Perfectionnement en Pédiatrie最新文献

{"title":"Title Page","authors":"","doi":"10.1016/S2588-932X(24)00079-2","DOIUrl":"https://doi.org/10.1016/S2588-932X(24)00079-2","url":null,"abstract":"","PeriodicalId":101006,"journal":{"name":"Perfectionnement en Pédiatrie","volume":"7 2","pages":"Page i"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141083510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ingestion de corps étranger chez l'enfant","authors":"S. Morin, L. Bridoux-Henno","doi":"10.1016/S2588-932X(24)00086-X","DOIUrl":"https://doi.org/10.1016/S2588-932X(24)00086-X","url":null,"abstract":"","PeriodicalId":101006,"journal":{"name":"Perfectionnement en Pédiatrie","volume":"7 2","pages":"Pages 2S8-2S10"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141084597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acidose métabolique chez l'enfant","authors":"J. Bouchereau , A. De Mul","doi":"10.1016/S2588-932X(24)00084-6","DOIUrl":"https://doi.org/10.1016/S2588-932X(24)00084-6","url":null,"abstract":"","PeriodicalId":101006,"journal":{"name":"Perfectionnement en Pédiatrie","volume":"7 2","pages":"Pages 2S2-2S4"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141084595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urticaire chronique de l'enfant","authors":"A. Lasek Duriez , L. Martin , P. Cros","doi":"10.1016/S2588-932X(24)00090-1","DOIUrl":"https://doi.org/10.1016/S2588-932X(24)00090-1","url":null,"abstract":"","PeriodicalId":101006,"journal":{"name":"Perfectionnement en Pédiatrie","volume":"7 2","pages":"Pages 2S21-2S23"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141083463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Préface","authors":"Thierry LAMIREAU","doi":"10.1016/S2588-932X(24)00083-4","DOIUrl":"https://doi.org/10.1016/S2588-932X(24)00083-4","url":null,"abstract":"","PeriodicalId":101006,"journal":{"name":"Perfectionnement en Pédiatrie","volume":"7 2","pages":"Page 2S1"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141083476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malaise du nourrisson","authors":"G. Mortamet , E. Launay","doi":"10.1016/S2588-932X(24)00088-3","DOIUrl":"https://doi.org/10.1016/S2588-932X(24)00088-3","url":null,"abstract":"","PeriodicalId":101006,"journal":{"name":"Perfectionnement en Pédiatrie","volume":"7 2","pages":"Pages 2S14-2S16"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141083461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compléments de préparations pour nourrisson à base de lait de vache chez les nourrissons allaités au sein et prévention primaire de l’allergie aux protéines du lait de vache : avis du Comité de nutrition de la Société française de pédiatrie","authors":"Alain Bocquet , Christophe Dupont , Sandra Brancato , André Briend , Martin Chalumeau , Dominique Darmaun , Arnaud de Luca , François Feillet , Marie-Laure Frelut , Dominique Guimber , Alexandre Lapillonne , Agnès Linglart , Noel Peretti , Jean-Christophe Roze , Umberto Simeoni , Dominique Turck , Jean-Pierre Chouraqui , Comité de Nutrition de la Société française de pédiatrie","doi":"10.1016/j.perped.2024.01.004","DOIUrl":"10.1016/j.perped.2024.01.004","url":null,"abstract":"","PeriodicalId":101006,"journal":{"name":"Perfectionnement en Pédiatrie","volume":"7 1","pages":"Pages 14-18"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139816875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergie à l’arachide chez l’enfant","authors":"Stéphanie Wanin ,&nbsp;Mélisande Bourgoin-Heck","doi":"10.1016/j.perped.2024.01.014","DOIUrl":"10.1016/j.perped.2024.01.014","url":null,"abstract":"<div><p>L’allergie à l’arachide est la première cause d’anaphylaxie chez l’enfant. Un diagnostic précis est nécessaire, incluant les IgE spécifiques des composants allergéniques ; les allergies croisées éventuelles doivent être recherchées. La prise en charge inclue avant tout le régime d’éviction, idéalement avec l’aide d’un(e) diététicien(ne), la prescription d’une trousse d’urgence avec dispositif auto-injectable d’adrénaline, et la mise en place d’un PAI. L’éducation thérapeutique est le complément indispensable à ces différentes mesures. L’immunothérapie orale est prometteuse, réservée à ce stade aux centres experts. Elle doit faire l’objet d’une décision médicale partagée avec la famille, en tenant compte des bénéfices attendus (acquisition d’une tolérance, rarement guérison), des effets indésirables éventuels, et de l’impact sur la qualité de vie.</p></div><div><p>Peanut allergy is the leading cause of anaphylaxis in children. An accurate diagnosis is necessary, including specific IgE testing for allergenic components, and potential cross-allergies should also be investigated. Primary management involves an elimination diet, ideally with the assistance of a dietician, the prescription of an emergency kit with self-injectable adrenaline device, and the implementation of an individualized healthcare plan (PAI) for the child. Therapeutic education is the essential complement to these measures. Oral immunotherapy is promising but is currently reserved for expert centers. The decision to pursue immunotherapy should involve shared decision-making with the family, carefully considering the expected benefits (such as tolerance acquisition, albeit rarely leading to a cure), potential adverse effects, and its impact on the quality of life.</p></div>","PeriodicalId":101006,"journal":{"name":"Perfectionnement en Pédiatrie","volume":"7 1","pages":"Pages 23-31"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139824301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Que faire en cas de découverte de lyse isthmique L5 ?","authors":"Yan Lefèvre","doi":"10.1016/j.perped.2024.01.012","DOIUrl":"10.1016/j.perped.2024.01.012","url":null,"abstract":"","PeriodicalId":101006,"journal":{"name":"Perfectionnement en Pédiatrie","volume":"7 1","pages":"Pages 19-22"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139873879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thrombopénies constitutionnelles","authors":"Cécile Lavenu-Bombled ,&nbsp;Céline Falaise ,&nbsp;Adeline Blandinieres ,&nbsp;Paquita Nurden ,&nbsp;Marie-Christine Alessi ,&nbsp;Paul Saultier","doi":"10.1016/j.perped.2024.01.011","DOIUrl":"10.1016/j.perped.2024.01.011","url":null,"abstract":"<div><p>Les thrombopénies constitutionnelles sont des affections rares d’origine génétique, caractérisées par une diminution du nombre des plaquettes sanguines. Ces pathologies sont fréquemment diagnostiquées chez les enfants et peuvent être associées à des saignements et à des atteintes syndromiques. L’identification de nouvelles causes génétiques a été facilitée par les techniques de séquençage à haut débit. Au cours de la dernière décennie, les thrombopénies constitutionnelles ont vu le nombre de gènes impliqués augmenter significativement. Ces anomalies touchent principalement les récepteurs membranaires, les organites intra-plaquettaires, les protéines de signalisation, les éléments du cytosquelette et les facteurs de transcription de la mégacaryopoïèse. Les thrombopénies constitutionnelles, hétérogènes en présentation et gravité, nécessitent un diagnostic étiologique précis pour évaluer le risque hémorragique et mettre en place d’éventuelles mesures prophylactiques. Plus de la moitié des patients sont sujets à des complications hématologiques ou extra-hématologiques sévères. Les techniques de séquençage nouvelle génération sont désormais facilement accessibles pour le diagnostic des thrombopénies constitutionnelles, même si l’étiologie reste inconnue dans 30 à 40 % des cas. Sur le plan thérapeutique, la transfusion de plaquettes reste le traitement de référence des manifestations hémorragiques sévères. De nouvelles classes de médicaments, comme les agonistes du récepteur de la thrombopoïétine, pourraient jouer un rôle clé à l’avenir. Le développement de la thérapie génique pour les formes sévères et de nouveaux traitements visant à réduire les transfusions plaquettaires sont des objectifs de recherche prioritaires.</p></div><div><p>Constitutional thrombocytopenias comprise a subset of rare genetic disorders characterized by a diminished count of blood platelets. These conditions typically manifest during childhood and frequently present with concomitant bleeding tendencies and syndromic features. The advent of high-throughput sequencing methodologies has significantly expedited the discovery of novel genetic underpinnings associated with these conditions. Notably, over the past decade, constitutional thrombocytopenias have witnessed a substantial expansion in the number of implicated genes. These genetic anomalies primarily impinge upon membrane receptors, intraplatelet organelles, signaling proteins, cytoskeletal elements, and transcriptional factors pivotal in the process of megakaryopoiesis. Constitutional thrombocytopenias, characterized by a heterogeneous spectrum of clinical presentation and disease severity, necessitate precise etiological delineation for an accurate assessment of hemorrhagic risk and the formulation of potential prophylactic strategies. It is noteworthy that more than 50% of afflicted individuals are predisposed to experiencing severe hematologic or extra-hematologic complications. The advent of next-generation sequ","PeriodicalId":101006,"journal":{"name":"Perfectionnement en Pédiatrie","volume":"7 1","pages":"Pages 48-60"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2588932X24000111/pdfft?md5=36bb735409d86c53f47c9b62b4cd8327&pid=1-s2.0-S2588932X24000111-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139882245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}