Journal of investigative medicine high impact case reports最新文献_第2页

Clostridium paraputrificum in a Middle-Aged Male With Liver Disease. 一名患有肝病的中年男性体内的副猪梭状芽孢杆菌

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241292213

Kevin Trong Dao, Carlos D'Assumpcao, Rupam Sharma, Arash Heidari

引用次数: 0

Usage of Padlock Over-the-Scope-Clip in Difficult-to-Control Recurrent Gastrointestinal Bleeding Due to a Gastric Dieulafoy Lesion. 在胃蝶鞍病变导致的难以控制的复发性消化道出血中使用挂锁式蝶鞍夹。

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241263062

John Joyce, Vishnu Kumar, Dayana Nasr, Ganesh Aswath, Hafiz M Khan, Savio John

引用次数: 0

A Rare Case of Anti-TIF-1γ Antibody Positive Dermatomyositis in Adulthood. 一例罕见的成年期抗 TIF-1γ 抗体阳性皮肌炎病例

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241263065

Upasana Agrawal, Manush Sondhi, Alexandra Zamora Smith, Syeda Sara Nida, Sarwat Umer, Samina Hayat, Kinza Muzaffar

引用次数: 0

Complete Pathologic Response With Pembrolizumab and Enfortumab Vedotin in Urothelial Carcinoma of the Upper Urinary Tract. 使用 Pembrolizumab 和 Enfortumab Vedotin 治疗上尿路上皮癌的完全病理反应

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241257333

Kok Hoe Chan, Tung Shu, Majd Al Shaarani, Putao Cen

{"title":"Complete Pathologic Response With Pembrolizumab and Enfortumab Vedotin in Urothelial Carcinoma of the Upper Urinary Tract.","authors":"Kok Hoe Chan, Tung Shu, Majd Al Shaarani, Putao Cen","doi":"10.1177/23247096241257333","DOIUrl":"10.1177/23247096241257333","url":null,"abstract":"Urothelial carcinoma of the upper urinary tract (UTUC) presents a significant clinical challenge, often requiring aggressive surgical intervention for optimal management. We present a case of an 84-year-old woman with recurrent high-grade papillary UTUC of the left renal pelvis, refractory to prior endourologic interventions, who underwent neoadjuvant treatment with pembrolizumab and enfortumab vedotin (Pembro/EV) due to contraindications to cisplatin therapy. Following a favorable response to neoadjuvant therapy, the patient underwent laparoscopic left radical nephroureterectomy, achieving a pathologic complete response. We discuss the utility of Pembro/EV in the perioperative management of patients with UTUC, particularly in those ineligible for cisplatin-based therapy. In addition, we highlight the potential role of somatic mutation testing and the integration of novel therapeutic agents such as olaparib in personalized treatment strategies for UTUC. This case underscores the importance of exploring innovative treatment approaches and optimizing patient selection for kidney preservation strategies in the management of UTUC. Further research and clinical trials are warranted to elucidate the full therapeutic potential of Pembro/EV and other emerging therapies in this setting.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141158098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tocilizumab Treatment in a Patient of Refractory Anti-EJ Positive ASyS: A Case Report. 托西珠单抗治疗难治性抗 EJ 阳性 ASyS 患者：病例报告。

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241267153

Jin Jiajia, Li Jia, Wu Wanlong, Sun Shuhui, Wang Xiaodong, Ye Shuang

{"title":"Tocilizumab Treatment in a Patient of Refractory Anti-EJ Positive ASyS: A Case Report.","authors":"Jin Jiajia, Li Jia, Wu Wanlong, Sun Shuhui, Wang Xiaodong, Ye Shuang","doi":"10.1177/23247096241267153","DOIUrl":"10.1177/23247096241267153","url":null,"abstract":"Anti-synthetase syndrome (ASyS) is an autoimmune disease characterized by the presence of autoantibodies to aminoacyl-tRNA synthetases accompanied with various organ involvements, including the lung, joints, and skin. The ASyS-related interstitial lung disease (ILD) can be seen in the vast majority of patients. The extent of lung involvement has a significant impact on patient prognosis; the occurrence of rapid-progressive ILD could prominently increase mortality. The mainstay of treatment is prednisone in combination with conventional synthetic disease-modifying anti-rheumatic drugs or some biologic disease-modifying anti-rheumatic drugs (DMARDs). Tocilizumab (TCZ), a recombinant humanized anti-interleukin (IL)-6 receptor monoclonal antibody, has also been used to treat some systemic autoimmune rheumatic diseases associated with ILD. Although the most recent American College of Rheumatology (ACR) Guideline for the Treatment of Interstitial Lung Disease conditionally recommends against the use of TCZ as a treatment option for people with idiopathic inflammatory myopathy (IIM)-ILD progression despite initial ILD treatment, the treatment effect of TCZ in ASyS patients remains obscure, particularly for refractory cases with anti-non-Jo1 antibodies. This report describes a case of Chinese ASyS patients with anti-EJ-positive antibodies who presented with typical proximal muscle weakness, elevated creatine kinase, and ILD with non-specific interstitial pneumonia (NSIP) pattern, along with typical skin involvement such as mechanic's hand. The patients were resistant to various treatments, including rituximab (RTX), but benefited from TCZ. In this case, TCZ shows good therapeutic efficacy in a fatal acute exacerbation of ILD with a hyperinflammatory status, resulting in a relative remission of the disease flare and full preservation of lung function with a positive long-term treatment outcome.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11295210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Vulvovaginal Yeast Infection Caused by Cryptococcus victoriae in Vietnam: A Rare Case Report. 越南一例由胜利隐球菌引起的外阴酵母菌感染：罕见病例报告。

IF 1.2

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241237756

Hoang Dinh Canh, Cao Ba Loi, Dao Nguyen Hung, Le Thi Hong Van, Nguyen Thi Nhu Quynh, Do Thi Thuy Dung, Nguyen Ngoc Tuan, Do Ngoc Anh

{"title":"A Vulvovaginal Yeast Infection Caused by Cryptococcus victoriae in Vietnam: A Rare Case Report.","authors":"Hoang Dinh Canh, Cao Ba Loi, Dao Nguyen Hung, Le Thi Hong Van, Nguyen Thi Nhu Quynh, Do Thi Thuy Dung, Nguyen Ngoc Tuan, Do Ngoc Anh","doi":"10.1177/23247096241237756","DOIUrl":"10.1177/23247096241237756","url":null,"abstract":"Cases of vulvovaginitis caused by Cryptococcus genus are exceedingly uncommon, with only a handful of instances having been described for this causative species. This report describes a rare case of vulvovaginitis suspected to be caused by Cryptococcus victoriae in a 58-year-old woman residing in an urban area of Hanoi city, Vietnam. The patient with a 10-year history of depression and type 2 diabetes mellitus was admitted to the hospital due to vulvar itching and vaginal discharge. Vaginal swabs confirmed the presence of a yeast infection by direct microscopic examination with 10% KOH and culture on CHROMagar Candida. The yeast was identified as C victoriae using genetic sequencing tools. The patient's treatment plan involved topical clotrimazole and a daily oral dose of 200 mg of itraconazole for 7 days. This comprehensive treatment approach resulted in the patient's full recovery. This is the first reported case of vulvovaginitis attributed to C victoriae in humans worldwide.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10929040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140094204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gastroduodenal Involvement in AL Amyloidosis: Case Report and Literature Review. AL 淀粉样变性的胃十二指肠受累：病例报告与文献综述

IF 1.2

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241237759

Rajarajeshwari Ramachandran, Tyler Grantham, Giovannie Isaac-Coss, Denzil Etienne, Madhavi Reddy

{"title":"Gastroduodenal Involvement in AL Amyloidosis: Case Report and Literature Review.","authors":"Rajarajeshwari Ramachandran, Tyler Grantham, Giovannie Isaac-Coss, Denzil Etienne, Madhavi Reddy","doi":"10.1177/23247096241237759","DOIUrl":"10.1177/23247096241237759","url":null,"abstract":"Gastrointestinal amyloidosis is a rare condition commonly found in the setting of systemic AL amyloidosis. Amyloid can deposit throughout the gastrointestinal tract and the resulting symptoms vary depending on the site of deposition. Gastrointestinal (GI) manifestations can range from weight loss or abdominal pain, to more serious complications like gastrointestinal bleeding, malabsorption, dysmotility, and obstruction. This case describes a patient with known history of IgG lambda AL amyloidosis, presenting with epigastric pain and unintentional weight loss found to have gastroduodenal amyloidosis. The definitive diagnosis of GI amyloidosis requires endoscopic biopsy with Congo red staining and visualization under polarized light microscopy. There are currently no specific guidelines for the management of GI amyloidosis. Generally, the goal is to treat the underlying cause of the amyloidosis along with symptom management. Our patient is being treated with cyclophosphamide, bortezomib, and dexamethasone (CyBorD) and started on hemodialysis due to progression of renal disease.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10929022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140094205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hantavirus Cardiopulmonary syndrome: Another Reason to Avoid Mice. 汉坦病毒心肺综合征：避免接触小鼠的另一个原因

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241274572

Mark Kennedy, Omar Mctabi, Christopher Rickman

引用次数: 0

Is There a Baby in the Lung? A Case of Placental Transmogrification of the Lung. 肺里有婴儿吗？一例胎盘肺变性病例。

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241261322

Mohammad Abdulelah, Nicole Kasher, Gabriella Primera, Jessika Matta, Ruchi Patel, Karim Anis, Ernest DiNino

引用次数: 0

Cefepime Neurotoxicity in Patients With Normal Renal Function: An Overlooked Cause of Encephalopathy in the Intensive Care Unit. 肾功能正常患者的头孢吡肟神经毒性：重症监护病房脑病的一个被忽视的原因。

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241259534

Zakaria Alagha, Samuel Crow, Abdul Muhsen Z Abdeen, Maha Alastal, Amro Alastal

引用次数: 0