Advanced Healthcare Materials最新文献

NIR-Propelled Thermosensitive Bowl-Shaped Nanomotors with High Penetration and Targeting for Photoacoustic Imaging Guided Thrombolysis Therapy.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-03-24 DOI: 10.1002/adhm.202404960

Yina Su, Linjie Huang, Guizhen Xu, Simin Chen, Jiaqiong Wu, Siyu Wang, Yichao Zhang, Xiahui Lin

{"title":"NIR-Propelled Thermosensitive Bowl-Shaped Nanomotors with High Penetration and Targeting for Photoacoustic Imaging Guided Thrombolysis Therapy.","authors":"Yina Su, Linjie Huang, Guizhen Xu, Simin Chen, Jiaqiong Wu, Siyu Wang, Yichao Zhang, Xiahui Lin","doi":"10.1002/adhm.202404960","DOIUrl":"https://doi.org/10.1002/adhm.202404960","url":null,"abstract":"Traditional antithrombotic therapeutic strategies encounter challenges including heightened bleeding risks, short circulation times, low targeting ability, and inferior thrombus penetration. Therefore, a novel thrombolysis nanodrug (APBUL) is designed that incorporates urokinase (UK) loaded onto the surface of bowl-shaped nanomotors (APBs) encapsulated within fibrin peptide (CREKA)-modified thermosensitive liposomes, presenting an innovative therapeutic platform for thrombolysis. APBUL leverages CREKA's targeting ability for thrombus accumulation. Subsequently, under the irradiation of near-infrared light, the thermosensitive liposomal shell undergoes controlled disruption, releasing internal APBs and UK. Then, the APBs move directionally though thermophoresis effect, facilitating photothermal therapy and deep thrombus penetration, and synergistically enhancing UK release and diffusion to optimize thrombolysis. Moreover, the APBUL possesses a catalase-like activity, catalyzing hydrogen peroxide into oxygen to alleviate oxidative stress and inflammatory factors at the thrombus site, thereby lowering the recurrence risk. Combined with the ability of APBUL's photoacoustic imaging, this new strategy is expected to provide an inspiring idea for the integrated use of clinical thrombolytic therapy in diagnosis, imaging, and treatment.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2404960"},"PeriodicalIF":10.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protein-Interference-Free and Kidney-Targeting NIR Fluorophores for Accurate in Vivo Imaging of H₂S₂ during Kidney Ferroptosis.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-03-24 DOI: 10.1002/adhm.202500273

Zhangkang Lv, Jing Wang, Jinyuan Xu, Xiaoshan Chen, Dongxue Lu, Jingting Huang, Xing-Can Shen, Hua Chen

{"title":"Protein-Interference-Free and Kidney-Targeting NIR Fluorophores for Accurate in Vivo Imaging of H2S2 during Kidney Ferroptosis.","authors":"Zhangkang Lv, Jing Wang, Jinyuan Xu, Xiaoshan Chen, Dongxue Lu, Jingting Huang, Xing-Can Shen, Hua Chen","doi":"10.1002/adhm.202500273","DOIUrl":"https://doi.org/10.1002/adhm.202500273","url":null,"abstract":"High-fidelity kidney function imaging is important for assessing the nephrotoxicity of drugs and diagnosing renal diseases. However, the current challenges in achieving accurate kidney imaging include unspecific signal enhancement due to albumin binding and relatively low distribution of imaging agents in kidneys. Here, for the first time, a side-chain engineering strategy that incorporates hydrophilic six-membered heterocycles into aza-hemicyanine for generating high-performance kidney imaging agents with protein-interference-free and kidney-targeting features is proposed. Based on these unique aza-hemicyanine dyes, the first kidney-targeting and albumin-insensitive H2S2 near-infrared (NIR) fluorescent probe NA-H2S2 is designed, which demonstrates effective kidney distribution following intravenous injection and is specifically activated by H2S2. The designed probe presents a highly rapid, selective and sensitive response to H2S2 with a detection limit as low as 24.21 nm. Additionally, it successfully achieves real-time in vivo NIR fluorescence imaging of H2S2 during erastin/cisplatin induced renal ferroptosis. Moreover, it also enables rapid detection of H2S2 through in vitro optical urinalysis, offering significant diagnostic value for renal ferroptosis. Overall, this study not only presents a practical kidney-targeting H2S2 fluorescent probe NA-H2S2 with increased imaging accuracy but also provides promising kidney-targeting and albumin-insensitive aza-hemicyanine dyes for further development of kidney disease-related probes.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2500273"},"PeriodicalIF":10.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unlocking the Untapped Potential of Photoresponsive Dual-Gas Nanomedicine in Glaucoma Therapy.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-03-24 DOI: 10.1002/adhm.202404245

Jiamin Liu, Yuan Liang, Yi Tian, Xinghuai Sun, Yuan Lei, Pengpeng Lei, Hongjie Zhang

{"title":"Unlocking the Untapped Potential of Photoresponsive Dual-Gas Nanomedicine in Glaucoma Therapy.","authors":"Jiamin Liu, Yuan Liang, Yi Tian, Xinghuai Sun, Yuan Lei, Pengpeng Lei, Hongjie Zhang","doi":"10.1002/adhm.202404245","DOIUrl":"https://doi.org/10.1002/adhm.202404245","url":null,"abstract":"Glaucoma, a leading cause of irreversible blindness worldwide, is characterized by optic nerve damage often associated with elevated intraocular pressure (IOP). Although gas therapies hold promise for glaucoma treatment, the limitations of single-gas strategies constrain their therapeutic efficacy. Here, a photoresponsive dual-gas nanomedicine is developed for targeted glaucoma therapy. The nanomedicine, PdH-D-S, is engineered by synthesizing mesoporous palladium hydride (meso-PdH) with efficient hydrogen (H₂) storage capacity and abundant pore channels, followed by surface modification with DSPE-mPEG and loading sodium nitroprusside (SNP) as a nitric oxide (NO) donor. PdH-D-S penetrates the cornea to reach IOP-regulating tissues, including the trabecular meshwork and Schlemm's canal. Upon 808 nm laser excitation, PdH-D-S releases H₂ and NO in a controlled manner. H₂ activates the AKT/p-AKT/eNOS/sGC signaling pathway, while NO binds to soluble guanylate cyclase (sGC), converting guanosine triphosphate (GTP) to cyclic guanosine monophosphate (cGMP), relaxing trabecular meshwork cells and enhancing aqueous humor outflow. This dual-gas system demonstrates high therapeutic efficacy in lowering IOP and offers a mechanistic advancement in glaucoma treatment through synergistic gas therapy.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2404245"},"PeriodicalIF":10.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human Myobundle Platform for Studying the Role of Notch Signaling in Satellite Cell Phenotype and Function.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-03-24 DOI: 10.1002/adhm.202404695

Torie Broer, Nick Tsintolas, Stewart Hammond, Abbigail Helfer, Joonbum Lee, Karly Purkey, Sophia DeLuca, Alastair Khodabukus, Nenad Bursac

{"title":"Human Myobundle Platform for Studying the Role of Notch Signaling in Satellite Cell Phenotype and Function.","authors":"Torie Broer, Nick Tsintolas, Stewart Hammond, Abbigail Helfer, Joonbum Lee, Karly Purkey, Sophia DeLuca, Alastair Khodabukus, Nenad Bursac","doi":"10.1002/adhm.202404695","DOIUrl":"https://doi.org/10.1002/adhm.202404695","url":null,"abstract":"Notch signaling plays a pivotal role in regulating satellite cell (SC) behavior during skeletal muscle development, homeostasis, and repair. While well-characterized in mouse models, the impact of Notch signaling in human muscle tissues remains largely underexplored. Here, a 3D tissue-engineered model of human skeletal muscle (\"myobundles\") is utilized as an in vitro platform for temporal control and studies of Notch singaling. Myofiber-specific overexpression of the Notch ligand, DLL1, early in myobundle differentiation increases the abundance of 3D SCs and shifts their phenotype to a more quiescent-like state, along with decreasing muscle mass and function. In contrast, myofiber-specific DLL1 overexpression after one week of myobundle differentiation does not affect 3D SC abundance or muscle function, but increases transcriptomic markers of SC quiescence, confirming the temporal dependence of SC activation and self-renewal on Notch signaling activity. Finally, for the first time these studies show that even after a transient, myofiber-specific upregulation of Notch signaling in myobundles, 3D SCs expanded from these tissues can re-form functional \"secondary\" myobundles containing an amplified SC pool. Future studies in the described human myobundle platform are expected to aid the development of novel Notch-targeted therapies for muscular dystrophies and aging.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2404695"},"PeriodicalIF":10.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Soft Pneumatic Device Designed to Mimic the Periosteal Environment for Regulating the Fate of Mesenchymal Stem Cells.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-03-24 DOI: 10.1002/adhm.202403229

Gwang-Bum Im, Jae Gyeong Lee, Hosub Lim, Jae-Won Lee, Hyun Su Park, Yongju Kim, Nauman Asad, Hak-Rin Kim, Jeong Jae Wie, Suk Ho Bhang

{"title":"Soft Pneumatic Device Designed to Mimic the Periosteal Environment for Regulating the Fate of Mesenchymal Stem Cells.","authors":"Gwang-Bum Im, Jae Gyeong Lee, Hosub Lim, Jae-Won Lee, Hyun Su Park, Yongju Kim, Nauman Asad, Hak-Rin Kim, Jeong Jae Wie, Suk Ho Bhang","doi":"10.1002/adhm.202403229","DOIUrl":"https://doi.org/10.1002/adhm.202403229","url":null,"abstract":"Replicating the complex mechanical forces of muscle movement and fluid flow in in vitro cell culture systems is crucial for understanding cell differentiation and development. However, previous research focused on cell differentiation on static micro/nanotextures without a force field or flat 2-dimensional substrates under a continuous in-plane mechanical force. In this study, cell differentiation is reported using a spatial geometric platform that can periodically modulate complex mechanical forces through a custom-made soft pneumatic device (SPD) to mimic the interfaces between periosteum and interstitial fluid. To elucidate fluidic dynamics and cell fates relevant to bone physiology, the platform exhibited distinct functional responses based on mechanical force levels: low mechanotransduction induced mesenchymal stem/progenitor cells differentiation into osteoprogenitor cells (≈1.5-fold increase in osteo-differentiation), while high mechanotransduction resulted in structural disruptions resembling cell detachment without protein degradation (≈2-fold increase in effective cell detachment). Numerical simulations of SPD elucidated the principal mechanical components for programmable cell differentiation and detachment by deconvoluting the in-plane and out-of-plane mechanical forces of the SPD complex mode. This study offers comprehensive and novel insights into the correlation between mechanical forces and cell differentiation, recovery, and injury in organisms.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403229"},"PeriodicalIF":10.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Porous Fe/Cu Nanoreactor with Dual Insurance Design for Precision Chemotherapy and Chemodynamic Therapy.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-03-24 DOI: 10.1002/adhm.202405229

Xianyu Zhu, Lingli Gao, Yanbo Zheng, Peng Fei Zhao, Hanrui Wei, Ruixue Liu, Liping Zhao, Junyi Zhang, Qi Sun, Lingling Zheng, Han Lv, JiGang Yang, Jianhua Gong, Zhenchang Wang

{"title":"Porous Fe/Cu Nanoreactor with Dual Insurance Design for Precision Chemotherapy and Chemodynamic Therapy.","authors":"Xianyu Zhu, Lingli Gao, Yanbo Zheng, Peng Fei Zhao, Hanrui Wei, Ruixue Liu, Liping Zhao, Junyi Zhang, Qi Sun, Lingling Zheng, Han Lv, JiGang Yang, Jianhua Gong, Zhenchang Wang","doi":"10.1002/adhm.202405229","DOIUrl":"https://doi.org/10.1002/adhm.202405229","url":null,"abstract":"Poor prognosis and chemotherapy response stem from difficulties in precise targeting and the lack of effective synergistic treatments. Nanozymes show promising potential in tumor chemodynamic therapy (CDT) by catalyzing hydrogen peroxide (H₂O₂) decomposition and glutathione depletion in the tumor microenvironment (TME). However, integrating precise chemotherapy targeting with CDT remains challenging. In this study, a porous Fe/Cu bimetallic nanozyme carrier (FeCuNPs) is developed for co-loading with the humanized 3F8 anti-GD2 disialoganglioside antibody (3F8) and the novel pyridazinone-based chemotherapeutic agent (IMB), forming a nanoreactor (3F8@FeCuNPs@IMB) for targeted chemotherapy and CDT. The nanoreactor responds specifically to the acidic TME as a primary insurance, allowing for the controlled release of IMB at the tumor site. The targeting antibody 3F8 coating on the surface of the nanozyme carrier acts as a secondary insurance, minimizing chemotherapy drug leakage during the delivery process and ensuring precise targeting for effective chemotherapy. Furthermore, FeCuNPs act as peroxidase-like (POD) and glutathione oxidase-like (GSHOX) enzymes, catalyzing hydroxyl radical (•OH) generation and depleting excess GSH, enhancing CDT. The results in vitro and in vivo indicate that the dual insurance designed 3F8@FeCuNPs@IMB offers a promising prospect for a targeted, precise, and effective combination of chemotherapy and CDT against melanoma.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2405229"},"PeriodicalIF":10.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prodigiosin Loaded SN-PB@PG NPs-Based Multimodal Therapy for the Healing of Bacterial Infected Chronic Wounds.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-03-23 DOI: 10.1002/adhm.202405100

Zhou Wu, Li Chang, Changling Li, Pengxiang Xu, Liuying Liu, Aidi Tong, Yilong Li, Chunyi Tong, Bin Liu

{"title":"Prodigiosin Loaded SN-PB@PG NPs-Based Multimodal Therapy for the Healing of Bacterial Infected Chronic Wounds.","authors":"Zhou Wu, Li Chang, Changling Li, Pengxiang Xu, Liuying Liu, Aidi Tong, Yilong Li, Chunyi Tong, Bin Liu","doi":"10.1002/adhm.202405100","DOIUrl":"https://doi.org/10.1002/adhm.202405100","url":null,"abstract":"Healing of infected chronic wounds faces dual challenges: persistent inflammation and impaired angiogenesis. To address these, SN-PB@PG nanocomplexes were prepared by hybridisation of nitroprusside (SNP) with Prussian blue (SN-PB NPs) and loaded with prodigiosin (PG). Under near-infrared (NIR) irradiation, SN-PB NPs generated mild hyperthermia, facilitating the release of nitric oxide (NO) and PG to combat bacterial biofilms and multidrug-resistant pathogens. The in vivo assay using diabetic infected wounds demonstrated that SN-PB@PG NPs with NIR reduced the wound area to 10.6% by the 11th day, which is superior to that of control group (29.6%). In the flap transplantation experiments, the data showed SN-PB@PG NPs with NIR group only have a necrobiosis of 3.8% of flaps on the 8th day, which is superior to 31.3% of the control group. Additionally, the release of NO promoted vascular regeneration by up-regulating vascular endothelial growth factor (VEGF) and platelet endothelial cell adhesion molecule-1 (CD31), and regenerated sarcomeric tissue by down-regulating MMP-9. The results indicated that the combination of SN-PB@PG NPs with gas and photothermal therapy exerted a combined antibacterial and wound healing effect. Compared to traditional clinical methods such as surgical debridement and hyperbaric oxygen therapy, this new strategy efficiently addresses issues of infection and healing, which is convenient for clinical application.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2405100"},"PeriodicalIF":10.0,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nano-Topography Enhanced Topological-Cell-Analysis in Radiation-Therapy.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-03-22 DOI: 10.1002/adhm.202405187

Francesca Pagliari, Maria-Francesca Spadea, Pierre Montay-Gruel, Anggraeini Puspitasari-Kokko, Joao Seco, Luca Tirinato, Angelo Accardo, Francesco De Angelis, Francesco Gentile

{"title":"Nano-Topography Enhanced Topological-Cell-Analysis in Radiation-Therapy.","authors":"Francesca Pagliari, Maria-Francesca Spadea, Pierre Montay-Gruel, Anggraeini Puspitasari-Kokko, Joao Seco, Luca Tirinato, Angelo Accardo, Francesco De Angelis, Francesco Gentile","doi":"10.1002/adhm.202405187","DOIUrl":"https://doi.org/10.1002/adhm.202405187","url":null,"abstract":"Radiotherapy (RT) is a cancer treatment technique that involves exposing cells to ionizing radiation, including X-rays, electrons, or protons. RT offers promise to treat cancer, however, some inherent limitations can hamper its performance. Radio-resistance, whether innate or acquired, refers to the ability of tumor cells to withstand treatment, making it a key factor in RT failure. This perspective hypothesizes that nanoscale surface topography can impact on the topology of cancer cells network under radiation, and that this understanding can possibly advance the assessment of cell radio-resistance in RT applications. An experimental plan is proposed to test this hypothesis, using cancer cells exposed to various RT forms. By examining the influence of 2D surface and 3D scaffold nanoscale architecture on cancer cells, this approach diverges from traditional methodologies, such as clonogenic assays, offering a novel viewpoint that integrates fields such as tissue engineering, artificial intelligence, and nanotechnology. The hypotheses at the base of this perspective not only may advance cancer treatment but also offers insights into the broader field of structural biology. Nanotechnology and label-free Raman phenotyping of biological samples are lenses through which scientists can possibly better elucidate the structure-function relationship in biological systems.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2405187"},"PeriodicalIF":10.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metal-Organic Frameworks for the Therapy of Inflammatory Diseases.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-03-21 DOI: 10.1002/adhm.202404334

Heng Zhao, Christian Serre, Nathalie Steunou

{"title":"Metal-Organic Frameworks for the Therapy of Inflammatory Diseases.","authors":"Heng Zhao, Christian Serre, Nathalie Steunou","doi":"10.1002/adhm.202404334","DOIUrl":"https://doi.org/10.1002/adhm.202404334","url":null,"abstract":"Inflammation is a natural immune response triggered by harmful external or internal stimuli. However, when inflammation fails to resolve and restore basal homeostasis, it can lead to various inflammatory diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and diabetic chronic wound (DCW). The modulation of inflammation follows a highly complex mechanism, and monotherapy is often insufficient for treating such conditions. Therefore, developing next-generation nanocarriers for anti-inflammatory drug delivery and multi-target combination therapies is critical. Metal-organic frameworks (MOFs), a class of porous coordination polymers with large surface areas and adaptable porosity, have emerged as promising drug delivery systems (DDS) due to their biodegradability, high drug loading capacity, stimuli-responsive drug release, and ease of functionalization. Over the past five years, MOFs have shown significant promise in treating inflammatory diseases, either as DDS or as intrinsic anti-inflammatory and anti-oxidative agents. Additionally, hybrid MOFs, which combine MOFs with nanozymes, offer a multifunctional anti-inflammatory platform with great potential. This review intends to provide a comprehensive review of the recent development of MOF-based nanomedicines for the therapy of inflammatory diseases. The challenges and future directions of research into the use of MOFs in the treatment of these diseases will also be discussed.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2404334"},"PeriodicalIF":10.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143672975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Progress on Antibacterial Applications of Bioactive Materials in Wound Infections: Design, Challenges, and Prospects. 生物活性材料在伤口感染中的抗菌应用研究进展：设计、挑战与前景》。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-03-21 DOI: 10.1002/adhm.202405103

Wang Zheng, Yuanfang Cheng, Hui Shen, Litao Liu, Wei Hu, Haisheng Qian

引用次数: 0