The Royal Society of Chemistry最新文献

{"title":"Cell-scale dynamic modeling of membrane interactions with arbitrarily shaped particles.","authors":"Didarul Ahasan Redwan, Justin Reicher, Xin Yong","doi":"10.1039/d5sm00567a","DOIUrl":"https://doi.org/10.1039/d5sm00567a","url":null,"abstract":"<p><p>Modeling membrane interactions with arbitrarily shaped colloidal particles, such as environmental micro- and nanoplastics, at the cell scale remains particularly challenging, owing to the complexity of particle geometries and the need to resolve fully coupled translational and rotational dynamics. Here, we present a force-based computational framework capable of capturing dynamic interactions between deformable lipid vesicles and rigid particles of irregular shapes. Both vesicle and particle surfaces are represented using triangulated meshes, and Langevin dynamics resolves membrane deformation alongside rigid-body particle motion. Adhesive interactions between the particle and membrane surfaces are modeled using two numerical schemes: a vertex-to-vertex mapping and a vertex-to-surface projection. The latter yields more accurate wrapping energetics, as demonstrated by benchmark comparisons against ideal spheres. The dynamic simulations reveal that lower particle-to-vesicle mass ratios facilitate frequent particle reorientation and complete membrane wrapping, while higher mass ratios limit orientation changes and stabilize partial wrapping. To illustrate the framework's versatility, we simulate interactions involving cubical, rod-like, bowl-shaped, and tetrahedral particles with spherical, cigar-shaped, or biconcave vesicles. This generalizable modeling approach enables predictive, cell-scale studies of membrane-particle interactions across a wide range of geometries, with applications in environmental biophysics and nanomedicine.</p>","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New carborane-BODIPY conjugates: synthesis, photochemical properties and tumor cell photodamage.","authors":"Andrei V Zaitsev, Alina A Markova, Minh Tuan Nguyen, Anton V Makarenkov, Anna V Shibaeva, Ivan D Burtsev, Anton E Egorov, Alexander F Smol'yakov, Elena G Kononova, Vladimir A Kuzmin, Alexander A Shtil, Valentina A Ol'shevskaya","doi":"10.1039/d5ob01238d","DOIUrl":"https://doi.org/10.1039/d5ob01238d","url":null,"abstract":"<p><p>4,4-Difluoro-4-bora-3<i>a</i>,4<i>a</i>-diaza-<i>s</i>-indacene systems (BODIPY) are widely investigated fluorophores. The BODIPY core allows for introducing substituents at different positions. Taking advantage of the versatile properties of carborane cages for the modification of photoactive compounds, we developed the synthesis of carborane-substituted BODIPYs. The regioselective nucleophilic S_NAr aromatic substitution of the <i>para</i>-fluorine atom in 3,5-dipyrrolyl-8-pentafluorophenyl BODIPY 1 with 9-mercaptocarboranes yielded 8-carborane-substituted BODIPYs. Furthermore, the CuAAC reaction of BODIPY propargyl-substituted pyrroles with carboranylazides afforded boronated BODIPY triazoles. Derivatives with <i>m</i>-carboranyl substituents accumulated in HCT116 cells but lost their fluorescence, whereas <i>o</i>-carboranyl analogues retained fluorescence, an effect attributable to a higher affinity toward albumin and phospholipid-derived liposomes. Laser confocal microscopy analyses demonstrated that selected mono- and dicarboranyl derivatives induced lipid peroxidation upon 633 nm light illumination, leading to non-necrotic cell death. These features of cell photodamage were attributed to the ability of the carborane moiety to prevent aggregation of the BODIPY containing compounds in aqueous media and to spatially limit lipid peroxidation, thereby preserving membrane integrity. Thus, <i>closo</i>-carboranyl substituents at the BODIPY core differentially modulate the fluorescent properties and the photodamaging potency of conjugates.</p>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymer solution flow transitions and scaling laws for changing contraction ratios in planar constriction microchannels.","authors":"Mahmud Raihan, Matthew Markovetz, David Hill, Yongxin Song, Xiangchun Xuan","doi":"10.1039/d5sm00688k","DOIUrl":"https://doi.org/10.1039/d5sm00688k","url":null,"abstract":"<p><p>Pores scale flows through contractions and expansions are relevant in geoengineering, microfluidics and material processing <i>etc.</i> These flows experience shearing and extensional kinematics near constrictions, where polymer solutions may demonstrate instabilities that arise from the fluid's nonlinear rheological characteristics even in creeping flows. The relative effect of shearing and extension can be controlled by the flow geometry. Following our earlier reports on the constriction length (M. K. Raihan <i>et al.</i>, <i>Soft Matter</i>, 2021, <b>17</b>, 9198-9209) and depth (M. K. Raihan <i>et al.</i>, <i>Soft Matter</i>, 2022, <b>18</b>, 7427-7440), we investigate here the flow responses to changing constriction width and in turn contraction ratio, CR, of the main channel width to the constriction width in planar constriction microchannels. We test water and three polymer solutions including shear thinning xanthan gum, viscoelastic polyethylene oxide (PEO), and shear thinning/viscoelastic polyacrylamide solutions. Overall, the contraction and expansion flows in all tested fluids demonstrate destabilization with increasing CR except for the PEO solution, where the threshold Reynolds number for the onset of contraction flow instability first increases and then decreases. Such nonmonotonic CR dependence is also observed from the vortex length in the contraction PEO flow. In contrast, the vortex length for every other case has a fixed-order (either zero or a positive number based on fluid rheology) dependence on CR. The insights obtained here will benefit the designing of lab-on-a-chip devices as well as the harnessing of pore-scale flows for enhanced mixing, material recovery and sequestration purposes.</p>","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delithiation effects on the structural, electronic, and electrical properties of LiSr0.8Fe0.1Ni0.1PO4 material","authors":"A. Mabrouki, Olfa Messaoudi, Lamia Trabelsi, Moufida Mansouri and Latifah Alfhaid","doi":"10.1039/D5RA02943K","DOIUrl":"https://doi.org/10.1039/D5RA02943K","url":null,"abstract":"<p >In the scope of designing Li-ion batteries with increased energy density, developing new high-performance, stable, and inexpensive cathode materials remains a significant challenge. In this context, the LiSr<small>_0.8</small>Ni<small>_0.1</small>Fe<small>_0.1</small>PO<small>₄</small> material was synthesized and systematically investigated. Using Density Functional Theory (DFT) calculations, the structural stability and electronic structure were investigated during the delithiation process. The results indicate the stability of the compound during the deintercalation process and revealed a change from semiconducting to semi-metallic behavior. The expected voltage window for this material is between 3.4 and 3.25 V. A comprehensive electrical study was conducted to analyze the conduction mechanism, which is governed by the correlated barrier hopping (CBH) model below 370 K, and the non-overlapping small polaron tunneling (NSPT) model above 370 K. The consistent values of the estimated activation energy related to both conduction and impedance variation prove that the relaxation and conduction processes are governed by the same mechanism.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 39","pages":" 32131-32142"},"PeriodicalIF":4.6,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra02943k?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144990379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soy isoflavones improve sympathetic nervous system-driven non-alcoholic fatty liver disease through estrogen-like effects.","authors":"Jing Yang, Yuhang Zhao, Zhengjie Ye, Zhiyi Liu, Lingling Chang, Xinran Wang, Yuandong Qiao, Liquan Tong, Yonggang Cao","doi":"10.1039/d5fo01459j","DOIUrl":"https://doi.org/10.1039/d5fo01459j","url":null,"abstract":"<p><p>This study investigated the advantages of gerbils as a sympathetic nervous system (SNS)-driven model for non-alcoholic fatty liver disease (NAFLD) and evaluated the therapeutic potential of soy isoflavones (SIFs). Gerbils exhibited unique SNS characteristics, with an adrenal gland-to-kidney weight ratio 2-3 times higher than that of C57BL/6 mice and Wistar rats, demonstrating elevated levels of adrenaline (AE) and noradrenaline (NE) as well as more pronounced anxiety-like behaviors, indicating enhanced SNS activity. Additionally, gerbils possessed liver lipid metabolism and storage capacities similar to humans, along with a simple genetic background, allowing them to more accurately reflect the pathogenesis of NAFLD. This study employed ELISA, marble-burying tests, Oil Red O staining, H&E staining, laser speckle contrast imaging, TUNEL staining, immunofluorescence, and qRT-PCR to systematically evaluate the NAFLD model in gerbils and investigate the therapeutic effects and underlying mechanisms of SIFs on NAFLD. The study found that SIFs could reduce hepatic fat deposition, improve liver function, and downregulate the expression levels of cGAS and STING in the liver by modulating the ER-cGAS-STING pathway, thereby suppressing inflammatory responses. These findings confirmed the suitability of gerbils as an ideal model for studying SNS-induced NAFLD and revealed the potential therapeutic value of SIFs in ameliorating NAFLD through specific signaling pathways. This research provided important insights for a deeper understanding of NAFLD pathogenesis and the development of novel treatment strategies.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visible-light-induced three-component alkylation of 1,3,4-oxadiazoles <i>via</i> 1,5-hydrogen atom transfer (1,5-HAT).","authors":"Zhongzhen Yang, Xingqin Tian, Yafei Zhu, Tianle Huang, Yong Wu, Guanghui Lv","doi":"10.1039/d5ob01243k","DOIUrl":"https://doi.org/10.1039/d5ob01243k","url":null,"abstract":"<p><p>Herein we first reported an attractive example of visible-light-induced three-component alkylation of 1,3,4-oxadiazoles <i>via</i> 1,5-hydrogen atom transfer. A broad range of 1,3,4-oxadiazoles, hydroxamic acid derivatives and alkenes were successfully transformed into the corresponding products in satisfactory yields. The reaction is characterized by mild reaction conditions, good functional group compatibility, broad substrate scope, and simple operation procedure.</p>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in the construction of quaternary pseudoanomeric centers in <i>gem-C</i>,<i>C</i>-glycosides: from zaragozic acids to remdesivir.","authors":"Damien Hazelard, Mathieu Pascaretti, Damien Tardieu, Nicolas Kern, Philippe Compain","doi":"10.1039/d5ob01151e","DOIUrl":"https://doi.org/10.1039/d5ob01151e","url":null,"abstract":"<p><p><i>Gem-C</i>,<i>C</i>-glycosides-<i>C</i>-glycosides characterized by two carbon substituents at the pseudo-anomeric position-constitute a structurally distinctive class of glycomimetics with growing relevance in natural products and drug discovery. These motifs appear in diverse bioactive compounds such as maitotoxin, nogalamycins, zaragozic acids and remdesivir, displaying antimicrobial, anti-inflammatory, and anticancer properties. The unique architectures of <i>gem-C</i>,<i>C</i>-glycosides expand the glycochemical space and hold promise for therapeutic development. In contrast to classical <i>C</i>-glycosyl compounds, which benefit from a well-developed synthetic toolbox, the construction of <i>gem-C</i>,<i>C</i>-glycosides remains particularly demanding. This is primarily due to the dual requirement of forming a quaternary center while achieving stereocontrol at a highly congested site. The present review surveys current strategies for constructing quaternary pseudoanomeric centers in <i>gem-C</i>,<i>C</i>-glycosides, highlighting key advances, challenges, and opportunities in this evolving field. Particular attention is given to innovative methodologies that enable direct transformation from carbohydrate precursors, including novel approaches such as metal-hydride hydrogen atom transfer (MHAT) and C-H activation processes.</p>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photocatalyst-free synthesis of quinazolinones from <i>o</i>-aminobenzamides and rongalite under visible light.","authors":"Ajithkumar Arumugam, Sharmila Nokku, Amutha Selvaganesan, Venkatramaiah Nutalapati, Gopal Chandru Senadi","doi":"10.1039/d5ob00891c","DOIUrl":"https://doi.org/10.1039/d5ob00891c","url":null,"abstract":"<p><p>A photocatalyst-free method has been developed for the synthesis of quinazolinones from <i>o</i>-aminobenzamides and rongalite as a C₁ synthon under visible light for the first time. This transformation proceeds using atmospheric oxygen as the oxidant, involving the <i>in situ</i> generation of a superoxide radical anion (O₂˙^-), as supported by EPR analysis. Additionally, the formation of H₂O₂ was confirmed by UV-Vis spectrophotometric analysis. Key features of this method include broad functional group tolerance, moderate to good yields, gram-scale applicability, and a proof-of-concept demonstration of <i>N</i>-formylation using <i>p</i>-anisidine.</p>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polypyrrole functionalized (Ti3C2Tx–SnO2 NPs) nanocomposite-based hybrid capacitive electrode for electrochemical detection of Klebsiella pneumoniae","authors":"Md. Abdul Khaleque, Moumita Rahman Sazza, Selina Akter, Md. Romzan Ali, Syed Imdadul Hossain, Rahman Saidur, Mohamed Aly Saad Aly and Md. Zaved H. Khan","doi":"10.1039/D5RA03642A","DOIUrl":"https://doi.org/10.1039/D5RA03642A","url":null,"abstract":"<p >Bacterial detection is crucial for accurate clinical diagnostics and effective environmental monitoring. Particularly, <em>Klebsiella pneumoniae</em>, a pathogenic bacterium, can cause a wide range of infections, including meningitis, bloodstream infections, pneumonia, urinary tract infections, and wound or surgical site infections. Herein, a polypyrrole (PPy) functionalized Ti<small>₃</small>C<small>₂</small>T<small>_<em>x</em></small>–tin dioxide nanoparticle (SnO<small>₂</small> NPs) nanocomposite-based hybrid capacitive electrode for the electrochemical detection of <em>Klebsiella pneumoniae</em> ATCC 700603 is developed. The PPy layer was coated onto the Ti<small>₃</small>C<small>₂</small>T<small>_<em>x</em></small>–SnO<small>₂</small> NPs <em>via</em> drop-casting, followed by immobilization of bacteriophages through a potentiostatic, charge-directed chronoamperometric approach. The resulting Ti<small>₃</small>C<small>₂</small>T<small>_<em>x</em></small>–SnO<small>₂</small> NPs/PPy/phage biosensor exhibited a wide dynamic detection range of 10 to 10<small>⁶</small> CFU mL<small>⁻¹</small>, with excellent linearity confirmed by differential pulse voltammetry and electrochemical impedance spectroscopy. The nanocomposite was characterized by using a suite of techniques including FTIR, XRD, elemental mapping, cyclic voltammetry, and galvanostatic charge–discharge to understand its composition, structure, and electrochemical properties. The developed Ti<small>₃</small>C<small>₂</small>T<small>_<em>x</em></small>–SnO<small>₂</small> NPs/PPy hybrid electrode demonstrated typical supercapacitor behavior with a specific capacitance of 806.67 F g<small>⁻¹</small> at 2.0 A g<small>⁻¹</small> of current density, and exhibited exceptional cycling stability, storing 98.3% of its capacitance after 10<small>⁴</small> consecutive cycles. The selectivity of the modified electrode to detect <em>K. pneumoniae</em> while minimizing interference from various bacterial cells was assessed, exhibiting remarkable resilience, and remaining unaffected. Additionally, after eleven successive weeks of storage, the proposed sensor showed no discernible reduction current (∼98.1%), demonstrating an excellent stability. Despite the presence of background bacterial interference in the environmental sample, <em>K. pneumoniae</em> detection remained highly reliable and consistent with recovery efficiency ranging from 99.75 to 99.90%.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 39","pages":" 32041-32055"},"PeriodicalIF":4.6,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra03642a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144990370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metal–organic framework–injectable hydrogel hybrid scaffolds promote accelerated angiogenesis for in vivo tissue engineering","authors":"Sobuj Shahidul Islam, Tatsuya Dode, Soma Kawashima, Myu Fukuoka, Takaaki Tsuruoka and Koji Nagahama","doi":"10.1039/D5RA02770E","DOIUrl":"https://doi.org/10.1039/D5RA02770E","url":null,"abstract":"<p >The application of nanoscale metal–organic frameworks (MOFs) in tissue engineering is receiving increased attention. As three-dimensional scaffolding materials that provide an appropriate extracellular microenvironment supporting the survival, proliferation, and organization of cells play a key role <em>in vivo</em> tissue engineering, hybridization of nanoscale MOFs with bulk hydrogels has led to the development of nanoscale MOF–combined hydrogels. However, development of nanoscale MOF–combined hydrogel scaffolds remains challenging. Generally, since the gelation properties of injectable hydrogels are delicate, the sol–gel transition behavior could be lost due to the influence of additives. To date, little progress has been made in the development of nanoscale MOF–combined injectable hydrogel scaffolds. Herein, we propose a novel injectable hydrogel scaffold generated by combining NU-1000 nanoscale MOFs with PLGA-PEG-PLGA/LAPONITE® nanocomposite hydrogels. The resultant PLGA-PEG-PLGA/LAPONITE®/<small>L</small>-Arg@NU-1000 hybrid hydrogels exhibited sustained slow release of <small>L</small>-arginine over 1 month. The precursor solution of PLGA-PEG-PLGA/LAPONITE®/<small>L</small>-Arg@NU-1000 undergoes rapid sol–gel transition upon exposure to body temperature, enabling focal administration of the hydrogel at desired locations in the body <em>via</em> simple injection. The sustained <small>L</small>-arginine–slow release capability of the hybrid hydrogels results from the functionality of NU-1000 as a primary carrier and efficiently facilitates angiogenesis <em>in vivo</em>. The hybrid hydrogel exhibits highly specific functionality as a scaffold that cannot be achieved using NU-1000 alone or PLGA-PEG-PLGA/LAPONITE® hydrogels alone, thus indicating that the hybrid injectable hydrogels have the potential to become a new type of scaffold for tissue engineering.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 39","pages":" 32143-32154"},"PeriodicalIF":4.6,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra02770e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144990380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}