The Royal Society of Chemistry最新文献

{"title":"Urine volatile organic compounds in predicting chronic obstructive pulmonary disease risk in a national observational study.","authors":"Shuojia Xie, Junfeng Huang, Gengjia Chen, Huiting Luo, Yuexi Chen, Xiaowen Zhong, Linhang Yang, Ziwen Zheng, Zhaowei Yang, Shiyue Li, Linwei Tian, Ruchong Chen","doi":"10.1039/d5em00181a","DOIUrl":"https://doi.org/10.1039/d5em00181a","url":null,"abstract":"<p><p><i>Background</i>: chronic obstructive pulmonary disease (COPD) is a common respiratory disease caused by genetic and environmental factors, but the contribution of urine volatile organic compounds (VOCs) to the risk of COPD remains unclear. This study aims to use the NHANES data to explore the potential value of urine VOCs in predicting COPD. <i>Methods</i>: an epidemiological study including 782 participants from the National Health and Nutrition Examination Survey (NHANES) 2013-2018 was performed to evaluate the association between urine VOCs and COPD. Receiver operating characteristic (ROC) and the area under the ROC curve (AUC) analysis were used to evaluate the diagnostic performance of urine VOCs on COPD. <i>Results</i>: seven urine VOCs were associated with an increased risk of COPD [odds ratio (OR>1; <i>p</i> < 0.05)]. The dose-response relationship was also statistically significant between them. Meanwhile, urine VOCs can lead to the occurrence of COPD through the inflammatory effects. The area under the ROC curves for the combined urine VOC models as a predictor for COPD was 0.90. <i>Conclusions</i>: association between urine VOCs and an increased risk of COPD was found in the NHANES data. Inflammatory factors play an important role in the association of urine VOCs and COPD. In addition, urine VOCs could be useful in predicting COPD risk. More studies are needed to elucidate the mechanisms and clinical application values underlying the association between urine VOCs and COPD.</p>","PeriodicalId":74,"journal":{"name":"Environmental Science: Processes & Impacts","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plant-based diet and risk of arthritis: a nationwide cohort study of the Chinese elderly population.","authors":"Haohao Zhang, Junhao Liang, Yaxin Han, Jiajing Tian, Yahui Tu, Rui Fan, Wenli Zhu, Zhaofeng Zhang, Haifeng Zhao","doi":"10.1039/d5fo02192h","DOIUrl":"https://doi.org/10.1039/d5fo02192h","url":null,"abstract":"<p><p><i>Background</i>. This study was aimed at investigating the association between a plant-based diet and the risk of arthritis and at identifying a strategy that achieves the ambitious goal of healthy aging. <i>Methods</i>. The nationwide cohort study included 10 059 adults aged 65 and older from the 2008-2018 waves of the Chinese longitudinal healthy longevity survey (CLHLS). Dietary intake was collected using a simplified food frequency questionnaire and used to calculate the plant-based diet index (PDI). Arthritis was defined as participants self-reporting suffering from arthritis. Time-dependent Cox regression model was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for the risk of arthritis. Interaction analysis was used to explore the interaction between PDI and exercise status. Stratified analyses were used to examine factors that may modify the association. <i>Results</i>. During a median follow-up period of 4.2 years, 1482 participants who were free of arthritis at baseline reported arthritis. The highest quality of plant-based diet was associated with a 16.0% decrease in the risk of suffering from arthritis (HR: 0.840, 95% CI: 0.757, 0.932). Interaction analysis showed that participants with a high PDI and exercise had a significantly lower risk of arthritis. Stratified analysis showed that the association between PDI and arthritis was significant among participants living in rural areas. <i>Conclusions</i>. Greater adherence to a plant-based diet may help delay the onset of arthritis symptoms. Promoting plant-based dietary patterns may be a strategy to reduce arthritis incidence and improve healthy life expectancy.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A transferrin-targeted nanoplatform for MRI-guided visualization and potent suppression of tumors and pulmonary metastatic lesions.","authors":"Liya Tian, Pengju Ma, Wenxiu Zhuang, Yinlong Xu, Lihua Pang, Kai Guo, Ke Ren, Xueli Xu, Xiao Sun, Shunzhen Zheng","doi":"10.1039/d5nh00325c","DOIUrl":"https://doi.org/10.1039/d5nh00325c","url":null,"abstract":"<p><p>While targeted theranostics for cancer remains a pivotal research frontier, conventional ligand conjugation strategies exhibit persistent limitations in off-target accumulation and suboptimal tumor specificity, ultimately failing to achieve reliable detection of early-stage lesions or metastatic nodules while demonstrating insufficient therapeutic payload delivery. In this study, the manganese sulfide (MnS) nanoplatform was synthesized using transferrin (Tf) with tumor-targeting properties as a carrier by a simple fabrication method. Notably, compared to clinically prevalent Gd-based contrast agents, Tf-MnS exhibited superior <i>T</i>₁-weighted magnetic resonance imaging (MRI) contrast performance, with the longitudinal relaxation (<i>r</i>₁) reaching 7.5253 mM^-1 s^-1, which was significantly higher than 3.2915 mM^-1 s^-1 of Gd-DTPA, and in the MRI of subcutaneous tumors and lung metastatic lesions in mice, the maximum relative signal-to-noise ratios reached 46.33% and 40.33%, respectively. Remarkably, upon reaching the acidic tumor microenvironment, Tf-MnS disintegrated to release Mn²⁺ ions and hydrogen sulfide (H₂S). The Mn²⁺ ions participated in Fenton-like reactions to produce cytotoxic hydroxyl radicals, while H₂S concurrently inhibited catalase enzyme activity, thereby alleviating the insufficiency of the hydrogen peroxide substrate and amplifying the therapeutic outcome. This synergistic mechanism endowed Tf-MnS with a self-enhanced anti-tumor effect, inhibiting both lung metastatic lesions and subcutaneous tumors in mice of the Tf-MnS group, with a tumor inhibition rate of 54.26%. Collectively, this work proposes an innovative strategy for integrating accurate diagnosis and self-augmented therapy of tumors and lung metastatic lesions into a unified nanoplatform, offering a promising methodology for precision oncology.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In situ growth of carbon nanotubes on MXenes for high-performance electromagnetic wave absorption†","authors":"Zhichao Mu, Lanzhi Wang, Benhui Fan, Zuojuan Du, Jianling Yue, Yu Liu and Xiaozhong Huang","doi":"10.1039/D5RA03991F","DOIUrl":"https://doi.org/10.1039/D5RA03991F","url":null,"abstract":"<p >Two-dimensional transition metal carbides and nitrides (MXenes), especially titanium carbide, are ideal materials for high-performance microwave absorbers. Nonetheless, their characteristics of being prone to stacking and agglomeration seriously affect their application. Moreover, their elevated electrical conductivity results in the reflection of electromagnetic waves (EMW) rather than their absorption. This study proposes a simple strategy to grow CNTs on the surface of MXenes by chemical vapor deposition (CVD) technology, and introduces a SiO<small>₂</small> intermediate layer to uniformly distribute CNTs on the substrate surface. Controlling the growth of CNTs by adjusting the reaction time to regulate the microstructure and electromagnetic parameters of the composite materials, the wave absorption performance under low filling amount was significantly improved. MXene@SiO<small>₂</small>–CNTs exhibit a minimum reflection loss of −48.38 dB at a thickness of 2.1 mm, with an effective absorption bandwidth extending to 5.47 GHz (from 12.53 GHz to 18 GHz). The radar cross-section values of MXene@SiO<small>₂</small>–15CNTs are all below −15 dBm<small>²</small>, significantly diminishing the likelihood of radar detection of the target.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 32","pages":" 26506-26514"},"PeriodicalIF":3.9,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra03991f?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of <i>Lacticaseibacillus rhamnosus</i> GG supplementation on gastrointestinal and respiratory outcomes: a systematic review and meta-analysis of randomized controlled trials.","authors":"Khemayanto Hidayat, Lili Zhang, Hong Wei, Weiguo Zhang, Liqiang Qin, Yangwenshan Ou, Nan Li","doi":"10.1039/d5fo01780g","DOIUrl":"https://doi.org/10.1039/d5fo01780g","url":null,"abstract":"<p><p><i>Lacticaseibacillus rhamnosus</i> GG (LGG) supplementation has demonstrated efficacy in reducing diarrhea duration in children. However, its preventive potential and broader therapeutic applications beyond pediatric diarrhea remain less well characterized. A systematic review and meta-analysis were performed to investigate the efficacy of LGG supplementation on the risks of composite (including infections and symptoms) gastrointestinal (GI) and respiratory outcomes, as well as the duration of relevant symptoms. The protocol was pre-registered in the PROSPERO database (CRD42024539944). The PubMed, Web of Science, and Cochrane databases were searched for relevant articles. A random-effects model was applied to generate pooled relative risks (RRs) or weighted mean difference (WMD) estimates with 95% confidence intervals (CIs). Sixty-nine trials were included. LGG supplementation reduced the risk of composite GI outcomes (RR 0.88, 95% CI 0.81, 0.96; <i>N</i> = 38), primarily through a reduction in diarrhea risk (RR 0.64, 95% CI 0.52, 0.77; <i>N</i> = 24) and, to a lesser extent, taste disturbances (RR 0.40, 95% CI 0.22, 0.72; <i>N</i> = 5). Other GI outcomes-including vomiting (<i>N</i> = 13), nausea (<i>N</i> = 9), abdominal pain (<i>N</i> = 12), bloating (<i>N</i> = 8), constipation (<i>N</i> = 8), stomach rumbling (<i>N</i> = 3), and loss of appetite (<i>N</i> = 5)-showed limited effect. Respiratory outcome risk was also lower (RR 0.86, 95% CI 0.78, 0.94; <i>N</i> = 23), largely attributable to reduced respiratory infection risk (RR 0.87, 95% CI 0.79, 0.97; <i>N</i> = 18), with limited effects on respiratory symptom risk (<i>N</i> = 7). LGG supplementation shortened GI symptom duration (WMD -0.62, 95% CI -0.81, -0.44 days; <i>N</i> = 33), largely attributable to reduced diarrhea duration (-0.83, 95% CI -1.06, -0.59 days; <i>N</i> = 29), with limited effects on vomiting duration (<i>N</i> = 6). LGG had limited effects on respiratory symptoms (<i>N</i> = 6). Moderate-to-high heterogeneity was observed for the aforementioned outcomes, except GI outcomes other than diarrhea and GI symptom risk. Prediction intervals supported consistent benefits for diarrhea outcomes but frequently crossed the null for others, indicating greater uncertainty. Effects on diarrhea outcomes and respiratory infection risk were more consistent in children; evidence in adults was limited. Certainty was rated moderate for diarrhea outcomes and mostly low for others. LGG supplementation reduces diarrhea risk and duration in children, supported by moderate-certainty evidence and consistent effects across trials. Other outcomes showed more variable results, reflecting limited or inconsistent evidence. These findings support LGG's role in pediatric diarrhea management and prevention while underscoring the need for high-quality trials to clarify broader clinical applications.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid, multiplex, one-pot CRISPR/Dx system for detecting cancer fusion genes.","authors":"Jiaqi Li, Cia-Hin Lau, Jianchao Wang, Weidong Wu, Zhihao Huang, Xiaoqing Chen, Jiahui Li, Yumei Huang, Tao Wang, Yulin Li, Zihan Zhao, Meijing Xu, Gang Chen, Sheng Tong, Haibao Zhu","doi":"10.1039/d5ay00783f","DOIUrl":"https://doi.org/10.1039/d5ay00783f","url":null,"abstract":"<p><p>Targeted therapies directed at fusion genes have proven remarkably effective against cancers. Therefore, the rapid and reliable identification of cancer fusion genes can guide subsequent therapeutic treatment and predict prognosis. By integrating the RT-RPA and CRISPR/Cas12a approaches, we developed a one-pot CRISPR/Dx system for the rapid and multiplex detection of cancer fusion genes. A tube with unique assemblies was created using 3D printing technology to realize this application. As proof of principle, we demonstrated the feasibility of the one-pot CRISPR/Dx system in detecting lung cancer by targeting <i>ROS1</i> fusions. The performance of the one-pot CRISPR/Dx detection system was comparable to a two-tube-based testing platform. When tested with synthetic RNA fusions, both approaches efficiently detected all 14 <i>ROS1</i> fusions with an LOD in the range of 5-10 copies per μL, without generating a background signal, even in the presence of a large excess of wild-type RNA. The total reaction time for both approaches was 30 minutes. Notably, the one-pot CRISPR/Dx detection system minimized the operation steps and aerosol contamination without compromising detection sensitivity and specificity. Furthermore, its diagnostic power was validated using clinical samples. Thus, we successfully developed a rapid, multiplex, one-pot CRISPR/Dx detection system for detecting 14 clinically relevant <i>ROS1</i> fusions with high sensitivity and specificity. It is also cost-effective and simple to operate, thereby realizing the ultimate goal of establishing CRISPR/Dx as the paragon of cancer diagnostics for home self-testing and point-of-care testing.</p>","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-metallic element modulation of Co₃O₄/NiFe-LDH hetero-junction electrocatalysts for efficient oxygen evolution reaction.","authors":"Dipeng Sun, Yongqi Xu, Lijie Zang, Fengshuo Yu, Dong Zhao, Xiao Lyu","doi":"10.1039/d5cc02638e","DOIUrl":"https://doi.org/10.1039/d5cc02638e","url":null,"abstract":"<p><p>The doping of non-metallic boron generates oxygen vacancies and alters electron redistribution at the heterostructure interface. In an alkaline environment, the prepared B-Co₃O₄@NiFe-LDH electrocatalyst displays a low OER overpotential of 115 mV at 10 mA cm^-2, demonstrating superior OER activity.</p>","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ergosterol from edible fungi: Enhancing fatty acid oxidation <i>via</i> CPT1A to protect against diabetic kidney disease.","authors":"Zhonghua Dong, Xiao Li, Xuan Wang, Jingya Xu, Wei Xu","doi":"10.1039/d5fo00371g","DOIUrl":"https://doi.org/10.1039/d5fo00371g","url":null,"abstract":"<p><p><i>Background</i>: Diabetic kidney disease (DKD), a common microvascular complication of diabetes mellitus, is recognized as a leading cause of end-stage renal disease. Ergosterol, a natural sterol abundant in edible fungi, has shown pharmacological effects that may benefit DKD treatment. However, its precise mechanisms of action remain elusive. This study aimed to evaluate the therapeutic efficacy of ergosterol in DKD and to delineate the underlying mechanisms. <i>Methods</i>: Transcriptome microarray sequencing data from DKD patients retrieved from the public GEO database, as well as data from mouse DKD models, were analyzed to identify differentially expressed genes. Db/db mouse, high-glucose-induced HK-2 cells and conditioned THP-1 cells were employed to evaluate the impact of ergosterol on renal function, lipid metabolism, and macrophage phenotypic transformation. <i>Results</i>: Transcriptional profiling of DKD kidneys revealed alterations in fatty acid metabolism, which were corroborated in db/db mice. Ergosterol significantly improved renal function, reduced lipid accumulation, and mitigated inflammation. CPT1A, a key modulator of fatty acid metabolism, was identified as a target. The inhibition of CPT1A in renal tubular epithelial cells led to impaired fatty acid oxidation and lipid accumulation. Excessive renal lipids further stimulated macrophages to transform into pro-inflammatory phenotypes, leading to renal inflammation infiltration and exacerbating kidney damage. Ergosterol upregulated CPT1A expression through transcriptional regulation of FOXA1, thereby reducing lipid accumulation and subsequent renal inflammation. <i>Conclusion</i>: Ergosterol enhances renal fatty acid oxidation <i>via</i> the FOXA1/CPT1A pathway, reducing renal lipid accumulation and inflammation, potentially delaying DKD progression. This study elucidates the therapeutic potential of ergosterol in DKD therapy and provides new insights into the treatment of this disease.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased protein intake in healthy males exposed to an appetite modulating, whey-derived peptide hydrolysate.","authors":"Erin Stella Sullivan, Harriët Schellekens, Brendan T Griffin, Samantha J Cushen, Ken Howick, John F Cryan, Darren Dahly, Nessa Noronha, Aoife M Ryan","doi":"10.1039/d4fo06083k","DOIUrl":"https://doi.org/10.1039/d4fo06083k","url":null,"abstract":"<p><p>The identification of food-grade bioactives with proven orexigenic effects would mark significant progress in the treatment of disease-related malnutrition. To investigate the effects of two milk-derived hydrolysates (UL-2-141 (whey hydrolysate) and MF1145 (casein hydrolysate)) on appetite and energy intake in healthy humans, a single-blind, placebo-controlled, 3-arm cross-over feeding trial was conducted in 22 fasted, cannulated healthy male volunteers. Participants received 26 mg kg^-1 of both hydrolysates and placebo and were observed from morning to afternoon with a set breakfast and <i>ad libitum</i> lunch. Mean total daily energy and protein intakes when treated with placebo were 2673 kcal (95% CI: 2247-3100 kcal) and 128 g (95% CI: 105-152 g), respectively. Energy intake for either treatment was not significantly different from that for placebo (<i>p</i> = 0.266 for UL-2-141 and <i>p</i> = 0.796 for MF1145). Protein intake significantly increased in the UL-2-141 arm compared with that in placebo (+23 g, <i>p</i> = 0.044), but it did not significantly increase in the MF1145 arm (+13 g, <i>p</i> = 0.189). Appetite, hunger and satiety responses on VAS for either treatment were not significantly different from those obtained for placebo. GLP-1 was significantly higher pre-lunch in the UL-2-141 arm than in placebo (+8 pmol L^-1, <i>p</i> = 0.01) and in the MF1145 arm (+7 pmol L^-1, <i>p</i> = 0.039). GH was significantly lower pre-lunch only in the UL-2-141 arm than in placebo (-133 pg mL^-1, <i>p</i> = 0.027). Protein intake was significantly increased in the UL-2-141 arm, demonstrating appetite modulation, potentially <i>via</i> indirect or delayed stimulation of the ghrelin receptor. Since healthy adults are often not in tune with their physiological hunger, repeating the study in subjects with established anorexia may be prudent.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Site-selective C(sp³)-H amination of (het)aryl acetic acid derivatives under copper(II) catalysis.","authors":"Arun Kumar Hajra, Prasanjit Ghosh, Chandreyee Roy, Mrinalkanti Kundu, Sajal Das","doi":"10.1039/d5ob00787a","DOIUrl":"https://doi.org/10.1039/d5ob00787a","url":null,"abstract":"<p><p>A ubiquitous copper(II) catalyzed cross-dehydrogenative (CDC) process of (Het)arylacetamide derivatives employing free cyclic/acyclic secondary amines with the aid of 8-aminoimidazo[1,2-<i>a</i> pyridine] (8-AIP) as a bidentate chelating auxiliary has been successfully developed. This methodology exhibits a broad substrate scope with good functional group compatibility in the presence of air. Furthermore, the synthetic adaptability of this novel protocol is showcased through the post-diversification of synthesized derivatives.</p>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}