysical and photochemical properties of the coumarin scaffold,promoting visible-light absorption and efficient generation of reactiveoxygen species (ROS) via both Type I and Type II photochemical pathways.Biological evaluation identified the monobrominated derivative <strong>TCM-2</strong> as the lead photosensitizer, exhibiting potent light-inducedantibacterial activity against methicillin-sensitive and methicillin-resistant <em>Staphylococcus aureus</em> with minimum inhibitory concentrationsof 4–8 μM and no detectable dark toxicity. Although thetribrominated derivatives (<strong>TCM-3</strong>–<strong>TCM-4</strong>) exhibited enhanced Type I ROS generation, this was not accompaniedby a proportional increase in photodynamic antibacterial activity,highlighting that efficient photodynamic inactivation depends notonly on ROS generation but also on molecular properties governingbacterial interactions. These findings establish 2-thioxocoumarinsas promising antimicrobial PSs for surface disinfection in healthcaresettings and as a valuable molecular scaffold for the developmentof next-generation antimicrobial photosensitizers.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"11 41","pages":"63755–63767"},"PeriodicalIF":5.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gate-Tunable Single Ag–rGO FET Platform for Room-Temperature Trigas Detection with a CMOS-Compatible PWM Readout Interface","authors":"Mayank Kohli,&nbsp;Nimisha,&nbsp;Swapnil Sharma,&nbsp;Santanab Majumder,&nbsp;Gourab Dutta,&nbsp;Tarun Kanti Bhattacharyya","doi":"10.1021/acsomega.6c05753","DOIUrl":"https://doi.org/10.1021/acsomega.6c05753","url":null,"abstract":"<p>Room-temperaturegas sensing requires high sensitivityand selectivity,which FET-based architectures achieve through gate-controlled modulationof surface potential and carrier transport, enabling tunable and efficientchemical transduction. In this work, we introduce a smart trigas sensorcapable of selectively detecting three target gases─acetone,formaldehyde, and ammonia at room temperature using a single FET bysimply tuning the gate voltage. By leveraging gate-induced modulation,this study demonstrates dynamic control over the interaction betweengas molecules and the silver-decorated Reduced Graphene Oxide (Ag-rGO)channel-based gas FET sensor, enabling the individual and selectivedetection of three distinct gases using the single device. Furthermore,the proposed platform demonstrates distinct cross-sensitivity characteristics,wherein gate-bias modulation enables selective discrimination betweenformaldehyde, acetone, and ammonia under mixed-gas environments. Thedevice exhibits high detection capability with experimentally estimatedlimits of detection (LOD) of 158 ppb for acetone, 31 ppb for formaldehyde,and 36 ppb for ammonia, highlighting its potential for low-concentration,room-temperature multigas sensing applications. Beyond material anddevice-level innovation, a TSMC 180 nm 3.3 V CMOS readout circuitis designed and simulated in Cadence Virtuoso, featuring analoguefront-end design for interfacing the proposed gas sensor with a low-powerembedded system via PWM signals. The proposed multigas sensor platformand the designed and simulated readout circuit establish a compactand low-power sensing framework, providing a foundation for futurestudies on breath biomarker analysis and disease-detection applications.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"11 41","pages":"63075–63083"},"PeriodicalIF":5.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149222034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spinel Interphase Modulation in Ba/Al2O3: A Strategy to Enhance NOx Storage Capacity and Durability of NSR Catalysts","authors":"Jinxiu Xiao,&nbsp;Qian Chen,&nbsp;Dezhi Ren,&nbsp;Chengxiong Wang,&nbsp;Xiang Wu,&nbsp;Junchen Du,&nbsp;Yunkun Zhao","doi":"10.1021/acsomega.6c07225","DOIUrl":"https://doi.org/10.1021/acsomega.6c07225","url":null,"abstract":"<p>NO_<em>x</em> storage reduction (NSR) technologyhas obvious advantages in NO_<em>x</em> purificationof lean-burn gasoline engines, but its application is limited by catalystdeactivation induced by hydrothermal aging. In this work, spinel-structuredMeAl₂O₄ (Me = Mg, Ba, Ni) were introduced intothe Ba/Al₂O₃ system via an impregnation–calcinationmethod. The composition and structure of spinel-modified Ba/Al₂O₃ samples were characterized by XRF, XRD, SEM,H₂-TPR, and N₂ physical adsorption–desorptiontechniques. The effect of spinel interphase on the NO_<em>x</em> storage capacity and desorption performance of Ba/Al₂O₃ was investigated by coupling the oxidation functionof Pt/Al₂O₃. It was revealed that the spinelinterphase as physical barriers and chemical-bonding medium inhibitedthe solid-phase diffusion of Ba species into the γ-Al₂O₃ lattice, weakened the interaction between Ba speciesand γ-Al₂O₃, suppressed the formationof BaAl₂O₄ spinel, stabilized the active Baspecies, and markedly enhanced hydrothermal stability and NO_<em>x</em> storage capacity of the catalysts. When BaAl₂O₄ was introduced as the interface control layer,the NO_<em>x</em> storage capacity of the aged catalystwas 3.78–13.60 times that of the Ba/Al₂O₃ catalyst at the same temperature. These results provide a novelstrategy for designing high-performance NSR catalysts.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"11 41","pages":"63554–63562"},"PeriodicalIF":5.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biogenic Magnetosomes as Magnetically Recoverable Catalysts for Benzyl Alcohol Oxidation","authors":"Josh Bond,&nbsp;Marcia Mendes de Carvalho,&nbsp;Amin Osatiashtiani,&nbsp;Tim William Overton,&nbsp;Oliver Brooks,&nbsp;Vesna Najdanovic-Visak,&nbsp;Alfred Fernandez-Castane","doi":"10.1021/acsomega.6c07960","DOIUrl":"https://doi.org/10.1021/acsomega.6c07960","url":null,"abstract":"<p>Biogenic magnetosomesare intracellular single-domain magneticnanoparticles (MNPs) produced by <em>Magnetospirillum gryphiswaldense</em> MSR1, consisting of crystalline magnetite (Fe₃O₄) encapsulated within an organic membrane. Despite their controlledstructure and widespread study in biomedical and magnetic applications,their use in catalysis has not been explored. Here, magnetosomes aredemonstrated for the first time as heterogeneous catalysts for benzylalcohol oxidation using hydrogen peroxide. Under aqueous batch conditions,catalytic performance was tested, varying catalyst loading and temperature.Among the loadings tested, the highest conversion was achieved using5.2 mol % Fe₃O₄ equivalent, reaching 64 ±4% after 24 h with 36 ± 5% benzaldehyde selectivity. At approximatelymatched Fe₃O₄ contents, this performance wasbroadly comparable to commercial Fe₃O₄, whichproduced 72 ± 2% conversion and 38 ± 3% selectivity. Temperaturescreening of magnetosome catalysts increased conversion up to 75 ±11% at 85 °C with 30 ± 4% benzaldehyde selectivity. Meanwhilemilder conditions improved selectivity to 43 ± 2% at the expenseof lower conversion, reflecting the expected conversion/selectivitytrade-offs seen in wider iron oxide-catalyzed peroxide systems. Catalyticrecyclability was demonstrated over five reaction cycles, where magneticrecovery enabled the spent mixture to be removed and replaced withoutcentrifugation or filtration. During these cycles conversion decreasedonly modestly from 71 ± 5% to 65 ± 4% with selectivity remainingbetween 33 and 38%. Overall, this work demonstrates that biogenicmagnetosomes can function as catalytic materials and expands the potentialapplications of magnetotactic bacteria-derived nanostructures.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"11 41","pages":"63744–63754"},"PeriodicalIF":5.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lightweight Soft X-ray Shielding in β-Ga2O3-Coated Natural Wood Evaluated Using a Ga2O3 Schottky Barrier Diode Detector","authors":"Jiwon Kwak,&nbsp;Sunjae Kim,&nbsp;Soon-il Kwon,&nbsp;Heejoong Ryou,&nbsp;Dowon Lee,&nbsp;Woo-Min Cho,&nbsp;Hyun-Ung Oh,&nbsp;Jin-Ho Kim,&nbsp;Ji-Hyeon Park,&nbsp;Dae-Woo Jeon,&nbsp;Wan Sik Hwang","doi":"10.1021/acsomega.6c05989","DOIUrl":"https://doi.org/10.1021/acsomega.6c05989","url":null,"abstract":"<p>Soft X-ray shielding under stringent mass constraintsis increasinglyimportant for near-space aviation, small satellite platforms, andother weight-sensitive aerospace systems. Natural wood is an attractivelightweight and biobased structural core; however, its attenuationcapability at keV range photon energies is strongly governed by bulkdensity. In this study, we enhance the soft X-ray shielding performanceof natural wood by introducing a spray-deposited β-Ga₂O₃ particle-containing coating formed with a binder matrix.The transmitted X-ray intensity was quantified using a β-Ga₂O₃ Schottky barrier diode detector under 5.0 kVpirradiation. Three wood species with different bulk densities─cedar,oak, and birch, with densities of 0.289, 0.697, and 0.913 g·cm^–3, respectively─were prepared with a fixed thicknessof 1 mm. Cross-sectional scanning electron microscopy and energy-dispersiveX-ray spectroscopy reveal the formation of an approximately 100 μmthick near-surface wood–inorganic hybrid region, in which Gaand O signals coexist within the coated wood structure. Compared withuncoated wood, the β-Ga₂O₃-containingcoating consistently reduces the transmitted X-ray-induced currentfor all wood species, leading to improved shielding efficiency. Notably,cedar, the lowest density wood, exhibits the largest relative improvementafter coating, indicating that a thin inorganic coating can effectivelycompensate for the intrinsically limited attenuation of lightweightwood cores while imposing only a modest mass penalty. These resultsdemonstrate a practical wood–inorganic composite architecturefor lightweight soft X-ray shielding and suggest that low-densitywood substrates can provide a favorable mass–performance balancewhen combined with β-Ga₂O₃-based surfacehybridization.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"11 41","pages":"63096–63100"},"PeriodicalIF":5.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149222005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}