ACS Omega最新文献_第2页

Tracking Perfluorooctanoic Acid in Tap and River Water Employing Screen-Printed Electrodes Modified with Molecularly Imprinted Polymers 用分子印迹聚合物修饰的丝网印刷电极跟踪自来水和河水中的全氟辛酸

IF 3.7 3区化学

ACS Omega Pub Date : 2025-04-12 DOI: 10.1021/acsomega.4c1047310.1021/acsomega.4c10473

Fatemeh Ahmadi Tabar*, Joseph W. Lowdon, Margaux Frigoli, Robert D. Crapnell, Thomas J. Cleij, Hanne Diliën, Craig E. Banks, Kasper Eersels, Bart van Grinsven and Patrick Wagner*,

{"title":"Tracking Perfluorooctanoic Acid in Tap and River Water Employing Screen-Printed Electrodes Modified with Molecularly Imprinted Polymers","authors":"Fatemeh Ahmadi Tabar*, Joseph W. Lowdon, Margaux Frigoli, Robert D. Crapnell, Thomas J. Cleij, Hanne Diliën, Craig E. Banks, Kasper Eersels, Bart van Grinsven and Patrick Wagner*, ","doi":"10.1021/acsomega.4c1047310.1021/acsomega.4c10473","DOIUrl":"https://doi.org/10.1021/acsomega.4c10473https://doi.org/10.1021/acsomega.4c10473","url":null,"abstract":"While existing polyfluoroalkyl substances (PFAS) detection techniques are highly sensitive, their broader implementation is limited by the need for expensive equipment, lengthy analysis times, and specialized personnel. This underscores the need for fast, reliable, cost-effective, and accessible PFAS detection methods to avoid exposure to these pollutants and expedite the remediation of contaminated environments. Currently, portable electrochemical sensors for in situ contaminant detection are gaining significant attention. This study focuses on developing an electrochemical sensor for on-site perfluorooctanoic acid (PFOA) detection utilizing screen-printed electrodes (SPEs) modified with molecularly imprinted polymers (MIPs). The sensor’s performance is evaluated using electrochemical impedance spectroscopy (EIS), with the electrochemical signals for PFOA detection arising from the specific interactions between MIPs and PFOA. The sensor exhibits a linear response to PFOA in phosphate-buffered saline within a concentration range of 0.1 nM to 10 μM, a detection limit of 19 ± 1 pM, and a quantification limit of 42 ± 3 nM. The selectivity of the sensor is assessed by measuring its response to four different PFAS compounds. Additionally, its real-world applicability is tested by analyzing the EIS response in tap and river water samples. The developed sensor, which combines an easy-to-use dipstick format with readily prepared SPEs, has the potential for large-scale production for in situ PFOA detection.","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 15","pages":"15018–15028 15018–15028"},"PeriodicalIF":3.7,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c10473","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metal-Oxide-Decorated Mesoporous Silica Chemiresistors for Exhaled Biomarker Detection 用于呼出生物标志物检测的金属氧化物修饰介孔二氧化硅化学电阻器

IF 3.7 3区化学

ACS Omega Pub Date : 2025-04-11 DOI: 10.1021/acsomega.5c0091210.1021/acsomega.5c00912

Minchul Sung, Min Jun Oh, Tiancheng Wang, Jaeyong Ahn, Joon Hak Oh, Kathleen J. Stebe, Daeyeon Lee*, Geelsu Hwang* and Jin Woong Kim*,

{"title":"Metal-Oxide-Decorated Mesoporous Silica Chemiresistors for Exhaled Biomarker Detection","authors":"Minchul Sung, Min Jun Oh, Tiancheng Wang, Jaeyong Ahn, Joon Hak Oh, Kathleen J. Stebe, Daeyeon Lee*, Geelsu Hwang* and Jin Woong Kim*, ","doi":"10.1021/acsomega.5c0091210.1021/acsomega.5c00912","DOIUrl":"https://doi.org/10.1021/acsomega.5c00912https://doi.org/10.1021/acsomega.5c00912","url":null,"abstract":"A metal-oxide-decorated mesoporous silica (MOMS) chemiresistor platform enables the selective detection of disease-specific volatile organic compounds (VOCs) in exhaled breath. Functionalization of these mesoporous structures with metals and metal oxides facilitates the detection of a wide range of VOCs. To create a sensing architecture with a bicontinuous morphology that optimizes molecular diffusion and electron transport pathways, we employ physically confined polymerization-induced phase separation (PC-PIPS) to fabricate template-directed mesoporous structures with controlled film thicknesses ranging from 1 to 5 μm. Incorporation of metal oxides (SnO2, ZnO) and noble metals (Pt, Au) forms p–n heterojunctions, enhancing sensitivity and selectivity through modulation of electron depletion layers. The MOMS chemiresistors demonstrate distinct response patterns toward key biomarkers, including hydrogen sulfide (periodontal disease), toluene (gingivitis), formaldehyde (oral carcinoma), and acetone (diabetes mellitus). Response magnitudes range from 1.75–5.66 at 10 ppm to 5.56–12.13 at 100 ppm of H2S, with unique electronic signatures, enabling identification of complex gas mixtures. This scalable and versatile fabrication approach establishes MOMS chemiresistors as a promising platform for noninvasive, early-stage disease detection via breath analysis.","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 15","pages":"15629–15636 15629–15636"},"PeriodicalIF":3.7,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.5c00912","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting Iron–Sulfur Cluster Redox Potentials: A Simple Model Derived from Protein Structures 预测铁硫簇氧化还原电位：从蛋白质结构推导的简单模型

IF 3.7 3区化学

ACS Omega Pub Date : 2025-04-11 DOI: 10.1021/acsomega.5c0197610.1021/acsomega.5c01976

Jiyeon Min, Fidaa Ali, Bernard R. Brooks, Barry D. Bruce and Muhamed Amin*,

{"title":"Predicting Iron–Sulfur Cluster Redox Potentials: A Simple Model Derived from Protein Structures","authors":"Jiyeon Min, Fidaa Ali, Bernard R. Brooks, Barry D. Bruce and Muhamed Amin*, ","doi":"10.1021/acsomega.5c0197610.1021/acsomega.5c01976","DOIUrl":"https://doi.org/10.1021/acsomega.5c01976https://doi.org/10.1021/acsomega.5c01976","url":null,"abstract":"Iron–sulfur (Fe–S) clusters are critical cofactors in metalloproteins, essential for cellular processes such as energy production, DNA repair, enzymatic catalysis, and metabolic regulation. While Fe–S cluster functions are intimately linked to their redox properties, their precise roles in many proteins remain unclear. In this study, we present a regression model based on experimental redox potential (Em) data, utilizing only two features: the Fe–S cluster’s total charge and the Fe atoms’ average valence. This model achieves a high correlation with experimental data (R2 = 0.82) and an average prediction error of 0.12 V. Applying this model across the Protein Data Bank, we predict Em values for all cataloged Fe–S clusters, uncovering redox potential trends across diverse cluster classes. The computed redox potentials showed strong agreement with experimental values, achieving an overall accuracy of 88%. This streamlined, computationally accessible approach enhances the annotation and mechanistic understanding of Fe–S proteins, offering new insights into the redox variability of electron transport proteins. Our model holds promise for advancing studies of metalloprotein function and facilitating the design of bioinspired redox systems.","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 15","pages":"15790–15798 15790–15798"},"PeriodicalIF":3.7,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.5c01976","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Data-Driven Diagnosis of Model–Plant Mismatch in MIMO Closed-Loop Control System MIMO闭环控制系统模型-对象不匹配的数据驱动诊断

IF 3.7 3区化学

ACS Omega Pub Date : 2025-04-11 DOI: 10.1021/acsomega.4c1079810.1021/acsomega.4c10798

Dan Ling, Tengfei Jiang, Junwei Sun and Yan Wang*,

{"title":"Data-Driven Diagnosis of Model–Plant Mismatch in MIMO Closed-Loop Control System","authors":"Dan Ling, Tengfei Jiang, Junwei Sun and Yan Wang*, ","doi":"10.1021/acsomega.4c1079810.1021/acsomega.4c10798","DOIUrl":"https://doi.org/10.1021/acsomega.4c10798https://doi.org/10.1021/acsomega.4c10798","url":null,"abstract":"Control performance of a multivariable closed-loop control system greatly depends on the quality of the process model used in the controller design. Thus, it is highly desirable that the discrepancy between the process model and the plant can be measured. In this study, a novel methodology is proposed for model–plant mismatch diagnosis based on an internal model control framework. The outputs are first whitened, and the external disturbance model is identified. A process model residual measuring the process model–plant discrepancy is put forward based on the identified disturbance model and the control model. Three model quality indices are defined to monitor the model qualities for the overall process, individual outputs, and specific input–output channels. This presented methodology can identify the mismatched subchannels and isolate the model–plant mismatch from the changes in controller parameters. The capability of the presented methodology is demonstrated using a simulated column process and a Tennessee Eastman benchmark problem.","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 15","pages":"15148–15159 15148–15159"},"PeriodicalIF":3.7,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c10798","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrophilic Susceptibility of Graphene Quantum Dots: Hypochlorous versus Hypobromous Acids─Experimental and Theoretical Study 石墨烯量子点的亲电敏感性：次氯酸与次溴酸─实验与理论研究

IF 3.7 3区化学

ACS Omega Pub Date : 2025-04-11 DOI: 10.1021/acsomega.5c0150010.1021/acsomega.5c01500

Guilherme Justiniano Mizumoto, Nelson Henrique Morgon, Aguinaldo Robinson de Souza and Valdecir Farias Ximenes*,

{"title":"Electrophilic Susceptibility of Graphene Quantum Dots: Hypochlorous versus Hypobromous Acids─Experimental and Theoretical Study","authors":"Guilherme Justiniano Mizumoto, Nelson Henrique Morgon, Aguinaldo Robinson de Souza and Valdecir Farias Ximenes*, ","doi":"10.1021/acsomega.5c0150010.1021/acsomega.5c01500","DOIUrl":"https://doi.org/10.1021/acsomega.5c01500https://doi.org/10.1021/acsomega.5c01500","url":null,"abstract":"Graphene quantum dots (GQDs) are water-soluble, are biocompatible, and exhibit low toxicity. These properties, along with their adjustable and efficient fluorescent emission, make GQDs valuable for biological applications, particularly as spectroscopic nanosensors. In this context, GQDs have been utilized to detect hypochlorous acid (HOCl). While HOCl is a well-known synthetic disinfectant, it is also naturally produced by the enzyme myeloperoxidase (MPO) in mammals. This heme-peroxidase also catalyzes the production of hypobromous acid (HOBr), a more potent halogenating agent. In our study, we compared the reactivity of HOCl and HOBr with GQDs. By monitoring the fluorescence bleaching of the GQDs, we demonstrated that HOBr is more reactive than HOCl. The increased reactivity was attributed to HOBr’s higher electrophilicity. The electrophilic nature of the reaction was further confirmed by introducing nicotine as a chlorination catalyst. Anisole did not inhibit the electrophilic attack, confirming the high reactivity of GODs with HOBr. The enzyme MPO was used to generate HOBr through oxidation of Br– by H2O2. Thus, the enzymatic activity of MPO could be monitored by GQDs’ fluorescence bleaching, and the efficiency of MPO inhibitors could be evaluated. We applied differential function theory (DFT) methodologies to support our experimental findings, proposing a transition state for the electrophilic attack. Consistent with our experimental results, the energetic barrier for the reaction with HOBr was lower than that for HOCl. Overall, our results indicate the susceptibility of GQDs to electrophilic attacks by hypohalous acids and highlight new opportunities for biological applications.","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 15","pages":"15753–15761 15753–15761"},"PeriodicalIF":3.7,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.5c01500","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential of Compost and Spent Coffee Grounds as Sources of Humic-Like Substances: Extraction Modeling and Optimization by Fractional Factorial Design 堆肥和废咖啡渣作为腐植酸样物质来源的潜力：提取模型和分数析因设计优化

IF 3.7 3区化学

ACS Omega Pub Date : 2025-04-11 DOI: 10.1021/acsomega.5c0176610.1021/acsomega.5c01766

Dominik Nieweś*, and , Kinga Marecka,

{"title":"Potential of Compost and Spent Coffee Grounds as Sources of Humic-Like Substances: Extraction Modeling and Optimization by Fractional Factorial Design","authors":"Dominik Nieweś*,  and , Kinga Marecka, ","doi":"10.1021/acsomega.5c0176610.1021/acsomega.5c01766","DOIUrl":"https://doi.org/10.1021/acsomega.5c01766https://doi.org/10.1021/acsomega.5c01766","url":null,"abstract":"Humic substances (HSs) play a crucial role in soil health and have potential applications beyond agriculture. This study evaluates the renewable raw materials such as compost from urban green waste (GWC) and spent coffee grounds (SCG) as sources of humic-like substances (HLSs), which may be an alternative to traditional resources such as peat, lignite, and leonardite. The quantitative analysis focused on modeling and optimizing the efficiency of ultrasound-assisted extraction of humic-like acids (HLAs) as a function of time, ultrasound intensity, extractant concentration (NaOH), and temperature. Experimental points were determined based on the experimental matrix according to fractional factorial design (FFD), and the obtained polynomial models were evaluated using the Fisher test, lack of fit assessment, and determination coefficients. Experimental verification with optimal values of the evaluated parameters demonstrated the possibility of extracting HLAs from GWC and SCG at levels of 27.08 and 19.11%, respectively. The qualitative analysis included humic-like and fulvic-like acids and their comparison with reference samples. Spectroscopic methods (UV–vis, ATR-FTIR, CP/MAS, and 13C NMR) as well as elemental analysis (CHNSO) were used in this part of the study. The results obtained showed the presence of functional groups characteristic of humic substances (polysaccharides, phenols, alcohols, and amides) in the molecular structure of the products. Additionally, they exhibited a higher content of nitrogen and sulfur compared to commercial samples, as well as lower hydrophobicity, which may indicate their biological activity.","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 15","pages":"15762–15774 15762–15774"},"PeriodicalIF":3.7,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.5c01766","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vacuum-Assisted Synthesis of Solid-State Fluorescent Carbon Quantum Dots for Color Conversion LEDs 彩色转换led固态荧光碳量子点的真空辅助合成

IF 3.7 3区化学

ACS Omega Pub Date : 2025-04-11 DOI: 10.1021/acsomega.5c0104710.1021/acsomega.5c01047

Hikmet Altintas, and , Kevser Sahin Tiras*,

{"title":"Vacuum-Assisted Synthesis of Solid-State Fluorescent Carbon Quantum Dots for Color Conversion LEDs","authors":"Hikmet Altintas,  and , Kevser Sahin Tiras*, ","doi":"10.1021/acsomega.5c0104710.1021/acsomega.5c01047","DOIUrl":"https://doi.org/10.1021/acsomega.5c01047https://doi.org/10.1021/acsomega.5c01047","url":null,"abstract":"Carbon dots (CDs) are one of the most promising nanomaterials with tunable optical properties and very good biocompatibility, opening wide perspectives in sensing, imaging, and optoelectronic applications. However, fluorescent CDs in powder form that are both adjustable and effective remain a significant issue. Here, we describe a simple, quick, and scalable process for creating solid-state green-emissive CDs using urea and trisodium citrate dihydrate with boric acid as a matrix and no dispersion solvent. The process employs a vacuum-assisted synthesis method, which enhances the molecular interaction between the precursors and ensures uniform dispersion, significantly improving the quality and stability of the final product. CDs embedded in a boric acid matrix (B-CDs) exhibit a photoluminescence quantum yield (PLQY) with a nearly 18% decrease when transitioning from aqueous solution to solid-state films. In contrast, CDs without the boric acid matrix display a significantly lower PLQY in aqueous form and no luminescence in the solid state, highlighting the enhancing effect of the boric acid matrix. By effectively reducing the aggregation-induced quenching, the boric acid matrix’s spatial confinement is thought to cause this rise in fluorescence. The resulting B-CD powders exhibit adjustable CIE coordinates and have been used to fabricate color-conversion light-emitting devices on UV chips. The current study presents a viable and scalable approach to solid-state fluorescent CDs that are very stable and efficient. These CDs will find extensive potential use in luminescent devices based on CDs, ranging from flexible lighting systems to color conversion, opening a new era of possibilities.","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 15","pages":"15654–15662 15654–15662"},"PeriodicalIF":3.7,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.5c01047","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biosynthesis of Phosphorus Nanoparticles for Sustainable Agroecosystems: Next Generation Nanotechnology Application for Improved Plant Growth 可持续农业生态系统中磷纳米粒子的生物合成：下一代纳米技术在改善植物生长中的应用

IF 3.7 3区化学

ACS Omega Pub Date : 2025-04-11 DOI: 10.1021/acsomega.5c0108210.1021/acsomega.5c01082

D P Krishna Samal, Lala Behari Sukla* and Ajit Kumar Bishoyi,

{"title":"Biosynthesis of Phosphorus Nanoparticles for Sustainable Agroecosystems: Next Generation Nanotechnology Application for Improved Plant Growth","authors":"D P Krishna Samal, Lala Behari Sukla* and Ajit Kumar Bishoyi, ","doi":"10.1021/acsomega.5c0108210.1021/acsomega.5c01082","DOIUrl":"https://doi.org/10.1021/acsomega.5c01082https://doi.org/10.1021/acsomega.5c01082","url":null,"abstract":"The rising global food demand needs novel approaches to increasing agricultural yield while minimizing environmental effect. Phosphorus (P) is important for almost all the physiological and biochemical processes in plants. However, the phosphorus availability in soil is limited in soil due to fixation. Excess application of phosphorus-based fertilizers causes environmental hazards like eutrophication, soil degradation, damage to the aquatic ecosystem, and groundwater pollution. One of the most remarkable approaches to counter these issues could be an application of nanotechnology with special regard to nano application of phosphorus nano particles. Phosphorus nanoparticles are expected to enhance phosphorus bioavailability, thereby improving nutrient-use efficiency. These nanoscale fertilizers facilitate controlled released of phosphorus, improved plant growth, germination, and increased crop yield. Other benefits include reduced use of conventional fertilizers, therefore preventing environmental degradation in conjunction with supporting the cause of sustainable agriculture. Despite these potential benefits limited research has explored the detailed application of phosphorus nanoparticles in agriculture. This review has embarked upon the synthesis, sources, and interaction of phosphorus nanoparticles with plants, by highlighting their potential in improving seed germination, crop yield, and bioremediation. Various sources of phosphorus nanoparticles are discussed and their eco-microbiological advantages examined. The introduction of phosphorus nanoparticles in agricultural practices can be a transformative step toward a cost-effective and sustainable agroecosystem.","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 15","pages":"14555–14565 14555–14565"},"PeriodicalIF":3.7,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.5c01082","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhalable TPGS/DPPC Micelles Coloaded with Curcumin and Icariin for Targeted Lung Cancer Therapy 吸入式 TPGS/DPPC 胶束添加姜黄素和淫羊藿苷，用于肺癌靶向治疗

IF 3.7 3区化学

ACS Omega Pub Date : 2025-04-11 DOI: 10.1021/acsomega.5c0000810.1021/acsomega.5c00008

Chengwei Jiang, Rongjun Bai and Satyanarayana Somavarapu*,

{"title":"Inhalable TPGS/DPPC Micelles Coloaded with Curcumin and Icariin for Targeted Lung Cancer Therapy","authors":"Chengwei Jiang, Rongjun Bai and Satyanarayana Somavarapu*, ","doi":"10.1021/acsomega.5c0000810.1021/acsomega.5c00008","DOIUrl":"https://doi.org/10.1021/acsomega.5c00008https://doi.org/10.1021/acsomega.5c00008","url":null,"abstract":"Lung cancer, particularly NSCLC, poses a major therapeutic challenge due to drug resistance and the poor aqueous solubility of chemotherapeutic agents, limiting treatment efficacy. This study investigates inhalable micelles for the codelivery of curcumin (CUR) and icariin (ICA), two hydrophobic bioactive compounds with anticancer potential, as a targeted therapeutic approach for NSCLC. The optimized micellar formulation (9:1 TPGS/DPPC) yielded nanomicelles (∼18 nm) with high encapsulation efficiency (∼90%) and a zeta potential of −1.24 mV, demonstrating stability for pulmonary administration. In vitro cytotoxicity studies demonstrated enhanced anticancer activity of CUR- and ICA-loaded micelles against A549 lung cancer cells (IC50 = 3.0 μg/mL), lower than doxorubicin (30 μg/mL), suggesting enhanced cytotoxic potential. Additionally, DPPH assays confirmed that encapsulation preserved curcumin’s functionality. Aerosolization studies demonstrated a high fine particle fraction (67 ± 3%) and emitted fraction (95 ± 1.0%), confirming the micelles’ suitability for deep lung deposition and effective pulmonary drug delivery. These findings highlight the potential of CUR- and ICA-loaded micelles as an inhalable NSCLC treatment, requiring further preclinical investigation.","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 15","pages":"15400–15411 15400–15411"},"PeriodicalIF":3.7,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.5c00008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of TiO2 Particle Size on the Synthesis of Titanium–Niobium Oxides and Their Electrochemical Performance in Lithium–Ion Cells TiO2粒径对钛铌氧化物合成及其在锂离子电池中电化学性能的影响

IF 3.7 3区化学

ACS Omega Pub Date : 2025-04-11 DOI: 10.1021/acsomega.5c0144710.1021/acsomega.5c01447

Zhongmeng Xue, Tao Li, He Sun, Qiwei Tang, Yang Yu* and Kunlei Zhu*,

{"title":"Influence of TiO2 Particle Size on the Synthesis of Titanium–Niobium Oxides and Their Electrochemical Performance in Lithium–Ion Cells","authors":"Zhongmeng Xue, Tao Li, He Sun, Qiwei Tang, Yang Yu* and Kunlei Zhu*, ","doi":"10.1021/acsomega.5c0144710.1021/acsomega.5c01447","DOIUrl":"https://doi.org/10.1021/acsomega.5c01447https://doi.org/10.1021/acsomega.5c01447","url":null,"abstract":"Developing high-performance anode materials is crucial for advancing lithium-ion batteries, particularly to meet the growing demands for higher capacity, improved safety, and enhanced rate performance in applications such as electric vehicles. In this study, we reveal the significant impact of the TiO2 particle size on the synthesis and electrochemical performance of titanium–niobium oxides (TNOs). Using a high-temperature solid-phase method, we synthesized TNOs with varying compositions and sizes by reacting TiO2 particles of different sizes (5–10, 10–25, 30, 60, and 100 nm) with Nb2O5 particles. Comprehensive characterization through X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and electrochemical tests revealed that the TNO synthesized using 10–25 nm TiO2 particles (designated as TNO4) exhibited superior electrochemical performance. TNO4 demonstrated the highest charge/discharge capacities at high current densities and exceptional cycling stability, which can be attributed to its optimal composition and particle size, both of which facilitate efficient lithium-ion diffusion and electron transport. This work not only highlights the critical role of precursor particle size in tailoring the properties of TNO anode materials but also identifies the optimal TiO2 particle size for synthesizing high-performance TNOs via a simple and scalable method. Additionally, this work underscores that both the composition and the particle size of TNOs significantly affect their electrochemical performance. Our findings provide valuable insights and serve as a practical reference for the design and preparation of advanced anode materials for lithium-ion batteries.","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 15","pages":"15744–15752 15744–15752"},"PeriodicalIF":3.7,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.5c01447","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0