The Royal Society of Chemistry最新文献

{"title":"Research progress on nanomaterial-empowered electrochemical biosensors for the detection of cardiac troponin I","authors":"Ning Zhang, Yuxin Zhu, Fachuang Li, Yusong Wang, Zheng Fu, Mengda Jia, Xiaoran Zhan and Wanqing Zhang","doi":"10.1039/D5RA04555J","DOIUrl":"https://doi.org/10.1039/D5RA04555J","url":null,"abstract":"<p >Acute myocardial infarction (AMI) is a prevalent and high-risk type of cardiovascular disease (CVD) and a major threat to global human health. Rapid and accurate diagnosis of CVD is important to protect life and health. Cardiac troponin (cTnI) is considered the best biomarker for diagnosing AMI because of its high specificity and sensitivity to acute cardiomyocyte injury. In recent years, electrochemical sensing technology has provided a unique platform for accurate quantitative detection of cardiac biomarkers, effectively shifting early diagnosis of CVD to a higher level of precision and intelligence. Among them, electrochemical biosensors have demonstrated significant potential in monitoring the occurrence and development of CVD due to their benefits including rapid response, high sensitivity, and low cost. This work focuses on the use of various sensing materials including carbon-based materials, metal matrix composites, ceramic matrix composites, MOF composites and conductive polymer nanomaterials in detecting cTnI by electrochemical biosensors. We also discuss the application of various electrochemical biosensors in biomarker detection under different techniques. Moreover, this review systematically reveals its mechanism of action and unique benefits. It focuses on systematically presenting the latest research progress in the detection of cardiac biomarkers based on electrochemical platforms. We deeply analyze their current application status and future development trends, geared towards providing a comprehensive and future reference for research.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 32","pages":" 26473-26489"},"PeriodicalIF":3.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra04555j?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyimide-driven innovations as \"inert\" components in high-performance lithium-ion batteries.","authors":"Yayue He, Zhenxi Li, Shilun Gao, Yinkui He, Yurong Liang, Yan Zhai, Yuxuan Li, Huabin Yang, Peng-Fei Cao","doi":"10.1039/d5mh00822k","DOIUrl":"https://doi.org/10.1039/d5mh00822k","url":null,"abstract":"<p><p>The rapid proliferation of lithium-ion batteries (LIBs) across portable electronics and electrified transportation systems has propelled unprecedented requirements for high energy density, prolonged cycle life, and improved safety protocols. Polyimides (PIs), attributed to the excellent thermal stability, mechanical robustness, chemical stability, and flame retardant properties, have been widely researched as \"inert\" materials to address critical challenges in advancing LIBs. Herein, this review provides design principles for employing PIs' inherent characteristics to develop next-generation high-performance LIBs with balanced energy density, rate capability, and operational reliability. PI-based \"inert\" components, including PI-based separators, solid-state electrolytes, protective layers, and binders, overcome the limitations of conventional materials by enhancing the safety of liquid batteries, reinforcing the mechanical properties, stabilizing the electrolyte/electrode interface, and maintaining the electrode integrity. Key challenges and optimization pathways for practical implementation are discussed and proposed. Finally, prospective research directions of PIs in LIBs are also outlined to provide critical orientation for research fields.</p>","PeriodicalId":87,"journal":{"name":"Materials Horizons","volume":" ","pages":""},"PeriodicalIF":12.2,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis planning for atomically precise metal nanoclusters.","authors":"Jingkuan Lyu, Jing Qian, Zhucheng Yang, Jianping Xie","doi":"10.1039/d5nh00353a","DOIUrl":"https://doi.org/10.1039/d5nh00353a","url":null,"abstract":"<p><p>The rational design and synthesis of materials with tailored properties remains a long-standing goal in advanced materials science. Metal nanoclusters (MNCs), distinguished by their atomic precision and molecule-like properties-including discrete energy levels, strong photoluminescence, and high property tunability-represent promising platforms for applications spanning catalysis to biomedicine. This perspective presents a comprehensive synthesis planning framework comprising three critical stages, <i>i.e.</i>, target design, route development, and condition optimization, systematically addressing MNC rational design and synthesis with special emphasis on thiolate-protected gold nanoclusters as exemplary systems. We first discuss design considerations for core and ligand shell engineering based on their profound influence on overall material properties. Subsequently, we examine methods and synthetic mechanisms for atomic-level tailoring of core and ligand shells to achieve target MNC synthesis. We then elucidate condition parameter tuning considerations based on their deterministic roles in reaction outcomes. While this structured approach provides a systematic methodology for MNC development, significant challenges persist owing to the high structural and synthetic complexity of MNCs. We then discuss the opportunities brought by recent advances in machine learning and high-throughput experimentation, which have demonstrated potential in addressing these challenges based on their superior computational and data analytical capabilities. We advocate for systematic adoption of this synthesis planning approach enhanced by data-driven methods, addressing inherent limitations in future development to better exploit these integrated approaches for accelerating rational MNC design and synthesis.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in the three-component synthesis of difluorinated compounds.","authors":"Zhan-Yong Wang, Ziyan Zhang, Weiyi Chen, Yang Liu, Aili Sun, Ran Xia","doi":"10.1039/d5ob01027f","DOIUrl":"https://doi.org/10.1039/d5ob01027f","url":null,"abstract":"<p><p>The three-component reaction offers a convenient method for synthesizing difluorinated compounds. In this review, we classify and discuss synthetic methodologies developed over the past decade (2014-2024) into three categories: (a) radical reactions, (b) difluorocarbene-mediated fluorination, and (c) other reaction types, including those using nucleophilic and electrophilic fluorine reagents. Various reagents such as AgF, pyridine·9HF, Selectfluor II, TMSCF₃, TMSCF₂Br, TMSCF₂PO(OEt)₂, RCF₃, (CFCO)₂O, ClCF₂H, ClCF₂CO₂Na, CF₂HSO₂Na, [Ph₃PCF₂H]Br, ClCF₂Cl, BrCF₂R, ICF₂COAr, and BrCF₂CO₂Et will be discussed.</p>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aminopeptidase N: a multifunctional and promising target in medicinal chemistry","authors":"Oldřich Farsa and Tomáš Uher","doi":"10.1039/D5RA03038B","DOIUrl":"https://doi.org/10.1039/D5RA03038B","url":null,"abstract":"<p >Aminopeptidase N (APN) is a zinc metalloproteinase present in almost all types of organisms and has various functions. Many of them are unrelated to its catalytic activity, which is why APN is sometimes classified as a moonlighting enzyme. APN is involved in carcinogenesis and angiogenesis. It also works as an entrance receptor for some coronaviruses and acts as a mediator during skin inflammation. Additionally, APN removes and helps to recycle regulatory proteins including neuropeptides, which is why its inhibitors hold therapeutic potential for a wide range of diseases, making the design and development of such molecules highly desirable. Some of them, such as bestatin or tosedostat, have already been tested as therapeutics with partial success. This article aims to bring an overview of multiple APN functions and implications for various diseases and their inhibitors which have already been prepared, and to suggest areas where the development of inhibitors may be promising in the future.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 32","pages":" 26455-26472"},"PeriodicalIF":3.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra03038b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One pot access to 2-iodo-2-deoxy nucleosides directly from glycals and unprotected nucleobases and their biological evaluation on the Japanese Encephalitis Virus†","authors":"Norein Sakander, Km. Archana, Ajaz Ahmed, Shriyanshi Mishra, Raj Kamal Tripathi and Debaraj Mukherjee","doi":"10.1039/D5RA02382C","DOIUrl":"https://doi.org/10.1039/D5RA02382C","url":null,"abstract":"<p >An expedient one-pot stereo- and regioselective synthesis of 2-iodo-nucleosides from protected glycals and nucleobases using easily available iodine and hexamethyldisilane as halogenating, and silylating agents respectively has been developed. Most of the products synthesized characterized as diastereomerically pure β-1,2-trans-diequitorial nucleosides hitherto not reported. The <em>in vitro</em> studies unveil the cogent antiviral activity of these newly synthesized nucleoside derivatives against the Japanese Encephalitis Virus (flavivirus) in the Vero cell line.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 32","pages":" 26490-26496"},"PeriodicalIF":3.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra02382c?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Cell climbing stones\" - varying the surfaces of electrospun nanofibers with protrusions as secondary structures to manipulate neural cell behaviors.","authors":"Yawen Wang, Xiaopei Zhang, Lijie Yao, Yuying Yan, Yuanfei Wang, Tong Wu","doi":"10.1039/d5nh00295h","DOIUrl":"https://doi.org/10.1039/d5nh00295h","url":null,"abstract":"<p><p>Effective neural repair requires the precise regulation of neurite outgrowth and coordinated migration of neural stem cells (NSCs) and Schwann cells (SCs). The synergistic integration of topographical cues, chemical signals and electrical stimulation can significantly enhance this process, among which topographical modulation has emerged as a research focus due to its direct regulatory effects on cellular behavior. Micro/nanoscale topological features (nanogrooves and protrusions) can markedly promote neurite outgrowth and cell migration by matching the mechanical characteristics of growth cone filopodia (100-300 nm). Building upon our previous work, we designed a series of aligned nanofibers with SiO₂ protrusions of varying sizes and concentrations to mimic \"cell climbing stones,\" systematically investigating their regulatory effects on neurite growth, and the migration of NSCs and SCs. The results demonstrated that nanofibers with oriented protrusions as secondary structures significantly enhanced the motility of SCs and NSCs while promoting neurite extension. Notably, nanofibers fabricated with 200 nm SiO₂ nanoparticles blended with PCL at 6% SiO₂ concentration exhibited the most pronounced regulatory effects on neural cell behavior.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design considerations for photoinitiator selection in cell-laden gelatin methacryloyl hydrogels.","authors":"Elvan Dogan, Ann Austin, Ayda Pourmostafa, Swaprakash Yogeshwaran, Hossein Goodarzi Hosseinabadi, Amir K Miri","doi":"10.1039/d5bm00550g","DOIUrl":"https://doi.org/10.1039/d5bm00550g","url":null,"abstract":"<p><p>Light-assisted bioprinting of protein-derived hydrogels has been widely used for tissue engineering and regenerative medicine. The practical challenges of the photoinitiators (PIs) are often overlooked in using photo-crosslinkable bioinks for <i>in situ</i> and <i>in vitro</i> applications. A higher concentration of PI is believed to increase the network density of a hydrogel thus reducing its mass transfer capacity, but PI can form reactive oxygen species (ROS) and cause unwanted side reactions around biological compartments. This study systematically investigates the role of ROS generation on mesenchymal stem cells encapsulated in gelatin-methacryloyl hydrogels when using type I PIs-<i>e.g.</i> lithium phenyl(2,4,6-trimethyl-benzoyl)phosphinate and 2-hydroxy-1-(4-hydroxyethyl-phenyl)-2-methyl-1-propanone, and type II PI-<i>e.g.</i> Eosin Y. The results reveal that higher concentrations of type I PIs provide a higher elastic modulus at the expense of enhanced ROS generation and a proportional decrease in viability. We report a novel hydrogel system with minimal PI loading where a reduction in elastic modulus is accompanied by a simultaneous decrease in pore size and ROS level leading to a significant increase in stem cell viability over one week of <i>in vitro</i> culture. In contrast, the type II PI reveals a moderate fluctuation of elastic modulus over a range of PI concentration correlated to fluctuations in ROS generation. Monitoring ROS level variations enables evaluation of each PI's impact on cell response, providing a strategy for the biofabrication of cell-laden constructs. This framework can inform the rational design of photo-crosslinkable hydrogels for light-assisted bioprinting and <i>in situ</i> crosslinking applications in regenerative medicine.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron oxide nano-adsorbent doped with nickel and palladium for phosphorus removal from water†","authors":"Pamela Sepúlveda, Jonathan Suazo-Hernández, Lizethly Cáceres-Jensen, María de la Luz Mora, Juliano Denardin, Alejandra García-García, Pablo Cornejo and Binoy Sarkar","doi":"10.1039/D5RA02256H","DOIUrl":"https://doi.org/10.1039/D5RA02256H","url":null,"abstract":"<p >Excessive phosphorus (P) in surface and ground water can cause serious environmental issues. This study aims to synthesize and characterize novel iron oxides (Fe<small>_<em>x</em></small>O<small>_<em>y</em></small>) nanoparticles (NPs) with and without Ni and Ni–Pd doping and unravel the NPs' performance and mechanism for P removal from water. X-ray diffraction, energy dispersive X-ray spectroscopy and X-ray photoelectron spectroscopy results confirmed successful doping of Ni and Ni–Pd on Fe<small>_<em>x</em></small>O<small>_<em>y</em></small> NPs. Fe<small>_<em>x</em></small>O<small>_<em>y</em></small>–Ni NPs exhibited a higher specific surface area and isoelectric point than Fe<small>_<em>x</em></small>O<small>_<em>y</em></small> and Fe<small>_<em>x</em></small>O<small>_<em>y</em></small>–Ni–Pd NPs. The kinetic data for P adsorption on Fe<small>_<em>x</em></small>O<small>_<em>y</em></small> NPs fitted to the pseudo-first order model and Fe<small>_<em>x</em></small>O<small>_<em>y</em></small>–Ni and Fe<small>_<em>x</em></small>O<small>_<em>y</em></small>–Ni–Pd NPs fitted to the pseudo-second order model. Adsorption isotherm data for Fe<small>_<em>x</em></small>O<small>_<em>y</em></small> NPs fitted to the Freundlich model and Fe<small>_<em>x</em></small>O<small>_<em>y</em></small>–Ni and Fe<small>_<em>x</em></small>O<small>_<em>y</em></small>–Ni–Pd NPs fitted to the Langmuir model. The maximum P adsorption capacity was the highest for Fe<small>_<em>x</em></small>O<small>_<em>y</em></small>–Ni (35.66 mg g<small>⁻¹</small>) followed by Fe<small>_<em>x</em></small>O<small>_<em>y</em></small>–Ni–Pd (30.73 mg g<small>⁻¹</small>) and Fe<small>_<em>x</em></small>O<small>_<em>y</em></small> NPs (21.97 mg g<small>⁻¹</small>), which was opposite to the P desorption order of these adsorbents. The adsorption and characterization analysis suggested that inner-sphere complexes and co-precipitation were the key mechanisms for P adsorption on Fe<small>_<em>x</em></small>O<small>_<em>y</em></small>–Ni and Fe<small>_<em>x</em></small>O<small>_<em>y</em></small>–Ni–Pd NPs. Therefore, Fe<small>_<em>x</em></small>O<small>_<em>y</em></small>–Ni NPs were a highly effective adsorbent for removing P from water.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 32","pages":" 26321-26337"},"PeriodicalIF":3.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra02256h?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective heterofunctionalization of kynurenic acid derivatives†","authors":"Levente Törteli, Péter Simon, Róbert Berkecz and István Szatmári","doi":"10.1039/D5RA04301H","DOIUrl":"https://doi.org/10.1039/D5RA04301H","url":null,"abstract":"<p >The latest findings in the literature show that kynurenic acid and its analogues are potent drug candidates against numerous neurological diseases. In this article, kynurenic acid derivatives were treated with NaOCl and NaOBr solutions and yielded the corresponding 3-halogeno compounds. The reaction is fast and conducted under mild conditions, and the yields are efficient just like the previous methods available for the same transformation. These newly synthesized halogeno compounds can serve as starting materials for the synthesis of 3-aminokynurenic acid analogues by treating the 3-bromokynurenic acid analogue with NaN<small>₃</small>. The solvent effect of this reaction was also examined. These reactions are suitable for the synthesis of 3-heterosubstituted kynurenic acid analogues.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 32","pages":" 26420-26427"},"PeriodicalIF":3.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra04301h?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}