The Royal Society of Chemistry最新文献

{"title":"Soy isoflavones improve sympathetic nervous system-driven non-alcoholic fatty liver disease through estrogen-like effects.","authors":"Jing Yang, Yuhang Zhao, Zhengjie Ye, Zhiyi Liu, Lingling Chang, Xinran Wang, Yuandong Qiao, Liquan Tong, Yonggang Cao","doi":"10.1039/d5fo01459j","DOIUrl":"https://doi.org/10.1039/d5fo01459j","url":null,"abstract":"<p><p>This study investigated the advantages of gerbils as a sympathetic nervous system (SNS)-driven model for non-alcoholic fatty liver disease (NAFLD) and evaluated the therapeutic potential of soy isoflavones (SIFs). Gerbils exhibited unique SNS characteristics, with an adrenal gland-to-kidney weight ratio 2-3 times higher than that of C57BL/6 mice and Wistar rats, demonstrating elevated levels of adrenaline (AE) and noradrenaline (NE) as well as more pronounced anxiety-like behaviors, indicating enhanced SNS activity. Additionally, gerbils possessed liver lipid metabolism and storage capacities similar to humans, along with a simple genetic background, allowing them to more accurately reflect the pathogenesis of NAFLD. This study employed ELISA, marble-burying tests, Oil Red O staining, H&E staining, laser speckle contrast imaging, TUNEL staining, immunofluorescence, and qRT-PCR to systematically evaluate the NAFLD model in gerbils and investigate the therapeutic effects and underlying mechanisms of SIFs on NAFLD. The study found that SIFs could reduce hepatic fat deposition, improve liver function, and downregulate the expression levels of cGAS and STING in the liver by modulating the ER-cGAS-STING pathway, thereby suppressing inflammatory responses. These findings confirmed the suitability of gerbils as an ideal model for studying SNS-induced NAFLD and revealed the potential therapeutic value of SIFs in ameliorating NAFLD through specific signaling pathways. This research provided important insights for a deeper understanding of NAFLD pathogenesis and the development of novel treatment strategies.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visible-light-induced three-component alkylation of 1,3,4-oxadiazoles <i>via</i> 1,5-hydrogen atom transfer (1,5-HAT).","authors":"Zhongzhen Yang, Xingqin Tian, Yafei Zhu, Tianle Huang, Yong Wu, Guanghui Lv","doi":"10.1039/d5ob01243k","DOIUrl":"https://doi.org/10.1039/d5ob01243k","url":null,"abstract":"<p><p>Herein we first reported an attractive example of visible-light-induced three-component alkylation of 1,3,4-oxadiazoles <i>via</i> 1,5-hydrogen atom transfer. A broad range of 1,3,4-oxadiazoles, hydroxamic acid derivatives and alkenes were successfully transformed into the corresponding products in satisfactory yields. The reaction is characterized by mild reaction conditions, good functional group compatibility, broad substrate scope, and simple operation procedure.</p>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in the construction of quaternary pseudoanomeric centers in <i>gem-C</i>,<i>C</i>-glycosides: from zaragozic acids to remdesivir.","authors":"Damien Hazelard, Mathieu Pascaretti, Damien Tardieu, Nicolas Kern, Philippe Compain","doi":"10.1039/d5ob01151e","DOIUrl":"https://doi.org/10.1039/d5ob01151e","url":null,"abstract":"<p><p><i>Gem-C</i>,<i>C</i>-glycosides-<i>C</i>-glycosides characterized by two carbon substituents at the pseudo-anomeric position-constitute a structurally distinctive class of glycomimetics with growing relevance in natural products and drug discovery. These motifs appear in diverse bioactive compounds such as maitotoxin, nogalamycins, zaragozic acids and remdesivir, displaying antimicrobial, anti-inflammatory, and anticancer properties. The unique architectures of <i>gem-C</i>,<i>C</i>-glycosides expand the glycochemical space and hold promise for therapeutic development. In contrast to classical <i>C</i>-glycosyl compounds, which benefit from a well-developed synthetic toolbox, the construction of <i>gem-C</i>,<i>C</i>-glycosides remains particularly demanding. This is primarily due to the dual requirement of forming a quaternary center while achieving stereocontrol at a highly congested site. The present review surveys current strategies for constructing quaternary pseudoanomeric centers in <i>gem-C</i>,<i>C</i>-glycosides, highlighting key advances, challenges, and opportunities in this evolving field. Particular attention is given to innovative methodologies that enable direct transformation from carbohydrate precursors, including novel approaches such as metal-hydride hydrogen atom transfer (MHAT) and C-H activation processes.</p>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photocatalyst-free synthesis of quinazolinones from <i>o</i>-aminobenzamides and rongalite under visible light.","authors":"Ajithkumar Arumugam, Sharmila Nokku, Amutha Selvaganesan, Venkatramaiah Nutalapati, Gopal Chandru Senadi","doi":"10.1039/d5ob00891c","DOIUrl":"https://doi.org/10.1039/d5ob00891c","url":null,"abstract":"<p><p>A photocatalyst-free method has been developed for the synthesis of quinazolinones from <i>o</i>-aminobenzamides and rongalite as a C₁ synthon under visible light for the first time. This transformation proceeds using atmospheric oxygen as the oxidant, involving the <i>in situ</i> generation of a superoxide radical anion (O₂˙^-), as supported by EPR analysis. Additionally, the formation of H₂O₂ was confirmed by UV-Vis spectrophotometric analysis. Key features of this method include broad functional group tolerance, moderate to good yields, gram-scale applicability, and a proof-of-concept demonstration of <i>N</i>-formylation using <i>p</i>-anisidine.</p>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polypyrrole functionalized (Ti3C2Tx–SnO2 NPs) nanocomposite-based hybrid capacitive electrode for electrochemical detection of Klebsiella pneumoniae","authors":"Md. Abdul Khaleque, Moumita Rahman Sazza, Selina Akter, Md. Romzan Ali, Syed Imdadul Hossain, Rahman Saidur, Mohamed Aly Saad Aly and Md. Zaved H. Khan","doi":"10.1039/D5RA03642A","DOIUrl":"https://doi.org/10.1039/D5RA03642A","url":null,"abstract":"<p >Bacterial detection is crucial for accurate clinical diagnostics and effective environmental monitoring. Particularly, <em>Klebsiella pneumoniae</em>, a pathogenic bacterium, can cause a wide range of infections, including meningitis, bloodstream infections, pneumonia, urinary tract infections, and wound or surgical site infections. Herein, a polypyrrole (PPy) functionalized Ti<small>₃</small>C<small>₂</small>T<small>_<em>x</em></small>–tin dioxide nanoparticle (SnO<small>₂</small> NPs) nanocomposite-based hybrid capacitive electrode for the electrochemical detection of <em>Klebsiella pneumoniae</em> ATCC 700603 is developed. The PPy layer was coated onto the Ti<small>₃</small>C<small>₂</small>T<small>_<em>x</em></small>–SnO<small>₂</small> NPs <em>via</em> drop-casting, followed by immobilization of bacteriophages through a potentiostatic, charge-directed chronoamperometric approach. The resulting Ti<small>₃</small>C<small>₂</small>T<small>_<em>x</em></small>–SnO<small>₂</small> NPs/PPy/phage biosensor exhibited a wide dynamic detection range of 10 to 10<small>⁶</small> CFU mL<small>⁻¹</small>, with excellent linearity confirmed by differential pulse voltammetry and electrochemical impedance spectroscopy. The nanocomposite was characterized by using a suite of techniques including FTIR, XRD, elemental mapping, cyclic voltammetry, and galvanostatic charge–discharge to understand its composition, structure, and electrochemical properties. The developed Ti<small>₃</small>C<small>₂</small>T<small>_<em>x</em></small>–SnO<small>₂</small> NPs/PPy hybrid electrode demonstrated typical supercapacitor behavior with a specific capacitance of 806.67 F g<small>⁻¹</small> at 2.0 A g<small>⁻¹</small> of current density, and exhibited exceptional cycling stability, storing 98.3% of its capacitance after 10<small>⁴</small> consecutive cycles. The selectivity of the modified electrode to detect <em>K. pneumoniae</em> while minimizing interference from various bacterial cells was assessed, exhibiting remarkable resilience, and remaining unaffected. Additionally, after eleven successive weeks of storage, the proposed sensor showed no discernible reduction current (∼98.1%), demonstrating an excellent stability. Despite the presence of background bacterial interference in the environmental sample, <em>K. pneumoniae</em> detection remained highly reliable and consistent with recovery efficiency ranging from 99.75 to 99.90%.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 39","pages":" 32041-32055"},"PeriodicalIF":4.6,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra03642a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144990370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metal–organic framework–injectable hydrogel hybrid scaffolds promote accelerated angiogenesis for in vivo tissue engineering","authors":"Sobuj Shahidul Islam, Tatsuya Dode, Soma Kawashima, Myu Fukuoka, Takaaki Tsuruoka and Koji Nagahama","doi":"10.1039/D5RA02770E","DOIUrl":"https://doi.org/10.1039/D5RA02770E","url":null,"abstract":"<p >The application of nanoscale metal–organic frameworks (MOFs) in tissue engineering is receiving increased attention. As three-dimensional scaffolding materials that provide an appropriate extracellular microenvironment supporting the survival, proliferation, and organization of cells play a key role <em>in vivo</em> tissue engineering, hybridization of nanoscale MOFs with bulk hydrogels has led to the development of nanoscale MOF–combined hydrogels. However, development of nanoscale MOF–combined hydrogel scaffolds remains challenging. Generally, since the gelation properties of injectable hydrogels are delicate, the sol–gel transition behavior could be lost due to the influence of additives. To date, little progress has been made in the development of nanoscale MOF–combined injectable hydrogel scaffolds. Herein, we propose a novel injectable hydrogel scaffold generated by combining NU-1000 nanoscale MOFs with PLGA-PEG-PLGA/LAPONITE® nanocomposite hydrogels. The resultant PLGA-PEG-PLGA/LAPONITE®/<small>L</small>-Arg@NU-1000 hybrid hydrogels exhibited sustained slow release of <small>L</small>-arginine over 1 month. The precursor solution of PLGA-PEG-PLGA/LAPONITE®/<small>L</small>-Arg@NU-1000 undergoes rapid sol–gel transition upon exposure to body temperature, enabling focal administration of the hydrogel at desired locations in the body <em>via</em> simple injection. The sustained <small>L</small>-arginine–slow release capability of the hybrid hydrogels results from the functionality of NU-1000 as a primary carrier and efficiently facilitates angiogenesis <em>in vivo</em>. The hybrid hydrogel exhibits highly specific functionality as a scaffold that cannot be achieved using NU-1000 alone or PLGA-PEG-PLGA/LAPONITE® hydrogels alone, thus indicating that the hybrid injectable hydrogels have the potential to become a new type of scaffold for tissue engineering.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 39","pages":" 32143-32154"},"PeriodicalIF":4.6,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra02770e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144990380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of paper types based on three dimensional fluorescence spectroscopy combined with Resnet34.","authors":"Yinni Lv, Xin Lin, Peng Wang, Hongda Li","doi":"10.1039/d5ay01099c","DOIUrl":"https://doi.org/10.1039/d5ay01099c","url":null,"abstract":"<p><p>Printing paper represents one of the most prevalent forms of physical evidence in document forensics, where accurate brand and model identification provides critical investigative leads. To enable rapid, precise identification of commercial printing paper brands, we propose a novel method combining 3D fluorescence spectroscopy with an enhanced ResNet34 network. First, 3D fluorescence contour maps of diverse paper brands were acquired across excitation (280-420 nm) and emission (300-592 nm) wavelengths. These data were augmented <i>via</i> random flipping, scaling, and cropping to generate an expanded dataset of 6398 samples. Subsequently, the ResNet34 backbone was streamlined by removing redundant intermediate layers to improve efficiency. Feature extraction capabilities-particularly for central regions of fluorescence contour images-were strengthened by integrating the CBAM attention mechanism, with training dynamics visualized for optimization. Comparative experiments identified optimal training strategies and hyperparameters. The highest-performing model achieved 97.27% accuracy on the test set, significantly outperforming conventional methods. The proposed system demonstrates strong robustness with a per-image inference time of 0.82 seconds, confirming its practical utility for forensic paper analysis.</p>","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Axial engineering of bilayer single-atom catalysts for enhanced bifunctional oxygen electrocatalysis.","authors":"Xinge Wu, Wenzhu Tan, Zhaoying Yang, Chao Li, Shuai Shao, XiangYing Meng","doi":"10.1039/d5cp02199e","DOIUrl":"https://doi.org/10.1039/d5cp02199e","url":null,"abstract":"<p><p>Axial ligand engineering is a promising strategy to enhance the performance of single-atom catalysts (SACs) in electrocatalysis. However, a single non-metallic axial coordination atom linked to monolayer SACs (MSACs) often exhibits insufficient stability. In this work, we designed a series of bilayer SACs (BSACs) with vertically stacked FeN₄ and MN₄ (M = Sc-Zn) layers bridged by axial non-metallic atoms (C, N, O, P, S, and Se). The bilayer structure stabilizes axial atom anchoring and redistributes electrons of dual-side metal atoms. As electrocatalysts for oxygen reduction (ORR) and evolution (OER) reactions, the introduction of axial ligands optimizes the binding strength of key intermediates and reduces the overpotentials. After high-throughput DFT screening of the ORR/OER pathways across 60 BSAC candidates, we found that FeN₄-P-MnN₄ (P-FeMn) and FeN₄-C-MnN₄ (C-FeMn) exhibit exceptional dual-sided bifunctional (ORR and OER) catalytic activity, with ORR overpotentials (Fe/Mn site) of 0.27/0.28 V and 0.37/0.29 V and OER overpotentials of 0.42/0.37 V and 0.31/0.42 V, respectively. Electronic structure analysis reveals that the axial P/C atoms induce a transition of the metal atoms from a high-spin state to a low-spin state, thereby shifting the d-band center and effectively weakening the metal-oxygen orbital hybridization (σ and π), leading to enhanced catalytic activity. This work advances axial ligand engineering in single-atom catalysts and offers new insights and strategies for designing stable and efficient bifunctional oxygen electrocatalysts.</p>","PeriodicalId":99,"journal":{"name":"Physical Chemistry Chemical Physics","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High throughput estimates of surface tension using steady droplet deformation in pressure-driven fluidic flows.","authors":"Evyatar Shaulsky, Sabrina Marnoto, Avi J Patel, Sara M Hashmi","doi":"10.1039/d5sm00493d","DOIUrl":"https://doi.org/10.1039/d5sm00493d","url":null,"abstract":"<p><p>Advances in fluidic droplet generation both necessitate and enable accessible, high throughput methods to optimize formulations by measuring surface tension. One fluidic approach involves creating extensional flow using constrictions. Droplets deform within a constriction, and then experience extensional flow upon exiting into a wider channel. Transient relaxation of the deformed droplets, coupled with the details of the extensional flow, can be used to measure surface tension. We propose an alternative, arguably simpler approach: we use steady deformation within a constriction to measure surface tension. Our approach is motivated by the linear theories that describe droplet deformation in steady flows. These theories, encompassing both clean and surfactant covered drops in unbounded and bounded shear flows, show that droplet deformation is linear with the capillary number for small deformations. Interestingly, this steady deformation approach to estimating the capillary number, and thus, surface tension, has not been tested in pressure driven microfluidic flows. We generate and flow emulsion droplets through a series of increasingly narrow constrictions and use steady deformation to measure surface tension. We investigate both water-in-oil and oil-in-water droplets, stabilized by three different surfactants over a range of concentrations. In a subset of experiments, we vary the viscosity ratio by adding polyethylene glycol diacrylate to water droplets. Validation using both the transient deformation fluidic approach and pendant drop measurements on individual droplets demonstrates the viability of using linear scaling behavior to estimate surface tension. Our results suggest steady state deformation in pressure driven flows can be used to measure surface tension even when droplets are slightly confined. This steady droplet deformation approach to surface tension measurements represents a readily-accessible option for those using fluidic droplet generators to perform biomedical or other assays, or to investigate or optimize emulsion formulations.</p>","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metathesis and the building block approach to novel layered copper oxyselenides - useful tool or synthetic dead-end?","authors":"Liam Kemp, Geoffrey Hyett","doi":"10.1039/d5mh01350j","DOIUrl":"https://doi.org/10.1039/d5mh01350j","url":null,"abstract":"<p><p>The use of metathesis, or ionic double displacement reactions, for the synthesis of layered copper oxyselenides is explored, and compared to the conventional solid state reaction approach across a range of temperatures. We have determined that metathesis does offer some advantages in product selectivity at low temperature but due to more complex synthetic requirements does not warrant more widespread adoption.</p>","PeriodicalId":87,"journal":{"name":"Materials Horizons","volume":" ","pages":""},"PeriodicalIF":10.7,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}