The Royal Society of Chemistry最新文献

{"title":"Multifunctional miRNA delivery systems provide synergistic neuroprotection against cerebral ischemia reperfusion injury.","authors":"Linlin Zhao, Meiyu Hu, Xiaohang Yin, Hao Yang, Liyun Zhu, Pingyuan Sun, Xiya Wang, Songwei Ai, Yonghui Zheng, Genjie Li, Tingting Yang, Xuerui Chen, Jingyu Zhang","doi":"10.1039/d5mh00875a","DOIUrl":"https://doi.org/10.1039/d5mh00875a","url":null,"abstract":"<p><p>Effectively alleviating cerebral ischemia-reperfusion (I/R) injury is challenging despite the medical advances. Prompt restoration of blood flow after ischemic stroke causes secondary damage to the brain tissues, triggers neuroinflammation and overproduces reactive oxygen species (ROS). MiRNA regulates the genes involved in neuron apoptosis and neuroinflammation, thus exhibiting potential in ameliorating cerebral I/R injury. However, as miRNA is vulnerable to degradation, its effective delivery faces obstacles in clinical applications. Inspired by the therapeutic potential of miR-210 inhibitors in ischemic stroke-induced neuroinflammation, we constructed a multifunctional nanosystem composed of ceria nanozymes and zeolitic imidazolate framework-90 (ZIF-90) nanoparticles to deliver miR-210 inhibitors to treat cerebral I/R injury. Attributed to the proton sponge effect of ZIF-90, this nanosystem allows for the lysosome escape of miR-210 inhibitors to protect their intracellular bioactivity, while the integration of ZIF-90 and ceria nanozymes utilizes multi-enzyme cascade activities to constrain lipid peroxidation and reduce oxidative damage in brain tissues of mice with middle cerebral artery occlusion (MCAO). After crossing the blood-brain barrier, miR-210 inhibitors target TET2 to suppress pro-inflammatory cytokines, finally inhibiting neuroinflammation. More than the uncertain stability and efficacy of direct TET2 protein administration, the delivery of miR-210 inhibitors by multifunctional nanosystems engendered neuroprotection, indicating their potential for protein replacement therapy against cerebral I/R injury.</p>","PeriodicalId":87,"journal":{"name":"Materials Horizons","volume":" ","pages":""},"PeriodicalIF":10.7,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A robust strategy for thermoformable cellulosic composite bioplastics <i>via</i> hydrogen bond substitution.","authors":"Xuyue Liu, Jingzhou He, Tong Zhou, Shiwei Li, Yi Guo, Ting Han, Zehong Wang, Lijie Dong","doi":"10.1039/d5mh01191d","DOIUrl":"https://doi.org/10.1039/d5mh01191d","url":null,"abstract":"<p><p>Cellulose represents a promising renewable resource for the development of sustainable alternatives to petroleum-derived plastics, owing to its exceptional biodegradability and renewability. However, the extensive hydrogen-bonding network and ordered crystalline structure of cellulose limit its solubility and thermo-processability, posing significant challenges for large-scale production of recyclable high-performance bioplastics. In this study, we propose a robust strategy for cellulosic composite bioplastic by controlling the disruption and reformation of hydrogen bonds in ethyl cellulose (EC) nanocomposites incorporating rheologically tunable graphene (Rt-G), which can dynamically dissociate hydrogen bonds within the EC matrix. The cellulosic composite bioplastic can be efficiently formed <i>via</i> mild thermal processing at 150 °C under 20 MPa for 1 hour, demonstrating good thermoplastic processability across multiple cycles of thermoplastic processing and recovery molding. In addition, the cellulose composite bioplastic demonstrate approximately fivefold enhancements in both toughness and thermal conductivity compared to those of pristine EC. And they can be repeatedly reprogrammed into diverse shapes under mild processing conditions through thermoplasticity induced by hydrogen-bond disruption and reformation. These findings provide a promising pathway for the development of high-performance cellulosic composite bioplastics, offering a viable alternative to conventional petroleum-derived plastics.</p>","PeriodicalId":87,"journal":{"name":"Materials Horizons","volume":" ","pages":""},"PeriodicalIF":10.7,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in radical addition/divergent cyclization of ynones.","authors":"Liji Gu, Ruoyang Xu, Weiwei Huan, Yan Zhang","doi":"10.1039/d5ob01044f","DOIUrl":"https://doi.org/10.1039/d5ob01044f","url":null,"abstract":"<p><p>Over the past decade, the design of new radical reactions has emerged as an increasingly powerful strategy for constructing complex molecular scaffolds, typically characterized by predictable yet divergent reaction outcomes, a wide range of radical precursors, and various modes of initiation. Notably, radical cascade addition reactions serve as an efficient and practical strategy for constructing cyclic compounds. The scope of intermolecular radical acceptors is usually limited to C-C double or triple bonds. Compared to alkenes, radical addition to alkynes presents greater challenges. The regioselectivity in the radical addition step to internal alkynes can be controlled by adjusting the electronic effects of the substrate. Ynones are classic radical acceptors in organic synthesis, and many types of bio-relevant cyclic compounds could be obtained by cascade radical cyclization reactions. This review summarizes recent research advances in radical addition/cyclization reactions of ynones. We organized the content of this review based on the structures of the products to provide readers with a clearer overview and deeper understanding, hoping that this work will stimulate future research in this field.</p>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare earth doping: a strategy to enhance the catalytic activity of ZnFe2O4 in activating peroxymonosulfate for acetaminophen degradation","authors":"Hangdao Qin, Lei Xiao, Junnan Hao, Yong Wang, Jiming Huang, Guo Yang and Bo Xing","doi":"10.1039/D5RA05044H","DOIUrl":"https://doi.org/10.1039/D5RA05044H","url":null,"abstract":"<p >In this paper, ZnFe<small>₂</small>O<small>₄</small> was doped by two rare earth metals (La and Pr), and the as-prepared ZnLa<small>_0.5</small>Fe<small>_1.5</small>O<small>₄</small> and ZnPr<small>_0.5</small>Fe<small>_1.5</small>O<small>₄</small> were applied to activate PMS for acetaminophen degradation. ZnLa<small>_0.5</small>Fe<small>_1.5</small>O<small>₄</small> with the largest oxygen vacancy (O<small>_V</small>) content showed the highest acetaminophen degradation efficacy. About 89.7% of acetaminophen was removed within 60 min in the ZnLa<small>_0.5</small>Fe<small>_1.5</small>O<small>₄</small>/PMS system. Free radical quenching experiments and EPR tests confirmed that SO<small>₄</small>˙<small>⁻</small>, ˙OH, O<small>₂</small>˙<small>⁻</small> and <small>¹</small>O<small>₂</small> were the dominant reactive oxygen species (ROS). The role of La/Pr doping was explored through a series of comparative studies. The results indicated that La doping enhanced the content of oxygen vacancies, accelerated the electron transfer in the system, and thus sharply improved the catalytic performance of ZnFe<small>₂</small>O<small>₄</small>. Furthermore, the reusability, universality and actual water environment adaptability of ZnLa<small>_0.5</small>Fe<small>_1.5</small>O<small>₄</small> were investigated.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 35","pages":" 28651-28658"},"PeriodicalIF":4.6,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra05044h?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144831990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Annulative endoperoxidation of tetronates.","authors":"Najmeh Rahimi, Saba Sehrish, Samuel K Akompong, Bayler G Barnes, Cory J Windorff, Marat R Talipov, Rodolfo Tello-Aburto","doi":"10.1039/d5ob00663e","DOIUrl":"https://doi.org/10.1039/d5ob00663e","url":null,"abstract":"<p><p>A novel, annulative endoperoxidation of tetronate derivatives bearing unsaturated side chains is presented. The reaction requires a simple setup and proceeds under mild conditions to generate tricyclic endoperoxides in modest diastereoselectivities and useful yields. A free-radical mechanism is proposed.</p>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Light-mediated CO release from a tricarbonyl manganese(i) complex with a bidentate quinoxaline ligand","authors":"Rabaa M. Khaled, Krzysztof Radacki, Gamal A. E. Mostafa, Essam A. Ali, Ola R. Shehab and Ahmed M. Mansour","doi":"10.1039/D5RA03678J","DOIUrl":"https://doi.org/10.1039/D5RA03678J","url":null,"abstract":"<p >Reaction between 2-(pyridin-2-yl)quinoxaline (L) and [MnBr(CO)<small>₅</small>] afforded a dark-stable <em>fac</em>-[MnBr(CO)<small>₃</small>L] that releases CO upon exposure to visible light (468–525 nm). Different structural elucidation methods, including X-ray crystallography, were used to thoroughly characterize the structure of the organometallic compound. Prior to recording the profiles of dark-stability and photolysis in various organic solvents, the complex's solvatochromism features were examined experimentally and through quantum chemical calculations. As solutions become less polar, the lowest energy transition in DMSO, which is observed at 487 nm, is red-shifted, which could be explained by negative solvatochromism. Illuminating the pre-incubated solutions of the complex in organic solvents at 525 nm, with or without calf-thymus DNA, hen white egg lysozyme, or histidine, yields a two-step process perhaps associated with the sequential release of 3 CO molecules. In comparison, the principal factor influencing the CO release kinetics of the complex is the medium and the percentage of DMSO for example, with minimal interference from the biomolecules.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 35","pages":" 28642-28650"},"PeriodicalIF":4.6,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra03678j?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144814195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Ultrasound-mediated paclitaxel-loaded EGFR nanoparticles for targeted therapy in breast cancer","authors":"Zhenbin Xu, Hongpeng Duan, Yuling Shi, Zixia Zhou, Zhuo Wei, Xuechen Qian, Jian Lu, Yuemingming Jiang, Feng Mao, Nianyu Xue and Shengmin Zhang","doi":"10.1039/D5RA90090E","DOIUrl":"https://doi.org/10.1039/D5RA90090E","url":null,"abstract":"<p >Correction for ‘Ultrasound-mediated paclitaxel-loaded EGFR nanoparticles for targeted therapy in breast cancer’ by Zhenbin Xu <em>et al.</em>, <em>RSC Adv.</em>, 2025, <strong>15</strong>, 23136–23145, https://doi.org/10.1039/D5RA01016K.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 34","pages":" 27923-27923"},"PeriodicalIF":4.6,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra90090e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144814224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-mode optical thermometry based on up- and down-conversion photoluminescence in LiCaLa(MoO4)3:Er3+/Yb3+ phosphors with high sensitivity","authors":"Ikhlas Kachou, Yosra Bahrouni, Kamel Saidi, Mohamed Dammak, Irene Mediavilla and Juan Jiménez","doi":"10.1039/D5RA05181A","DOIUrl":"https://doi.org/10.1039/D5RA05181A","url":null,"abstract":"<p >The integration of down-conversion (DC) and up-conversion (UC) photoluminescence mechanisms has attracted significant attention for applications in optical thermometry and solid-state lighting. Combining both emission processes within a single material enables dual-mode temperature sensing, offering enhanced flexibility and precision. In this study, we report a pioneering investigation of the dual-mode thermometric performance of LiCaLa(MoO<small>₄</small>)<small>₃</small> phosphors co-doped with Er<small>³⁺</small> (0.02) and Yb<small>³⁺</small> (0.15), synthesized <em>via</em> a solid-state reaction route. To the best of our knowledge, this is the first report demonstrating simultaneous DC and UC-based thermometric behavior in this host matrix. The structural and morphological features of the synthesized phosphors were characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM), while their optical properties were analyzed using photoluminescence (PL) spectroscopy. XRD patterns confirmed the formation of a pure monoclinic LiCaLa(MoO<small>₄</small>)<small>₃</small> phase. Under UV excitation at 325 nm, green DC emissions from Er<small>³⁺</small> ions were observed, whereas intense green UC luminescence was recorded under 980 nm near-infrared excitation. Co-doping with Yb<small>³⁺</small> significantly enhanced both DC and UC emission intensities. A dual-mode optical thermometry approach was implemented using non-thermally coupled levels (NTCL) of Er<small>³⁺</small>, enabling simultaneous temperature evaluation from both DC and UC emissions. At 300 K, the relative sensitivities (<em>S</em><small>_r</small>) reached 1.2% K<small>⁻¹</small> for DC and 2.1% K<small>⁻¹</small> for UC modes. At elevated temperatures (510 K), the maximum absolute sensitivities (<em>S</em><small>_a</small>) were 13.6 × 10<small>⁻³</small> K<small>⁻¹</small> (DC) and 25 × 10<small>⁻³</small> K<small>⁻¹</small> (UC), respectively. The system demonstrated good temperature resolution, with uncertainties (δ<em>T</em>) below 0.313 K, confirming its potential for precise and robust optical temperature sensing.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 35","pages":" 28428-28438"},"PeriodicalIF":4.6,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra05181a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144814230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colorimetric detection of chromium(VI) using copper-based porphyrin organic framework materials and 8-hydroxyquinoline <i>via</i> a 'signal inhibition-target activation' response mode.","authors":"Jianhua Luan, Xin Zhang, Wenjing Qian, Xinyu Zhang, Mengru Shu, Xiubo Zhao, Nan Wang","doi":"10.1039/d5ay00926j","DOIUrl":"https://doi.org/10.1039/d5ay00926j","url":null,"abstract":"<p><p>Chromium(VI) ions (Cr(VI)) are highly toxic heavy metal pollutants, and their rapid detection holds significant importance for environmental protection. In this study, a colorimetric detection platform was developed using a copper-based porphyrin metal-organic framework (CuTCPP) with peroxidase-like (POD) activity. 8-Hydroxyquinoline (8-HQ) was used to inhibit the color-forming reaction. Upon the addition of the target analyte, Cr(VI), the colorimetric response was restored, since Cr(VI) can preferentially form a chelate with 8-HQ. Results showed that the detection system exhibited a linear range from 50 nM to 10 μM (<i>R</i>² = 0.999) with a low detection limit (LOD) of 22.3 nM, demonstrating excellent selectivity even in the presence of multiple interfering ions. The proposed intelligent response mechanism provided a visual, rapid, and user-friendly solution for on-site monitoring of Cr(VI) contamination, showing promising application potential in environmental analysis.</p>","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of structural modifications in synthetic vectors of lipid adjuvants on mRNA vaccine delivery.","authors":"Shruthilaya Chilumula, Pallavi Hanchate, Srilakshmi V Patri, Srujan Marepally","doi":"10.1039/d5bm00839e","DOIUrl":"https://doi.org/10.1039/d5bm00839e","url":null,"abstract":"<p><p>Lipid adjuvants act as a fundamental element in mRNA vaccine technology by performing as diverse functional parts: augmenting immune responses, assisting genetic payload delivery to target cells, and optimizing antigen presentation. They offer various advantages, such as particle stabilization, targeted delivery, refined endosomal escape mechanisms, and self-adjuvant characteristics that amplify immune activation. The lipid adjuvant structure is crucial for both maximizing delivery accuracy and unlocking tunable immune responses, positioning lipid adjuvants as critical components of next-generation vaccines. Understanding the structural alterations of the lipid adjuvants is necessary for the rational design and synthesis of next-generation novel lipid adjuvants that elicit superior immune responses in mRNA vaccines. To magnify the potency and safety of lipid adjuvants, researchers are investigating the fundamental aspects of designing an innovative lipid that leverages biodegradable linkages. This strategy emphasizes the critical roles of numerous lipids, such as ionizable/cationic lipids, helper lipids, phospholipids, and PEGylated lipids, for enhancing the stability, targeting precision, and immunogenic efficacy of mRNA vaccine delivery. Moreover, it elucidates the structural changes of recently developed cationic/ionizable lipid adjuvants, highlighting how their structure impacts vaccine efficacy, especially linkers. By leveraging these advancements, researchers are exploring the potential for highly effective and targeted mRNA vaccine platforms, paving the way for next-generation immunization strategies.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}