Advanced Healthcare Materials最新文献

A Microenvironment-Responsive Graphdiyne-Iron Nanozyme Hydrogel with Antibacterial and Anti-Inflammatory Effect for Periodontitis Treatment.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-20 DOI: 10.1002/adhm.202403683

Xiaojie Wu, Lu Wang, Yaning Lu, Meng-Hao Li, Shuwei Liu, Yimeng Yang, Yulian Song, Sunzhuo Chen, Jing Kang, Alideertu Dong, Ying-Wei Yang

{"title":"A Microenvironment-Responsive Graphdiyne-Iron Nanozyme Hydrogel with Antibacterial and Anti-Inflammatory Effect for Periodontitis Treatment.","authors":"Xiaojie Wu, Lu Wang, Yaning Lu, Meng-Hao Li, Shuwei Liu, Yimeng Yang, Yulian Song, Sunzhuo Chen, Jing Kang, Alideertu Dong, Ying-Wei Yang","doi":"10.1002/adhm.202403683","DOIUrl":"https://doi.org/10.1002/adhm.202403683","url":null,"abstract":"Periodontitis is a chronic inflammatory disease caused by dental plaque, which leads to tooth loosening and shifting or even tooth loss. Current treatments, including mechanical debridement and antibiotics, often fail to eradicate recalcitrant biofilms and mitigate excessive inflammation. Moreover, these interventions can disrupt the oral microbiome, potentially compromising long-term treatment outcomes. To address these limitations, an injectable nanoenzyme hydrogel composed of a dopamine (DA)-modified hyaluronic acid (HA) scaffold and a graphdiyne-iron (GDY-Fe) complex, named GDY-Fe@HA-DA, exhibits excellent tissue adhesion, self-healing, antibacterial properties, and biocompatibility. Under near-infrared laser irradiation, GDY-Fe@HA-DA effectively eradicates a variety of pathogens, including Escherichia coli, Staphylococcus aureus, and Porphyromonas gingivalis, through a synergistic combination of chemodynamical and photothermal therapies. The hydrogel's efficacy is further validated in both bacterial-infected skin wounds and rat periodontitis models. It effectively alleviates the inflammatory environment and promotes wound healing and periodontal tissue recovery. This findings highlight the potential of GDY-Fe@HA-DA as a promising therapeutic material for periodontitis and other tissue injuries.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403683"},"PeriodicalIF":10.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ginsenoside Rd-Loaded Antioxidant Polymersomes to Regulate Mitochondrial Homeostasis for Bone Defect Healing in Periodontitis.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-20 DOI: 10.1002/adhm.202403817

Congjiao Hu, Junqiu Shi, Fan Zhang, Mingchen Lv, Zhenghong Ge, Meiting Feng, Zhen Fan, Danqing Liu, Jianzhong Du, Yao Sun

{"title":"Ginsenoside Rd-Loaded Antioxidant Polymersomes to Regulate Mitochondrial Homeostasis for Bone Defect Healing in Periodontitis.","authors":"Congjiao Hu, Junqiu Shi, Fan Zhang, Mingchen Lv, Zhenghong Ge, Meiting Feng, Zhen Fan, Danqing Liu, Jianzhong Du, Yao Sun","doi":"10.1002/adhm.202403817","DOIUrl":"https://doi.org/10.1002/adhm.202403817","url":null,"abstract":"Periodontitis is the leading cause of tooth loss in adults. Initially triggered by bacterial infection, it is characterized by subsequent dysregulation of mitochondrial homeostasis, leading to ongoing loss of periodontal tissue. Mitophagic flux, a critical physiological mechanism for maintaining mitochondrial homeostasis, is compromised in periodontitis. Additionally, increased release of reactive oxygen species (ROS) exacerbates mitochondrial damage. In this study, a ginsenoside Rd (Rd)-loaded antioxidative polymersome (RdAP) is designed, which is self-assembled from a mitochondrial-protective and ROS-scavenging block copolymer, poly(ethylene oxide)-block-poly(phenylboronic acid pinacol ester-conjugated polylysine) (PEO113-b-P(Lys-PAPE)60). The phenylboronic acid pinacol ester (PAPE) segment exhibits excellent ROS-responsive properties, enabling effective ROS scavenging through antioxidant production. Rd significantly enhances mitophagic flux by 2.5-fold in periodontal ligament stem cells (PDLSCs) under oxidative stress. Together with the antioxidative polymersome, RdAPs restore mitochondrial homeostasis and enhance the osteogenic capacity of PDLSCs, bringing it closer to that of healthy controls. In a mouse model of periodontitis, the bone mass in the RdAP-treated group is 1.37 times greater than that in the untreated periodontitis group. Overall, the findings propose a novel strategy for addressing refractory periodontitis, which may also be applicable to other diseases characterized by mitochondrial homeostasis imbalance.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403817"},"PeriodicalIF":10.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RETRACTION: Drug "Pent-Up" in Hollow Magnetic Prussian Blue Nanoparticles for NIR-Induced Chemo-Photothermal Tumor Therapy with Trimodal Imaging.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-20 DOI: 10.1002/adhm.202404868

引用次数: 0

Effective Hydrogel Vascular Patch Dual-Loaded with Cycloastragenol Nanostructured Lipid Carriers and Doxycycline for Repairing Extravascular Injury in Abdominal Aortic Aneurysm.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-20 DOI: 10.1002/adhm.202402497

Du Chen, Tiantian Song, Yi Liu, Ying Wang, Boyang Qin, Qingyi Zhang, Weipeng Hu, Xiqiao Zhou, Rong Qi

{"title":"Effective Hydrogel Vascular Patch Dual-Loaded with Cycloastragenol Nanostructured Lipid Carriers and Doxycycline for Repairing Extravascular Injury in Abdominal Aortic Aneurysm.","authors":"Du Chen, Tiantian Song, Yi Liu, Ying Wang, Boyang Qin, Qingyi Zhang, Weipeng Hu, Xiqiao Zhou, Rong Qi","doi":"10.1002/adhm.202402497","DOIUrl":"https://doi.org/10.1002/adhm.202402497","url":null,"abstract":"Endovascular aneurysm repair (EVAR) plays a crucial role in the treatment of abdominal aortic aneurysm (AAA) in the clinic, but the aneurysm remains in the patient's body after surgery, continuing to pose a risk of progression. Cycloastragenol (CAG) is proven to be an effective anti-AAA drug, and its vascular protective effects can be further improved when the hydrophobic CAG is encapsulated into nano-sized formulations to enhance its bioavailability. In this context, this study developed an extravascular patch hydrogel loaded with CAG nanostructured lipid carriers and a hydrophilic drug of doxycycline hydrochloride (DOX). The extravascular patch delivered onto the mouse abdominal aortas can promote local permeation of hydrophilic/hydrophobic drugs at the vessel sites and provide effective vascular protection against AAA injury induced by elastase. This study introduces a novel and promising approach for AAA treatment, which can serve as a supplementary strategy after EVAR surgery.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2402497"},"PeriodicalIF":10.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Remodeling the Inflammatory and Immunosuppressive Tumor Microenvironment for Enhancing Antiangiogenic Gene Therapy of Colorectal Cancer.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-19 DOI: 10.1002/adhm.202402887

Niu Jiazhen, Su Meihui, Liu De-E, Li Na, Xin Youtao, Chen Qixian, Yu Yunjian, Ma Feihe, Elsabahy Mahmoud, Gao Hui

{"title":"Remodeling the Inflammatory and Immunosuppressive Tumor Microenvironment for Enhancing Antiangiogenic Gene Therapy of Colorectal Cancer.","authors":"Niu Jiazhen, Su Meihui, Liu De-E, Li Na, Xin Youtao, Chen Qixian, Yu Yunjian, Ma Feihe, Elsabahy Mahmoud, Gao Hui","doi":"10.1002/adhm.202402887","DOIUrl":"https://doi.org/10.1002/adhm.202402887","url":null,"abstract":"Fusobacterium nucleatum (Fn), as an intestinal pathogenic bacterium, is closely related to the occurrence, progression, and limited therapeutic efficacy of colorectal cancer (CRC). The presence of Fn within CRC communities induces an inflammatory and immunosuppressive microenvironment while promoting new vessel formation. Therefore, developing novel methods to efficiently eliminate Fn and enhance the therapeutic outcomes against Fn-associated CRC is of great significance. Herein, a nanosystem named AFGTs-PEG, which integrates antimicrobial agent lauric acid (LA), an antiangiogenic gene (sFlt-1), a targeted polymer (OEI-LA/PBA, OLP), and DSPE-mPEG, to boost the gene therapy of Fn-infected CRC, is developed. The sFlt-1 gene is delivered to CRC cells through lysosome escape, remarkably inhibiting new vessel formation at the CRC site and ultimately leading to CRC cell death. In principle, LA is used to eliminate Fn and its biofilms, and remodel the inflammatory and immunosuppressive microenvironment by restraining the generation of inflammatory factors and preventing polarization of M1 into M2 macrophages, thereby mitigating the adverse effects of Fn on antiangiogenic gene therapy. This study holds great promise for the treatment of bacteria-colonized tumors.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2402887"},"PeriodicalIF":10.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Controllable Self-Assembly of V═O Metalloradical Complex with Intramolecular Charge Transfer for Enhanced NIR-II Fluorescence Imaging-Guided Photothermal Therapy.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-18 DOI: 10.1002/adhm.202404262

Jianshuai Bao, Zengyin Li, Deliang Wang, Jiefei Wang, Guan Huang, Jianlei Qian, Xiaoyan Yang, Peng-Cheng Duan, Sheng Zhang, Feng Bai, Yong Zhong

{"title":"Controllable Self-Assembly of V═O Metalloradical Complex with Intramolecular Charge Transfer for Enhanced NIR-II Fluorescence Imaging-Guided Photothermal Therapy.","authors":"Jianshuai Bao, Zengyin Li, Deliang Wang, Jiefei Wang, Guan Huang, Jianlei Qian, Xiaoyan Yang, Peng-Cheng Duan, Sheng Zhang, Feng Bai, Yong Zhong","doi":"10.1002/adhm.202404262","DOIUrl":"https://doi.org/10.1002/adhm.202404262","url":null,"abstract":"Near-infrared second region (NIR-II) fluorescence imaging provides enhanced tissue penetration, achieving efficient NIR-II fluorescence and photoacoustic imaging (PA)-guided photothermal therapy (PTT) all in one material remains a challenging yet promising approach in cancer treatment. Herein, open-shell V═O metalloradical complex (VONc) is self-assembled into VONc nanospheres (VONc NPs). VONc NPs exhibit light absorption from 300 to 1400 nm, fluorescence spectra ranging from 900 to 1400 nm, and a distinct fluorescence signal even at 1550 nm. Moreover, VONc NPs exhibit outstanding photostability and a higher photothermal conversion efficiency of 46.6% than that of closed-shell zinc naphthalocyanine nanorods (ZnNc NRs). V═O centered metalloradical serves as transient electron-withdrawing groups to facilitate charge transfer (CT), introducing additional nonradiative energy dissipation pathways and enhancing efficient heat generation. In vitro experiments of VONc NPs indicate that a highly effective photothermal action causes harm to both mitochondria and lysosomes, resulting in the death of tumor cells, closed-shell ZnNc NPs exhibit almost no cell killing as contrast. In vivo anti-tumor therapy results of VONc NPs demonstrate excellent NIR-II fluorescence imaging-guided PTT against tumors with a favorable biosafety profile. \"Centered metalloradical boosting CT\" toward open-shell metal complexes provides significant insight for developing single-material integrated nanosystems for diagnostic and therapeutic applications.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2404262"},"PeriodicalIF":10.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LOX-1-Based Assembly Layer on Devices Surface to Promote Endothelial Repair and Reduce Complications for In Situ Interventional Plaque. 基于 LOX-1 的设备表面组装层可促进内皮修复并减少原位介入斑块的并发症。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-18 DOI: 10.1002/adhm.202403060

Sainan Liu, Jinquan Huang, Jiayan Luo, Xiaowa Gao, Siqi Song, Qihao Bian, Yajun Weng, Junying Chen

{"title":"LOX-1-Based Assembly Layer on Devices Surface to Promote Endothelial Repair and Reduce Complications for In Situ Interventional Plaque.","authors":"Sainan Liu, Jinquan Huang, Jiayan Luo, Xiaowa Gao, Siqi Song, Qihao Bian, Yajun Weng, Junying Chen","doi":"10.1002/adhm.202403060","DOIUrl":"https://doi.org/10.1002/adhm.202403060","url":null,"abstract":"Rapid endothelialization and functional recovery are considered as promising methods to extend the long-term effectiveness of cardiovascular implant materials. LOX-1 participates in the initiation and development of atherosclerosis and is highly expressed in a variety of cells involved in atherosclerosis, hence it is feasible to accelerate the recovery of endothelial function and inhibit the development of existing plaques by regulating LOX-1. Herein, the surface is modified with Poly I, a LOX-1 inhibitor, using rich amino dendritic macromolecules (PAMAM) as the linker coating, to against the pathological microenvironment. Poly I modified surface resisted endothelial damage caused by oxidative stress through the LOX-1-NADPH signaling pathway and inhibited endothelial inflammation via the LOX-1-NF-κB signaling pathway. It also promoted endothelial cell migration and inhibited platelet adhesion. Moreover, the Poly I modified surface can inhibit oxLDL-induced macrophage foam cell formation and alleviate inflammation by modulating macrophage phenotypes. Poly I modified surface significantly reduced plaque burden after treatment of atherosclerotic model rats, most importantly, it significantly inhibited post-implantation-induced restenosis and thrombosis. In vivo and in vitro evaluations confirmed its safety and therapeutic efficacy against atherosclerosis. Overall, the multifunctional Poly I with pathological microenvironment regulation exhibits potential application value in the surface engineering of cardiovascular devices.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403060"},"PeriodicalIF":10.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural Macromolecule-Based Lubricative Catheter Coatings with Sustained Adaptive Antibacterial Property for Encrustation and Infection Prevention.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-18 DOI: 10.1002/adhm.202402359

Lujiao Zhang, Meizhou Sun, Weizhuo Song, Ruonan Wu, Bingran Yu, Shun Duan, Fu-Jian Xu

{"title":"Natural Macromolecule-Based Lubricative Catheter Coatings with Sustained Adaptive Antibacterial Property for Encrustation and Infection Prevention.","authors":"Lujiao Zhang, Meizhou Sun, Weizhuo Song, Ruonan Wu, Bingran Yu, Shun Duan, Fu-Jian Xu","doi":"10.1002/adhm.202402359","DOIUrl":"https://doi.org/10.1002/adhm.202402359","url":null,"abstract":"Catheter-associated urinary tract infection (CAUTI) are a global health burden. Moreover, the friction during urinary catheter placement also induces pain in patients. Therefore, there is a pressing need to develop effective antibacterial and lubricative coatings on the surface of urinary catheter. In this work, a facile volatilization film-forming method is used to construct coatings on catheter surfaces. Xanthan gum (SR), which has good lubricative and antifouling properties, is oxidized to cross-link with multi-amino compounds, gentamicin (GS), and gelatin, to fabricate uniform coatings on silicone catheters (SR-GXGs). The structures of SR-GXGs are regulated by the components of the film formation solutions. The bacterial metabolism can produce an acidic micro-environment that can regulate GS release to achieve on-demand administration. SR-GXG2 can eliminate 99.99% of common pathogenic bacteria and reduce the dynamic friction coefficient by 98.73%, and showed high stability in a 7-day flowing experiment. In addition, the universality of this method is demonstrated on various kinds of matrices with different shapes, including commercial urethral catheters. In vivo, SR-GXG2 can effectively avoid urinary tract injury and encrustation phenomenon because of its good anti-infection, antifouling, and lubricative properties. This work provides a promising strategy for developing multifunctional antibacterial coatings on medical catheters.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2402359"},"PeriodicalIF":10.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wirelessly Actuated Microfluidic Pump and Valve for Controlled Liquid Delivery in Dental Implants (Adv. Healthcare Mater. 31/2024)

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-17 DOI: 10.1002/adhm.202470198

Yilan Xu, Honglu Lin, Boyang Xiao, Hutomo Tanoto, Joel Berinstein, Alend Khoshnaw, Simon Young, Yuxiao Zhou, Xiaoguang Dong

引用次数: 0

Extracellular Vesicle-Inspired Minimalist Flexible Nanocapsules Assembled with Whole Active Ingredients for Highly Efficient Enhancement of DC-Mediated Tumor Immunotherapy (Adv. Healthcare Mater. 31/2024)

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-17 DOI: 10.1002/adhm.202470200

Ao He, Qiang Li, Meng Dang, Wei Lu, Xiaoye Li, Zhuo Dai, Meng Ding, Yu Zhang, Heng Dong, Zhaogang Teng, Yongbin Mou

引用次数: 0