超越全身虚弱：他汀类药物引起的免疫介导的坏死性肌病的罕见病例。

IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL

Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-05-26 DOI:10.1177/23247096251344727

Leo Sakai, Hana Kazbour, James Huang

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引用次数: 0

摘要

他汀类药物诱导的免疫介导坏死性肌病（IMNM）是一种罕见的特发性炎症性肌病，与他汀类药物暴露有关，其特征是抗羟甲基戊二酰辅酶a还原酶抗体阳性。在这里，我们描述了一个66岁的男性病例，他在长期使用他汀类药物的情况下被诊断为横纹肌溶解，但后来在他汀类药物引起的IMNM症状难以治疗后被证实。当停用他汀类药物后，他汀类药物相关肌肉症状未能缓解时，该病例强调了临床高度怀疑他汀类药物引起的IMNM的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Beyond the Generalized Weakness: A Rare Case of Statin-Induced Immune-Mediated Necrotizing Myopathy.

Statin-induced immune-mediated necrotizing myopathy (IMNM) is a rare subtype of idiopathic inflammatory myopathy associated with statin exposure and characterized by positive anti-hydroxymethylglutaryl coenzyme A reductase antibodies. Here, we describe a case of a 66-year-old male who was admitted with the presumed diagnosis of rhabdomyolysis in the setting of chronic statin use but was later confirmed to have statin-induced IMNM after his symptoms were refractory to treatment. This case highlights the importance of having a high clinical suspicion for statin-induced IMNM when statin-associated muscle symptoms fail to resolve after the discontinuation of statins.

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来源期刊

Journal of investigative medicine high impact case reports MEDICINE, GENERAL & INTERNAL-

CiteScore

1.90

自引率

0.00%

发文量

165

审稿时长

12 weeks

期刊介绍： The AFMR is committed to enhancing the training and career development of our members and to furthering its mission to facilitate the conduct of research to improve medical care. Case reports represent an important avenue for trainees (interns, residents, and fellows) and early-stage faculty to demonstrate productive, scholarly activity.