Advanced Healthcare Materials最新文献

Scaffold-Hydrogel Synergy with OPC-Crosslinked dUECM and VEGF-Nanocomposite Hydrogel Achieves Dual "Structural-Vascular" Regeneration in Rats. 支架水凝胶与opc交联dUECM和vegf纳米复合水凝胶协同作用在大鼠中实现双重“结构-血管”再生。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-10-19 DOI: 10.1002/adhm.71863

Xinji Wang, Qin Gu, Yijia Zhang, Yujie Wu, Dedong Yu, Yingnan Xiao, Huizhe Chen, Xiehua Pan, Deli Zhuge, Yingzheng Zhao

{"title":"Scaffold-Hydrogel Synergy with OPC-Crosslinked dUECM and VEGF-Nanocomposite Hydrogel Achieves Dual \"Structural-Vascular\" Regeneration in Rats.","authors":"Xinji Wang, Qin Gu, Yijia Zhang, Yujie Wu, Dedong Yu, Yingnan Xiao, Huizhe Chen, Xiehua Pan, Deli Zhuge, Yingzheng Zhao","doi":"10.1002/adhm.71863","DOIUrl":"https://doi.org/10.1002/adhm.71863","url":null,"abstract":"Absolute uterine factor infertility (AUFI) remains untreatable with current assisted reproduction techniques. Although decellularized uterine extracellular matrix (dUECM) holds promise for uterine reconstruction, its clinical translation is limited by rapid degradation and poor angiogenic capacity. Herein, a dual-component system was developed by combining oligomeric proanthocyanidin (OPC)-crosslinked dUECM with an injectable VEGF-loaded nanocomposite hydrogel. The OPC-dUECM scaffold (1 mg/mL OPC solution) restored native-like tensile strength, reduced collagenase-induced degradation to 52%, and facilitated cellular infiltration. The VEGF-EPL-HP nanocomposite hydrogel was fabricated by encapsulating VEGF (350 ng/mL) in ε-polylysine/heparin-poloxamer (EPL-HP) nanoparticles dispersed within a thermosensitive hydrogel. The hydrogel exhibited a gelation temperature of 23.2°C, provided sustained VEGF release over 7 days, and showed negligible hemolytic toxicity. In vitro, this hydrogel significantly enhanced the migration and tube formation of human umbilical vein endothelial cells. At 90 days post-surgery in a rat uterine defect model, the combined OPC-dUECM + VEGF-EPL-HP group achieved full endometrial and myometrial regeneration, accompanied by elevated microvessel density, attenuated inflammation, and negligible fibrotic lesions. Collectively, this study validated a synergistic scaffold-hydrogel platform enabling concurrent structural reconstruction and vascularization of the injured uterus, offering a clinically translatable strategy for AUFI patients.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71863"},"PeriodicalIF":11.0,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149222878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pandemic-Responsive Molecularly Imprinted Polymer-Based Electrochemical Sensor for Mpox Detection. 基于分子印迹聚合物的m痘检测电化学传感器。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-10-19 DOI: 10.1002/adhm.71847

Youngjun Seo, Yonghwan Kim, Jaeheung Kim, Jae Won Jang, Hyo Gi Jung, Dongsung Park, Yonghoon Shin, Hongrae Kim, Yeon Ho Kim, Junho Bang, Hyunji Kim, Jeong Hoon Lee, Dongtak Lee, Kyo Seon Hwang, Dae Sung Yoon

{"title":"Pandemic-Responsive Molecularly Imprinted Polymer-Based Electrochemical Sensor for Mpox Detection.","authors":"Youngjun Seo, Yonghwan Kim, Jaeheung Kim, Jae Won Jang, Hyo Gi Jung, Dongsung Park, Yonghoon Shin, Hongrae Kim, Yeon Ho Kim, Junho Bang, Hyunji Kim, Jeong Hoon Lee, Dongtak Lee, Kyo Seon Hwang, Dae Sung Yoon","doi":"10.1002/adhm.71847","DOIUrl":"https://doi.org/10.1002/adhm.71847","url":null,"abstract":"In 2022, a global Mpox outbreak occurred, and the World Health Organization (WHO) declared it a Public Health Emergency of International Concern (PHEIC). Although the outbreak was quickly constrained, new cases of infection associated with mutated virions continue to be documented worldwide. In recent global health crises, there is an urgent need to develop rapid, cost-effective diagnostic assays. While nucleic acid assays (e.g., PCR and CRISPR-based methods) represent the current gold standard for Mpox virus (MPXV) detection, point-of-care (POC) assays for Mpox remain limited. Here, we developed a molecularly imprinted polymer (MIP)-based MPXV sensor targeting A29L, a surface protein involved in host cell binding. The MIP sensor exhibits a remarkable detection limit of 7.7 pg/mL (0.54 pM). Moreover, we demonstrated that the MIP sensor detected A29L in artificial interstitial fluid (AIF) with a detection limit of 12.4 pg/mL (0.86 pM), supporting sensitive detection in a lesion-relevant model matrix. The MIP sensor preferentially responded to A29L over MPXV B6R, vaccinia virus A27L, and biointerferents and retained its response after 30 days. The results indicate that the MIP-based MPXV sensor has strong potential for clinical Mpox detection and could serve as a valuable diagnostic platform in future pandemics.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71847"},"PeriodicalIF":11.0,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Copper Metal-Organic Framework-Embedded Decellularized Matrix Hydrogel Remodels the Uterine Microenvironment for Endometrial Regeneration and Fertility Restoration. 铜金属-有机框架-嵌入脱细胞基质水凝胶重建子宫内膜再生和生育功能恢复的微环境。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-10-18 DOI: 10.1002/adhm.71864

Xingyu Ma, Dongyang Zhao, Jiawei Zhai, Jiaxin Guan, Zihan Yao, Dingming Ye, Xinyi Huang, Hongtao He, Yufan Zhou, Yixiao Li, Tianyu Chen, Meimei Shi, Li Wei, Xiaojun Zhang

{"title":"Copper Metal-Organic Framework-Embedded Decellularized Matrix Hydrogel Remodels the Uterine Microenvironment for Endometrial Regeneration and Fertility Restoration.","authors":"Xingyu Ma, Dongyang Zhao, Jiawei Zhai, Jiaxin Guan, Zihan Yao, Dingming Ye, Xinyi Huang, Hongtao He, Yufan Zhou, Yixiao Li, Tianyu Chen, Meimei Shi, Li Wei, Xiaojun Zhang","doi":"10.1002/adhm.71864","DOIUrl":"https://doi.org/10.1002/adhm.71864","url":null,"abstract":"Severe endometrial injury is a leading cause of female infertility, driven by the convergence of inadequate vascularization, persistent inflammation, infection, and excessive fibrosis. Existing therapies address these pathologies in isolation, falling short of the coordinated remodeling essential for functional regeneration. Here, we report an injectable, thermally responsive composite hydrogel that embeds copper-based metal-organic framework (HKUST-1) nanoparticles within a porcine acellular dermal matrix (PADM) network, coupling biomimetic extracellular matrix support with sustained Cu2 + delivery. In vitro, the hydrogel promotes endothelial migration and tubular network formation, shifts macrophage polarization toward the reparative M2 phenotype, and exhibits broad-spectrum bactericidal activity. In a rat endometrial injury model, it increases gland density and CD31+ neovascularization while suppressing fibrotic collagen deposition. Crucially, it restores hormonal responsiveness by upregulating estrogen and progesterone receptor expression. These coordinated improvements translate into meaningful fertility restoration, with implanted embryos increasing from 8 ± 2 to 14 ± 1. Transcriptomic profiling indicates coordinated changes in extracellular matrix remodeling and ion transport programs. The PADM@HKUST-1 hydrogel demonstrates that integrating biomimetic scaffolding with sustained bioactive ion delivery achieves comprehensive uterine microenvironment remodeling, offering a translatable approach for clinical management of severe endometrial injury.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71864"},"PeriodicalIF":11.0,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep Learning and Engineered Biomaterials-Enhanced Imaging-Guided Cancer Immunotherapy. 深度学习和工程生物材料-增强成像引导的癌症免疫治疗。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-10-18 DOI: 10.1002/adhm.71867

Kaiwei Lv, Bin Li, Bing Xiao, Fei Zhou, Hui Zhao, Jihong Sun, Jun-Long Liang

{"title":"Deep Learning and Engineered Biomaterials-Enhanced Imaging-Guided Cancer Immunotherapy.","authors":"Kaiwei Lv, Bin Li, Bing Xiao, Fei Zhou, Hui Zhao, Jihong Sun, Jun-Long Liang","doi":"10.1002/adhm.71867","DOIUrl":"https://doi.org/10.1002/adhm.71867","url":null,"abstract":"The clinical success of immunotherapies is hindered by the absence of robust methodologies for the early and accurate assessment of antitumor immune responses. Integrating engineered biomaterials with artificial intelligence (AI)-driven molecular imaging technology offers a powerful approach for predicting immune efficacy. However, its clinical translation is significantly hindered by several critical limitations, including the complex and costly synthesis of multifunctional imaging probes, insufficient deep-tissue penetration, suboptimal in vivo signal-to-noise ratios, potential immunogenicity and off-target toxicity, and the limited generalizability of deep learning models across heterogeneous patient populations. In view of these pressing scientific challenges, this review focuses on the application of chemical and biomolecular strategies-enhanced engineered biomaterials in promoting the sensitivity and specificity of advanced imaging modalities for visualizing signaling molecules and immune cells in the tumor microenvironment (TME). Meanwhile, recent progress in deep learning-driven image analysis has enabled strong predictive capabilities and automated the understanding of complex immune system dynamics. Together, these technologies provide a transformative platform for non-invasive monitoring, personalized treatment, and response prediction, with the potential to advance precision immuno-oncology and significantly impact both basic research and clinical translation.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71867"},"PeriodicalIF":11.0,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topically Delivered Treg-Attracting Microparticle-Hydrogel Composites Recruit Regulatory T Cells and Limit Cardiac Injury After Severe Ischemia. 局部递送吸引treg的微粒-水凝胶复合材料招募调节性T细胞并限制严重缺血后的心脏损伤。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-10-18 DOI: 10.1002/adhm.71861

Matthew A Borrelli, Alexis T Reese, Jordan J P Warunek, Betsy Ann Varghese, Canxing Lin, Jeffery J Baust, Brenda McMahon, Steven R Little, Hēth R Turnquist

{"title":"Topically Delivered Treg-Attracting Microparticle-Hydrogel Composites Recruit Regulatory T Cells and Limit Cardiac Injury After Severe Ischemia.","authors":"Matthew A Borrelli, Alexis T Reese, Jordan J P Warunek, Betsy Ann Varghese, Canxing Lin, Jeffery J Baust, Brenda McMahon, Steven R Little, Hēth R Turnquist","doi":"10.1002/adhm.71861","DOIUrl":"https://doi.org/10.1002/adhm.71861","url":null,"abstract":"Ischemic heart disease is a highly prevalent and debilitating condition throughout the world. Following an ischemic injury, the immune response can become overly active and spread damage to nearby healthy tissue. Because the heart lacks regenerative capacity, preventing excessive damage is critical. Existing immunosuppressive therapeutics provide indiscriminate suppression of inflammatory and repair functions of infiltrating immune cells. Regulatory T cells (Treg) are the body's highly sophisticated system for regulating immunologic activity. These cells can provide powerful immune suppression while amplifying repair pathways through direct stimulation of local cells. Our research group has previously developed a polymeric delivery system comprised of poly(lactic-co-glycolic acid) (PLGA) degradable microparticles (MP) loaded with the Treg-attracting protein, CCL22. In our previous work, we demonstrated CCL22MP attracts Treg to the injection site and can suppress disadvantageous inflammation. Here we combine our Treg-attracting MP technology with Hydrogels to Enhance or Attract Regulatory T cells (HEART). Topically applied HEART significantly reduced infarct size and improved ejection fraction after permanent-ligation MI, and in a cardiac transplant ischemia model reduced graft fibrosis while significantly increasing intragraft Foxp3+ Treg at 30 days. Efficacy tracked with injury severity, identifying severe ischemic injury as a setting where this therapeutic strategy may be most beneficial.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71861"},"PeriodicalIF":11.0,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal Programming of Extracellular Vesicles via Nano-Primed SECCS-Based 3D Microenvironments for Coordinated Ferroptosis Suppression and Myogenic Regeneration in Diabetes. 细胞外囊泡的多模态编程，通过纳米启动seccs为基础的三维微环境协调抑制糖尿病的铁凋亡和肌原性再生。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-10-18 DOI: 10.1002/adhm.71868

Zengguang Wang, Hanwen Chang, Yiwei Zhang, Yaokai Gan, Dongyun Gu

{"title":"Multimodal Programming of Extracellular Vesicles via Nano-Primed SECCS-Based 3D Microenvironments for Coordinated Ferroptosis Suppression and Myogenic Regeneration in Diabetes.","authors":"Zengguang Wang, Hanwen Chang, Yiwei Zhang, Yaokai Gan, Dongyun Gu","doi":"10.1002/adhm.71868","DOIUrl":"https://doi.org/10.1002/adhm.71868","url":null,"abstract":"Chronic diabetic glucolipotoxicity is associated with progressive skeletal muscle atrophy, bone loss, cellular senescence, and ferroptotic injury. Because ferroptosis inhibition alone may not restore compromised myogenic capacity, we developed a combined stem cell-conditioning strategy integrating fullerol priming with the stem cell screen-enrich-combine(-biomaterials) circulating system (SECCS). This integrated three-dimensional culture platform uses porous β-TCP granules and intermittent medium circulation to generate BMSCs-derived extracellular vesicles (EVs). Among 2D-EVs, F-2D-EVs, SECCS-EVs, and F-SECCS-EVs, F-SECCS-EVs exhibited the strongest anti-ferroptotic and pro-regenerative effects. In glucolipotoxicity-challenged myoblasts, F-SECCS-EVs attenuated ferroptotic injury and enhanced proliferation and myogenic differentiation. Transcriptomic and functional experiments identified FOXO3 as an important mediator linking antioxidant defense with myogenic programs. In diabetic mice, F-SECCS-EVs improved motor function, muscle strength, myofiber cross-sectional area, and myogenic marker expression while modulating macrophage polarization. Free fullerol, 2D-EVs, and F-2D-EVs produced limited recovery, whereas SECCS-EVs were less effective than F-SECCS-EVs. These muscle benefits were accompanied by favorable changes in tibial bone structure. Collectively, these findings support fullerol-primed SECCS culture as a strategy for coordinating ferroptosis control with myogenic recovery in diabetes-associated musculoskeletal degeneration.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71868"},"PeriodicalIF":11.0,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intelligent Orthopedics: Machine Learning in Diagnosis of Bone Disease, Implants, and Bone Health Monitoring 智能骨科：骨疾病诊断、植入物和骨健康监测中的机器学习。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-10-16 Epub Date: 2026-07-19 DOI: 10.1002/adhm.71447

Maryam Kamaei, Hesam Mohammadi, Shamim Golafshan, Mojtaba Alehosseini, Mahsa Mohammadzadeh, Atefeh Golshirazi, Nasim Golafshan, Tatiane Eufrásio-da-Silva, Alireza Dolatshahi-Pirouz, Gorka Orive

{"title":"Intelligent Orthopedics: Machine Learning in Diagnosis of Bone Disease, Implants, and Bone Health Monitoring","authors":"Maryam Kamaei, Hesam Mohammadi, Shamim Golafshan, Mojtaba Alehosseini, Mahsa Mohammadzadeh, Atefeh Golshirazi, Nasim Golafshan, Tatiane Eufrásio-da-Silva, Alireza Dolatshahi-Pirouz, Gorka Orive","doi":"10.1002/adhm.71447","DOIUrl":"10.1002/adhm.71447","url":null,"abstract":"Bone regeneration in orthopedics is a great challenge, as efficient recovery affects patient's quality of life. Common methods encounter different limitations regarding diagnosis, implantation, and bone health monitoring. Recent advances in artificial intelligence (AI), specifically machine learning (ML) algorithms, have presented opportunities to enhance these aspects by accurately analyzing imaging data. This provides detailed evaluations that help to determine bone condition and guide treatment strategies. ML models can facilitate a patient-specific approach to select and design intelligent implants by examining extensive biomaterial datasets to identify the best match for each patient's biomechanical and biological needs. Furthermore, ML models can analyze data to accurately predict bone-healing timelines, allowing clinicians to track recovery trends, and make timely interventions in potential complications. In clinical settings, ML tools assist with preoperative planning, postoperative follow-up, and the design of intelligent implants, offering more effective, data-driven decision-making and favorable outcomes in bone regeneration. Looking ahead, while ML advancements show promise for effective orthopedic therapies, challenges persist. ML could revolutionize bone regeneration in various ways and offer predictive insights that promote patient-centered orthopedic care. Altogether, considering the continued evolution of ML, its integration into clinical applications will be crucial for developing truly intelligent bone regeneration therapies.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 38","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.71447","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148519625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Hybrid Bioprinting–Microfabrication Approach to Controllable Multitype Spheroid Arrays for Modeling Tumor Heterogeneity 基于生物打印-微加工的可控多型球体阵列肿瘤异质性建模方法。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-10-16 Epub Date: 2026-09-20 DOI: 10.1002/adhm.71725

Simone Bonetti, Eva Clemente, Emanuela Mensà, Marco de Maria, Fulvia Farabegoli, Emanuela Saracino, Barbara Bortolani, Emanuela Marcelli, Renato Brandimarti, Dario de Biase, Giampaolo Zuccheri

{"title":"A Hybrid Bioprinting–Microfabrication Approach to Controllable Multitype Spheroid Arrays for Modeling Tumor Heterogeneity","authors":"Simone Bonetti, Eva Clemente, Emanuela Mensà, Marco de Maria, Fulvia Farabegoli, Emanuela Saracino, Barbara Bortolani, Emanuela Marcelli, Renato Brandimarti, Dario de Biase, Giampaolo Zuccheri","doi":"10.1002/adhm.71725","DOIUrl":"10.1002/adhm.71725","url":null,"abstract":"The intrinsic heterogeneity of solid tumors remains a crucial barrier to understanding cancer biology and predicting therapeutic outcomes. Here, we introduce a scalable and versatile biofabrication platform that enables the controlled assembly of multitype spheroid arrays (MSA) within standard culture microplates. By performing programmable bioprinting within soft, microstructured culture devices, we achieve the precise spatial deposition of multiple cell types into defined microwells, yielding reproducible arrays of heterogeneous 3D tumor spheroids that collectively recapitulate the macro- and micro-heterogeneity of solid cancers. We demonstrate that this approach permits the fine-tuning of spheroid size, composition, and arrangement. It also supports the delayed secondary programmed seeding of cells on pre-grown spheroids, mimicking biological processes such as the invasion of immune cells. These methods enable quantitative drug-response profiling within a single assay. They overcome some critical limitations of current 3D cancer models, introducing the concept of the “cancer-in-a-well” technology. This technology provides a simple-to-use, cost-effective, high-throughput, and highly reproducible platform to recreate the complexity of tumors in vitro using methods and instruments that can be potentially used by any researcher in any cell culture lab. We can foresee a positive impact on cancer biology studies, drug screening, and personalized oncology.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 38","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.71725","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intelligent Orthopedics: Machine Learning in Diagnosis of Bone Disease, Implants, and Bone Health Monitoring (Adv. Healthcare Mater. 38/2026) 智能骨科：机器学习在骨病诊断、植入物和骨健康监测中的应用（Adv. Healthcare Mater. 38/2026）

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-10-16 DOI: 10.1002/adhm.71675

Maryam Kamaei, Hesam Mohammadi, Shamim Golafshan, Mojtaba Alehosseini, Mahsa Mohammadzadeh, Atefeh Golshirazi, Nasim Golafshan, Tatiane Eufrásio-da-Silva, Alireza Dolatshahi-Pirouz, Gorka Orive

引用次数: 0

A Self-Assembling Janus Dendron-Modified Phthalocyanine Enables Deep Tumor-Targeted Therapy for Gastric Cancer Peritoneal Metastases 自组装Janus树突修饰的酞菁使胃癌腹膜转移的深部肿瘤靶向治疗成为可能。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-10-16 Epub Date: 2026-09-07 DOI: 10.1002/adhm.71702

Jianping Guo, Shujie Zhang, Zijian Deng, Guantao He, Yiming Guo, Longyang Jin, Di Zhang, Keqian Du, Zhizhong Xiong, Shi Yin, Saddam Ahmed Mohamed, Lin-Ping Wu, Lei Lian

{"title":"A Self-Assembling Janus Dendron-Modified Phthalocyanine Enables Deep Tumor-Targeted Therapy for Gastric Cancer Peritoneal Metastases","authors":"Jianping Guo, Shujie Zhang, Zijian Deng, Guantao He, Yiming Guo, Longyang Jin, Di Zhang, Keqian Du, Zhizhong Xiong, Shi Yin, Saddam Ahmed Mohamed, Lin-Ping Wu, Lei Lian","doi":"10.1002/adhm.71702","DOIUrl":"10.1002/adhm.71702","url":null,"abstract":"<div>\u0000 \u0000 Peritoneal metastasis is a leading cause of mortality in end-stage gastric cancer and remains poorly responsive to conventional chemotherapy. To address this unmet need, Janus dendron-modified phthalocyanines were developed as tumor-targeted photosensitizers for photodynamic therapy (PDT). A series of Janus dendron-modified phthalocyanines with tailored surface functionalities s synthesized, exhibiting spontaneous self-assembly into nanoparticles with augmented fluorescence, amplified reactive oxygen species (ROS) production, and improved tumor-targeting specificity. Among them, the lead compound TT1-4PYR, bearing pyrrolidone moieties, demonstrated ascites-derived protein corona and macropinocytosis-mediated cellular internalization, enabling deep penetration and selective accumulation in peritoneal metastasis lesions. Comprehensive evaluation in vitro, in vivo, and in human-derived gastric cancer organoid models confirmed its potent and targeted photodynamic cytotoxicity, effectively suppressing tumor progression without inducing systemic toxicity, achieving a favorable biosafety profile. These results highlight TT1-4PYR as a promising and deep-penetrating therapeutic agent for peritoneal metastasis, with potential applicability to other metastatic malignancies.\u0000 </div>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 38","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0