工程技术最新文献

{"title":"Correlation between coefficient of variation of blood pressure and cognitive dysfunction in patients with hypertension complicated by cerebral small vessel disease.","authors":"Xia Liu, Xuelian Zhang, Xuefen Qian, LuHang Shi, Qiaoling Liu","doi":"10.1080/02648725.2023.2204605","DOIUrl":"10.1080/02648725.2023.2204605","url":null,"abstract":"<p><p>To investigate the correlation between the coefficient of variation of blood pressure and cognitive dysfunction in patients with hypertension complicated by cerebral small vessel disease. 415 patients with hypertension complicated by cerebral small vessel disease who received treatment in our hospital from January 2019 to June 2022 were retrospectively included in this study. These patients were divided into a cognitive dysfunction group (<i>n</i> = 74) and a non-cognitive dysfunction group (<i>n</i> = 341) according to whether they had cognitive dysfunction. Blood pressure and general data were recorded for each patient. The logistic regression coefficient was used to analyze the correlation between coefficient of variation of blood pressure and cognitive dysfunction in patients with hypertension complicated by cerebral small vessel disease. Multivariate logistic regression analysis showed that age, the weighted standard deviation of 24-hour systolic blood pressure (24hSBP-wSD), cholesterol level, and triglyceride level were risk factors for cognitive dysfunction in patients with hypertension complicated by cerebral small vessel disease (<i>P</i> < 0.05). The risk for cognitive dysfunction was increased by 3.532-fold in patients aged>65 years, increased by 1.203-fold in patients with a 24hSBP-wSD of 14.9-15.9%, and increased by 3.033-fold in patients with a 24hSBP-wSD>16.0% (<i>P</i> < 0.05). The coefficient of variation of blood pressure is markedly correlated with the risk for cognitive dysfunction; and a higher coefficient of variation of blood pressure leads to a higher risk for cognitive dysfunction in patients with hypertension complicated by cerebral small vessel disease.</p>","PeriodicalId":55355,"journal":{"name":"Biotechnology & Genetic Engineering Reviews","volume":" ","pages":"3874-3883"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9768973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinicopathological significance and potential function of ULK1 in colon cancer.","authors":"Peng Lv, Zixi Wu, Lin Lai, Yukun Zhang, Bo Pei","doi":"10.1080/02648725.2023.2210952","DOIUrl":"10.1080/02648725.2023.2210952","url":null,"abstract":"<p><p>Uncoordinated 51-like kinase 1 (ULK1) is an essential part involved in autophagy to maintain cell viability and homeostasis. Herein, the expression levels of ULK1 in colon cancer (CC) were investigated, and its clinicopathological features and potential function were analyzed. Data of ULK1 were obtained from a public database. UCSC XENA RNAseq data were uniformly processed by using the Toil process. STRING was employed for identification of co-expression genes and development of PPI networks whose interaction scores exceeded 0.4. The level of immune cells for tumor infiltration was calculated by means of single-sample GSEA (ssGSEA) on the basis of mRNA data of CC. The ULK1 expression was upregulated compared with both paired and unpaired normal tissues. The mRNA expression of ULK1 was upregulated in CC patients with lymph node metastasis, lymphatic invasion, and pathological stages of 3 and 4. The disease-specific survival (DSS), progression-free interval (PFI), and the overall survival (OS) of patients with upregulated mRNA expression of ULK1 were drastically reduced. Functionally, any changes related to the biological process of ULK1 may be related to macroautophagy, autophagosome organization and autophagosome assembly. As a co-expressed gene (CEG), ATG101 was up-regulated in CC tissues and indicated poor survival. ULK1 is closely related to immune cells. ULK1 expression is upregulated in CC cells and upregulation of ULK1 may serve as an accurate prognostic factor, thereby providing novel intervention targets for therapy.</p>","PeriodicalId":55355,"journal":{"name":"Biotechnology & Genetic Engineering Reviews","volume":" ","pages":"4380-4393"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9823921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction.","authors":"","doi":"10.1080/02648725.2022.2126162","DOIUrl":"10.1080/02648725.2022.2126162","url":null,"abstract":"","PeriodicalId":55355,"journal":{"name":"Biotechnology & Genetic Engineering Reviews","volume":" ","pages":"4964"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10607613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of PM_2.5 exposure in old age and its interactive effect with smoking on incidence of diabetes.","authors":"Anthony Chen, Jiaqian Yin, Ying Ma, Jian Hou, Weiju Zhou, Zhongliang Bai, Xia Qin, Zhi Hu, Yuntao Chen, Eric J Brunner, Haidong Kan, Ruoling Chen","doi":"10.1016/j.scitotenv.2024.175219","DOIUrl":"10.1016/j.scitotenv.2024.175219","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the impact of PM_2.5 exposure in old age and its interactive effect with smoking on incident diabetes.</p><p><strong>Methods: </strong>A total of 2766 participants aged ≥60 years in China were interviewed at baseline for disease risk factors in 2001-03 and were then followed up for 10 years to document incident diabetes. They were assessed for daily PM_2.5 exposure in 2005. Multivariate Cox regression models were used to examine the association of PM_2.5 exposure with incident diabetes and interactive effect between PM_2.5 and smoking on incident diabetes.</p><p><strong>Results: </strong>During the cohort follow-up, 176 participants developed diabetes. The incidence of diabetes increased with PM_2.5 exposure; the multiple-adjusted hazard ratio (HR) of diabetes was 2.27 (95 % CI 1.36-3.77) in participants with PM_2.5 at ≥62.0 μg/m³ compared to those at <62.0 μg/m³. There was a significant interaction effect of PM_2.5 with smoking on increased risk of diabetes. The adjusted HR for participants exposed to PM_2.5 levels ≥62.0 μg/m³ who smoked was 4.39 (95 % CI 1.72-11.21), while for non-smokers it was 1.65 (95 % CI 0.88-3.09), compared to those at <62.0 μg/m³.</p><p><strong>Conclusions: </strong>Exposure to PM_2.5 in old age was associated with an increased incidence of diabetes and smoking enhanced the impact of PM_2.5 on diabetic risk. These findings underscore the urgent need for air quality improvement measures and smoking cessation programs to mitigate the risk of diabetes in aging populations.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"175219"},"PeriodicalIF":5.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141887998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective phthalate removal by molecularly imprinted biomass carbon modified electro-Fenton cathode.","authors":"Mengyao Liu, Shenbao Qu, Hongdi Mou, Man Wei, Xia Hu, Aijiang Yang","doi":"10.1016/j.biortech.2024.131548","DOIUrl":"10.1016/j.biortech.2024.131548","url":null,"abstract":"<p><p>A novel molecularly imprinted biomass carbon (MIP@BC) catalyst functionalized with the virtual template of phthalates was designed as the cathode material which possesses excellent 2-electron oxygen reduction ability and H₂O₂ production capacity, which is suitable for targeted degradation of phthalates in the electro-Fenton system. Following molecularly imprinted modification, the adsorption capacity of MIP@BC for Dimethyl phthalate (DMP) increased by 40 %, reached 9.26 mg/g. Compared with non-imprinted biomass carbon (NIP@BC), the MIP@BC-mediated electro-Fenton process enhanced the degradation rate of DMP by 72 %. Additionally, the degradation rate of DMP rises by 51 % and 104 % respectively on the basis of river water and domestic sewage. The reactive oxygen species that induced DMP degradation were OH and O₂^- and targeted adsorption and catalysis exert a synergistic effect. This study provides a new insight into targeted degradation for high-toxicity of emerging contaminants from complex aqueous environment.</p>","PeriodicalId":9,"journal":{"name":"ACS Catalysis ","volume":" ","pages":"131548"},"PeriodicalIF":9.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142338134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prenatal assimilation of minerals and metals in nestlings of a small passerine bird.","authors":"Grzegorz Orłowski, Lucyna Hałupka, Przemysław Pokorny, Bartosz Borczyk, Tomasz Skawiński, Wojciech Dobicki","doi":"10.1016/j.scitotenv.2024.176437","DOIUrl":"10.1016/j.scitotenv.2024.176437","url":null,"abstract":"<p><p>Although certain metals can reach their highest concentrations in tissues of newly hatched nestlings, their sources have yet to be fully elucidated. Evidence for the differentiation of body reserves, including some chemical elements, during avian embryonic life and early post-hatching period is limited mostly to studies on poultry. Here, we present novel findings on the bioaccumulation and egg-to-nestling transfer of 10 minerals and metals, including non-essential potentially toxic chemical elements (Cu, Ni Cd, Pb, Zn, Ag, Mg, Fe, Co and Ca) in the tissues of the gastrointestinal tract (GT), whole body (WB) and carcass (CA) of nestlings of a small passerine bird, the Eurasian Reed Warbler Acrocephalus scirpaceus, breeding in an intensively fertilized fishpond habitat. Our findings show that concentrations of metals that are relevant to contaminated systems (Cu, Ni, Cd, Pb, Zn, Fe and Co) are the highest in GT tissues across all the nestling age classes examined (from hatching to day 9 of life). The important question emerged from our findings: why the hatchlings were characterized by higher metal concentrations in GT, WB and CA compared to older nestlings. We suggest that the prenatal accumulation of chemical elements assimilated from egg contents, and their subsequent utilization for building various tissues/internal organs by the growing embryo, is a reasonable explanation for this finding. More specifically, the potential functional mechanism explaining the highest concentrations of some trace metals in hatchlings seems to be associated with an extremely high rate of utilization of residual yolk metal resources that survived from the embryonic until the post-natal period. On the basis of our own work and literature data, we identified a presumable significant discrepancy in the actual rate of egg-to-nestling and egg-to-embryo metal transfer due to the eggshell being ignored (a commonly occurrence), and only the egg contents being treated as the basic repository of chemical elements for developing embryos. Much more research is needed on the prenatal assimilation and subsequent accumulation of chemical elements in a developing avian embryo, representing both the transition from near-to-hatching embryos to hatchlings, and then to older nestlings.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"176437"},"PeriodicalIF":5.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142338595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative distribution of antibiotic resistance genes and crAssphage in a tropical urbanized watershed.","authors":"Montakarn Sresung, Thitima Srathongneam, Phongsawat Paisantham, Rojana Sukchawalit, Wirongrong Whangsuk, Ryo Honda, Jutamaad Satayavivad, Skorn Mongkolsuk, Kwanrawee Sirikanchana","doi":"10.1016/j.scitotenv.2024.176569","DOIUrl":"10.1016/j.scitotenv.2024.176569","url":null,"abstract":"<p><p>As antimicrobial resistance continues to pose a significant threat to global health, this study provided a focused examination of the prevalence and behavior of key antibiotic resistance genes in aquatic environments. We investigated the quantitative distribution of intI1, sul1, bla_TEM, bla_NDM, bla_VIM, mcr-1, tetQ, and crAssphage within wastewater influents (n = 12), effluents (n = 12) and river water samples (n = 12), from three municipal wastewater treatment plants and three river locations in an urbanized watershed in Central Thailand over dry and wet seasons. The qPCR method demonstrated that intI1, sul1, bla_TEM, and tetQ were the most abundant in all samples (2.71-7.89 mean log₁₀ copies/100 mL), with all genes exhibiting consistently uniform levels across diverse locations, suggesting the potential for any site to act as a monitoring sentinel. Although there is a significant reduction of ARG concentrations by WWTPs (0.62 - >4.05 LRV), the persistence of these genes in effluents points to the limited effectiveness of existing treatment methodologies. Temporal data indicated stable ARG concentrations over time, but tetQ levels rose during the wet season, in alignment with the monsoonal climate in Thailand. Additionally, we identified crAssphage, a marker of human sewage contamination, exhibited strong correlations with the more abundant ARGs (rho 0.65 - 0.81), implying that human waste contributes significantly to the environmental burden of ARGs. The results of this research highlight the widespread nature of ARGs in water systems and the need for improved treatment and sanitation strategies to mitigate the public health threat posed by antimicrobial resistance.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"176569"},"PeriodicalIF":5.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142338658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parabens as the double-edged sword: Understanding the benefits and potential health risks.","authors":"Sovona Chatterjee, Satadal Adhikary, Suchandra Bhattacharya, Aritra Chakraborty, Sohini Dutta, Dipsikha Roy, Abhratanu Ganguly, Sayantani Nanda, Prem Rajak","doi":"10.1016/j.scitotenv.2024.176547","DOIUrl":"10.1016/j.scitotenv.2024.176547","url":null,"abstract":"<p><p>Parabens are globally employed as important preservatives in pharmaceutical, food, and personal care products. Nonetheless, improper disposal of commercial products comprising parabens can potentially contaminate various environmental components, including the soil and water. Residues of parabens have been detected in surface water, ground water, packaged food materials, and other consumer items. Long-term exposure to parabens through numerous consumer products and contaminated water can harm human health. Paraben can modulate the hormonal and immune orchestra of the body. Recent findings have correlated paraben use with hypersensitivity, obesity, and infertility. Notably, parabens have also been detected in the samples of breast cancer patients, suggesting a potential cross-talk between parabens and carcinogenesis. Therefore, the present article aims to dissect the significance of parabens as a preservative in several consumer products and their impact of chronic exposure to human health. This review encompasses various facets of paraben, including its sources, mechanism of action at the molecular level, and sheds light on its toxicological implications on human health.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"176547"},"PeriodicalIF":5.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142363869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacillus thuringiensis (Bt)-based biopesticide: Navigating success, challenges, and future horizons in sustainable pest control.","authors":"M Ragasruthi, N Balakrishnan, M Murugan, N Swarnakumari, S Harish, D Jeya Sundara Sharmila","doi":"10.1016/j.scitotenv.2024.176594","DOIUrl":"10.1016/j.scitotenv.2024.176594","url":null,"abstract":"<p><p>The global demand for food production is escalating, necessitating innovative approaches to mitigate pest-related crop losses. Conventional pest management using synthetic pesticides has several drawbacks, promoting the search for eco-friendly alternatives such as biopesticides. Among these, Bacillus thuringiensis (Bt)-based biopesticides have emerged as a promising option due to their specificity, sustainability, and safety. This article reviews the success and application of Bt as a biopesticide, analysing its environmental impacts, formulation strategies, marketing trends and associated challenges. The environment impact of Bt is multifaceted, influencing soil ecosystems, plant-associated habitats, and non-target organisms. It interacts dynamically with soil invertebrates and affects both aquatic and terrestrial ecosystems, demonstrating a complex ecological footprint. The market for Bt-based biopesticide is expanding, driven by their proven efficacy and eco-friendliness with projections indicating continued growth. Despite the promising market trends, regulatory hurdles and formulation complexities remain significant obstacles. Addressing these challenges require collaborative efforts to streamline processes and enhance market acceptance. Nonetheless, the future of Bt-based biopesticide appears promising. Ongoing research is focused on advanced formulations, expanding the range of targeted pests and fostering regulatory cooperation, underscoring the pivotal role of Bt-based biopesticide in sustainable agriculture.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"176594"},"PeriodicalIF":5.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142363786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distribution of tetracyclines and sulfonamides resistance genes around a smallholder pig farm: Modeling and attribution.","authors":"Haofei Li, Zishu Liu, Baolan Hu, Lizhong Zhu","doi":"10.1016/j.scitotenv.2024.176618","DOIUrl":"10.1016/j.scitotenv.2024.176618","url":null,"abstract":"<p><p>Livestock farm is a major source of antibiotics and antibiotic resistance genes (ARGs) pollution. ARGs can directly enter the environment through runoff and air deposition. The impact extent and the driving factors require further investigation to inform effective policies and actions to mitigate their spread. This study investigated a smallholder pig farm and its surrounding areas to understand the spread of ARGs. Topsoil samples were collected from 56 different sites within one kilometer of the farm, and a comprehensive analysis was conducted to reveal effects of soil properties, antibiotic residues, microbiome, mobilome on the variation of typical ARGs. The results confirmed that the ARGs reduced exponentially with increasing distance from the farm, with a goodness of fit (R²) of 0.7 for total ARGs. For tetracyclines (TC) and sulfonamides (SA) resistance genes, the fitting R² exceeded 0.9. Model estimates allowed for quantitative comparisons of in-farm increments, out-farm background levels, and spread abilities of ARGs with distinct resistance mechanisms. SA-specific resistance genes (SRGs, 0.097 copies/16S rRNA gene) and TC-specific resistance genes (TRGs, 0.036 copies/16S rRNA gene) showed higher within-farm increases compared to multidrug resistance genes (MDRGs, 0.020 copies/16S rRNA gene). MDRGs, however, had a higher background level and a greater impact distance (0.18 km, 4.4 times the farm radius). Additionally spread abilities of TRGs varied by resistance mechanism, with ribosome protection proteins showing greater spread than TC inactivating enzymes and TC efflux pumps, likely due to different fitness costs. Correlation analysis and structural equation modeling indicated that changes in bacterial community composition and mobilome are primary factors influencing ARGs variation during their spread. Abiotic factors like soil nutrients and antibiotics also selectively enriched ARGs within the farm. These findings provide insights into the ARGs dissemination and could inform strategies to prevent their spread from smallholder livestock farms.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"176618"},"PeriodicalIF":5.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142363850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}