醋酸铜介导的2-吡啶取代丙烯腈与DMSO的硫甲基化反应

IF 4.6 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

RSC Advances Pub Date : 2025-10-16 DOI:10.1039/D5RA07270K

Min Ye, Jie Yang, Cheng Huang and Zhengwang Chen

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引用次数: 0

摘要

以丙烯腈和二甲亚砜为原料，高效合成了多种烯基甲基硫醚。这种醋酸铜介导的硫甲基化反应提供了相应的产物，具有广泛的底物范围和中等至优异的收率。这种转变是通过乙烯基C-H键的直接功能化实现的，从而形成立体定向的内炔的正规氰基硫代化产物。

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Copper acetate mediated thiomethylation of 2-pyridine-substituted acrylonitriles with DMSO

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Copper acetate mediated thiomethylation of 2-pyridine-substituted acrylonitriles with DMSO

An efficient synthesis of a variety of alkenyl methyl thioethers from acrylonitriles and dimethyl sulfoxide is described. This copper acetate mediated thiomethylation reaction provides the corresponding products with broad substrate scope in moderate to excellent yields. This transformation is achieved through direct functionalization of vinylic C–H bonds, resulting in stereospecific formation of the formal cyanothiolation product of internal alkynes.

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来源期刊

RSC Advances chemical sciences-

CiteScore

7.50

自引率

2.60%

发文量

3116

审稿时长

1.6 months

期刊介绍： An international, peer-reviewed journal covering all of the chemical sciences, including multidisciplinary and emerging areas. RSC Advances is a gold open access journal allowing researchers free access to research articles, and offering an affordable open access publishing option for authors around the world.