ACS Omega最新文献

{"title":"AILDE Computer-Aided Discovery of Novel Ibuprofen–Coumarin Antitumor Lead Compounds Targeting Cyclooxygenase-2","authors":"Fengxu Wu, Tianshuai Wang, Xiaoyu Tang, Sirui Dong, Lun Luo, Chao Luo, Junkai Ma, Yanggen Hu","doi":"10.1021/acsomega.4c06596","DOIUrl":"https://doi.org/10.1021/acsomega.4c06596","url":null,"abstract":"Starting from three ibuprofen–coumarin hit compounds, we designed 18 derivative compounds targeting cyclooxygenase-2 (COX-2) by introducing different substituents onto them by using the computational auto in silico ligand directing evolution (AILDE) method. After synthesizing and testing the activity, we found that 6 representative compounds have micromolar enzyme inhibitory activity against COX-2. Additionally, 16 compounds have shown certain inhibitory activity in cervical cancer cells. Among these compounds, <b>6c</b> (IC₅₀ = 0.606 μM, HeLa) and <b>7g</b> (IC₅₀ = 0.783 μM, HeLa) have exhibited excellent activity, which is approximately 10 times better than the commercial drug gefitinib. According to molecular simulation results, the halogen atoms of <b>6c</b> and <b>7g</b> on the coumarin ring can form halogen bonds with COX-2, which significantly improves their activity compared to their hit compounds <b>6a</b> and <b>7a</b>. However, the key interactions were lost in binding with COX-1. The calculation results revealed that the two compounds are selective COX-2 inhibitors, with potential selectivity indexes of 6-fold and 5-fold, respectively. The cell-based activity of compounds <b>6c</b> and <b>7g</b> toward HEK293 cells demonstrates that our compounds possess an acceptable safety toward normal cells. The results indicate that <b>6c</b> and <b>7g</b> can serve as potential lead compounds for further lucubrate.","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":null,"pages":null},"PeriodicalIF":4.1,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142254338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response Patterns of Acoustic Wave Characteristics to Reservoir Petrophysical Parameters in Different Bedding Directions: A Case Study of Low- and Middle-Rank Coals in Xinjiang, China","authors":"Liang Du, Chao Jia, Haichao Wang, Pichen Sun, Yifan Chen, Hongmei Su, Chuanjian Cheng, Xuchao Huang, Zhengshuai Wang, Peng Lai, Bo Wang, Zhenpeng Hu","doi":"10.1021/acsomega.4c05176","DOIUrl":"https://doi.org/10.1021/acsomega.4c05176","url":null,"abstract":"The physical properties of coal reservoirs, important parameters for evaluating the production potential of coalbed methane (CBM) resources, can be assessed nondestructively and in real-time using acoustic wave technology. In this study, we collected 48 low- and middle-rank coal samples oriented in different bedding directions from seven typical coal mines, encompassing the Zhunan, Tuha, and Kuqa-Bay coalfields in Xinjiang, China. We clarified the characteristics of the physical parameters (apparent density, fracture, porosity, and permeability) and acoustic wave of coal variations through acoustic wave, porosity, and permeability experiments, revealing the response law of acoustic wave characteristics to the physical parameters of coal. The results indicated that the acoustic wave velocity and dynamic elastic modulus (<i>E</i>_d) of coal samples oriented in the perpendicular bedding direction are larger than those oriented in the parallel bedding direction; however, the dynamic Poisson’s ratio (μ_d) of coal samples oriented in different bedding directions does not significantly differ. The existence of fractures significantly reduces the acoustic wave velocity and <i>E</i>_d of the coal. The greater the apparent density of coal, the tighter its structure, resulting in a faster acoustic wave velocity. The larger the porosity of coal, the greater its internal voids, leading to a more pronounced attenuation of acoustic energy and a slower acoustic wave velocity. The more developed and interconnected the bedding fractures of coal bodies oriented in the parallel bedding direction, the higher their permeability, resulting in a smaller decrease in acoustic wave velocity. Conversely, the more developed the bedding fractures of coal bodies oriented in the perpendicular bedding direction, the more pronounced their attenuation of acoustic wave velocity. Finally, the regression equations for <i>E</i>_d with the square of P-wave velocity (<i>V</i>_P²) and μ_d with the square ratio of <i>V</i>_P to S-wave velocity (<i>V</i>_P²/<i>V</i>_S²) were established for coal. The study findings can help evaluate and predict the reservoir quality of coal seams, assess CBM, and improve the safety and efficiency of its extraction.","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":null,"pages":null},"PeriodicalIF":4.1,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142254334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of the Quantitative Property–Consequence Relationship Model for Prediction of Hydrogen Leakage and Dispersion Using Response Surface Method and Artificial Neural Network Approaches","authors":"Junseo Lee, Sehyeon Oh, Seongheon Baek, Changbock Chung, Byungchol Ma","doi":"10.1021/acsomega.4c05841","DOIUrl":"https://doi.org/10.1021/acsomega.4c05841","url":null,"abstract":"Hydrogen, an environmentally friendly and highly regarded future energy source, can form flammable vapor clouds upon leakage, which may transition into explosion. Predicting the dispersion behavior of hydrogen is crucial for preventing such incidents. This study aims to develop a quantitative property–consequence relationship (QPCR) model using the response surface method (RSM) and artificial neural network (ANN) to swiftly and accurately predict dispersion behavior. Initially, 8 variables were defined from source and dispersion models, constructing a data set through 6,561 PHAST simulations. Subsequently, the RSM-BBD (Box-Behnken design) and ANN-BPNN (Backpropagation neural network) models were developed, alongside a hybrid model incorporating BPNN after excluding four low-influence variables based on analysis of variance (ANOVA). All models achieved an R² value exceeding 0.99. The hybrid model notably reduced computational costs by 97% compared to ANN-BPNN and exhibited lower mean square error (MSE). These results introduce a cost-effective approach for high-accuracy QPCR modeling and highlight the viability of diverse statistical methods.","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":null,"pages":null},"PeriodicalIF":4.1,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142254335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Pharmacokinetics and Tissue Distribution of Hexahydrocurcumin Following Intraperitoneal vs Oral Administration in Mice Using LC-MS/MS","authors":"Worawut Chaiyasaeng, Darunee Hongwiset, Chainarong Tocharus, Baralee Punyawudho, Jiraporn Tocharus, Waraluck Chaichompoo, Pornchai Rojsitthisak, Wachirachai Pabuprapap, Boon-ek Yingyongnarongkul, Apichart Suksamrarn","doi":"10.1021/acsomega.4c06604","DOIUrl":"https://doi.org/10.1021/acsomega.4c06604","url":null,"abstract":"A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated to determine hexahydrocurcumin (HHC) levels in mouse plasma, brain, liver, and kidneys using a negative ion mode electrospray ionization (ESI) source. Demonstrating a lower limit of quantification (LLOQ) of 5 ng/mL, the method showed excellent linearity across a concentration range of 5–500 ng/mL in all tested matrices. Precision evaluations reported a coefficient of variation (CV%) of less than 13.19% for both intraday and interday measurements, while accuracy ranged from 95.13 to 105.07% across all quality control levels. HHC extraction recovery was consistently observed between 70.18 and 93.28%, with a CV% deviation of less than 15%. In the pharmacokinetic evaluation of HHC in mice following a single intraperitoneal (IP) or oral administration, a noncompartment analysis was utilized. After IP administration (40 mg/kg), the <i>C</i>_max value was 47.90 times higher than that achieved via oral administration. Peak plasma concentrations were observed approximately 5 min post-IP and 15 min post-oral dosing. The observed half-lives after these administrations were approximately 1.52 and 2.17 h for IP and oral routes, respectively. Oral administration revealed a relative bioavailability of only 12.28% compared with the IP route. Furthermore, following IP administration, the half-life values in brain, liver, and kidney were not significantly different but more than the half-life value found in plasma. The liver and kidney exhibited the highest concentrations of HHC, while the brain showed the least, suggesting that the hydrophobic nature of HHC impedes its passage through the blood–brain barrier. This study is the first to provide detailed insights into the pharmacokinetics and tissue distribution characteristics of HHC following oral and IP administration in mice, setting the stage for further focus on HHC as a potential new drug candidate.","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":null,"pages":null},"PeriodicalIF":4.1,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142254062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymer-Based Extracting Materials in the Green Recycling of Rare Earth Elements: A Review","authors":"Charles F. Croft, Edward A. Nagul, M. Inês G. S. Almeida, Spas D. Kolev","doi":"10.1021/acsomega.4c06990","DOIUrl":"https://doi.org/10.1021/acsomega.4c06990","url":null,"abstract":"Rare earth elements (REEs) are becoming increasingly important in the development of modern and green energy technologies with the demand for REEs predicted to grow in the foreseeable future. The importance of REEs lies in their unique physiochemical properties, which cannot be reproduced using other elements. REEs are sourced through mining, with global exploration of additional commercially viable mining sites still ongoing. However, there is a growing need for recycling of REEs due to the current supply of REEs not matching the growing demand, the environmental impact of REE mining and processing (the so-called “balance problem”), and the generation of large volumes of harmful electronic waste (e-waste). Industrial REE processing is mainly carried out by hydrometallurgy processes, particularly solvent extraction (SX) and ion exchange (IX) technologies. However, these methods have a significant environmental impact due to their intensive use of harmful and nonsustainable reagents. This Review highlights the development of approaches involving polymer-based extracting materials for REE manufacturing as more sustainable alternatives to current industrial REE processing methods. These materials include supported liquid membranes (SLMs), solvent impregnated resins (SIRs), macro and micro capsules, polymer inclusion membranes (PIMs), and micro polymer inclusion beads (μPIBs). Polymer-based extracting materials have the advantage of more economical regent usage while applying the same extractants used in commercial SX, enabling applications analogous to the current industrial process. These materials can be fabricated by a variety of methods in a diverse range of physical formats, with the advantages and disadvantages of each material type described and discussed in this Review along with their applications to REE processing, including e-waste recycling and mineral processing.","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":null,"pages":null},"PeriodicalIF":4.1,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142254339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soluplus–TPGS Mixed Micelles as a Delivery System for Brigatinib: Characterization and In Vitro Evaluation","authors":"Raisuddin Ali, Wajhul Qamar, Mohd Abul Kalam, Ziyad Binkhathlan","doi":"10.1021/acsomega.4c06264","DOIUrl":"https://doi.org/10.1021/acsomega.4c06264","url":null,"abstract":"Lung cancer is a major public health concern, with a high incidence and fatality rate. Its treatment is very difficult, as it is mostly diagnosed in advanced stages. Non-small cell lung carcinoma (NSCLC) is the major form of lung carcinoma that persists. Brigatinib (BGT), a powerful small-molecule tyrosine kinase inhibitor, has demonstrated significant therapeutic potential in the treatment of NSCLC with anaplastic lymphoma kinase (ALK) mutations. However, the therapeutic applicability of BGT is hampered by its low solubility and bioavailability. In this study, we developed a mixed micelle system comprising Soluplus and TPGS loaded with BGT. BGT was encapsulated into the mixed micelles using various combinations of Soluplus and TPGS, with encapsulation efficiency (EE%) ranging from 52.43 ± 1.07 to 97.88 ± 2.25%. The dynamic light scattering data showed that the mixed micelles ranged in size from 75.7 ± 0.46 to 204.3 ± 5.40 nm. The selected mixed micelles (F6) showed approximately 38% BGT release in the first 2 h, and subsequently, within 72 h, the release was 94.50 ± 5.90%. The NMR experiment confirmed the formation of micelles. Additionally, the mixed micelles showed significantly higher cellular uptake (<i>p</i> &lt; 0.05) and increased cytotoxicity (<i>p</i> &lt; 0.05) as compared to the free BGT. Specifically, the obtained IC₅₀ values for BGT-loaded Soluplus–TPGS mixed micelles and free BGT were 22.59 ± 6.07 and 61.45 ± 6.35 μg/mL, respectively. The results of the in vitro stability experiment showed that the selected mixed micelle (F6) was stable at both room temperature and 4 °C, with only minor changes in size and PDI. Our results indicate great potential for the developed Soluplus–TPGS mixed micelles as a delivery system for BGT.","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":null,"pages":null},"PeriodicalIF":4.1,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142254337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Action of Molybdate Anion on d-Glucosone: Catalytic Conversion to Aldonates Involving C1–C2 Transposition","authors":"Wenhui Zhang, Anthony S. Serianni","doi":"10.1021/acsomega.4c04139","DOIUrl":"https://doi.org/10.1021/acsomega.4c04139","url":null,"abstract":"Treatment of the osone (aldos-2-ulose), <span>d</span>-[1-¹³C]glucosone (<b>1</b>¹), with sodium molybdate at 90° for 30 h gave a mixture of <span>d</span>-[2-¹³C]gluconate (<b>2</b>²) and <span>d</span>-[2-¹³C]mannonate (<b>3</b>²) in an 85:15 ratio, indicating that the reaction proceeds with C1–C2 transposition similar to that observed previously with aldoses. Reactions with several singly and doubly ¹³C-labeled isotopomers of <b>1</b> confirmed this transposition. In contrast to the aldose reaction, the reaction with <b>1</b> is irreversible, presumably due to electrostatic repulsion between the negatively charged catalytically active bimolybdate species and the negatively charged aldonate product. The production of <b>2</b> and <b>3</b> is mediated by the formation of two structurally distinct bimolybdate complexes, one producing the <i>gluco</i> isomer and the other producing the <i>manno</i> isomer. Reaction byproducts were also observed, specifically <span>d</span>-[1-¹³C]arabinose (<b>4</b>¹) and [¹³C]formate (<b>5</b>), when <b>1</b>¹ was used as the reactant. These byproducts appear to form from the breakdown of bimolybdate complexes via alternative pathways that compete with those responsible for aldonate formation.","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":null,"pages":null},"PeriodicalIF":4.1,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142254340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on the Remaining Useful Life Prediction Method of Energy Storage Battery Based on Multimodel Integration","authors":"Lei Shao, Liangqi Zhao, Hongli Liu, Delong Zhang, Ji Li, Chao Li","doi":"10.1021/acsomega.4c03524","DOIUrl":"https://doi.org/10.1021/acsomega.4c03524","url":null,"abstract":"The remaining useful life (RUL) of lithium-ion batteries (LIBs) needs to be accurately predicted to enhance equipment safety and battery management system design. Currently, a single machine learning approach (including an improved machine learning approach) has poor generalization performance due to stochasticity, and the combined prediction approach lacks sufficient theoretical support at the same time. In this paper, we first analyze the prediction principles and applicability of models such as long and short-term memory networks and random forests, and then propose a method for predicting the RUL of batteries based on the integration of multiple-model, and finally validate the proposed model by using experimental data. The experimental results show that (1) for the proposed model, in the best case, the root-mean-square error (RMSE) does not exceed 0.14%, which has a stronger generalization; (2) for the comparison with the single model used, the average RMSE is reduced by 46.2%, 43.7%, and 80.6%, which has a better fitting performance. These results show that the model has good prediction accuracy and application prospects for predicting the RUL of energy storage batteries.","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":null,"pages":null},"PeriodicalIF":4.1,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142254329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visualization Experimental Investigation on Flow Regulation and Oil Displacement Characteristics of Gel Foam in Fractured-Vuggy Carbonate Reservoirs","authors":"Yingda Yang, Gen Rong, Yan Xin, Yongjin Song, Binfei Li","doi":"10.1021/acsomega.4c05686","DOIUrl":"https://doi.org/10.1021/acsomega.4c05686","url":null,"abstract":"Fractured-vuggy reservoirs experience severe channeling during water and gas injection operations, and conventional foam shows weak regeneration capabilities in large-scale fracture spaces, thus failing to effectively seal them. Gel foam combines the advantages of both foam and gel, significantly enhancing the foam’s stability and showing good suitability in fractured-vuggy reservoirs. In this article, the plugging and flow regulation properties of gel foam in fractures were studied through fracture displacement experiments. The dynamic plugging capability of gel foam was superior to that of ordinary foam, and its plugging effect was significantly influenced by the fracture opening. Gel foam had strong retention capacity in fractures, and after plugging large-opening fractures, the diversion rate of small-opening fractures was increased by at least 83.3 times during subsequent parallel water flooding, making the flow regulation effect remarkable. Through the oil displacement experiments in typical fractured-vuggy models, the profile control law and enhanced oil recovery performance of gel foam under different fractured-vuggy structures were studied. In the regular fractured-vuggy network, gel foam adhered to occupy the fractured-vuggy space for plugging and controlled the top gas migration direction to synergistically drive the recovery of remaining oil, ultimately achieving a recovery of 95%. In the combination of fractures and irregular vugs, due to the density, gel foam continuously pushed down and right along the fractures to the vugs, pushing the crude oil and formation water in the vugs to migrate to the production well. The recovery of the gel foam flooding stage was as high as 48%, and the final recovery reached 93.5; only a small amount of shielded remaining oil was difficult to drive. The research results are of great significance to the application of gel foam in enhancing oil recovery in fractured-vuggy reservoirs.","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":null,"pages":null},"PeriodicalIF":4.1,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142254333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elucidating the Photophysics and Nonlinear Optical Properties of a Novel Azo Prototype for Possible Photonic Applications: A Quantum Chemical Analysis","authors":"Sàvio Fonseca, Neidy S. S. dos Santos, Herbert C. Georg, Tertius L. Fonseca, Patricio F. Provasi, Kaline Coutinho, Sylvio Canuto, Antônio R. da Cunha, Rodrigo Gester","doi":"10.1021/acsomega.4c04240","DOIUrl":"https://doi.org/10.1021/acsomega.4c04240","url":null,"abstract":"The photophysics and nonlinear optical responses of a novel nitrothiazol-methoxyphenol molecule were investigated using density functional theory (DFT) and time-dependent density functional theory (TD-DFT) methods with the polarizable continuum model to take the solvent effect into account. Special attention is paid to the description of the lowest absorption band, characterized as a strong π → π* state in the visible region of the spectrum. The TD-DFT emission spectrum analysis reveals a significant Stokes shift of more than 120 nm for the π → π* state in gas phase condition. The results show a great influence of the solvent polarity on the nonlinear optical (NLO) response of the molecule. Specifically, the second harmonic generation hyperpolarizability β(−2ω; ω, ω) shows a large variation from gas to aqueous solvent (82 × 10^–30 to 162 × 10^–30 esu), exhibiting notably higher values than those reported for standard compounds such as urea (0.34 × 10^–30 esu) and <i>p</i>-nitroaniline (6.42 × 10^–30 esu). Furthermore, a two-photon absorption analysis indicates a large cross-section (δ^2PA = 77 GM) with superior performance compared to several dyes. These results make the molecule quite interesting for nonlinear optics.","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":null,"pages":null},"PeriodicalIF":4.1,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142254332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}