The Royal Society of Chemistry最新文献

{"title":"Pd-catalyzed enantioselective reductive Heck reaction of mono-fluoro, <i>gem</i>-difluoro, and trifluoromethyl tethered-alkenes.","authors":"Naveen Sihag, Hemaang Bhartiya, Swati Jain, Jitendra Singh, S Rajagopala Reddy, M Ramu Yadav","doi":"10.1039/d5cc01559f","DOIUrl":"https://doi.org/10.1039/d5cc01559f","url":null,"abstract":"<p><p>Herein, we present an enantioselective, fluorine-retentive Pd-catalyzed reductive Heck cyclization reaction of fluorinated alkenes, enabling the synthesis of all-carbon quaternary 3,3-disubstituted fluoroalkyl-tethered oxindoles. Control experiments and DFT studies have provided insights into the reaction mechanism and stereochemical induction.</p>","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of functionalized lactones: catalytic cross-coupling of 1,2-diols and allylic alcohols.","authors":"Priyanka Maharana, Raman Vijaya Sankar, Muniyandi Sankaralingam, Chidambaram Gunanathan","doi":"10.1039/d5cc02207j","DOIUrl":"https://doi.org/10.1039/d5cc02207j","url":null,"abstract":"<p><p>Simple industrial feedstock chemicals such as allylic alcohols and 1,2-diols are cross-coupled to deliver δ-hydroxybutyrolactones. The reaction occurs through O-H bond activation <i>via</i> amine-amide metal-ligand cooperation involving allylic aldehydes, radical intermediates, and Ru(III) species, as established by EPR studies. This tandem process proceeds with the liberation of molecular hydrogen as the only green byproduct.</p>","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbamothioate-mediated Selectfluor™ oxidation for the synthesis of benzenesulfonyl fluorides in chalcone derivatives†","authors":"Boye Jiang, Juan Zhang, Boning Wang, Airui Zhou, Yan Zou, Qingguo Meng, Qingjie Zhao, Xiaoyun Chai and Conghao Gai","doi":"10.1039/D5RA03427B","DOIUrl":"https://doi.org/10.1039/D5RA03427B","url":null,"abstract":"<p >A carbamothioate-mediated method for synthesizing benzenesulfonyl fluorides <em>via</em> Selectfluor™ oxidation is reported, enabling compatibility with α,β-unsaturated chalcone derivatives without Michael addition side reactions. This approach offers moderate yields, broad functional group tolerance, and applications in covalent drug discovery, facilitating the incorporation of sulfonyl fluoride warheads into complex electrophilic scaffolds.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 27","pages":" 22018-22022"},"PeriodicalIF":3.9,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra03427b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144492513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outstanding Reviewers for <i>Analytical Methods</i> in 2024.","authors":"","doi":"10.1039/d5ay90071a","DOIUrl":"https://doi.org/10.1039/d5ay90071a","url":null,"abstract":"<p><p>We would like to take this opportunity to thank all of <i>Analytical Methods</i>' reviewers for helping to preserve quality and integrity in chemical science literature. We would also like to highlight the Outstanding Reviewers for <i>Analytical Methods</i> in 2024.</p>","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An AAQPR peptide from <i>Aspergillus oryzae</i>-fermented wheat peptone promotes the regenerative potential of dermal and epidermal layers of the skin in <i>in vitro</i> assays and clinical trials.","authors":"Sae Woong Oh, Eunbi Yu, Kitae Kwon, Hye Ja Lee, Hyun Sook Yeom, Kyung Man Hahm, Jin Oh Park, Jae Youl Cho, Jongsung Lee","doi":"10.1039/d5bm00571j","DOIUrl":"https://doi.org/10.1039/d5bm00571j","url":null,"abstract":"<p><p>Because of the activity and stability of existing traditional proteins, promoting the regenerative potential of skin defects caused by various environmental stresses is challenging. Small peptides with relatively high activity and stability show potential for skin tissue regeneration. We previously demonstrated that <i>Aspergillus oryzae</i>-fermented wheat peptone enhanced the proliferation and hydration of human epidermal keratinocytes. In this study, the AAQPR peptide (INCI ID: 37800, PEP5) was selected from <i>Aspergillus oryzae</i>-fermented wheat peptone, and its regenerative potential was examined in both human primary dermal fibroblasts and epidermal keratinocytes. Moreover, the translational properties of PEP5 have been investigated in humans. Cell proliferation, collagen production, oxidative stress, and pro-inflammatory cytokines in fibroblasts and keratinocytes are important factors that affect skin regeneration. We observed that PEP5 induced collagen production through the Smad2/3 signaling pathway in human dermal fibroblasts. Autodock analysis showed the possibility that PEP5 physically interacts with the transforming growth factor-β receptor, leading to collagen production. PEP5 attenuated ultraviolet A (UVA)-induced dysregulation of metalloproteinase activity, collagen integrity, and inflammatory signaling in human fibroblasts. A comparable protective effect was observed in the human epidermal keratinocyte cell line, HaCaT cells, where PEP5 suppressed UVA-induced oxidative stress and cytokine production. Furthermore, PEP5 upregulated the expression of hydration-related genes in HaCaT cells, leading to skin hydration. In clinical studies, PEP5 treatment resulted in increased skin hydration and a reduction in fine wrinkles compared to the placebo group. These data suggest that PEP5 could be introduced as a potential therapeutic agent to help improve external stress on the skin.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Constructing a hemostatic sponge loaded with copper nanoparticles and carboxymethyl chitosan for wound hemostasis and infection prevention.","authors":"Huiting Fu, Marziya Amantay, Jua Kim, Tao Jiang, Haobo Pan, Yingbo Wang","doi":"10.1039/d5bm00556f","DOIUrl":"https://doi.org/10.1039/d5bm00556f","url":null,"abstract":"<p><p>Uncontrolled hemorrhage and infection pose serious risks to patient survival, highlighting the critical need for multifunctional hemostatic materials that are safe, effective, and highly biocompatible. In response to this clinical demand, we have developed a novel design strategy that rapidly achieves hemostasis and prevents infection. This research introduces a dual-network multifunctional hemostatic sponge, CMC/PDA@Cu, crafted from polysaccharide materials and specifically engineered for application at bleeding sites compromised by drug-resistant bacteria. Utilizing the natural hemostatic properties of carboxymethyl cellulose (CMC), this material facilitates swift coagulation <i>via</i> electrostatic interactions that enhance the adhesion and aggregation of blood cells. Concurrently, copper nanoparticles (Cu-NPs) are synthesized <i>in situ</i> through redox reactions with copper ions and the catechol groups in polydopamine (PDA), enabling the prolonged release of copper ions and achieving 48 hours of antibacterial activity. The synergistic photothermal properties of PDA and Cu-NPs increased the photothermal conversion efficiency to 27.5%, significantly reducing the time required for bacterial elimination from 24 hours to just 3 hours. Furthermore, copper ions serve as cationic coagulation enhancers, bolstering hemostatic efficiency. The resultant material offers a combined solution for effective hemostasis and infection management. In experimental applications using a rat liver hemorrhage model, the CMC/PDA@Cu sponge dramatically minimized blood loss to 0.02 ± 0.01 mg, marking the fastest recorded hemostasis time of 37.17 ± 3.76 seconds. In a separate rat tail amputation model, the sponge reduced the blood loss to 0.91 ± 0.47 g, with a hemostasis time of 75.01 ± 4.52 seconds. These results lay a foundational mechanistic basis for the rational design of advanced, safe, and controllable hemostatic materials, elucidating the critical structure-function relationships in terms of material composition, surface characteristics, and their impact on hemostasis, antimicrobial efficacy, and biocompatibility. This work sets the stage for the future development of next-generation hemostatic materials aligning with clinical requirements.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DyeLeS: a web platform for predicting and classifying fluorescence properties of bioactive molecules†","authors":"Jiangcheng Xu, Wenbo Yu, Nan Zhou, Jiamin Zhong, Jintian Lyu, Zhihao Su, Yu Chen and Kui Du","doi":"10.1039/D5RA03164H","DOIUrl":"https://doi.org/10.1039/D5RA03164H","url":null,"abstract":"<p >Fluorescent drug molecules play a pivotal role in biomedical research and precision medicine. Their intrinsic fluorescence enables real-time tracking of drug distribution, target engagement, and metabolic pathways, while avoiding interference from external labeling. However, traditional fluorescent drug discovery relies heavily on trial-and-error approaches, which are inefficient and resource-intensive. To address this, we developed DyeLeS (Dye-Likeness Scoring), a web platform designed to rapidly evaluate molecular fluorescence potential and predict key photophysical properties such as Stokes shift and quantum yield. DyeLeS utilizes a curated dataset of fluorescent and non-fluorescent compounds, applies a Naive Bayes-inspired algorithm for fluorescence classification (AUC = 0.995), and employs a LightGBM model for quantitative prediction of fluorescence properties, achieving an <em>R</em><small>²</small> of 0.88 in absorption wavelength (<em>λ</em><small>_abs</small>) prediction. Leveraging DyeLeS, this study constructed FluoBioDB, the first publicly available library of fluorescent bioactive compounds, encompassing 32 865 structurally diverse molecules, including kinase inhibitors and GPCR modulators. Case analyses indicate that FluoBioDB compounds typically possess polycyclic conjugated frameworks, donor–acceptor (D–A) structures, and rigid planar cores, endowing them with strong potential for applications in bioimaging, targeted therapy, and theranostics. This work presents a robust computational framework and a valuable molecular resource to facilitate the rapid discovery and optimization of fluorescent drug candidates. All source codes and datasets are available at https://github.com/MolAstra/DyeLeS, and the web server can be accessed at https://dyeles.molastra.com.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 27","pages":" 21977-21986"},"PeriodicalIF":3.9,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra03164h?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144492453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carrageenan: structure, properties and applications with special emphasis on food science","authors":"Faiza Jabeen, Zil-e-Aimen, Rimsha Ahmad, Sadullah Mir, Nasser S. Awwad and Hala A. Ibrahium","doi":"10.1039/D5RA03296B","DOIUrl":"https://doi.org/10.1039/D5RA03296B","url":null,"abstract":"<p >This comprehensive study examines the versatile applications of carrageenan, a sulphated polysaccharide derived from red seaweeds, across environmental remediation, biomedical sciences, and food technology. The study also explains carrageenan's structural characteristics, physicochemical properties and the three primary types: kappa, iota, and lambda. In wastewater treatment, carrageenan-based materials demonstrate efficacy in removing heavy metals, dyes, and organic compounds through adsorption and flocculation mechanisms. The biomedical potential of carrageenan is explored, highlighting its role in drug delivery systems, tissue engineering, and wound healing applications. The review also addresses carrageenan's significance in the food industry as a thickening agent, stabilizer, and preservative. While acknowledging potential drawbacks, including gastrointestinal concerns and environmental impacts of seaweed harvesting, the study presents a balanced analysis of carrageenan's applications. This review underscores carrageenan's potential as a versatile, eco-friendly solution across multiple sectors, contributing to advancements in sustainable technologies and biomedical innovations.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 27","pages":" 22035-22062"},"PeriodicalIF":3.9,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra03296b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144492515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous and sensitive determination of hydroquinone, catechol, and resorcinol with a palladium nanoparticles/poly(bromocresol green) modified glassy carbon electrode.","authors":"Çağrı Ceylan Koçak","doi":"10.1039/d5ay00511f","DOIUrl":"https://doi.org/10.1039/d5ay00511f","url":null,"abstract":"<p><p>In this study, catechol (CC), hydroquinone (HQ), and resorcinol (RC) - dihydroxybenzene isomers - were determined simultaneously using the composite surface. The proposed material was prepared <i>via</i> electrochemical polymerization of Bromocresol Green (BCG) followed by electrodeposition of palladium nanoparticles (Pd). The developed electrode was characterized using X-ray Photoelectron Spectroscopy (XPS), Scanning Electron Microscopy (SEM), Electrochemical Impedance Spectroscopy (EIS), and X-ray Energy Dispersive Spectroscopy (EDX) techniques. Electrochemical measurements were performed using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) in pH 7 phosphate buffer solution. The Pd nanoparticle deposited polymerized BCG-modified glassy carbon electrode (Pd/Poly(BCG)/GCE) displayed enhanced current sensitivity for all three isomers compared to a bare GCE and Poly(BCG)/GCE. Thus, this was attributed to the synergistic effect of the improved active surface area of Poly(BCG) and the unique properties of Pd nanoparticles. Under optimized conditions, three well-separated oxidation peaks were achieved by DPV for HQ (19 mV), CC (130 mV), and RC (430 mV) at the Pd/Poly(BCG)/GCE during the simultaneous concentration change of the isomer mixture. The limit of detection values (S/N = 3) were found to be 89 nM, 74 nM, and 98 nM for HQ, CC, and RC, respectively. Thus, the high sensitivity, adequate reproducibility, good stability, and easy preparation of the Pd/Poly(BCG)/GCE surface made it a promising candidate for the determination of dihydroxybenzene isomers.</p>","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solvent-free mechanochemical access to phase-pure Cs-Co-Cl halometalates with tuneable electronic properties for energy applications.","authors":"Pablo Garrido, Darío Espinoza, Karem Gallardo, Rosa M González-Gil, Rodrigo Castillo","doi":"10.1039/d5dt01355k","DOIUrl":"https://doi.org/10.1039/d5dt01355k","url":null,"abstract":"<p><p>We report a solvent-free mechanochemical route for the selectively synthesis of three different caesium cobalt chlorides: CsCoCl₃, Cs₂CoCl₄, and Cs₃CoCl₅, by simply tuning the CsCl : CoCl₂ precursor ratio. This is the first comprehensive comparative study of these phases synthesized in pure form, enabling a clear correlation between composition, crystal structure, and optoelectronic properties. Each phase exhibits a unique Co²⁺ coordination geometry: octahedral in CsCoCl₃ and tetrahedral in Cs₂CoCl₄ and Cs₃CoCl₅, as revealed by XRD, SEM-EDS, Raman, and XPS, with several features reported here for the first time. All phases display high thermal stability and narrow optical bandgaps (1.65-1.70 eV), supported by ligand field analysis and CIE colorimetry. Valence and conduction band energies determined by VB-XPS and cyclic voltammetry reveal a systematic, composition-driven tuning of energy levels across the series. Importantly, the band edge alignment are suitable for visible-light-driven hydrogen evolution and photovoltaic applications. SCAPS-1D simulations predict power conversion efficiencies up to 17.1%, positioning these halocobaltates as promising absorbers. Altogether, this work introduces a scalable synthesis route and demonstrates the potential of cobalt-based halide frameworks as modular systems for solar energy conversion and photocatalysis.</p>","PeriodicalId":71,"journal":{"name":"Dalton Transactions","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}