ACS Omega最新文献

{"title":"Tuning Printability and Adhesion of a Silver-Based Ink for High-Performance Strain Gauges Manufactured via Direct Ink Writing.","authors":"Md Alamgir Hossain, Gabriela Plautz-Ratkovski, Joshua DeGraff, Tarik J Dickens, Zhiyong Liang, Curtis Hill, Jennifer Jones, Subramanian Ramakrishnan","doi":"10.1021/acsomega.4c09042","DOIUrl":"10.1021/acsomega.4c09042","url":null,"abstract":"<p><p>Structural health monitoring (SHM) systems are critical in ensuring the safety of space exploration, as spacecraft and structures can experience detrimental stresses and strains. By deploying conventional strain gauges, SHM systems can promptly detect and assess localized strain behaviors in structures; however, these strain gauges are limited by low sensitivity (gauge factor, GF ∼ 2). This study introduces an approach to printing strain gauges with high sensitivity, while also considering stretchability and long-term durability. Through direct ink writing (DIW), these devices can be produced by the extrusion of a wide range of viscoelastic inks. The viscoelastic properties of the ink can be tuned with the help of additives to aid in the processing for a desired application. In this work, a series of inks were prepared from commercially available CB028 (silver ink used in screen printing) by adding a combination of ethyl cellulose (EC) and polyolefin (PO) (additives). With the goal of optimizing the long-term sensing response of the printed strain gauges, a systematic study of the rheological properties (frequency sweep analyses, yield stress, viscoelastic recovery, viscosity measurements, and tack tests) was conducted. A viscoelastic window approach was used to predict the optimal properties of the formulated inks. Using this approach, it was determined that 90% CB028, 5% EC, and 5% PO provided enhanced elastic properties, adhesion, and peel strength compared to commercial CB028. The formulated ink has enhanced tack (129 mN/mm²) and peel strength (23.3 kJ/mm²), which led to a viscoelastic window ideal for direct ink writing of the strain gauges. Printed structures were tested in a three-point bending configuration to record the piezoresistive responses that were correlated to the formulated rheological properties and underlying microstructure. The results revealed gauge factors as high as 106 with stable sensing responses for more than 300 cycles of strain. Scanning electron microscopy analysis also revealed minimal crack formation, which resulted in a stable response. The research demonstrated the feasibility of developing high-performance inks for potential printed strain gauge applications.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 1","pages":"1429-1439"},"PeriodicalIF":3.7,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11739956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142996148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the Mechanism of Gas Diffusion in Coal Particles under the Coupled Effects of Gas Pressure and Temperature.","authors":"Meihua Huang, Dong Han, Yifan Wu, Gelan Zhao","doi":"10.1021/acsomega.4c09979","DOIUrl":"https://doi.org/10.1021/acsomega.4c09979","url":null,"abstract":"<p><p>To investigate the gas diffusion mechanism in coal particles under the coupled effects of gas pressure and temperature, a low-temperature liquid nitrogen adsorption experiment was first conducted to obtain the pore structure characteristics and pore size distribution patterns of the coal samples. Subsequently, a methane diffusion experiment was performed on coal particles with simultaneous increases in gas pressure and temperature using a unipore model to solve the diffusion coefficient. Finally, models for the diffusion coefficient of free-state methane and adsorbed-state methane were established, with their applicability discussed. The results indicate that the pore structure of the coal samples exhibits an approximately unimodal distribution, predominantly consisting of mesopores. As the gas pressure and temperature increase, the tortuosity of the coal sample pores also increases. Both the desorption volume and desorption rate of gas rise with the simultaneous increase in gas pressure and temperature, and overall, the diffusion coefficient of coal particles tends to increase under these conditions. Methane diffusion in coal particles is primarily governed by the surface diffusion of adsorbed methane, with gas pressure exerting a greater influence on surface diffusion than temperature. The findings of this study contribute to the understanding of the gas diffusion mechanism in coal and are of significant importance for improving gas extraction rates and preventing gas-related disasters.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 1","pages":"1780-1788"},"PeriodicalIF":3.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11740106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142996074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery of PRMT5 N-Terminal TIM Barrel Ligands from Machine-Learning-Based Virtual Screening.","authors":"Zhihang Shen, Gustavo Seabra, Jason Brant, Kalyanee Shirlekar, Loic Deleyrolle, Benjamin Lewis, Chenglong Li","doi":"10.1021/acsomega.4c08661","DOIUrl":"10.1021/acsomega.4c08661","url":null,"abstract":"<p><p>Protein arginine methyltransferase 5 (PRMT5), which symmetrically dimethylates cytosolic and nuclear proteins, has been demonstrated as an important cancer therapeutic target. In recent years, many advanced achievements in PRMT5 inhibitor development have been made. Most PRMT5 inhibitors in the clinical trial focus on targeting the C-terminal catalytic domain, whereas developing small molecules to interrupt the PRMT5/pICLn (methylosome subunit) protein-protein interface is also of great importance for inhibiting PRMT5. Here, we describe a machine-learning-based virtual screening method and use this novel pipeline to screen small-molecule inhibitors of the PRMT5/pICLn interaction. 18 compounds were manually selected for experimental testing. One compound, Z319334062, showed surface plasmon resonance-binding affinity to the target (<i>K</i> _D = 21.5 μM) and dose-dependently inhibited symmetric dimethylation levels in patient-derived glioblastoma cell lines.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 1","pages":"1156-1163"},"PeriodicalIF":3.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11740121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142996085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid Increase in Soil Respiration and Reduction in Soil Nitrate Availability Following CO₂ Enrichment in a Mature Oak Forest.","authors":"Angeliki Kourmouli, R Liz Hamilton, Johanna Pihlblad, Rebecca Bartlett, Angus Robert MacKenzie, Iain P Hartley, Sami Ullah, Zongbo Shi","doi":"10.1021/acsomega.4c09495","DOIUrl":"https://doi.org/10.1021/acsomega.4c09495","url":null,"abstract":"<p><p>In the future, with elevated atmospheric CO₂ (eCO₂), forests are expected to increase woody biomass to capture more carbon (C), though this is dependent on soil nutrient availability. While young forests may access unused nutrients by growing into an unexplored soil environment, it is unclear how or if mature forests can adapt belowground under eCO₂. Soil respiration (<i>R</i> _s) and nutrient bioavailability are integrative ecosystem measures of below-ground dynamics. At Birmingham's Institute of Forest Research Free Air CO₂ Enrichment (BIFoR FACE) facility, we investigated the effects of eCO₂ (+150 ppm above ambient) on a mature oak forest during the first year of exposure. We observed an annual R_s increase of ∼21.5%; 996 ± 398 g C m^-2 year^-1 (ambient) to 1210 ± 483 g C m^-2 year^-1 (eCO₂). The eCO₂ impact was greater on belowground nutrient cycling, with monthly nitrate availability decreasing by up to 36%. These results show that high C uptake resulted in higher soil respiration with a concomitant decrease in the level of soil nitrate during the first year. These belowground responses and their long-term dynamics will have implications for the carbon budget of mature forest ecosystems in changing climate.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 1","pages":"1624-1634"},"PeriodicalIF":3.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11739980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142996225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silica Nanoparticles Modified by Biphenyl Groups for Crack-Free Coating on Synthetic Paper.","authors":"Yuanqing Fan, Haifeng Lin, Libin Kang, Shunai Che","doi":"10.1021/acsomega.4c08360","DOIUrl":"https://doi.org/10.1021/acsomega.4c08360","url":null,"abstract":"<p><p>Water-based acrylic emulsions are a crucial component of water-based ink. Preventing visible cracks in emulsion coating during drying is a great challenge due to the high polarity and high surface tension of water. Herein, we propose that the cracking resistance of the coating can be enhanced through the incorporation of hydrophobic silica nanoparticles. The hydrophobic silica nanoparticles were fabricated by the modification of biphenyl groups to the surface of silica nanoparticles through postcoating using dimethoxydiphenylsilane. The presence of phenyl groups on the surface of biphenyl-modified silica nanoparticles (BPSNs) was confirmed by the Raman spectrum, Sears number, and zeta potential measurements. The formation of large cracks was significantly reduced by the incorporation of BPSN into water-based acrylic emulsion coatings. BPSN strengthens the forces of attraction between the resin particles in coatings, enabling the coating to resist the stresses caused by drying. This work provides a simple method to obtain crack-free coatings of water-based acrylic emulsion on a nonabsorbent substrate, offering a promising strategy for the printing industry to broaden the application of water-based ink.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 1","pages":"1061-1066"},"PeriodicalIF":3.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11739971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142996272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selected Ion Extraction of Peptides with Heavy Isotopes and Hydrogen Loss Reduces the Type II Error in Plasma Proteomics.","authors":"Jaimie Dufresne, Zhuo Zhen Chen, Pallvi Sehajpal, Peter Bowden, Ja-An Ho, Cheng-Chih Richard Hsu, John G Marshall","doi":"10.1021/acsomega.4c05624","DOIUrl":"10.1021/acsomega.4c05624","url":null,"abstract":"<p><p>Naturally occurring peptides display a wide mass distribution after ionization due to the presence of heavy isotopes of C, H, N, O, and S and hydrogen loss. There is a crucial need for sensitive methods that collect as much information as possible about all plasma peptide forms. Statistical analysis of the delta mass distribution of peptide precursors from MS/MS spectra that were matched to 63,077 peptide sequences by X!TANDEM revealed Gaussian peaks representing heavy isotopes and hydrogen loss at integer delta mass values of -3, -2, -1, 0, +1, +2, +3, +4, and +5 Da. Human plasma samples were precipitated in acetonitrile, and the resulting proteins were collected over a quaternary amine resin, eluted with NaCl, digested with trypsin, and analyzed by nano liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) with an orbital ion trap (OIT). Fragment spectra (MS/MS) generated from the OIT data were fit to human fully tryptic peptides by X!TANDEM, which led to the identification of 3,888 protein gene symbols represented by three or more peptides (<i>n</i> ≥ 3). The peptide counts to plasma proteins from experimental MS/MS spectra were corrected against 29 blank LC-ESI-MS/MS spectra and 30 million random MS/MS control spectra to yield 2,784 true positive proteins (<i>n</i> ≥ 3; <i>q</i> ≤ 0.01). Peptides identified by fragmenting ions with Gaussian heavy isotopes and hydrogen loss that were matched to known plasma proteins, such as albumin (ALB), were shown to be true positives and agreed with the peptide sequences identified in the monoisotopic peak. Accepting the ions from the monoisotopic peak alone (±0.1 Da) yielded only 382 plasma proteins (<i>n</i> ≥ 3; type I error <i>q</i> ≤ 0.01; type II error ∼86%). In contrast, accepting all ions within ±0.1 Da around the hydrogen loss, monoisotopic, and heavy isotopic peaks led to the identification of 963 proteins (<i>n</i> ≥ 3; <i>q</i> ≤ 0.01; type II error ∼60%). Using the power of the OIT to resolve the Gaussian peaks from heavy isotopes and hydrogen loss resulted in the identification of three times more proteins with high confidence and a much lower type II error than analyzing peptides from the monoisotopic peak alone. The resolving power of the OIT may be exploited to increase observation frequencies and provide greater proteomic coverage and statistical power in comparative proteomics studies.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 1","pages":"281-293"},"PeriodicalIF":3.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11739973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142996261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Numerical Investigation of Proton Exchange Membrane Fuel Cells with Symmetrical Serpentine Channels Equipped with Baffles.","authors":"Yanqiang Wei, Yifan Feng, Jiaping Zhao, Jiawen Li, Hongtai Li, Jinzhu Tan","doi":"10.1021/acsomega.4c09174","DOIUrl":"https://doi.org/10.1021/acsomega.4c09174","url":null,"abstract":"<p><p>The design of the flow field structure for bipolar plates significantly influences the output performance of proton exchange membrane fuel cells (PEMFCs). Adding baffles in the flow channels can enhance the transportation of reactants and electrochemical performance of the PEMFCs. In this study, three types of baffles with different shapes and sizes were designed. Computational fluid dynamics (CFD) models for the PEMFCs with a symmetrical serpentine flow field (SSFF), both without baffles and with baffles, were established using the CFD method. Numerical simulations for the PEMFCs, both without baffles and with baffles, were performed by FLUENT software. The simulation results show that the PEMFCs with baffles demonstrated improved oxygen transport and increased reaction gas concentrations in the flow channels compared to the PEMFCs without baffles. The velocity magnitude exhibited abrupt changes as the fluid passed through the baffles due to their disturbance effect. Specially, the PEMFCs without baffles had a maximum power density of 0.601 W/cm², while the PEMFCs with rectangular baffles reached a maximum power density of 0.755 W/cm², which was enhanced by 25.6% due to the arrangement of baffles in the symmetrical serpentine flow channels.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 1","pages":"1510-1518"},"PeriodicalIF":3.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11739975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142996265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and Adsorption Performance of Walnut Waste-Based Magnetic Activated Carbon with High Specific Surface Area.","authors":"Resalat Yimin, Reyangul Abla, Gulbagar Dawut, Abdukader Abdukayum, Bin Xiong","doi":"10.1021/acsomega.4c05032","DOIUrl":"10.1021/acsomega.4c05032","url":null,"abstract":"<p><p>Magnetic activated carbon (MAC) derived from agricultural waste shows significant potential for the removal of norfloxacin (NOR) from wastewater. However, understanding the removal mechanisms, efficiency, and recyclability of MAC produced from walnut green husk and ferrocene for NOR remains a challenge. In this study, walnut green husk-based MAC (HQP-MC) was synthesized, and changes in surface functionality, mechanisms for NOR removal, and major influencing factors were investigated. The results indicated that HQP-MC predominantly features a mesoporous structure with a diverse array of surface functional groups, including -OH, NH₂, C=O, and C-O. Additionally, HQP-MC demonstrates a remarkable adsorption capacity for NOR, achieving 226.8 mg·g^-1 at 298 K and pH 7.0 under various substrates and experimental conditions. This high capacity can be attributed to a significantly enhanced specific surface area and pore volume, which increased by factors of 2.40 and 2.46, respectively, compared with pristine activated carbon. Moreover, HQP-MC exhibited an exceptional saturation magnetic strength of 11.5 emu·g^-1, along with a reusability rate of 80.5% after ten cycles. The adsorption kinetics were effectively described by the pseudo-second-order model and the Langmuir isotherm model. This study provides valuable insights into the sustainable development of magnetic adsorbent materials derived from agricultural waste and their applications in wastewater decontamination.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 1","pages":"498-508"},"PeriodicalIF":3.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11740147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142996163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supramolecular Ni(II)-Selective Gel Assembly toward Construction of a Schottky Barrier Diode.","authors":"Vaishali Singh, Deepak Kumar Chauhan, Rampal Pandey","doi":"10.1021/acsomega.4c06387","DOIUrl":"10.1021/acsomega.4c06387","url":null,"abstract":"<p><p>A mechanically stable and thermo-irreversible supramolecular Ni(II)-selective gel (<b>MG</b>) has been developed by utilizing the N,O-donor Schiff base (E)-1-((4-(diethylamino)phenylimino)-methyl)naphthalen-2-ol (<b>HL</b>) gelator and Et₃N in binary THF:CH₃OH (1:1) solutions at room temperature (rt). Metallogel <b>MG</b> has been characterized by spectral and analytical techniques, i.e., ESI-MS, FT-IR, NMR (¹H & ¹³C), powder-XRD, FE-SEM, and rheological analysis. Further, noncovalent interactions responsible for the gelation mechanism have been illustrated with the aid of powder-XRD and FE-SEM analysis. The toughness, viscoelasticity, and flow behavior of <b>MG</b> were explored through rheological studies. Rheological and compressive measurements showed higher values of storage modulus and rigidity of <b>MG</b>; however, the flow property along with enrichment of toughness in <b>MG</b> can be an analytical metric for various engineering and industrial applications. Eventually, a Schottky barrier diode (SBD) was successfully constructed to mimic the functionality of <b>MG</b>-based metal-semiconductor (MS) junction devices for possible application in electrical engineering.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 1","pages":"378-389"},"PeriodicalIF":3.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11740625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142996079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery of 2-Pyrazolines That Inhibit the Phosphorylation of STAT3 as Nanomolar Cytotoxic Agents.","authors":"Tejaswini P Siddappa, Akshay Ravish, Zhang Xi, Arunkumar Mohan, Swamy S Girimanchanaika, Niranjan Pattehali Krishnamurthy, Shreeja Basappa, Santosh L Gaonkar, Peter E Lobie, Vijay Pandey, Basappa Basappa","doi":"10.1021/acsomega.3c10504","DOIUrl":"10.1021/acsomega.3c10504","url":null,"abstract":"<p><p>STAT3 has emerged as a validated target in cancer, being functionally associated with breast cancer (BC) development, growth, resistance to chemotherapy, metastasis, and evasion of immune surveillance. Previously, a series of compounds consisting of imidazo[1,2-<i>a</i>]pyridine tethered 2-pyrazolines (referred to as ITPs) were developed that inhibit STAT3 phosphorylation in estrogen receptor-positive (ER+) BC cells. Herein, a new library of derivatives consisting of imidazo[1,2-<i>a</i>]pyridine clubbed 2-pyrazolines <b>2</b>(<b>a</b>-<b>o</b>) and its amide derivatives <b>3</b>(<b>a</b>-<b>af</b>) have been synthesized. Among these derivatives, <b>3n</b> and <b>3p</b> displayed efficacy to reduce ER+ BC cell viability, with IC₅₀ values of 55 and 15 nM, respectively. Molecular docking simulations predicted that compound <b>3p</b> bound to STAT3 protein, with a binding energy of -9.56 kcal/mol. Using Western blot analysis, it was demonstrated that treatment of ER+ BC cells with compound <b>3p</b> decreased the levels of phosphorylated STAT3 at the Tyr705 residue. In conclusion, this investigation presents the synthesis of imidazopyridine clubbed 2-pyrazolines that exhibit significant efficacy in reducing viability of ER+ BC cells. In silico docking and Western blot analyses together support compound <b>3p</b> as a promising novel inhibitor of STAT3 phosphorylation, suggesting its potential as a valuable candidate for further therapeutic development.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 1","pages":"114-126"},"PeriodicalIF":3.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11740381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142996071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}