The Royal Society of Chemistry最新文献

{"title":"Photo/electro-mediated radical cascade functionalization/cyclization reactions involving N-acryloyl 2-aryl indoles/benzimidazoles","authors":"Fatemeh Doraghi, Amirali Abbasi, Nooshin Zomorodiyan, Shahab Kermaninia, Reza Hassanzadeh Dostkoh, Bagher Larijani and Mohammad Mahdavi","doi":"10.1039/D5RA03878B","DOIUrl":"https://doi.org/10.1039/D5RA03878B","url":null,"abstract":"<p >Indolo/benzimidazo-isoquinoline scaffolds are frequently found in many natural products, pharmaceuticals, and organic materials. Owing to their prominent properties, in recent years, numerous studies have been performed on the synthesis of indolo/benzimidazo-isoquinoline derivatives <em>via</em> photo-, and electro-promoted functionalization/cyclization reactions of <em>N</em>-acryloyl 2-aryl indoles/benzimidazoles. In this review, we describe these fascinating transformations and discuss their mechanistic insights.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 38","pages":" 31946-31964"},"PeriodicalIF":4.6,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra03878b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144990367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanomaterial-enabled drug delivery systems for circadian medicine: bridging direct rhythm modulation and chronotherapy","authors":"Muhammad Zeeshan, Juncheng Hu, Chuan-Xi Mao, Almas Danish, Ying Xiong, Muhammad Sultan Irshad, Van-Duong Dao and Zhihua Liu","doi":"10.1039/D5RA04137F","DOIUrl":"https://doi.org/10.1039/D5RA04137F","url":null,"abstract":"<p >Circadian rhythms are essential for maintaining health and homeostasis, and disruptions can lead to sleep disorders, metabolic diseases, cardiovascular diseases, and neurodegenerative conditions. Herein, we discuss the importance of circadian rhythms and the challenges in their regulation, highlighting the limitations of traditional drug delivery methods. Various nanomaterials such as liposomes, polymeric nanoparticles (PNPs), and mesoporous silica nanoparticles have unique physical and chemical properties. These characteristics allow them to deliver drugs to specific targets over a sustained period, which improves the effectiveness of treatments for circadian-related disorders. The article discusses how nanomaterials can be used to combine different treatment strategies to address the many challenges of disrupted circadian rhythms. By delivering several drugs at once, these systems can enhance treatment specificity and reduce side effects, offering a more effective approach to managing conditions such as sleep disorders and mood disorders associated with circadian misalignment. The potential for smart drug delivery systems (SDDSs) that respond to physiological cues, such as temperature or pH changes, is also explored, showcasing how these innovations could lead to more personalized and effective therapies.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 38","pages":" 31981-32008"},"PeriodicalIF":4.6,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra04137f?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144990368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CuFe2O4-catalyzed one-pot synthesis of α-substituted 2-benzofuranmethamines via tandem A3 coupling, 5-exo-dig cyclization, and 1,3-allylic rearrangement","authors":"Ashok Kumar Raigar, Manju, Kamlesh Saini and Anjali Guleria","doi":"10.1039/D5RA05808B","DOIUrl":"https://doi.org/10.1039/D5RA05808B","url":null,"abstract":"<p >A one-pot strategy was developed for the synthesis of α-substituted 2-benzofuranmethamines from salicylaldehydes, phenylacetylenes, and cyclic secondary amines using CuFe<small>₂</small>O<small>₄</small> as a bifunctional catalyst. The reaction proceeds at 80 °C in 1,4-dioxane using Cs<small>₂</small>CO<small>₃</small> as a base, enabling sequential A<small>³</small>-coupling, 5-<em>exo</em>-dig cyclization, and 1,3-allylic rearrangement in a single operation. Unlike previous methods, this protocol employs non-precious metal catalysts and mild reagents, operates under moderate conditions, and provides direct access to α-substituted 2-benzofuranmethamines in good yields (80–96%) with broad substrate compatibility. Furthermore, the catalyst is magnetically recoverable and exhibits excellent reusability over five consecutive cycles without significant loss of activity.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 39","pages":" 32108-32116"},"PeriodicalIF":4.6,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra05808b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144990378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA frameworks equipped with high-affinity multivalent aptamers for the reliable and amplified detection of a specific membrane protein.","authors":"Zhimei He, Ziyi Zhou, Qin Fan, Wenjie Xiang, Jianyong Wang, Longfei Lai, Mingzhi Zhu, Lianhui Wang, Jie Chao","doi":"10.1039/d5cc04334d","DOIUrl":"https://doi.org/10.1039/d5cc04334d","url":null,"abstract":"<p><p>A tetrahedral DNA framework-based fluorescent probe is programmed with multivalent aptamers for the precise targeting of membrane nucleolin and an initiator strand to trigger a hybridization chain reaction. Benefiting from multivalent aptamer targeting and HCR signal amplification, this probe demonstrates minimal endocytosis, enabling the reliable and amplified detection of a membrane protein biomarker.</p>","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>ortho</i>-OH/NH₂-promoted reductive deoxygenation of α,β-unsaturated ketones with HBpin.","authors":"Zhenlei Zhang, Ziyan Chen, Guohao Niu, Manqi Zhang, Wei Zhao","doi":"10.1039/d5ob01345c","DOIUrl":"https://doi.org/10.1039/d5ob01345c","url":null,"abstract":"<p><p>A solvent- and catalyst-free protocol for the selective reductive deoxygenation of α,β-unsaturated ketones with pinacolborane (HBpin) has been developed. <i>ortho</i>-OH/NH₂ groups efficiently direct the transformation, affording 2-allylphenols and 2-allylanilines under mild conditions with excellent chemo- and regioselectivity. Mechanistic studies indicate a boron-assisted hydride transfer and carbocation pathway. This work provides a sustainable and practical approach to valuable allylic scaffolds with potential applications in medicinal chemistry and materials science.</p>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterogeneous recycled carbon black derived from pyrolytic waste tire rubber with strong, wideband electromagnetic wave absorption","authors":"Qirui Sun, Zhongyi Li, Jiaqi Ye, Yuqi Zhai, Xin Ye, Liqun Zhang and Yongpeng Wang","doi":"10.1039/D5RA05326A","DOIUrl":"https://doi.org/10.1039/D5RA05326A","url":null,"abstract":"<p >To contribute to the circular and sustainable economy framework, waste tire rubber reclamation by extracting carbon black through pyrolysis and heat treatment and then ingeniously designing it as an electromagnetic wave absorbing (EWA) material is proposed herein. The results showed that the pyrolysis-recycled carbon black (RCB) was heterogeneous with multiple interfaces, making it suitable for EWA application. The RCB was processed at 500 °C–1000 °C to study the changes in the composite and microstructure as well as the EWA properties. The heterointerfaces, defects and components changed with the pyrolytic temperature, which helped to adjust the conductive loss, polarization loss, impedance matching, and electromagnetic wave (EW) transmission path, thereby obtaining different EWA performances. As a result, RCB500 exhibited a minimum reflection loss (RL<small>_min</small>) of −35.99 dB at a thickness of 2.5 mm with a low filler loading of 40 wt%. Its widest effective absorption bandwidth (EAB) can reach 3.98 GHz at a low thickness of 1.5 mm. For RCB800, the RL<small>_min</small> value can reach −34.47 dB, and the EAB<small>_max</small> value can reach 4.14 GHz at a low thickness of only 1.5 mm with a filler loading of only 30 wt%. The absorption mechanism was deeply studied. The results indicated that the carbon black pyrolysed from waste tire rubber with strong, wideband electromagnetic wave absorption can be considered a promising candidate for designing high-efficiency carbon-matrix EWA materials.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 38","pages":" 31865-31883"},"PeriodicalIF":4.6,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra05326a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144990364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diverse chemotypes of polyketides as promising antimicrobial agents: latest progress","authors":"Gautam Kumar and Sidharth Chopra","doi":"10.1039/D5RA03414K","DOIUrl":"https://doi.org/10.1039/D5RA03414K","url":null,"abstract":"<p >Microorganisms, including bacteria, viruses, fungi, and protozoa, significantly impact human health by causing infections that can lead to serious health issues, including mortality and morbidity. Antimicrobials, including antibacterials, anti-virals, anti-fungals, and anti-parasitics, effectively prevent and treat infections in humans and animals. However, pathogens have developed resistance to these antimicrobials, enabling them to survive and persist even in the presence of antibiotics. There is a pressing need to develop new antibiotics with different mechanisms of action to combat infectious diseases effectively. Nature provides a vast therapy and drug discovery resource, offering unparalleled chemical diversity and structural complexity. Among these resources, polyketide synthase machinery produces secondary metabolites in plants, animals, marine organisms, and fungi, significantly contributing to drug discovery. Notably, polyketides exhibit diverse chemotypes, which can facilitate the discovery of antimicrobial drugs. Also, polyketide-based drugs, including anti-bacterial, anti-fungal, and anti-parasitic, have been approved for treating various infectious diseases. This review summarizes recently identified natural polyketides with potential antimicrobial activities.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 39","pages":" 32080-32107"},"PeriodicalIF":4.6,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra03414k?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144998386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compound-specific stable carbon and bromine isotope analysis tracking transformation mechanisms of organobrominated contaminants: a review of principles, methodologies and applications.","authors":"Haoyu Zeng, Songsong Chen, Xiao Liu, Weiwei Zhang, Ying Liu, Yongzhi Wang, Limin Ma","doi":"10.1039/d5em00183h","DOIUrl":"https://doi.org/10.1039/d5em00183h","url":null,"abstract":"<p><p>Organobrominated contaminants, such as brominated flame retardants (BFRs), pose significant environmental risks due to their persistence, toxicity, and complex transformation pathways. Compound-specific stable isotope analysis (CSIA) of carbon (<i>δ</i>¹³C) and bromine (<i>δ</i>⁸¹Br) has emerged as a powerful tool to elucidate degradation mechanisms, particularly debromination processes that are critical to understanding environmental fate. This review synthesizes principles, methodologies, and applications of CSIA-C/Br for tracking the transformation of organobrominated pollutants, emphasizing advances in overcoming analytical challenges. Traditional techniques such as gas chromatography-quadrupole mass spectrometry (GC-qMS) and inductively coupled plasma mass spectrometry (ICP-MS) often struggle with precision and matrix interference, especially for high-boiling-point polybrominated compounds. Innovations such as Orbitrap high-resolution mass spectrometry enable precise separation of different isotopologues, minimizing isobaric interferences and enhancing reliability, with high potential for precise bromine isotope analysis. The review also underscores the urgent need for internationally certified bromine isotope reference materials and expanded isotopic databases to improve cross-laboratory comparability. By integrating carbon and bromine isotope data, this CSIA-C/Br offers transformative insights into reaction pathways, supporting environmental forensics and pollutant management. Future work must prioritize refining analytical precision, addressing low-magnitude bromine isotope effects, and advancing field-compatible methods to bridge laboratory findings with real-world environmental systems.</p>","PeriodicalId":74,"journal":{"name":"Environmental Science: Processes & Impacts","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current advancements in the investigation of mitochondria-targeting organic sensitizers in cancer immunotherapy.","authors":"Rui Jing, Shuai Si, Siyu Zhu, Xiaoying Tang, Zhenqi Jiang","doi":"10.1039/d5bm01193k","DOIUrl":"https://doi.org/10.1039/d5bm01193k","url":null,"abstract":"<p><p>Cancer immunotherapy has transformed oncological treatment paradigms, yet tumor resistance and immune evasion continue to limit therapeutic efficacy. Mitochondria-targeting organic sensitizers (MTOSs) represent an emerging class of therapeutic agents that exploit mitochondrial dysfunction as a convergent node for tumor elimination and immune activation. As central regulators of cellular metabolism, apoptotic signaling, and immune cell function, mitochondria serve as critical determinants of tumor progression and the immunological landscape within the tumor microenvironment (TME). This comprehensive review synthesizes the latest advances (2023-2025) in MTOS-mediated cancer immunotherapy, systematically examining the capacity of MTOSs to induce diverse forms of regulated cell death and orchestrate antitumor immune responses. MTOSs demonstrate remarkable versatility in triggering mitochondria-dependent apoptosis, immunogenic cell death (ICD), necroptosis, pyroptosis, ferroptosis, and autophagic cell death through strategic disruption of mitochondrial homeostasis. These sensitizers modulate key mitochondrial functions including membrane potential dynamics, reactive oxygen species (ROS) generation, electron transport chain integrity, and calcium homeostasis, thereby releasing damage-associated molecular patterns (DAMPs) that potently activate both innate and adaptive immunity. Current MTOS platforms encompass small-molecule sensitizers, polymeric nanocarriers, metal-organic complexes, and biomimetic systems, each offering distinct advantages in mitochondrial targeting and therapeutic efficacy. Clinical translation faces significant challenges including variable mitochondrial targeting efficiency due to transmembrane transport limitations and TME pH fluctuations, systemic toxicity risks from nonspecific metal ion release in metal-organic complexes, insufficient long-term biocompatibility evaluation, and the predominant reliance on simplified tumor models that inadequately reflect clinical heterogeneity and complex spatiotemporal dynamics of mitochondrial damage-immune remodeling interactions. Future research directions emphasize the multidisciplinary integration of synthetic biology, nanotechnology, and computational approaches to engineer next-generation intelligent sensitizer platforms with enhanced TME-adaptive capabilities, enabling precise mitochondrial intervention and immune modulation for improved cancer immunotherapy outcomes.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring 4D printing of smart materials for regenerative medicine applications","authors":"Budur N. Alanazi, Hoda A. Ahmed, Nuha S. Alharbi, Noura A. A. Ebrahim and Soliman M. A. Soliman","doi":"10.1039/D5RA04410C","DOIUrl":"https://doi.org/10.1039/D5RA04410C","url":null,"abstract":"<p >The field of biomaterials has evolved rapidly with the introduction of time as a transformative factor, giving rise to four-dimensional (4D) materials that can dynamically change their structure or function in response to external stimuli. This review presents a comprehensive comparison between traditional three-dimensional (3D) and emerging 4D biomaterials, highlighting the key distinctions in design, adaptability, and functionality. We explore the development of smart biomaterials at the core of 4D systems, including stimuli-responsive polymers, shape-memory materials, and programmable hydrogels. The ability of these materials to undergo controlled transformations under physiological or engineered stimuli offers promising avenues in tissue engineering, drug delivery, regenerative medicine, and soft robotics. By integrating responsiveness and temporal control, 4D biomaterials represent a paradigm shift in biomedical engineering, with the potential to revolutionize patient-specific therapies and next-generation implants. Future challenges and opportunities for clinical translation are also discussed.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 39","pages":" 32155-32171"},"PeriodicalIF":4.6,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra04410c?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144998387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}