Cognitive NeurodynamicsPub Date : 2025-12-01Epub Date: 2025-06-17DOI: 10.1007/s11571-025-10278-2
Yutao Miao, Kaijie Li, Wenhao Zhao, Yushi Zhang
{"title":"EA-EEG: a novel model for efficient motor imagery EEG classification with whitening and multi-scale feature integration.","authors":"Yutao Miao, Kaijie Li, Wenhao Zhao, Yushi Zhang","doi":"10.1007/s11571-025-10278-2","DOIUrl":"10.1007/s11571-025-10278-2","url":null,"abstract":"<p><p>Electroencephalography (EEG) is a non-invasive technique widely used in neuroscience and brain-computer interfaces (BCI) due to its high temporal resolution. In motor imagery EEG (MI-EEG) tasks, EEG signals reflect movement-related brain activity, making them ideal for BCI control. However, the non-stationary nature of MI-EEG signals poses significant challenges for classification, as frequency characteristics vary across tasks and individuals. Traditional preprocessing methods, such as bandpass filtering and standardization, may struggle to adapt to these variations, potentially limiting classification performance. To address this issue, this study introduces EA-EEG, an improved MI-EEG classification model that incorporates whitening as a preprocessing step to reduce channel correlation and enhance the model feature extraction ability. EA-EEG further leverages a multi-scale pooling strategy, combining convolutional networks and root mean square pooling to extract key spatial and temporal features, and applies prototype-based classification to improve MI-EEG classification performance. Experiments on the BCI4-2A and BCI4-2B datasets demonstrate that EA-EEG achieves state-of-the-art performance, with 85.33% accuracy (Kappa = 0.804) on BCI4-2A and 88.05% accuracy (Kappa = 0.761) on BCI4-2B, surpassing existing approaches. These results confirm EA-EEG's effectiveness in handling non-stationary MI-EEG signals, demonstrating its potential for robust BCI applications, including rehabilitation, prosthetic control, and cognitive monitoring.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"19 1","pages":"94"},"PeriodicalIF":3.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"MBRSTCformer: a knowledge embedded local-global spatiotemporal transformer for emotion recognition.","authors":"Chenglin Lin, Huimin Lu, Chenyu Pan, Songzhe Ma, Zexing Zhang, Runhui Tian","doi":"10.1007/s11571-025-10277-3","DOIUrl":"10.1007/s11571-025-10277-3","url":null,"abstract":"<p><p>Emotion recognition is an essential prerequisite for realizing generalized BCI, which possesses an extensive range of applications in real life. EEG-based emotion recognition has become mainstream due to its real-time mapping of brain emotional activities, so a robust EEG-based emotion recognition model is of great interest. However, most existing deep learning emotion recognition methods treat the EEG signal as a whole feature extraction, which will destroy its local stimulation differences and fail to extract local features of the brain region well. Inspired by the cognitive mechanisms of the brain, we propose the multi-brain regions spatiotemporal collaboration transformer (MBRSTCfromer) framework for EEG-based emotion recognition. First, inspired by the prior knowledge, we propose the Multi-Brain Regions Collaboration Network. The EEG data are processed separately after being divided by brain regions, and stimulation scores are presented to quantify the stimulation produced by different brain regions and feedback on the stimulation degree to the MBRSTCfromer. Second, we propose a Cascade Pyramid Spatial Fusion Temporal Convolution Network for multi-brain regions EEG features fusion. Finally, we conduct comprehensive experiments on two mainstream emotion recognition datasets to validate the effectiveness of our proposed MBRSTCfromer framework. We achieved 98.63 <math><mo>%</mo></math> , 98.15 <math><mo>%</mo></math> , and 98.58 <math><mo>%</mo></math> accuracy on the three dimensions (arousal, valence, and dominance) on the DEAP dataset; and 97.66 <math><mo>%</mo></math> , 97.07 <math><mo>%</mo></math> , and 97.97 <math><mo>%</mo></math> on the DREAMER dataset.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"19 1","pages":"95"},"PeriodicalIF":3.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Naglaa A Abdallah, Hany Elsharawy, Hamiss A Abulela, Roger Thilmony, Abdelhadi A Abdelhadi, Nagwa I Elarabi
{"title":"Multiplex CRISPR/Cas9-mediated genome editing to address drought tolerance in wheat.","authors":"Naglaa A Abdallah, Hany Elsharawy, Hamiss A Abulela, Roger Thilmony, Abdelhadi A Abdelhadi, Nagwa I Elarabi","doi":"10.1080/21645698.2022.2120313","DOIUrl":"10.1080/21645698.2022.2120313","url":null,"abstract":"<p><p>Genome editing tools have rapidly been adopted by plant scientists for crop improvement. Genome editing using a multiplex sgRNA-CRISPR/Cas9 genome editing system is a useful technique for crop improvement in monocot species. In this study, we utilized precise gene editing techniques to generate wheat 3'(2'), 5'-bisphosphate nucleotidase (<i>TaSal1</i>) mutants using a multiplex sgRNA-CRISPR/Cas9 genome editing system. Five active <i>TaSal1</i> homologous genes were found in the genome of Giza168 in addition to another apparently inactive gene on chromosome 4A. Three gRNAs were designed and used to target exons 4, 5 and 7 of the five wheat <i>TaSal1</i> genes. Among the 120 Giza168 transgenic plants, 41 lines exhibited mutations and produced heritable <i>TaSal1</i> mutations in the M<sub>1</sub> progeny and 5 lines were full 5 gene knock-outs. These mutant plants exhibit a rolled-leaf phenotype in young leaves and bended stems, but there were no significant changes in the internode length and width, leaf morphology, and stem shape. Anatomical and scanning electron microscope studies of the young leaves of mutated <i>TaSal1</i> lines showed closed stomata, increased stomata width and increase in the size of the bulliform cells. <i>Sal1</i> mutant seedlings germinated and grew better on media containing polyethylene glycol than wildtype seedlings. Our results indicate that the application of the multiplex sgRNA-CRISPR/Cas9 genome editing is efficient tool for mutating more multiple TaSal1 loci in hexaploid wheat.</p>","PeriodicalId":54282,"journal":{"name":"Gm Crops & Food-Biotechnology in Agriculture and the Food Chain","volume":" ","pages":"1-17"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33490173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neuroenhancement by repetitive transcranial magnetic stimulation (rTMS) on DLPFC in healthy adults.","authors":"Elias Ebrahimzadeh, Seyyed Mostafa Sadjadi, Mostafa Asgarinejad, Amin Dehghani, Lila Rajabion, Hamid Soltanian-Zadeh","doi":"10.1007/s11571-024-10195-w","DOIUrl":"10.1007/s11571-024-10195-w","url":null,"abstract":"<p><p>The term \"neuroenhancement\" describes the enhancement of cognitive function associated with deficiencies resulting from a specific condition. Nevertheless, there is currently no agreed-upon definition for the term \"neuroenhancement\", and its meaning can change based on the specific research being discussed. As humans, our continual pursuit of expanding our capabilities, encompassing both cognitive and motor skills, has led us to explore various tools. Among these, repetitive Transcranial Magnetic Stimulation (rTMS) stands out, yet its potential remains underestimated. Historically, rTMS was predominantly employed in studies focused on rehabilitation objectives. A small amount of research has examined its use on healthy subjects with the goal of improving cognitive abilities like risk-seeking, working memory, attention, cognitive control, learning, computing speed, and decision-making. It appears that the insights gained in this domain largely stem from indirect outcomes of rehabilitation research. This review aims to scrutinize these studies, assessing the effectiveness of rTMS in enhancing cognitive skills in healthy subjects. Given that the dorsolateral prefrontal cortex (DLPFC) has become a popular focus for rTMS in treating psychiatric disorders, corresponding anatomically to Brodmann areas 9 and 46, and considering the documented success of rTMS stimulation on the DLPFC for cognitive improvement, our focus in this review article centers on the DLPFC as the focal point and region of interest. Additionally, recognizing the significance of theta burst magnetic stimulation protocols (TBS) in mimicking the natural firing patterns of the brain to modulate excitability in specific cortical areas with precision, we have incorporated Theta Burst Stimulation (TBS) wave patterns. This inclusion, mirroring brain patterns, is intended to enhance the efficacy of the rTMS method. To ascertain if brain magnetic stimulation consistently improves cognition, a thorough meta-analysis of the existing literature has been conducted. The findings indicate that, after excluding outlier studies, rTMS may improve cognition when compared to appropriate control circumstances. However, there is also a considerable degree of variation among the researches. The navigation strategy used to reach the stimulation site and the stimulation location are important factors that contribute to the variation between studies. The results of this study can provide professional athletes, firefighters, bodyguards, and therapists-among others in high-risk professions-with insightful information that can help them perform better on the job.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"19 1","pages":"34"},"PeriodicalIF":3.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cognitive NeurodynamicsPub Date : 2025-12-01Epub Date: 2025-04-04DOI: 10.1007/s11571-025-10244-y
Kai Yang, Xiaojuan Sun, Zengbin Wang
{"title":"The dynamic impact of adult neurogenesis on pattern separation within the dentate gyrus neural network.","authors":"Kai Yang, Xiaojuan Sun, Zengbin Wang","doi":"10.1007/s11571-025-10244-y","DOIUrl":"10.1007/s11571-025-10244-y","url":null,"abstract":"<p><p>Pattern separation in the dentate gyrus (DG) is crucial for distinguishing similar memories. The DG continues to undergo neurogenesis throughout the lifespan, and adult hippocampus neurogenesis leads to the incorporation of thousands of adult-born granule cells (adult-born GCs) into the existing DG circuitry. These newborn GCs exhibit high excitability and are easier to respond to novel stimuli, which seems to be contrary to the requirement of pattern separation for high input specificity. Meanwhile, the changes brought about by the growth of adult-born GCs can not be ignored. Here, we build a biologically relevant model of the DG containing adult-born GCs and test it using the Modified National Institute of Standards and Technology (MNIST) database. By analyzing this model, the results show that the net effect of adult-born GCs to GCs is inhibition, thereby improving the sparsity of GCs and pattern separation. This provides computational evidence for \"indirect encoding\" of adult-born GCs. In addition, as adult-born GCs transition toward maturity, they have the following growth characteristics: decreased activity, increased coupling strength with feedback inhibition, and enhanced synaptic plasticity. We find that the decreased activity reduces pattern separation efficiency while the other characteristics increase pattern separation efficiency. Finally, given that the firing rate of entorhinal cortex (EC) neurons is influenced by numerous factors (such as the complexity of memory tasks), the input frequency to the DG should be within a range rather than being fixed. To address this, we gradually increase the input frequency and notice that the presence of adult-born GCs increases the adaptability of the DG neural network and thus improves the robustness of pattern separation.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"19 1","pages":"57"},"PeriodicalIF":3.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cognitive NeurodynamicsPub Date : 2025-12-01Epub Date: 2025-01-15DOI: 10.1007/s11571-025-10217-1
Muhammad Umair Safdar, Tariq Shah, Asif Ali
{"title":"An effective encryption approach using a combination of a non-chain ring and a four-dimensional chaotic map.","authors":"Muhammad Umair Safdar, Tariq Shah, Asif Ali","doi":"10.1007/s11571-025-10217-1","DOIUrl":"10.1007/s11571-025-10217-1","url":null,"abstract":"<p><p>Algebraic structures are highly effective in designing symmetric key cryptosystems; however, if the key space is not sufficiently large, such systems become vulnerable to brute-force attacks. To address this challenge, our research focuses on enlarging the key space in symmetric key schemes by integrating the non-chain ring with a four-dimensional chaotic system. While chaotic maps offer significant potential for data processing, relying solely on them does not fully leverage their operational advantages. Therefore, it is essential to incorporate algebraic structures that enhance the complexity of the scheme. In the proposed technique, four-dimensional chaotic sequences are employed for image pixel permutation, diffusion, and exclusive-or operations. The scheme is further strengthened against chosen and known plaintext attacks by incorporating pixel values during the exclusive-or operation, where images are XORed with hashed images and keys generated from chaotic sequences. The effectiveness of the technique, its resilience to various forms of attack, and its feasibility for practical implementation are demonstrated through extensive testing and a comprehensive security analysis.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"19 1","pages":"27"},"PeriodicalIF":3.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multi-view domain adaption based multi-scale convolutional conditional invertible discriminator for cross-subject electroencephalogram emotion recognition.","authors":"Sivasaravana Babu S, Prabhu Venkatesan, Parthasarathy Velusamy, Saravana Kumar Ganesan","doi":"10.1007/s11571-024-10193-y","DOIUrl":"10.1007/s11571-024-10193-y","url":null,"abstract":"<p><p>Cross subject Electroencephalogram (EEG) emotion recognition refers to the process of utilizing electroencephalogram signals to recognize and classify emotions across different individuals. It tracks neural electrical patterns, and by analyzing these signals, it's possible to infer a person's emotional state. The objective of cross-subject recognition is to create models or algorithms that can reliably detect emotions in both the same person and several other people. Accurately predicting emotions poses challenges due to dynamic traits. Models struggle with feature extraction, convergence, and negative transfer issues, hindering cross subject emotion recognition. The proposed model employs thorough signal preprocessing, Short-Time Geodesic Flow Kernel Fourier Transform (STGFKFT) for feature extraction, enhancing classifiers' accuracy. Multi-view sheaf attention improves feature discrimination, while the Multi-Scale Convolutional Conditional Invertible Puma Discriminator Neural Network (MSCCIPDNN) framework ensures generalization. Efficient computational techniques and the puma optimization algorithm enhance model robustness and convergence. The suggested framework demonstrates extraordinary success with high accuracy, of 99.5%, 99% and 99.50% for SEED, SEED-IV, and DEAP dataset sequentially. By incorporating these techniques, the proposed method aims to precisely recognition emotions, and accurately captures the features, thereby overcoming the limitations of existing methodologies.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"19 1","pages":"23"},"PeriodicalIF":3.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cognitive NeurodynamicsPub Date : 2025-12-01Epub Date: 2025-01-13DOI: 10.1007/s11571-024-10202-0
V Kavitha, R Siva
{"title":"3T dilated inception network for enhanced autism spectrum disorder diagnosis using resting-state fMRI data.","authors":"V Kavitha, R Siva","doi":"10.1007/s11571-024-10202-0","DOIUrl":"10.1007/s11571-024-10202-0","url":null,"abstract":"<p><p>Autism spectrum disorder (ASD) is one of the complicated neurodevelopmental disorders that impacts the daily functioning and social interactions of individuals. It includes diverse symptoms and severity levels, making it challenging to diagnose and treat efficiently. Various deep learning (DL) based methods have been developed for diagnosing ASD, which rely heavily on behavioral assessment. However, existing techniques have suffered from poor diagnostic outcomes, higher computational complexity, and overfitting issues. To address these challenges, this research work introduces an innovative framework called 3T Dilated Inception Network (3T-DINet) for effective ASD diagnosis using resting-state functional Magnetic Resonance Imaging (rs-fMRI) images. The proposed 3T-DINet technique designs a 3T dilated inception module that incorporates dilated convolutions along with the inception module, allowing it to extract multi-scale features from brain connectivity patterns. The 3T dilated inception module uses three distinct dilation rates (low, medium, and high) in parallel to determine local, mid-level, and global features from the brain. In addition, the proposed approach implements Residual networks (ResNet) to avoid the vanishing gradient problem and enhance the feature extraction ability. The model is further optimized using a Crossover-based Black Widow Optimization (CBWO) algorithm that fine-tunes the hyperparameters thereby enhancing the overall performance of the model. Further, the performance of the 3T-DINet model is evaluated using the five ASD datasets with distinct evaluation parameters. The proposed 3T-DINet technique achieved superior diagnosis results compared to recent previous works. From this simulation validation, it's clear that the 3T-DINet provides an excellent contribution to early ASD diagnosis and enhances patient treatment outcomes.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"19 1","pages":"22"},"PeriodicalIF":3.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cognitive NeurodynamicsPub Date : 2025-12-01Epub Date: 2025-01-09DOI: 10.1007/s11571-024-10211-z
Zhangzhi Zhou, Mi Lin, Xuanxuan Zhou, Chong Zhang
{"title":"Implementation of memristive emotion associative learning circuit.","authors":"Zhangzhi Zhou, Mi Lin, Xuanxuan Zhou, Chong Zhang","doi":"10.1007/s11571-024-10211-z","DOIUrl":"10.1007/s11571-024-10211-z","url":null,"abstract":"<p><p>Psychological studies have demonstrated that the music can affect memory by triggering different emotions. Building on the relationships among music, emotion, and memory, a memristor-based emotion associative learning circuit is designed by utilizing the nonlinear and non-volatile characteristics of memristors, which includes a music judgment module, three emotion generation modules, three emotional homeostasis modules, and a memory module to implement functions such as learning, second learning, forgetting, emotion generation, and emotional homeostasis. The experimental results indicate that the proposed circuit can simulate the learning and forgetting processes of human under different music circumstances, demonstrate the feasibility of memristors in biomimetic circuits, verify the impact of music on memory, and provide a foundation for in-depth research and application development of the interaction mechanism between emotion and memory.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"19 1","pages":"13"},"PeriodicalIF":3.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cognitive NeurodynamicsPub Date : 2025-12-01Epub Date: 2025-01-09DOI: 10.1007/s11571-024-10198-7
Digambar V Puri, Jayanand P Gawande, Pramod H Kachare, Ibrahim Al-Shourbaji
{"title":"Optimal time-frequency localized wavelet filters for identification of Alzheimer's disease from EEG signals.","authors":"Digambar V Puri, Jayanand P Gawande, Pramod H Kachare, Ibrahim Al-Shourbaji","doi":"10.1007/s11571-024-10198-7","DOIUrl":"10.1007/s11571-024-10198-7","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a chronic disability that occurs due to the loss of neurons. The traditional methods to detect AD involve questionnaires and expensive neuro-imaging tests, which are time-consuming, subjective, and inconvenient to the target population. To overcome these limitations, Electroencephalogram (EEG) based methods have been developed to classify AD patients from normal controlled (NC) and mild cognitive impairment (MCI) subjects. Most of the EEG-based methods involved entropy-based feature extraction and discrete wavelet transform. However, the existing AD classification methods failed to provide promising classification accuracy. Here, we proposed a wavelet-machine learning (ML) framework to detect AD using a newly designed biorthogonal filter bank by optimization of frequency and time localization of triplet halfband filter banks (OTFL-THFB). The OTFL-THFB decomposes EEG signals into various EEG sub- bands. Hjorth Parameters (HP) and Higuchi's Fractal Dimension (HFD) have been investigated to extract features from each EEG subband. Subsequently, ML models are trained and tested using different features such as OTFL-THFB with HFD, OTFL-THFB with HP, and OTFL-THFB with HFD and HP used for detecting AD with 10-fold cross-validation. This method was applied to two publicly available datasets. Our model achieved an accuracy of <math><mrow><mn>98.91</mn> <mo>%</mo></mrow> </math> for AD versus NC and <math><mrow><mn>98.65</mn> <mo>%</mo></mrow> </math> for AD versus MCI versus NC using the least square support vector machine. Results indicate that this framework surpassed existing state-of-the-art techniques for classifying AD from NC.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"19 1","pages":"12"},"PeriodicalIF":3.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}