Journal of investigative medicine high impact case reports最新文献

Delayed Diagnosis of Partial Anomalous Pulmonary Venous Return in an Adult With Pulmonary Hypertension. 成人肺动脉高压患者部分肺静脉异常回流的延迟诊断。

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-03-17 DOI: 10.1177/23247096251326474

Sathish Krishnan, Sashi Adigopula, Nitesh Gadeela

引用次数: 0

Blue Sclera to Brittle Bones: A Rare Case of Osteogenesis Imperfecta With Dentinogenesis Imperfecta and Nephrocalcinosis. 蓝巩膜至骨质脆性：罕见的成骨不全伴牙本质不全及肾钙质沉着症病例。

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-04-12 DOI: 10.1177/23247096251334237

Saad Hayat, Ahmad Roshan Mayan, Malik Wz Khan, Qazi Jawad Hayat

引用次数: 0

A Case of Omental Neuroendocrine Tumor Discovered Incidentally: Case Report. 偶然发现大网膜神经内分泌肿瘤1例。

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-03-24 DOI: 10.1177/23247096241299286

Masataka Taki, Toshikatsu Nitta, Ryutaro Kubo, Aki Yoshiyama, Hidero Yoshimoto, Masatsugu Ishii, Takashi Ishibashi, Atsushi Takeshita

{"title":"A Case of Omental Neuroendocrine Tumor Discovered Incidentally: Case Report.","authors":"Masataka Taki, Toshikatsu Nitta, Ryutaro Kubo, Aki Yoshiyama, Hidero Yoshimoto, Masatsugu Ishii, Takashi Ishibashi, Atsushi Takeshita","doi":"10.1177/23247096241299286","DOIUrl":"10.1177/23247096241299286","url":null,"abstract":"Neuroendocrine cells are distributed throughout the body's organs, though neuroendocrine neoplasms are primarily documented in the gastrointestinal tract and pancreas, with rare occurrences elsewhere. Herein, we report a case of primary neuroendocrine tumor of the omentum (omental NET) that was incidentally detected as an omental mass during preoperative screening for colorectal cancer. The patient, a 66-year-old woman, with abdominal pain and decreased oral intake, leading to a diagnosis of obstructive colorectal cancer with a large, 55 mm, mass around the gastropyloric region, which was discontinuous with the gastrointestinal tract. After the placement of a colonic stent at the site of the ascending colon cancer to decompress the colon, a laparoscopic right hemicolectomy was performed, simultaneously excising the mass. Postoperative pathology revealed a neuroendocrine tumor (NET). Subsequent examinations detected no other lesions of suspected primary disease and postoperative somatostatin scintigraphy found no other lesions, establishing a diagnosis of omental NET. The rarity of omental NETs is attributable to the absence of neuroendocrine cells in the omentum. Moreover, solid tumors originating primarily from the omentum are very rare, making preoperative diagnosis difficult; therefore, postoperative pathology should be utilized. We presented a very rare case of omental NET, previously reported only once in the literature, and believe that complete resection with minimal invasiveness should be performed for treatment of this malignancy. In addition, we emphasize the need for continued patient follow-up.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"13 ","pages":"23247096241299286"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Culprit or an Elusive Culprit in Disguise? Unraveling Wild-Type ATTR Cardiac Amyloidosis in Heart Failure With Reduced Ejection Fraction. 罕见的罪魁祸首还是伪装的难以捉摸的罪魁祸首？揭示野生型ATTR心脏淀粉样变在心力衰竭伴射血分数降低。

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-05-30 DOI: 10.1177/23247096251345712

Jose Loayza Pintado, Taiwo Ajani, Daniela Hernandez, Everardo Cobos

{"title":"A Rare Culprit or an Elusive Culprit in Disguise? Unraveling Wild-Type ATTR Cardiac Amyloidosis in Heart Failure With Reduced Ejection Fraction.","authors":"Jose Loayza Pintado, Taiwo Ajani, Daniela Hernandez, Everardo Cobos","doi":"10.1177/23247096251345712","DOIUrl":"10.1177/23247096251345712","url":null,"abstract":"Cardiac amyloidosis (CA) is a rare disorder caused by the deposition of abnormal proteins called amyloid in the myocardium, leading to dysfunction. The 2 most common forms of amyloidosis are AL (light chain) and ATTR (transthyretin). Diagnosing amyloidosis is challenging, especially in its early stages, due to its nonspecific symptoms and overlap with other conditions. Recent studies suggest that the incidence of wild-type transthyretin amyloidosis is rising, likely due to improved diagnostic techniques and an aging population. We present the case of a 72-year-old male with lower extremity edema, progressive shortness of breath, and worsening renal function. He had a significant medical history, including hypertension, small lymphocytic lymphoma, coronary artery disease, diabetes, and chronic kidney disease. Physical examination revealed orthostatic hypotension and peripheral neuropathy. Imaging showed restrictive cardiomyopathy with reduced ejection fraction. Laboratory tests confirmed anemia and proteinuria, while a bone marrow biopsy ruled out AL amyloidosis. A Tc-99m pyrophosphate scan confirmed the diagnosis of ATTR CA. ATTR often presents with multi-organ involvement, complicating diagnosis. This patient's coexisting conditions, including orthostatic hypotension and renal failure, may have been aggravated by amyloidosis. Misdiagnosis between AL and ATTR can lead to inappropriate treatments, making accurate diagnosis crucial. ATTR requires transthyretin stabilizers and symptom management, while AL needs chemotherapy. Treatment of amyloidosis must be individualized, as autonomic dysfunction, arrhythmias, and renal involvement require careful management. Early diagnosis and differentiation are essential for appropriate treatment and improved outcomes in patients with multi-organ involvement.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"13 ","pages":"23247096251345712"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zieve Syndrome Beyond Alcohol: A Case and Literature Review Highlighting Autoimmune and Nutritional Contributions to a Rare Hemolytic Triad. 酒精以外的Zieve综合征：一个病例和文献综述，强调自身免疫和营养对罕见溶血性三联症的贡献。

IF 0.8

Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-08-10 DOI: 10.1177/23247096251365747

Ijeoma Ikedum, Lukas Velmaat, Lan Huynh, Prasad Rao, Folasade Arinze

{"title":"Zieve Syndrome Beyond Alcohol: A Case and Literature Review Highlighting Autoimmune and Nutritional Contributions to a Rare Hemolytic Triad.","authors":"Ijeoma Ikedum, Lukas Velmaat, Lan Huynh, Prasad Rao, Folasade Arinze","doi":"10.1177/23247096251365747","DOIUrl":"10.1177/23247096251365747","url":null,"abstract":"Zieve syndrome is a rare alcohol-related disorder characterized by a triad of Coombs-negative hemolytic anemia, cholestatic jaundice, and transient hyperlipidemia. Its recognition is often delayed due to overlapping features with other hepatic pathologies, particularly alcoholic hepatitis. We present the case of a 35-year-old man with a history of alcohol use disorder, autoimmune hepatitis, and malnutrition who presented with jaundice, severe anemia, and hyperlipidemia. Laboratory evaluation revealed hemolytic anemia and cholestasis, and imaging showed hepatomegaly and hepatic steatosis. A clinical diagnosis of Zieve syndrome was made. Supportive care and alcohol cessation led to rapid clinical and laboratory improvement. This case highlights potential contributing factors beyond alcohol, including autoimmune liver disease and nutritional deficiency. A review of 11 published cases revealed similar patterns, suggesting that hepatic comorbidities may predispose to or exacerbate this syndrome. Clinicians should maintain a high index of suspicion for Zieve syndrome in patients with alcohol use disorder and anemia, particularly when bilirubin elevation and hyperlipidemia coexist. Prompt diagnosis may avoid unnecessary interventions and improve patient outcomes.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"13 ","pages":"23247096251365747"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12340201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144816863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rare Case of Acute Pancreatitis Presenting With ST-Segment Elevation. 以st段抬高为表现的罕见急性胰腺炎病例。

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-07-16 DOI: 10.1177/23247096251352370

Kristy Leker, Parampreet Johal

引用次数: 0

When the ECG Deceives: A Case of Pseudo-Wellens' Syndrome in the Setting of Stress-Induced Cardiomyopathy. 当心电图欺骗：一例假性韦伦斯综合征在应激性心肌病的设置。

IF 0.8

Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-09-01 DOI: 10.1177/23247096251374515

Rouba Isshak, Karolina Janiec, Sacide S Ozgur, Yezin Shamoon, Sherif Elkattawy, Abdullah Ahmad, Fayez Shamoon

{"title":"When the ECG Deceives: A Case of Pseudo-Wellens' Syndrome in the Setting of Stress-Induced Cardiomyopathy.","authors":"Rouba Isshak, Karolina Janiec, Sacide S Ozgur, Yezin Shamoon, Sherif Elkattawy, Abdullah Ahmad, Fayez Shamoon","doi":"10.1177/23247096251374515","DOIUrl":"10.1177/23247096251374515","url":null,"abstract":"Wellens' syndrome is characterized by a distinct electrocardiographic pattern, most notably biphasic or deeply inverted T waves in the anterior precordial leads, particularly V2 and V3. These findings typically reflect transient myocardial ischemia resulting from critical stenosis of the proximal left anterior descending (LAD) artery. They are often a warning sign of an impending anterior wall myocardial infarction. However, conditions such as pseudo-Wellens' syndrome can exhibit similar electrocardiogram (ECG) changes without LAD occlusion. In this case report, we describe a 71-year-old woman who presented with chest discomfort and dyspnea and was ultimately diagnosed with sepsis-induced cardiomyopathy, which produced ECG changes mimicking Wellens' syndrome despite the absence of coronary artery disease; cardiac catheterization found no significant coronary pathology. The diagnosis was determined to be stress-induced cardiomyopathy resulting from sepsis. This report highlights the importance of distinguishing between ischemic and nonischemic causes of similar ECG patterns. It emphasizes the necessity for careful diagnosis and management, particularly in complex situations like sepsis.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"13 ","pages":"23247096251374515"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Premature Coronary Artery Disease Presenting as STEMI in a Teenager. 在青少年中表现为STEMI的过早冠状动脉疾病

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 DOI: 10.1177/23247096251313985

Morni Modi, Paul Ndunda, Kalgi Modi

引用次数: 0

Suspected Transient Ischemic Attack Related to Dysfunctional Quadricuspid Aortic Valve. 怀疑与四尖瓣功能不全相关的短暂性脑缺血发作。

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 DOI: 10.1177/23247096251313625

Arun Katwaroo, Jessica Kawall, Priya Ramcharan, Valmiki Seecheran, Rajeev Seecheran, Nafeesah Ali, Shari Khan, Naveen Anand Seecheran

引用次数: 0

Application of Nuclear Medicine Liver-Spleen Scan for Evaluation of Littoral Cell Angioma of the Spleen: A Case Report. 应用核医学肝-脾扫描评价脾滨海细胞血管瘤1例。

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-06-25 DOI: 10.1177/23247096251350571

Aren Dermarderosian, Raffi Boghossian, Derek Tai, Javid Sadjadi, Mojtaba Akhtari

{"title":"Application of Nuclear Medicine Liver-Spleen Scan for Evaluation of Littoral Cell Angioma of the Spleen: A Case Report.","authors":"Aren Dermarderosian, Raffi Boghossian, Derek Tai, Javid Sadjadi, Mojtaba Akhtari","doi":"10.1177/23247096251350571","DOIUrl":"10.1177/23247096251350571","url":null,"abstract":"Littoral cell angioma (LCA) is a rare primary splenic vascular neoplasm originating from the littoral cells of the reticuloendothelial system. Splenectomy is the accepted mode of definitive diagnosis and treatment. With fewer than 200 reported cases, LCA remains poorly understood. Herein, we provide an enhanced insight into its histology and highlight the role of nuclear imaging in aiding LCA diagnosis. A 63-year-old female with a history of stage II multiple myeloma (MM) and rheumatoid arthritis was incidentally found to have a slowly enlarging splenic mass over a 6-year period. Given her candidacy for autologous hematopoietic stem cell transplantation for MM, further evaluation of the splenic lesion was pursued using nuclear medicine (NM) liver-spleen scan, which revealed a photopenic region consistent with a benign hemorrhagic mass. Subsequent splenectomy and histopathological analysis confirmed the diagnosis of LCA, with immunohistochemistry demonstrating CD68+ and CD31+ expression, highlighting LCA's unique dual histiocytic and endothelial character. This case highlights the diagnostic challenge posed by LCA due to its nonspecific clinical presentation and imaging findings. While splenectomy remains the gold standard for diagnosis, our findings suggest that NM liver-spleen scan imaging may aid in differentiating LCA from malignant splenic masses preoperatively. Furthermore, this case reinforces the association between LCA and hematologic malignancies, supporting the hypothesis that immune dysregulation may play a role in its pathogenesis. This underscores the importance of considering LCA in the differential diagnosis of splenic masses, particularly in cases involving a history of malignancy and/or immune system abnormalities.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"13 ","pages":"23247096251350571"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0