The Royal Society of Chemistry最新文献

{"title":"A tris(3,5-dimethylpyrazolyl)borate-supported germanium(IV) Lewis acid.","authors":"Jerin Joseph, Archana P V, Alex P Andrews, Ganping Wang, Laurent Maron, Ajay Venugopal","doi":"10.1039/d6dt01955b","DOIUrl":"10.1039/d6dt01955b","url":null,"abstract":"<p><p>The synthesis of a germanium(IV) Lewis acid bearing tris(3,5-dimethylpyrazolyl)borate (Tp^Me2) and its ability to promote phosphine oxide reduction is presented. A reaction between GeCl₄ and KTp^Me2 resulted in Tp^Me2GeCl₃, which upon treatment with AgOSO₂CF₃ yielded Tp^Me2Ge(OSO₂CF₃)₃. Despite possessing similar Lewis acidity compared to the previously reported Sn(IV) analogue, Tp^Me2Ge(OSO₂CF₃)₃ exhibits higher efficiency in promoting the reduction of phosphine oxides to the corresponding phosphines using phenylsilane as the reductant.</p>","PeriodicalId":71,"journal":{"name":"Dalton Transactions","volume":" ","pages":"14334-14338"},"PeriodicalIF":3.3,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149163726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topochemical synthesis of ternary metal sulfides including new LaAgS₂.","authors":"Glen R Hebberd, Toby J Blundell, Leon Bowen, Stewart J Clark, Emma E McCabe","doi":"10.1039/d6dt02059c","DOIUrl":"10.1039/d6dt02059c","url":null,"abstract":"<p><p>Ternary sulfides are increasingly sought after for applications as battery materials, photovoltaics and photocatalysts as a result of their small band gaps and good electrical conductivities but their synthesis is often more challenging than that of oxides. We report here the low temperature synthesis of new sulfide LaAgS₂ by an anionic redox topochemical reaction, alongside the synthesis of LaCuS₂ by mechanochemical topochemical reaction. Our computational work indicates that reaction enthalpies to form LaAgS₂, with structure closely related to that of LaCuS₂, are relatively small, consistent with our synthetic work. Structural analysis suggests this is due to the larger size of the Ag⁺ ion compared with Cu⁺. Diffuse reflectance measurements indicate that both sulfides have band gaps ∼2.1(2) eV.</p>","PeriodicalId":71,"journal":{"name":"Dalton Transactions","volume":" ","pages":"14601-14613"},"PeriodicalIF":3.3,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13639657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149101041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concentration-driven faceting of MgO polyhedra boosts glucose isomerization in water.","authors":"Kaiyue Cheng, Lin Gan, Meiqi Zheng, Wenying Shi, Xianggui Kong, Mingfei Shao","doi":"10.1039/d6dt02360f","DOIUrl":"10.1039/d6dt02360f","url":null,"abstract":"<p><p>A sustainable synthesis of polyhedral MgO exposing [200] facets is developed by modulating the raw concentration without organic solvents. The optimized catalyst exhibited 90.8% fructose selectivity and a yield of 43.3% in aqueous glucose isomerization. This work highlights crystal facet engineering as a promising strategy for biomass conversion catalysis.</p>","PeriodicalId":71,"journal":{"name":"Dalton Transactions","volume":" ","pages":"14344-14348"},"PeriodicalIF":3.3,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149101030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The dual-directional chemical bridge: decoupling the interfacial roles of spacer cations in two-dimensional/three-dimensional (2D/3D) perovskites.","authors":"Guxing Jiang, Xiangying Xue, Fangju Tao, Tahir Imran, Qichang Wang, Mohammad Khaja Nazeeruddin, Xiao-Xin Gao","doi":"10.1039/d6cc05370j","DOIUrl":"https://doi.org/10.1039/d6cc05370j","url":null,"abstract":"<p><p>2D/3D perovskite heterointerfaces are widely used to improve the operational stability of perovskite solar cells, but their molecular role is often described mainly in terms of surface passivation. Bulky spacer cations coordinate under-coordinated surface sites, form hydrogen-bonding networks, and suppress ion migration. Simultaneously, poorly coupled organic tails may increase tunnelling distance and weaken charge extraction. This review discusses bulky cations as dual-directional chemical bridges rather than simple insulating barriers. The polar headgroup anchors the inorganic lattice through coordination, hydrogen bonding, and conformational restriction, whereas the exposed organic segment may tune interfacial energetics through dipolar effects, orbital overlap, and intermolecular π-π coupling. We compare the chemical mechanisms governing downward lattice stabilization and upward electronic communication, and highlight surface-sensitive tools required to probe molecular orientation, local potential shifts, and buried interfacial interactions. Together, these considerations support a design framework in which spacer-cation arrays are treated as organized interfacial ensembles. In such ensembles, geometric matching and multiple non-covalent interactions may help connect lattice stabilization with charge extraction, providing a chemical basis for mitigating the efficiency-stability trade-off.</p>","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-channel digital surface-enhanced Raman spectroscopy resolves GPC1⁺MUC4⁺ single-exosome heterogeneity released by PANC-1 and BxPC-3 pancreatic cancer cells.","authors":"Xin Wang, Zuoxi Zhang, Bin Zheng","doi":"10.1039/d6ay01831a","DOIUrl":"https://doi.org/10.1039/d6ay01831a","url":null,"abstract":"<p><p>Extracellular-vesicle populations average molecular signals across particles and can conceal rare, co-expressing phenotypes. We developed a dual-channel digital surface-enhanced Raman spectroscopy platform that partitions individual CD63-captured vesicles and identifies glypican-1 (GPC1) and mucin 4 (MUC4) with 4-mercaptobenzoic acid and 5,5'-dithiobis(2-nitrobenzoic acid) nanotags. The method was evaluated with eight independent batches from each of PANC-1, BxPC-3, HPDE and hTERT-HPNE cell models, seven blinded PANC-1/BxPC-3 mixtures, artificial-serum spikes and defined interferents. Across 49 256 single-vesicle events, beta-binomial modelling estimated GPC1⁺MUC4⁺ fractions of 13.8% for PANC-1 and 37.8% for BxPC-3. The adjusted between-model difference was 24.1 percentage points (batch-cluster bootstrap 95% confidence interval, 21.6-26.5; <i>P</i> = 5.47 × 10^-9). The response was linear against log₁₀ concentration from 1.0 × 10⁵ to 1.0 × 10⁹ particles per mL; the extrapolated detection-limit estimate was 1.0 × 10⁴ particles per mL, the overall precision was 6.49% coefficient of variation, and the mean artificial-serum recovery was 100.5%. Blinded mixture estimates tracked the nominal BxPC-3 fraction, while grouped nested cross-validation classified the four cell sources with 90.6% accuracy. Digital SERS agreed with nanoflow cytometry, giving a concordance correlation coefficient of 0.980 and a mean relative bias of 1.51%. These results show that marker co-occurrence, rather than bulk abundance alone, can distinguish pancreatic-cell vesicle phenotypes and provide a quantitative route for studying source-dependent vesicle heterogeneity.</p>","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blinking membrane patterns induced by protein binding/unbinding.","authors":"Hiroshi Noguchi","doi":"10.1039/d6sm00785f","DOIUrl":"https://doi.org/10.1039/d6sm00785f","url":null,"abstract":"<p><p>Nonequilibrium membrane pattern formation is studied using meshless membrane simulation. Bound proteins are considered to have two states that generate different membrane spontaneous curvatures. Protein binding and unbinding occur cyclically owing to chemical potential differences, as an off-lattice active Potts model. It is found that this cyclic binding/unbinding can induce blinking domains, with oscillating size: convex domains of the proteins with a higher spontaneous curvature grow, and subsequently, the proteins change to the other state with a lower spontaneous curvature, resulting in domain shrinkage. These processes repeat. In thermal equilibrium, hexagonal convex domains are formed by the competition between bending and surface tension energies, so that they are stably formed only under positive surface tension. However, blinking domains can form even in tensionless membranes.</p>","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Denitrogenative thiolation of benzotriazinones: facile access to <i>ortho</i>-thiolated benzamides.","authors":"Dasari Chaithanya, Radhakrishnan Sakthiganapathi, Jaladi Jhansi, Ramaraju Korivi, Baburaj Baskar, Subramaniyan Mannathan","doi":"10.1039/d6ob01325b","DOIUrl":"https://doi.org/10.1039/d6ob01325b","url":null,"abstract":"<p><p>A metal-free denitrogenative thiolation of 1,2,3-benzotriazin-4(3<i>H</i>)-ones with thiols for the synthesis of <i>ortho</i>-thiolated benzamides in the presence of DBU is described. The reaction accommodates a broad range of <i>N</i>-aryl-substituted 1,2,3-benzotriazin-4(3<i>H</i>)-ones, as well as aryl and alkyl thiols, affording the desired products in moderate to high yields. The reaction is believed to proceed <i>via</i> a benzenediazonium intermediate. The scalability of the developed protocol was also further demonstrated.</p>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary flavonoids target the gut-liver axis for the management of cholestatic liver injury.","authors":"Dongsong Bai, Shaoqiang Fan, Yu Mu, Dan Zheng, Xueshi Huang, Hang Ma, Liya Li","doi":"10.1039/d6fo03181a","DOIUrl":"10.1039/d6fo03181a","url":null,"abstract":"<p><p>Cholestatic liver injury (CLI) is a progressive liver disorder characterized by impaired bile acid (BA) synthesis, transport, and excretion. This dysfunction leads to the intrahepatic accumulation of toxic BAs, which in turn triggers hepatic oxidative stress, inflammation, and subsequent fibrogenesis. Through enterohepatic circulation, the gut and liver form an integrated gut-liver axis that regulates BA metabolism. Gut microbiota and nuclear receptor farnesoid X receptor (FXR) are tightly involved in modulating this axis and play a critical role in maintaining BA homeostasis. Disruption of the gut-liver axis under cholestatic conditions contributes to gut dysbiosis, BA imbalance, impaired intestinal barrier integrity, hepatic inflammation, and fibrotic progression. Flavonoids, a major class of polyphenols present in various foods, possess microbial-dependent biotransformation and gut enrichment characteristics. Through coordinated modulation of gut microbiota, BA metabolism, and host signaling pathways, flavonoids display promising protective effects against multiple pathological outcomes associated with CLI. This review summarizes the pathological mechanisms of CLI and the molecular interactions through which dietary flavonoids modulate the gut microbiota-BA-FXR axis. It further discusses the dietary exposure, bioavailability, and translational relevance of flavonoids by comparing human dietary intake and systemic exposure with preclinical doses, while evaluating safety considerations and available clinical trial evidence. These insights provide a framework for evaluating the nutritional relevance of flavonoids and their potential as functional food ingredients for the prevention and management of CLI.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":"8913-8940"},"PeriodicalIF":6.3,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148987182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Matrix matters: the importance of the food matrix in bioaccessibility and basolateral recovery of microalgal-sourced DHA.","authors":"Daniëlle Willemina Rianne Wessels, Laura Leduc, Shanna Bastiaan-Net, Paula Perez Pardo, Lonneke Janssen Duijghuijsen, Vincenzo Fogliano, Marie Hennebelle, Nicoletta Pellegrini, Tamara Hoppenbrouwers","doi":"10.1039/d6fo02980a","DOIUrl":"10.1039/d6fo02980a","url":null,"abstract":"<p><p>Omega-3 long-chain polyunsaturated fatty acids (LC-PUFAs), such as docosahexaenoic acid (DHA), are known for their positive health effects. To meet recommended intake levels, people commonly consume fish and microalgal oils as supplements, typically in the form of encapsulated triacylglycerols (TAGs). However, ingesting omega-3 LC-PUFAs dispersed in a food matrix may be beneficial, as this has been shown to improve digestion for other oil types. This study investigated the <i>in vitro</i> bioaccessibility and basolateral recovery of DHA in DHA-rich microalgae oil in various forms: bulk oil, encapsulated oil, powdered oil, and oil incorporated into a protein matrix. After adapting the INFOGEST protocol for lipid digestion, we assessed bioaccessibility after <i>in vitro</i> digestion using back titration and gas chromatography coupled to a flame ionization detector (GC-FID). We used a Caco-2 cell model, adapted to take into account the lipid adhesion to the plastic plate, to assess basolateral DHA recovery. Results showed that the digestion of encapsulated oil and bulk oil was similar (<i>n</i> = 3). Powdered oil showed higher bioaccessibility than bulk oil (47.0 ± 2.5% for powder and 9.5 ± 0.7% for bulk, <i>n</i> = 3). In the Caco-2 model, powdered oil showed higher basolateral recovery (4.8 ± 0.9%) than bulk oil (1.2 ± 0.2%), although the experimental model limits interpretation (<i>n</i> = 3). To evaluate matrix effects, we designed a vegan cheese-like matrix (VCM) using different proteins. DHA in the VCM was 38% more bioaccessible than in bulk oil (<i>n</i> = 3), and we observed no differences in basolateral recovery. Our findings highlight that food matrices play a critical role in DHA bioaccessibility and basolateral recovery, potentially indicating increased intestinal uptake. Rather than a one-size-fits-all approach, methodological choices, including digestion protocols, transport models, and quantification strategies, should be selected based on the specific research question.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":"9234-9248"},"PeriodicalIF":6.3,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149101228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Waxy hull-less barley intake enhances intestinal secretory IgA associated with dendritic cell activation in gut-associated lymphoid tissue.","authors":"Manabu Wakagi, Toshihiko Shoji, Toshiro Kobori, Masao Goto","doi":"10.1039/d6fo02718k","DOIUrl":"10.1039/d6fo02718k","url":null,"abstract":"<p><p>Waxy hull-less barley (WHB), which is rich in β-glucan, reportedly exhibits immunomodulatory properties, but the underlying mechanism remains unclear. In this study, we investigated the immunological effects and underlying mechanism of a WHB-containing diet using DO 11.10 mice, in which the T-cell antigen (Ag)-specificity is largely restricted to ovalbumin to minimize WHB-specific adaptive immune responses. Fecal secretory IgA (SIgA) levels were consistently higher in the WHB intake group throughout the feeding period. In the ileum, expression of the IgA transporter polymeric immunoglobulin receptor (pIgR) and the retinoic acid-generating enzyme Raldh2 was significantly upregulated. WHB intake increased the ratio of MHCII⁺ CD86⁺ conventional dendritic cells (cDC) in the gut-associated lymphoid tissue (GALT) and peripheral blood, whereas no changes were observed in the spleen. IgA⁺ cells increased in peripheral blood but decreased in the GALT, whereas IgM⁺ and α4β7⁺ B cells were elevated in the GALT but reduced in the spleen. Microbiota analysis revealed increased α-diversity and a shift toward higher abundances of species in the butyrate-producing genera <i>Oscillospira</i>, accompanied by lower abundances of <i>SMB53</i> and <i>Allobaculum</i>. Notably, the abundance of <i>Allobaculum</i> species was negatively correlated with fecal SIgA. These findings suggest that WHB consumption is associated with increased intestinal IgA secretion, activation of gut cDCs, upregulation of <i>Raldh2</i> and <i>pIgR</i>, and coordinated changes in B-cell dynamics and the gut microbiota.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":"9000-9012"},"PeriodicalIF":6.3,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}