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A novel predefined-time projective synchronization strategy for multi-modal memristive neural networks. 一种新的多模态记忆神经网络的预定义时间投影同步策略。
IF 3.1 3区 工程技术
Cognitive Neurodynamics Pub Date : 2025-12-01 Epub Date: 2025-03-15 DOI: 10.1007/s11571-025-10234-0
Hui Zhao, Lei Zhou, Aidi Liu, Sijie Niu, Xizhan Gao, Xiju Zong, Xin Li, Lixiang Li
{"title":"A novel predefined-time projective synchronization strategy for multi-modal memristive neural networks.","authors":"Hui Zhao, Lei Zhou, Aidi Liu, Sijie Niu, Xizhan Gao, Xiju Zong, Xin Li, Lixiang Li","doi":"10.1007/s11571-025-10234-0","DOIUrl":"10.1007/s11571-025-10234-0","url":null,"abstract":"<p><p>Due to its complexity, the problem of predefined-time synchronization in multimodal memristive neural networks has rarely been explored in the literature. This paper is the first to systematically study this issue, filling a research gap in the field and further enriching the related theoretical framework. First, a novel predefined-time stability theorem is proposed, which features more lenient judgment conditions compared to existing methods. This significantly enhances the generality of the stability theorem, making it applicable to a wider range of practical engineering projects. Second, based on the proposed predefined-time stability theorem, as well as the theories of differential inclusion, Filippov solutions, and set-valued mapping, a simple and practical feedback controller is developed. This controller establishes the necessary criteria for achieving predefined-time projective synchronization in multimodal memristive neural networks. Finally, two intricate simulation experiments are carefully designed. These experiments validate the effectiveness and feasibility of the theoretical derivations presented in this paper.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"19 1","pages":"50"},"PeriodicalIF":3.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Focal attention peaks and laterality bias in problem gamblers: an eye-tracking investigation. 问题赌徒的注意力峰值和偏侧性:一项眼动追踪调查。
IF 3.1 3区 工程技术
Cognitive Neurodynamics Pub Date : 2025-12-01 Epub Date: 2025-03-22 DOI: 10.1007/s11571-025-10238-w
Yayoi Shigemune, Akira Midorikawa
{"title":"Focal attention peaks and laterality bias in problem gamblers: an eye-tracking investigation.","authors":"Yayoi Shigemune, Akira Midorikawa","doi":"10.1007/s11571-025-10238-w","DOIUrl":"10.1007/s11571-025-10238-w","url":null,"abstract":"<p><p>Problem gambling has been associated with attentional biases toward gambling-related stimuli, but less is known about how problem gamblers distribute their visual attention during gambling tasks. This eye-tracking study investigated differences in sustained visual attention between problem gamblers (PGs; <i>n</i> = 22) and non-problem gamblers (NPGs; <i>n</i> = 22) during a gambling task using neutral picture pairs. While total gaze time toward stimuli did not differ between the groups, PGs showed distinctive characteristics in their visual attentional allocation. Specifically, two-sample <i>t</i>-tests revealed that PGs exhibited significantly higher focal attention to right-sided stimuli in central zones (0-25 pixels) during decision-making, while NPGs demonstrated greater left-sided peripheral attention (76-100 pixels) during feedback. These patterns were further supported by a three-way ANOVA showing a significant group × zone × laterality interaction in the decision phase, confirming that PGs exhibited significantly higher right-sided attention in the central zone (0-25 and 26-50 pixels), while NPGs showed a tendency toward greater left-sided attention in the peripheral zone (76-100 pixels). Additionally, PGs demonstrated stronger rightward attentional bias in both phases. These differences in visual attention were associated with higher behavioral-approach-system, reward sensitivity, and sensation-seeking scores among PGs. The findings suggest that PGs exhibit distinctive characteristics in terms of sustained visual attention during gambling-related decision-making, even when viewing neutral stimuli. This distinctive distribution of visual attention may reflect fundamental differences in information processing and potential hemispheric imbalances in attention control mechanisms among PGs.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"19 1","pages":"51"},"PeriodicalIF":3.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shared neural dynamics of facial expression processing. 面部表情处理的共享神经动力学。
IF 3.1 3区 工程技术
Cognitive Neurodynamics Pub Date : 2025-12-01 Epub Date: 2025-03-04 DOI: 10.1007/s11571-025-10230-4
Madeline Molly Ely, Géza Gergely Ambrus
{"title":"Shared neural dynamics of facial expression processing.","authors":"Madeline Molly Ely, Géza Gergely Ambrus","doi":"10.1007/s11571-025-10230-4","DOIUrl":"10.1007/s11571-025-10230-4","url":null,"abstract":"<p><p>The ability to recognize and interpret facial expressions is fundamental to human social cognition, enabling navigation of complex interpersonal interactions and understanding of others' emotional states. The extent to which neural patterns associated with facial expression processing are shared between observers remains unexplored, and no study has yet examined the neural dynamics specific to different emotional expressions. Additionally, the neural processing dynamics of facial attributes such as sex and identity in relation to facial expressions have not been thoroughly investigated. In this study, we investigated the shared neural dynamics of emotional face processing using an explicit facial emotion recognition task, where participants made two-alternative forced choice (2AFC) decisions on the displayed emotion. Our data-driven approach employed cross-participant multivariate classification and representational dissimilarity analysis on EEG data. The results demonstrate that EEG signals can effectively decode the sex, emotional expression, and identity of face stimuli across different stimuli and participants, indicating shared neural codes for facial expression processing. Multivariate classification analyses revealed that sex is decoded first, followed by identity, and then emotion. Emotional expressions (angry, happy, sad) were decoded earlier when contrasted with neutral expressions. While identity and sex information were modulated by image-level stimulus features, the effects of emotion were independent of visual image properties. Importantly, our findings suggest enhanced processing of face identity and sex for emotional expressions, particularly for angry faces and, to a lesser extent, happy faces.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s11571-025-10230-4.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"19 1","pages":"45"},"PeriodicalIF":3.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reciprocal causation relationship between rumination thinking and sleep quality: a resting-state fMRI study. 反刍思维与睡眠质量的因果关系:静息状态fMRI研究。
IF 3.1 3区 工程技术
Cognitive Neurodynamics Pub Date : 2025-12-01 Epub Date: 2025-02-20 DOI: 10.1007/s11571-025-10223-3
Shiyan Yang, Xu Lei
{"title":"Reciprocal causation relationship between rumination thinking and sleep quality: a resting-state fMRI study.","authors":"Shiyan Yang, Xu Lei","doi":"10.1007/s11571-025-10223-3","DOIUrl":"10.1007/s11571-025-10223-3","url":null,"abstract":"<p><p>Rumination thinking is a type of negative repetitive thinking, a tendency to constantly focus on the causes, consequences and other aspects of negative events, which has implications for a variety of psychiatric disorders. Previous studies have confirmed a strong association between rumination thinking and poor sleep or insomnia, but the direction of causality between the two is not entirely clear. This study examined the relationship between rumination thinking and sleep quality using a longitudinal approach and resting-state functional MRI data. Participants were 373 university students (males: <i>n</i> = 84, 18.67 ± 0.76 years old) who completed questionnaires at two time points (T1 and T2) and had resting-state MRI data collected. The results of the cross-lagged model analysis revealed a bidirectional causal relationship between rumination thinking and sleep quality. Additionally, the functional connectivity (FC) of the precuneus and lingual gyrus was found to be negatively correlated with rumination thinking and sleep quality. Furthermore, mediation analysis showed that rumination thinking at T1 fully mediated the relationship between FC of the precuneus-lingual and sleep quality at T2. These findings suggest that rumination thinking and sleep quality are causally related in a bidirectional manner and that the FC of the precuneus and lingual gyrus may serve as the neural basis for rumination thinking to predict sleep quality. Overall, this study provides new insights for enhancing sleep quality and promoting overall health.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s11571-025-10223-3.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"19 1","pages":"41"},"PeriodicalIF":3.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cross-subject mental workload recognition using bi-classifier domain adversarial learning. 基于双分类器领域对抗学习的跨学科心理工作量识别。
IF 3.1 3区 工程技术
Cognitive Neurodynamics Pub Date : 2025-12-01 Epub Date: 2025-01-09 DOI: 10.1007/s11571-024-10215-9
Yueying Zhou, Pengpai Wang, Peiliang Gong, Peng Wan, Xuyun Wen, Daoqiang Zhang
{"title":"Cross-subject mental workload recognition using bi-classifier domain adversarial learning.","authors":"Yueying Zhou, Pengpai Wang, Peiliang Gong, Peng Wan, Xuyun Wen, Daoqiang Zhang","doi":"10.1007/s11571-024-10215-9","DOIUrl":"10.1007/s11571-024-10215-9","url":null,"abstract":"<p><p>To deploy Electroencephalogram (EEG) based Mental Workload Recognition (MWR) systems in the real world, it is crucial to develop general models that can be applied across subjects. Previous studies have utilized domain adaptation to mitigate inter-subject discrepancies in EEG data distributions. However, they have focused on reducing global domain discrepancy, while neglecting local workload-categorical domain divergence. This degrades the workload-discriminating ability of subject-invariant features. To deal with this problem, we propose a novel joint category-wise and domain-wise alignment Domain Adaptation (cdaDA) algorithm, using bi-classifier learning and domain discriminative adversarial learning. The bi-classifier learning approach is adopted to address the similarities and differences between categories, helping to align EEG data within the same mental workload categories. Additionally, the domain discriminative adversarial learning technique is adopted to consider global domain information by minimizing global domain discrepancy. By integrating both local category information and global domain information, the cdaDA model performs a coarse-to-fine alignment and achieves promising cross-subject MWR results.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"19 1","pages":"16"},"PeriodicalIF":3.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monitoring nap deprivation-induced fatigue using fNIRS and deep learning. 利用近红外光谱和深度学习监测午睡剥夺引起的疲劳。
IF 3.1 3区 工程技术
Cognitive Neurodynamics Pub Date : 2025-12-01 Epub Date: 2025-01-23 DOI: 10.1007/s11571-025-10219-z
Pei Ma, Chenyang Pan, Huijuan Shen, Wushuang Shen, Hui Chen, Xuedian Zhang, Shuyu Xu, Jingzhou Xu, Tong Su
{"title":"Monitoring nap deprivation-induced fatigue using fNIRS and deep learning.","authors":"Pei Ma, Chenyang Pan, Huijuan Shen, Wushuang Shen, Hui Chen, Xuedian Zhang, Shuyu Xu, Jingzhou Xu, Tong Su","doi":"10.1007/s11571-025-10219-z","DOIUrl":"10.1007/s11571-025-10219-z","url":null,"abstract":"<p><p>Fatigue-induced incidents in transportation, aerospace, military, and other areas have been on the rise, posing a threat to human life and safety. The determination of fatigue states holds significant importance, especially through reliable and conveniently available physiological indicators. Here, a portable custom-built fNIRS system was used to monitor the fatigue state caused by nap deprivation. fNIRS signals in ten channels at the prefrontal cortex were collected, changes in blood oxygen concentration were analyzed, followed by a deep learning model to classify fatigue states. For the high-dimensionality and multi-channel characteristics of the fNIRS signal data, a novel 1D revised CNN-ResNet network was proposed based on the double-layer channel attenuation residual block. The results showed a 97.78% accuracy in fatigue state classification, significantly superior than several conventional methods. Furthermore, a fatigue-arousal experiment was designed to explore the feasibility of forced arousal of fatigued subjects through exercise stimulation. The fNIRS results showed a significant increase in brain activity with the conduction of exercise. The proposed method serves as a reliable tool for the evaluation of fatigue states, potentially reducing fatigue-induced harms and risks.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"19 1","pages":"30"},"PeriodicalIF":3.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11757655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vivo toxicity of chitosan-based nanoparticles: a systematic review. 壳聚糖基纳米颗粒的体内毒性:系统综述。
IF 4.5 3区 生物学
Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-02-09 DOI: 10.1080/21691401.2025.2462328
Shela Salsabila, Miski Aghnia Khairinisa, Nasrul Wathoni, Irna Sufiawati, Wan Ezumi Mohd Fuad, Nur Kusaira Khairul Ikram, Muchtaridi Muchtaridi
{"title":"<i>In vivo</i> toxicity of chitosan-based nanoparticles: a systematic review.","authors":"Shela Salsabila, Miski Aghnia Khairinisa, Nasrul Wathoni, Irna Sufiawati, Wan Ezumi Mohd Fuad, Nur Kusaira Khairul Ikram, Muchtaridi Muchtaridi","doi":"10.1080/21691401.2025.2462328","DOIUrl":"10.1080/21691401.2025.2462328","url":null,"abstract":"<p><p>Chitosan nanoparticles have been extensively utilised as polymeric drug carriers in nanoparticles formulations due to their potential to enhance drug delivery, efficacy, and safety. Numerous toxicity studies have been previously conducted to assess the safety profile of chitosan-based nanoparticles. These toxicity studies employed various methodologies, including test animals, interventions, and different routes of administration. This review aims to summarise research on the safety profile of chitosan-based nanoparticles in drug delivery, with a focus on general toxicity tests to determine LD50 and NOAEL values. It can serve as a repository and reference for chitosan-based nanoparticles, facilitating future research and further development of drugs delivery system using chitosan nanoparticles. Publications from 2014 to 2024 were obtained from PubMed, Scopus, Google Scholar, and ScienceDirect, in accordance with the inclusion and exclusion criteria.The ARRIVE 2.0 guidelines were employed to evaluate the quality and risk-of-bias in the <i>in vivo</i> toxicity studies. The results demonstrated favourable toxicity profiles, often exhibiting reduced toxicity compared to free drugs or substances. Acute toxicity studies consistently reported high LD50 values, frequently exceeding 5000 mg/kg body weight, while subacute studies typically revealed no significant adverse effects. Various routes of administration varied, including oral, intravenous, intraperitoneal, inhalation, and topical, each demonstrating promising safety profiles.</p>","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"53 1","pages":"1-15"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vitamin D3 loaded polycaprolactone nanoparticles enhance the expression of the antimicrobial peptide cathelicidin in macrophages. 维生素D3负载的聚己内酯纳米颗粒增强巨噬细胞中抗菌肽抗菌肽的表达。
IF 4.5 3区 生物学
Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-05-06 DOI: 10.1080/21691401.2025.2499515
Prince N Dlozi, Rami Ahmed, Star Khoza, Admire Dube
{"title":"Vitamin D3 loaded polycaprolactone nanoparticles enhance the expression of the antimicrobial peptide cathelicidin in macrophages.","authors":"Prince N Dlozi, Rami Ahmed, Star Khoza, Admire Dube","doi":"10.1080/21691401.2025.2499515","DOIUrl":"https://doi.org/10.1080/21691401.2025.2499515","url":null,"abstract":"<p><p>Tuberculosis (TB), primarily caused by <i>Mycobacterium tuberculosis</i>, remains a global health burden. Current antibiotic treatments are limited by adverse effects, poor adherence, and drug resistance, necessitating new therapeutic approaches. Recent studies highlight the role of vitamin D3 (VD3) in enhancing host immune responses against the mycobacterium <i>via</i> cathelicidin (an antimicrobial peptide) and autophagy activation. In this study, VD3-loaded poly-ƹ-caprolactone (PCL) nanoparticles (NPs) were synthesized to enhance cathelicidin expression in macrophages. NPs containing cholecalciferol, calcifediol, and calcitriol were synthesized using an emulsification solvent-evaporation technique. Average sizes of synthesized NPs ranged from 304.7 to 458.7 nm, with polydispersity index (PDI) and zeta potential (ZP) ranging from 0.103 to 0.257 and -17.3 to -7.47 mV, respectively. Encapsulation efficiencies were 9.68%, 10.99%, and 19.28% for cholecalciferol, calcifediol, and calcitriol, respectively. VD3-encapsulated NPs stimulated a dose-dependent increase in cathelicidin expression in THP-1 macrophages. Encapsulated calcifediol and calcitriol (100 ng/ml) induced the expression of 243.46 ng/ml ± 4.55 ng/ml and 396.67 ng/ml ± 25.24 ng/ml of cathelicidin, respectively, which was significantly higher than that induced by the free drugs. These findings suggest that NP encapsulation may offer a more efficient approach to using vitamin D3 for inducing cathelicidin expression as a host-directed treatment for TB.</p>","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"53 1","pages":"207-219"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antiparasitic and antimicrobial activity of Ipomoea palmata against Toxoplasma gondii and Staphylococcus aureus: correlation with major phenolics identified by HPLC. 棕榈木对刚地弓形虫和金黄色葡萄球菌的抗寄生和抗菌活性:与HPLC鉴定的主要酚类物质的相关性。
IF 4.5 3区 生物学
Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-04-26 DOI: 10.1080/21691401.2025.2494796
Amira Mira, Tariq M Aljarba, Fatma M Abdel Bar, Rehab Ahmed, Walaa A Negm, Engy Elekhnawy, Hosam M El-Seadawy, Eman A Elmorsy, Salwa S Younis
{"title":"Antiparasitic and antimicrobial activity of <i>Ipomoea palmata</i> against <i>Toxoplasma gondii</i> and <i>Staphylococcus aureus</i>: correlation with major phenolics identified by HPLC.","authors":"Amira Mira, Tariq M Aljarba, Fatma M Abdel Bar, Rehab Ahmed, Walaa A Negm, Engy Elekhnawy, Hosam M El-Seadawy, Eman A Elmorsy, Salwa S Younis","doi":"10.1080/21691401.2025.2494796","DOIUrl":"https://doi.org/10.1080/21691401.2025.2494796","url":null,"abstract":"<p><p><i>Toxoplasma gondii</i>, a protozoan parasite found in water sources, causes toxoplasmosis, with no current protocols for inactivating its oocysts in water. <i>Staphylococcus aureus</i>, a significant bacterial pathogen, is known for causing various illnesses, including skin infections and biofilm-related diseases. This study investigated the antibacterial and antiparasitic properties of <i>Ipomoea palmata</i> leaf extract, rich in phenolics, against <i>T. gondii</i> tachyzoites and <i>S. aureus. I. palmata</i> extract significantly reduced tachyzoites count in peritoneal fluids and liver smears of infected mice with alleviation of toxoplasmosis-induced hepatitis. SEM showed surface irregularities in tachyzoites from treated groups. The extract demonstrated antibacterial action against <i>S. aureus</i> with a minimum inhibitory concentration of 128 to 512 <i>µ</i>g/mL, reduced biofilm formation from 69.23% to 15.38% of tested isolates, and downregulated biofilm genes (<i>cna</i>, <i>fnbA</i>, and <i>ica</i>) in 53.85% of isolates. Treatment with <i>I. palmata</i> extract improved liver architecture, reduced inflammation, and eliminated blood vessel congestion. The main phenolic acids identified by HPLC/UV analysis were chlorogenic acid, gallic acid, ellagic acid, and methyl gallate, while the predominant flavonoids were apigenin, quercetin, and naringenin. These findings highlight the potential of <i>I. palmata</i> extract as a natural antimicrobial and antiparasitic agent, warranting further research to isolate and evaluate its active compounds.</p>","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"53 1","pages":"194-206"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EEG microstate biomarkers for schizophrenia: a novel approach using deep neural networks. 精神分裂症的EEG微状态生物标志物:一种使用深度神经网络的新方法。
IF 3.1 3区 工程技术
Cognitive Neurodynamics Pub Date : 2025-12-01 Epub Date: 2025-05-03 DOI: 10.1007/s11571-025-10251-z
Zahra Raeisi, Omid Bashiri, MohammadReza EskandariNasab, Mahdi Arshadi, Alireza Golkarieh, Hossein Najafzadeh
{"title":"EEG microstate biomarkers for schizophrenia: a novel approach using deep neural networks.","authors":"Zahra Raeisi, Omid Bashiri, MohammadReza EskandariNasab, Mahdi Arshadi, Alireza Golkarieh, Hossein Najafzadeh","doi":"10.1007/s11571-025-10251-z","DOIUrl":"https://doi.org/10.1007/s11571-025-10251-z","url":null,"abstract":"<p><p>Schizophrenia remains a challenging neuropsychiatric disorder with complex diagnostic processes. Current clinical approaches often rely on subjective assessments, highlighting the critical need for objective, quantitative diagnostic methods. This study aimed to develop a robust classification approach for schizophrenia using EEG microstate analysis and advanced machine learning techniques. We analyzed EEG signals from 14 healthy individuals and 14 patients with schizophrenia during a 15-min resting-state session across 19 EEG channels. A data augmentation strategy expanded the dataset to 56 subjects in each group. The signals were preprocessed and segmented into five frequency bands (delta, theta, alpha, beta, gamma) and five microstates (A, B, C, D, E) using k-means clustering. Five key features were extracted from each microstate: duration, occurrence, standard deviation, coverage, and frequency. A Deep Neural Network (DNN) model, along with other machine learning classifiers, was developed to classify the data. A comprehensive fivefold cross-validation approach evaluated model performance across various EEG channels, frequency bands, and feature combinations. Significant alterations in microstate transition probabilities were observed, particularly in higher frequency bands. The gamma band showed the most pronounced differences, with a notable disruption in D → A transitions (absolute difference = 0.100). The Random Forest classifier achieved the highest accuracy of 99.94% ± 0.12%, utilizing theta band features from the F8 frontal channel. The deep neural network model demonstrated robust performance with 98.31% ± 0.68% accuracy, primarily in the occipital region. Feature size 2 consistently provided optimal classification across most models. Our study introduces a novel, high-precision EEG microstate analysis approach for schizophrenia diagnosis, offering an objective diagnostic tool with potential applications in neuropsychiatric disorders. The findings reveal critical insights into neural dynamics associated with schizophrenia, demonstrating the potential for transforming clinical diagnostic practices through advanced machine learning and neurophysiological feature extraction.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"19 1","pages":"68"},"PeriodicalIF":3.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12049357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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