IF 4.5 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-03-01 DOI: 10.1080/21691401.2025.2471762

Jian Huang, Lu Wang, Jiangfei Zhou, Tianming Dai, Weicong Zhu, Tianrui Wang, Hongde Wang, Yingze Zhang

{"title":"Unveiling the ageing-related genes in diagnosing osteoarthritis with metabolic syndrome by integrated bioinformatics analysis and machine learning.","authors":"Jian Huang, Lu Wang, Jiangfei Zhou, Tianming Dai, Weicong Zhu, Tianrui Wang, Hongde Wang, Yingze Zhang","doi":"10.1080/21691401.2025.2471762","DOIUrl":"https://doi.org/10.1080/21691401.2025.2471762","url":null,"abstract":"Ageing significantly contributes to osteoarthritis (OA) and metabolic syndrome (MetS) pathogenesis, yet the underlying mechanisms remain unknown. This study aimed to identify ageing-related biomarkers in OA patients with MetS. OA and MetS datasets and ageing-related genes (ARGs) were retrieved from public databases. The limma package was used to identify differentially expressed genes (DEGs), and weighted gene coexpression network analysis (WGCNA) screened gene modules, and machine learning algorithms, such as random forest (RF), support vector machine (SVM), generalised linear model (GLM), and extreme gradient boosting (XGB), were employed. The nomogram and receiver operating characteristic (ROC) curve assess the diagnostic value, and CIBERSORT analysed immune cell infiltration. We identified 20 intersecting genes among DEGs of OA, key module genes of MetS, and ARGs. By comparing the accuracy of the four machine learning models for disease prediction, the SVM model, which includes CEBPB, PTEN, ARPC1B, PIK3R1, and CDC42, was selected. These hub ARGs not only demonstrated strong diagnostic values based on nomogram data but also exhibited a significant correlation with immune cell infiltration. Building on these findings, we have identified five hub ARGs that are associated with immune cell infiltration and have constructed a nomogram aimed at early diagnosing OA patients with MetS.","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"53 1","pages":"57-68"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Designs of Upper Limb Tremor Suppression Orthoses: Efficacy and Wearer's Comfort.

IF 0.8 4区医学

Journal of Medical Devices-Transactions of the Asme Pub Date : 2025-06-01 Epub Date: 2024-12-11 DOI: 10.1115/1.4066968

MoYan ChiGan, Manlong Chen, Min Jing

引用次数: 0

Corrigendum to "Electrospun PLGA and PLGA/gelatin scaffolds for tubularized urethral replacement: Studies in vitro and in vivo". 用于管状尿道置换的电纺聚乳酸和聚乳酸/明胶支架：体外和体内研究"。

IF 2.3 4区医学

Journal of Biomaterials Applications Pub Date : 2025-04-01 Epub Date: 2023-12-29 DOI: 10.1177/08853282231217938

引用次数: 0

Impact of composition and surfactant-templating on mesoporous bioactive glasses structural evolution, bioactivity, and drug delivery property. 组成和表面活性剂模板对介孔生物活性玻璃结构演变、生物活性和药物传递特性的影响。

IF 2.3 4区医学

Journal of Biomaterials Applications Pub Date : 2025-04-01 Epub Date: 2025-01-08 DOI: 10.1177/08853282241312040

Dana Almasri, Yaser Dahman

{"title":"Impact of composition and surfactant-templating on mesoporous bioactive glasses structural evolution, bioactivity, and drug delivery property.","authors":"Dana Almasri, Yaser Dahman","doi":"10.1177/08853282241312040","DOIUrl":"10.1177/08853282241312040","url":null,"abstract":"This study explores mesoporous bioactive glasses (MBGs) that show promise as advanced therapeutic delivery platforms owing to their tailorable porous properties enabling enhanced drug loading capacity and biomimetic chemistry for localized, sustained release. This work systematically investigates the complex relationship between MBG composition and surfactant templating on structural evolution, in vitro bioactive response, resultant drug loading efficiency and release. A total of 12 samples of sol-gel-derived MBG were synthesized using cationic and non-ionic structure-directing agents (cetyltrimethylammonium bromide, Pluronic F127 and P123) while modulating the SiO2/CaO content, generating MBG with surface areas of 60-695 m2/g. Electron microscopy and nitrogen desorption studies verified the successful synthesis of the 12 ordered MBG formulations. Assessment of hydroxyapatite conversion kinetics via FTIR spectroscopy and SEM demonstrated accelerated deposition for 70-80% SiO2 formulations, independent of the surfactant used. However, the templating agent had an impact on drug loading as observed in this study where MBG synthesized by the templating agent Pluronic P123 had higher drug loading compared to the other surfactants. To determine the drug release mechanisms, the in vitro kinetic profiles were fitted to various mathematical models including ze-ro. Most compositions exhibited release properties closest to zero-order, indicating a concentration-independent drug elution rate. These results in this study explain the relationship between tailored hierarchical architecture and intrinsic ion release rates to enable advanced functionality.","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"1064-1083"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovative buccal film delivery system for hypertension: Combining candesartan and hydrochlorothiazide.

IF 2.3 4区医学

Journal of Biomaterials Applications Pub Date : 2025-04-01 Epub Date: 2025-02-01 DOI: 10.1177/08853282251317853

Ola Tarawneh, Aisha Kanan, Walid Al-Zyoud, Mohammad Khanfar, Mohammad Hailat, Ala A Alhusban, Razan Abu Jaber

{"title":"Innovative buccal film delivery system for hypertension: Combining candesartan and hydrochlorothiazide.","authors":"Ola Tarawneh, Aisha Kanan, Walid Al-Zyoud, Mohammad Khanfar, Mohammad Hailat, Ala A Alhusban, Razan Abu Jaber","doi":"10.1177/08853282251317853","DOIUrl":"10.1177/08853282251317853","url":null,"abstract":"This study explores the development of buccal films as an innovative drug delivery system for hypertension management, combining candesartan cilexetil (CC) and hydrochlorothiazide (HCTZ). Utilizing a solvent casting technique, films were prepared with various polymers, including PVA, PVP, and CMC Na, and enhanced with plasticizers to improve solubility and bioavailability. The films were evaluated for physicochemical and mechanical properties, disintegration time, and drug content uniformity. Results demonstrated that the films were visually uniform, with excellent folding endurance and a neutral pH. The formulation containing PVA, PVP, and CMC Na exhibited the fastest disintegration rate and superior bioadhesion. The use of Dynamic Mechanical Thermal Analysis (DMTA) confirmed the miscibility of the drugs within the polymeric matrix, ensuring effective delivery. This novel formulation offers significant advantages by improving patient compliance and bypassing first-pass metabolism, presenting a promising alternative for hypertension treatment.","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"1014-1029"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction: Transplantation of copper-doped calcium polyphosphate scaffolds combined with copper (II) preconditioned bone marrow mesenchymal stem cells for bone defect repair. 撤回：移植掺铜聚磷酸钙支架与铜（II）预处理骨髓间充质干细胞用于骨缺损修复。

IF 2.3 4区医学

Journal of Biomaterials Applications Pub Date : 2025-04-01 Epub Date: 2024-10-24 DOI: 10.1177/08853282241284192

引用次数: 0

Comprehensive review of 3D printing techniques emphasizing thermal characterization in biomedical prototyping. 全面回顾 3D 打印技术，强调生物医学原型制作中的热特性分析。

IF 2.3 4区医学

Journal of Biomaterials Applications Pub Date : 2025-04-01 Epub Date: 2025-01-12 DOI: 10.1177/08853282251314672

Jayeeta Chattopadhyay, Nimmy Srivastava, Tara Sankar Pathak

引用次数: 0

Mechanobiological enhancement of electrospun PCL/nHA membranes for guided tissue regeneration applications. 静电纺丝PCL/nHA膜在引导组织再生应用中的机械生物学增强。

IF 2.3 4区医学

Journal of Biomaterials Applications Pub Date : 2025-04-01 Epub Date: 2025-01-05 DOI: 10.1177/08853282241312285

Niki Dadgari, Hamidreza Fotoukian, Masoumeh Haghbin Nazarpak, Mehran Solati-Hashjin

{"title":"Mechanobiological enhancement of electrospun PCL/nHA membranes for guided tissue regeneration applications.","authors":"Niki Dadgari, Hamidreza Fotoukian, Masoumeh Haghbin Nazarpak, Mehran Solati-Hashjin","doi":"10.1177/08853282241312285","DOIUrl":"10.1177/08853282241312285","url":null,"abstract":"This study aims to investigate the effects of adding nano-hydroxyapatite (nHA) to electrospun polycaprolactone (PCL) membranes for use in dental root regeneration. Porous membranes containing varying amounts of nHA (0, 1, 1.5, and 2.5 wt%) were fabricated using the electrospinning method. The physicochemical, mechanical, and biological properties of the membranes were evaluated. The synthesized nHA particles had an average size of 52 nm. Electrospun membranes exhibited uniform fibrous morphology with porosities ranging from 56% to 86%. Cyclic thermal stress (5°C-50°C) improved the mechanical properties of the composite membranes, resulting in a decrease in ultimate tensile strength (UTS) for pristine PCL from 3 ± 0.12 MPa to 1.7 ± 0.11 MPa, while the UTS for PCL membranes containing 1.5% nHA increased from 3.3 ± 0.30 MPa to 4.18 ± 0.28 MPa. In vitro bioactivity in simulated body fluid (SBF) showed enhanced apatite formation, particularly after 21 and 28 days. Cytotoxicity assays with MG-63 osteoblast-like cells demonstrated good biological performance. The incorporation of nHA not only improved the mechanical properties but also enhanced the bioactivity and cytocompatibility of the electrospun PCL membranes, making them promising candidates for guided tissue regeneration (GTR) applications.","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"1037-1054"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biodegradation study in FBS media of polycaprolactone patch as a potential prenatal treatment for myelomeningocele.

IF 2.3 4区医学

Journal of Biomaterials Applications Pub Date : 2025-04-01 Epub Date: 2025-01-29 DOI: 10.1177/08853282251316894

K Benabdderrahmane, J Stirnemann, S Ramtani, C Falentin-Daudré

{"title":"Biodegradation study in FBS media of polycaprolactone patch as a potential prenatal treatment for myelomeningocele.","authors":"K Benabdderrahmane, J Stirnemann, S Ramtani, C Falentin-Daudré","doi":"10.1177/08853282251316894","DOIUrl":"10.1177/08853282251316894","url":null,"abstract":"Myelomeningocele (MMC) is a congenital defect of the spine characterized by meningeal and spinal cord protrusion through open vertebral archs, and its exposure to the amniotic fluid. Given that the progression of neuronal loss begins early in fetal life, an early coverage of the defect is required to improve the neurological outcomes. Several studies have proposed patches as an alternative to full surgical repair, to achieve an early protection of the spine and possibly reduce the rate of complications of current prenatal surgical procedures. In our previous work, we developed a biocompatible, watertight and biodegradable patch to improve in utero MMC repair. This patch offers an anti-adhesive internal surface to prevent adhesion to spinal cord tissue, and a bioactive external surface to promote tissue coverage. The aim of this study is to assess the patch's in vitro degradation in an amniotic-fluid-like medium and investigate the surface functionalization effect, to understand its mechanism and predict the patch's behavior over time. The study was carried out for 24 weeks in FBS medium and after each period the samples were characterized by differential scanning calorimetry, scanning electron microscopy, steric exclusion chromatography, toluidine blue assay and contact angle measurement. The results revealed a progression of PCL hydrolysis over time, characterized by a decrease in molar mass and evidence of erosion as observed by SEM. Furthermore, this process appears to be accelerated by ozonation, compared to surface functionalization without ozonation. The latter can be considered as the most suitable technique to preserve the patch structure over time, while benefiting from the grafting polymers properties during the first weeks of implantation.","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"1097-1114"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human serum albumin microspheres synchronously loaded with ZIF-8 and triptolide (TP) for the treatment of intrahepatic cholangiocarcinoma.

IF 2.3 4区医学

Journal of Biomaterials Applications Pub Date : 2025-04-01 Epub Date: 2025-01-30 DOI: 10.1177/08853282251318872

Fuxin Li, Ruiqiang Cai, Zipian Ye, Li Yang, Xianshuai Qiu, Xueqiang Sun

{"title":"Human serum albumin microspheres synchronously loaded with ZIF-8 and triptolide (TP) for the treatment of intrahepatic cholangiocarcinoma.","authors":"Fuxin Li, Ruiqiang Cai, Zipian Ye, Li Yang, Xianshuai Qiu, Xueqiang Sun","doi":"10.1177/08853282251318872","DOIUrl":"10.1177/08853282251318872","url":null,"abstract":"Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver tumor and remains a fatal malignancy in most patients. Only 20% to 30% of patients can be treated with potentially curative surgical resection. Local therapies such as radioembolization and hepatic arterial perfusion may be a more effective treatment strategy. The active ingredients of natural plants have aroused wide interest in the treatment of tumors. Triptolide shows toxic effects on a variety of epithelioid carcinoma cells. However, there is currently a lack of suitable delivery system for the treatment of ICC. In this study, organometallic framework material ZIF-8 was chosen to load TP, and then encapsuled in HSA micro-nanoparticles for the perfusion treatment of ICC. The results of SEM, XRD, and FTIR showed that ZIF-8 nanoparticles were encapsuled in HSA micro-nanoparticles. ZIF-8 nanoparticles (57.89 ± 12.24%) and TP@ZIF-8/HSA (36.8 ± 4.71%) micro-nanoparticles could significantly inhibited proliferation of RBE cell. Also, TP@ZIF-8/HSA micro-nanoparticles of all groups exhibited favorable cytocompatibility to L929 cells and hemocompatibility. RT-qPCR and western blot showed that ZIF-8 and TP induced apoptosis in cancer cells through mitochondria-related pathways. The results demonstrated that TP@ZIF-8/HSA was a potential chemotherapy candidate for the treatment of ICC.","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"1030-1036"},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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