ACS Omega最新文献

{"title":"Dopant-Free Spiro-OMe2 Imidazole-Based Hole-Transporting Material for Stable and Low-Cost Organic–Inorganic Perovskite Solar Cell","authors":"Leila Haji-khan Mirzaei,&nbsp;Hashem Shahroosvand*,&nbsp;Afsaneh Farokhi,&nbsp;Elahe Bayat,&nbsp;Sebastiano Bellani*,&nbsp;Cosimo Anichini,&nbsp;Mohsen Ameri and Francesco Bonaccorso*,&nbsp;","doi":"10.1021/acsomega.4c0544010.1021/acsomega.4c05440","DOIUrl":"https://doi.org/10.1021/acsomega.4c05440https://doi.org/10.1021/acsomega.4c05440","url":null,"abstract":"<p >The engineering of charge transport materials, with electronic characteristics that result in effective charge extraction and transport dynamics, is pivotal for the realization of efficient perovskite solar cells (PSCs). Herein, we elucidate the critical role of terminal substituent methoxy groups (−OCH₃) on the bandgap tuning of the spiro-like hole transport materials (HTMs) to realize performant and cost-effective PSCs. By considering spiro-OMeTAD as the benchmark HTM, we kept the backbone of spiro while replacing diphenylamine with phenanthrenimidazole. This approach significantly decreases the cost of spiro-OMeTAD by reducing the cost of the ancillary group from 0.051 to 0.012 $/g. By increasing the number of methoxy groups on the ancillary ligand from four to eight, the power conversion efficiency (PCE) of the corresponding PSCs containing dopants passed from 17.10% to 18.70%, approaching the value achieved using spiro-OMeTAD containing dopants (PCE = 19.26%). Remarkably, the devices based on dopant-free spiro-OMeTAD have shown a significant loss of PCE, which decreased from 12.9% to 10.1% after 300 h (to 8.2% after 600 h) of light soaking at an open circuit voltage. On the contrary, the cells based on the designed dopant-free HTM demonstrated optimal PCE retention, experiencing a minor drop from 14.4% to 14.1% and 13.2% after 300 and 600 h, respectively, of light soaking at open-circuit voltage.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"9 50","pages":"49132–49142 49132–49142"},"PeriodicalIF":3.7,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c05440","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142842424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonlinear Optical Response of Tetrel-Modified Tetraphenyl-Adamantane Clusters.","authors":"Ferdinand Ziese, Simone Sanna","doi":"10.1021/acsomega.4c08541","DOIUrl":"10.1021/acsomega.4c08541","url":null,"abstract":"<p><p>The second harmonic generation (SHG) properties of adamantane-based tetraphenyl clusters are predicted from first principles and analyzed on the basis of the involved electronic transitions. In particular, the effect of a tetrel substitution in the cluster core on the nonlinear optical response is investigated. Electronic transitions spatially localized at the substituents are found to be responsible for the optical nonlinearities. The intensity of the SHG signal grows with the atomic number of the considered tetrel. As the substitution does not distort the cluster core or substantially alter its symmetry, the enhanced SHG intensity is traced to a higher electron density at the substituents. The latter results in a larger spatial overlap of the states involved in the electronic transitions, which increases their probability. The presented results provide a theoretical foundation for the design of tailored nonlinear optical sources.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"9 50","pages":"49816-49824"},"PeriodicalIF":3.7,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11656209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142875378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of a Simple HPLC/UV Method for Assay and In Vitro Release of Glycosaminoglycan from Pharmaceutical Formulations.","authors":"Gokselin Ozgen, Nahide Zeren Arda Ozturk, Gokce Turan, Merve Turk, Evren Homan Gokce, Ozgen Ozer, Hayriye Icin, Gonul Kayar, Enis Isik, Udaya Kumar Dude, Sakine Tuncay Tanrıverdi","doi":"10.1021/acsomega.4c02161","DOIUrl":"10.1021/acsomega.4c02161","url":null,"abstract":"<p><p>This study encompasses the validation of a simple, rapid, and sensitive HPLC/UV method developed in accordance with the guidelines set by ICH Q2(R2) for obtaining the active pharmaceutical ingredient from the glycosaminoglycan family in topical formulations. Previous methods reported for analyzing glycosaminoglycans in semisolid formulations are relatively complex and time-consuming, involving extraction, purification, and derivatization. This developed analytical method allows for straightforward extraction of the active pharmaceutical ingredient from the matrix, enabling the direct injection of samples. This method was performed and validated for the assay of the pharmaceutical gel and cream formulations to investigate the parameters of linearity (<i>r</i> = 0.9997 for the gel formulation and <i>r</i> = 0.9993 for the cream formulation), precision, accuracy, specificity, and robustness by HPLC/UV. Additionally, this method was used to determine the active ingredient in <i>in vitro</i> release studies. <i>In vitro</i> similarity correlation against commercial products was performed according to the Mann-Whitney <i>U</i> statistical test. The similarity results were 96.5-102.7% for the gel formulation and 98.0-106.0% for the cream formulation, which remained within the limits (75-133.33%) according to USP 1724. This proved that <i>in vitro</i> release profiles for both formulations were like those of the commercial product. In light of the research findings, we believe that the HPLC/UV analysis presented can be further enhanced in the future for determining the levels of active ingredients in various pharmaceutical formulations or for monitoring the levels of glycosaminoglycans in biological matrixes.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"9 50","pages":"49023-49031"},"PeriodicalIF":3.7,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11656206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142875476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soyasaponin Bb/Gelatin-Methacryloyl Hydrogel for Cartilage Inflammation Inhibition","authors":"Yuhan Jiang,&nbsp;Tenghai Li,&nbsp;Bingzhang Liu,&nbsp;Yufeng Tian,&nbsp;Yixin Wang,&nbsp;Tian Li* and Duo Zhang*,&nbsp;","doi":"10.1021/acsomega.4c0748910.1021/acsomega.4c07489","DOIUrl":"https://doi.org/10.1021/acsomega.4c07489https://doi.org/10.1021/acsomega.4c07489","url":null,"abstract":"<p >The main causes of failure for cartilage tissue engineering implants are tissue integration, inflammation, and infection. The development of biomaterials with antiforeign body response (FBR) is of particular importance. Herein, we developed a hydrogel loaded with anti-inflammatory drugs to reduce the inflammatory response that follows implantation. The human chondrocytes were used for in vitro study, and cell-laden hydrogel samples were implanted with the backs of rabbits for in vivo study. Soyasaponin Bb (SsBb) as a traditional Chinese medicine could significantly (<i>P</i> &lt; 0.05) downregulate the expression levels of inflammation-related markers including iNOS, COX-2, and IL-6 in chondrocytes induced by IL-1β through the NF-κB signaling pathway. The in vitro experiments demonstrated that a gelatin-methacryloyl (GelMA) hydrogel loaded with SsBb (SsBb/GelMA) could similarly reduce the gene and protein expression levels of inflammation-related markers (iNOS, COX-2, and IL-6). The in vivo anti-inflammatory effects of the SsBb/GelMA hydrogels were assessed by immunohistochemical staining. The results demonstrated that SsBb/GelMA hydrogels inhibited the inflammatory response and downregulated the expression of the inflammatory cytokine IL-6. Therefore, SsBb/GelMA hydrogels are promising candidates for promoting anti-inflammation and cartilage tissue regeneration of implant surfaces.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"9 50","pages":"49597–49608 49597–49608"},"PeriodicalIF":3.7,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c07489","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142850142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rolling Circle Amplification Integrating with Exonuclease-III-Assisted Color Reaction for Sensitive Telomerase Activity Analysis","authors":"Xiaoya Liu,&nbsp;Xianxian Zhao,&nbsp;Jie Zhang,&nbsp;Yihan Wang and Xiaoping Ye*,&nbsp;","doi":"10.1021/acsomega.4c0383910.1021/acsomega.4c03839","DOIUrl":"https://doi.org/10.1021/acsomega.4c03839https://doi.org/10.1021/acsomega.4c03839","url":null,"abstract":"<p >Telomerase activation can lead to the escape from cell senescence and immortalization, playing a crucial role in the growth and proliferation of cancer cells. Therefore, the detection of telomerase activity is essential for cancer diagnosis and treatment. Herein, we develop a novel ultrasensitive and visually detectable platform. By incorporation of exonuclease-III (Exo-III), this platform achieves dual signal amplification of rolling circle amplification products. Additionally, the colorimetric analysis of 3,3′,5,5′-tetramethylbiphenyl (TMB) chromogenic reaction system provides this approach with unique advantages such as simplicity, speediness, and sensitivity. The detection platform exhibits high sensitivity and specificity in actual sample testing, which aligns closely with results obtained using commercial kits. Moreover, it offers ease-of-use through visual determination by the naked eyes. This finding indicates that our proposed sensing method performs satisfactorily in detecting telomerase in real biological samples. Henceforth, we believe that this sensing platform holds great potential for clinical diagnosis and anticancer drug development.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"9 50","pages":"49081–49087 49081–49087"},"PeriodicalIF":3.7,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c03839","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142850432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tunable Transparent Conductors Based on SnO₂: Theoretical and Experimental Studies of Codoping.","authors":"Wenjing Qian, Xianghui Feng, Yanxue Wang, Ahmet Nazligul, Yiwen Lu, Mingqing Wang, Wei Wu, Kwang Leong Choy","doi":"10.1021/acsomega.4c07860","DOIUrl":"10.1021/acsomega.4c07860","url":null,"abstract":"<p><p>Transparent conducting oxides (TCOs) are widely used in modern electronics because they have both high transmittance and good conductivity, which is beneficial for many applications such as light-emitting diodes. Tailoring electronic states and hence the conductive types by design is important for developing new materials with optimal properties for TCOs. SnO₂, with a wide band gap, low cost, no toxins, and high stability, is a promising host material for TCOs. Here, we performed a set of hybrid-exchange density functional theory calculations on the two-element and three-element codoped SnO₂ by using Sr, Ta, Al, Ga, V, and Nb, which were then validated by the relevant experimental works on SnO₂. As predicted by the first-principles calculations, the controllability of the electronic states to be n- or p-type can be demonstrated experimentally by varying the relative doping concentration between donors (Ta/Nb) and acceptors (Al/Ga). One of the main advantages for these codoping methods is that the charge neutrality problem caused by the dopant can be circumvented. The thin films fabricated showed a low sheet resistance (down to ∼450 Ω<b>/□</b>) and a high optical transparency (above 80%). The combination of our calculations and experimental material fabrication and characterizations has shown a great potential for codoping SnO₂ for (i) the efficient processing of the integrated circuit composed of both p-type and n-type transistors (using the same target precursors during the deposition) and (ii) a good lattice matching for p-n junctions. Most importantly, our calculations, supported by the experimental works, point to a promising route to accelerate the discovery process for the alternative cost-effective and high-performance indium-free TCOs using computational material design.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"9 50","pages":"49674-49682"},"PeriodicalIF":3.7,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11656248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142875474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revealing Local Structure of Angiotensin Receptor-Neprilysin Inhibitor (S086) Drug Cocrystal by Linear and Nonlinear Infrared Spectroscopies.","authors":"Wenjie Xu, Haiyan Xu, Jie Yan, Song Li, Pengyun Yu, Juan Zhao, Fan Yang, Jianping Wang","doi":"10.1021/acsomega.4c07887","DOIUrl":"10.1021/acsomega.4c07887","url":null,"abstract":"<p><p>Structurally knowing the active sites of a drug is important for understanding its therapeutic functions. S086 is a novel angiotensin receptor-neprilysin inhibitor that consists of the molecular moieties of EXP3174 (the active metabolite of the angiotensin receptor blocker losartan) and sacubitril (a neprilysin inhibitor prodrug) in a 1:1 molar ratio. There are two forms of cocrystals of S086, namely, ξ-crystal and α-crystal, which were formed both via intermolecular coordination bonding to calcium ions, with the aid of internal water. The binding state of multiple carboxyl anions (COO^-) to Ca²⁺ of EXP3174 and sacubitril was examined in this study using infrared (IR) absorption spectroscopy, in which the asymmetric stretching (<i>as</i>) and symmetric stretching (<i>ss</i>) modes of the COO^- groups were used as IR probes. Ultrafast two-dimensional (2D) IR spectroscopy was utilized for spectrally assigning the origin of multiple COO^- groups by the presence or absence of interchromophore vibrational coupling. Key structural variation between the two crystal forms was found: in the unit cell of ξ-crystal, the ratio of \"bridging\" and \"bidentate\" types of COO^- binding to Ca²⁺ for four EXP3174 molecules is 2:2, while the ratio is predicted to be 3:1 in the case of α-crystal. However, in both crystals, four sacubitril molecules are believed to similarly form a \"trident\" type of COO^- binding to Ca²⁺. Our study demonstrates that linear and nonlinear IR spectroscopies can be used to characterize local crystal structures of drugs and reveal subtle difference between similar crystal structures.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"9 50","pages":"49683-49691"},"PeriodicalIF":3.7,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11656389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142875439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Aqueous Stability of Anionic Surfactants in High Salinity and Temperature Conditions with SiO2 Nanoparticles","authors":"Mohammed H. Alyousef,&nbsp;Muhammad Shahzad Kamal*,&nbsp;Mobeen Murtaza,&nbsp;Syed Muhammad Shakil Hussain,&nbsp;Arshad Raza,&nbsp;Shirish Patil and Mohamed Mahmoud,&nbsp;","doi":"10.1021/acsomega.4c0848410.1021/acsomega.4c08484","DOIUrl":"https://doi.org/10.1021/acsomega.4c08484https://doi.org/10.1021/acsomega.4c08484","url":null,"abstract":"<p >In chemical-enhanced oil recovery (cEOR), surfactants are widely used but face significant stability challenges in high-salinity brine, where they often degrade or precipitate. Existing methods, such as adding cosurfactants, offer limited compatibility with anionic surfactants and raise economic concerns, creating a need for more robust solutions. This study introduces a novel approach to enhance the stability of anionic surfactants in extreme salinity conditions by incorporating silicon dioxide (SiO₂) nanoparticles (NPs). Our optimized formulation effectively prevents surfactant precipitation and NP aggregation, demonstrating stability in brine with salinity as high as 57,000 ppm and temperatures up to 70 °C, thus addressing the salt tolerance issues seen with conventional anionic surfactants like sodium dodecyl sulfate (SDS). To validate our formulation, we employed multiple experimental techniques, including turbidity, ζ-potential (ZP), and hydrodynamic diameter (HDD) measurements, which confirmed the efficacy of our approach. Results indicated that an optimal SiO₂ NP concentration (0.01 wt %) significantly enhanced SDS stability, with no observed aggregation or precipitation over 7 days. High absolute ZP values (&gt;25 mV), a small HDD (∼37 nm), and a consistent turbidity profile underscored the stability and dispersion of the formulation. This nanoparticle-based method offers a cost-effective and sustainable solution for cEOR, providing enhanced surfactant stability and improved NP dispersibility under high-salinity and high-temperature conditions, representing a valuable advancement in chemical-enhanced oil recovery technology.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"9 50","pages":"49804–49815 49804–49815"},"PeriodicalIF":3.7,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c08484","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142842679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Stachys byzantina</i> K. Koch in the Treatment of Skin Inflammation: A Comprehensive Evaluation of Its Therapeutic Properties.","authors":"José Alisson da Silva Lima, Victor Campana Leite, Jéssica Pereira Silva, Marcelle Andrade Ferrarez, Guilherme Dessupoio Bahia, Luan Vianelo Netto Rezende, Maria Clara Machado Resende Guedes, Gilson Costa Macedo, Natália Prado da Silva, Guilherme Diniz Tavares, Ana Carolina Cruz Reis, Giovanna Oliveira Follis, Vanessa Viana Lempk, Maria Fernanda Fernandes, Elita Scio, Nícolas de Castro Campos Pinto","doi":"10.1021/acsomega.4c08830","DOIUrl":"10.1021/acsomega.4c08830","url":null,"abstract":"<p><p><i>Stachys byzantina</i> is a plant widely cultivated for food and medicinal purposes. <i>Stachys</i> species have been reported as anti-inflammatory, antibacterial, anxiolytic, and antinephritic agents. This study aimed to evaluate the anti-inflammatory potential of the ethanolic extract (EE) from the aerial parts of <i>S. byzantina</i> and its most promising fraction in models of acute and chronic inflammation, including a psoriasis-like mouse model. The EE was fractionated into hexane (HF), dichloromethane (DF), ethyl acetate (AF), and hydroalcoholic (HD) fractions. Screening for anti-inflammatory activity based on nitric oxide inhibition (IC₅₀ μg/mL: HF 24.29 ± 5.87, EE 176.45 ± 18.65), hydroxyl radical scavenging (HF 3.89 ± 0.61, EE 6.38 ± 2.25), β-carotene/linoleic acid assay (HF 10.13 ± 3.81, EE 25.64 ± 2.12), and ORAC identified HF as the most active fraction. Topical application of HF effectively reduced croton oil- and phenol-induced ear edema in mice, with no statistical difference to the reference drugs. A formulation containing HF showed significant activity in the imiquimod-induced psoriasis model, reducing pro-inflammatory cytokines and nitric oxide production in macrophages, with no cytotoxicity to skin cells. Phytochemical analysis of HF revealed the presence of terpenes, steroids (491.68 ± 4.75 mg/g), phenols (34.30 ± 4.96 mg/g), flavonoids (151.77 ± 6.66 mg/g), and α-tocopherol, which was identified and quantified by HPLC-UV analysis (10.56 ± 0.97 mg/g of HF). These findings highlight the therapeutic potential of <i>S. byzantina</i> for skin inflammation, particularly contact dermatitis and psoriasis, encouraging further studies, including in human volunteers.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"9 50","pages":"49899-49912"},"PeriodicalIF":3.7,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11656372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142875333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ionic Dissolution Products of Lithium-, Strontium-, and Boron-Substituted Silicate Glasses Influence the Viability and Proliferation of Adipose Stromal Cells, Fibroblasts, Urothelial and Endothelial Cells.","authors":"Inari Lyyra, Mari Isomäki, Heini Huhtala, Minna Kellomäki, Susanna Miettinen, Jonathan Massera, Reetta Sartoneva","doi":"10.1021/acsomega.4c06587","DOIUrl":"10.1021/acsomega.4c06587","url":null,"abstract":"<p><p>While bioactive glasses (BaGs) have been studied mainly for bone applications, studies have also shown their potential for soft tissue engineering. Incorporating therapeutic ions, such as lithium (Li⁺), strontium (Sr²⁺), and boron (B³⁺) into the BaGs, has been found to promote angiogenesis and wound healing. However, a systematic study on the impact of Li⁺, Sr²⁺, B³⁺, and the other ions in the BaGs, has not been conducted on a wide range of cells. Although the interactions between the BaGs and cells have been studied, it is difficult to compare the results between studies and conclude the impact of BaGs between cell types due to the variability of culture conditions, cells, and materials. We aim to evaluate the dissolution behavior of Li-, Sr-, and B-substituted BaGs and the effects of their ionic dissolution products on the viability, proliferation, and morphology of multiple cell types: human adipose stromal cells (hASCs), human lung fibroblasts (cell line WI-38), human urothelial cells (hUCs), and human umbilical vein endothelial cells (HUVECs). In the dissolution study, the B-substituted glasses induced a higher increase in pH and released more ions than the silicate glasses. The undiluted BaG extracts supported the viability and proliferation of all the other cell types except the hUCs. Diluting the BaG extracts to 1:10 restored the viability of hUCs but induced distinctive morphological changes. Diluting the extracts more (1:100) almost fully restored the hUC morphology. To conclude, the ionic dissolution products of Li-, Sr-, and B-substituted BaGs seem beneficial for hASCs, WI-38, hUCs, and HUVECs, but attention must be paid to the ion concentrations.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"9 50","pages":"49348-49367"},"PeriodicalIF":3.7,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11656255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142875412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}