Journal of investigative medicine high impact case reports最新文献

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Overcoming Anchoring Bias: Granulomatosis With Polyangiitis in a Patient From a Tuberculosis-Endemic Region. 克服锚定偏差:结核流行地区肉芽肿伴多血管炎患者
IF 0.7
Journal of investigative medicine high impact case reports Pub Date : 2026-01-01 Epub Date: 2026-03-30 DOI: 10.1177/23247096251344722
Arianna Rahimian, Leenah Abojaib, Donias Doko, Ali Kashkouli
{"title":"Overcoming Anchoring Bias: Granulomatosis With Polyangiitis in a Patient From a Tuberculosis-Endemic Region.","authors":"Arianna Rahimian, Leenah Abojaib, Donias Doko, Ali Kashkouli","doi":"10.1177/23247096251344722","DOIUrl":"10.1177/23247096251344722","url":null,"abstract":"<p><p>The differential diagnosis of a patient presenting with constitutional symptoms and pulmonary cavitary lesions on chest X-ray is broad, including pulmonary tuberculosis (TB) and vasculitic lung disease. Clinicians may consider sociodemographic factors in sequencing their differential, which should be verified with diagnostic tests according to appropriate pretest probability. Here, we present a case of misdiagnosing granulomatosis with polyangiitis as pulmonary TB. Although native to an endemic country, this patient had multiple negative TB tests and did not respond to rifampin, isoniazid, pyrazinamide, and ethambutol therapy. We consider anchoring implicit bias as a contributing factor for this patient's misdiagnosis and make recommendations for clinicians.</p>","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"14 ","pages":"23247096251344722"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13039637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147581577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real or Not Real? An Elevated TSH. 是真的还是假的?TSH升高。
IF 0.7
Journal of investigative medicine high impact case reports Pub Date : 2026-01-01 Epub Date: 2026-03-19 DOI: 10.1177/23247096261430087
Marla E Sevilla-Alsina, Allison O Dumitriu Carcoana, Jane Y Yang, Michael J McPhaul, Mohammad Saiful Islam, Roy E Weiss
{"title":"Real or Not Real? An Elevated TSH.","authors":"Marla E Sevilla-Alsina, Allison O Dumitriu Carcoana, Jane Y Yang, Michael J McPhaul, Mohammad Saiful Islam, Roy E Weiss","doi":"10.1177/23247096261430087","DOIUrl":"10.1177/23247096261430087","url":null,"abstract":"<p><p>A 19-year-old male presented with mild fatigue and chronic constipation and was found to have an elevated thyroid-stimulating hormone (TSH) level of 85 mIU/L, normal free thyroxine, and normal total triiodothyronine. This presentation was concerning for Macro-TSH, which is rare and may suggest hypothyroidism. This patient's diagnosis of Macro-TSH was confirmed by TSH antibody testing and gel filtration chromatography. We present this case to highlight the need to further evaluate TSH results when thyroid function tests are incompatible with the clinical presentation. Assessment for TSH antibodies, a commercially available test, or gold-standard gel filtration chromatography testing, which is not commercially available, can be used to diagnose Macro-TSH.</p>","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"14 ","pages":"23247096261430087"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147486298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Malignancy in Disguise: Transudative Malignant Pleural Effusion from Early-Onset Lung Adenocarcinoma. 伪装的恶性肿瘤:由早发性肺腺癌引起的经转性恶性胸腔积液。
IF 0.7
Journal of investigative medicine high impact case reports Pub Date : 2026-01-01 Epub Date: 2026-08-10 DOI: 10.1177/23247096261478915
Ruba Habib, Rayan Sabouh, Rouba Isshak, Hala Moussa, Basel Aldroubi, George Horani, Ahmad Qatanani, Mourad Ismail
{"title":"Malignancy in Disguise: Transudative Malignant Pleural Effusion from Early-Onset Lung Adenocarcinoma.","authors":"Ruba Habib, Rayan Sabouh, Rouba Isshak, Hala Moussa, Basel Aldroubi, George Horani, Ahmad Qatanani, Mourad Ismail","doi":"10.1177/23247096261478915","DOIUrl":"10.1177/23247096261478915","url":null,"abstract":"<p><p>Malignant pleural effusions (MPEs) are almost always exudative, with only an estimated 3-4% meeting biochemical criteria for a transudate. Light's criteria remain the standard method for classifying pleural effusions, and transudative effusions typically do not undergo cytologic evaluation. This may delay the diagnosis of malignancy in rare cases where malignant cells are present in a biochemically transudative effusion. We present a 41-year-old homeless man with no established primary care who presented with progressive muscle cramping and was found to have severe electrolyte abnormalities, leukocytosis, and a right-sided pleural effusion with new bilateral pulmonary nodules on computed tomography. Pleural fluid analysis met clear transudative criteria by Light's criteria (protein ratio 0.24, LDH ratio 0.44). However, cytology revealed clusters of atypical cells consistent with pulmonary adenocarcinoma, confirmed by thyroid transcription factor-1 (TTF-1) positivity. The patient had no identifiable cause of transudative effusion, including heart failure, cirrhosis, nephrotic syndrome, or significant hypoalbuminemia. This case illustrates a rare presentation of malignant pleural effusion masquerading as a transudate in the absence of confounding systemic conditions. The mechanism likely involves early pleural metastatic involvement before the development of significant vascular permeability changes or lymphatic obstruction. This report underscores the importance of maintaining clinical suspicion for malignancy despite transudative biochemistry, particularly when features such as unilateral effusion, atypical imaging findings, or absence of an alternative systemic cause are present.</p>","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"14 ","pages":"23247096261478915"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148706781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Biochemical Spectrum of Pheochromocytoma. 嗜铬细胞瘤的生化谱。
IF 0.7
Journal of investigative medicine high impact case reports Pub Date : 2026-01-01 Epub Date: 2026-05-12 DOI: 10.1177/23247096261451176
Majlinda Xhikola, Aditya S Shirali, George A Sarosi, Juan Perdomo-Rodriguez, Sara M Falzarano, Fernanda Cordeiro-Rudnisky, Hans K Ghayee
{"title":"The Biochemical Spectrum of Pheochromocytoma.","authors":"Majlinda Xhikola, Aditya S Shirali, George A Sarosi, Juan Perdomo-Rodriguez, Sara M Falzarano, Fernanda Cordeiro-Rudnisky, Hans K Ghayee","doi":"10.1177/23247096261451176","DOIUrl":"10.1177/23247096261451176","url":null,"abstract":"<p><p>Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors that secrete catecholamines. While classic symptoms such as palpitations, sweating, and headaches may occur, many patients exhibit nonspecific or mild signs due to intermittent or low-level catecholamine secretion. This variability complicates diagnosis and increases the risk of missed or delayed detection. In this case series, we describe four patients with PPGLs demonstrating variable catecholamine secretion from overt secretion to low levels of secretion, where a clinician might incorrectly exclude the diagnosis of PPGL based on a biochemical test within the normal range. Key elements to improve detection of PPGLs from patients with minimal catecholamine secretion include a careful history on clinical symptoms of catecholamine excess, serial biochemical testing over time, utilizing nuclear medicine studies, Hounsfield units >10 from computed tomography (CT), and family history of PPGLs. Our findings from this case series help the clinician to appreciate the broad biochemical spectrum of PPGLs from no detectable or minimal catecholamine secretion to overt secretion, and how to navigate such an evaluation.</p>","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"14 ","pages":"23247096261451176"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13172712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147874325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fungating Mass of the Glans Penis: A Case Report and Discussion on Penile Squamous Cell Carcinoma. 阴茎龟头真菌团块一例报告及对阴茎鳞状细胞癌的讨论。
IF 0.7
Journal of investigative medicine high impact case reports Pub Date : 2026-01-01 Epub Date: 2026-04-13 DOI: 10.1177/23247096251381563
Dominic M Collins, Alex Marvin Simpkins, John Diks, Dale Robertson
{"title":"Fungating Mass of the Glans Penis: A Case Report and Discussion on Penile Squamous Cell Carcinoma.","authors":"Dominic M Collins, Alex Marvin Simpkins, John Diks, Dale Robertson","doi":"10.1177/23247096251381563","DOIUrl":"10.1177/23247096251381563","url":null,"abstract":"<p><p>Penile squamous cell carcinoma (PSCC) is a rare presentation in the United States and Europe, accounting for only 1% of male malignancies. Most commonly due to human papilloma virus (HPV), PSCC has an insidious onset, often ignored by patients until functional impairments are present. This report outlines an interesting presentation of penile squamous cell carcinoma while focusing on current developments in the prognosis and treatment of PSCC. We present the case of a 68-year-old male who presented with a 5 cm fungating mass of the glans penis after emergent care following a stroke. Visual inspection revealed a large mass of the glans penis which had completely obliterated the urethral meatus. A partial penectomy and urethrostomy were performed. Surgical excision revealed a unifocal moderately differentiated (G2) squamous cell carcinoma, with immunohistochemical staining demonstrating p16 positivity, consistent with HPV-associated etiology. This case highlights the importance of individualized treatment regimens and prognostic determination for optimal patient outcomes.</p>","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"14 ","pages":"23247096251381563"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13080190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147674262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inflammatory Myofibroblastic Tumor of the Lung: A Rare Find in an Elderly Female. 老年女性肺炎性肌成纤维细胞瘤的罕见发现。
IF 0.7
Journal of investigative medicine high impact case reports Pub Date : 2026-01-01 Epub Date: 2026-03-31 DOI: 10.1177/23247096261435539
Maithri Vallabhaneni, Renu Bhargavi Boyapati, Sai Samhitha Avula Balliahgari, Chukwunonso Ezeani, Ashish Dahiya, Nicholas LeBlanc, Marshall Patrick Stagg
{"title":"Inflammatory Myofibroblastic Tumor of the Lung: A Rare Find in an Elderly Female.","authors":"Maithri Vallabhaneni, Renu Bhargavi Boyapati, Sai Samhitha Avula Balliahgari, Chukwunonso Ezeani, Ashish Dahiya, Nicholas LeBlanc, Marshall Patrick Stagg","doi":"10.1177/23247096261435539","DOIUrl":"10.1177/23247096261435539","url":null,"abstract":"<p><p>Inflammatory myofibroblastic tumors (IMTs), originating from mesenchymal cells, are rare neoplasms with intermediate biological potential. Despite being predominantly benign, they can progress to locally aggressive disease and may recur over time. IMTs are predominantly seen in the pediatric population, making our case of IMT in an older adult even rarer. A 67-year-old female with a 42-pack-year smoking history presented with cough, fever, and progressively worsening exertional dyspnea. Imaging studies, including chest X-ray followed by chest computed tomography, identified a right lower lobe lung nodule without evidence of metastasis. Subsequent evaluation with robotic bronchoscopy and endobronchial ultrasound revealed densely cellular reactive lung tissue on lymph node biopsy. Ultimately, the patient underwent a robotic-assisted right lower lobectomy. Final pathology confirmed the diagnosis of an IMT. IMTs are characterized by the presence of spindle cells associated with dense monomorphic inflammatory cells. It has been found that IMT arises from chromosomal rearrangements that aberrantly activate various kinase signaling pathways. This understanding of the molecular mechanisms underlying IMT development has elucidated the neoplastic nature of the disease and has also been pivotal in distinguishing IMT from other inflammatory pseudotumors. Surgical resection remains the cornerstone of treatment, with targeted therapies offering promising results for unresectable or advanced cases. IMTs pose a multifaceted challenge in clinical practice due to their diverse clinical manifestations, histopathological variability, and unclear etiopathogenesis, underscoring the need for continued research and a multidisciplinary approach to optimize patient outcomes.</p>","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"14 ","pages":"23247096261435539"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13039607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147581572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary Adenocarcinoma Arising From Somatic-type Malignant Transformation of a Nonseminomatous Germ Cell Tumor: A Case Report. 非半细胞性生殖细胞肿瘤躯体型恶性转化引起肺腺癌1例报告。
IF 0.7
Journal of investigative medicine high impact case reports Pub Date : 2026-01-01 Epub Date: 2026-09-03 DOI: 10.1177/23247096261488201
Abdel Martinez, Brandon Cantazaro, Fatimah Bello, Christine Vega, Natacha Vargas, Payal Bhakta, Renzo Arauco
{"title":"Pulmonary Adenocarcinoma Arising From Somatic-type Malignant Transformation of a Nonseminomatous Germ Cell Tumor: A Case Report.","authors":"Abdel Martinez, Brandon Cantazaro, Fatimah Bello, Christine Vega, Natacha Vargas, Payal Bhakta, Renzo Arauco","doi":"10.1177/23247096261488201","DOIUrl":"10.1177/23247096261488201","url":null,"abstract":"<p><p>Somatic-type malignant transformation (STM) is a rare but aggressive complication of nonseminomatous germ cell tumors (NSGCTs), most commonly arising from the teratomatous component and frequently occurring in metastatic sites. We report the case of a man in his 20s with a history of mixed NSGCT (50% yolk sac tumor, 40% teratoma, and 10% embryonal carcinoma) treated with left orchiectomy and chemotherapy in 2023, who initially responded to treatment but was subsequently lost to follow-up. He presented with one week of progressive dyspnea and pleuritic left-sided chest pain. Serum alpha-fetoprotein was markedly elevated at 2,966.7 ng/mL. Computed tomography demonstrated a progressive left hilar mass causing near-complete compression of the left mainstem bronchus with postobstructive consolidation, pulmonary vein tumor thrombus extending into the left atrium, a stable subcarinal metastatic mass, and a small left pleural effusion. Brain magnetic resonance imaging and transthoracic echocardiography were unremarkable except for normal cardiac function without intracardiac thrombus. CT-guided biopsy of the lung mass demonstrated adenocarcinoma consistent with a pulmonary phenotype. Following multidisciplinary evaluation, the lesion was determined to represent pulmonary adenocarcinoma arising from somatic-type malignant transformation of the teratomatous component of recurrent NSGCT. The patient remained clinically stable and was managed with close airway surveillance after Pulmonary and Critical Care Medicine consultation, with airway stenting or endobronchial debulking reserved for clinical deterioration. This case highlights the importance of recognizing STM in patients with recurrent NSGCT, as accurate diagnosis requires integration of clinical history, imaging, and pathology and has significant therapeutic and prognostic implications.</p>","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"14 ","pages":"23247096261488201"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13546417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148887764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retropharyngeal Ectopic Parathyroid Gland Presenting as Primary Hyperparathyroidism: A Diagnostic Challenge From the Endocrine Perspective. 咽后异位甲状旁腺表现为原发性甲状旁腺功能亢进:从内分泌角度诊断的挑战。
IF 0.7
Journal of investigative medicine high impact case reports Pub Date : 2026-01-01 Epub Date: 2026-10-26 DOI: 10.1177/23247096261503836
Mariam S Alharbi
{"title":"Retropharyngeal Ectopic Parathyroid Gland Presenting as Primary Hyperparathyroidism: A Diagnostic Challenge From the Endocrine Perspective.","authors":"Mariam S Alharbi","doi":"10.1177/23247096261503836","DOIUrl":"https://doi.org/10.1177/23247096261503836","url":null,"abstract":"<p><p>Ectopic parathyroid tissue is an unusual yet clinically significant contributor of primary hyperparathyroidism (PHPT), especially when standard localization studies yield inconclusive results. Retropharyngeal ectopic parathyroid glands are uncommon and may postpone diagnosis due to their unusual anatomical location. This report details a case of a 39-year-old woman exhibiting hypercalcemia, musculoskeletal pain, constipation, a history of nephrolithiasis, and diminished bone mineral density. Biochemistry showed that parathyroid hormone (PTH) levels were always high, with occasional hypercalcemia and hypercalciuria, which is what you would expect with PHPT. Ultrasound of the neck did not show a parathyroid lesion. Cross-sectional imaging and fluorocholine PET/CT identified a retropharyngeal soft tissue nodule indicative of ectopic parathyroid tissue. Histopathology following biopsy confirmed parathyroid tissue. This case highlights the endocrine diagnostic pathway in PHPT, the importance of correlating biochemical findings with advanced imaging, and the need to consider ectopic glands when first-line imaging is negative.</p>","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"14 ","pages":"23247096261503836"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149269048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary Lung Adenocarcinoma as a Second Neoplasm Following Chronic Lymphocytic Leukemia: A Case Report. 原发性肺腺癌作为慢性淋巴细胞白血病后的第二肿瘤:1例报告。
IF 0.7
Journal of investigative medicine high impact case reports Pub Date : 2026-01-01 Epub Date: 2026-05-14 DOI: 10.1177/23247096261440366
Liliana Fernández-Trujillo, Luz F Sua, Juan P Muñoz-Manzano, Ciro D Ibarra-Enriquez, Juan C Bravo
{"title":"Primary Lung Adenocarcinoma as a Second Neoplasm Following Chronic Lymphocytic Leukemia: A Case Report.","authors":"Liliana Fernández-Trujillo, Luz F Sua, Juan P Muñoz-Manzano, Ciro D Ibarra-Enriquez, Juan C Bravo","doi":"10.1177/23247096261440366","DOIUrl":"10.1177/23247096261440366","url":null,"abstract":"<p><p>Chronic lymphocytic leukemia (CLL) and its variant, small lymphocytic lymphoma (SLL), are common adult leukemias characterized by the accumulation of mature monoclonal B lymphocytes. CLL primarily involves peripheral blood, spleen, and lymph nodes, whereas SLL predominantly affects lymph nodes. Patients with CLL/SLL are at increased risk of developing second primary malignancies, including lung cancer, highlighting the need for ongoing surveillance. We report the case of an 83-year-old man with a history of CLL/SLL who developed pulmonary adenocarcinoma. He presented weight loss and constitutional symptoms; imaging revealed retroperitoneal and mesenteric lymph node conglomerates along with a lung lesion. Histopathology confirmed SLL in the lymph nodes and primary mucinous adenocarcinoma of the lung. Evidence shows a heightened risk of second primary neoplasms in CLL/SLL, particularly among patients exposed to alkylating agents. This case emphasizes the role of demographic and treatment-related factors-such as male sex, advanced age, smoking history, and therapeutic regimens-in secondary cancer development. Vigilant monitoring and a multidisciplinary approach tailored to individual risk are essential for early detection and optimal management in this population.</p>","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"14 ","pages":"23247096261440366"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13180051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147941737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aggressive Seropositive Rheumatoid Arthritis With Diffuse Osteolytic Bone Lesions, Hypercalcemia, and Lymphadenopathy Masquerading as Hematologic Malignancy: A Case Report. 侵袭性血清阳性类风湿关节炎伴弥漫性骨溶解性病变、高钙血症和伪装为血液恶性肿瘤的淋巴结病:1例报告。
IF 0.7
Journal of investigative medicine high impact case reports Pub Date : 2026-01-01 Epub Date: 2026-05-14 DOI: 10.1177/23247096261451191
Lavanya Kannekanti, Tarun Selvarajan, Shilpa Raman Danagara, Shravya Balmuri, Alberto Simoncini, Xiaoming Fan, Samina Hayat
{"title":"Aggressive Seropositive Rheumatoid Arthritis With Diffuse Osteolytic Bone Lesions, Hypercalcemia, and Lymphadenopathy Masquerading as Hematologic Malignancy: A Case Report.","authors":"Lavanya Kannekanti, Tarun Selvarajan, Shilpa Raman Danagara, Shravya Balmuri, Alberto Simoncini, Xiaoming Fan, Samina Hayat","doi":"10.1177/23247096261451191","DOIUrl":"10.1177/23247096261451191","url":null,"abstract":"<p><p>Aggressive seropositive rheumatoid arthritis (RA) typically manifests with marginal joint erosions and periarticular osteopenia but rarely presents with diffuse osteolytic lesions mimicking malignancy. A 65-year-old woman presented with subacute back pain and incidentally discovered hypercalcemia (calcium 12.7 mg/dL). Imaging revealed multifocal lytic lesions of the axial and appendicular skeleton highly suggestive of multiple myeloma or metastatic disease, along with supraclavicular lymphadenopathy. Extensive evaluation including bone marrow biopsy demonstrated polyclonal plasmacytosis without evidence of hematologic malignancy. Lymph node excision revealed reactive follicular hyperplasia. Subsequent rheumatologic assessment identified symmetric inflammatory polyarthritis, rheumatoid nodules, rheumatoid factor 191 IU/mL, and anti-cyclic citrullinated peptide (anti-CCP) antibodies 2630 U/mL, establishing the diagnosis of aggressive seropositive RA. Bursectomy of a right elbow mass confirmed necrobiotic granulomatous inflammation consistent with a rheumatoid nodule. Treatment with methotrexate, leflunomide, and rituximab led to resolution of hypercalcemia, substantial improvement in joint symptoms, and radiographic stabilization of lytic lesions. This case highlights how RANKL-mediated osteoclast activation and anti-CCP antibody-driven bone resorption can, in rare instances, produce malignancy-mimicking diffuse osteolysis and hypercalcemia, and underscores the importance of considering RA in the differential diagnosis of diffuse lytic bone lesions. The diagnosis was supported by fulfillment of 2010 ACR/EULAR classification criteria, histologic confirmation of rheumatoid nodules, and dramatic response to disease-modifying antirheumatic therapy.</p>","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"14 ","pages":"23247096261451191"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13180070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147941649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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