The Royal Society of Chemistry最新文献_第4页

Cytotoxicity-guided isolation of elatostemanosides I–VI from Elatostema tenuicaudatum W. T. Wang and their cytotoxic activities†

IF 3.9 3区化学

RSC Advances Pub Date : 2025-04-04 DOI: 10.1039/D4RA09007A

Quoc-Dung Tran Huynh, Thuy-Tien Thi Phan, Ta-Wei Liu, Truc-Ly Thi Duong, Su-Jung Hsu, Ching-Chuan Kuo, Man-Hsiu Chu, Yun-Han Wang, Thanh-Vu Nguyen, Yao-An Shen, Yu-Jui Fan, Dang-Khoa Nguyen, Thanh-Hoa Vo and Ching-Kuo Lee

{"title":"Cytotoxicity-guided isolation of elatostemanosides I–VI from Elatostema tenuicaudatum W. T. Wang and their cytotoxic activities†","authors":"Quoc-Dung Tran Huynh, Thuy-Tien Thi Phan, Ta-Wei Liu, Truc-Ly Thi Duong, Su-Jung Hsu, Ching-Chuan Kuo, Man-Hsiu Chu, Yun-Han Wang, Thanh-Vu Nguyen, Yao-An Shen, Yu-Jui Fan, Dang-Khoa Nguyen, Thanh-Hoa Vo and Ching-Kuo Lee","doi":"10.1039/D4RA09007A","DOIUrl":"https://doi.org/10.1039/D4RA09007A","url":null,"abstract":" Elatostema tenuicaudatum W. T. Wang, a medicinal plant traditionally utilized in herbal remedies, was explored for its cytotoxic properties. Bioassay-guided fractionation led to the discovery of six novel compounds, designated as elatostemanosides I–VI, with their structures elucidated through advanced spectroscopic methods and DP4+ analysis. Among these, compounds 2, 5, and 6 demonstrated moderate cytotoxicity against the human liver cancer cell line HepG2, exhibiting IC50 values of 18.2 ± 2.1, 32.1 ± 0.4, and 57.6 ± 1.3 µM, respectively. Notably, compound 6 also displayed significant activity against the human breast cancer cell line HCC1806, with an IC50 value of 35.4 ± 0.3 µM. Mechanistic studies revealed these compounds induced apoptosis by modulating the Bax/Bcl-2 ratio. Furthermore, structure–activity relationship (SAR) analysis underscored the importance of specific functional groups in mediating cytotoxic effects.","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 14","pages":" 10639-10652"},"PeriodicalIF":3.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d4ra09007a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143777991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction: Synthesis, characterization, and theoretical studies of the photovoltaic properties of novel reactive azonitrobenzaldehyde derivatives

IF 3.9 3区化学

RSC Advances Pub Date : 2025-04-04 DOI: 10.1039/D5RA90041G

Hitler Louis, Izubundu B. Onyebuenyi, Joseph O. Odey, Azuaga T. Igbalagh, MaryJane T. Mbonu, Ededet A. Eno, Anthony M. S. Pembere and Offiong E. Offiong

引用次数: 0

Bromate removal in water through electrochemical reduction using Magnéli phase titanium oxide electrode†

IF 3.9 3区化学

RSC Advances Pub Date : 2025-04-04 DOI: 10.1039/D5RA01013F

Lun Guo, David E. Williams, Lev Bromberg and Lokesh P. Padhye

{"title":"Bromate removal in water through electrochemical reduction using Magnéli phase titanium oxide electrode†","authors":"Lun Guo, David E. Williams, Lev Bromberg and Lokesh P. Padhye","doi":"10.1039/D5RA01013F","DOIUrl":"https://doi.org/10.1039/D5RA01013F","url":null,"abstract":"This study demonstrates the effective electrochemical degradation of bromate, achieving over 95% removal, using both sheet electrodes and reactive membranes fabricated from Magnéli phase titanium oxide (TinO2n−1, n = 4–10). Increasing the applied voltage and electrolyte concentration, as well as decreasing the pH, significantly enhanced bromate reduction efficiency. Experimental results suggest that both direct and indirect pathways contribute to the overall degradation process. The impact of coexisting ions was also evaluated. At 1 mM, their inhibitory effect was negligible, whereas, at 10 mM, the inhibition became pronounced in the order SO42− > CO32− > Cl− ≈ NO3− ≈ NO2− > ClO4−. When applied to secondary effluent wastewater, this electrochemical approach achieved 70% degradation of bromate within six hours. Moreover, the Magnéli phase titanium oxide electrodes exhibited excellent stability and reusability, highlighting their potential for real-world water and wastewater treatment applications.","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 14","pages":" 10501-10510"},"PeriodicalIF":3.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra01013f?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143769614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Five-membered heterocycles as promising platforms for molecular logic gate construction

IF 3.9 3区化学

RSC Advances Pub Date : 2025-04-04 DOI: 10.1039/D5RA00749F

Alexander Ciupa

引用次数: 0

Retraction: The iron group transition-metal (Fe, Ru, Os) coordination of Se-doped graphitic carbon (Se@g-C3N4) nanostructures for the smart therapeutic delivery of zidovudine (ZVD) as an antiretroviral drug: a theoretical calculation perspective

IF 3.9 3区化学

RSC Advances Pub Date : 2025-04-04 DOI: 10.1039/D5RA90039E

Favour A. Nelson, Hitler Louis, Innocent Benjamin and Rawlings A. Timothy

引用次数: 0

Novel poly-deep eutectic solvent-functionalized magnetic graphene oxide nanomaterials for high-performance solid-phase extraction of trypsin.

IF 2.7 3区化学

Analytical Methods Pub Date : 2025-04-04 DOI: 10.1039/d5ay00252d

Jing Chen, Xiyan He, Yuzhi Wang

{"title":"Novel poly-deep eutectic solvent-functionalized magnetic graphene oxide nanomaterials for high-performance solid-phase extraction of trypsin.","authors":"Jing Chen, Xiyan He, Yuzhi Wang","doi":"10.1039/d5ay00252d","DOIUrl":"https://doi.org/10.1039/d5ay00252d","url":null,"abstract":"Three novel polymethacrylic acid-based deep eutectic solvent (DES)-functionalized magnetic graphene oxide composites were designed and successfully synthesized via the radical polymerization method. The aim was to achieve the selective solid-phase extraction of trypsin (Tryp). Among them, the magnetic extractant (MGO@PDES2) functionalized with a poly-deep eutectic solvent composed of tetraethylammonium chloride and methylpropionic acid at a molar ratio of 1 : 2 exhibited the highest extraction efficiency for Tryp. Owing to the high specific surface area of MGO and the abundant carboxyl functional groups in PDES2, the prepared MGO@PDES2 exhibited excellent selectivity and stability for Tryp extraction. Under optimal conditions, the extraction capacity of Tryp by MGO@PDES2 reached 708.85 mg g-1. The extraction driving forces between MGO@PDES2 and Tryp were hydrogen-bonding interactions and electrostatic interactions. Among the seven biomacromolecules, MGO@PDES2 displayed outstanding selectivity for Tryp. In addition, the results of cycling experiments indicated that MGO@PDES2 could be reused many times without a significant change in extraction capacity. Moreover, the proposed method was successfully applied to extract Tryp from the crude extract of bovine pancreas, yielding satisfactory results. All the results suggest that MGO@PDES2 is a promising magnetic extractant, which is expected to provide new ideas for the extraction and separation of proteins.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microfiber suspensions for the removal of adhered colloids from surfaces, microdevices, and cavities.

IF 2.9 3区化学

Soft Matter Pub Date : 2025-04-04 DOI: 10.1039/d5sm00065c

Marcel M Louis, Samantha A McBride, Janine K Nunes, Antonio Perazzo, Christopher A Kuchar, Mohamed E Labib, Howard A Stone

{"title":"Microfiber suspensions for the removal of adhered colloids from surfaces, microdevices, and cavities.","authors":"Marcel M Louis, Samantha A McBride, Janine K Nunes, Antonio Perazzo, Christopher A Kuchar, Mohamed E Labib, Howard A Stone","doi":"10.1039/d5sm00065c","DOIUrl":"https://doi.org/10.1039/d5sm00065c","url":null,"abstract":"Effective methods for cleaning surfaces are important for applications including dentistry, healthcare, micro-devices, and the manufacturing of electronic components and semiconductors. For example, surgical and dental instruments are susceptible to accumulation of aggregates and biofilm formation, which can lead to cross-contamination when ineffectively cleaned and reused. Complex fluids such as micro-fibrillated cellulose (MFC) can greatly assist in mechanically cleaning surfaces by removing strongly adhered aggregates without abrading the underlying material. We demonstrate that the heterogeneous structure of micro-fibrillated cellulose is effective in removing adhered particulates from surfaces and we characterize the cleaning efficiency of MFC suspensions in representative flow configurations. The experiments reported here involve flowing MFC solutions at various concentrations and at controlled shear rates through a rectangular microfluidic channel. Fluorescence microscopy is used to measure the removal of fluorescent particles that are adhered to the glass surface of the microfluidic device by electrostatic and surface forces. The particle removal with time is analyzed for each concentration of the MFC suspension and each shear rate to determine cleaning effectiveness. The rheology of the MFC solutions is also characterized and correlated to cleaning performance. We find that cleaning effectiveness increases with increasing fiber concentration and with increasing shear rate. Additionally, we compared the cleaning performance of the MFC suspensions with fluids that share similar rheological properties to highlight the role of shear thinning, elasticity, and tribology. Finally, we examine how sharp corners/edges within a microfluidic channel hinder cleaning and identify strategies for mitigating this hindrance.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fe-N-C oxidase-mimicking nanozymes for discrimination of antioxidants and detection of Hg².

IF 2.7 3区化学

Analytical Methods Pub Date : 2025-04-04 DOI: 10.1039/d5ay00313j

Shushu Chu, Mingyuan Xia, Peng Xu, Xueli Zhang, Wendong Liu, Yizhong Lu

{"title":"Fe-N-C oxidase-mimicking nanozymes for discrimination of antioxidants and detection of Hg2.","authors":"Shushu Chu, Mingyuan Xia, Peng Xu, Xueli Zhang, Wendong Liu, Yizhong Lu","doi":"10.1039/d5ay00313j","DOIUrl":"https://doi.org/10.1039/d5ay00313j","url":null,"abstract":"Single-atom nanozymes (SAzymes) with high atom utilization efficiency and well-defined coordination structures have been extensively studied. However, research on the use of the enzyme-like activity of SAzymes for the detection and discrimination of antioxidants remains relatively limited. Herein, synthesized Fe-N-C SAzymes (FeN4) display excellent oxidase-like activity with a maximum reaction rate of 1.083 × 10-7 M s-1, which is 40.85 times higher than that for NC nanozymes. Experimental studies and density functional theory (DFT) calculations revealed that the high catalytic performance arises from the efficient absorption and activation of O2 at highly exposed Fe sites. Based on the different inhibitory effects of ascorbic acid (AA), glutathione (GSH), and cysteine (Cys), a colorimetric sensor array for identifying antioxidants was developed. AA, GSH, and Cys were effectively distinguished through linear discriminant analysis (LDA). Moreover, a colorimetric platform for the rapid detection of trace Hg2+ was successfully presented, taking advantage of the strong binding ability between -SH of Cys and Hg2+, and achieving an impressive limit of detection (LOD) of 9.29 nM. This work not only provides a novel concept for distinguishing antioxidants but also expands the application of nanozymes in heavy metal ion detection.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of hydration, material properties, and pore structure of polymers enhanced with dendritic fibrous nanosilica as a concrete additive

IF 3.9 3区化学

RSC Advances Pub Date : 2025-04-03 DOI: 10.1039/D5RA00985E

Mohammad Azizi, Amin Honarbakhsh, Seyed Mojtaba Movahedifar, Mehdi Nobahari and Rahele Zhiani

{"title":"Analysis of hydration, material properties, and pore structure of polymers enhanced with dendritic fibrous nanosilica as a concrete additive","authors":"Mohammad Azizi, Amin Honarbakhsh, Seyed Mojtaba Movahedifar, Mehdi Nobahari and Rahele Zhiani","doi":"10.1039/D5RA00985E","DOIUrl":"https://doi.org/10.1039/D5RA00985E","url":null,"abstract":"Different cement-based grouting and repair materials have been created and are commonly employed in construction renovation projects. Nevertheless, conventional cement mortars face challenges like limited corrosion resistance and weak bonding strength. Polymers, commonly used as modifiers for repair mortars, provide enhanced mechanical properties, increased resistance to corrosion, and better bonding. Despite these advantages, many polymer modifiers are inherently limited in preventing crack initiation and propagation, while also increasing costs. This study incorporated different amounts of three types of polymers supported on dendritic fibrous nanosilica (DFNS-polymers) into cement mortar to evaluate their effects on mortar performance, pore structure, and cement hydration. The addition of DFNS-polymers significantly improved the durability and workability of the mortar. Moreover, the pore structure was optimized, resulting in a more balanced pore distribution and a reduction in pore and porosity size. This research introduces an effective approach to enhancing the performance of repair mortars by combining polymers with suitable fillers.","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 13","pages":" 10215-10226"},"PeriodicalIF":3.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra00985e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cluster-directed ionic framework supramolecular hydrogel with high-temperature tolerability and enhanced water evaporation.

IF 2.9 3区化学

Soft Matter Pub Date : 2025-04-03 DOI: 10.1039/d5sm00004a

Jiaxu Wang, Liang Yue, Mingfeng Wei, Bao Li, Lixin Wu

引用次数: 0