Advanced Healthcare Materials最新文献

Heparin Doped Polyaniline for Anticoagulation Supercapacitors.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-04-09 DOI: 10.1002/adhm.202500493

Yuxia Zhang, Xiangya Wang, Meimei Yu, Mohammed Kamal Hadi, Suting Zhou, Yumeng Wang, Fen Ran

{"title":"Heparin Doped Polyaniline for Anticoagulation Supercapacitors.","authors":"Yuxia Zhang, Xiangya Wang, Meimei Yu, Mohammed Kamal Hadi, Suting Zhou, Yumeng Wang, Fen Ran","doi":"10.1002/adhm.202500493","DOIUrl":"https://doi.org/10.1002/adhm.202500493","url":null,"abstract":"With the rapid development of implantable electronic medical devices, supercapacitors have gained significant attention as implantable energy storage devices due to their inherent advantages. However, these devices inevitably direct contact with blood and trigger coagulation or thrombus formation when implanted in the body. In severe cases, these negative effects compromise the functionality of the implantable energy storage system and even jeopardize human health. Herein, a biocompatible electrode material with high anticoagulant activity is designed by doping polyaniline with anticoagulant macromolecule heparin under neutral conditions, which macromolecules as dopants under neutral conditions not only avoids the toxicity of acids to biological tissues and de-doping caused by small molecules, but also imparts high anticoagulant properties to the material. Based on the electrode material and in situ polymerization approach, an all-in-one anticoagulation supercapacitor is employed to manufacture and exhibits good electrochemical performance (energy density of 18.89 µWh cm-2 and a power density of 197.8 µW cm-2), cycling stability (capacitance retention of 70.23% after 2, 000 cycles), anticoagulant performance (APTT is 15.47 s, PT is 16.57 s, TT is 49.47 s, and FIB is 1.12 g L-1), and tissue compatibility. The doping strategy provides a valuable reference for energy supply in implantable bioelectronics.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2500493"},"PeriodicalIF":10.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Light/Ultrasound Dual Responsive Carbon Dots-Based Nanovaccines for Multimodal Activation Tumor Immunotherapy of Melanoma.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-04-09 DOI: 10.1002/adhm.202405194

Aijia Yang, Li Chen, Shunxin Tang, Xiaolu Guo, Hongqin Su, Bang-Ping Jiang, Xing-Can Shen

{"title":"Light/Ultrasound Dual Responsive Carbon Dots-Based Nanovaccines for Multimodal Activation Tumor Immunotherapy of Melanoma.","authors":"Aijia Yang, Li Chen, Shunxin Tang, Xiaolu Guo, Hongqin Su, Bang-Ping Jiang, Xing-Can Shen","doi":"10.1002/adhm.202405194","DOIUrl":"https://doi.org/10.1002/adhm.202405194","url":null,"abstract":"Melanoma is a highly aggressive and metastatic tumor, and immunotherapy has become the current solution. However, conventional nanovaccines do not strongly activate T cell immune responses. Therefore, development of effective therapeutic nanovaccines to activate systemic antitumor immunity is urgently required. Herein, light/ultrasound (US) dual-responsive carbon dot-based nanovaccines (Cu-N-CDs@OVA) are designed using copper-nitrogen-coordinated carbon dots composited with ovalbumin. Under 650-nm laser irradiation, Cu-N-CDs@OVA exhibited superior photothermal ablation of primary tumors, induced immunogenic cell death and released antigens by phototherapy, facilitating the maturation of dendritic cells (DCs). More importantly, Cu-N-CDs@OVA stably penetrated and diffused upon US treatment, eradicating metastatic tumors and generating low-dose reactive oxygen species to activate DCs. By integrating with the model antigen OVA, the combined multimodal treatment promotes DC maturation to activate systematic antitumor immunity. This is the first example of a light/US dual-responsive therapeutic nanovaccine that provides a paradigm for the production of personalized nanovaccines against malignant tumors.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2405194"},"PeriodicalIF":10.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasound-Mediated Biomimetic Microbubbles Effectively Reverse LSECs Capillarization and Exert Antiplatelet Therapy in Liver Fibrosis.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-04-08 DOI: 10.1002/adhm.202500196

Huan Deng, Huolin Ye, Hong Xiao, Yujia You, Xiaoyan Miao, Wei Zhang, Yifei Leng, Ronqin Zheng, Xintao Shuai, Jie Ren, Tinhui Yin

{"title":"Ultrasound-Mediated Biomimetic Microbubbles Effectively Reverse LSECs Capillarization and Exert Antiplatelet Therapy in Liver Fibrosis.","authors":"Huan Deng, Huolin Ye, Hong Xiao, Yujia You, Xiaoyan Miao, Wei Zhang, Yifei Leng, Ronqin Zheng, Xintao Shuai, Jie Ren, Tinhui Yin","doi":"10.1002/adhm.202500196","DOIUrl":"https://doi.org/10.1002/adhm.202500196","url":null,"abstract":"Liver fibrosis, characterized by excessive tissue remodeling as a response to chronic liver injury, is accompanied by capillarization of liver sinusoidal endothelial cells (LSECs) and activated hepatic stellate cells (HSCs). Simvastatin (Sim) can modulate endothelial function by increasing endothelial nitric oxide synthase (eNOS)-dependent nitric oxide (NO) release, thereby reversing capillarization and attenuating liver fibrosis. However, monotherapy often demonstrates limited therapeutic effectiveness given the complex pathophysiology of liver fibrosis. Herein, a type of multifunctional liposomal microbubbles (MBs) carrying both Sim and platelet membrane (PM) has been designed for drug delivery targeting the inflammatory LSECs, with ultrasound-targeted microbubble destruction (UTMD) to mediate efficient release of these therapeutic agents inside the liver sinusoidal. In rat liver fibrosis model, the multifunctional MBs reverses capillarization through the increase of eNOS-dependent NO production. Subsequently, the MBs adhering to the inflammatory LSECs block the adhesion and activation of inherent platelet (PLT), thereby decreasing platelet-derived growth factor β (PDGF-β) to inhibit the HSCs activation. This study demonstrates the strong therapeutic efficacy of the multifunctional MBs integrating Sim and PLT against liver fibrosis, which highlights a great potential for effectively managing this intractable chronic disease.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2500196"},"PeriodicalIF":10.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human Extracellular Matrix-Like Collagen-Based Hydrogels for Soft Tissue Regeneration and Mandibular Retrognathia Treatment.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-04-08 DOI: 10.1002/adhm.202500953

E Xiao, Peng Wang, Kaikai Zheng, Huanyu Zhong, Hui Zhou, Qiushi Liu, Xiaojing Liu, Pengju Fan, Jincheng Yao, Qiang Wei

{"title":"Human Extracellular Matrix-Like Collagen-Based Hydrogels for Soft Tissue Regeneration and Mandibular Retrognathia Treatment.","authors":"E Xiao, Peng Wang, Kaikai Zheng, Huanyu Zhong, Hui Zhou, Qiushi Liu, Xiaojing Liu, Pengju Fan, Jincheng Yao, Qiang Wei","doi":"10.1002/adhm.202500953","DOIUrl":"https://doi.org/10.1002/adhm.202500953","url":null,"abstract":"Skin aging, trauma, and congenital diseases lead to tissue defects and functional loss. Effective regeneration remains challenging due to limited material bioactivity and inadequate consideration of mechanical cues. This study develops a hydrogel integrating human extracellular matrix-like collagen (hCol) derived from induced human adipose mesenchymal stem cells (hASCs) with hyaluronic acid (HA) and polyethylene glycol diamine (PEGDA), engineered to achieve a modulus (≈1 kPa) representative of subcutaneous soft tissue. The hCol, produced at scale, provides essential biochemical signals, which, in conjunction with the hydrogel mechanical properties, synergistically modulate immune responses, cellular differentiation, and anti-aging processes. Both animal experiments and clinical trials validate the regenerative efficacy of the hydrogels. Clinical regeneration therapy for mandibular retrognathia shows rapid and sustained improvements, with repair efficacy rates of 95.2% at 3 months and 76.2% at 6 months. These findings underscore the hydrogel's ability to reshape the soft tissue microenvironment, supporting immediate tissue repair and sustained regeneration, while offering a promising platform for future biomaterial development in soft tissue engineering.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2500953"},"PeriodicalIF":10.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nitric Oxide-Mediated Dual-Functional Smart Titanium Implant Coating for Antibacterial and Osseointegration Promotion in Implant-Associated Infections.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-04-08 DOI: 10.1002/adhm.202500997

Zishuo Hou, Kun Wang, Guming Liu, Zhang Yuan, Haowei Peng, Yue Yuan, Hongbo Wei, Tengjiao Wang, Peng Li

{"title":"Nitric Oxide-Mediated Dual-Functional Smart Titanium Implant Coating for Antibacterial and Osseointegration Promotion in Implant-Associated Infections.","authors":"Zishuo Hou, Kun Wang, Guming Liu, Zhang Yuan, Haowei Peng, Yue Yuan, Hongbo Wei, Tengjiao Wang, Peng Li","doi":"10.1002/adhm.202500997","DOIUrl":"https://doi.org/10.1002/adhm.202500997","url":null,"abstract":"The balance of antibacterial and osseointegration-promoting properties on titanium (Ti) implants in a simple and efficient manner is crucial for the management of implant-associated infections, a condition that has become a significant global health concern. Herein, a nitric oxide (NO)-mediated dual-function smart coating with antibacterial and osseointegration-promoting properties is developed for Ti implants. The coating leverages the distinct properties of NO at high and low concentrations to enable an on-demand functional switch. Specifically, antibacterial function is achieved through a rapid release of high-dose NO in response to the infection microenvironment and near-infrared stimulation. Once the infection is resolved and normal physiological conditions are restored, the coating gradually releases low-dose NO to promote osseointegration. In vitro tests confirm that the coating exhibits antibacterial ratio of 97.84% and 97.18% against methicillin-resistant Staphylococcus aureus and its biofilms, respectively, and demonstrates the ability to activate osteoblasts. The rat femoral implant-associated infection model further certifies that the responsive NO release mechanism of the coating efficiently facilitates the on-demand functional switch between antibacterial and osseointegration-promoting properties. Notably, the use of the dual-functional nonantibiotic agent, NO, significantly mitigates the risk of bacterial resistance.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2500997"},"PeriodicalIF":10.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biophysically Optimized Nanofiber-Hydrogel Scaffold Composite Acts as "Bio-Bonsai" for Peripheral Nerve Simulation and Regeneration via Orienting Adipose Derived Stem Cells into Schwann-Like Cell Differentiation.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-04-08 DOI: 10.1002/adhm.202404178

Yanrong Qin, Bo Chen, Yubin Hu, Xiyu Zhang, Zihan Wang, Chengjie Ma, Ruishan Yang, Bang Wang, Fan Li, Shiwei Niu, Yi Han, Di Lu

{"title":"Biophysically Optimized Nanofiber-Hydrogel Scaffold Composite Acts as \"Bio-Bonsai\" for Peripheral Nerve Simulation and Regeneration via Orienting Adipose Derived Stem Cells into Schwann-Like Cell Differentiation.","authors":"Yanrong Qin, Bo Chen, Yubin Hu, Xiyu Zhang, Zihan Wang, Chengjie Ma, Ruishan Yang, Bang Wang, Fan Li, Shiwei Niu, Yi Han, Di Lu","doi":"10.1002/adhm.202404178","DOIUrl":"https://doi.org/10.1002/adhm.202404178","url":null,"abstract":"Efficient repairment of peripheral nerve injury (PNI) remains a severe clinical challenge worldwide, and recovering the regenerative capability of neurons in peripheral nervous system is hindered by the slow rate and inaccurate direction of axonal elongation. Schwann cells (SCs) loaded nerve guidance conduit has been proven to improve PNI repair, but the low cell survival rate and incomplete differentiation of SCs limited its practical application. To address these hurdles, a biophysically optimized nanofiber-hydrogel scaffold composite (APML@PC) is prepared in this study, the \"bio\"bonsai\"\"inspired strategy integrates topological and biological cues to promote adipose-derived mesenchymal stem cells (ADSCs) adhesion, proliferation, and Schwann-like cell differentiation. In vitro and in vivo experiments confirmed the favorable biocompatibility and reasonable biodegradation behavior of this inducible platform, and the robust capability to promote axonal growth, remyelination regeneration, as well as nerve function recovery. This novel composite can serve as a promising candidate for the development of advanced stem cell-based peripheral nerve regeneration, thereby paving a new avenue for clinically effective PNI therapy.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2404178"},"PeriodicalIF":10.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Wireless Cortical Surface Implant for Diagnosing and Alleviating Parkinson's Disease Symptoms in Freely Moving Animals.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-04-08 DOI: 10.1002/adhm.202405179

Hongseong Shin, Kyungtae Kim, Jaeseung Lee, Johyeon Nam, Eunha Baeg, Chaeyeon You, Hanseul Choi, Minji Kim, Chun Kee Chung, Jae Geun Kim, Jong Hyun Ahn, Miryung Han, Jibum Kim, Sungchil Yang, Sung Q Lee, Sunggu Yang

{"title":"A Wireless Cortical Surface Implant for Diagnosing and Alleviating Parkinson's Disease Symptoms in Freely Moving Animals.","authors":"Hongseong Shin, Kyungtae Kim, Jaeseung Lee, Johyeon Nam, Eunha Baeg, Chaeyeon You, Hanseul Choi, Minji Kim, Chun Kee Chung, Jae Geun Kim, Jong Hyun Ahn, Miryung Han, Jibum Kim, Sungchil Yang, Sung Q Lee, Sunggu Yang","doi":"10.1002/adhm.202405179","DOIUrl":"https://doi.org/10.1002/adhm.202405179","url":null,"abstract":"Parkinson's disease (PD), one of the most common neurodegenerative diseases, is involved in motor abnormality, primarily arising from the degeneration of dopaminergic neurons. Previous studies have examined the electrotherapeutic effects of PD using various methodological contexts, including live conditions, wireless control, diagnostic/therapeutic aspects, removable interfaces, or biocompatible materials, each of which is separately utilized for testing the diagnosis or alleviation of various brain diseases. Here, a cortical surface implant designed to improve motor function in freely moving PD animals is presented. This implant, a minimally invasive system equipped with a graphene electrode array, is the first integrated system to exhibit biocompatibility, wearability, removability, target specificity, and wireless control. The implant positioned at the motor cortical surface activates the motor cortex to maximize therapeutic effects and minimize off-target effects while monitoring motor activities. In PD animals, cortical motor surface stimulation restores motor function and brain waves, which corresponds to potentiated synaptic responses. Furthermore, these changes are associated with the upregulation of metabotropic glutamate receptor 5 (mGluR5, Grm5) and D5 dopamine receptor (D5R, Drd5) genes in the glutamatergic synapse. The newly designed wireless neural implant demonstrates capabilities in both real-time diagnostics and targeted therapeutics, suggesting its potential as a wireless system for biomedical devices for patients with PD and other neurodegenerative diseases.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2405179"},"PeriodicalIF":10.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developing Therapeutically Enhanced Extracellular Vesicles for Atherosclerosis Therapy.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-04-07 DOI: 10.1002/adhm.202404398

Neil Patel, Elijah Avery, Yi Huang, Eun Ji Chung

{"title":"Developing Therapeutically Enhanced Extracellular Vesicles for Atherosclerosis Therapy.","authors":"Neil Patel, Elijah Avery, Yi Huang, Eun Ji Chung","doi":"10.1002/adhm.202404398","DOIUrl":"https://doi.org/10.1002/adhm.202404398","url":null,"abstract":"Atherosclerosis is a chronic condition and the leading cause of death worldwide. While statin therapy is the clinical standard, many patients still experience acute cardiovascular events. To develop better therapies, the group previously delivered microRNA-145 (miR-145) via micellar nanoparticles to vascular smooth muscle cells (VSMCs) to inhibit atherosclerosis. However, for chronic diseases requiring repeat dosing, synthetic nanoparticles have drawbacks such as immunogenic response and low delivery efficiency. To meet this challenge, therapeutically enhanced extracellular vesicles (EVs) are engineered as a biologically-derived nanoparticle modality to mitigate atherosclerosis. A novel strategy is employed to load miR-145 into EVs using ExoMotifs-short miRNA sequences that facilitate miR cargo loading. EVs are further functionalized with a monocyte chemoattractant 1 (MCP-1) peptide, which binds to C-C chemokine receptor 2 upregulated in pathogenic VSMCs. Mouse aortic smooth muscle cell MCP-1-miR-145 EVs restored VSMC gene expression and function in vitro. Moreover, compared to miR-145-loaded synthetic nanoparticles, MCP-1-miR-145 EVs exerted similar therapeutic effects but with 25,000x less miR-145 cargo. Lastly, MCP-1-miR-145 EVs inhibited plaque growth in mid-stage ApoE-/- atherosclerotic mice at a miR-145 dose 5000x less than synthetic nanoparticles. Collectively, it is demonstrated that genetic engineering of VSMCs with miR-145 produces therapeutically boosted EVs that reduce atherosclerosis plaque burden.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2404398"},"PeriodicalIF":10.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fe/Cu Bimetallic Nanozyme Co-Assembled with 177Lu and Tanshinone for Quadruple-Synergistic Tumor-Specific Therapy (Adv. Healthcare Mater. 9/2025)

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-04-07 DOI: 10.1002/adhm.202570054

Xianyu Zhu, Lingling Zheng, Pengfei Zhao, Lingli Gao, Liang Wang, Jun Liu, Xu Yang, Hanrui Wei, Mingyu Zhang, Liang Yan, Han Lv, Jianhua Gong, Ji gang Yang, Zhenchang Wang

引用次数: 0

Interpenetrating Polymer Network Hydrogels with Tunable Viscoelasticity and Proteolytic Cleavability to Direct Stem Cells In Vitro (Adv. Healthcare Mater. 9/2025)

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-04-07 DOI: 10.1002/adhm.202570055

Prannoy Seth, Jens Friedrichs, Yanuar Dwi Putra Limasale, Nicole Fertala, Uwe Freudenberg, Yixin Zhang, Ayala Lampel, Carsten Werner

引用次数: 0