{"title":"Electron-deficient B-site engineering in CeNiO<sub>3</sub> for efficient PMS activation and tetracycline degradation.","authors":"Xin Tang, Huiwei Ding, Qiaofeng Han, Guolang Zhou, Rongyao Ma, Zhipeng Xue, Shuolei Yan, Lili Zhang, Jingzhou Yin, Edison Huixiang Ang","doi":"10.1039/d5mh01099c","DOIUrl":"https://doi.org/10.1039/d5mh01099c","url":null,"abstract":"<p><p>The efficiency of peroxymonosulfate (PMS) activation in advanced oxidation processes is often hindered by weak electronic interactions between the active sites and PMS molecules. To address this challenge, this study presents the synthesis of Fe-doped CeNiO<sub>3</sub> (Fe-CNO) using a combined approach of Fe doping and a metal-organic framework (MOF)-derived strategy. The core innovation involves the introduction of Fe to induce electron-deficient B-site engineering, which strategically reconstructs the electronic structure of the original Ni sites, converting them into highly active, electron-deficient centers. Both experimental and theoretical investigations confirm that these modified centers exhibit reduced electron cloud density, thereby significantly strengthening their interaction with PMS. This enhancement facilitates an optimized electron transfer pathway, lowers the activation energy barrier for O-O bond cleavage, and promotes the generation of diverse reactive oxygen species (ROS). Concurrently, the MOF-derived architecture imparts a high specific surface area to Fe-CNO, and the increased density of active sites synergistically accelerates PMS activation. Fe-CNO achieved a TC degradation efficiency exceeding 90% within 60 minutes <i>via</i> PMS activation, nearly three times higher than that of pristine CeNiO<sub>3</sub>. Furthermore, it exhibited minimal metal leaching (<0.07 mg L<sup>-1</sup>), excellent pH tolerance (pH = 4-12), and strong cycling stability. This work provides an effective approach for designing novel, stable, and environmentally friendly catalysts and offers valuable insights into the use of CeNiO<sub>3</sub>-based perovskites in AOPs.</p>","PeriodicalId":87,"journal":{"name":"Materials Horizons","volume":" ","pages":""},"PeriodicalIF":12.2,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eun Hae Cho, Young Woo Kim, Junhee Sim, Hyejeong Yeon, Sooyeon Baek, Seung Min Jeong, Junwoo Lee, Yongmin Jeon, Kyung Cheol Choi
{"title":"Recent advances in flexible and wearable OLEDs for biomedical applications: a review.","authors":"Eun Hae Cho, Young Woo Kim, Junhee Sim, Hyejeong Yeon, Sooyeon Baek, Seung Min Jeong, Junwoo Lee, Yongmin Jeon, Kyung Cheol Choi","doi":"10.1039/d5mh00742a","DOIUrl":"https://doi.org/10.1039/d5mh00742a","url":null,"abstract":"<p><p>Light-based therapies and diagnostics have gained prominence in medicine due to their non-invasive approach and therapeutic efficacy. Among these technologies, organic light-emitting diodes (OLEDs) are emerging as promising platforms in healthcare, offering advantages such as mechanical flexibility, lightweight construction, and efficient surface emission. Initially developed for display applications, OLEDs have been adapted for biomedical use, enabling conformal integration onto the skin or within the body. Here, we present recent advances in OLED technologies for biomedical applications, focusing on the development and optimization of OLEDs to meet the specific requirements of biomedical use. Developments in device platforms-utilizing flexible substrates and free-form architectures-are discussed, enabling the realization of wearable and implantable systems. Applications are categorized based on functional mechanisms of light-based stimulation and sensing, including photobiomodulation (PBM), photodynamic therapy (PDT), optogenetics, and biosensing. Finally, we conclude by outlining key remaining challenges in the development of OLEDs for biomedical applications.</p>","PeriodicalId":87,"journal":{"name":"Materials Horizons","volume":" ","pages":""},"PeriodicalIF":12.2,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nazir Uddin, Sudipta Roy, Santanab Giri, Gitish K Dutta, Paresh Nath Chatterjee
{"title":"Decarbonative routes to generate <i>N</i>-acyliminium ion intermediates for the synthesis of 3-substituted isoindolinones <i>via</i> an intermolecular amidoalkylation reaction.","authors":"Nazir Uddin, Sudipta Roy, Santanab Giri, Gitish K Dutta, Paresh Nath Chatterjee","doi":"10.1039/d5ob00687b","DOIUrl":"https://doi.org/10.1039/d5ob00687b","url":null,"abstract":"<p><p>An alternative and unique approach for synthesizing 3-substituted isoindolinones <i>via</i> Lewis acid-catalyzed C-C bond-breaking reactions has been reported. For this purpose, we successfully generated <i>N</i>-acyliminium ion intermediates from two different substrates [through (a) an FeCl<sub>3</sub> catalyzed C<sub>sp3</sub>-C<sub>sp2</sub> bond-breaking reaction in isoindolinones bearing electron-rich and sterically bulky aryl substituents at the 3-position and (b) a ZnCl<sub>2</sub> catalyzed C<sub>sp3</sub>-C<sub>sp3</sub> bond-breaking reaction in isoindolinones bearing 1,3-diketo substituents at the 3-position of the isoindolinone starting precursors], which were trapped by appropriate nucleophiles to produce more stable γ-substituted isoindolinones in good to excellent yields. The leaving ability of 1,3-diketones is higher than that of electron-rich and sterically bulky arenes in our developed method, which results in higher yields of γ-substituted isoindolinones from the starting precursor bearing the 1,3-diketo substituents at its 3-position. Theoretical investigations were also carried out to gain insight into the two different C-C bond-cleaving reactions.</p>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Development of a size exclusion chromatography cartridge-based analytical method for determination of free drug in nano-liposomal oncology drug formulations.","authors":"Wei Zhang, Mark Paciolla, Lijun Duan, Elise Bradley, Aastha Chadha, Bhavesh Barot, Kaylee Worrell","doi":"10.1039/d4ay02124j","DOIUrl":"https://doi.org/10.1039/d4ay02124j","url":null,"abstract":"<p><p>A reliable and stability-indicating size exclusion chromatography (SEC) cartridge-based free drug testing method was developed for active loading nanoliposome formulations through a systematic development approach. The SEC spin cartridge columns (7K MWCO, 2 mL) were used for developing the liposome free drug testing procedure. The SEC cartridge column retention capacity for a Mirati drug was determined (445 μg per cartridge). SEC testing conditions were studied to achieve a good separation between liposomes and the free drug, including cartridge conditioning, buffer wash steps for liposomal drug elution, organic media wash steps for free drug elution, and sample size effect. Qualification of this newly developed SEC cartridge method has demonstrated its specificity/selectivity without interference and excellent detection linearity (correlation coefficient (<i>R</i>) > 0.999) over a study concentration range (1.0 to 46.9 μg mL<sup>-1</sup>), sufficient LOQ (0.52 μg mL<sup>-1</sup> equivalent to 1.7% of free drug in a liposome formulation at 2.5 mg mL<sup>-1</sup>), acceptable accuracy/recovery of 81 to 89% for free drug in spiked samples at 4.5%, 9%, and 18% levels (sample loading by a regular pipet) and 88 to 97% at 10% spike level (sample loading by a positive displacement pipet), good method precision (RSD (<i>n</i> = 6) of 4% NMT) for free drug determination, and 3 days solution stability for both standard and sample solutions (2-8 °C). In comparative sample testing, the SEC free drug test results were in good agreement with the solid phase extraction (SPE) test results for active loading formulations. The new method's stability-indicating ability has been proved through monitoring free drug in a liposome sample stored at -20 °C and -80 °C.</p>","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yingyu Zhou, Long Teng, Elena Ibáñez, Hongsheng Chen, Alejandro Cifuentes, Weihong Lu
{"title":"Application of Foodomics within the field of colorectal cancer prevention, diagnosis and treatment.","authors":"Yingyu Zhou, Long Teng, Elena Ibáñez, Hongsheng Chen, Alejandro Cifuentes, Weihong Lu","doi":"10.1039/d5fo00451a","DOIUrl":"https://doi.org/10.1039/d5fo00451a","url":null,"abstract":"<p><p>Colorectal cancer (CRC) is a significant global health challenge with high incidence and mortality rates. Foodomics, an interdisciplinary field combining food science with omics technologies, offers a comprehensive approach to understanding diet-CRC interactions. This review highlights the role of Foodomics in CRC prevention, diagnosis, and treatment. For prevention, Foodomics identifies bioactive dietary components such as quercetin in apples and curcumin in turmeric that can modulate gene expression and signaling pathways to reduce cancer risk. In diagnosis, metabolomics and transcriptomics are used to identify biomarkers like short-chain fatty acids (SCFAs) and specific gene transcripts (<i>e.g.</i>, SEPT9, GSTM3) that can serve as indicators for CRC presence, enabling non-invasive screening. For treatment, Foodomics integrates personalized nutrition with targeted therapies, enhancing chemotherapeutic efficacy and modulating the tumor microenvironment through dietary interventions. Despite challenges in data standardization and clinical translation, Foodomics holds great promise for advancing CRC management through precision nutrition and optimized dietary interventions. Future directions include developing standardized protocols for data analysis, validating Foodomics-based interventions through clinical trials, and training healthcare professionals in Foodomics applications.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yu Han, Xuefeng Bian, Xiao Wang, Jiaying Chen, Liu Han, Xin Sun
{"title":"Molecular aptamer beacon-based dual-mode exponential isothermal amplification for microRNA detection.","authors":"Yu Han, Xuefeng Bian, Xiao Wang, Jiaying Chen, Liu Han, Xin Sun","doi":"10.1039/d5ob00962f","DOIUrl":"https://doi.org/10.1039/d5ob00962f","url":null,"abstract":"<p><p>Due to the limiting factors associated with microRNAs (miRNAs), including their low abundance, short sequence length, and high family sequence homology, the gold standard for miRNA detection does not meet the requirements for rapid and low-cost clinical detection of miRNAs in biological samples. To this end, we developed a one-pot method called molecular aptamer beacon-utilized exponential isothermal amplification (MABEXIA) for analyzing and detecting miRNAs. This novel devolved method was analyzed using both a fluorescent dye and a horseradish peroxidase (HRP) mediated chemiluminescence reaction with luminol and hydrogen peroxide for miRNA detection. The principle of the fluorescence platform involves hybridization of the target miRNA with MAB, which results in the formation of a large amount of double-stranded (ds) DNA products under the dual catalytic action of a DNA polymerase (Klenow Fragment) and nicking endonuclease (Nb.BbvCI) at a constant temperature. Moreover, this method exhibited good detection performance and was successfully applied to 1% human serum for miRNA detection. In contrast to the fluorescence method, the chemiluminescence approach achieved miRNA detection through the targeted interaction between the activated streptavidin (SA) aptamer within the dsDNA product and SA-coated magnetic beads. This method showed a good linear relationship in the ranges of 50 fM to 50 pM for miRNA detection. Finally, this chemiluminescence approach has a detection ability comparable to that of the gold standard for miRNA detection.</p>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RSC AdvancesPub Date : 2025-07-25DOI: 10.1039/D5RA03046C
Yuqi Dai, Lanmei Zhang, Yuemeng Wang, Anni Fu, Lanling Chu and Lei Zhao
{"title":"Packed-nanofiber solid phase extraction for daidzein, genistein, glycitein in human urine and their simultaneous detection†","authors":"Yuqi Dai, Lanmei Zhang, Yuemeng Wang, Anni Fu, Lanling Chu and Lei Zhao","doi":"10.1039/D5RA03046C","DOIUrl":"https://doi.org/10.1039/D5RA03046C","url":null,"abstract":"<p >In this work, an integrated method based on the novel packed-fiber solid-phase extraction (PFSPE) combined with high-performance liquid chromatography-ultraviolet detector (HPLC-UV) detection system was proposed for the detection of daidzein, genistein and glycitein in human urine. To efficiently adsorb three kinds of isoflavones in biological fluid, polystyrene-based nanofibers were prepared and used as adsorbents in customized solid phase extraction devices. The composition of the nanofibers, the amount of different salt ions added, the type of eluent, and the interaction of eluent volume, the amounts of nanofibers added, and the extraction time were analyzed to find the optimal adsorption conditions, respectively. The method of optimal extraction conditions for the analysis of three soy isoflavones exhibited low limits of detection (LOD) and limits of quantitation (LOQ) of 1.68–2.74 μg L<small><sup>−1</sup></small> and 5.09–8.3 μg L<small><sup>−1</sup></small>, respectively, and spiked recovery of 95.2–107.1%, and has been successfully applied to human urine samples. This study demonstrated the potential of PFSPE as methods for the adsorption and detection of daidzein, genistein, glycitein in biological fluid concurrently, providing a valuable tool for pharmacokinetic studies and investigations into the metabolism and bioavailability of isoflavones.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 33","pages":" 26601-26607"},"PeriodicalIF":3.9,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra03046c?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144695671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Soft MatterPub Date : 2025-07-25DOI: 10.1039/d5sm00186b
Ezequiel E Ferrero, Eduardo A Jagla
{"title":"Cyclic perturbations facilitate athermal creep in yield-stress materials.","authors":"Ezequiel E Ferrero, Eduardo A Jagla","doi":"10.1039/d5sm00186b","DOIUrl":"https://doi.org/10.1039/d5sm00186b","url":null,"abstract":"<p><p>Yield stress materials deform irreversibly at a finite strain-rate if loaded with a fixed stress <i>σ</i> larger than some critical yield stress <i>σ</i><sub>c</sub>. When <i>σ</i> < <i>σ</i><sub>c</sub> deformation is absent, except for transient or thermally activated processes. However, the cyclic temporal variation of system parameters can induce a persistent irreversible deformation under sub-critical athermal conditions. We characterize this phenomenon using well established models in the fields of the yielding and depinning transitions. We find that the amount of deformation per cycle increases if <i>σ</i><sub>c</sub> is approached from below, and it decreases and even vanishes at a novel critical stress <i>σ</i><sub>0</sub> < <i>σ</i><sub>c</sub> when this is reached from above. Interestingly, <i>σ</i><sub>0</sub> plays a role similar to the fatigue limit in the context of fatigue damage propagation. Our study is inspired by the literature on soft Earth geophysics where soil creep mechanisms have been correlated with cyclic changes of environmental conditions, such as daily or seasonal fluctuations in temperature and humidity, which in turn promote fluctuations in the systems internal mechanical properties. We believe our findings can motivate an interdisciplinary perspective on the study of sub-critical landform evolution, as the creep of hill slopes over long periods of time.</p>","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Soft MatterPub Date : 2025-07-25DOI: 10.1039/d5sm00474h
Eleonora Foschino, Irene E Hulsen, Alessandro Ianiro, Remco Tuinier, Mark Vis
{"title":"Self-consistent field description of polyelectrolyte-grafted colloidal actuators.","authors":"Eleonora Foschino, Irene E Hulsen, Alessandro Ianiro, Remco Tuinier, Mark Vis","doi":"10.1039/d5sm00474h","DOIUrl":"https://doi.org/10.1039/d5sm00474h","url":null,"abstract":"<p><p>We present a theoretical description of actuators in prototype artificial muscle tissue by means of a self-consistent (mean field) lattice computational scheme. The actuators are composed of pH-responsive polyelectrolytes grafted at both ends between plate- or rod-like colloidal particles and immersed in an aqueous solution. We build on a model developed for grafted rods [A. Ianiro, J. A. Berrocal, R. Tuinier, M. Mayer and C. Weder, <i>J. Chem. Phys.</i>, 2023, <b>158</b>, 14901], but we specifically include weakly acidic monomers to incorporate the effects of a pH variation to trigger the expansion of the material. As a first toy model, we consider strong polyelectrolyte chains: for both plate- and rod-like colloidal particles, we obtain pressure differences of the order of tens of MPa; sufficient to generate volume variation. During actuation, the system expands and contracts by approximately one third of the polymer contour length and about 100<i>kT</i> of work per polymer chain is performed. Secondly, we show that for weakly charged polyelectrolyte chains the salt concentration can be used to tune the actuation window by multiple pH units, which is important to obtain a biocompatible range of pH values. In this scenario, we find smaller actuation pressures than for strong polyelectrolytes, but still sufficient expansion and contraction for practical purposes.</p>","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Golgi-targeting fluorescent probe for the detection of hydrazine in biological and environmental systems.","authors":"Hui-Juan Lai, Xu Wang, Yuan Wang, Wei-Na Wu, Zhi-Hong Xu","doi":"10.1039/d5ay00690b","DOIUrl":"https://doi.org/10.1039/d5ay00690b","url":null,"abstract":"<p><p>Hydrazine (N<sub>2</sub>H<sub>4</sub>) is regarded as an extremely toxic agent but it is used in large quantities as a chemical raw material in various industries, which poses a severe danger to both the environment and public health. Notably, the Golgi apparatus (GA) of hepatocytes is frequently affected by toxins in cases of hepatotoxicity. Therefore, developing a probe to monitor N<sub>2</sub>H<sub>4</sub> in environmental systems and within the GA of live cells is highly valuable. A Golgi-targeting fluorescent probe, BHMBS, is synthesized to detect N<sub>2</sub>H<sub>4</sub>. The probe BHMBS emits faint green fluorescence at 550 nm, which is remarkably enhanced after adding N<sub>2</sub>H<sub>4</sub>. The probe can detect N<sub>2</sub>H<sub>4</sub> with an ultra-short reaction time, high sensitivity, and excellent selectivity, making it a valuable tool to monitor N<sub>2</sub>H<sub>4</sub> in the real world and image the N<sub>2</sub>H<sub>4</sub> fluctuations in cells and zebrafish.</p>","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}