Journal of investigative medicine high impact case reports最新文献_第4页

A Late Recurrent Metastatic Breast Cancer Mimicking Primary Pancreatic Cancer: Case Report. 模仿原发性胰腺癌的晚期复发转移性乳腺癌：病例报告。

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241261511

Saida Sakhri, Ines Zemni, Safa Jouini, Fethia Abidi, Nadia Boujelbene, Tarek Ben Dhiab

{"title":"A Late Recurrent Metastatic Breast Cancer Mimicking Primary Pancreatic Cancer: Case Report.","authors":"Saida Sakhri, Ines Zemni, Safa Jouini, Fethia Abidi, Nadia Boujelbene, Tarek Ben Dhiab","doi":"10.1177/23247096241261511","DOIUrl":"10.1177/23247096241261511","url":null,"abstract":"Metastasis to the pancreas from malignant tumors is a rare event, representing only 1% to 2% of all pancreatic neoplasms. They occur in 2 different clinicopathological settings: as a manifestation in widespread metastatic disease or as an isolated mass in the pancreas. We report the case of a 41-year-old woman who had a history of invasive lobular breast cancer treated with radical surgery, chemotherapy, and radiotherapy. After 21 years of total remission, she presented for severe lower back pain with jaundice, nausea, and loss of 9 kg in 3 months. Abdominal computed tomography demonstrated a hyper vascularized, irregular solid lesion of 2.6 cm × 2.1 cm in the head of the pancreas with discreet biliary duct dilatation and coelio-mesenteric enlarged lymph nodes measuring 2 cm. The diagnosis of pancreatic metastasis from a lobular breast carcinoma was made by percutaneous biopsy of pancreatic lesion. The multidisciplinary committee decided a palliative treatment. The patient received chemotherapy. The take home message from his case is that we should keep in mind the hypothesis of a solitary metastasis to the pancreas, when the pancreatic lesion develops in a patient who had a clinical history of previous neoplasm especially in those which is known to potentially metastasize to pancreas.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"12 ","pages":"23247096241261511"},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11185037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141331092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Colorectal Carcinoma-An Anomalous Trigger of Adult Hemophagocytic Lymphohistiocytosis. 结直肠癌--成人嗜血细胞淋巴组织细胞增多症的异常诱因。

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241273131

Ameish Govindarajan, Frederick Venter, Akriti Chaudhry, Harsimranjit Kaur, Everardo Cobos, Greti Petersen

引用次数: 0

A Unique Presentation of Bacterial Group G Streptococcus Myopericarditis. 细菌性 G 群链球菌心肌炎的独特表现。

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241286363

Sacide S Ozgur, Nida Ansari, Alan Alcantara, Angela Pais Vidreiro, Ryan Rahman, Yezin Shamoon, Sherif Elkattawy, Rachel Abboud, Rajkumar Doshi, Fayez Shamoon

引用次数: 0

Peritoneal Dialysis-Associated Peritonitis Caused by Achromobacter xylosoxidans: A Case Report and Literature Review. 由木糖酸 Achromobacter xylosoxidans 引起的腹膜透析相关性腹膜炎：病例报告与文献综述

IF 1.2

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096231220467

Ibrahim Tawhari, Samantha Saggese, Shatha S Alshahrani, Ghufran Asiri, Shatha A Alshahrani, Sarah Summan, Yousef Y Al Qasim, Yahya A Al Majbar

{"title":"Peritoneal Dialysis-Associated Peritonitis Caused by Achromobacter xylosoxidans: A Case Report and Literature Review.","authors":"Ibrahim Tawhari, Samantha Saggese, Shatha S Alshahrani, Ghufran Asiri, Shatha A Alshahrani, Sarah Summan, Yousef Y Al Qasim, Yahya A Al Majbar","doi":"10.1177/23247096231220467","DOIUrl":"10.1177/23247096231220467","url":null,"abstract":"Achromobacter xylosoxidans is a gram-negative bacterium that is responsible for rare peritonitis associated with peritoneal dialysis (PD). We present a case of a 64-year-old woman with a medical history of end-stage renal disease undergoing PD who was admitted to the emergency department with abdominal pain and nausea. Physical examination and laboratory studies revealed peritoneal signs and laboratory abnormalities consistent with peritonitis. Intraperitoneal catheter dysfunction was identified and subsequently resolved via laparoscopy. Following a peritoneal fluid culture, A xylosoxidans was identified, leading to the initiation of intraperitoneal meropenem treatment. After an initial improvement, the patient developed an ileus and recurrent abdominal symptoms, and further peritoneal cultures remained positive for A xylosoxidans. Subsequent treatment included intravenous meropenem and vancomycin for Clostridium difficile colitis. Owing to the high likelihood of biofilm formation on the PD catheter by A xylosoxidans, the catheter was removed, and the patient transitioned to hemodialysis. Intravenous meropenem was continued for 2 weeks post-catheter removal. This case highlights the challenges in managing recurrent peritonitis in PD patients caused by multidrug-resistant A xylosoxidans. A high index of suspicion, appropriate microbiological identification, and targeted intraperitoneal and systemic antibiotic treatment, along with catheter management, are crucial in achieving a favorable outcome in such cases.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"12 ","pages":"23247096231220467"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10762871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139074328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Catastrophic Case of West Nile Virus Rhombencephalitis in AIDS. 艾滋病患者西尼罗河病毒性黄斑脑炎的灾难性病例。

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241267132

Rupam Sharma, Elika Salimi, Carlos D'Assumpcao, Michael Valdez, Akriti Chaudhry, Arash Heidari, Rasha Kuran, Janpreet Bhandohal

引用次数: 0

AIDS-Associated BK Virus Nephropathy in Native Kidneys: A Case Report and Review of the Literature. 原生肾中的艾滋病相关 BK 病毒肾病：病例报告和文献综述。

IF 1.2

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241232202

Niloufar Ebrahimi, Maha Al Baghdadi, Craig W Zuppan, Daniel K Rogstad, Amir Abdipour

{"title":"AIDS-Associated BK Virus Nephropathy in Native Kidneys: A Case Report and Review of the Literature.","authors":"Niloufar Ebrahimi, Maha Al Baghdadi, Craig W Zuppan, Daniel K Rogstad, Amir Abdipour","doi":"10.1177/23247096241232202","DOIUrl":"10.1177/23247096241232202","url":null,"abstract":"BK virus (BKV) is a small DNA virus, a member of the polyomavirus family, that causes an opportunistic infection in immunocompromised patients, especially kidney transplant patients. This virus establishes a lifelong infection in most of the population, and once it reactivates in an immunocompromised state, leads to BKV nephropathy. This review seeks to assess the correlation between severe immunosuppression, evident by low CD4 cell counts in HIV-positive patients, and the reactivation of BKV, causing nephropathy. A literature review was conducted, extracting, and analyzing case reports of HIV-positive patients showing correlations between their degree of immunosuppression, as evidenced by their CD4 counts, and the degree of BKV infectivity, confirmed by kidney biopsy. A total of 12 cases of BKV nephropathy in HIV-infected patients were reviewed. A common finding was the presence of profound immunosuppression, with most patients having CD4 counts ≤50 cells/ mm3. A substantial number also had comorbid malignancies, with some undergoing chemotherapy, potentially increasing the risk of BKV reactivation. In addition to the HIV status and malignancies, other risk factors for BKV reactivation included older age, male gender, diabetes mellitus, Caucasian race, and ureteral stent placement. BKV nephropathy in HIV patients with native kidneys is closely correlated with severe immunosuppression. Although therapeutic strategies exist for post-transplant patients, aside from the treatment of HIV with highly active anti-retroviral therapy (HAART), which potentially helps with clearing BKV by increasing CD4 count, there is no definitive treatment for a native kidney BKV nephropathy in patients with AIDS. The complexity of the cases and severity of comorbidities indicate the need for further research to develop therapeutic strategies tailored to this population.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"12 ","pages":"23247096241232202"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10880537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139905811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beware of the Acute Respiratory Distress Syndrome in a Pulmonary Blastomycosis! 谨防肺疫急性呼吸窘迫综合征！

IF 1.2

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241233042

Avinash Vangara, Dedeepya Gullapalli, Jayaram Krishna Depa, Sandhya Kolagatla, Muhammad Ali, Subramanya Shyam Ganti

{"title":"Beware of the Acute Respiratory Distress Syndrome in a Pulmonary Blastomycosis!","authors":"Avinash Vangara, Dedeepya Gullapalli, Jayaram Krishna Depa, Sandhya Kolagatla, Muhammad Ali, Subramanya Shyam Ganti","doi":"10.1177/23247096241233042","DOIUrl":"10.1177/23247096241233042","url":null,"abstract":"Blastomyces dermatitidis is a dimorphic fungus that can range from mild to severe disease presentation, including the acute respiratory distress syndrome (ARDS) based on the individual's immunity. Acute respiratory distress syndrome is an uncommon presentation having an incidence of about 10% to 15% but has a high mortality exceeding 90%. This is a case of a 50-year-old female with past medical history of asthma and type 2 diabetes mellitus who presented to the pulmonology clinic with worsening dyspnea for the last 2 months. She also had a lesion in the left lower back, which was draining purulent fluid. Chest radiographs showed bilateral infiltrates and was started empirically on vancomycin and piperacillin-tazobactam. Bronchoalveolar lavage was done and the cultures grew B dermatitidis. The patient was moved to a higher level of care and given amphotericin B. Unfortunately, the patient experienced septic shock, which later deteriorated into cardiac arrest, ultimately leading to their passing. The importance of early diagnosis of blastomycosis and timely treatment has been emphasized in this case report.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"12 ","pages":"23247096241233042"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10880536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139905812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facial Hyperpigmentation: A Rare Side Effect of Adalimumab. 面部色素沉着：阿达木单抗的罕见副作用

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241265896

Malek Mrad, Mariam Tabka, Asmahane Souissi, Ines Chelly, Mourad Mokni

引用次数: 0

A Rare Case of Solitary Endobronchial Plasmacytoma Presented With Complete Airway Obstruction: A Case Report.

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241299282

Mohamad Banat, Anas Abukhalaf, Lilian Faqiat, Razan Takroori, Yousef Abu Asbeh

{"title":"A Rare Case of Solitary Endobronchial Plasmacytoma Presented With Complete Airway Obstruction: A Case Report.","authors":"Mohamad Banat, Anas Abukhalaf, Lilian Faqiat, Razan Takroori, Yousef Abu Asbeh","doi":"10.1177/23247096241299282","DOIUrl":"10.1177/23247096241299282","url":null,"abstract":"This case report presents a rare instance of solitary endobronchial plasmacytoma in a 58-year-old male, who had progressively worsening shortness of breath and a productive cough. The patient, who had a smoking history, was found to have a large, hypervascular mass completely obstructing the right main bronchus, confirmed as a plasma cell tumor via endoscopic biopsy. Further diagnostic imaging, including positron emission tomography-computed tomography (PET-CT) and chest CT, revealed a mass measuring 1.7 cm with abnormal fluorodeoxyglucose (FDG) uptake. The bone marrow biopsy ruled out multiple myeloma. The patient underwent challenging endoscopic debulking of the tumor, although margins were not well defined due to its size. Post-operatively, the patient showed significant symptomatic improvement and was discharged home on post-operative day 4. Two months after the procedure, follow-up with a chest CT scan and bronchoscopy showed no evidence of residual tumor or local recurrence, and the patient reported significant respiratory improvement. The literature review revealed that extramedullary plasmacytoma (EMP) is uncommon and often occurs in the upper aerodigestive tract. The diagnostic workup generally involves histopathological analysis, bronchoscopy, and imaging studies. Treatment is tailored to the patient's condition and the characteristics of the tumor. This case underscores the need for a high index of suspicion and comprehensive diagnostic evaluation of patients presenting with obstructive bronchial mass. Furthermore, it highlights the importance of considering endobronchial plasmacytoma in the differential diagnosis of obstructive bronchial masses and the value of early intervention in achieving favorable outcomes. Regular follow-up is crucial to monitor recurrence and ensure ongoing patient well-being.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"12 ","pages":"23247096241299282"},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11618910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case Report of Pulmonary Vein Stenosis Within the Labyrinth of Fibrosing Mediastinitis. 纤维性纵隔炎迷宫内肺静脉狭窄病例报告

IF 1.2

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241244729

Zakaria Alagha, Catherine Adams, Kylie Johnson, Amro Al-Astal

{"title":"A Case Report of Pulmonary Vein Stenosis Within the Labyrinth of Fibrosing Mediastinitis.","authors":"Zakaria Alagha, Catherine Adams, Kylie Johnson, Amro Al-Astal","doi":"10.1177/23247096241244729","DOIUrl":"10.1177/23247096241244729","url":null,"abstract":"This case centers on a 76-year-old male experiencing exertional dyspnea and hemoptysis, with a medical history marked by recurrent pulmonary embolism and chronic obstructive pulmonary disease (COPD). Notably, he resides in a histoplasmosis-endemic area. A computed tomography (CT) pulmonary embolism scan revealed notable findings, including an enlarged right lower pulmonary artery, vascular congestion, atelectasis, and a mass exerting pressure on the right lower pulmonary vein. Biopsy results identified the mass as fibrosing mediastinitis, likely attributed to histoplasmosis. A transthoracic echocardiogram indicated right ventricular dilatation, impaired function, and a right ventricular systolic pressure of 63 mm Hg. During right heart catheterization, the patient displayed disparate pulmonary artery wedge pressures (PAWPs) between the right and left sides. This discrepancy was linked to a blunted back wave from the left atrium to the catheter, induced by pulmonary vein compression. Although an infrequent phenomenon, the recorded asymmetry in PAWPs played a crucial role in guiding accurate patient management. The absence of subsequent evaluation of PAWP on the left side could have altered the treatment plan, potentially delaying appropriate patient care. This case emphasizes the necessity of thorough exploration with right heart catheterization when clinical symptoms warrant, highlighting the importance of standardized practices in such procedures.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"12 ","pages":"23247096241244729"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10996351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140870450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0