Journal of investigative medicine high impact case reports最新文献

A Unique Case of Mesenteric Gastrointestinal Stromal Tumor Presenting as an Acute Abdomen. 以急性腹部为表现的肠系膜胃肠道间质瘤的独特病例

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241253348

Lefika Bathobakae, Rammy Bashir, Sebastian Vera, Saif Yasin, Atang Koodirile, Ratul Bhattacharyya, Mehandar Kumar

{"title":"A Unique Case of Mesenteric Gastrointestinal Stromal Tumor Presenting as an Acute Abdomen.","authors":"Lefika Bathobakae, Rammy Bashir, Sebastian Vera, Saif Yasin, Atang Koodirile, Ratul Bhattacharyya, Mehandar Kumar","doi":"10.1177/23247096241253348","DOIUrl":"10.1177/23247096241253348","url":null,"abstract":"Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the digestive tract and arise from the interstitial cells of Cajal in the mesenteric plexus. These tumors can originate in any part of the GI tract; however, a higher burden has been observed in the stomach and small intestines. Mesenteric GISTs are exceedingly rare, with unique clinicopathological features and a poorer prognosis. Herein, we describe a unique case of a 66-year-old female with a remote history of appendectomy who presented to the emergency room complaining of severe abdominal pain and vomiting. On imaging, the patient was found to have a large inflammatory mass associated with small bowel loops, and the pathology confirmed a mesenteric GIST. The tumor was resected, and the genomic test results confirmed the KIT (exon 11) mutation. Although the tumor had a low mitotic rate, the tumor was large enough to warrant the initiation of adjuvant imatinib mesylate for 36 months with regular bloodwork and imaging.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11102691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140957705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Primary B-Cell Lymphoma of the Pancreas. 一个罕见的胰腺原发性 B 细胞淋巴瘤病例

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241263536

Dayana Nasr, John Joyce, Vishnu Kumar, Hafiz M Khan, Savio John, Sidhartha Chaudhry

引用次数: 0

Granulomatous Polyangiitis Refractory to Induction With Rituximab in 3 Patients. 3名患者的肉芽肿性多血管炎对利妥昔单抗诱导治疗无效

IF 1.2

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096231215730

Nouran Eshak, Grace Ehikhueme, Malvika Ramesh, John Pixley

引用次数: 0

Cocaine Gut: A Rare Case of Cocaine-Induced Esophageal, Gastric, and Small Bowel Necrosis. 可卡因肠：可卡因诱发食道、胃和小肠坏死的罕见病例。

IF 1.2

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241242569

Lefika Bathobakae, Sacide S Ozgur, Rammy Bashir, Tyler Wilkinson, Phenyo Phuu, Ruhin Yuridullah, Gabriel Melki, Jessica Escobar, Sohail Qayyum

{"title":"Cocaine Gut: A Rare Case of Cocaine-Induced Esophageal, Gastric, and Small Bowel Necrosis.","authors":"Lefika Bathobakae, Sacide S Ozgur, Rammy Bashir, Tyler Wilkinson, Phenyo Phuu, Ruhin Yuridullah, Gabriel Melki, Jessica Escobar, Sohail Qayyum","doi":"10.1177/23247096241242569","DOIUrl":"10.1177/23247096241242569","url":null,"abstract":"Cocaine is an indirect-acting sympathomimetic drug that inhibits norepinephrine and dopamine reuptake in the adrenergic presynaptic cleft. Cocaine use has been associated with strokes, angina, arrhythmias, and agitation. Data on gastrointestinal complications such as mesenteric ischemia, bowel necrosis, ulceration, and perforation are scarce. Here, we present a rare case of cocaine-induced esophageal, gastric, and small bowel necrosis that contributes to the limited literature on this subject. Diagnosis of cocaine-induced gastrointestinal complications involves a combination of imaging studies, laboratory assessments, and histopathological examinations. Timely surgical resection, supported by intravenous fluids, antibiotics, and pain management, is the mainstay of treatment. The prognosis varies but is significantly influenced by the promptness and effectiveness of the intervention, underscoring the importance of vigilant clinical care in such cases.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10981220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140305905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Steven-Jonhson Syndrome in a Patient With Dengue Infection in Peru: A Case Report. 秘鲁登革热感染患者的 Steven-Jonhson 综合征：病例报告。

IF 1.2

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241242574

Winny D Aparcana-Choque, Yadira M Pisconti-Palacios, Ivan Cordova-Tello, Jhon Ausejo-Galarza, Walter Gomez-Gonzales, Andrei Kochubei-Hurtado, Kovy Arteaga-Livias

引用次数: 0

Breast Pain Differential: Mondor's Disease of the Breast. 乳房疼痛的鉴别：蒙多乳腺病

IF 1.2

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241246621

LaRae L Seemann, Tina Ardon, Rebecca A Bowie, Kati C Bullock, Adrianna D M Clapp

{"title":"Breast Pain Differential: Mondor's Disease of the Breast.","authors":"LaRae L Seemann, Tina Ardon, Rebecca A Bowie, Kati C Bullock, Adrianna D M Clapp","doi":"10.1177/23247096241246621","DOIUrl":"10.1177/23247096241246621","url":null,"abstract":"Breast pain is a common concern among women in primary care clinics. A rare cause of breast pain is Mondor's disease (MD), which can present as an acute, painful, erythematous, cord-like induration on the breast or anterior chest wall. The disorder is caused by sclerosing superficial thrombophlebitis of the anterolateral thoracoabdominal wall veins. There does not appear to be a racial or ethnic propensity for this condition; however, it is important to understand that it may be more difficult to see in darker skin types (Fitzpatrick skin types IV-VI) and requires close attention on physical exam. The cause of MD is poorly understood but may be related to direct trauma, strenuous exercise, or hormone changes. We review a case of a 54-year-old woman who presented with an anterior chest wall palpable cord, better visualized with adequate lighting and skin traction, ultimately diagnosed as MD based on clinical findings and imaging studies. Mondor's disease often resolves spontaneously with supportive care, as in this patient's case; however, clinicians should be aware of this rare cause of breast pain and its association with hypercoagulable state, vasculitis, and breast cancer.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11010737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140866200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis of Angioimmunoblastic T Cell Lymphoma After Receiving First Dose of Pfizer/BioNTech (BNT162b2) Vaccine: A Case Report. 首剂辉瑞/BioNTech (BNT162b2) 疫苗接种后诊断出血管免疫母细胞 T 细胞淋巴瘤：病例报告。

IF 1.2

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241231645

Jai Kumar Khatri, Ihab Tahboub, Khurram Anwar, Moh'd Masoudi, Vincent Graffeo, Muhammad Omer Jamil

{"title":"Diagnosis of Angioimmunoblastic T Cell Lymphoma After Receiving First Dose of Pfizer/BioNTech (BNT162b2) Vaccine: A Case Report.","authors":"Jai Kumar Khatri, Ihab Tahboub, Khurram Anwar, Moh'd Masoudi, Vincent Graffeo, Muhammad Omer Jamil","doi":"10.1177/23247096241231645","DOIUrl":"10.1177/23247096241231645","url":null,"abstract":"Pfizer/BioNTech (BNT162b2) is a messenger RNA (mRNA) vaccine that is highly effective in preventing the most severe outcomes of COVID-19 infection. Nucleoside-modified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccines induce effective stimulation of T follicular helper (TFH) cells, leading to a robust germinal center B cell response. Side effects from the BNT162b2 vaccination, including significant lymphadenopathy, have been reported previously. Here, we present a case of angioimmunoblastic lymphoma (AITL), a rare, peripheral T-cell lymphoma with RHOA-G17v-mutated gene developing in a patient following BNT162B2 vaccine with a plausible explanation. A 60-year-old Asian female received her first dose of Pfizer BNT162B2 mRNA vaccine in August 2021. Right after her vaccination, she developed right axillary lymphadenopathy. She received her second vaccine dose in September 2021. Thereafter, she developed lymph node (LN) enlargement in her neck and groin. She underwent left posterior cervical and left groin LN excisional biopsy in April 2022 due to persistent palpable lymphadenopathy. Biopsy results then demonstrated benign follicular hyperplasia. For progressive B symptoms, a right axillary LN biopsy was done, which demonstrated AITL, with molecular studies revealing mutation in TET-2, IDH-2, and RHOA-G17v genes. Progression of AITL following BNT162B2 mRNA vaccine is limited in literature. Our case demonstrates a plausible correlation between the diagnosis of AITL following mRNA vaccination due to the malignant transformation of the TFH cells in patients who have a predisposing mutation of RHOA-17v. Given the rarity of AITL and the heterogeneity of molecular findings, more studies are needed to establish such an association.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11102676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140957797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Tirzepatide Drop: Beware of Slimmer's Paralysis. 替扎帕肽降价：谨防斯利默麻痹症

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241264635

John M Tucker, Jordan Ritchie

引用次数: 0

Anti-Tubular Basement Membrane Antibody Nephritis Manifesting in a Patient With Chronic Lymphocytic Leukemia: A Very Rare Case Report. 慢性淋巴细胞白血病患者出现的抗小管基底膜抗体肾炎：非常罕见的病例报告

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241281612

Niloufar Ebrahimi, Behzad Najafian, Yan Chen Wongworawat, Sayna Norouzi, Amir Abdipour

引用次数: 0

Usage of Padlock Over-the-Scope-Clip in Difficult-to-Control Recurrent Gastrointestinal Bleeding Due to a Gastric Dieulafoy Lesion. 在胃蝶鞍病变导致的难以控制的复发性消化道出血中使用挂锁式蝶鞍夹。

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241263062

John Joyce, Vishnu Kumar, Dayana Nasr, Ganesh Aswath, Hafiz M Khan, Savio John

引用次数: 0