具有生物可及性和抗炎活性的负载大麻二酚纳米乳

IF 4.3 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

ACS Omega Pub Date : 2025-10-12 DOI:10.1021/acsomega.5c04608

Yuna Lee, , , Sang Hoon Kim, , , Ha-Yeon Song, , and , Eui-Baek Byun*,

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引用次数: 0

摘要

大麻二酚（CBD）的水溶性差，生物利用度低，限制了其治疗潜力，因此口服给药具有挑战性。在这项研究中，我们使用琥珀酸辛烯基（OSA）改性淀粉制备了一种负载cbd的水包油纳米乳液来解决这些问题。CBD-NE包封后粒径均匀（39.18±0.15 nm），包封效率高达99.80±0.13%，并在28 d内保持胶体稳定性。模拟胃肠道消化表明，CBD- ne中的CBD生物可及性高于未配制的CBD。此外，RAW264.7巨噬细胞体外实验显示，CBD-NE显著（p < 0.05）抑制脂多糖诱导的促炎细胞因子白介素-6和肿瘤坏死因子-α的分泌。总的来说，CBD-NE改善的生物可及性和强大的抗炎功效突出了其治疗和营养应用的潜力。

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Cannabidiol Loaded Nanoemulsion with Improved Bioaccessibility and Anti-Inflammatory Activity

Oral delivery of cannabidiol (CBD) is challenging because of its poor water solubility and low bioavailability, which restrict its therapeutic potential. In this study, we used a CBD-loaded oil-in-water nanoemulsion prepared from octenyl succinate anhydride (OSA)-modified starch to address these challenges. The CBD-encapsulated nanoemulsion (CBD-NE) exhibited a uniform particle size of 39.18 ± 0.15 nm, high encapsulation efficiency of 99.80 ± 0.13%, and maintained colloidal stability during storage for 28 days. Simulated gastrointestinal digestion demonstrated that the bioaccessibility of CBD in CBD-NE was higher than that in unformulated CBD. Furthermore, in vitro experiments using RAW264.7 macrophages showed that CBD-NE significantly (p < 0.05) suppressed lipopolysaccharide-induced secretion of the pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-α. Collectively, the improved bioaccessibility and potent anti-inflammatory efficacy of CBD-NE highlight its potential for therapeutic and nutraceutical applications.

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来源期刊

ACS Omega Chemical Engineering-General Chemical Engineering

CiteScore

6.60

自引率

4.90%

发文量

3945

审稿时长

2.4 months

期刊介绍： ACS Omega is an open-access global publication for scientific articles that describe new findings in chemistry and interfacing areas of science, without any perceived evaluation of immediate impact.