ACS Omega最新文献

{"title":"Scale-Up Synthesis of Porous Silicon Structures by Rotary Magnesiothermic Reduction of Silica for Advanced Energy Storage Materials","authors":"JeongWoo Bae,&nbsp;, ,&nbsp;ChanSik Son,&nbsp;, ,&nbsp;Jae Wook Suh,&nbsp;, ,&nbsp;SeEun Park,&nbsp;, ,&nbsp;Seung Hyeok Chu,&nbsp;, ,&nbsp;Murugesan Karuppaiah,&nbsp;, ,&nbsp;Minah Lee,&nbsp;, ,&nbsp;Jae-Bong Kim,&nbsp;, ,&nbsp;Jindo Kim,&nbsp;, and ,&nbsp;Jung Kyoo Lee*,&nbsp;","doi":"10.1021/acsomega.5c06589","DOIUrl":"https://doi.org/10.1021/acsomega.5c06589","url":null,"abstract":"<p >A 1L-scale dynamic magnesiothermic reduction (DMR) of nonporous silica (1.8 μm in diameter) was conducted using a rotary reactor system to produce porous silicon (pSi) particles for lithium-ion battery (LIB) anodes. The effects of the NaCl (heat scavenger)-to-silica weight ratio (0.8, 3.0, 5.0, and 10.0) were systematically investigated in terms of (i) exothermic reduction heats (monitored in situ and estimated by enthalpy balance), (ii) porosity development in the resulting pSi particles, and (iii) electrochemical performance of the pSi/C composites, benchmarked against conventional silicon nanoparticles (SiNP, &lt;50 nm)/C. When the NaCl/silica weight ratio was ≥5, no significant temperature spikes were observed due to effective dissipation of the exothermic heat, resulting in highly porous pSi particles. Thanks to their favorable structure, both bare pSi-1 particles (synthesized at a NaCl/silica ratio of 10.0) and the corresponding pSi-1/C composites exhibited superior cycling performance compared to bare SiNP and SiNP/C composites, respectively. In particular, the pSi/C composites derived from highly porous pSi showed enhanced cycling stability, retaining over 90.9% of their initial capacity after 270 cycles at a current density of 500 mA g^–1. It also demonstrated excellent rate capability, full-cell performance, and structural robustness, underscoring its potential as a high-capacity LIB anode material. These findings highlight the DMR of silica as a scalable and effective process for the mass production of porous silicon particles, offering a promising pathway for next-generation high-performance LIB anodes.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 41","pages":"48670–48683"},"PeriodicalIF":4.3,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.5c06589","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathways of Conversion of Middle Distillate Hydrocarbons in Deep Catalytic Cracking to Produce Light Olefins","authors":"Valentin R. Atlasov*,&nbsp;, ,&nbsp;Timur A. Palankoev,&nbsp;, and ,&nbsp;Konstantin I. Dement’ev,&nbsp;","doi":"10.1021/acsomega.5c06758","DOIUrl":"https://doi.org/10.1021/acsomega.5c06758","url":null,"abstract":"<p >The relevance of cracking diesel fractions into light olefins is determined by the strategic need to transition from a fuel-based refinery model to a petrochemical-based refinery model, growing global demand for polymers, and environmental sustainability requirements. The aim of this work is to explore the possibility of the selective production of light olefins from diesel fraction hydrocarbons. The pathways of high-temperature catalytic cracking of individual hydrocarbons that simulate the composition of diesel fractions over catalysts containing zeolites of various types (Y, ZSM-5, and β) have been studied. Maximum selectivity for light olefins in the cracking of aliphatic and alkylaromatic hydrocarbons was achieved using catalysts with the lowest activity in hydrogen transfer reactions. Based on the cracking of tetraline, it was shown that at temperatures above 625 °C, the kinetic control of the reactions under deep cracking conditions is predominant, whereas at lower temperatures, the selectivity is controlled by thermodynamics. Light olefin selectivity in the case of substituted aromatic and naphthenic hydrocarbons strongly depends on the porous structure of the catalyst. Conversion pathways for different classes of hydrocarbons under deep catalytic cracking conditions are proposed.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 41","pages":"48761–48772"},"PeriodicalIF":4.3,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.5c06758","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Situ Reduction Fabricated Pt-Mediated Bi2WO6/g-C3N4 Heterojunction with Unconventional Z-Scheme Charge Transfer for Enhanced Photocatalysis and Hydrogen Evolution","authors":"Nur Syamimi Adzis,&nbsp;, ,&nbsp;Nur Hidayatul Syazwani Suhaimi,&nbsp;, ,&nbsp;Rahil Azhar,&nbsp;, ,&nbsp;Suriati Sufian,&nbsp;, ,&nbsp;Mahidin Mahidin,&nbsp;, ,&nbsp;Azhar Ali Haidry,&nbsp;, ,&nbsp;Mohamad Fariz Mohamad Taib,&nbsp;, ,&nbsp;Yee Hui Robin Chang,&nbsp;, ,&nbsp;Wan Izhan Nawawi Wan Ismail*,&nbsp;, and ,&nbsp;Mohd Azlan Mohd Ishak,&nbsp;","doi":"10.1021/acsomega.5c04112","DOIUrl":"https://doi.org/10.1021/acsomega.5c04112","url":null,"abstract":"<p >A novel Pt-mediated Z-scheme heterojunction photocatalyst, Pt-Bi₂WO₆/g-C₃N₄ (Pt-BWO/g-CN), was synthesized via an in situ reduction strategy, enabling precise Pt positioning as an electron mediator between BWO and g-CN. Structural and morphological analyses (FESEM, HRTEM, and BET) confirmed nanoscale integration, uniform Pt dispersion, and high surface area. X-ray photoelectron spectroscopy (XPS) revealed binding energy shifts indicative of efficient interfacial charge transfer, while UV–vis diffuse reflectance spectroscopy (DRS) and Mott–Schottky analyses confirmed favorable band alignment consistent with a direct Z-scheme pathway. Photoluminescence (PL) and photoelectrochemical measurements demonstrated suppressed electron–hole recombination and enhanced charge separation. Electron paramagnetic resonance (EPR) provided compelling mechanistic evidence: DMPO-trapped spectra detected abundant ^•OH and ^•O^2– radicals under light irradiation, TEMP-trapped spectra confirmed ¹O₂ formation, and intrinsic oxygen vacancies (<i>g</i> ≈ 2.003) were observed even in the dark, decreasing upon illumination, supporting defect-assisted charge transfer. The optimized Pt-BWO/g-CN achieved complete RhB degradation and 85% RR4 removal within 60 min under visible light, alongside a hydrogen generation rate of 5364.96 μmol g^–1 h^–1 (STH efficiency of 3.4% and AQY of 3.5%). Radical scavenging identified h⁺ and ^•O₂^– as the dominant active species. This work demonstrates a scalable route to high-performance Z-scheme photocatalysts with dual capability in pollutant degradation and solar hydrogen generation, underpinned by direct spectroscopic validation of the charge transfer pathway.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 41","pages":"48061–48079"},"PeriodicalIF":4.3,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.5c04112","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Circulating Liposomes Codelivering Amphotericin B and Retinoic Acid for Cutaneous Leishmaniasis Treatment","authors":"Thais T. Santos,&nbsp;, ,&nbsp;Eduardo B. Lages,&nbsp;, ,&nbsp;Tiago N. Q. Ricotta,&nbsp;, ,&nbsp;Leandro G. de Oliveira,&nbsp;, ,&nbsp;Guilherme S. Ramos,&nbsp;, ,&nbsp;Julie Burlot,&nbsp;, ,&nbsp;Sonia Abreu,&nbsp;, ,&nbsp;Pierre Chaminade,&nbsp;, ,&nbsp;François-Xavier Legrand,&nbsp;, ,&nbsp;Pauline Tran,&nbsp;, ,&nbsp;Claudine Deloménie,&nbsp;, ,&nbsp;Virgínia M. R. Vallejos,&nbsp;, ,&nbsp;Doumet Georges Helou,&nbsp;, ,&nbsp;Raquel M. de Almeida,&nbsp;, ,&nbsp;Celso M. Queiroz-Junior,&nbsp;, ,&nbsp;Gabriel B. M. Teobaldo,&nbsp;, ,&nbsp;Cristiano L. P. de Oliveira,&nbsp;, ,&nbsp;Lucas A. M. Ferreira,&nbsp;, ,&nbsp;Marta M. G. Aguiar*,&nbsp;, ,&nbsp;Sébastien Pomel*,&nbsp;, and ,&nbsp;Frédéric Frézard*,&nbsp;","doi":"10.1021/acsomega.5c06156","DOIUrl":"https://doi.org/10.1021/acsomega.5c06156","url":null,"abstract":"<p >Leishmaniasis is a neglected tropical disease that mainly affects socially vulnerable populations. It is caused by various <i>Leishmania</i> species, and manifests primarily as cutaneous (CL) or visceral leishmaniasis (VL). AmBisome, a commercial formulation of amphotericin B (AmB) with conventional liposomes, is the most effective for VL treatment, but its efficacy is limited in some CL cases and immunocompromised patients. This work evaluated a new PEGylated liposomal formulation (LAmB-RA) coencapsulating AmB and retinoic acid (RA), as an immunomodulator, for CL treatment. LAmB-RA displayed a mean size of 125 nm, a polydispersity index &lt;0.2, and high encapsulation efficiencies for AmB (97.1%) and RA (94.7%). Although SAXS analysis indicates that RA did not induce major structural rearrangements in the liposomal bilayer, comparison of circular dichroism spectra between LAmB-RA and the liposomal AmB formulation without RA (LAmB) revealed slightly different aggregated states of AmB. In addition, LAmB-RA showed a significantly reduced hemolytic activity, compared to LAmB. Pharmacokinetic analysis of the PEGylated formulations showed higher <i>C</i>_max and prolonged plasma exposure of AmB compared to AmBisome. In Leishmania <i>major</i>-infected mice, LAmB-RA significantly reduced lesion size and parasite burden (99%) versus untreated control. In the <i>Leishmania amazonensis</i> model, it markedly inhibited lesion progression and was the only treatment to significantly reduce parasite load in the spleen (by 60%). Additionally, LAmB-RA promoted an increase in the IFN-γ/IL-10 ratio in antigen-stimulated splenocytes compared to LAmB, indicating a Th1-skewed immune response. These results support LAmB-RA as a promising therapeutic strategy for CL, combining prolonged circulation and enhanced efficacy.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 41","pages":"48514–48530"},"PeriodicalIF":4.3,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.5c06156","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ni-Doped SnO Microplates for Carbon Monoxide Gas Detection","authors":"Giuliana Giulietti,&nbsp;, ,&nbsp;Miguel D. Sanchez,&nbsp;, ,&nbsp;Elson Longo,&nbsp;, ,&nbsp;Marcelo Assis,&nbsp;, ,&nbsp;Anderson Albuquerque,&nbsp;, ,&nbsp;Julio R. Sambrano*,&nbsp;, ,&nbsp;Miguel A. Ponce,&nbsp;, and ,&nbsp;Paula M. Desimone,&nbsp;","doi":"10.1021/acsomega.5c06392","DOIUrl":"https://doi.org/10.1021/acsomega.5c06392","url":null,"abstract":"<p >Undoped and Ni-doped SnO were synthesized using a microwave-assisted hydrothermal method to analyze the influence of Ni-doped SnO nanostructures on CO detection. The scanning electron microscopy (SEM) analysis revealed a predominantly tetragonal SnO phase, with a minor proportion of the tetragonal SnO₂ phase. X-ray photoelectron spectroscopy (XPS) confirmed the SnO phase without the NiO_<i>x</i> phase on the microplate surfaces. The images showed micrometric plates with SnO (001) surfaces. The presence of Ni led to an increase in the carrier concentrations, resulting in enhanced conductivity. Additionally, density functional theory (DFT) calculations indicated that Ni doping in the outermost layer significantly enhanced CO affinity via carbon coordination, while oxygen-bound configurations became unstable. Electrical measurements showed a slight decrease in the activation energy (<i>E</i>_a) for the Ni-doped sample under a reductive atmosphere. This behavior facilitates the use of this material at room temperatures, which is technologically desirable for CO sensor devices.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 41","pages":"48603–48613"},"PeriodicalIF":4.3,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.5c06392","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solid-Phase Synthesis of Guanine Derivatives with Four Diversity Elements via AgNO3-Mediated Guanidine Formation","authors":"Jimin Moon,&nbsp;, ,&nbsp;Jimin Lee,&nbsp;, ,&nbsp;Hyojin Lee,&nbsp;, ,&nbsp;Geonho Yoon,&nbsp;, and ,&nbsp;Taeho Lee*,&nbsp;","doi":"10.1021/acsomega.5c08443","DOIUrl":"https://doi.org/10.1021/acsomega.5c08443","url":null,"abstract":"<p >We constructed a guanine derivative library with four diversities through efficient solid-phase synthesis. In this reaction, thiourea was transformed into guanidine through a guanylation reaction using AgNO₃, and the guanine core was synthesized by cyclization using a base. After oxidation using <i>m</i>CPBA, several nucleophiles were substituted to construct 36 derivative libraries through solid-phase synthesis. The reaction involved 7 steps in total, showing a good yield of over 57–82%, but it also showed a difference in cyclization reaction selectivity between solid-phase synthesis and solvent-phase synthesis. We will use the synthesized chemical library to find hit compounds for various diseases.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 41","pages":"49183–49191"},"PeriodicalIF":4.3,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.5c08443","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment of a Modified Ferric Chloride-Induced Canine Superficial Femoral Artery Thrombosis Model","authors":"Wang Song,&nbsp;, ,&nbsp;Yingwen Wang,&nbsp;, ,&nbsp;Shuting Li,&nbsp;, ,&nbsp;Chunmei Long,&nbsp;, ,&nbsp;Xiang Han,&nbsp;, ,&nbsp;Xingqi Fang,&nbsp;, ,&nbsp;Zhen Li,&nbsp;, ,&nbsp;Yuwei Yang,&nbsp;, ,&nbsp;Shihao Zhu,&nbsp;, ,&nbsp;Xuanyin Chen,&nbsp;, ,&nbsp;Qi Wang,&nbsp;, ,&nbsp;Baolai Zhang,&nbsp;, and ,&nbsp;Li Lu*,&nbsp;","doi":"10.1021/acsomega.5c05177","DOIUrl":"https://doi.org/10.1021/acsomega.5c05177","url":null,"abstract":"<p >Ferric chloride (FeCl₃) is a common agent for inducing thrombosis in laboratory animals. However, there is no sufficient data regarding the conditions of model preparation in dogs. We aimed to identify the optimal concentration and solvent of FeCl₃ for inducing canine superficial femoral artery thrombosis. We applied 30, 40, or 50% FeCl₃ in 1 M hydrochloric acid or water topically on the superficial femoral artery for 30 min to induce thrombosis, respectively, with the distal end of the exposed artery clipped for 15 min. Then the thrombus size and blood flow were assessed by the High-Resolution Ultrasonic Photoacoustic Multimode Imaging System, and pathological changes were evaluated with HE staining. Regardless of the concentration or solvent, FeCl₃ solutions successfully induced stable and dense thrombi. At day 28, 30% FeCl₃ in 1 M HCl demonstrated greater peak systolic velocity (PSV) ratios of normal and recanalization rates than 40% FeCl₃ in 1 M HCl. Except for day 14, 40% FeCl₃ in H₂O had lower PSV ratios and recanalization rates compared to 50% FeCl₃ in H₂O. The 40% FeCl₃ in H₂O demonstrated greater blood flow recovery than the 40% FeCl₃ in 1 M HCl. Compared to the water solution, the acidic solution caused more pronounced endothelial cell damage, with no differences between varying concentrations in the same solvent. FeCl₃ application combined with blood flow blockage effectively induced stable thrombi in the superficial femoral arteries of dogs. Hydrochloric acid solutions demonstrated better thrombus formation efficacy than water.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 41","pages":"48282–48292"},"PeriodicalIF":4.3,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.5c05177","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isoconversional Kinetic Analysis and ANN-Based Prediction of Metformin Pyrolysis for Sustainable Waste Management","authors":"Ramesh Potnuri,&nbsp;, ,&nbsp;Maheswata Lenka,&nbsp;, ,&nbsp;Chinta Sankar Rao*,&nbsp;, and ,&nbsp;Harshini Dasari*,&nbsp;","doi":"10.1021/acsomega.5c03868","DOIUrl":"https://doi.org/10.1021/acsomega.5c03868","url":null,"abstract":"<p >Pharmaceutical waste poses a growing environmental concern due to its persistence and potential ecological impacts, necessitating effective and sustainable management strategies. This study investigates the pyrolysis of metformin as a means to valorize pharmaceutical waste within a circular economy framework. Pyrolysis experiments conducted on 500 mg of metformin demonstrated the formation of liquid-phase products, characterized by GC–MS, which revealed a high concentration of the active pharmaceutical ingredient (API) alongside carbonaceous, nitro, and acidic compounds. Comprehensive thermogravimetric analyses at heating rates of 10, 20, 30, and 40 °C/min were performed to evaluate the thermal decomposition behavior. Kinetic parameters were determined using four isoconversional methods, namely KAS, FWO, Starink, and FRD, yielding average activation energies of 101.4, 105.8, 101.4, and 111.1 kJ/mol, respectively. Thermodynamic parameters (Δ<i>G</i>, Δ<i>H</i>, and Δ<i>S</i>) were also calculated to gain further insights into the decomposition process. Additionally, an ANN model was developed using temperature and heating rate as inputs to predict mass loss, achieving accurate estimations with an optimized architecture comprising two hidden layers. GC–MS analysis of the pyrolysis liquid identified a high concentration of the API, along with carbonaceous, nitro, and acidic compounds. These findings highlight the potential for API recovery and reuse, as well as the valorization of byproducts for energy or chemical synthesis. The potential recovery of APIs for reuse and the utilization of byproducts as fuels or chemical precursors underscore pyrolysis as a promising route for sustainable pharmaceutical waste management and circular economy integration.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 41","pages":"48019–48033"},"PeriodicalIF":4.3,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.5c03868","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidiabetic Activity and Inhibitory Effects of Derivatives of Advanced Aminoguanidine Glycation","authors":"Patrícia de Albuquerque Sarmento,&nbsp;, ,&nbsp;Andressa Letícia Lopes da Silva,&nbsp;, ,&nbsp;Edeildo Ferreira da Silva-Júnior,&nbsp;, ,&nbsp;Elita Scio,&nbsp;, ,&nbsp;Danielle Maria de Oliveira Aragão,&nbsp;, ,&nbsp;Êurica Adélia Nogueira Ribeiro,&nbsp;, ,&nbsp;Érica Erlanny da Silva Rodrigues,&nbsp;, ,&nbsp;Pedro Gregório Vieira Aquino,&nbsp;, ,&nbsp;Bárbara Viviana de Oliveira Santos,&nbsp;, ,&nbsp;Antônio Euzébio Goulart Santana,&nbsp;, ,&nbsp;Aline Cavalcanti de Queiroz,&nbsp;, ,&nbsp;Magna Suzana Alexandre-Moreira,&nbsp;, ,&nbsp;Henrique Douglas Melo Coutinho*,&nbsp;, and ,&nbsp;João Xavier de Araújo Júnior*,&nbsp;","doi":"10.1021/acsomega.5c01940","DOIUrl":"https://doi.org/10.1021/acsomega.5c01940","url":null,"abstract":"<p >Aminoguanidine is a drug that prevents the formation of AGEs by reacting with initial glycation products and is effective in improving proteinuria and vessel elasticity, preventing diabetic retinopathy, and treating patients with diabetic nephropathy. Structural modifications of this molecule were carried out, and 19 derivatives were studied to present a potential hypoglycemic and antiglicante effect, preventing such complications for diabetics. For this purpose, an in vitro cytotoxicity test was initially carried out by colorimetric assay with MTT [3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium], in macrophages of the J774 lineage. The AGEs were produced in vitro from the junction of glucose with bovine serum albumin and tested for evaluation of the antiglicante activity with reading in a fluorescence spectrophotometer. Derivatives with the best in vitro response were submitted to in vivo acute toxicity tests with Wistar rats and later evaluation of their antidiabetic and antiglycant potential in rats with streptozotocin-induced diabetes. After euthanasia, the heart, kidney, liver, and pancreas were removed for histopathological examination, and the blood for blood count and glycated hemoglobin, glucose, insulin, triglycerides, total cholesterol, HDL cholesterol, serum albumin, fructosamine, TGO, TGP, and GGT were collected. It is possible to conclude that the studied derivatives have the potential for the production of a drug that can be produced with them or associated with them and that is capable of reducing the glycemic indices and, at the same time, having an antiglicant action protecting individuals from macro- and microvascular complications.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 41","pages":"47914–47927"},"PeriodicalIF":4.3,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.5c01940","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Impact of Polyamide Nanofibrous Material Areal Weight on Lacticaseibacillus rhamnosus Biofilm Formation and Resistance to Storage Conditions and Contamination","authors":"Vaclav Peroutka*,&nbsp;, ,&nbsp;Marta Stindlova,&nbsp;, ,&nbsp;Vera Jencova,&nbsp;, ,&nbsp;Vera Lacinova,&nbsp;, ,&nbsp;Jana Jiresova,&nbsp;, ,&nbsp;Katerina Demnerova,&nbsp;, and ,&nbsp;Simona Lencova*,&nbsp;","doi":"10.1021/acsomega.5c01042","DOIUrl":"https://doi.org/10.1021/acsomega.5c01042","url":null,"abstract":"<p >Probiotic biofilms are considered the fourth most advanced generation of probiotics. To maximize the benefits of probiotic biofilms, suitable carriers ensuring bacterial viability during storage are being sought. The use of nanofibrous platforms is beginning to appear as one of the most promising approaches. We investigated the influence of three polyamide (PA) nanofibrous materials with different areal weights (5, 11, 27 g/m²) and the resulting morphological properties on the biofilm formation of <i>Lacticaseibacillus rhamnosus</i> ATCC 9595 and its tolerance to various conditions. PA promoted biofilm formation more than the reference material, polystyrene. PA’s areal weight influenced the biofilm biomass amount, phenotype, and structure; PAs with a high areal weight promoted biofilm formation. Further, we examined the tolerance of matured biofilms on the PAs to various external conditions: (i) storage temperature (−20, 4, 21 °C), environment (aqueous/dry), and time (0–35 days), (ii) pH (2, 4, 6, 7, 8 and 10), and (iii) bacterial contamination by <i>Staphylococcus aureus</i> and <i>Escherichia coli</i>. Generally, PAs increased biofilm resistance, and the areal weight of the PA played a crucial role in it. The PA with the highest areal weight (27 g/m²) provided the highest long-term stability and tolerance of the biofilm and thus was confirmed to be the most suitable tested nanomaterial. The overall results suggest that the presented PAs could be suitable carriers of probiotic biofilm, enabling large-scale production. We also highlight the need for further research on the influence of nanomaterials’ morphology on microbial interactions, possibly enabling target modification for a particular use.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 41","pages":"47867–47878"},"PeriodicalIF":4.3,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.5c01042","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}