ACS Omega最新文献

{"title":"Evolving Landscape of Parkinson's Disease Research: Challenges and Perspectives.","authors":"Rumiana Tenchov, Janet M Sasso, Qiongqiong Angela Zhou","doi":"10.1021/acsomega.4c09114","DOIUrl":"10.1021/acsomega.4c09114","url":null,"abstract":"<p><p>Parkinson's disease (PD) is a progressive neurodegenerative disorder that primarily affects movement. It occurs due to a gradual deficit of dopamine-producing brain cells, particularly in the substantia nigra. The precise etiology of PD is not fully understood, but it likely involves a combination of genetic and environmental factors. The therapies available at present alleviate symptoms but do not stop the disease's advancement. Research endeavors are currently directed at inventing disease-controlling therapies that aim at the inherent mechanisms of PD. PD biomarker breakthroughs hold enormous potential: earlier diagnosis, better monitoring, and targeted treatment based on individual response could significantly improve patient outcomes and ease the burden of this disease. PD research is an active and evolving field, focusing on understanding disease mechanisms, identifying biomarkers, developing new treatments, and improving care. In this report, we explore data from the CAS Content Collection to outline the research progress in PD. We analyze the publication landscape to offer perspective into the latest expertise advancements. Key emerging concepts are reviewed and strategies to fight disease evaluated. Pharmacological targets, genetic risk factors, as well as comorbid diseases are explored, and clinical usage of products against PD with their production pipelines and trials for drug repurposing are examined. This review aims to offer a comprehensive overview of the advancing landscape of the current understanding about PD, to define challenges, and to assess growth prospects to stimulate efforts in battling the disease.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 2","pages":"1864-1892"},"PeriodicalIF":3.7,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"UVREK: Development and Analysis of an Expression Profile Knowledgebase of Biomolecules Induced by Ultraviolet Radiation Exposure.","authors":"Shanmuga Priya Baskaran, Janani Ravichandran, Priya Shree, Vinayak Thengumthottathil, Bagavathy Shanmugam Karthikeyan, Areejit Samal","doi":"10.1021/acsomega.4c06708","DOIUrl":"10.1021/acsomega.4c06708","url":null,"abstract":"<p><p>Humans encounter diverse environmental factors which can have impact on their health. One such environmental factor is ultraviolet (UV) radiation, which is part of the physical component of the exposome. UV radiation is the leading cause of skin cancer and is a significant global health concern. A large body of published research has been conducted to uncover the mechanisms underlying the adverse outcomes of UV radiation exposure on living beings. These studies involve identifying the biomolecules induced upon UV radiation exposure. A few previous efforts have attempted to compile this information in the form of a database, but such earlier efforts have certain limitations. To fill this gap, we present a structured database named UVREK (<b>U</b>ltra<b>V</b>iolet <b>R</b>adiation <b>E</b>xpression <b>K</b>nowledgebase), containing manually curated data on biomolecules induced by UV radiation exposure from the published literature. UVREK has compiled information on 985 genes, 470 proteins, 54 metabolites, and 77 miRNAs along with their metadata. Thereafter, an enrichment analysis performed on the human gene set of the UVREK database showed the importance of transcription-related processes in UV-related response and enrichment of pathways involved in cancer and aging. While significantly contributing toward characterizing the physical component of the exposome, we expect that the compiled data in UVREK will serve as a valuable resource for the development of better UV protection mechanisms such as UV sensors and sunscreens. Noteworthily, UVREK is the only resource to date compiling varied types of biomolecular responses to UV radiation with the corresponding metadata. UVREK is openly accessible at https://cb.imsc.res.in/uvrek/.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 2","pages":"1927-1942"},"PeriodicalIF":3.7,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, Characterization, and Antimicrobial Activity of Urea-Containing α/β Hybrid Peptides against <i>Pseudomonas aeruginosa</i> and Methicillin-Resistant <i>Staphylococcus aureus</i>.","authors":"Shifa Firdous, Aminur Rahman Sarkar, Rakshit Manhas, Rubina Chowdhary, Arti Rathore, Jyoti Kumari, Rajkishor Rai, Avisek Mahapa","doi":"10.1021/acsomega.4c08680","DOIUrl":"10.1021/acsomega.4c08680","url":null,"abstract":"<p><p>The insertion of β-amino acids and replacement of the amide bond with a urea bond in antimicrobial peptide sequences are promising approaches to enhance the antibacterial activity and improve proteolytic stability. Herein, we describe the synthesis, characterization, and antibacterial activity of short αβ cationic hybrid peptides LA^U-Orn-β^3,3Ac₆c-PEA, <b>DY-01</b>; LA^U-Lys-β^3,3Ac₆c-PEA, <b>DY-02</b>; and LA^U-Arg-β^3,3Ac₆c-PEA, <b>DY-03</b> in which a C12 lipid chain is conjugated at the N terminus of peptide through urea bonds. Further, we evaluated all the peptides against both <i>Pseudomonas aeruginosa</i> and methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) and their multidrug resistant (MDR) clinical isolates. All of the peptides exhibited significant bactericidal efficacy with minimal inhibitory concentration (MIC) values ranging from 2.5 to 6.25 μM (1.4 to 3.9 μg/mL) against <i>P. aeruginosa</i> and its MDR clinical isolates, whereas the MIC values ranging from 0.78 to 6.25 μM (0.45 to 3.9 μg/mL) against MRSA and MDR clinical isolates of <i>S. aureus</i>. To understand the potency and mechanism of action of <b>DY-01</b> to <b>DY-03</b>, time-kill kinetics, biofilm inhibition and disruption, synergistic interactions with standard antibiotics, swarming motility, scanning electron microscopy (SEM) analyses, and ex vivo infection assay were performed. The SEM images revealed that all of the peptides exert antibacterial activity through a membrane disruption mechanism. Additionally, negligible cytotoxicity was observed against mammalian cell lines RAW 264.7 and J774A.1, with mild hemolysis at higher concentrations. The comprehensive antimicrobial assessments of <b>DY-01</b> to <b>DY-03</b> against <i>P. aeruginosa</i> and MRSA highlight their potential for clinical applications in combating resistant microbial infections.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 2","pages":"2102-2115"},"PeriodicalIF":3.7,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transient Expression of Zika NS2B Protein Antigen in <i>Nicotiana benthamiana</i> and Use for Arboviruses Diagnosis.","authors":"Mario A M Herazo, Daylana R S Dantas, Bruno B Silva, Helen P S Costa, Eduarda N F N Santos, Luiz F W G Moura, João X S Neto, Maurício F Van Tilburg, Eridan O P T Florean, Arlindo A Moura, Maria I F Guedes","doi":"10.1021/acsomega.4c08998","DOIUrl":"10.1021/acsomega.4c08998","url":null,"abstract":"<p><p>Zika (ZIKV) and Dengue (DENV) viruses are clinically significant due to their severe neurological and hemorrhagic complications. Rapid diagnostics often rely on nonstructural proteins to generate specific antibodies. This study aimed to produce IgG antibodies from the recombinant ZIKV protein and plant-expressed NS2B protein for arbovirus detection in serum and urine samples. The NS2B protein was expressed in <i>Nicotiana benthamiana</i> and purified chromatographically. Validation of recombinant NS2B as an antigen in indirect immunoassays demonstrated 95% sensitivity and 100% specificity in IgM/IgG ELISA tests, enabling effective detection of ZIKV and DENV. Notably, r-ZIKV-NS2B IgG identified positive ZIKV and DENV cases in urine but failed to detect negatives, suggesting limitations in specificity for urine diagnostics. Using urine as a diagnostic medium offers a less invasive and more practical approach, broadening the test applicability. This study utilized patient-derived positive urine samples and healthy samples spiked with an exogenous virus. Findings highlight the potential of the ZIKV-NS2B protein as a robust antigen for arbovirus diagnosis and demonstrate the viability of plant-based systems for antigen production, advancing diagnostics for neglected tropical diseases.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 2","pages":"2184-2196"},"PeriodicalIF":3.7,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly Green Fluorescent Carbon Dots from Gallic Acid: A Turn-On Sensor toward Pb²⁺ Ions.","authors":"Hardeep Kaur, Monika Bhattu, Subhendu Chakroborty, Manpreet Kaur Aulakh, Vishal Mutreja, Meenakshi Verma, Karunesh Tiwari, Chandra Chakraborty, Ibrahim A Darwish","doi":"10.1021/acsomega.4c10796","DOIUrl":"10.1021/acsomega.4c10796","url":null,"abstract":"<p><p>Carbon dots (CDs) are emerging novel fluorescent sensing nanomaterials owing to their tunable optical properties, biocompatibility, and eco-friendliness. Herein, we report a facile one-pot hydrothermal route for the synthesis of highly green fluorescent CDs using gallic acid (GA) as a single carbon source in <i>N</i>,<i>N</i>-dimethylformamide (DMF) solvent, which serves as a nitrogen source and reaction medium. The optical properties of the synthesized GA-DMF CDs were systematically characterized by using UV-vis and photoluminescence spectroscopy, revealing strong green fluorescence. Further, to gain insights into their size and structural, elemental, and chemical composition, Fourier transform infrared, dynamic light scattering, high-resolution transmission electron microscopy (HR-TEM), X-ray diffraction, and X-ray photoelectron spectroscopy characterization techniques were performed. HR-TEM analysis confirmed the formation of uniformly spherical GA-DMF CDs with an average particle size of 16 ± 6.1 nm. Notably, the GA-DMF CDs exhibited a highly selective and turn-on fluorescent response to Pb²⁺ ions in aqueous solutions, which was attributed to a chelation-enhanced fluorescence mechanism. The detection limit for Pb²⁺ ions was determined to be as low as 7.15 × 10^-7 M, with a broad linear detection range of 30-130 μM, underscoring their sensitivity and practical application in water quality monitoring. This study introduces a novel, sustainable approach for synthesizing nitrogen-doped CDs with outstanding optical properties and highlights their unprecedented selectivity toward Pb²⁺ ions, advancing the development of efficient and eco-friendly sensing platforms for heavy metal detection.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 2","pages":"2354-2363"},"PeriodicalIF":3.7,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practical Streamline Method for Quantitatively Characterizing Waterflooding in Narrow Channel Reservoirs.","authors":"Pin Jia, Yang Li, Bangdan Liu, Haoran Feng","doi":"10.1021/acsomega.4c08916","DOIUrl":"https://doi.org/10.1021/acsomega.4c08916","url":null,"abstract":"<p><p>In waterflooding development of narrow channel reservoirs, the water cut rises quickly, and the reservoir becomes nearly fully flooded, yet oil recovery remains low. The narrow strip sand body and long-term water injection create a complex oil and water distribution, making it difficult to evaluate the degree of reservoir utilization during waterflooding. This paper establishes a practical streamline method to quantitatively characterize the waterflooding mobilization degree of narrow channel reservoirs. The streamline method, based on the boundary element method, first characterizes the narrow channel reservoir with complex morphologies and calculates the pressure field. Then, the velocity field is determined, and the streamlines are tracked using the Euler method. The characteristic line method is adopted to solve the saturation equation along each streamline, resulting in the overall saturation distribution of the model. Compared to the stream-tube and numerical simulation methods, the practical streamline method has several advantages, including the automatic generation of flow paths, low calculation dimensions, fast calculation speed, and high calculation accuracy. The method accurately describes the complex boundaries of the channel, realizes the quantitative characterization of waterflooding mobilization degree partitioning, and clarifies the streamline patterns and oil-water flow processes. Finally, the method was applied to a typical narrow channel reservoir to quantitatively evaluate the waterflooding mobilization degree of a well group, resulting in reasonable development and adjustment suggestions. These findings provide guidance for development adjustments in similar types of narrow channel reservoirs.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 2","pages":"2167-2183"},"PeriodicalIF":3.7,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On Oscillations in the External Electrical Potential of Sea Urchins.","authors":"Panagiotis Mougkogiannis, Andrew Adamatzky","doi":"10.1021/acsomega.4c10277","DOIUrl":"10.1021/acsomega.4c10277","url":null,"abstract":"<p><p>Sea urchins display complex bioelectric activity patterns, even with their decentralized nervous system. Electrophysiological recordings showed distinct spiking patterns. The baseline potential was about 8.80 mV. It had transient spikes with amplitudes up to 21.05 mV. We observed many types of depolarization events. They included burst-like activity and prolonged state fluctuations lasting several seconds. Frequency domain analysis showed a power-law behavior. It had a scaling exponent of 6.21 ± 0.06, indicating critical dynamics. The analysis showed potential variations between 3.69 and 21.05 mV. The oscillation periods ranged from 4 to 3102 s. The varied timing of bioelectric signals suggests that these organisms can process information. This challenges traditional views of neural computation in simpler animals. These findings provide quantitative insights into the complex signaling mechanisms of the sea urchin's distributed nervous system.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 2","pages":"2327-2337"},"PeriodicalIF":3.7,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lanostane Triterpenes, Flavanones and Acetogenins from the Roots of <i>Uvaria siamensis</i> and Their Cytotoxic Activity.","authors":"Lueacha Tabtimmai, Kiattawee Choowongkomon, Prasat Kittakoop, Ratsami Lekphrom, Florian Thierry Schevenels, Supachai Jadsadajerm, Awat Wisetsai","doi":"10.1021/acsomega.4c09267","DOIUrl":"10.1021/acsomega.4c09267","url":null,"abstract":"<p><p>Our phytochemical investigation of the roots of <i>Uvaria siamensis</i> led to the isolation of two new lanostane triterpenes, 3-acetylpolycarpol (<b>1</b>) and 15-acetylpolycarpol (<b>2</b>), as well as 15 known compounds (<b>3</b>-<b>17</b>). The structures of the isolated compounds were elucidated by an analysis of spectroscopic data. Compounds <b>1</b>-<b>9</b> were tested against nonsmall cell lung cancer cells (A549) and human cervical carcinoma cells (HeLa) using an MTT assay. Polycarpol (<b>3</b>) and uvariamicin-II (<b>9</b>) exhibited potent cytotoxicity against A549 cancer cells, while 15-acetylpolycarpol (<b>2</b>) and pinocembrin (<b>4</b>) displayed potent cytotoxicity against HeLa cancer cells. Further analysis of the apoptosis-inducing properties revealed that uvariamicin-II (<b>9</b>) and pinocembrin (<b>4</b>) induced apoptosis in a dose-dependent manner in A549 and HeLa cells, respectively. These two compounds also showed weak cytotoxicity toward <i>Vero</i> cells.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 2","pages":"2253-2259"},"PeriodicalIF":3.7,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low Molecular Weight Biobased Aromatics from Pyrolysis Liquids Using Zeolites: Yield Improvements by Using Pyrolysis Oil Fractions.","authors":"Dian S Santosa, Leon Rohrbach, Hans Heeres, Robbie H Venderbosch, Andre Heeres, Hero J Heeres","doi":"10.1021/acsomega.4c03831","DOIUrl":"10.1021/acsomega.4c03831","url":null,"abstract":"<p><p>Pyrolysis liquids from lignocellulosic biomass have the potential to be used as a feed for aromatics such as benzene, toluene, and xylenes (BTX) using catalytic upgrading with zeolites. We here report an experimental study on the conversion of various pyrolysis oil fractions to determine the most suitable one for BTX synthesis. For this purpose, the pyrolysis liquid was fractionated using several extraction/distillation steps to give four fractions with different chemical compositions. The fractions were analyzed in detail using nuclear magnetic resonance spectroscopy, elemental analysis, gas chromatography-mass spectroscopy, thermogravimetric analysis, Karl-Fischer titration, and gel permeation chromatography. Catalytic pyrolysis experiments were carried out using a tandem microreactor with H-ZSM-5 (23) as the catalyst. The highest BTX yield of 24% (on a carbon and dry basis) was obtained using the fractions enriched in phenolics, whereas all others gave far lower yields (4.4-9%, on a carbon and dry basis). Correlations were established between the chemical composition of the feed fraction and the BTX yield. These findings support the concept of a pyrolysis biorefinery, where the pyrolysis liquid is separated into well-defined fractions before further dedicated catalytic conversions to biobased chemicals and biofuels using tailored catalysts.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 2","pages":"1901-1910"},"PeriodicalIF":3.7,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pickering Emulsions Stabilized by Hybrid TiO₂-pNIPAm Composites for the Photocatalytic Degradation of 4-Propylbenzoic Acid.","authors":"Zygimantas Gricius, Gisle Øye","doi":"10.1021/acsomega.4c07847","DOIUrl":"10.1021/acsomega.4c07847","url":null,"abstract":"<p><p>Pickering emulsions (PEs) have demonstrated significant potential in various fields, including catalysis, biomedical applications, and food science, with notable advancements in wastewater treatment through photocatalysis. This study explores the development and application of TiO₂-poly(<i>N</i>-isopropylacrylamide) (pNIPAm) composite gels as a novel framework for photocatalytic wastewater remediation. The research focuses on overcoming challenges associated with conventional nanoparticle-based photocatalytic systems, such as agglomeration and inefficient recovery of particles. By integrating TiO₂ nanoparticles into pNIPAm gels, we aimed to achieve high emulsion stability and photocatalytic efficiency while suppressing the effects of pNIPAm's volume phase transition temperature (VPTT) to facilitate effective emulsion recovery. The study involves the synthesis of TiO₂-pNIPAm composites with varying monomer-to-particle ratios, characterizing their VPTT behavior, morphology, and thermal stability. These composites were then evaluated for their emulsification properties, phase transition behavior, and photocatalytic activity in degrading 4-propylbenzoic acid, a model pollutant. The results highlight the effectiveness of the TiO₂-pNIPAm Pickering emulsions in wastewater treatment, offering improved stability and reusability compared to traditional dispersion-based systems. This work provides new insights into the design of composite materials for enhanced photocatalytic applications and demonstrates the potential of Pickering emulsions in sustainable environmental remediation.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 2","pages":"1988-2002"},"PeriodicalIF":3.7,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}