The Royal Society of Chemistry最新文献

{"title":"Discovery, biosynthesis, and bioactivities of peptidic natural products from marine sponges and sponge-associated bacteria.","authors":"Weimao Zhong, Zhenjian Lin, Eric W Schmidt, Vinayak Agarwal","doi":"10.1039/d5np00048c","DOIUrl":"10.1039/d5np00048c","url":null,"abstract":"<p><p>Covering 2010 to 2025Sponges are benthic, sessile invertebrate metazoans that are some of the most prolific sources of natural products in the marine environment. Sponge-derived natural products are often endowed with favorable pharmaceutical bioactivities, and paired with their structural complexity, have long served as title compounds for chemical syntheses. Sponges are holobionts, in that the sponge host is associated with symbiotic and commensal microbiome. Natural products isolated from sponges can be produced by the sponge host, or the associated microbiome. Recent genomic studies have shed light on the sponge eukaryotic host as the true producer of several classes of sponge-derived peptidic natural products. In this review spanning years 2010-2025, we describe peptidic natural products isolated from the sponge hosts and the associated microbiome, detail their biosynthetic processes where known, and offer forward looking insights into future innovation in discovery and biosynthesis of peptidic natural products from marine sponges.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12426817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145038650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design of Ni-modified ZnSe nanostructures embedded in rGO for efficient supercapacitor electrodes","authors":"Sana Ullah Asif, Abdul Shakoor, Bushra Asghar, Abdul Waheed, Abdullah K. Alanazi, Muhammad Ehsan Mazhar, Shahid Atiq, Muhammad Yahya Haroon, Sadia, Abdul Qayyum, Waseem Abbas, Zainab Bano and Farooq Ahmad","doi":"10.1039/D5RA05161D","DOIUrl":"https://doi.org/10.1039/D5RA05161D","url":null,"abstract":"<p >Energy crises have prompted researchers to develop new electrode materials for efficient energy storage, leading to the creation of effective energy storage devices. Therefore, this study introduces Ni-doped ZnSe/rGO-based materials fabricated through a hydrothermal synthesis method, which demonstrated enhanced electrical and electrochemical performance. X-ray diffraction (XRD) analysis revealed an increase in the crystallite size from 49.72 nm to 96.74 nm, accompanied by a corresponding growth in the particle size, which can be attributed to the incorporation of Ni and rGO as substituents. The electrochemical characterization of all fabricated electrodes indicated that the best-performing Zn<small>_0.90</small>Ni<small>_0.10</small>Se/rGO composite achieved a high specific capacitance of 1920.20 F g<small>⁻¹</small> at 5 mV s<small>⁻¹</small>, significantly surpassing that of pure ZnSe (346.8 F g<small>⁻¹</small>), as determined from CV measurements. Additionally, the Zn<small>_0.90</small>Ni<small>_0.10</small>Se/rGO electrode demonstrated excellent cycling stability (90.85% capacitance retention after 10 000 cycles), a high power density of 3500 W kg<small>⁻¹</small> at a current density of 7 A g<small>⁻¹</small>, and an energy density of 83.81 Wh kg<small>⁻¹</small> at a current density of 1 A g<small>⁻¹</small>, with a storage capability of 1058.75 F g<small>⁻¹</small>. The combined effect of Ni and rGO doping in the composites resulted in a notable reduction in series and charge transfer resistances. Under optimal conditions, it exhibited excellent electrochemical performance, as indicated by good ionic conductivity (0.037 S cm<small>⁻¹</small>), the highest transference number for cations (0.90), and a rate constant of 1.42 × 10<small>⁻⁸</small> cm s<small>⁻¹</small> at an exchange current density of 0.00137 A g<small>⁻¹</small>, as well as a diffusion coefficient of 8.03 × 10<small>⁻¹³</small> m<small>²</small> s<small>⁻¹</small>, suggesting enhanced ion transport characteristics. These promising attributes of Zn<small>_0.90</small>Ni<small>_0.10</small>Se/rGO strongly demonstrate it as an ideal electrode material for advanced energy storage applications.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 40","pages":" 33374-33389"},"PeriodicalIF":4.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra05161d?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction: Surface modified composite nanofibers for the removal of indigo carmine dye from polluted water","authors":"M. G. Yazdi, M. Ivanic, Alaa Mohamed and A. Uheida","doi":"10.1039/D5RA90104A","DOIUrl":"https://doi.org/10.1039/D5RA90104A","url":null,"abstract":"<p >Retraction of ‘Surface modified composite nanofibers for the removal of indigo carmine dye from polluted water’ by M. G. Yazdi <em>et al.</em>, <em>RSC Adv.</em>, 2018, <strong>8</strong>, 24588–24598, https://doi.org/10.1039/C8RA02463D.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 40","pages":" 33188-33188"},"PeriodicalIF":4.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra90104a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous determination of genotoxic nitrosamine impurities in sitagliptin/metformin combination tablets: comparative evaluation of ionisation techniques coupled with LC-MS/MS and high-resolution mass spectrometry.","authors":"Hyojeong Lee, Minki Shim, Seungjin Jung, Sang Beom Han, Dong-Kyu Lee","doi":"10.1039/d5ay01001b","DOIUrl":"https://doi.org/10.1039/d5ay01001b","url":null,"abstract":"<p><p>Genotoxic nitrosamine impurities have increasingly posed substantial safety concerns for pharmaceutical formulations, particularly sitagliptin/metformin combination tablets. In particular, <i>N</i>-nitrosodimethylamine (NDMA) and 7-<i>N</i>-nitroso-3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-<i>a</i>]pyrazine (NTTP)-a newly identified nitrosamine drug-substance-related impurity (<i>N</i>-nitroso-sitagliptin or <i>N</i>-nitroso-STG-19)-have been detected in these pharmaceutical formulations. However, there are no established analytical methods addressing the simultaneous quantification of these two distinct classes of nitrosamine impurities in a single analysis. Therefore, we aimed to develop and validate a robust analytical approach utilising liquid chromatography-mass spectrometry (LC-MS) coupled with atmospheric-pressure chemical ionisation (APCI). Comparison of the ionisation modes and mass analysers revealed that LC-APCI-MS significantly outperformed electrospray ionisation for NDMA, whereas both ionisation methods were suitable for NTTP. Furthermore, both high-resolution quadrupole time-of-flight and triple quadrupole mass spectrometry platforms met the regulatory validation criteria, with excellent linearity (<i>R</i>² > 0.997), recovery (95-102%), and precision (RSD < 5.7%) observed across both instruments. In contrast, GC-MS analysis, one of the major methods for NDMA or nitrosamine detection, was unsuitable for NTTP quantification because of inadequate volatility and chromatographic resolution. As sitagliptin/metformin remains the primary therapy for type 2 diabetes, the proposed method offers a practical solution for quality control monitoring and ensures a safe and stable supply of this widely used combination product.</p>","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145038839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nickel-catalyzed reductive cross-coupling of aziridines and benzyl chlorides.","authors":"Jie Wan, Sen-Lin Wang, Cheng-Ke Liu, Yu-Lu Chen, Hai-Liang Ni, Peng Cao, Ping Hu, Bi-Qin Wang, Bin Chen","doi":"10.1039/d5ob01299f","DOIUrl":"https://doi.org/10.1039/d5ob01299f","url":null,"abstract":"<p><p>A nickel-catalyzed reductive cross-coupling of aziridines and benzyl chlorides was realized by using manganese metal as the reducing agent. This protocol afforded a convenient approach for obtaining β-benzyl-substituted arylethylamines bearing various functional groups. The utility of this reaction was also demonstrated by their straightforward conversion to privileged tetrahydroisoquinoline derivatives.</p>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145038627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controlling electrochemical lignin depolymerization via halide chemistry at boron-doped diamond electrodes","authors":"Busarakham Ngokpho, Pattarawadee Therdkatanyuphong, Panot Krukkratoke, Tanatorn Khotavivattana, Apichat Boontawan and Kamonwad Ngamchuea","doi":"10.1039/D5RA05524E","DOIUrl":"https://doi.org/10.1039/D5RA05524E","url":null,"abstract":"<p >Lignin, a highly abundant yet underutilized biopolymer, holds significant potential as a renewable source of aromatic chemicals. Herein, we present a sustainable electrochemical approach for lignin valorization, in which oxidative pathways are tunable <em>via</em> halide redox chemistry. Using boron-doped diamond electrodes, chosen for their wide potential window, high current efficiency, and fouling resistance, we elucidate the roles of halide (Cl<small>⁻</small>, Br<small>⁻</small>, I<small>⁻</small>) and membrane configuration in governing electrochemical reactivity, selectivity, and surface stability. Cyclic voltammetry and extended electrolysis reveal distinct regimes: chloride and bromide mediate direct electrode-driven oxidation which suffers from surface passivation, whereas iodide enables solution-phase oxidation <em>via</em> electrogenerated iodine species, minimizing fouling and delivering the highest yield of aromatic products. Product analysis confirms β-O-4 cleavage as the dominant depolymerization route, with vanillin as the primary product. Incorporation of a cation-exchange membrane substantially enhances yields and promotes deeper oxidative transformations, such as the formation of isovanillic and furan carboxylic acids. These findings define key parameters for achieving sustainable and tunable electrochemical lignin conversion without the need for sacrificial oxidants.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 40","pages":" 33209-33223"},"PeriodicalIF":4.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra05524e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145036975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In situ growth of luminescent lanthanide coordination nanoparticles inside living plants","authors":"Xinnan Wang, Chunyu Zhao, Qi Wang, Xiaowen Wang, Tao Chen, Xinyue Yang, Keyi Guo and Qi Zhou","doi":"10.1039/D5RA04355G","DOIUrl":"https://doi.org/10.1039/D5RA04355G","url":null,"abstract":"<p >Lanthanide coordination nanoparticles have drawn considerable attention owing to their outstanding luminescence properties. However, biosynthesis of lanthanide coordination nanoparticles is a relatively new and poorly explored area. Plants possess complex passive fluid transport systems and are potential green nanofactories for the synthesis of nanomaterials. In this study, luminescent lanthanide coordination nanoparticles with various morphologies were synthesized from various living plants. The two-step process involved incubating plant clippings or intact plants in <em>p</em>-phthalic acid (PTA) solution, followed by washing and subsequent incubation in lanthanide ion (Eu<small>³⁺</small> and Tb<small>³⁺</small>) solution. Different types of plants and lanthanide ions led to the formation of lanthanide coordination nanoparticles of different shapes and sizes. Specifically, the Eu/PTA and Tb/PTA coordination nanoparticles inside <em>shamrock</em> and <em>epipremnum aureum</em> revealed spherical, rod-shaped, octahedral, cubic, and rectangular crystals with sizes in the nanometer and micrometer ranges. Moreover, luminescent <em>shamrocks</em> with red, green, and even yellow emissions were obtained using Eu<small>³⁺</small>, Tb<small>³⁺</small>, and a mixture. Finally, the intact <em>shamrocks</em> with luminescent Eu/PTA and Tb/PTA coordination nanoparticles were used for the <em>in situ</em> detection of Cu<small>²⁺</small> in water. The integration of functional lanthanide coordination nanoparticles into living plants is a promising innovation in nanobionics that could open the door to advanced sensors and other applications.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 40","pages":" 33224-33228"},"PeriodicalIF":4.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra04355g?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145036976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced thermoelectric performance of yttrium-doped ZnO ceramics via secondary phase formation and conventional sintering","authors":"Aisha Saleem, Sajid Butt, Muhammad Irfan, Muhammad Faizan Masoud, Sumayya, Muhammad Umer Iqbal, Naseem Iqbal, Abdul Faheem Khan and Muhammad Abdul Basit","doi":"10.1039/D5RA03749B","DOIUrl":"https://doi.org/10.1039/D5RA03749B","url":null,"abstract":"<p >Zinc oxide (ZnO)-based ceramics have been widely studied for thermoelectric applications due to their abundance, non-toxicity, cost-effectiveness, thermal stability, and high Seebeck coefficient. In this work, a series of yttrium (Y)-doped ZnO samples was synthesized using the sol–gel method followed by conventional sintering. The thermoelectric property measurements coupled with detailed structural characterization were systematically performed to establish a structure–property relationship. The X-ray diffraction (XRD) analysis confirms limited substitution of Y at the Zn-site in the lattice of ZnO. The surplus Y-doping results in the formation of the secondary phase Y<small>₂</small>O<small>₃</small>. The sample with composition Zn<small>_0.98</small>Y<small>_0.02</small>O exhibited the highest power factor and figure of merit (<em>ZT</em>) values of 0.47 μW cm<small>⁻¹</small> K<small>⁻²</small> and 5.6 × 10<small>⁻⁵</small>, respectively, at 575 K. The outlined study elucidates the effects of Y-doping in ZnO to understand the underlying transport phenomenon in ZnO ceramics.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 40","pages":" 33365-33373"},"PeriodicalIF":4.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra03749b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in photoinduced amidyl radical-mediated remote C(sp³)-H activation <i>via</i> 1,5-hydrogen atom transfer.","authors":"Min Liao, Yuanyuan Li, Meiling Ye, Chunjuan Liu","doi":"10.1039/d5ob01197c","DOIUrl":"https://doi.org/10.1039/d5ob01197c","url":null,"abstract":"<p><p>C-H bonds are widely present in organic molecules and play a crucial role in chemical diversification. Among them, the functionalization of unactivated C(sp³)-H bonds is highly challenging. The 1,5-hydrogen atom transfer (1,5-HAT) strategy offers an avenue for the functionalization of remote inert C-H bonds with excellent regioselectivity and chemoselectivity. This review looks back at the history and mechanism of the Hofmann-Löffler-Freytag (HLF) reaction and highlights the recent advances in the functionalization of remote inert C(sp³)-H bonds triggered by nitrogen-centered radicals (NCRs) <i>via</i> photoinduced 1,5-hydrogen atom transfer processes.</p>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145038685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promoting the viability of soybean biodiesel by mitigating its oxidative effects on austenitic stainless steel using a natural additive of spent coffee grounds","authors":"Maha El Hawary, Othon S. Campos, Younes Kerroum, Abdelkbir Bellaouchou, Hatem M. A. Amin and Maria Boudalia","doi":"10.1039/D5RA04888E","DOIUrl":"https://doi.org/10.1039/D5RA04888E","url":null,"abstract":"<p >This work demonstrates the recycling potential of a hydroalcoholic extract of spent coffee waste (HECG) as an environmentally friendly additive to soybean cooking oil (SWCO) biodiesel, alleviating its corrosive impacts on a Cr-rich stainless-steel alloy. The extract is efficiently produced using the Soxhlet extraction method, and its chemical profile is analyzed using GC-MS and FTIR. Furthermore, the anticorrosive properties of HECG are thoroughly evaluated using gravimetry, potentiodynamic polarization, and electrochemical impedance spectroscopy (EIS). The HECG additive shows excellent inhibitory efficacy (94%) on 307 L stainless steel. The polarization results underline the mixed inhibitory character of HECG. The metal surface is primarily protected against biodiesel-induced corrosion through adsorption of additive molecules onto it. Additionally, SEM-EDX and XRD techniques are used to evaluate the microstructure, crystal structure, and composition of the surface and formed products after immersion in this biodiesel. The results showcase the additional protection of the 307 L sample via creating a passive oxide film (CrO<small>₂₃</small>, FeO<small>₂₃</small>, FeOOH) on the metal surface, thus boosting its corrosion resistance. Importantly, DFT and Fukui function simulations identify the electrophilic and nucleophilic sites at the β-turmerone molecule, the major component of the extract, and reveal intrinsic retro donations in both ways – additive to metal and/or metal to additive.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 40","pages":" 33297-33311"},"PeriodicalIF":4.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra04888e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145036999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}