Journal of investigative medicine high impact case reports最新文献_第3页

Abdominal Actinomycosis Abscess Mimicking Malignancy: A Case Report and Review of the Literature. 腹部模拟恶性脓肿放线菌病1例报告及文献复习。

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Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 DOI: 10.1177/23247096251316374

Yosra Loukil, Saadia Makni, Youssef Mejdoub, Haitham Rejab, Nozha Toumi, Slim Charfi, Tahya Sallemi Boudawara, Marwa Bouhamed

引用次数: 0

Unveiling Rare Pulmonary Complications in Infective Endocarditis: Pneumatoceles and Pneumothorax in a Case Series With Contextual Literature Review. 揭示感染性心内膜炎的罕见肺部并发症：气肿和气胸的病例系列与相关文献回顾。

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Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-04-11 DOI: 10.1177/23247096251334228

Nagihan Orhun, Islam Rajab, Utku Ekin, George Horani, Mourad Ismail

引用次数: 0

Unveiling the Link Between Breast Cancer and Liver Abscess: A Case Report and Review of Literature. 揭示乳腺癌与肝脓肿的关系：1例报告及文献复习。

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Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-04-12 DOI: 10.1177/23247096251334232

Jayalekshmi Jayakumar, Manasa Ginjupalli, Giovannie Isaac Coss, Fiqe Khan, Daniel Stein, Davin Turku, Khalimullah Quadri

{"title":"Unveiling the Link Between Breast Cancer and Liver Abscess: A Case Report and Review of Literature.","authors":"Jayalekshmi Jayakumar, Manasa Ginjupalli, Giovannie Isaac Coss, Fiqe Khan, Daniel Stein, Davin Turku, Khalimullah Quadri","doi":"10.1177/23247096251334232","DOIUrl":"https://doi.org/10.1177/23247096251334232","url":null,"abstract":"The introduction of screening mammograms has revolutionized the early detection of breast cancer. However, it remains the most common cancer in women in the United States, excluding skin cancer. As the incidence rates continue to rise, unusual presentations have become more frequent. Additionally, healthcare barriers can lead to delayed detection of breast cancer, resulting in unexpected complications. The occurrence of pyogenic liver abscess (PLA) in diabetic cancer patients, due to the synergistic effect of insulin-like growth factor-1 in tumorigenesis and abscess formation, is well documented. PLA is also prevalent in hepatocellular, colorectal, and pancreato-biliary tumors. However, the occurrence of PLA as an initial presentation of isolated advanced breast cancer without these comorbidities is understudied. This may be due to direct spread of infection from affected skin or spread via lymphatics or vasculature in the setting of immunosuppression from cancer. We present an exceedingly rare case of PLA, complicated by pulmonary embolism, in an elderly female with newly diagnosed stage IIIB breast carcinoma.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"13 ","pages":"23247096251334232"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Extubation Readiness in Guillain-Barré Syndrome: A Case Report and Literature Review. 探讨格林-巴勒综合征的拔管准备情况：1例报告和文献复习。

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Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-05-08 DOI: 10.1177/23247096251331859

Victoria Watson, Saif Ghishan, Tata Avalishvili, Sinen Zeleke, Saron Tigabe, Anderson White, Fuad Zeid, Zakaria Alagha

{"title":"Exploring Extubation Readiness in Guillain-Barré Syndrome: A Case Report and Literature Review.","authors":"Victoria Watson, Saif Ghishan, Tata Avalishvili, Sinen Zeleke, Saron Tigabe, Anderson White, Fuad Zeid, Zakaria Alagha","doi":"10.1177/23247096251331859","DOIUrl":"https://doi.org/10.1177/23247096251331859","url":null,"abstract":"Guillain-Barré Syndrome (GBS) is an acute immune-mediated polyneuropathy causing rapidly progressive muscle weakness and often respiratory failure, requiring mechanical ventilation in 30% of cases. Successful weaning and extubation are crucial, focusing on readiness for spontaneous breathing trials, optimal timing, and minimizing complications such as ventilator-associated pneumonia and extubation failure. This case report describes an 83-year-old male with multiple comorbidities who was intubated after his negative inspiratory force dropped below -30 cm H₂O and treated with plasmapheresis, leading to partial improvement. Despite not meeting standard extubation criteria, he was successfully extubated, maintained stable respiratory function, and was safely discharged. This case highlights the challenges of extubation in GBS patients, where advanced age, decreased physiological reserve, and comorbidities increase the risks of prolonged intubation and complications. This case also highlights the need for individualized extubation strategies in GBS, particularly in elderly patients who may not meet standard criteria. Tailored approaches can still lead to successful outcomes. Based on our institutional experience, we propose factors that predict the success or failure of extubation in these patients. Further research is needed to refine predictive markers and improve extubation success in this population, ultimately enhancing outcomes and reducing ICU and hospital stays.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"13 ","pages":"23247096251331859"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Pulmonary Sarcoidosis With Multiple Endobronchial Polypoid Structures and Partial Airway Obstruction. 肺结节病合并多发性支气管内息肉样结构及部分气道阻塞1例。

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Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 DOI: 10.1177/23247096251313630

Nagihan Orhun, Utku Ekin, Islam Rajab, Jessimar Sanchez, Arham Hazari, Mourad Ismail

引用次数: 0

Rising Into Relevance: A Rare Case of Saccharomyces cerevisiae Pyelonephritis in an Immunosuppressed Patient With Exposure to Sourdough Starter. 越来越重要：一例暴露于酵母发酵剂的免疫抑制患者的酿酒酵母肾盂肾炎。

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Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 DOI: 10.1177/23247096251322284

Alissa Mingo, Drew Stone, Andrew D Schreiner, Richard Lueking

{"title":"Rising Into Relevance: A Rare Case of Saccharomyces cerevisiae Pyelonephritis in an Immunosuppressed Patient With Exposure to Sourdough Starter.","authors":"Alissa Mingo, Drew Stone, Andrew D Schreiner, Richard Lueking","doi":"10.1177/23247096251322284","DOIUrl":"10.1177/23247096251322284","url":null,"abstract":"Saccharomyces cerevisiae, commonly known as Baker's yeast, has been used in breadmaking, winemaking, and beer brewing for centuries. Although not generally regarded as pathogenic, rare cases of invasive infections have occurred in patients predisposed by critical illness, immunosuppression, or prolonged antibiotic use. Using data collected from the electronic medical record and personal interactions with the patient, we present a case of complicated S cerevisiae urinary tract infection (UTI). We searched terms (and permutations of terms) including Saccharomyces cerevisiae, Baker's or Brewer's yeast, and urinary tract infection using PubMed to identify previously published evidence of invasive S cerevisiae infections. Our patient is a 30-year-old woman with a history of rheumatoid arthritis on methotrexate, and previous admission for Candida glabrata UTI requiring intravenous antifungal therapies, who presented to her gynecologist with complaints of vaginitis and flank pain. Vaginal and urine cultures grew S cerevisiae, and the patient was diagnosed with pyelonephritis and admitted for treatment. A further review of the patient's history revealed daily exposure to S cerevisiae through baking sourdough bread. She was treated with 7 days of IV amphotericin deoxycholate and discharged on a 6-month course of suppressive oteseconazole for vulvovaginitis suppression. Saccharomyces cerevisiae is an exceedingly rare cause of invasive fungal UTI, with our literature review identifying only a few case reports of associated UTI and fungemia, all related to probiotic use. Our case emphasizes the importance of careful history taking and early diagnostic cultures in those at risk of invasive fungal infections.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"13 ","pages":"23247096251322284"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11851732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methimazole-Induced Cholestatic Jaundice: A Rare Case and Literature Review. 甲巯咪唑致胆汁淤积性黄疸1例及文献复习。

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Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 DOI: 10.1177/23247096251317285

Ahmed Mohamed Nefzi, Dhouha Cherif, Habiba Dabbebi, Haythem Yacoub, Hajer Hassine, Hela Kchir, Khadija Bellil, Nadia Maamouri

{"title":"Methimazole-Induced Cholestatic Jaundice: A Rare Case and Literature Review.","authors":"Ahmed Mohamed Nefzi, Dhouha Cherif, Habiba Dabbebi, Haythem Yacoub, Hajer Hassine, Hela Kchir, Khadija Bellil, Nadia Maamouri","doi":"10.1177/23247096251317285","DOIUrl":"10.1177/23247096251317285","url":null,"abstract":"Methimazole is commonly prescribed for patients with hyperthyroidism. It typically exhibits a well-tolerated profile, with common side effects including gastrointestinal disorders and rash. However, more serious rare yet adverse reactions, notably agranulocytosis and hepatotoxicity have been documented in literature. Here we present a case of a 27-year-old female, recently diagnosed with Graves' disease, who was prescribed methimazole and developed severe pruritus with cholestatic jaundice 13 days later. Concomitant causes of liver disease were ruled out. The treatment was discontinued, and a switch to corticosteroid therapy with a regimen of radioactive iodine sessions was initiated. The patient's condition showed a resolution of pruritus and jaundice, a disappearance of cytolysis with an aggravation of cholestasis followed by a gradual decrease, leading to the liver function normalization after 2 years. Methimazole-induced cholestatic jaundice is a rare yet severe adverse effect. Patients should be aware of this complication and advised to immediately stop taking the treatment when suggestive symptoms (pruritus, jaundice, dark urine, light-colored stool) occur.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"13 ","pages":"23247096251317285"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11800239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel SPAST Deletion Mutation in an American Family With Hereditary Spastic Paraplegia: A Case Report. 一个美国家族遗传性痉挛性截瘫患者的新型SPAST缺失突变：一例报告。

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Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 DOI: 10.1177/23247096251323173

Sydney B Bhopatkar, Juebin Huang

{"title":"Novel SPAST Deletion Mutation in an American Family With Hereditary Spastic Paraplegia: A Case Report.","authors":"Sydney B Bhopatkar, Juebin Huang","doi":"10.1177/23247096251323173","DOIUrl":"10.1177/23247096251323173","url":null,"abstract":"The diverse group of neurodegenerative disorders known as hereditary spastic paraplegia (HSP) is characterized by spasticity and weakness of the bilateral lower extremity due to degeneration of the corticospinal tract. The pathogenesis of HSP is broad, with autosomal dominant, autosomal recessive, X-linked recessive, mitochondrial inheritance, and de novo mutations reported, along with remarkable heterogeneity of mutations and clinical presentation. Of these, the most common subtype of HSP is HSP type 4 (HSP-SPG4), a result of mutations in the SPAST gene (chromosome 2p22.3) that leads to impaired activity of the microtubule-severing protein spastin. Typically presenting as an uncomplicated, autosomal dominant form of the disease, HSP-SPG4 has been documented worldwide with vast genomic variance across the SPAST gene. Despite common features in clinical phenotypes, a clear link between SPAST gene variants and disease presentation remains vague. Here, we report a novel 26.1 kb deletion in the SPAST gene (del exons 4-7) in a US family with previously undiagnosed HSP-SPG4.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"13 ","pages":"23247096251323173"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sarcoidosis Presenting as a Giant Pulmonary Bulla With Concurrent COVID-19 Infection. 结节病表现为巨大肺大泡并并发COVID-19感染。

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Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-05-08 DOI: 10.1177/23247096251340738

Sathish Krishnan, Anam Naumaan, Venu Pararath Gopalakrishnan

引用次数: 0

Unmasking Cystic Fibrosis in Adulthood, a Case Report. 揭露成年期囊性纤维化，一例报告。

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Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-04-11 DOI: 10.1177/23247096251334248

Malina Mohtadi, Ruba Habib, Abraam Rezkalla, George Horani, Radhika Tailor, Patrick Michael

引用次数: 0