The Royal Society of Chemistry最新文献

{"title":"Lattice-reinforced polyurethane foam with stable thermal and mechanical performance under repeated vacuum cycling.","authors":"Sooyeon Ji, Jaemin Lee, Beomjun Choi, Jeongwoo Lee, Youngseok Oh, Ki Jun Kim, Wonjoon Choi, Dahyun Daniel Lim","doi":"10.1039/d6mh01447j","DOIUrl":"10.1039/d6mh01447j","url":null,"abstract":"<p><p>Developing thermally and mechanically robust insulation capable of maintaining performance under repeated vacuum cycling remains a critical challenge for aircraft, aerospace and cryogenic systems, where both thermal efficiency and structural integrity are required. This study focuses on overcoming the trade-off between low thermal conductivity and mechanical stability in polymer-based insulating materials that are prone to structural degradation under pressure fluctuations. Herein, we present a Kelvin lattice-reinforced foam that preserves intrinsic insulation properties of closed-cell polyurethane (PU). The lattice framework suppresses structural collapse during vacuum cycling, while the PU foam region preserves low thermal conductivity. As a result, the hybrid structure exhibits a peak stress enhancement of up to 25 times compared to pristine PU foam. Furthermore, after 50 vacuum cycles, the hybrid structure retains thermal conductivity to within 10%, and peak-to-plateau ratio by less than 20% from their initial values, demonstrating excellent retention of both thermal and mechanical properties. These results establish the PU-Kelvin hybrid as a viable insulation architecture for environments subject to repeated pressure fluctuations, including aircraft cabins, aerospace structures, and cryogenic applications.</p>","PeriodicalId":87,"journal":{"name":"Materials Horizons","volume":" ","pages":"10113-10123"},"PeriodicalIF":11.4,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148862710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whole egg consumption effects on vitamin D and carotenoids bioavailability in pre- and post-menopausal females: a randomized crossover controlled feeding trial.","authors":"Jung Eun Kim, Weili Hu, Lauren E O'Connor, Steven A Hulsey, Amber Jannasch, Bruce R Cooper, Luz Maria Comboni, Mario Ferruzzi, Wayne W Campbell","doi":"10.1039/d6fo02769e","DOIUrl":"10.1039/d6fo02769e","url":null,"abstract":"<p><p><i>Background & aims</i>: Whole egg (WE) is a good source of vitamin D and carotenoids but their effects on concurrent bioavailability from a co-consumed meal and differences by menopausal status, remain unclear. The aim of this study was to assess the effects of co-consuming WE with vitamin D and carotenoids-rich foods on their absorption in pre- and post-menopausal females. <i>Methods</i>: Nine pre-menopausal and 8 post-menopausal females completed 8 day trials (7 day controlled diet plus test day) separated by a 3-week washout. Participants consumed a cooked vegetable meal (primary source of vitamin D and carotenoids) with no egg (control) or 100 g of cooked WE (CWE). The meal provided 27 mg of carotenoids and 600 IU of vitamin D (mainly vitamin D₂ from fortified mushrooms) and eggs provided ∼0.5 mg of carotenoids and 80 IU of vitamin D₃. Blood was collected hourly for 10 hours and triacylglycerol-rich lipoprotein fractions (TRL) were isolated. Vitamin D metabolites and carotenoids in TRL were analyzed and the composite areas under the curve (AUC) were calculated. <i>Results</i>: Carotenoids AUC_{0-10 h} in TRL was significantly higher for the CWE than control in both pre-menopausal (104.2 ± 12.4 <i>vs.</i> 29.2 ± 12.4 ng mL^-1 × 10 h; <i>p</i> < 0.001) and post-menopausal females (62.7 ± 12.4 <i>vs.</i> 10.1 ± 12.4 ng mL^-1 × 10 h; <i>p</i> = 0.003). 25-hydroxyvitamin D₃ AUC_{0-10 h} in TRL was also higher with CWE than for the control in the pre-menopausal (1.34 ± 0.55 <i>vs.</i> 0.53 ± 0.55 ng mL^-1 × 10 h; <i>p</i> = 0.182) and significantly higher in the post-menopausal (2.70 ± 0.59 <i>vs.</i> 1.03 ± 0.59 ng mL^-1 × 10 h; <i>p</i> = 0.015) females. Vitamin D₂/D₃ and 25-hydroxyvitamin D₂ were undetectable. Menopausal status did not affect these postprandial responses. <i>Conclusion</i>: Co-consuming WE with a cooked vegetable meal effectively increased the absorption of carotenoids across life stages but not for vitamin D₂ from a cooked vegetable meal. Trial registration: NCT02679794.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":"9095-9106"},"PeriodicalIF":6.3,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149072948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Walnut consumption improves mood and is associated with increased urinary excretion of 5-hydroxyindoleacetic acid and urolithins in a randomized crossover trial.","authors":"María Fernanda Zerón-Rugerio, Isabella Parilli-Moser, Arnau Gonzalez-Rodriguez, Mireia Urpi-Sarda, María Diez-Hernández, Aradeisy Ibarra-Picón, Blanca Barrau-Martinez, Francisco Jose Pérez-Cano, Trinitat Cambras, Maria Izquierdo-Pulido","doi":"10.1039/d6fo00807k","DOIUrl":"10.1039/d6fo00807k","url":null,"abstract":"<p><p><i>Background & aims</i>: Walnuts are nutrient-dense foods rich in bioactive compounds that may support mental health. However, evidence linking walnut consumption to mood regulation and to changes in urinary metabolites potentially associated with these effects in humans remains limited. This randomized crossover trial (RCT) aimed to evaluate the effects of an 8-week walnut (<i>Juglans regia</i>) intervention on mood states in young adults and to explore the potential mechanistic links through urinary serotonin metabolite (5-hydroxyindoleacetic acid, 5-HIAA), cortisol, and urolithins. <i>Methods</i>: In this 18-week open-label RCT, 31 healthy young adults (mean age 24.0 ± 4.2 years; 90.3% female) consumed 40 g per day of walnuts for 8 weeks (intervention) and followed a nut-free control period of equal length, separated by a 2-week washout. Mood states, perceived stress, well-being, and trait food cravings were assessed using validated questionnaires. Urinary concentrations of 5-HIAA and cortisol were quantified <i>via</i> ELISA and normalized to creatinine. Walnut-derived urolithins were determined in urine samples as biomarkers of intake by HPLC-QTOF-MS. Linear mixed-effects models were used to test differences in outcome variables between intervention and control conditions, and repeated-measures correlations were performed to assess within-individual associations between the outcome variables. <i>Results</i>: Compared to the control condition, the 8-week walnut intervention significantly reduced total mood disturbance scores (-4.85 points, <i>p</i> = 0.030). In addition, the walnut intervention significantly increased urinary 5-HIAA levels, with no changes in urinary cortisol. Increases in urinary 5-HIAA were significantly associated with reductions in fatigue (<i>r</i> = -0.392, <i>p</i> = 0.031) and total mood disturbance (<i>r</i> = -0.362, <i>p</i> = 0.049). Urinary levels of urolithins significantly increased during the intervention and were strongly correlated with concurrent changes in urinary 5-HIAA (<i>r</i> = 0.537 and <i>r</i> = 0.634, respectively). <i>Conclusions</i>: Daily walnut consumption improved total mood disturbance scores in young adults. These findings were accompanied by increased urinary 5-HIAA and urolithin levels. The concurrent changes in these urinary metabolites may reflect dietary, microbial, or peripheral metabolic responses to walnut consumption; however, mechanistic pathways warrant further investigation. These findings highlight the relevance of whole-food strategies in nutritional approaches to mental health.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":"9107-9119"},"PeriodicalIF":6.3,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149072952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermally enhanced resistive switching in interface-engineered AgHfO_3-<i>x</i>/Al₂O₃ memristors <i>via</i> trap depopulation for neuromorphic computing.","authors":"Swaraj Mukherjee, Mubashir M Ganaie, Ayan Chatterjee, Chaitanya B Auti, Jonathan Adamu, Chittaranjan Das, Pradeep Kumar, Lavi Tyagi, Michael Saliba, Mahesh Kumar","doi":"10.1039/d6mh00879h","DOIUrl":"10.1039/d6mh00879h","url":null,"abstract":"<p><p>Thermal instability remains a fundamental bottleneck in oxide-based resistive random-access memory (RRAM), where elevated operating temperatures invariably increase the high-resistance-state (HRS) leakage current and collapse the ON/OFF switching window, severely limiting reliable deployment. Here, an Au/AgHfO_3-<i>x</i>/Al₂O₃/FTO (fluorine-doped tin oxide) memristor is reported in which this paradigm is inverted. The HRS current anomalously decreases with increasing temperature, yielding a reversible ∼25-fold enhancement in the ON/OFF ratio from 300 K to 400 K. This counter-intuitive behavior originates from trap-controlled space charge-limited conduction (SCLC) at the chemically sharp 5 nm Al₂O₃ interlayer, where thermal energy depopulates shallow trap states, suppressing hopping-assisted leakage without disrupting filamentary conduction in the low-resistance state. The optimized heterostructure achieves a room-temperature ON/OFF ratio of 349 ± 53, endurance exceeding 10³ bipolar switching cycles, retention over 25 000 s, and ten discrete analog conductance states spanning six orders of magnitude. Device-derived conductance states are directly used as synaptic weights in software-level simulations of handwritten-digit classification and image denoising on the MNIST benchmark. The handwritten-digit classification achieves 97.74% accuracy <i>via</i> transfer learning without implementation in a physical crossbar array or its associated peripheral circuitry. These results establish interface-engineered trap control as a design principle for thermally self-correcting memristors, a class where elevated temperature enhances rather than degrades performance, with direct relevance to neuromorphic hardware in thermally demanding environments.</p>","PeriodicalId":87,"journal":{"name":"Materials Horizons","volume":" ","pages":"10382-10395"},"PeriodicalIF":11.4,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, synthesis, and anticancer evaluation of Biginelli-derived DHPM-amide hybrids bearing clinically inspired kinase-directed pharmacophores: EGFR docking and DFT studies.","authors":"Sagar P Kothadiya, Jay B Maheta, Darshna K Lakhnotra, Yogesh O Bhola, Sureshkumar B Koradiya","doi":"10.1039/d6ra08838d","DOIUrl":"https://doi.org/10.1039/d6ra08838d","url":null,"abstract":"<p><p>A series of twelve novel dihydropyrimidine (DHPM)-amide hybrid conjugates (6a-c, 8a-c, 10a-c, and 12a-c) were rationally designed, synthesized, and biologically evaluated as potential EGFR-targeted anticancer agents against A549 non-small cell lung carcinoma (NSCLC) cells. The target compounds were constructed <i>via</i> a convergent two-step protocol: Biginelli multicomponent condensation to assemble the DHPM-carboxylic acid core (4a-c), followed by EDC·HCl/HOBt-mediated chemoselective amide coupling with four clinically inspired amine fragments derived from erlotinib/gefitinib (series 10), cabozantinib (series 8), imatinib (series 12), and a sorafenib bioisostere (series 6). All compounds were characterized by IR, ¹H NMR, ¹³C NMR, and low-resolution ESI-MS. MTT cytotoxicity screening identified compound 10b as the most potent analogue (IC₅₀ = 16.11 ± 0.11 µg mL^-1, equivalent to 23.31 µM), exceeding the molar potency of the reference methotrexate (IC₅₀ = 15.00 ± 0.48 µg mL^-1, equivalent to 33.01 µM). It should be noted that methotrexate is a dihydrofolate reductase inhibitor included solely as a general cytotoxicity control and is not a mechanistically matched EGFR comparator; the comparison therefore reflects relative cytotoxic potency only and does not imply EGFR selectivity. Molecular docking against EGFR (PDB 1M17), an erlotinib-bound inactive-conformation structure, returned the most favourable score for 10b (score = -7.819 kcal mol^-1), with predicted hydrogen bonds to ASP831 and LYS721, a halogen contact at ILE765, and an extensive 15-residue hydrophobic network; these poses indicate compatibility with the erlotinib-binding pocket rather than a confirmed ATP-competitive binding mode. DFT calculations at B3LYP/6-311G(d,p) characterised the electronic structure of the isolated molecule (Δ<i>E</i> = 4.045 eV; <i>ω</i> = 3.155 eV) and are reported as a physicochemical description only, without implying a causal link to cellular activity. Normal mode analysis indicated conformational stability of the 10b-EGFR complex, collectively identifying 10b as a promising lead for further optimisation and mechanistic evaluation, for which direct EGFR kinase assays remain necessary.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A dual-mode γ-CD/Fe,N-CD nanozyme enabled by host-guest interactions for the dual-mode fluorometric and colorimetric monitoring of zearalenone in wheat flour.","authors":"Ashraf M Mahmoud, Ali O Alqarni, Rayed Ali A Alqahtani, Jong Pil Park, Mohamed M El-Wekil, Ramadan Ali, Al-Montaser Bellah H Ali","doi":"10.1039/d6ra07703j","DOIUrl":"https://doi.org/10.1039/d6ra07703j","url":null,"abstract":"<p><p>Zearalenone (ZEN), a potent endocrine-disrupting mycotoxin produced by Fusarium fungi, frequently contaminates cereal-based foods worldwide, necessitating reliable analytical methods for food safety and regulatory compliance. Herein, we report an innovative dual-readout sensing strategy for both fluorometric and colorimetric quantification of ZEN, based on a unified catalytic nanoplatform of iron and nitrogen co-doped carbon dots decorated with γ-cyclodextrin (γ-CD/Fe, N-CDs). The enlarged macrocyclic cavity of γ-CD selectively accommodates the bulky 14-membered resorcylic acid lactone ring of ZEN <i>via</i> host-guest binding, simultaneously triggering two distinct signaling pathways: static quenching of the intrinsic carbon dot fluorescence through ground-state complex formation, and inhibition of TMB oxidation as the captured ZEN scavenges hydroxyl radicals generated by the proximal iron catalytic centers, reducing colorimetric signal intensity in a dose-dependent manner. The fluorescence channel exhibited linearity over 0.5-80.0 ng mL^-1 with an LOD of 0.21 ng mL^-1, while the colorimetric channel was linear over 5.0-55.0 ng mL^-1 with an LOD of 1.6 ng mL^-1. Applied to commercial wheat flour samples, the method yielded recoveries of 95.8-102.4% with RSDs below 4%, showing no significant deviation from conventional reference techniques. This bifunctional nanodevice offers a robust, mutually corroborating dual-channel platform for high-throughput ZEN surveillance in grain commodities.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13679709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucomannan and resistant starch in obesity management: a systematic review of satiety, gut fermentation, and weight-related and metabolic outcomes.","authors":"Refani Alycia Kusuma, Irwan Budiono, Idelia Akmaliyyah Natasyaesa, Zahra Darin Fatina, Syifa Fauzia Putri, Nabiilah Sya'baniyah, Indriana Ari Susanti","doi":"10.1039/d6fo03061k","DOIUrl":"10.1039/d6fo03061k","url":null,"abstract":"<p><p>Obesity is a growing global health challenge associated with dysregulated appetite, impaired gut function, and metabolic disorders. Glucomannan and resistant starch are functional dietary fibers that may influence obesity-related pathways through distinct but interconnected mechanisms. This systematic review aimed to synthesize current evidence regarding their effects on satiety and appetite regulation, gut fermentation and microbiota-related pathways, and weight-related and metabolic outcomes. A systematic search of Scopus, PubMed/MEDLINE, ScienceDirect, and the Cochrane Library was conducted without publication-date restrictions, with the final search performed on 25 August 2026. Eligible randomized and crossover trials, non-randomized intervention studies, and animal studies investigating glucomannan, resistant starch, or relevant formulations were included when they reported predefined obesity-related outcomes. Twenty studies met the inclusion criteria, comprising six randomized or crossover trials, three non-randomized intervention studies, and eleven animal studies. Several studies reported improvements in satiety, hunger, food or energy intake, body weight, adiposity, or metabolic outcomes, although findings were heterogeneous across interventions, populations, and study designs. Glucomannan-containing interventions were generally associated with viscosity-related satiety effects, whereas resistant starch was more frequently associated with gut fermentation, microbiota modulation, and short-chain fatty acid production. Mechanistic and metabolic evidence was predominantly derived from animal studies, and several human studies reported null findings. Overall, the findings suggest potential complementarity between glucomannan and resistant starch at the mechanistic level, but direct evidence supporting synergistic effects of their combined use remains limited.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":"8941-8965"},"PeriodicalIF":6.3,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Water-soluble conjugated molecular materials toward biomedical translational applications.","authors":"Huanxiang Yuan, Zhiqiang Gao, Yuqing Dong, Hao Zhao","doi":"10.1039/d6mh00944a","DOIUrl":"10.1039/d6mh00944a","url":null,"abstract":"<p><p>Water-soluble conjugated molecular materials (WSCMs) have exhibited hierarchical light harvesting, energy transfer, photosensitization, and photoconversion capabilities, thus achieving remarkable breakthroughs in disease-related biosensing, biotheranostics, and biophotoconversion. In contrast to the basic investigations, rare efforts have been devoted to truly realizing their biomedical translational applications toward industrialization. This review concisely summarizes the state-of-the-art applications of WSCMs in clinical gene detection, disease theranostics, and green biosynthesis of high-value chemicals. Furthermore, challenges and development directions of WSCMs toward biomedical translations in precise diagnosis kits, <i>in vivo</i> theranostics, and large-scale photobiocatalysis are discussed, clearly mapping future industrialization trajectories for personalized medicine, veterinary drugs, and industrial bio-related fermentation.</p>","PeriodicalId":87,"journal":{"name":"Materials Horizons","volume":" ","pages":"10064-10081"},"PeriodicalIF":11.4,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148785648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomimetic hierarchical structure for high-performance implantable fiber sensors.","authors":"Hao Guo, Wang Li, Tao Huang, Songlin Zhang, Huisheng Peng, Xuemei Sun","doi":"10.1039/d6mh00883f","DOIUrl":"10.1039/d6mh00883f","url":null,"abstract":"<p><p>Implantable fiber sensors are emerging as viable platforms for continuous <i>in situ</i> monitoring of physiological signals, yet their clinical translation remains limited. The core challenge lies not only in balancing mechanical compliance, electrical reliability, analytical specificity, and long-term stability but also in maintaining these properties at the tissue-device interface throughout chronic implantation. Biomimetic hierarchical architectures, which are common in living systems, have provided a practical route by enabling structural and functional integration across multiple scales. In this review, we summarize recent progress in biomimetic design principles for improving the performance of implantable fiber sensors. We first discuss bioinspired hierarchically structured conductive fiber substrates that combine conductivity, flexibility, and resistance to cyclic deformation. We then focus on bioinspired interfaces, membranes, and surface coatings to improve sensitivity, regulate mass transport, and suppress biofouling. Finally, we address mechanically adaptive and self-stabilizing interphases and discuss biosafety, biocompatibility evaluation, and postprocessing compatibility for the clinical translation of these sensing systems. Overall, this review aims to provide actionable biomimetic design insights that can accelerate the development of next-generation implantable fiber sensors with improved long-term performance and clinical applicability.</p>","PeriodicalId":87,"journal":{"name":"Materials Horizons","volume":" ","pages":"9982-10000"},"PeriodicalIF":11.4,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148785599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinspired plant-derived extracellular vesicles enabling dual-targeting therapy for primary ovarian insufficiency.","authors":"Yaoqin Mu, Xinyi Zhang, Keyi Ye, Qiuyue Liao, Wei Yang, Jun Dai, Fan Xia, Kezhen Li","doi":"10.1039/d6mh01330a","DOIUrl":"10.1039/d6mh01330a","url":null,"abstract":"<p><p>Extracellular vesicles (EVs) have emerged as promising therapeutic agents for restoring ovarian function and fertility in chemotherapy-induced premature ovarian insufficiency (POI). However, their limited ovarian targeting capacity and inefficient mitochondrial delivery have substantially constrained their therapeutic efficacy. Here, we present a biomimetic, dual-targeted EV platform derived from <i>Lycium barbarum</i> (TPP-GCM-LBEVs) and demonstrate its therapeutic potential in a mouse POI model. Hybridization with granulosa cell membranes (GCMs) confers intrinsic ovarian-homing capability, whereas subsequent surface conjugation with triphenylphosphonium (TPP) promotes mitochondrial targeting following cellular uptake. TPP-GCM-LBEVs efficiently target granulosa cells and their mitochondria <i>in vitro</i> and <i>in vivo</i>, with cellular internalization mediated predominantly by caveolae- and lipid-raft-dependent endocytosis. Subsequently, TPP-GCM-LBEVs restore mitochondrial ultrastructure and bioenergetic function in granulosa cells, thereby re-establishing ovarian redox and metabolic homeostasis. This mitochondrial rescue enhances the paracrine metabolic support provided to oocytes, thereby improving oocyte quality and developmental competence. Consistent with these effects, treatment with TPP-GCM-LBEVs rescues follicular development, ovarian endocrine function, and natural fertility in POI mice. Collectively, this cross-species, dual-targeted, plant-derived EV strategy provides a translatable and effective therapeutic framework for POI, with broader implications for mitochondria-associated reproductive ageing.</p>","PeriodicalId":87,"journal":{"name":"Materials Horizons","volume":" ","pages":"10207-10221"},"PeriodicalIF":11.4,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}