The Royal Society of Chemistry最新文献_第4页

Synthesis of 1,4-benzodioxepines via electrochemical oxyselenenylation of 2-O-tethered alkenyl phenylmethanol and diselenides. 通过电化学氧化 2-O 系烯基苯基甲醇和二硒化物合成 1,4-苯并二氧杂环庚烷。

IF 2.9 3区化学

Organic & Biomolecular Chemistry Pub Date : 2024-11-27 DOI: 10.1039/d4ob01483a

Junsheng Hou, Bingxin You, Ruiqi Lv, Xinxin Zhang, Jinyang Shen, Jiaojiao Li, Xi Zuo, Qiang Liu

引用次数: 0

Tetraarylammonium salts - synthesis, properties and emerging use. 四芳基铵盐--合成、特性和新兴用途。

IF 2.9 3区化学

Organic & Biomolecular Chemistry Pub Date : 2024-11-27 DOI: 10.1039/d4ob01386g

Alexander Marriott, Götz Bucher

引用次数: 0

Zn²⁺ ions improve the fidelity of metal-mediated primer extension while suppressing intrinsic and Mn²⁺-induced mutagenic effects by DNA polymerases. Zn2+ 离子提高了金属介导的引物延伸的保真度，同时抑制了 DNA 聚合酶的内在诱变效应和 Mn2+ 诱导的诱变效应。

IF 2.9 3区化学

Organic & Biomolecular Chemistry Pub Date : 2024-11-27 DOI: 10.1039/d4ob01433b

Tatsuya Funai, Natsumi Tanaka, Riyo Sugimachi, Shun-Ichi Wada, Hidehito Urata

{"title":"Zn2+ ions improve the fidelity of metal-mediated primer extension while suppressing intrinsic and Mn2+-induced mutagenic effects by DNA polymerases.","authors":"Tatsuya Funai, Natsumi Tanaka, Riyo Sugimachi, Shun-Ichi Wada, Hidehito Urata","doi":"10.1039/d4ob01433b","DOIUrl":"10.1039/d4ob01433b","url":null,"abstract":"While Mn2+ ions are well-established for reducing the fidelity of DNA polymerases, leading to the misincorporation of nucleotides, our investigation of the effects of metal ions revealed a contrasting role of Zn2+. Here, we demonstrate that Zn2+ ions enhance the fidelity of DNA polymerases (the 3' → 5' exonuclease-deficient Klenow fragment and Taq DNA polymerase) by suppressing misincorporation during primer extension reactions. Remarkably, Zn2+ ions inhibit both intrinsic misincorporation and Mn2+-induced misincorporation of nucleotides. Furthermore, Zn2+ ions also effectively suppressed misincorporation during metal-mediated primer extension reactions, which involved forming Ag+ and Hg2+ ion-mediated base pairs. These findings suggest that Zn2+ ions inhibit both intrinsic and Mn2+-induced mismatched base pair formation. Consequently, the combined use of Mn2+ and Zn2+ ions may offer a strategy for precisely regulating the fidelity of DNA polymerases. Remarkably, Zn2+ ions even suppress misincorporation in primer extension reactions that rely on metal-mediated base pairs, and conversely, this suggests that DNA polymerases recognize metal-mediated base pairs such as T-Hg2+-T, C-Ag+-A, and C-Ag+-T as relatively stable base pairs. These results imply that Zn2+ ions may also enhance the fidelity of DNA polymerases when incorporating non-canonical nucleobases, potentially paving the way for the expansion of the genetic alphabet.","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":"9094-9100"},"PeriodicalIF":2.9,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142491291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iridium-catalyzed tandem olefination/aza-Michael reaction: rapid access to N-N functionalized hydrazides. 铱催化的串联烯化/aza-迈克尔反应：快速获得 N-N 官能化肼。

IF 2.9 3区化学

Organic & Biomolecular Chemistry Pub Date : 2024-11-27 DOI: 10.1039/d4ob01631a

Chao Zhang, Lin Dong

引用次数: 0

BF₃·OEt₂-catalyzed/mediated alkyne cyclization: a comprehensive review of heterocycle synthesis with mechanistic insights. BF3-OEt2 催化/介导的炔环化：杂环合成的全面回顾与机理启示。

IF 2.9 3区化学

Organic & Biomolecular Chemistry Pub Date : 2024-11-27 DOI: 10.1039/d4ob01426j

Priya Ghosh, Anil K Saikia

引用次数: 0

Hydrogel-based 3D fabrication of multiple replicas with varying sizes and materials from a single template via iterative shrinking. 基于水凝胶的三维制造技术，通过迭代收缩，从单一模板中制造出多个不同尺寸和材料的复制品。

IF 2.9 3区化学

Soft Matter Pub Date : 2024-11-27 DOI: 10.1039/d4sm00835a

Eunseok Heo, Hye Been Koo, Jun Chang Yang, In Cho, Hyun-Hee Lee, Yong-Jin Yoon, Steve Park, Jae-Byum Chang

{"title":"Hydrogel-based 3D fabrication of multiple replicas with varying sizes and materials from a single template via iterative shrinking.","authors":"Eunseok Heo, Hye Been Koo, Jun Chang Yang, In Cho, Hyun-Hee Lee, Yong-Jin Yoon, Steve Park, Jae-Byum Chang","doi":"10.1039/d4sm00835a","DOIUrl":"10.1039/d4sm00835a","url":null,"abstract":"3D printing technologies have been widely used for the rapid prototyping of 3D structures, but their application in a broader context has been hampered by their low printing throughput. For the same structures to be produced in a variety of sizes and materials, each must be printed separately, which increases time and cost. Replicating 3D-printed structures in a variety of sizes using a molding process with size-tunable molds could be a solution, but it has only been applied to simple structures, such as those with tapered or vertical profiles. This work demonstrates the generation of multiple replicas of varying sizes and materials from a single 3D-printed template with complex geometries by using molds made of stretchable hydrogel that shrink isotropically. We optimize hydrogel compositions to synthesize a hydrogel that is highly stretchable and shrinks isotropically in all directions. The high stretchability of this hydrogel allows for the removal of complex 3D-printed templates from hydrogel molds. The cavities of the hydrogel molds are then filled with polycaprolactone (PCL) and dried at 80 °C. As the hydrogel shrinks due to drying, the melted PCL fragments completely fill the cavities. The entire process can be repeated to produce multiple replicas in a variety of sizes and materials. Replicas that are one-tenth of the size of the original printed template can be produced. Finally, we demonstrate how our method can be used to reduce the size of interconnected geometries, which would be impossible to achieve using traditional molding processes.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":"9249-9260"},"PeriodicalIF":2.9,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chiral iodine-catalyzed asymmetric oxyamination of unactivated olefins. 手性碘催化未活化烯烃的不对称氧合反应。

IF 2.9 3区化学

Organic & Biomolecular Chemistry Pub Date : 2024-11-27 DOI: 10.1039/d4ob01575d

Gui-Ping Han, Jia-Qi Wang, Jing-Feng Zhao, Dao-Yong Zhu, Lu-Wen Zhang, Wei He

引用次数: 0

Terpolymerization reactions of epoxides, CO₂, and the third monomers toward sustainable CO₂-based polymers with controllable chemical and physical properties. 环氧化物、二氧化碳和第三种单体的三元共聚反应，实现具有可控化学和物理特性的可持续二氧化碳基聚合物。

IF 4.3 2区化学

Chemical Communications Pub Date : 2024-11-27 DOI: 10.1039/d4cc04615c

Koichi Nakaoka, Tadashi Ema

{"title":"Terpolymerization reactions of epoxides, CO2, and the third monomers toward sustainable CO2-based polymers with controllable chemical and physical properties.","authors":"Koichi Nakaoka, Tadashi Ema","doi":"10.1039/d4cc04615c","DOIUrl":"https://doi.org/10.1039/d4cc04615c","url":null,"abstract":"Carbon dioxide (CO2) serves as a cheap, abundant, and renewable C1 building block for the synthesis of organic compounds and polymers. Selective and efficient CO2 fixation processes are still challenging because of the kinetic and thermodynamic stability of CO2. Among various CO2 fixation processes, the ring-opening copolymerization (ROCOP) of epoxides and CO2 gives aliphatic polycarbonates with high atom economy, although the chemical and physical properties of the resulting polycarbonates are not necessarily satisfactory. Introducing the third monomers into this ROCOP system provides new terpolymers, and the thermal, optical, mechanical or degradation properties can be added or tuned by incorporating new polymer backbones derived from the third monomers at the expense of the CO2 content. Here we review the terpolymerization reactions of epoxides, CO2, and the third monomers such as cyclic anhydrides, lactones, lactides, heteroallenes, and olefins. The development of catalysts and the control of the polymer structures are described together with the chemical and physical properties of the resulting polymers.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142724299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analyses of mitochondrial metabolism in diseases: a review on 13C magnetic resonance tracers 分析疾病中的线粒体代谢：13C 磁共振示踪剂综述

IF 3.9 3区化学

RSC Advances Pub Date : 2024-11-27 DOI: 10.1039/D4RA03605K

Gaurav Sharma, Sergio Duarte, Qingyang Shen and Chalermchai Khemtong

{"title":"Analyses of mitochondrial metabolism in diseases: a review on 13C magnetic resonance tracers","authors":"Gaurav Sharma, Sergio Duarte, Qingyang Shen and Chalermchai Khemtong","doi":"10.1039/D4RA03605K","DOIUrl":"https://doi.org/10.1039/D4RA03605K","url":null,"abstract":"Metabolic diseases such as obesity, type 2 diabetes, and cardiovascular diseases have become a global health concern due to their widespread prevalence and profound impact on life expectancy, healthcare expenditures, and the overall economy. Devising effective treatment strategies and management plans for these diseases requires an in-depth understanding of the pathophysiology of the metabolic abnormalities associated with each disease. Mitochondrial dysfunction is intricately linked to a wide range of metabolic abnormalities and is considered an important biomarker for diseases. However, assessing mitochondrial functions in viable tissues remains a challenging task, with measurements of oxygen consumption rate (OCR) and ATP production being the most widely accepted approaches for evaluating the health of mitochondria in tissues. Measurements of cellular metabolism using carbon-13 (or 13C) tracers have emerged as a viable method for characterizing mitochondrial metabolism in a variety of organelles ranging from cultured cells to humans. Information on metabolic activities and mitochondrial functions can be obtained from magnetic resonance (MR) analyses of 13C-labeled metabolites in tissues and organs of interest. Combining novel 13C tracer technologies with advanced analytical and imaging tools in nuclear magnetic resonance spectroscopy (NMR) and magnetic resonance imaging (MRI) offers the potential to detect metabolic abnormalities associated with mitochondrial dysfunction. These capabilities would enable accurate diagnosis of various metabolic diseases and facilitate the assessment of responses to therapeutic interventions, hence improving patient health and optimizing clinical outcomes.","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 51","pages":" 37871-37885"},"PeriodicalIF":3.9,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/ra/d4ra03605k?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142714122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication and characterization of xanthan gum nanofibers reinforced with thiosemicarbazide: adsorption of Pb2+ from an aqueous medium† 硫代氨基脲增强黄原胶纳米纤维的制备与表征：水介质中 Pb2+ 的吸附†.

IF 3.9 3区化学

RSC Advances Pub Date : 2024-11-27 DOI: 10.1039/D4RA06364C

Reem Ghubayra, Ibtisam Mousa, Marwah M. M. Madkhali, Abdel-Nasser M. A. Alaghaz and Asaad F. Hassan

{"title":"Fabrication and characterization of xanthan gum nanofibers reinforced with thiosemicarbazide: adsorption of Pb2+ from an aqueous medium†","authors":"Reem Ghubayra, Ibtisam Mousa, Marwah M. M. Madkhali, Abdel-Nasser M. A. Alaghaz and Asaad F. Hassan","doi":"10.1039/D4RA06364C","DOIUrl":"https://doi.org/10.1039/D4RA06364C","url":null,"abstract":"In this study, electrospinning was used to fabricate xanthan gum (XF) and thiosemicarbazide/xanthan gum (TXF) nanofibers crosslinked with ferric ions for effective Pb2+ adsorption. The produced nanofibers were investigated using several physicochemical methods. Both XF and TXF demonstrated thermal stability up to 800 °C, with mass losses of 79% and 75%, respectively. TXF had a surface area of 153.4 m2 g−1 and point of zero charge at pH 6.7. ATR-FTIR analysis revealed the existence of surface chemical functional groups such as –NH2, –NH, and –C<img>S owing to thiosemicarbazide reinforcement. XF and TXF displayed maximum adsorption capacities of 211.65 and 289.18 mg g−1 at pH 6, 2.0 g L−1 nanofiber dose, 22 °C, and after 40 min of contact shaking time. The adsorption process was investigated using several nonlinear adsorption models as well as by desorption and reusability investigations. Thermodynamics examination demonstrated the spontaneous, endothermic physisorption of Pb2+ onto XF and TXF. Ethylenediaminetetraacetic acid was selected as the most efficient eluent for Pb2+ removal from the nanofiber surfaces, with desorption efficiencies of 100% and 97% for XF and TXF, respectively. TXF and XF revealed remarkable sustainability, with reductions in adsorption capacities of only 7% and 12% of the initial removal efficiency after 10 cycles of adsorption/desorption, respectively. As a solid adsorbent for the removal of heavy metal cations, the produced TXF nanofiber demonstrated great sustainability and environmental friendliness.","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 51","pages":" 37859-37870"},"PeriodicalIF":3.9,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/ra/d4ra06364c?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142714121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0