The Royal Society of Chemistry最新文献

{"title":"Reduced graphene oxide/ bismuth tungstate-based photocatalysts for enhanced dye photodegradation and photoelectrochemical water splitting†","authors":"Amr Awad Ibrahim, Doaa A. Kospa, Salah Orabi, Salma M. Abo Kamar, Ahmed A. Salah, E. A. El-Sharkawy, S. A. El-Hakam and Awad I. Ahmed","doi":"10.1039/D5RA04049C","DOIUrl":"https://doi.org/10.1039/D5RA04049C","url":null,"abstract":"<p >Semiconductor-based heterogeneous photocatalysis generates highly reactive charge carriers under solar illumination, making it a successful approach for wastewater purification and energy production applications. Herein, a simple solvothermal approach was used to generate a promising nanocomposite photocatalyst, reduced graphene oxide/bismuth tungstate (rGO/Bi<small>₂</small>WO<small>₆</small>). Various analytical tools were utilized to characterize the as-prepared catalysts. The oxidation of methylene blue (MB) and rhodamine B (RhB) dyes in the presence of solar light was performed to assess the photocatalytic activity of the rGO/Bi<small>₂</small>WO<small>₆</small> combination. Also, photoelectrochemical (PEC) water splitting as an efficient and cost-effective way of producing hydrogen from water using solar energy is tested. The effect of the calcination temperature of Bi<small>₂</small>WO<small>₆</small> and the amounts of graphene oxide on the catalytic activity was studied. After 30 minutes of exposure, the synthesised 10rGBW calcined at 700 °C (10rGBW-IV) showed good photodegradation percentages of 100.0% and 87.6% for MB and RhB dyes, respectively. Also, the larger photocurrent response intensity and lower arc radius of the electrochemical impedance of rGO/Bi<small>₂</small>WO<small>₆</small> compared to Bi<small>₂</small>WO<small>₆</small> revealed the synergistic effect on Bi<small>₂</small>WO<small>₆</small> visible light responsiveness. According to the Mott–Schottky curve, 10rGBW-IV demonstrates a larger negative shift of the Fermi level (FB = −0.08 V <em>versus</em> RHE), indicating a stronger oxidation potential for water splitting.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 33","pages":" 26608-26622"},"PeriodicalIF":3.9,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra04049c?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineered PD-L1 nanoregulators for enhanced tumor immunotherapy.","authors":"Muhammad Inam, Ke Ren, Bowen Shen, Fangyu Zhou, Liya Tian, Jie Liu, Xiao Sun","doi":"10.1039/d5bm00748h","DOIUrl":"https://doi.org/10.1039/d5bm00748h","url":null,"abstract":"<p><p>The programmed death ligand 1 (PD-L1) pathway plays a central role in enabling tumors to escape immune detection, making it a prime target for cancer immunotherapy. While immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis have shown remarkable clinical success, their therapeutic potential is constrained by significant challenges. These include immune-related opposing actions, appearance of resistance mechanisms, and inconsistent patient response rates. Addressing these limitations necessitates the development of innovative approaches to enhance treatment efficacy and safety. Nanomaterials hold considerable potential in modulating PD-L1 expression, offering advantages such as enhanced targeting precision and controlled drug delivery. In this review, we explored the impact of PD-L1 in immune evasion and its relevance to cancer immunotherapy, evaluating various nanomaterial-based approaches to regulate PD-L1 within the tumor microenvironment (TME). Additionally, we summarize and explain the potential benefits of combining these nanotechnology-based strategies with existing therapies to enhance therapeutic outcomes and deliberate the future directions for advancing nanomaterial-based approaches, as supported by preclinical and clinical evidence.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Sustainable and scalable one-pot synthesis of diaryliodonium salts.","authors":"Sayad Doobary, Leonard Kersting, Piret Villo, Marufa Akter, Berit Olofsson","doi":"10.1039/d5cc90244d","DOIUrl":"https://doi.org/10.1039/d5cc90244d","url":null,"abstract":"<p><p>Correction for 'Sustainable and scalable one-pot synthesis of diaryliodonium salts' by Sayad Doobary <i>et al.</i>, <i>Chem. Commun.</i>, 2025, <b>61</b>, 5158-5161, https://doi.org/10.1039/D5CC00774G.</p>","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Chinese maternal lifestyle during pregnancy and lactation with vitamin D levels in offspring: a multicenter retrospective cohort Jiangsu study.","authors":"Kan Ye, Wenjing Chang, Wen Zheng, Yufei Ni, Xinye Jiang, Aiping Wu, Guoqin Liu, Yelin Bao, Guoqiang Yang, Li Zhang, Hongxia Qi, Heyu Lv, Rui Qin, Yan Zhao","doi":"10.1039/d5fo01812a","DOIUrl":"https://doi.org/10.1039/d5fo01812a","url":null,"abstract":"<p><p><i>Background</i>: This study aims to investigate the association between maternal lifestyle during pregnancy and lactation and vitamin D levels in their offspring, providing insights for interventions against vitamin D deficiency. <i>Methods</i>: A stratified random cluster sampling approach was used to recruit children aged 0-5 years in Jiangsu Province. Self-designed questionnaires were utilized to explore maternal lifestyle. Subsequently, the serum 25-hydroxyvitamin D levels were quantified using the enzyme-linked immunosorbent assay technique. <i>Results</i>: We recruited 5243 mother-child pairs. Factors significantly associated with an increased risk of vitamin D deficiency in offspring included maternal vitamin D and calcium supplementation, fish and shrimp intake ≥2 times per week, and <1 hour of outdoor activity per day during pregnancy, and initiation of vitamin D and calcium supplementation after labour and delivery, daily vitamin D and calcium supplementation deficiencies, fish and shrimp intake ≥4 times per week, and <1 hour of outdoor activity per day during lactation, with OR values of 1.26, 1.47, 1.45, 2.31, 1.89, 1.49, and 1.23 and <i>β</i> values of -3.67, -10.44, -5.13, -8.64, -7.55, -5.14, and -2.73, respectively. 25-Hydroxyvitamin D levels were significantly higher in offspring of mothers who started VD and calcium supplementation at 5-12 weeks and 12 weeks or more of pregnancy and in offspring who consumed 250-500 ml of milk per day during pregnancy and 500 ml or more of milk per day by 7.60, 9.58, 8.93, and 9.36 nmol L^-1, respectively, all with <i>P</i> < 0.05. <i>Conclusion</i>: Lower levels of vitamin D in offspring were associated with higher weekly intake of fish and shrimp by mothers during pregnancy and lactation, less daily outdoor activity, vitamin D and calcium supplementation during pregnancy, supplementation started before or early in pregnancy, insufficient milk intake during pregnancy, vitamin D supplementation immediately after delivery, and lack of daily vitamin D and calcium supplementation during lactation.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive effect of a novel protein from <i>Pleurotus eryngii</i> on improving colitis: exploring potential mechanisms from the perspective of intestinal metabolism.","authors":"Xinyi Li, Qi Tao, Qiuhui Hu, Tao Hou, Yunyan Yu, Yaning Duan, Gaoxing Ma","doi":"10.1039/d5fo01832c","DOIUrl":"https://doi.org/10.1039/d5fo01832c","url":null,"abstract":"<p><p><i>Pleurotus eryngii</i> (<i>P. eryngii</i>) protein has demonstrated potential anti-inflammatory effects, but the specific mechanism has not been reported. Our research found that <i>P. eryngii</i> protein improved colitis in mice through various pathways, including reducing levels of inflammatory cytokines, promoting oxidative stress homeostasis, and enhancing immune response capacity. 16S rDNA sequencing showed that under the intervention of <i>P. eryngii</i> protein, the relative abundance of the microbiota (<i>Escherichia</i>, <i>Shigella</i>, and <i>Lachnoclostridium</i>) that induced colitis decreased. Metabolomics results showed that the metabolism of lipids and lipid-like molecules was active, with a decrease in the content of steroids (delta 8,14-sterol and DG (14 : 1 (9Z)/16 : 1 (9Z)/0 : 0)) and an increase in the content of terpenoids ((<i>Z</i>)-alpha-bergamotenoic acid, sterebin-D, and alpha-terpineol). Pathway analysis found that the <i>P. eryngii</i> protein activated the cholesterol metabolism pathway through the production of terpenoids, thus promoting the production of very low-density lipoprotein (VLDL) and bile acids, which regulated the level of IL-10 and intestinal homeostasis. Multi-omics joint analysis found that the production of steroid metabolites could be inhibited by <i>Flavonifractor</i> and <i>Sphingomonas</i>, while the growth of harmful bacteria <i>Enterococcus</i> and <i>Lachnoclostridium</i> was likely to be restrained by the terpenoid metabolites. Overall, this study has illustrated that the <i>P. eryngii</i> protein prevented the production of harmful bacteria and activated the cholesterol metabolism pathway to resist inflammatory reactions by regulating the metabolism of lipids and lipid-like molecules.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electron-deficient B-site engineering in CeNiO₃ for efficient PMS activation and tetracycline degradation.","authors":"Xin Tang, Huiwei Ding, Qiaofeng Han, Guolang Zhou, Rongyao Ma, Zhipeng Xue, Shuolei Yan, Lili Zhang, Jingzhou Yin, Edison Huixiang Ang","doi":"10.1039/d5mh01099c","DOIUrl":"https://doi.org/10.1039/d5mh01099c","url":null,"abstract":"<p><p>The efficiency of peroxymonosulfate (PMS) activation in advanced oxidation processes is often hindered by weak electronic interactions between the active sites and PMS molecules. To address this challenge, this study presents the synthesis of Fe-doped CeNiO₃ (Fe-CNO) using a combined approach of Fe doping and a metal-organic framework (MOF)-derived strategy. The core innovation involves the introduction of Fe to induce electron-deficient B-site engineering, which strategically reconstructs the electronic structure of the original Ni sites, converting them into highly active, electron-deficient centers. Both experimental and theoretical investigations confirm that these modified centers exhibit reduced electron cloud density, thereby significantly strengthening their interaction with PMS. This enhancement facilitates an optimized electron transfer pathway, lowers the activation energy barrier for O-O bond cleavage, and promotes the generation of diverse reactive oxygen species (ROS). Concurrently, the MOF-derived architecture imparts a high specific surface area to Fe-CNO, and the increased density of active sites synergistically accelerates PMS activation. Fe-CNO achieved a TC degradation efficiency exceeding 90% within 60 minutes <i>via</i> PMS activation, nearly three times higher than that of pristine CeNiO₃. Furthermore, it exhibited minimal metal leaching (<0.07 mg L^-1), excellent pH tolerance (pH = 4-12), and strong cycling stability. This work provides an effective approach for designing novel, stable, and environmentally friendly catalysts and offers valuable insights into the use of CeNiO₃-based perovskites in AOPs.</p>","PeriodicalId":87,"journal":{"name":"Materials Horizons","volume":" ","pages":""},"PeriodicalIF":12.2,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in flexible and wearable OLEDs for biomedical applications: a review.","authors":"Eun Hae Cho, Young Woo Kim, Junhee Sim, Hyejeong Yeon, Sooyeon Baek, Seung Min Jeong, Junwoo Lee, Yongmin Jeon, Kyung Cheol Choi","doi":"10.1039/d5mh00742a","DOIUrl":"https://doi.org/10.1039/d5mh00742a","url":null,"abstract":"<p><p>Light-based therapies and diagnostics have gained prominence in medicine due to their non-invasive approach and therapeutic efficacy. Among these technologies, organic light-emitting diodes (OLEDs) are emerging as promising platforms in healthcare, offering advantages such as mechanical flexibility, lightweight construction, and efficient surface emission. Initially developed for display applications, OLEDs have been adapted for biomedical use, enabling conformal integration onto the skin or within the body. Here, we present recent advances in OLED technologies for biomedical applications, focusing on the development and optimization of OLEDs to meet the specific requirements of biomedical use. Developments in device platforms-utilizing flexible substrates and free-form architectures-are discussed, enabling the realization of wearable and implantable systems. Applications are categorized based on functional mechanisms of light-based stimulation and sensing, including photobiomodulation (PBM), photodynamic therapy (PDT), optogenetics, and biosensing. Finally, we conclude by outlining key remaining challenges in the development of OLEDs for biomedical applications.</p>","PeriodicalId":87,"journal":{"name":"Materials Horizons","volume":" ","pages":""},"PeriodicalIF":12.2,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decarbonative routes to generate <i>N</i>-acyliminium ion intermediates for the synthesis of 3-substituted isoindolinones <i>via</i> an intermolecular amidoalkylation reaction.","authors":"Nazir Uddin, Sudipta Roy, Santanab Giri, Gitish K Dutta, Paresh Nath Chatterjee","doi":"10.1039/d5ob00687b","DOIUrl":"https://doi.org/10.1039/d5ob00687b","url":null,"abstract":"<p><p>An alternative and unique approach for synthesizing 3-substituted isoindolinones <i>via</i> Lewis acid-catalyzed C-C bond-breaking reactions has been reported. For this purpose, we successfully generated <i>N</i>-acyliminium ion intermediates from two different substrates [through (a) an FeCl₃ catalyzed C_sp3-C_sp2 bond-breaking reaction in isoindolinones bearing electron-rich and sterically bulky aryl substituents at the 3-position and (b) a ZnCl₂ catalyzed C_sp3-C_sp3 bond-breaking reaction in isoindolinones bearing 1,3-diketo substituents at the 3-position of the isoindolinone starting precursors], which were trapped by appropriate nucleophiles to produce more stable γ-substituted isoindolinones in good to excellent yields. The leaving ability of 1,3-diketones is higher than that of electron-rich and sterically bulky arenes in our developed method, which results in higher yields of γ-substituted isoindolinones from the starting precursor bearing the 1,3-diketo substituents at its 3-position. Theoretical investigations were also carried out to gain insight into the two different C-C bond-cleaving reactions.</p>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a size exclusion chromatography cartridge-based analytical method for determination of free drug in nano-liposomal oncology drug formulations.","authors":"Wei Zhang, Mark Paciolla, Lijun Duan, Elise Bradley, Aastha Chadha, Bhavesh Barot, Kaylee Worrell","doi":"10.1039/d4ay02124j","DOIUrl":"https://doi.org/10.1039/d4ay02124j","url":null,"abstract":"<p><p>A reliable and stability-indicating size exclusion chromatography (SEC) cartridge-based free drug testing method was developed for active loading nanoliposome formulations through a systematic development approach. The SEC spin cartridge columns (7K MWCO, 2 mL) were used for developing the liposome free drug testing procedure. The SEC cartridge column retention capacity for a Mirati drug was determined (445 μg per cartridge). SEC testing conditions were studied to achieve a good separation between liposomes and the free drug, including cartridge conditioning, buffer wash steps for liposomal drug elution, organic media wash steps for free drug elution, and sample size effect. Qualification of this newly developed SEC cartridge method has demonstrated its specificity/selectivity without interference and excellent detection linearity (correlation coefficient (<i>R</i>) > 0.999) over a study concentration range (1.0 to 46.9 μg mL^-1), sufficient LOQ (0.52 μg mL^-1 equivalent to 1.7% of free drug in a liposome formulation at 2.5 mg mL^-1), acceptable accuracy/recovery of 81 to 89% for free drug in spiked samples at 4.5%, 9%, and 18% levels (sample loading by a regular pipet) and 88 to 97% at 10% spike level (sample loading by a positive displacement pipet), good method precision (RSD (<i>n</i> = 6) of 4% NMT) for free drug determination, and 3 days solution stability for both standard and sample solutions (2-8 °C). In comparative sample testing, the SEC free drug test results were in good agreement with the solid phase extraction (SPE) test results for active loading formulations. The new method's stability-indicating ability has been proved through monitoring free drug in a liposome sample stored at -20 °C and -80 °C.</p>","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Foodomics within the field of colorectal cancer prevention, diagnosis and treatment.","authors":"Yingyu Zhou, Long Teng, Elena Ibáñez, Hongsheng Chen, Alejandro Cifuentes, Weihong Lu","doi":"10.1039/d5fo00451a","DOIUrl":"https://doi.org/10.1039/d5fo00451a","url":null,"abstract":"<p><p>Colorectal cancer (CRC) is a significant global health challenge with high incidence and mortality rates. Foodomics, an interdisciplinary field combining food science with omics technologies, offers a comprehensive approach to understanding diet-CRC interactions. This review highlights the role of Foodomics in CRC prevention, diagnosis, and treatment. For prevention, Foodomics identifies bioactive dietary components such as quercetin in apples and curcumin in turmeric that can modulate gene expression and signaling pathways to reduce cancer risk. In diagnosis, metabolomics and transcriptomics are used to identify biomarkers like short-chain fatty acids (SCFAs) and specific gene transcripts (<i>e.g.</i>, SEPT9, GSTM3) that can serve as indicators for CRC presence, enabling non-invasive screening. For treatment, Foodomics integrates personalized nutrition with targeted therapies, enhancing chemotherapeutic efficacy and modulating the tumor microenvironment through dietary interventions. Despite challenges in data standardization and clinical translation, Foodomics holds great promise for advancing CRC management through precision nutrition and optimized dietary interventions. Future directions include developing standardized protocols for data analysis, validating Foodomics-based interventions through clinical trials, and training healthcare professionals in Foodomics applications.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}