ACS Omega最新文献

{"title":"3D Bioprinting in Cancer Modeling and Biomedicine: From Print Categories to Biological Applications","authors":"Jianye Yang,&nbsp;Le Wang,&nbsp;Ruimei Wu,&nbsp;Yanan He,&nbsp;Yu Zhao,&nbsp;Wenchi Wang,&nbsp;Xiaochen Gao,&nbsp;Dan Wang,&nbsp;Lidan Zhao* and Wenfang Li*,&nbsp;","doi":"10.1021/acsomega.4c0605110.1021/acsomega.4c06051","DOIUrl":"https://doi.org/10.1021/acsomega.4c06051https://doi.org/10.1021/acsomega.4c06051","url":null,"abstract":"<p >The continuous interaction between tumor cells and the local microenvironment plays a decisive role in tumor development. Selecting effective models to simulate the tumor microenvironment to study the physiological processes of tumorigenesis and progression is extremely important and challenging. Currently, three-dimensional (3D) bioprinting technology makes it possible to replicate a physiologically relevant tumor microenvironment and induce genomic and proteomic expression to better mimic tumors <i>in vivo</i>. Meanwhile, it plays a crucial role in the prevention and treatment of human diseases, contributing to drug delivery and drug screening, tissue development and regenerative medicine. This paper provides an overview of the categories of 3D bioprinting technology, and the recent advances in the bioinks required for printing. In addition, we summarize the current tumor models based on 3D bioprinting and provide an assessment of possible future biological applications.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c06051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Palladium-Catalyzed Ortho Alkoxylation of Oxazoline Derivatives: An Avenue to Reach Meta-Substituted Electron-Rich Arenes Exploiting Oxazoline as a Removeable Directing Group","authors":"Raheleh Pourkaveh,&nbsp;Dennis Svatunek and Michael Schnürch*,&nbsp;","doi":"10.1021/acsomega.4c0438910.1021/acsomega.4c04389","DOIUrl":"https://doi.org/10.1021/acsomega.4c04389https://doi.org/10.1021/acsomega.4c04389","url":null,"abstract":"<p >An efficient and highly regioselective palladium-catalyzed oxazoline-directed alkoxylation is reported. The reaction proceeds under air and mild temperatures (60 °C). A series of alcohols can be used as alkoxylating agents and concomitantly act as reaction solvents, whereas primary and secondary alcohols are tolerated. Furthermore, fluorinated alcohols can be applied as well, introducing pharmaceutically relevant fluorine-containing groups. 1,3-Dialkoxylated products can be further subjected to hydrolysis transforming the oxazoline-directing group to a carboxylic acid, which can be removed by decarboxylation if desired. This approach demonstrates the capability to reverse the conventional site selectivity of electrophilic aromatic substitution reactions, since it allows the synthesis of arenes with two electron-donating groups in a 1,3-relationship.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c04389","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling miRNA–Gene Regulatory Axes as Promising Biomarkers for Liver Cirrhosis and Hepatocellular Carcinoma","authors":"Varshni Premnath,&nbsp; and ,&nbsp;Shanthi Veerappapillai*,&nbsp;","doi":"10.1021/acsomega.4c0655110.1021/acsomega.4c06551","DOIUrl":"https://doi.org/10.1021/acsomega.4c06551https://doi.org/10.1021/acsomega.4c06551","url":null,"abstract":"<p >Liver cirrhosis, a severe scarring condition of the liver with the potential to progress to hepatocellular carcinoma (HCC), necessitates the development of reliable biomarkers for early detection due to the asymptomatic nature of its early stages. Recent discoveries in microRNAs (miRNAs) hold promise for a noninvasive test, with the potential to significantly improve patient outcomes. Building upon these promising findings, this study investigates gene expression data, identifying distinct sets of DEGs and DEMs using GEO2R. Subsequently, a gene–miRNA network was constructed using Cytoscape to explore potential interactions between DEMs and their target genes (DEGs). Boxplot analysis was carried out to identify and validate differences in gene expression between healthy and diseased tissues. This analysis revealed four significantly differentially expressed genes: CAV1, PEA15, EMP1, and ENAH. Notably, subsequent survival analysis demonstrated that EMP1 and ENAH significantly impact overall patient survival. Intriguingly, the constructed network identified several potential regulatory axes: hsa-miR-191-5p/ENAH, hsa-miR-3158-3p/ENAH, hsa-miR-371a-5p/ENAH, and hsa-miR-6753-5p/EMP1. Crucially, a direct comparison of DEGs and DEMs between liver cirrhosis and HCC pinpointed AGO3, NCOA3, and TNPO1, along with their regulatory elements, as potential key drivers of HCC development in cirrhotic patients, underscoring their importance as targets for early diagnostic and therapeutic strategies. Finally, immunohistochemical (IHC) analysis not only validates our findings but also reiterates the novelty of the identified genes. Overall, elucidating the role of these novel genes and regulatory elements could pave the way for an earlier and more accurate diagnosis of liver diseases.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c06551","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive Review of Plant-Based Cosmetic Oils (Virgin Coconut Oil, Olive Oil, Argan Oil, and Jojoba Oil): Chemical and Biological Properties and Their Cosmeceutical Applications","authors":"Sarah Abdalla,&nbsp;Mohamed Kheireddine Aroua and Lai Ti Gew*,&nbsp;","doi":"10.1021/acsomega.4c0427710.1021/acsomega.4c04277","DOIUrl":"https://doi.org/10.1021/acsomega.4c04277https://doi.org/10.1021/acsomega.4c04277","url":null,"abstract":"<p >Plant-based oils, such as coconut, olive, argan, and jojoba, are abundant in natural emollients and vital fatty acids that hydrate and moisturize the skin. They shield the surface, stop moisture loss, and maintain suppleness of, the skin. They are rich in vitamins, nutrients, and antioxidants that nourish the skin. Virgin coconut oil (VCO) is used as a functional food due to its tremendous health benefits, and olive oil is well-known for its cosmetic and culinary applications. Argan oil contains many antioxidants, vital fatty acids, and vitamin E, while jojoba oil is an excellent moisturizer and conditioner. Plant-based oils can be extracted using various techniques including conventional and chemical extraction methods, and each will affect the yield and quality. Traditional methods like mechanical pressing are less efficient, whereas extraction methods such as pressurized liquid and supercritical fluid extraction may give higher yields and better quality. The chemical composition of olive oil primarily consists of saturated fatty acids (SFAs), polyunsaturated fatty acids (PUFAs), and monounsaturated fatty acids (MUFAs). Argan oil is rich in tocopherols, containing between 60 and 90 mg per 100 g, with only 19 g/100 g of argan oil’s fatty acids saturated. Jojoba oil is liquid wax comprising over 98% triglyceride esters, pure waxes, vitamins, and sterols. This review focuses on the chemical and biological properties, production processes, and applications of natural cosmetic oils (virgin coconut oil, olive oil, argan oil, and jojoba oil), emphasizing their usage in skin care and cosmeceutical products.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c04277","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination and Application of Stress States Based on Finite Element Techniques: A Case Study of the Longmaxi Formation in the Luzhou Block, Sichuan Basin","authors":"Zhaoyi Liu,&nbsp;Hanzhuo Cui,&nbsp;Lingling Han*,&nbsp;Lidong Hou*,&nbsp;Jinsong Bai,&nbsp;Changhao Wang and Hongming Zhan,&nbsp;","doi":"10.1021/acsomega.4c0526010.1021/acsomega.4c05260","DOIUrl":"https://doi.org/10.1021/acsomega.4c05260https://doi.org/10.1021/acsomega.4c05260","url":null,"abstract":"<p >Knowledge of the present-day in situ stress field (PIS) has important theoretical and practical significance for shale gas exploration and development. The Wufeng–Longmaxi Formation in the Luzhou Block serves as the main reservoir of marine shale production in southern China. However, there is no clear understanding of PIS in the Luzhou area, which leads to a series of production problems. To investigate the PIS of deep shale reservoirs in Luzhou, experimental and finite element methods (FEMs) were used. Data obtained from imaging logging data, well deviation data, multipole array acoustic logging (XMAC), and world stress map were used to determine the orientation of the horizontal maximum principal stress (<i>S</i>_H max). Additionally, acoustic emission experiments were employed to determine the magnitude of three principal stresses. Based on FEM, with the stress of a single well as a constraint, a three-dimensional (3D) stress field model was developed. The results show that the orientation of <i>S</i>_H max varies from 90 to 120 °E. Further, there are significant differences in stress regimes across the region, with strike-slip/reverse faulting stress regime (<i>S</i>_H max &gt; <i>S</i>_v ≈ <i>S</i>_h min) in the northern region and strike-slip stress regime in the southern region (<i>S</i>_H max &gt; <i>S</i>_v &gt; <i>S</i>_h min). In addition, geomechanical evaluations of wellbore stability and natural activation of fractures were performed. The Luzhou Block mainly develops two groups of natural fractures (NE–SW trending and NW–SE trending), with NW–SE trending being the dominant fracture development orientation. During the fracturing operation, a pore pressure increment larger than 50 MPa is conducive to maintaining a high opening ratio of the reservoir and improving the gas production efficiency. Horizontal wells drilled in the direction of maximum horizontal principal stress in the Wufeng–Longmaxi Formation reduce the probability of wellbore instability. The research results provide a reference for the effective development of deep shale gas reservoirs in southern Sichuan.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c05260","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blends of Silk Waste Protein and Polysaccharides for Enhanced Wound Healing and Tissue Regeneration: Mechanisms, Applications, and Future Perspectives","authors":"Devipriya Vasudevan,&nbsp; and ,&nbsp;D. Sangeetha*,&nbsp;","doi":"10.1021/acsomega.4c0651810.1021/acsomega.4c06518","DOIUrl":"https://doi.org/10.1021/acsomega.4c06518https://doi.org/10.1021/acsomega.4c06518","url":null,"abstract":"<p >Wound healing is a highly sophisticated process, and therefore, a pioneering approach for designing excellent wound dressings with desirable characteristics vital for maintaining the external wound environment by assessing the inherent conditions of a patient for effective wound healing. Silk fibroin (SF), a versatile biocompatible material, has garnered significant attention for its potential in the field of wound healing and tissue regeneration. When SF is blended with polysaccharides, their synergistic properties can result in a material with enhanced bioactivity and tunable mechanical properties that facilitate the controlled release of therapeutic agents. This review explores how SF interacts with certain polysaccharides such as cellulose, chitosan, alginate, and hyaluronic acid (HA) and also delves into the underlying mechanisms through which these SF-polysaccharide blends induce processes such as cell adhesion, proliferation, and differentiation for enhanced wound healing and tissue regeneration. This review also emphasizes the potential of the aforementioned blends in diverse wound healing applications in conjunction with other treatment approaches, further addressing the current challenges in this domain and future directions for optimizing SF-polysaccharide blends for clinical research.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c06518","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and Synthesis of BODIPY and Its Application in Inhibiting Intestinal Flora","authors":"Jinyao Xu,&nbsp;Hao Huang,&nbsp;Kewei Wang,&nbsp;Jiatao Zhu,&nbsp;Jiale Zhao,&nbsp;Yingshi Zhao,&nbsp;Jiangtao Yue,&nbsp;Cui Ying,&nbsp;Weijing Tao,&nbsp;Qiang Tong*,&nbsp;Li Quan* and Jinbing Xie*,&nbsp;","doi":"10.1021/acsomega.4c0488210.1021/acsomega.4c04882","DOIUrl":"https://doi.org/10.1021/acsomega.4c04882https://doi.org/10.1021/acsomega.4c04882","url":null,"abstract":"<p >BODIPY-based photosensitizers were synthesized and tested for antimicrobial photodynamic therapy, revealing structural modifications enhancing the photodynamic therapy (PDT) effects. This research may lead to new PDT strategies for treating bacterial infections, including those resistant to traditional antibiotics, and offers insights into the prevention and treatment of Alzheimer’s disease through gut microbiota regulation.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c04882","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tailoring Hematite Photoanodes for Improved PEC Performance: The Role of Alcohol Species Revealed by SHAP Analysis","authors":"Takumi Idei,&nbsp;Yuya Nagai,&nbsp;Zhenhua Pan and Kenji Katayama*,&nbsp;","doi":"10.1021/acsomega.4c0863310.1021/acsomega.4c08633","DOIUrl":"https://doi.org/10.1021/acsomega.4c08633https://doi.org/10.1021/acsomega.4c08633","url":null,"abstract":"<p >We explore the synergistic effects of TiO₂ underlayers and varied alcohol species in the precursor solutions on the photoelectrochemical (PEC) performance of hematite photoanodes. Utilizing a robust machine learning (ML) framework combined with comprehensive analytical data sets, we systematically investigate how these modifications influence key physical and chemical properties, directly impacting the efficiency of water splitting processes. Our approach employs an ML model that integrates SHapley Additive exPlanations (SHAP) to quantitatively assess the impact of each dominant descriptor selected in the analytical data on the PEC performance, and they were combined with the SHAP values’ dependence on the experimental operations. Specifically, we focus on the type of alcohol (methanol, ethanol, butanol, and 2-ethyl-1-butanol) used in the precursor solutions as the experimental operation, examining their effects on the dominant descriptors selected in the analytical data. The results from the SHAP analysis reveal that different alcohol species significantly alter the physicochemical properties at the hematite/TiO₂ interface and in bulk hematite. These changes are primarily manifested in the modulation of the density of states and resistance to promote the charge carrier transport. For example, ethanol and butanol were found to enhance the electron density of states at the interface, which correlates with higher photocurrent outputs and improved PEC activity. In contrast, methanol showed a less pronounced effect, suggesting a nuanced interaction between the alcohol molecular structure and hematite surface chemistry. These findings not only underscore the importance of tailored precursor solution chemistry for enhancing PEC performance but also highlight the power of ML tools in uncovering the underlying physical and chemical mechanisms that govern the behavior of complex material systems. This study sets a foundational approach where ML can bridge the gap between empirical observations and theoretical understanding, leading to the rational design of energy materials.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c08633","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simulation Study on Reservoir Stimulation of Multihorizontal Wells for Gas Hydrate Production in Low-Permeability Reservoirs","authors":"Xiaoyang Li*,&nbsp;Shiyu Zhang,&nbsp;Yingli Wang,&nbsp;Qingcheng He,&nbsp;Yule Hu,&nbsp;Fanle Meng,&nbsp;Shanshan Shi and Kuan Li,&nbsp;","doi":"10.1021/acsomega.4c0728010.1021/acsomega.4c07280","DOIUrl":"https://doi.org/10.1021/acsomega.4c07280https://doi.org/10.1021/acsomega.4c07280","url":null,"abstract":"<p >The feasibility of hydrate exploitation technology has been verified by two rounds of trial productions in the South China Sea, but it is also faced with the problem of low gas production efficiency. Therefore, this paper proposed four different hydrate production cases with multihorizontal wells and established simulation models. Then, the influence patterns of reservoir stimulation and offset distances on hydrate dissociation, saturation change, and pressure distribution were studied. To understand hydrate dissociation behaviors and production performances, the coupling effects of multihorizontal wells were discussed. Through simulation, the following conclusions could be drawn: (1) hydrate reservoir stimulation could effectively increase gas production. In these four production models, the cumulative gas production in Case C (multihorizontal wells + reservoir stimulation) was 5.27 times that of Case A (only multihorizontal wells) in 330 days. However, in Case D with screen completions, the gas output was 15.58% less compared with Case C. (2) Different offset distances of horizontal wells had a relatively minor impact on the cumulative gas yield and daily gas capacity. In addition, the variation range of hydrate saturation changed with offset distances of horizontal wells, indicating that hydrate dissociation occurred mainly around horizontal wells and fractures. (3) Considering interwells coupling, the daily gas rate and cumulative gas production of inner wells were higher than outer wells, and the cumulative gas volume increased by 6.4% in 330 days. Temporally and spatially, the hydrate saturation variation between wells was significantly faster than the outward expansion from the horizontal wells. Moreover, nearer to the axis of the horizontal wells, the variation in the hydrate saturation was more pronounced. These results could provide theoretical data to optimize marine hydrate development with multihorizontal wells.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c07280","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and Evaluation of High-Temperature Resistant Polymer Plugging Agent for Water-Based Drilling Fluids","authors":"Jinzhi Zhu,&nbsp;Hongjun Liang,&nbsp;Yilin Liu,&nbsp;Boyang Yu and Chao Ma*,&nbsp;","doi":"10.1021/acsomega.4c0714510.1021/acsomega.4c07145","DOIUrl":"https://doi.org/10.1021/acsomega.4c07145https://doi.org/10.1021/acsomega.4c07145","url":null,"abstract":"<p >As the exploration and development of deep wells have emerged as a key option to extract more oil and gas resources trapped underneath, high-temperature formations impose stringent requirements on the thermal stability of plugging agents used in water-based drilling fluids. In this work, β-cyclodextrin, with its unique conical toroidal rigid stable structure and internal hydrophobic and external hydrophilic special adsorption capacity, was first grafted with maleic anhydride to prepare a silicone polymer and then copolymerized with dimethyldiallylammonium chloride (DMDAAC) in the presence of coupling agent vinyltriethoxysilane (A151) and cross-linking divinylbenzene (DVD) to finally obtain a high-temperature resistant plugging agent (AMMD). Subsequently, the molecular structure was evidenced and the performance of AMMD was examined in the polysulfonate-base fluid via a series of tests including high-temperature high-pressure filtration loss, sand tray plugging, and drilling fluid displacement, and the results were compared with the counterpart Soltex under the same conditions. The optimal synthesis conditions for the plugging agent were found as total monomer concentration of 25%, initiator mass fraction of 1% (based on the mass of monomers), monomer feed ratio of m (DVD):m(A151):m(DMDAAC):m(MD) of 15:3:2:15, pH value of 10, reaction temperature of 75 °C, and reaction time of 4 h. FT-IR spectra indicated that the monomers used to prepare AMMD were successfully involved in the reaction for the design of the plugging agent structure. TGA showed that AMMD has a total weight loss of about 35.98% in the range of 284 to 453 °C. Moreover, the addition of 3%AMMD into the base fluid produced a 4.38-fold and 3.8-fold filtration loss control over 60 min at 200 °C using 400 and 800 mD sand trays, respectively, which were comparatively higher than the commercially available Soltex (ca. 3.72-fold and 3.14-fold, respectively, using 400 and 800 mD). This then contributed to AMMD’s superior plugging performance in drilling fluid based on the drilling fluid displacement experiment, implying that AMMD could find potential use as a plugging agent in polysulfonate drilling fluid under severe geothermal conditions.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c07145","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}