The Royal Society of Chemistry最新文献_第3页

Molecular aptamer beacon-based dual-mode exponential isothermal amplification for microRNA detection. 基于分子适体信标的双模指数等温扩增检测microRNA。

IF 2.9 3区化学

Organic & Biomolecular Chemistry Pub Date : 2025-07-25 DOI: 10.1039/d5ob00962f

Yu Han, Xuefeng Bian, Xiao Wang, Jiaying Chen, Liu Han, Xin Sun

{"title":"Molecular aptamer beacon-based dual-mode exponential isothermal amplification for microRNA detection.","authors":"Yu Han, Xuefeng Bian, Xiao Wang, Jiaying Chen, Liu Han, Xin Sun","doi":"10.1039/d5ob00962f","DOIUrl":"https://doi.org/10.1039/d5ob00962f","url":null,"abstract":"Due to the limiting factors associated with microRNAs (miRNAs), including their low abundance, short sequence length, and high family sequence homology, the gold standard for miRNA detection does not meet the requirements for rapid and low-cost clinical detection of miRNAs in biological samples. To this end, we developed a one-pot method called molecular aptamer beacon-utilized exponential isothermal amplification (MABEXIA) for analyzing and detecting miRNAs. This novel devolved method was analyzed using both a fluorescent dye and a horseradish peroxidase (HRP) mediated chemiluminescence reaction with luminol and hydrogen peroxide for miRNA detection. The principle of the fluorescence platform involves hybridization of the target miRNA with MAB, which results in the formation of a large amount of double-stranded (ds) DNA products under the dual catalytic action of a DNA polymerase (Klenow Fragment) and nicking endonuclease (Nb.BbvCI) at a constant temperature. Moreover, this method exhibited good detection performance and was successfully applied to 1% human serum for miRNA detection. In contrast to the fluorescence method, the chemiluminescence approach achieved miRNA detection through the targeted interaction between the activated streptavidin (SA) aptamer within the dsDNA product and SA-coated magnetic beads. This method showed a good linear relationship in the ranges of 50 fM to 50 pM for miRNA detection. Finally, this chemiluminescence approach has a detection ability comparable to that of the gold standard for miRNA detection.","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Packed-nanofiber solid phase extraction for daidzein, genistein, glycitein in human urine and their simultaneous detection† 填充纳米纤维固相萃取人尿中大豆苷元、染料木素、糖苷元及其同时检测研究

IF 3.9 3区化学

RSC Advances Pub Date : 2025-07-25 DOI: 10.1039/D5RA03046C

Yuqi Dai, Lanmei Zhang, Yuemeng Wang, Anni Fu, Lanling Chu and Lei Zhao

{"title":"Packed-nanofiber solid phase extraction for daidzein, genistein, glycitein in human urine and their simultaneous detection†","authors":"Yuqi Dai, Lanmei Zhang, Yuemeng Wang, Anni Fu, Lanling Chu and Lei Zhao","doi":"10.1039/D5RA03046C","DOIUrl":"https://doi.org/10.1039/D5RA03046C","url":null,"abstract":"In this work, an integrated method based on the novel packed-fiber solid-phase extraction (PFSPE) combined with high-performance liquid chromatography-ultraviolet detector (HPLC-UV) detection system was proposed for the detection of daidzein, genistein and glycitein in human urine. To efficiently adsorb three kinds of isoflavones in biological fluid, polystyrene-based nanofibers were prepared and used as adsorbents in customized solid phase extraction devices. The composition of the nanofibers, the amount of different salt ions added, the type of eluent, and the interaction of eluent volume, the amounts of nanofibers added, and the extraction time were analyzed to find the optimal adsorption conditions, respectively. The method of optimal extraction conditions for the analysis of three soy isoflavones exhibited low limits of detection (LOD) and limits of quantitation (LOQ) of 1.68–2.74 μg L−1 and 5.09–8.3 μg L−1, respectively, and spiked recovery of 95.2–107.1%, and has been successfully applied to human urine samples. This study demonstrated the potential of PFSPE as methods for the adsorption and detection of daidzein, genistein, glycitein in biological fluid concurrently, providing a valuable tool for pharmacokinetic studies and investigations into the metabolism and bioavailability of isoflavones.","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 33","pages":" 26601-26607"},"PeriodicalIF":3.9,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra03046c?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144695671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cyclic perturbations facilitate athermal creep in yield-stress materials. 循环扰动促进屈服应力材料的非热蠕变。

IF 2.9 3区化学

Soft Matter Pub Date : 2025-07-25 DOI: 10.1039/d5sm00186b

Ezequiel E Ferrero, Eduardo A Jagla

{"title":"Cyclic perturbations facilitate athermal creep in yield-stress materials.","authors":"Ezequiel E Ferrero, Eduardo A Jagla","doi":"10.1039/d5sm00186b","DOIUrl":"https://doi.org/10.1039/d5sm00186b","url":null,"abstract":"Yield stress materials deform irreversibly at a finite strain-rate if loaded with a fixed stress σ larger than some critical yield stress σc. When σ < σc deformation is absent, except for transient or thermally activated processes. However, the cyclic temporal variation of system parameters can induce a persistent irreversible deformation under sub-critical athermal conditions. We characterize this phenomenon using well established models in the fields of the yielding and depinning transitions. We find that the amount of deformation per cycle increases if σc is approached from below, and it decreases and even vanishes at a novel critical stress σ0 < σc when this is reached from above. Interestingly, σ0 plays a role similar to the fatigue limit in the context of fatigue damage propagation. Our study is inspired by the literature on soft Earth geophysics where soil creep mechanisms have been correlated with cyclic changes of environmental conditions, such as daily or seasonal fluctuations in temperature and humidity, which in turn promote fluctuations in the systems internal mechanical properties. We believe our findings can motivate an interdisciplinary perspective on the study of sub-critical landform evolution, as the creep of hill slopes over long periods of time.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-consistent field description of polyelectrolyte-grafted colloidal actuators. 聚电解质接枝胶体致动器的自洽场描述。

IF 2.9 3区化学

Soft Matter Pub Date : 2025-07-25 DOI: 10.1039/d5sm00474h

Eleonora Foschino, Irene E Hulsen, Alessandro Ianiro, Remco Tuinier, Mark Vis

{"title":"Self-consistent field description of polyelectrolyte-grafted colloidal actuators.","authors":"Eleonora Foschino, Irene E Hulsen, Alessandro Ianiro, Remco Tuinier, Mark Vis","doi":"10.1039/d5sm00474h","DOIUrl":"https://doi.org/10.1039/d5sm00474h","url":null,"abstract":"We present a theoretical description of actuators in prototype artificial muscle tissue by means of a self-consistent (mean field) lattice computational scheme. The actuators are composed of pH-responsive polyelectrolytes grafted at both ends between plate- or rod-like colloidal particles and immersed in an aqueous solution. We build on a model developed for grafted rods [A. Ianiro, J. A. Berrocal, R. Tuinier, M. Mayer and C. Weder, J. Chem. Phys., 2023, 158, 14901], but we specifically include weakly acidic monomers to incorporate the effects of a pH variation to trigger the expansion of the material. As a first toy model, we consider strong polyelectrolyte chains: for both plate- and rod-like colloidal particles, we obtain pressure differences of the order of tens of MPa; sufficient to generate volume variation. During actuation, the system expands and contracts by approximately one third of the polymer contour length and about 100kT of work per polymer chain is performed. Secondly, we show that for weakly charged polyelectrolyte chains the salt concentration can be used to tune the actuation window by multiple pH units, which is important to obtain a biocompatible range of pH values. In this scenario, we find smaller actuation pressures than for strong polyelectrolytes, but still sufficient expansion and contraction for practical purposes.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Golgi-targeting fluorescent probe for the detection of hydrazine in biological and environmental systems. 用于生物和环境系统中肼检测的高尔基靶向荧光探针。

IF 2.7 3区化学

Analytical Methods Pub Date : 2025-07-25 DOI: 10.1039/d5ay00690b

Hui-Juan Lai, Xu Wang, Yuan Wang, Wei-Na Wu, Zhi-Hong Xu

引用次数: 0

Outstanding Reviewers for Biomaterials Science in 2024. 2024年生物材料科学杰出审稿人。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2025-07-25 DOI: 10.1039/d5bm90056e

引用次数: 0

Unraveling interfacial interactions in reduced Nb₂CT_x/GO heterostructures for highly stable and transparent narrow-band photoelectrochemical photodetectors. 高稳定透明窄带光电电化学探测器中还原Nb2CTx/GO异质结构的界面相互作用。

IF 8 2区材料科学

Nanoscale Horizons Pub Date : 2025-07-25 DOI: 10.1039/d5nh00280j

Muhammad Abiyyu Kenichi Purbayanto, Subrata Ghosh, Dorota Moszczyńska, Carlo S Casari, Agnieszka Maria Jastrzębska

{"title":"Unraveling interfacial interactions in reduced Nb2CTx/GO heterostructures for highly stable and transparent narrow-band photoelectrochemical photodetectors.","authors":"Muhammad Abiyyu Kenichi Purbayanto, Subrata Ghosh, Dorota Moszczyńska, Carlo S Casari, Agnieszka Maria Jastrzębska","doi":"10.1039/d5nh00280j","DOIUrl":"https://doi.org/10.1039/d5nh00280j","url":null,"abstract":"The rapid advancement of nanomaterial-based thin-film processing has significantly contributed to the development of multifunctional optoelectronic devices. Among novel nanomaterials, MXenes, 2D transition metal carbides, nitrides, and carbonitrides have garnered substantial attention due to their high optical transparency, tunable optical properties, and excellent electrochemical performance. In particular, niobium carbide (Nb2CTx) MXene holds great promise for photoelectrochemical photodetectors (PEC PDs) due to its narrow-band photodetection capability, solution-processing, and stability under light irradiation. However, current Nb2CTx-based and 2D-based PEC PDs, in general, suffer from low photocurrent density, limited optical transparency, and poor environmental stability, hindering their practical applications. In this study, we developed a polymeric binder-free transparent reduced Nb2CTx/graphene oxide (r-Nb2CTx/GO) heterostructured thin film using a facile layer-by-layer technique. Incorporating reduced GO not only assists in improving the electrical conductivity of the heterostructure but also serves as a binder for MXene flakes. We systematically investigate the physicochemical properties of the film, its photodetection, and electrochemical performance. The optimized film exhibits outstanding transparency (70% at 550 nm), narrow-band photodetection response in the ultraviolet region, an excellent photoresponsivity of 50.21 μA W-1, and high environmental stability. Altogether, this study paves the way for developing Nb2CTx-based heterostructures for highly sensitive and environmentally stable transparent PEC PDs.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-voltage hydrovoltaic generator based on micro/nano multi-scale superhydrophilic SiO₂@activated carbon with enhanced capillary infiltration performance. 基于微纳多尺度超亲水性SiO2@activated碳的高压光伏发电机，具有增强的毛细管渗透性能。

IF 12.2 2区材料科学

Materials Horizons Pub Date : 2025-07-25 DOI: 10.1039/d5mh01101a

Luomin Wang, Weifeng Zhang, Yuan Deng

{"title":"High-voltage hydrovoltaic generator based on micro/nano multi-scale superhydrophilic SiO2@activated carbon with enhanced capillary infiltration performance.","authors":"Luomin Wang, Weifeng Zhang, Yuan Deng","doi":"10.1039/d5mh01101a","DOIUrl":"https://doi.org/10.1039/d5mh01101a","url":null,"abstract":"At least 60 petawatts (1015 watts) of energy can be absorbed and released annually through the ubiquitous water cycle, but only a fraction of it is exploited. The prospect of harvesting energy from water evaporation and streaming has garnered increasing attention. Nevertheless, there still exist challenges, including insufficient liquid-solid interface contact and inadequate liquid transport. Herein, a synergistic composite material system comprising micron-scale activated carbon and nano-scale silicon dioxide particles via multistep ball milling processes is introduced. The superhydrophilic material combined with a hierarchical structure enhances capillary infiltration performance, thus ensuring continuous liquid flow and sustained transpiration. As a result, the hydrovoltaic generator achieves efficient energy harvesting (an open-circuit voltage of >4.3 V) and environmental monitoring (response to variations in sunlight intensity and wind speed). Notably, the device can maintain high voltage output for over one year, demonstrating its long-term stability. This study can provide guidelines for effectively harnessing sustainable green energy sources in the future.","PeriodicalId":87,"journal":{"name":"Materials Horizons","volume":" ","pages":""},"PeriodicalIF":12.2,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultralow energy consumption conjugated polymers with perovskite quantum dots via polarity adjustment for photosynaptic transistors. 钙钛矿量子点超低能耗共轭聚合物的极性调整光突触晶体管。

IF 12.2 2区材料科学

Materials Horizons Pub Date : 2025-07-25 DOI: 10.1039/d5mh00833f

Wei-Cheng Chen, Ya-Shuan Wu, Yan-Cheng Lin, Yu-Hang Huang, Jing-Yang Wu, Kai-Wei Lin, Cheng-Liang Liu, Chi-Ching Kuo, Wen-Chang Chen

{"title":"Ultralow energy consumption conjugated polymers with perovskite quantum dots via polarity adjustment for photosynaptic transistors.","authors":"Wei-Cheng Chen, Ya-Shuan Wu, Yan-Cheng Lin, Yu-Hang Huang, Jing-Yang Wu, Kai-Wei Lin, Cheng-Liang Liu, Chi-Ching Kuo, Wen-Chang Chen","doi":"10.1039/d5mh00833f","DOIUrl":"https://doi.org/10.1039/d5mh00833f","url":null,"abstract":"Heterojunction-based photosynaptic transistors have gained significant attention in neuromorphic electronics due to their ease of integration and optical communication capabilities. However, achieving efficient photogenerated carrier transfer within heterojunctions remains a critical challenge in devices utilizing organic and photosensitive materials. This study demonstrates that tuning the bipolarity of perovskite quantum dots (PeQDs) through Sn doping effectively modulates electron and hole trapping properties in conjugated polymer (CP)-PeQD nanocomposites, paving the way for energy-efficient neuromorphic electronics. Optimal Sn doping enhanced PeQDs' photoluminescence quantum yield and adjusted energy levels, promoting efficient electron trapping in p-type devices while reducing hole trapping in n-type systems. Integrating Sn-PeQDs with p-type CPs (diketopyrrolopyrrole-selenophene) enabled exceptional photosynaptic behaviors, such as short-term and long-term plasticity and spike-dependent plasticity. Remarkably, p-type CPs/Sn-PeQDs with optimal Sn doping achieved ultralow energy consumption of 0.169 aJ at a drain voltage of -0.1 mV with a 1 ms light pulse, significantly outperforming earlier p-type optoelectronic synapse designs. This work underscores the potential of Sn-PeQDs as a robust strategy for designing efficient, low-energy neuromorphic systems for next-generation electronics.","PeriodicalId":87,"journal":{"name":"Materials Horizons","volume":" ","pages":""},"PeriodicalIF":12.2,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision nanomaterials in colorectal cancer: advancing photodynamic and photothermal therapy 精密纳米材料在结直肠癌中的应用：推进光动力和光热治疗

IF 3.9 3区化学

RSC Advances Pub Date : 2025-07-25 DOI: 10.1039/D5RA03996G

Yuhan Chen and Dong Tang

{"title":"Precision nanomaterials in colorectal cancer: advancing photodynamic and photothermal therapy","authors":"Yuhan Chen and Dong Tang","doi":"10.1039/D5RA03996G","DOIUrl":"https://doi.org/10.1039/D5RA03996G","url":null,"abstract":"Nanomaterials, due to their unique size, excellent targeting ability, and good biocompatibility, have gradually gained attention in oncologic medical treatments. Photodynamic therapy (PDT) and photothermal therapy (PTT), known for their low side effects and minimal trauma, are widely used in immunotherapy for malignant tumors. However, limitations such as low light penetration depth, poor targeting, and localized thermal effects restrict the application scope of photothermal dynamic therapy. Clinical studies have found that nano-mediated targeted drug carriers exhibit low toxicity and good biocompatibility. Furthermore, the superior photothermal conversion performance of nanomaterials can significantly enhance the efficacy of photothermal dynamic therapy in colorectal cancer treatment. Nanomaterials, which have been involved in various cancer treatment processes, represent an emerging medical biomaterial. This review systematically explores the types of nanomaterials currently commonly applied in medicine, with a particular focus on their breakthroughs and cutting-edge research in photodynamic therapy (PDT) and photothermal therapy (PTT) for colorectal cancer. It also discusses the future prospects and improvement strategies of nanomaterials in precision medicine.","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 33","pages":" 26583-26600"},"PeriodicalIF":3.9,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra03996g?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144695677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0