Journal of investigative medicine high impact case reports最新文献

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A Rare Case of Anti-TIF-1γ Antibody Positive Dermatomyositis in Adulthood. 一例罕见的成年期抗 TIF-1γ 抗体阳性皮肌炎病例
IF 0.9
Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241263065
Upasana Agrawal, Manush Sondhi, Alexandra Zamora Smith, Syeda Sara Nida, Sarwat Umer, Samina Hayat, Kinza Muzaffar
{"title":"A Rare Case of Anti-TIF-1γ Antibody Positive Dermatomyositis in Adulthood.","authors":"Upasana Agrawal, Manush Sondhi, Alexandra Zamora Smith, Syeda Sara Nida, Sarwat Umer, Samina Hayat, Kinza Muzaffar","doi":"10.1177/23247096241263065","DOIUrl":"10.1177/23247096241263065","url":null,"abstract":"<p><p>Dermatomyositis (DM) presents with inflammatory myopathy and distinct skin manifestations, often linked to specific autoantibodies. Anti-transcriptional intermediary factor-1 gamma (TIF-1γ) antibodies (Abs) are typically linked to DM in older patients and malignancy in 15% to 40% of cases. We highlight a case of a 24-year-old female who presented with weakness of proximal muscles, periorbital edema, heliotrope rash, erosions on oral mucosa, and painful scaly rash on the lower extremities. Transcriptional intermediary factor-1 gamma Abs were positive, confirming inflammatory myopathy. Treatment with steroid pulse therapy and immunoglobulin led to improvement. Evaluation for malignancy yielded unremarkable results. This case underscores the importance of recognizing and managing DM with TIF-1γ Ab positive, even in atypical demographics, and highlights the need for comprehensive malignancy evaluation.</p>","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"12 ","pages":"23247096241263065"},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11193338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141432117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Usage of Padlock Over-the-Scope-Clip in Difficult-to-Control Recurrent Gastrointestinal Bleeding Due to a Gastric Dieulafoy Lesion. 在胃蝶鞍病变导致的难以控制的复发性消化道出血中使用挂锁式蝶鞍夹。
IF 0.9
Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241263062
John Joyce, Vishnu Kumar, Dayana Nasr, Ganesh Aswath, Hafiz M Khan, Savio John
{"title":"Usage of Padlock Over-the-Scope-Clip in Difficult-to-Control Recurrent Gastrointestinal Bleeding Due to a Gastric Dieulafoy Lesion.","authors":"John Joyce, Vishnu Kumar, Dayana Nasr, Ganesh Aswath, Hafiz M Khan, Savio John","doi":"10.1177/23247096241263062","DOIUrl":"10.1177/23247096241263062","url":null,"abstract":"<p><p>Dieulafoy's lesions (DLs) are a rare cause of acute gastrointestinal bleeds (GIBs). Here we describe Over-the-Scope Clip Padlock System (OTSC-P) use to treat a gastric fundus DL with recurrent bleeding despite other interventions. The OTSC-P was created for full-thickness defect closure in the event of a perforation, but use has expanded to treatment of GIB. They consist of metal clips mounted on transparent caps, delivered via endoscope. Their size allows control of larger bleeding lesions, provides enhanced tissue stability and the firmer clip grasp reduces rebleeding or clip dislodgement.</p>","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"12 ","pages":"23247096241263062"},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11268008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cefepime Neurotoxicity in Patients With Normal Renal Function: An Overlooked Cause of Encephalopathy in the Intensive Care Unit. 肾功能正常患者的头孢吡肟神经毒性:重症监护病房脑病的一个被忽视的原因。
IF 0.9
Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241259534
Zakaria Alagha, Samuel Crow, Abdul Muhsen Z Abdeen, Maha Alastal, Amro Alastal
{"title":"Cefepime Neurotoxicity in Patients With Normal Renal Function: An Overlooked Cause of Encephalopathy in the Intensive Care Unit.","authors":"Zakaria Alagha, Samuel Crow, Abdul Muhsen Z Abdeen, Maha Alastal, Amro Alastal","doi":"10.1177/23247096241259534","DOIUrl":"10.1177/23247096241259534","url":null,"abstract":"<p><p>Cefepime is a fourth-generation cephalosporin with extended antimicrobial coverage. Concerns have been raised about the side effects of cefepime including myoclonus, encephalopathy, and seizures, especially when renal impairment is present. There have been reports of cases of adverse neurological consequences despite appropriate renal adjustment. Here, we present a case of a 69-year-old patient initially diagnosed with pneumonia and treated with cefepime. The patient later developed altered mental status, leading to differential diagnoses including stroke, drug overdose, or non-convulsive seizures. Following a comprehensive workup, it was determined that she had cefepime-induced encephalopathy, despite having normal kidney function, which resolved completely after discontinuing the medication. In addition, we include similar cases retrieved from PubMed up to the present date, to the best of our knowledge.</p>","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"12 ","pages":"23247096241259534"},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11284772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141788342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is There a Baby in the Lung? A Case of Placental Transmogrification of the Lung. 肺里有婴儿吗?一例胎盘肺变性病例。
IF 0.9
Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241261322
Mohammad Abdulelah, Nicole Kasher, Gabriella Primera, Jessika Matta, Ruchi Patel, Karim Anis, Ernest DiNino
{"title":"Is There a Baby in the Lung? A Case of Placental Transmogrification of the Lung.","authors":"Mohammad Abdulelah, Nicole Kasher, Gabriella Primera, Jessika Matta, Ruchi Patel, Karim Anis, Ernest DiNino","doi":"10.1177/23247096241261322","DOIUrl":"10.1177/23247096241261322","url":null,"abstract":"<p><p>Pulmonary nodules are commonly encountered in pulmonary practice. Etiologies could include infectious, inflammatory, and malignant. Placental transmogrification of the lung is an extremely rare etiology of pulmonary nodules. Such condition often presents as unilateral lesions in asymptomatic men. In general, such nodules are generally stable and grow extremely slowly. We highlight an unusual case of placental transmogrification of the lung (PLC) identified in a young female. The patient's bilateral nodules were larger than what has been previously cited in the literature and exhibited growth over an 8-year follow-up period.</p>","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"12 ","pages":"23247096241261322"},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11185031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141331093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neonatal Chronic Granulomatous Disease With Septic Arthritis and Osteomyelitis: Diagnostic and Therapeutic Challenge With Literature Review. 新生儿慢性肉芽肿病合并脓毒性关节炎和骨髓炎:诊断和治疗的挑战与文献综述
IF 0.9
Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241304534
Sura Abd Alwahab, Hussein Mohsin Hasan, Nabeel Al-Fatlawi, Sajjad Ghanim Al-Badri
{"title":"Neonatal Chronic Granulomatous Disease With Septic Arthritis and Osteomyelitis: Diagnostic and Therapeutic Challenge With Literature Review.","authors":"Sura Abd Alwahab, Hussein Mohsin Hasan, Nabeel Al-Fatlawi, Sajjad Ghanim Al-Badri","doi":"10.1177/23247096241304534","DOIUrl":"10.1177/23247096241304534","url":null,"abstract":"<p><p>This case report underlines the diagnostic and therapeutic dilemmas in a 19-day-old neonate who had presented with features suggestive of chronic granulomatous disease (CGD). The baby had a history of fever, lethargy, and masses on the skin, for which an extensive diagnostic workup was needed to rule out infective etiology given no improvement with initial empiric therapy. Laboratory investigations, including imaging and genetic studies, confirmed the diagnosis of CGD. In addition to the very early manifestation of disease, which is quite rare, our case emphasizes the importance of maintaining a high index of suspicion for immunodeficiency disorders in neonates with severe infections. The report highlights the fact that a high level of suspicion for an underlying immunodeficiency, especially conditions like CGD, must be maintained in neonates with unexplained symptoms, and the diagnosis has to be multidisciplinary in terms of management. Considering its rare inflammatory complications in neonatal CGD, the present case adds important data to the pediatric medical literature. It emphasizes that critical clinical evaluation and detailed diagnostic procedures are mandatory in cases of rare neonatal sepsis and inflammatory disorders.</p>","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"12 ","pages":"23247096241304534"},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142790641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary Thyroid Lymphoma: A Rare Diagnosis Treated With Polatuzumab Vedotin. 原发性甲状腺淋巴瘤:用Polatuzumab Vedotin治疗的罕见诊断。
IF 0.9
Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241299566
Rupam Sharma, Arin Orogian, Ralph Garcia-Pacheco, Tung Trang, Matthew Clarke, William Stull, Stanley Kim
{"title":"Primary Thyroid Lymphoma: A Rare Diagnosis Treated With Polatuzumab Vedotin.","authors":"Rupam Sharma, Arin Orogian, Ralph Garcia-Pacheco, Tung Trang, Matthew Clarke, William Stull, Stanley Kim","doi":"10.1177/23247096241299566","DOIUrl":"10.1177/23247096241299566","url":null,"abstract":"<p><p>Primary thyroid lymphoma is one of the rare and distinct type of extra nodal lymphomas originating within the thyroid gland. It accounts for less than 5% of all thyroid malignancies and 2% of extra nodal lymphomas. It predominantly affects older adults, with a higher incidence in women. Patients typically present with a rapidly enlarging thyroid mass, accompanied by clinical symptoms of compression such as dysphagia, dyspnea, and hoarseness. Diagnosis is established through a combination of fine-needle aspiration, core needle biopsy, and advanced imaging techniques. Standard treatment involves a multimodal strategy of chemotherapy, often with the addition of radiotherapy and surgical intervention. Herein presented is the first reported case of diffuse large B-cell lymphoma treated with Pola-R-CHP.</p>","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"12 ","pages":"23247096241299566"},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complete Pathologic Response With Pembrolizumab and Enfortumab Vedotin in Urothelial Carcinoma of the Upper Urinary Tract. 使用 Pembrolizumab 和 Enfortumab Vedotin 治疗上尿路上皮癌的完全病理反应
IF 0.9
Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241257333
Kok Hoe Chan, Tung Shu, Majd Al Shaarani, Putao Cen
{"title":"Complete Pathologic Response With Pembrolizumab and Enfortumab Vedotin in Urothelial Carcinoma of the Upper Urinary Tract.","authors":"Kok Hoe Chan, Tung Shu, Majd Al Shaarani, Putao Cen","doi":"10.1177/23247096241257333","DOIUrl":"10.1177/23247096241257333","url":null,"abstract":"<p><p>Urothelial carcinoma of the upper urinary tract (UTUC) presents a significant clinical challenge, often requiring aggressive surgical intervention for optimal management. We present a case of an 84-year-old woman with recurrent high-grade papillary UTUC of the left renal pelvis, refractory to prior endourologic interventions, who underwent neoadjuvant treatment with pembrolizumab and enfortumab vedotin (Pembro/EV) due to contraindications to cisplatin therapy. Following a favorable response to neoadjuvant therapy, the patient underwent laparoscopic left radical nephroureterectomy, achieving a pathologic complete response. We discuss the utility of Pembro/EV in the perioperative management of patients with UTUC, particularly in those ineligible for cisplatin-based therapy. In addition, we highlight the potential role of somatic mutation testing and the integration of novel therapeutic agents such as olaparib in personalized treatment strategies for UTUC. This case underscores the importance of exploring innovative treatment approaches and optimizing patient selection for kidney preservation strategies in the management of UTUC. Further research and clinical trials are warranted to elucidate the full therapeutic potential of Pembro/EV and other emerging therapies in this setting.</p>","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"12 ","pages":"23247096241257333"},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141158098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sarcoidosis Presenting as Granulomatous Mastitis, Erythema Nodosum, and Arthritis Syndrome: A Case Report and Comprehensive Review of the Literature. 肉样瘤病表现为肉芽肿性乳腺炎、结节性红斑和关节炎综合征:病例报告和文献综述。
IF 0.9
Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241267146
Aseel Abuhammad, Maram Albandak, Mohammed Ayyad, Arein Madia, Osama N Dukmak, Laith Alamleh
{"title":"Sarcoidosis Presenting as Granulomatous Mastitis, Erythema Nodosum, and Arthritis Syndrome: A Case Report and Comprehensive Review of the Literature.","authors":"Aseel Abuhammad, Maram Albandak, Mohammed Ayyad, Arein Madia, Osama N Dukmak, Laith Alamleh","doi":"10.1177/23247096241267146","DOIUrl":"10.1177/23247096241267146","url":null,"abstract":"<p><p>Granulomatous mastitis (GM) is a long-term inflammatory disease of the breast that usually occurs in women of reproductive age. Autoimmune mastitis is one of the most common pathological breast conditions necessitating tailored treatment. However, GM as a first clinical manifestation of sarcoidosis is uncommon. Simultaneous occurrence of GM, erythema nodosum (EN), and arthritis, termed \"GMENA\" syndrome, is a rare clinical entity associated with autoimmune rheumatic diseases. Herein, we report the case of a 31-year-old female patient with GMENA syndrome, who presented with a painful nodule of the left breast. Initial treatment entailed antibiotics under the presumption of a breast abscess, yielding negligible improvement. During this period, the patient developed polyarthritis and bilateral EN on the lower extremities. Histopathologic examination of the breast tissue exhibited noncaseating granulomas. The patient responded positively to prednisolone and methotrexate treatment. Literature review revealed a coherent pattern across GMENA cases. Our findings suggest that the \"GMENA\" syndrome represents a unique acute manifestation of sarcoidosis and highlight the necessity for heightened awareness, accurate diagnosis, and tailored therapeutic approaches for GMENA syndrome. Further research is warranted to elucidate its cause and optimize patient management. This case highlights the importance of identifying and effectively managing such interrelated clinical presentations.</p>","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"12 ","pages":"23247096241267146"},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11284773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141788344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tocilizumab Treatment in a Patient of Refractory Anti-EJ Positive ASyS: A Case Report. 托西珠单抗治疗难治性抗 EJ 阳性 ASyS 患者:病例报告。
IF 0.9
Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241267153
Jin Jiajia, Li Jia, Wu Wanlong, Sun Shuhui, Wang Xiaodong, Ye Shuang
{"title":"Tocilizumab Treatment in a Patient of Refractory Anti-EJ Positive ASyS: A Case Report.","authors":"Jin Jiajia, Li Jia, Wu Wanlong, Sun Shuhui, Wang Xiaodong, Ye Shuang","doi":"10.1177/23247096241267153","DOIUrl":"10.1177/23247096241267153","url":null,"abstract":"<p><p>Anti-synthetase syndrome (ASyS) is an autoimmune disease characterized by the presence of autoantibodies to aminoacyl-tRNA synthetases accompanied with various organ involvements, including the lung, joints, and skin. The ASyS-related interstitial lung disease (ILD) can be seen in the vast majority of patients. The extent of lung involvement has a significant impact on patient prognosis; the occurrence of rapid-progressive ILD could prominently increase mortality. The mainstay of treatment is prednisone in combination with conventional synthetic disease-modifying anti-rheumatic drugs or some biologic disease-modifying anti-rheumatic drugs (DMARDs). Tocilizumab (TCZ), a recombinant humanized anti-interleukin (IL)-6 receptor monoclonal antibody, has also been used to treat some systemic autoimmune rheumatic diseases associated with ILD. Although the most recent American College of Rheumatology (ACR) Guideline for the Treatment of Interstitial Lung Disease conditionally recommends against the use of TCZ as a treatment option for people with idiopathic inflammatory myopathy (IIM)-ILD progression despite initial ILD treatment, the treatment effect of TCZ in ASyS patients remains obscure, particularly for refractory cases with anti-non-Jo1 antibodies. This report describes a case of Chinese ASyS patients with anti-EJ-positive antibodies who presented with typical proximal muscle weakness, elevated creatine kinase, and ILD with non-specific interstitial pneumonia (NSIP) pattern, along with typical skin involvement such as mechanic's hand. The patients were resistant to various treatments, including rituximab (RTX), but benefited from TCZ. In this case, TCZ shows good therapeutic efficacy in a fatal acute exacerbation of ILD with a hyperinflammatory status, resulting in a relative remission of the disease flare and full preservation of lung function with a positive long-term treatment outcome.</p>","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"12 ","pages":"23247096241267153"},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11295210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A View in the Dark: Two Cases of Acute Esophageal Necrosis in the Setting of Diabetic Ketoacidosis. 黑暗中的视角:两例糖尿病酮症酸中毒急性食管坏死病例。
IF 0.9
Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241269864
Lefika Bathobakae, Rammy Bashir, Dhruv Patel, Tyler Wilkinson, Nader Mekheal, Gabriel Melki, Yana Cavanagh, Walid Baddoura
{"title":"A View in the Dark: Two Cases of Acute Esophageal Necrosis in the Setting of Diabetic Ketoacidosis.","authors":"Lefika Bathobakae, Rammy Bashir, Dhruv Patel, Tyler Wilkinson, Nader Mekheal, Gabriel Melki, Yana Cavanagh, Walid Baddoura","doi":"10.1177/23247096241269864","DOIUrl":"10.1177/23247096241269864","url":null,"abstract":"<p><p>Acute esophageal necrosis (AEN), also known as Gurvits syndrome, is a rare and potentially life-threatening condition characterized by necrosis of the esophageal mucosa. Acute esophageal necrosis is often associated with critical conditions, such as myocardial infarction, diabetic ketoacidosis (DKA), coronavirus disease 2019 (COVID-19) infection, or post-surgical complications. Patients typically present with nausea, hematemesis, acute dysphagia, and melena. Given its high mortality rate, prompt detection with upper endoscopy and early initiation of treatment are crucial. Most cases of Gurvits syndrome are managed conservatively using intravenous fluids, proton pump inhibitors, and antibiotics. Herein, we present a case series of AEN in the setting of DKA. Both patients received supportive care and were discharged in a stable condition.</p>","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"12 ","pages":"23247096241269864"},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11304478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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