HE-4 in the Diagnosis of Carcinoma of Ovary Presented as Unknown primary Carcinoma: A Case Report.

IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL

Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-06-18 DOI:10.1177/23247096251344701

Shengmin Huang, Muhammad Tahir, Gardith Joseph, Richrd Wu, Jaron Tepper, Jen C Wang

引用次数: 0

Abstract

Ovarian cancer is the second most common gynecologic malignancy in the United States, with high mortality due to delayed diagnosis. Serum CA-125 is widely used for screening and monitoring but lacks sensitivity and specificity in some cases. We present a 67-year-old female diagnosed with advanced-stage ovarian cancer despite normal CA-125 levels, with elevated HE4 (human epididymis protein 4), underscoring its diagnostic value. This case highlights the importance of integrating HE4 with CA-125 in ovarian cancer evaluation and emphasizes a multimodal approach to enhance early detection and outcomes.

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HE-4在原发性未知卵巢癌中的诊断价值1例。

卵巢癌是美国第二大常见的妇科恶性肿瘤，由于诊断延迟，死亡率很高。血清CA-125广泛用于筛查和监测，但在某些情况下缺乏敏感性和特异性。我们报告了一位67岁的女性，尽管CA-125水平正常，但被诊断为晚期卵巢癌，HE4（人附睾蛋白4）升高，强调了其诊断价值。本病例强调了将HE4和CA-125结合在卵巢癌评估中的重要性，并强调了采用多模式方法来提高早期发现和预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of investigative medicine high impact case reports MEDICINE, GENERAL & INTERNAL-

CiteScore

1.90

自引率

0.00%

发文量

165

审稿时长

12 weeks

期刊介绍： The AFMR is committed to enhancing the training and career development of our members and to furthering its mission to facilitate the conduct of research to improve medical care. Case reports represent an important avenue for trainees (interns, residents, and fellows) and early-stage faculty to demonstrate productive, scholarly activity.