The Royal Society of Chemistry最新文献

{"title":"MnO₂-coated necklace-like CoFe@carbon nanofiber composites for superior electromagnetic wave absorption.","authors":"Yiliang Liu, Ying Lin, Zhixin Cai, Yongzhen Ma, Hongwei Zhou, Wei Chai, Qibin Yuan, Haibo Yang","doi":"10.1039/d4mh01783h","DOIUrl":"https://doi.org/10.1039/d4mh01783h","url":null,"abstract":"<p><p>With the rapid development of modern electronic technology, electromagnetic wave (EMW) absorption materials play a crucial role in solving the problem of electromagnetic radiation pollution. By designing unique microstructures or composite magnetic components, the EMW attenuation ability of carbon nanofibers (CNFs) can be enhanced. However, the ultra-high conductivity of CNFs leads to impedance mismatch, necessitating the introduction of components that can rapidly optimize dielectric properties for improved impedance matching. In this study, Co_0.7Fe_0.3@CNFs@MnO₂ (CFCM) was fabricated by coating MnO₂ nanosheets on necklace-like CoFe@carbon nanofiber composites. The coated MnO₂ nanosheets not only enhance the EMW attenuation ability, but also improve impedance matching. The results indicate that the minimum reflection loss of the sample is -62.7 dB, and the effective absorption bandwidth reaches 6.5 GHz. This work presents a valuable method to prepare outstanding EMW absorption materials with a necklace-like 3D network hierarchical structure.</p>","PeriodicalId":87,"journal":{"name":"Materials Horizons","volume":" ","pages":""},"PeriodicalIF":12.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143770768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction: Yttrium- and zirconium-decorated Mg12O12–X (X = Y, Zr) nanoclusters as sensors for diazomethane (CH2N2) gas","authors":"Terkumbur E. Gber, Hitler Louis, Obinna C. Ngana, Ismail O. Amodu, Ernest E. Ekereke, Innocent Benjamin, Stephen A. Adalikwu and Adedapo Adeyinka","doi":"10.1039/D5RA90038G","DOIUrl":"https://doi.org/10.1039/D5RA90038G","url":null,"abstract":"<p >Retraction of ‘Yttrium- and zirconium-decorated Mg<small>₁₂</small>O<small>₁₂</small>–X (X = Y, Zr) nanoclusters as sensors for diazomethane (CH<small>₂</small>N<small>₂</small>) gas’ by Terkumbur E. Gber <em>et al.</em>, <em>RSC Adv.</em>, 2023, <strong>13</strong>, 25391–25407, https://doi.org/10.1039/D3RA02939E.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 13","pages":" 10336-10336"},"PeriodicalIF":3.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra90038g?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical properties of <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i> dual-species biofilms grown in chronic wound-based models.","authors":"Bikash Bhattarai, Gordon F Christopher","doi":"10.1039/d4sm01441c","DOIUrl":"https://doi.org/10.1039/d4sm01441c","url":null,"abstract":"<p><p>Wound infections become chronic due to biofilm formation by pathogenic bacteria; two such pathogens are <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i>. These bacteria are known to form polymicrobial biofilms in wounds, which exhibit increased colonization rates, enhanced chronicity, and greater resistance to treatment. Previously, the impacts of a wound bed environment on the mechanical properties of <i>P. aeruginosa</i> biofilms have been explored, and in this work the role of a wound bed environment in the viscoelasticity and microstructure of polymicrobial biofilms is characterized. We hypothesize that common wound bed proteins mediate interactions between <i>S. aureus</i> and <i>P. aeruginosa</i> to enable the formation of more elastic and stiff biofilms. Growth media with varying protein content as well as additional collagen, a protein associated with a wound extracellular matrix, were utilized to test our hypothesis. Microrheology indicates that both <i>P. aeruginosa</i> and <i>S. aureus</i> form relatively stiffer single-species biofilms in a wound environment with collagen. <i>S. aureus</i> produced stiffer biofilms in the presence of collagen, regardless of other wound proteins, likely due to its interactions with collagen. When both species were grown together in wound-like media, synergistic effects led to stiffer dual-species biofilms compared to their single-species forms. Under all growth conditions, collagen significantly contributed to stiffening <i>P. aeruginosa</i>/<i>S. aureus</i> dual-species biofilms, suggesting that it mediates complex interspecies interactions. High-resolution imaging and analysis revealed that collagen also influenced the microstructures of <i>P. aeruginosa</i>/<i>S. aureus</i> dual-species biofilms. In media containing wound proteins and collagen, <i>S. aureus</i> clusters were larger and exhibited more complex shapes. These results indicate that the wound bed environment not only provides improved antibacterial resistance due to cooperative interactions, but also improved mechanical protection, which impact common treatment methods like debridement.</p>","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143770706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IRF4 as a molecular biomarker in pan-cancer through multiple omics integrative analysis.","authors":"Yiqing Tan, Yiping Yang, Mingjun Zhang, Ni Li, Lei Hu, Mingyou Deng, Yin Xiao, Yingying Wang, Fuhua Tian, Ran Sun","doi":"10.1039/d4ay02269f","DOIUrl":"https://doi.org/10.1039/d4ay02269f","url":null,"abstract":"<p><p>IRF4, characterized by its unique helix-turn-helix DNA-binding motif, is a member of the interferon regulatory factor (IRF) family. It plays a critical role in regulating host defense mechanisms, including innate and adaptive immune responses, as well as oncogenesis. However, the precise role of IRF4 in malignant tumors remains poorly understood. In this study, we first investigated IRF4 gene expression across various cancer types and its distribution within different molecular and immunological subtypes, providing a comprehensive understanding of its expression patterns in pan-cancer. We further explored the interacting proteins, diagnostic significance, molecular characteristics, prognostic relevance, and biological functions of IRF4 in diverse cancers. Focusing on colorectal cancer (CRC), we conducted a detailed analysis of IRF4, examining its associations with clinical features and outcomes across multiple clinical subgroups and databases. Additionally, we assessed IRF4 expression at both transcriptional and translational levels in CRC tumor specimens using tissue microarrays. Our findings revealed that IRF4 expression varies significantly not only across cancer types but also among molecular and immunological subtypes. In CRC, elevated IRF4 expression was associated with poorer overall survival. Notably, IRF4 was predominantly expressed in immune cells and showed a strong correlation with tumor immune regulation. Given its high predictive accuracy for cancer outcomes and robust prognostic associations, IRF4 may serve as a valuable prognostic biomarker for CRC. In conclusion, IRF4 represents a unique molecular biomarker for pan-cancer prognosis and an independent prognostic risk factor for CRC. Its critical role in immune regulation also positions IRF4 as a promising target for immunotherapeutic strategies in CRC.</p>","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143770757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High throughput drug screening platform utilizing capillary and artery cell layered models based on tumor-vascular cell interactions.","authors":"Jihyeon Song, Yeji Lee, Min-Seok Kim, Giheon Ha, WonJun Jang, Ulziituya Batjargal, Younggyun Kim, Han-Jun Kim, Junmin Lee","doi":"10.1039/d4lc00950a","DOIUrl":"https://doi.org/10.1039/d4lc00950a","url":null,"abstract":"<p><p>Interactions between tumors and adjacent blood vessels are critical in the tumor microenvironment (TME) for influencing angiogenesis and hematogenous metastasis. Understanding these interactions within the native TME is vital for targeting various tumors, including brain tumors, due to the complexities of the blood-brain barrier. Developing an accurate tumor model that includes cell-cell and cell-matrix interactions, as well as blood flow-induced shear stress, is essential for high-throughput screening (HTS) of anti-cancer drugs. Here, we developed a glioblastoma (GBM) model surrounded by vascular cells. The arterial model was constructed by encapsulating GBM spheroids with layers of human smooth muscle cells (SMCs) and human umbilical vein endothelial cells (HUVECs), while the capillary cell layered model used only HUVECs. Comparative analysis with tumors from different organs revealed the significant role for platelet endothelial cell adhesion molecule (PECAM) in GBM-blood vascular cell interactions. Cytokine secretion analysis demonstrated PECAM's impact on tumor-specific angiogenic potential. Testing with anti-cancer drugs revealed increased expression of PECAM-associated proteins, drug resistance cytokines, and genes associated with tumor progression and metastasis. Additionally, we developed a HTS platform by encapsulating these tumor models in hydrogels and subjecting them to media circulation, effectively mimicking the dynamic TME, suitable for cancer treatment research and drug development.</p>","PeriodicalId":85,"journal":{"name":"Lab on a Chip","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143770764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual organic structure-directing agents in zeolite synthesis: cooperation or competition?","authors":"Amirhossein Javdani, Juna Bae, Gleb Ivanushkin, Michiel Dusselier","doi":"10.1039/d5mh00235d","DOIUrl":"https://doi.org/10.1039/d5mh00235d","url":null,"abstract":"<p><p>Organic structure-directing agents (OSDAs) play a vital role in the structural arrangement and compositional diversity of zeolites. The synthesis procedure and properties of zeolites can be improved through the \"dual-OSDA\" approach, which involves cooperation and/or competition of different OSDAs in the synthesis media. Two OSDAs achieving results that neither of the OSDAs can deliver on its own is referred to as the \"cooperative OSDA\" approach. In this manner, one can enhance zeolite properties by stabilizing different parts of the framework and altering the synthesis outcome, such as acidity and/or Al distribution. However, cooperation can easily be disrupted, and one of the challenges in dual-OSDA zeolite synthesis is determining the conditions under which OSDA molecules can function in harmony to affect zeolite properties and control phase selection. On the other hand, competition does not always result in negative outcomes (<i>e.g.</i>, intergrowth materials). In this review, we discussed the importance of cooperative dual-OSDA synthesis in certain cases, explained the outcomes of this approach, and described the different behaviors key to cooperative systems.</p>","PeriodicalId":87,"journal":{"name":"Materials Horizons","volume":" ","pages":""},"PeriodicalIF":12.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143770766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A tailored 4G s-triazine-based dendrimer vehicle for quercetin endowed with MMP-2/9 inhibition and VEGF downregulation for targeting breast cancer progression and liver metastasis†","authors":"Doaa R. Ramadan, Heba A. Osman, Somaya Aly Madhy, Mohamed Teleb, A. I. Darwish, Marwa M. Abu-Serie, Nesreen S. Haiba, Sherine N. Khattab and Hosam H. Khalil","doi":"10.1039/D5RA01588J","DOIUrl":"https://doi.org/10.1039/D5RA01588J","url":null,"abstract":"<p >Motivated by our recent research progress on the exploitation of <em>s</em>-triazine dendritic platforms as bioactive carriers for well-known anticancer agents and/or targeting ligands, we set out to synthesize new rationally designed dendrimers endowed with MMP-2/9 inhibition potential for halting both breast and liver cancer progression with reduced off-target side effects. New three and four generation <em>s</em>-triazine based dendrimers were developed to incorporate potential ZBGs (Zinc Binding Groups) and carboxyl terminal groups to facilitate direct conjugation of anti-cancer drugs (quercetin) and/or targeting ligands (lactobionic acid) through a biodegradable ester bond. Compared to free quercetin (QUR), MTT assay revealed that all the quercetin-coupled dendrimers displayed better anticancer potential (IC<small>₅₀</small> = 12.690–29.316, 4.137–29.090 μM) against MCF-7 and HepG-2 cancer cells, respectively within their safe doses (EC<small>₁₀₀</small> = 134.35–78.44 μM). Conjugation of lactobionic acid and PEG boosted the anticancer potency against both treated cells, improved apoptosis and down regulated MMP-9 and VEGF gene expression levels in both treated cancer cells. Generally, the more branched <strong>G4</strong> dendrimer conjugates exhibited a superior overall anticancer performance compared to their respective <strong>G3</strong> analogues, except for their MMP-9 inhibition where <strong>G3</strong> conjugate appeared to be more potent and more selective than its <strong>G4</strong> analogue.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 13","pages":" 10426-10441"},"PeriodicalIF":3.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra01588j?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143769592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micellar media effect on the ultrasensitive quantitation of a diuretic medication at nano-scale levels with environmentally benign impact.","authors":"Samah Abo El Abass, Manal A Alossaimi, Abdulmalik S A Altamimi, Asmaa Kamal El-Deen","doi":"10.1039/d5ay00015g","DOIUrl":"https://doi.org/10.1039/d5ay00015g","url":null,"abstract":"<p><p>A novel micelle-augmented spectrofluorimetric method is proposed for the ultrasensitive estimation of bumetanide (BUM) at nanoscale concentrations. The method utilizes the unique properties of micelles to enhance the fluorescence intensity of BUM and measures its native fluorescence at 415 nm after excitation at 267 nm. The proposed method was optimized by evaluating the effect of organized media, buffer pH, and diluting solvent. The method validity was further assessed following the ICH guidelines, where excellent linearity was obtained over a concentration range of 40.0-400.0 ng mL^-1, with a correlation coefficient of 0.9999 and a low limit of detection (LOD) of 5.31 ng mL^-1. The method was further applied for the determination of BUM in different dosage forms with % recoveries greater than 98%, as well as for content uniformity testing. Ultimately, a comprehensive assessment of the method's environmental impact was performed using different metrics, highlighting the eco-friendly nature of the method and underlining its potential for sustainable analytical practices in pharmaceutical research and beyond.</p>","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143770758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Luminescent down-shifting layers based on an isoquinoline-Eu(iii) complex for enhanced efficiency of c-Si solar cells under extreme UV radiation conditions†","authors":"Darío Espinoza, Ronald Nelson, Fabian Vargas, Alifhers Mestra, Laura Sánchez-Muñoz, Pere Alemany, Douglas Olivares, Luis Conde and Jaime Llanos","doi":"10.1039/D5RA00584A","DOIUrl":"https://doi.org/10.1039/D5RA00584A","url":null,"abstract":"<p >The Atacama Desert's extreme UV radiation impacts photovoltaic devices, reducing silicon solar cell efficiency through overheating and photodegradation. To address this, we integrated a europium complex derived from 1-(diphenylphosphoryl)-3-isoquinolinecarboxylic acid into a polyvinyl butyral (PVB) matrix, forming a luminescent down-shifting layer (LDSL) that converts UV radiation into visible light. This LDSL improves light harvesting and mitigates UV-induced degradation. After LDSL application, photovoltaic analysis of a c-Si cell showed significant enhancements: short-circuit current density (<em>J</em><small>_sc</small>) increased from 28.82 to 34.69 mA cm<small>⁻²</small>, open-circuit voltage (<em>V</em><small>_oc</small>) rose from 630.6 to 635.7 mV, and the fill factor (FF) remained stable. Incident photon-to-current efficiency (IPCE) curves indicated better performance, particularly in the UVA range, with overall cell efficiency improving from 14.10% to 16.62% at higher Eu complex concentrations. Electrochemical impedance spectroscopy (EIS) revealed that the Eu complex improved charge transfer, reducing recombination losses. This approach demonstrates significant potential for enhancing solar cell performance in high-irradiance environments like the Atacama Desert.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 13","pages":" 10257-10264"},"PeriodicalIF":3.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra00584a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From synthesis to properties: expanding the horizons of machine learning in nanomaterials research.","authors":"Shanhui Diao, Qiong Wu, Shimei Li, Guochen Xu, Xiangling Ren, Longfei Tan, Guihua Jiang, Peng Song, Xianwei Meng","doi":"10.1039/d4mh01909a","DOIUrl":"https://doi.org/10.1039/d4mh01909a","url":null,"abstract":"<p><p>Nanotechnology involves the manipulation of matter at dimensions ranging from 1 to 100 nanometers. Prediction of synthesis parameters, structure, properties and applications is a cascade process in nanomaterials research, each of these stages being interconnected and having a correlative influence on one another. Traditionally, the \"trial and error\" approach in nanomaterial research has several limitations, including time-consuming, laborious and resource-intensive. With the rise and vigorous development of artificial intelligence technology as the fourth paradigm of materials research, machine learning offers a significant research prospect for the accelerated new materials design, synthesis optimization and property prediction. In this review, the three key elements of machine learning including data, descriptors and machine learning methods for nanomaterial research are discussed. An overview of the applications of machine learning in nanomaterial research is provided, particularly focusing on various synthesis methods of single nanomaterials and property prediction of nanocomposites, through the framework of synthesis-structure-property-application relationships. Finally, the potential of this fast-growing field is highlighted, as well as the formidable challenges it faces.</p>","PeriodicalId":87,"journal":{"name":"Materials Horizons","volume":" ","pages":""},"PeriodicalIF":12.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143770767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}