Journal of investigative medicine high impact case reports最新文献_第10页

Marginal Zone Lymphoma Manifesting as Macrophage Activation Syndrome: A Case Report. 表现为巨噬细胞活化综合征的边缘区淋巴瘤：病例报告

IF 1.2

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241244732

Niloufar Ebrahimi, Sahibzadi Mahrukh Noor, Shahram Kordasti, Mojtaba Akhtari, Sayna Norouzi, Mehrbod Vakhshoori, Amir Abdipour

{"title":"Marginal Zone Lymphoma Manifesting as Macrophage Activation Syndrome: A Case Report.","authors":"Niloufar Ebrahimi, Sahibzadi Mahrukh Noor, Shahram Kordasti, Mojtaba Akhtari, Sayna Norouzi, Mehrbod Vakhshoori, Amir Abdipour","doi":"10.1177/23247096241244732","DOIUrl":"10.1177/23247096241244732","url":null,"abstract":"Macrophage activation syndrome (MAS) is a form of secondary hemophagocytic lymphohistiocytosis (HLH) when it occurs in the context of rheumatologic disorders. HLH is a rare and potentially life-threatening syndrome characterized by excessive immune system activation. It is mainly seen in children and can be genetic based or related to infections, malignancies, rheumatologic disorders, or immunodeficiency syndromes. MAS can present with nonspecific symptoms, leading to a delay in diagnosis. This report describes a case of a 64-year-old female with marginal zone lymphoma and systemic lupus erythematosus who presented with a purpuric rash and acute kidney injury. She underwent a kidney biopsy and was diagnosed with MAS. This case highlights the importance of promptly recognizing MAS's symptoms and signs, allowing timely diagnosis and early therapeutic intervention. This potentially fatal condition tends to respond well to rapid treatment initiation with corticosteroids and to address the underlying condition.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"12 ","pages":"23247096241244732"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10998482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140851407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Plasmacytoma of the Lateral Pharyngeal Wall: A Diagnostic Enigma. 咽侧壁浆细胞瘤：诊断之谜

IF 1.2

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241242237

Lefika Bathobakae, Shayee Hasan, Aneeqa Shahid, Tyler Wilkinson, Shajla Ajas, Mehandar Kumar, Sohail Qayyum, Amer Akmal

{"title":"A Plasmacytoma of the Lateral Pharyngeal Wall: A Diagnostic Enigma.","authors":"Lefika Bathobakae, Shayee Hasan, Aneeqa Shahid, Tyler Wilkinson, Shajla Ajas, Mehandar Kumar, Sohail Qayyum, Amer Akmal","doi":"10.1177/23247096241242237","DOIUrl":"10.1177/23247096241242237","url":null,"abstract":"Plasmacytoma is a rare plasma cell dyscrasia that grows in bones or soft tissues such as the pharynx. Soft tissue plasmacytomas are rare, and a higher burden has been reported in the upper aero-digestive tract, often manifesting as hoarseness, dysphagia, or odynophagia. Due to their rarity, extramedullary plasmacytomas (EMPs) have unknown prognostic factors, and guidelines for optimal management are still lacking. However, radiation therapy and surgery have been used with positive outcomes. Herein, we describe a unique case of plasmacytoma of the pharyngeal tissue in a male patient with a history of HIV disease. The patient completed 28 sessions of radiation therapy, resulting in an improvement in his throat pain and hoarseness. Given the patient's age and lack of traditional risk factors for head and neck cancers, his hoarseness and odynophagia proved to be a diagnostic conundrum. Although infrequent, soft tissue plasmacytomas should be considered in the differential diagnosis of head and neck tumors.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"12 ","pages":"23247096241242237"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10996350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140861540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-recurrent Laryngeal Nerve During Intraoperative Neuromonitoring Thyroidectomy: A Case Report and Literature Review. 术中神经监测甲状腺切除术中的非复发性喉神经：病例报告与文献综述

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241273099

Davide Inversini, Simone Gianazza, Matteo Annoni, Andrea Leotta, Dorotea Confalonieri, Enrico Ferri, Andrea Palillo, Andrea Vigezzi, Sabrina Garbarino, Giuseppe Ietto, Giulio Carcano

{"title":"Non-recurrent Laryngeal Nerve During Intraoperative Neuromonitoring Thyroidectomy: A Case Report and Literature Review.","authors":"Davide Inversini, Simone Gianazza, Matteo Annoni, Andrea Leotta, Dorotea Confalonieri, Enrico Ferri, Andrea Palillo, Andrea Vigezzi, Sabrina Garbarino, Giuseppe Ietto, Giulio Carcano","doi":"10.1177/23247096241273099","DOIUrl":"10.1177/23247096241273099","url":null,"abstract":"Complete and precise knowledge of the neck anatomy and its eventual anomalies is crucial while performing a safe thyroid and parathyroid surgery. Embryo-genetic malformations of the IV branchial arch can lead to an uncommon anatomical alteration known as non-recurrent inferior laryngeal nerve. Its prevalence varies between 0.7% for the dextral branch and 0.04% for the sinistral. In these cases, the inferior laryngeal nerve branches originate directly from the cervical vagus nerve, entering the larynx without hooking, on the right side around the subclavian artery or on the left around the aortic arch. The presence of a non-recurrent laryngeal nerve is challenging, due to the increased risks of iatrogenic damage to the nerve, which results in hoarseness, dysphagia, glottal obstruction, vocal cords palsy, and serious airway impairment. We present the case of a 58-year-old woman. The patient was admitted to our department for a nodule classified as Bethesda IV in the right thyroid lobe. Through the use of intraoperative neuromonitoring (IONM), surgeons detected intraoperatively a non-recurrent laryngeal nerve. A subsequent computed tomography scan confirmed an anomalous right subclavian artery branching from the left aortic arch, the Lusoria Artery. Anatomical variants represent pitfalls in this case and an accurate knowledge of the neck region is imperative while performing thyroid surgery. Devices such as IONM are useful for detecting abnormalities that may lead to iatrogenic damages.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"12 ","pages":"23247096241273099"},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11366100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paclitaxel-Induced Hepatotoxicity in Ovarian Cancer Patients: A Case Report. 卵巢癌患者紫杉醇诱发的肝毒性：病例报告。

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241281603

Haoran Yang, Lina Shen, Yunzhi Yang, Xiaoyu Li

{"title":"Paclitaxel-Induced Hepatotoxicity in Ovarian Cancer Patients: A Case Report.","authors":"Haoran Yang, Lina Shen, Yunzhi Yang, Xiaoyu Li","doi":"10.1177/23247096241281603","DOIUrl":"10.1177/23247096241281603","url":null,"abstract":"Paclitaxel plus carboplatin is the most common regimen for the treatment of ovarian cancer. While generally effective, these chemotherapy agents can cause adverse events such as myelotoxicity, nausea, vomiting, and rarely, hepatotoxicity. Paclitaxel is associated with mild elevations in serum aminotransferase levels, but significant hepatotoxicity is uncommon, particularly in patients without prior liver disease. We present a patient with ovarian cancer who developed significant elevation of serum aminotransferases up to 12 times the upper limit of normal after the first cycle of paclitaxel plus carboplatin chemotherapy. Extensive evaluations excluded other potential causes of liver injury and the diagnosis of paclitaxel-induced liver injury was confirmed. The patient was treated with liver protective medications and a reduced dose of paclitaxel (135 mg/m2) for subsequent cycles. Her liver function tests stabilized within 2 to 3 times the upper limit of normal, allowing continuation of chemotherapy and achieving a favorable outcome.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"12 ","pages":"23247096241281603"},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11418365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atypical Presentation of Ziprasidone-Induced Neuroleptic Malignant Syndrome: A Case Report. 齐拉西酮诱发神经性恶性综合征的非典型表现：病例报告。

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241262690

John Allonce, Sikandar Khan, Brian Pulford

{"title":"Atypical Presentation of Ziprasidone-Induced Neuroleptic Malignant Syndrome: A Case Report.","authors":"John Allonce, Sikandar Khan, Brian Pulford","doi":"10.1177/23247096241262690","DOIUrl":"10.1177/23247096241262690","url":null,"abstract":"Neuroleptic malignant syndrome (NMS) is a severe adverse reaction associated with neuroleptic or antipsychotic drugs. This case report discusses a 43-year-old man with a history of bipolar disorder and polysubstance abuse who presented with altered mental status, autonomic dysfunction, and muscular rigidity. The patient had recently started on ziprasidone, a second-generation antipsychotic, leading to an atypical presentation of NMS. Unlike classic findings associated with NMS induced by first-generation antipsychotics, this case lacked high fever, lead pipe rigidity, or elevated creatine kinase levels greater than 1000 on initial presentation. The delay in diagnosis was attributed to the milder symptoms and absence of typical findings, resulting in extensive diagnostic workup and interventions. The patient responded positively to treatment with lorazepam based on the Woodbury severity stage guidelines. This case underscores the complexity of diagnosing NMS induced by second-generation antipsychotics and highlights the need for awareness and tailored treatment approaches for atypical presentations.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"12 ","pages":"23247096241262690"},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11268033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nocardia brasiliensis Pyomyositis in an Immunocompetent Patient Following Gardening Activity. 一名免疫功能正常的患者在园艺活动后患上了巴西诺卡氏菌性肌炎。

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241261508

Aliya Rehman, Ayoola Olayiwola, Christine A Vu, Parjanya Bhatt, Joelle-Ann Joseph, Folusakin Ayoade

{"title":"Nocardia brasiliensis Pyomyositis in an Immunocompetent Patient Following Gardening Activity.","authors":"Aliya Rehman, Ayoola Olayiwola, Christine A Vu, Parjanya Bhatt, Joelle-Ann Joseph, Folusakin Ayoade","doi":"10.1177/23247096241261508","DOIUrl":"10.1177/23247096241261508","url":null,"abstract":"Nocardia pyomyositis in immunocompetent patients is a rare occurrence. The diagnosis may be missed or delayed with the risk of progressive infection and suboptimal or inappropriate treatment. We present the case of a 48-year-old immunocompetent firefighter diagnosed with pyomyositis caused by Nocardia brasiliensis acquired by direct skin inoculation from gardening activity. The patient developed a painful swelling on his right forearm that rapidly progressed proximally and deeper into the underlying muscle layer. Ultrasound imaging of his right forearm showed a 7-mm subcutaneous fluid collection with surrounding edema. Microbiologic analysis of the draining pus was confirmed to be N brasiliensis by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight (MALDI-TOF) Mass Spectrometry. After incision and drainage deep to the muscle layer to evacuate the abscess and a few ineffective antibiotic options, the patient was treated with intravenous ceftriaxone and oral linezolid for 6 weeks. He was then de-escalated to oral moxifloxacin for an additional 4 months to complete a total antibiotic treatment duration of 6 months. The wound healed satisfactorily and was completely closed by the fourth month of antibiotic therapy. Six months after discontinuation of antibiotics, the patient continued to do well with complete resolution of the infection. In this article, we discussed the risk factors for Nocardia in immunocompetent settings, the occupational risks for Nocardia in our index patient, and the challenges encountered with diagnosis and treatment. Nocardia should be included in the differential diagnosis of cutaneous infections, particularly if there is no improvement of \"cellulitis\" with traditional antimicrobial regimens and the infection extends into the deeper muscle tissues.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"12 ","pages":"23247096241261508"},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11179496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141321026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolving Endoscopic Approaches to Pancreatic Pseudocysts and Walled-Off Necrosis: Case Series and Review of Evidence. 胰腺假性囊肿和壁闭塞性坏死的内镜治疗方法：病例系列和证据回顾。

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241304521

Shivangini Duggal, Lokesh Nagineni, Bhavi S Trivedi, Marc Zuckerman, Ricardo Badillo

引用次数: 0

Rare Pulmonary MALT Lymphomas and Its Differential Diagnosis On Chest CT. 罕见肺部MALT淋巴瘤及其胸部CT鉴别诊断。

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241300918

Tongzhen Xu, Shulan Zhang, Fang Liu

引用次数: 0

Isolated Cutaneous Chronic Lymphocytic Leukemia: A Case Report. 孤立性皮肤慢性淋巴细胞白血病：病例报告

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096231204736

Zahra Kmira, Ben Ismail Hajer, Mokni Sana, Ben Sayed Nesrine, Guermazi Monia, Tabka Meriem, Chiba Dorra, Bouteraa Walid, Zaier Monia, Sriha Badreddine, Ben Youssef Yosra, Regaieg Haifa, Khelif Abderrahim

引用次数: 0

A Case of Unknown Pulmonary Nodules. 一例不明肺结节病例

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241271895

Alex Crist, Gregory Heinicke, Jasper Xi Zheng, Hanine Inaty

{"title":"A Case of Unknown Pulmonary Nodules.","authors":"Alex Crist, Gregory Heinicke, Jasper Xi Zheng, Hanine Inaty","doi":"10.1177/23247096241271895","DOIUrl":"10.1177/23247096241271895","url":null,"abstract":"A 54-year-old female with history of underlying asthma and 10 pack-year smoking history was seen in interventional pulmonology clinic for evaluation of multiple scattered pulmonary nodules incidentally found on chest computed tomography (CT). Given the central location of the dominant left upper lobe (LUL) nodule and its proximity to an airway, bronchoscopic biopsy was felt to be the right approach. The IonTM Endoluminal System robotic-assisted navigational bronchoscope (Intuitive Surgical, Sunnyvale, California) was used to sample the LUL nodule under fluoroscopic guidance. Together with clinical and radiological findings, the histological and immunophenotypic findings are supportive for Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH). The DIPNECH is a rare condition first described in a case series published in cancer in 1953. This highly atypical condition highlights the utility of modern navigational bronchoscopy in safely securing a diagnostic bronchoscopic biopsy in locations not previously reachable. This is especially relevant given the challenge and risk to percutaneous CT-guided biopsy. Complications are known to scale with depth from skin site, emphasizing benefits of the bronchoscopic approach in obese patients.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"12 ","pages":"23247096241271895"},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11489905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0