Journal of investigative medicine high impact case reports最新文献_第2页

Successful Endoscopic Management of Oxyntic Gland Adenoma: A Case Report. 内镜下成功治疗氧合腺腺瘤1例。

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Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 DOI: 10.1177/23247096251313729

Rajarajeshwari Ramachandran, Tyler Grantham, Jeffrey Loeffler, Madhavi Reddy, Vinaya Gaduputi

引用次数: 0

Lymphocytic Esophagitis: Navigating an Uncharted Territory. 淋巴细胞性食管炎：探索未知领域。

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Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 DOI: 10.1177/23247096251313734

Ahmad Jradi, Kaline Maya Khoury, Karam Karam, Dr Ihab I El Hajj, Elias Fiani

{"title":"Lymphocytic Esophagitis: Navigating an Uncharted Territory.","authors":"Ahmad Jradi, Kaline Maya Khoury, Karam Karam, Dr Ihab I El Hajj, Elias Fiani","doi":"10.1177/23247096251313734","DOIUrl":"10.1177/23247096251313734","url":null,"abstract":"Lymphocytic esophagitis (LE) is an uncommon subtype of esophagitis defined by persistent esophageal inflammation characterized by a high count of intraepithelial lymphocytes with scarce granulocytes. Although LE can present with atypical features such as chest pain, its clinical presentation can mimic that of gastroesophageal reflux disease or eosinophilic esophagitis, highlighting the importance of biopsy in diagnosing LE. Studies are still limited in understanding the pathophysiology behind this disease warranting further research. A 47-year-old female patient sought medical care with a chief complaint of recurrent substernal chest pain for the past year. An esophagogastroduodenoscopy was performed and showed patchy linear esophageal erosions and mucosal edema in the middle third of the esophagus with mild erythema. Biopsies revealed intraepithelial lymphocytosis with more than 40 lymphocytes per high-power field, corroborating a diagnosis of LE. Patient reported improvement after receiving high dose of proton pump inhibitor (PPI) on her first follow-up, advised to follow a low-acid diet and an annual endoscopy to monitor her response to treatment. Lymphocytic esophagitis often presents with symptoms that overlap with other esophageal diseases explaining the possible errors in underdiagnosing it as reason behind non-cardiac chest pain. This case plays an instrumental role in changing the way physicians translate unexplained chest pain, adding LE to their list of differential diagnosis as prompt detection slows us to start management with PPIs quicker and lessen the burden of symptoms on the patient. Standardized treatment approaches and further studies are required to clarify the connection between LE and non-cardiac chest discomfort.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"13 ","pages":"23247096251313734"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Idiopathic Nodular Glomerulosclerosis in a Long-term Passive Smoker With Recently Diagnosed Hypertension: A Case Report. 长期被动吸烟者新近诊断为高血压的特发性结节性肾小球硬化1例报告。

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Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-03-11 DOI: 10.1177/23247096251323066

Mehrbod Vakhshoori, Paul E Hanna, Zainab Obaidi, Yan Chen Wongworawat, Amir Abdipour, Sayna Norouzi

{"title":"Idiopathic Nodular Glomerulosclerosis in a Long-term Passive Smoker With Recently Diagnosed Hypertension: A Case Report.","authors":"Mehrbod Vakhshoori, Paul E Hanna, Zainab Obaidi, Yan Chen Wongworawat, Amir Abdipour, Sayna Norouzi","doi":"10.1177/23247096251323066","DOIUrl":"10.1177/23247096251323066","url":null,"abstract":"Idiopathic nodular glomerulosclerosis (ING) is mostly associated with long-standing active smoking and hypertension (HTN). Herein, we present a rare case of ING in a passive smoker with recently diagnosed uncontrolled HTN. A 60-year-old white female with Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal plasma cell disorder, Skin changes (POEMS) syndrome and newly diagnosed HTN was referred because of an elevated creatinine level. She denied being an active smoker but reported long-term exposure to cigarette smoke due to living with a heavy smoking family and working as a bartender. Further investigations revealed microscopic hematuria and nephritic range proteinuria. Kidney biopsy revealed diffuse and focal nodular mesangial expansion without hypercellularity, with negative staining for amyloid, fibrillary glomerulonephritis, and immunoglobulins, leading to a diagnosis of ING. This case highlights a rare case of ING secondary to heavy passive smoking and uncontrolled HTN.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"13 ","pages":"23247096251323066"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11898078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Asymptomatic Isolated Congenitally Corrected Transposition of the Great Arteries in a 25-Year-Old Male: A Case Report. 25岁男性无症状孤立性先天性纠正大动脉转位1例报告。

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Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-05-08 DOI: 10.1177/23247096251331840

Ahmed Aldolly, Saja Karaja, Hazem Arab, Yousef Alsaffaf, Saleh Takkem

{"title":"Asymptomatic Isolated Congenitally Corrected Transposition of the Great Arteries in a 25-Year-Old Male: A Case Report.","authors":"Ahmed Aldolly, Saja Karaja, Hazem Arab, Yousef Alsaffaf, Saleh Takkem","doi":"10.1177/23247096251331840","DOIUrl":"https://doi.org/10.1177/23247096251331840","url":null,"abstract":"Congenitally corrected transposition of the great arteries (ccTGA) is a complex cardiac abnormality that represents less than 1% of all congenital heart defects. It is characterized by a unique pathophysiology involving both atrioventricular and ventriculoarterial discordance and may occur with or without cardiac abnormalities such as ventricular septal defects, pulmonary stenosis, or tricuspid valve anomalies. A man in his 20s presented with a 3-week history of mild dyspnea during strenuous activities. The patient was diagnosed with isolated ccTGA based on electrocardiogram and echocardiogram findings. However, as a long-term complication of ccTGA, the patient exhibited mild tricuspid regurgitation, mild mitral regurgitation, and right ventricular hypertrophy. The dyspnea was explained by the failing systemic right ventricle. Despite his cardiac anomaly, the patient leads a normal lifestyle, with ongoing monitoring to ensure optimal management of his condition. ccTGA is even rarer in the absence of additional cardiac abnormalities, and its diagnosis could be delayed due to being asymptomatic. Patients must avoid risk factors and that could potentially aggravate their condition. Regular surveillance is imperative for the early detection of potential complications.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"13 ","pages":"23247096251331840"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complement-Mediated Hemolytic Uremic Syndrome Due to MCP/CD46 Mutation: A Case Report. MCP/CD46突变引起的补体介导的溶血性尿毒症综合征1例报告

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Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 DOI: 10.1177/23247096251316364

Abdul Muhsen Abdeen, Jowan Al-Nusair, Malik Samardali, Mohamed Alshal, Amro Al-Astal, Zeid Khitan

{"title":"Complement-Mediated Hemolytic Uremic Syndrome Due to MCP/CD46 Mutation: A Case Report.","authors":"Abdul Muhsen Abdeen, Jowan Al-Nusair, Malik Samardali, Mohamed Alshal, Amro Al-Astal, Zeid Khitan","doi":"10.1177/23247096251316364","DOIUrl":"10.1177/23247096251316364","url":null,"abstract":"Thrombotic microangiopathy (TMA) is a severe condition characterized by microangiopathic hemolytic anemia, thrombocytopenia, and end-organ damage, often involving the kidneys. Complement-mediated hemolytic uremic syndrome (cHUS), a rare form of TMA, arises from dysregulated alternative complement pathway activation, frequently due to genetic mutations. We report the case of a 23-year-old male presenting with TMA secondary to a heterozygous mutation in the membrane cofactor protein (MCP/CD46) gene. The patient exhibited severe renal and cardiovascular complications, including acute kidney injury requiring hemodialysis, uremic pericarditis, and persistent anemia. Diagnostic evaluation confirmed complement dysregulation, and management with eculizumab, plasmapheresis, and hemodialysis was initiated. Renal biopsy revealed classic TMA features, and genetic testing identified the MCP mutation, underscoring the importance of genetic predispositions in guiding diagnosis and therapy. This case emphasizes the critical role of genetic testing in TMA evaluation and highlights the potential for improved outcomes through targeted complement inhibition and individualized care strategies.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"13 ","pages":"23247096251316364"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blastoid Mantle Cell Lymphoma Presenting as an Isolated Cecal Mass. 囊胚套细胞淋巴瘤表现为孤立的盲肠肿块。

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Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-03-17 DOI: 10.1177/23247096251325401

Lefika Bathobakae, Jorge L Lopez Cuello, Rammy Bashir, Heba Farhan, Irhoboudu D Atogwe, Yana Cavanagh

{"title":"Blastoid Mantle Cell Lymphoma Presenting as an Isolated Cecal Mass.","authors":"Lefika Bathobakae, Jorge L Lopez Cuello, Rammy Bashir, Heba Farhan, Irhoboudu D Atogwe, Yana Cavanagh","doi":"10.1177/23247096251325401","DOIUrl":"10.1177/23247096251325401","url":null,"abstract":"Blastoid mantle cell lymphoma (B-MCL) is a rare and aggressive subtype of B-cell non-Hodgkin lymphoma characterized by a high proliferation index and poor prognosis. Gastrointestinal (GI) involvement, which is common in systemic mantle cell lymphoma (MCL), rarely presents as an isolated lesion. Herein, we describe a unique case of B-MCL presenting as an isolated cecal mass. The patient experienced acute-onset abdominal pain and melena and was found to have cecal wall thickening on imaging, with regional lymphadenopathy. Colonoscopy revealed a large ulcerated polypoid lesion in the cecum, and histopathology confirmed the diagnosis of B-MCL. The patient completed 4 cycles of bendamustine/rituximab regimen but was terminally extubated due to clinical deterioration. Although infrequent, MCL should be considered in the differential diagnosis of isolated GI masses. This case adds to the limited literature on B-MCL, which could potentially help with the formulation of diagnostic and treatment algorithms for this rare pathology.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"13 ","pages":"23247096251325401"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11915275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Scleroderma Renal Crisis. 罕见硬皮病肾危象1例。

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Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-04-25 DOI: 10.1177/23247096251336565

Ariel Ahl, Harendra Ipalawatte, Saif Ghias, Arian Gower

{"title":"A Rare Case of Scleroderma Renal Crisis.","authors":"Ariel Ahl, Harendra Ipalawatte, Saif Ghias, Arian Gower","doi":"10.1177/23247096251336565","DOIUrl":"https://doi.org/10.1177/23247096251336565","url":null,"abstract":"Scleroderma renal crisis is a rare, life-threatening complication of systemic sclerosis. It is characterized by pronounced hypertension, acute kidney injury, and thrombotic microangiopathy. Although its prevalence has decreased over the last decade, and death rates have declined since the introduction of treatment with Angiotensin converting enzyme (ACE)-inhibitors, it remains a challenge due to lack of prevention and rapid progression despite intervention in those who develop renal crisis. We present a 46-year-old female with history of rheumatoid arthritis and scleroderma who presented to the Emergency Department (ED) with complaints of a severe headache associated with nausea and vomiting that started earlier in the day. Patient presented with a blood pressure of 180/103 that did not improve with use of anti-hypertensive medications. Labs were remarkable for anemia and decreased renal function. A CT of the abdomen and pelvis without contrast demonstrated distention of distal esophagus with possible underlying esophageal dysmotility due to degree of distention and dependent areas of tractional bronchiectasis in the bilateral lower lobes that can be seen in the setting of early interstitial lung disease. Treatment with an ACE-inhibitor was initiated, with improvement in blood pressure and resolution of headache. This case demonstrates another rare case and illustrates the importance of rapid recognition and treatment.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"13 ","pages":"23247096251336565"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Giant Right Atrial Myxoma Presenting With Right Heart Failure. 巨大右心房黏液瘤表现为右心衰。

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Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-03-27 DOI: 10.1177/23247096251329706

Priya Ramcharan, Arun Katwaroo, Matthew Maharaj, Valmiki Seecheran, Dayna Lalchansingh, Rajeev Seecheran, Shari Khan, Naveen Seecheran

引用次数: 0

A Case of Tuberculous Meningitis With Concomitant Spinal Co-infection With Tuberculosis and Aspergillosis. 结核性脑膜炎合并脊柱结核和曲霉病感染1例。

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Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-03-26 DOI: 10.1177/23247096251329684

Candice A Sternberg, Andres Martinez, Ayoola Olayiwola, Maria Morel Almonte, Christine A Vu, Tanya Quiroz, Nadine Montreuil, Folusakin Ayoade

{"title":"A Case of Tuberculous Meningitis With Concomitant Spinal Co-infection With Tuberculosis and Aspergillosis.","authors":"Candice A Sternberg, Andres Martinez, Ayoola Olayiwola, Maria Morel Almonte, Christine A Vu, Tanya Quiroz, Nadine Montreuil, Folusakin Ayoade","doi":"10.1177/23247096251329684","DOIUrl":"10.1177/23247096251329684","url":null,"abstract":"Co-infection with Mycobacterium tuberculosis and Aspergillus in an immunocompetent host is rare but can occur. In this case, we present a patient with central nervous system tuberculosis (TB) and biopsy-proven spinal co-infections with TB and Aspergillosis. We highlight the complexities of treating a TB-Aspergillosis co-infection given drug-drug interactions between standard therapy for both conditions. Using susceptibilities for the Aspergillus and carefully monitoring drug levels of the antifungal agents, we were able to optimally treat the co-infection. This patient was ultimately discharged on isoniazid 1200 mg (15 mg/kg) daily, levofloxacin 750 mg daily, rifabutin 450 mg daily, and posaconazole 300 mg twice daily with a tentative plan to treat for at least 1 year with close outpatient follow-up. This case can serve as a guide for other providers who need to treat cases of TB and Aspergillosis co-infection by learning from our experience and paying attention to potential pitfalls.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"13 ","pages":"23247096251329684"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thanks to Reviewers. 感谢审稿人。

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Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 DOI: 10.1177/23247096251316453

引用次数: 0