Advanced Healthcare Materials最新文献

Coassembled Perylene-Carbohydrate Conjugates Exert Antibiotic-Free Antibacterial Effects and Enhance the Effects of Photothermal Therapy by Targeting LecA/LecB Lectins. 共聚苝-碳水化合物偶联物通过靶向LecA/LecB凝集素发挥无抗生素抗菌作用并增强光热治疗效果。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-06-27 DOI: 10.1002/adhm.202404859

Jian-Xing Yang, Fangqian Yin, Hai-Qing Li, Gao-Juan Lin, Wen-Juan Yin, Xiao-Liu Li, Ke-Rang Wang

{"title":"Coassembled Perylene-Carbohydrate Conjugates Exert Antibiotic-Free Antibacterial Effects and Enhance the Effects of Photothermal Therapy by Targeting LecA/LecB Lectins.","authors":"Jian-Xing Yang, Fangqian Yin, Hai-Qing Li, Gao-Juan Lin, Wen-Juan Yin, Xiao-Liu Li, Ke-Rang Wang","doi":"10.1002/adhm.202404859","DOIUrl":"https://doi.org/10.1002/adhm.202404859","url":null,"abstract":"Pathogenic infections are a global threat to human health. In particular, the treatment of Psuedomonas aeruginosa infection remains particularly challenging. Interestingly, the LecA and LecB lectins of P. aeruginosa play crucial roles in bacterial adhesion, biofilm formation, virulence, and host cell invasion. Herein, two kinds of perylene-carbohydrate conjugates (PMI-3Gal and PMI-3Fuc) that simultaneously target LecA and LecB in P. aeruginosa are coassembled to prepare antibiotic-free antibacterial and antibiofilm agents. Owing to the strong multivalent carbohydrate-lectin interactions for both LecA and LecB lectins, the coassembled PMI-3Gal@PMI-3Fuc shows selective adhesion effects, inhibits biofilm formation, demonstrates potent photothermal antibacterial activities for P. aeruginosa and a clinically isolated P. aeruginosa strain, and accelerates wound healing in mice. These findings provide new insight into the development of multivalent glycoconjugates that have antibiotic-free antibacterial and antibiofilm effects.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2404859"},"PeriodicalIF":10.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PLUS: Primary Layer for Universal Sensing Enabling Improved Immunocapture of Biomarkers in Clinical Scenarios. PLUS：通用传感的初级层，可在临床场景中改善生物标志物的免疫捕获。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-06-27 DOI: 10.1002/adhm.202501281

Nayoung Son, Chorok Byeon, Haejin Jeong, Hyeonha Jang, Jun Seok Park, Seonki Hong

{"title":"PLUS: Primary Layer for Universal Sensing Enabling Improved Immunocapture of Biomarkers in Clinical Scenarios.","authors":"Nayoung Son, Chorok Byeon, Haejin Jeong, Hyeonha Jang, Jun Seok Park, Seonki Hong","doi":"10.1002/adhm.202501281","DOIUrl":"https://doi.org/10.1002/adhm.202501281","url":null,"abstract":"The biofunctionalization of sensor surfaces to enable biorecognition capabilities remains a major challenge in developing diagnostic devices. However, efficient surface chemistries applicable to various sensor types remain elusive. In this study, Primary Layer for Universal Sensing (PLUS), a universal coating for bioprobe immobilization designed to enhance sensor functionality across diverse substrates, is introduced. Derived from the mussel-inspired, catechol-based adhesive polydopamine (pDA), PLUS ensures material-independent coating ability. Unlike conventional methods that involve secondary bioprobe immobilization onto a pre-formed pDA layer, PLUS is directly grown from dopamine (DA) and avidin proteins as co-polymerization precursors, resulting in a highly roughened surface with abundant biotin-binding sites. This strategy, combined with end-functionalization using biotinylated antibodies, significantly enhances immunocapture efficiency compared to traditional immunoassays. Furthermore, the PLUS layer interacts effectively with blocking proteins, preventing non-specific binding of unwanted molecules. This ensures reliable biomarker capture even in complex biological samples, such as 50% human serum and plasma. It is envisioned that this bioprobe immobilization technique will play a pivotal role in advancing high-performance sensor adaptability for molecular diagnostics.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2501281"},"PeriodicalIF":10.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing the Pharmacokinetics of Aptamers: Targeting AXL In Vivo Using a Bottlebrush Polymer-Conjugated Aptamer. 增强适体的药代动力学：使用瓶刷聚合物共轭适体靶向体内AXL。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-06-26 DOI: 10.1002/adhm.202405083

Tingyu Sun, Jiachen Lin, Chenyang Xue, Yuyan Wang, Peiru Chen, Yun Wei, Guobin Xu, Anais Sidonia, Chris Nenopoulos, Hossam Tashkandi, Caroline Shen, Allison Wang, Alex Wang, Ke Zhang

{"title":"Enhancing the Pharmacokinetics of Aptamers: Targeting AXL In Vivo Using a Bottlebrush Polymer-Conjugated Aptamer.","authors":"Tingyu Sun, Jiachen Lin, Chenyang Xue, Yuyan Wang, Peiru Chen, Yun Wei, Guobin Xu, Anais Sidonia, Chris Nenopoulos, Hossam Tashkandi, Caroline Shen, Allison Wang, Alex Wang, Ke Zhang","doi":"10.1002/adhm.202405083","DOIUrl":"https://doi.org/10.1002/adhm.202405083","url":null,"abstract":"The overexpression of receptor tyrosine kinase AXL receptor tyrosine kinase (AXL) is linked to acquired drug resistance in cancer treatments. Aptamers, acting as antibody surrogates, have been envisioned as potential inhibitors for AXL. However, aptamers face difficult pharmacological challenges including rapid degradation and clearance. Herein, a phosphodiester-backboned bottlebrush polymer is reported as a carrier for conjugated aptamers. Termed polymer-augmented conjugates of DNA (pacDNA), the conjugate improves aptamer specificity in vivo, prolongs blood retention, and enhances overall aptamer bioactivity. Treatment with pacDNA in AXL-overexpressing cell lines significantly inhibits AXL phosphorylation, resulting in reduced cancer cell migration and invasion. In a non-small cell lung cancer xenograft model (NCI-H1299), pacDNA treatment leads to single-agent reduction in tumor growth. These results highlight the potential of bottlebrush polymers in the field of aptamer therapeutics.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2405083"},"PeriodicalIF":10.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CXCR4 Clustering Induced by Polymeric Nanothreads Impedes Cancer Cell Metastasis via PIEZO1-Mediated Mechanotransduction. 聚合纳米线诱导的CXCR4聚类通过piezo1介导的机械转导阻碍癌细胞转移。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-06-26 DOI: 10.1002/adhm.202501072

Junzhu Shi, Chendong Liu, Jiaqi Liu, Yue Yan, Fengju Wang, Shenao Yan, Yucheng Xiang, Minglu Zhou, Yining Xu, Lian Li

{"title":"CXCR4 Clustering Induced by Polymeric Nanothreads Impedes Cancer Cell Metastasis via PIEZO1-Mediated Mechanotransduction.","authors":"Junzhu Shi, Chendong Liu, Jiaqi Liu, Yue Yan, Fengju Wang, Shenao Yan, Yucheng Xiang, Minglu Zhou, Yining Xu, Lian Li","doi":"10.1002/adhm.202501072","DOIUrl":"https://doi.org/10.1002/adhm.202501072","url":null,"abstract":"The way in which the antagonist binds to the target molecule affects the intervention of its downstream pathway. Previously, an antagonistic strategy for CXC chemokine receptor 4 (CXCR4) utilizing two polymeric nanothreads is developed that self-assemble into patches on the cell surface. These patches induce CXCR4 clustering, leading to a significantly enhanced antagonism compared to conventional monovalent or multivalent receptor binding. However, the underlying mechanism remains unclear. Here, the critical role of Piezo Type Mechanosensitive Ion Channel Component 1 (PIEZO1) is revealed, a mechanically sensitive ion channel protein, in mechanotransduction during CXCR4 clustering-mediated antagonism. It is shown that the nanothreads patching on the cell surface trigger F-actin rearrangement, and generates mechanical stress, which subsequently activates PIEZO1. Conversely, the application of a PIEZO1 inhibitor significantly attenuates the CXCR4 antagonistic effect of nanothreads patching, resulting in less inhibition of downstream activities associated with epithelial-to-mesenchymal transition of cancer cells and their metastasis both in vitro and in vivo. This result highlights the involvement of PIEZO1-mediated mechanotransduction in amplifying CXCR4 antagonism through triggering receptor clustering.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2501072"},"PeriodicalIF":10.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantum Dot Nanoprobes for Microvascular Thromboembolism Therapy via Ultrasound and Near-Infrared Dual-Mode Approach. 量子点纳米探针通过超声和近红外双模方法治疗微血管血栓栓塞。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-06-26 DOI: 10.1002/adhm.202500315

Zhixin Jiang, Nan Jiang, Mengying Sun, Zhiwen Wang, Yuxin Guo, Bin Gui, Yueying Chen, Zhiquan Tian, Bo Hu

{"title":"Quantum Dot Nanoprobes for Microvascular Thromboembolism Therapy via Ultrasound and Near-Infrared Dual-Mode Approach.","authors":"Zhixin Jiang, Nan Jiang, Mengying Sun, Zhiwen Wang, Yuxin Guo, Bin Gui, Yueying Chen, Zhiquan Tian, Bo Hu","doi":"10.1002/adhm.202500315","DOIUrl":"https://doi.org/10.1002/adhm.202500315","url":null,"abstract":"Thromboembolism can lead to ischemic damage in vital organs and, in severe cases, become life-threatening. A major challenge in its treatment is that, despite conventional clinical therapies, thromboembolic occlusions in the microvasculature often persist, making them difficult to remove completely and effectively, with limited improvement in patient outcomes. In this study, a novel approach to treating microvascular thromboembolism is proposed by utilizing the imaging and photothermal properties of quantum dots. Using mesoporous silica nanoparticles (MSN) as a controlled-release carrier, the nanoprobes are functionalized with arginine-glycine-aspartate sequence (RGD) (specifically target αIIbβ3 integrin receptors on activated platelets) and are loaded internally with Ag2Te quantum dots and perfluoropentane (PFP) (thrombolysis enhancement via cavitation). The Ag2Te quantum dot-based nanoprobes responsive to both ultrasound and near-infrared (NIR) irradiation are developed, establishing a dual-modal diagnostic and therapeutic system for addressing microvascular thromboembolism. Through in vitro and in vivo experiments, along with safety evaluations, these nanoprobes, which are successfully developed, capitalize on the superior NIR imaging and photothermal thrombolytic capabilities of Ag2Te quantum dots. The RGD/Ag2Te/PFP@MSN nanoprobe enables targeted, precise tracking and synergistic dual-modal thrombolysis for microvascular thromboembolism. The study highlights the significant translational potential of this approach for the diagnosis and treatment of thromboembolic conditions.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2500315"},"PeriodicalIF":10.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Semiconducting Polymer Nanoparticles as Multimodal Agents for Optical and Magnetic Resonance Imaging. 半导体聚合物纳米颗粒作为光学和磁共振成像的多模态试剂。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-06-26 DOI: 10.1002/adhm.202500195

Faysal A Farah, Yu Qin, Mark A Green, James D E T Wilton-Ely

引用次数: 0

Virus-Inspired Nanoparticles for Intensified Cancer Therapy via Cascade Reinforcement of "Nontoxicity-to-Toxicity" Transition and Mitochondrial Dysfunction. 病毒激发的纳米颗粒通过级联强化“无毒到毒性”过渡和线粒体功能障碍加强癌症治疗。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-06-26 DOI: 10.1002/adhm.202405274

Yueyang He, Jinyan Lin, Cailin Huang, Qingdong Bao, Zhankun Hao, Sihan Zhao, Wenlong Li, Hui Zhu, Xiaoyang Zhai

{"title":"Virus-Inspired Nanoparticles for Intensified Cancer Therapy via Cascade Reinforcement of \"Nontoxicity-to-Toxicity\" Transition and Mitochondrial Dysfunction.","authors":"Yueyang He, Jinyan Lin, Cailin Huang, Qingdong Bao, Zhankun Hao, Sihan Zhao, Wenlong Li, Hui Zhu, Xiaoyang Zhai","doi":"10.1002/adhm.202405274","DOIUrl":"https://doi.org/10.1002/adhm.202405274","url":null,"abstract":"Mitochondria play an essential role in cellular oxidative stress defense. Mitochondrial impairment results in disrupted intracellular redox balance and tumor cell apoptosis. Herein, a biodegradable nanoprobe for combination chemotherapy is constructed by developing a virus-like mesoporous copper oxide nanocage co-loaded with disulfiram (DSF) and berberine (BBR) to amplify oxidative stress. This nanoparticle can be efficiently endocytosed by tumor cells due to its biomimetic virus-like morphology and has shown effective intracellular degradation to release BBR, DSF, and Cu2+. The released BBR directly promotes cellular vulnerabilities and mitochondrial damage. In addition, the DSF and Cu2+ chelate in situ to generate highly toxic CuET, achieving a \"nontoxic-to-toxic\" transformation and triggering the generation of reactive oxygen species (ROS). Due to the mitochondrial dysfunction induced by BBR, massive ROS accumulation is noted within tumor cells, which in turn exacerbates mitochondrial damage and further disrupts intracellular redox balance in a positive feedback loop, inducing tumor cell apoptosis. In this study, a mitochondria-based nanoparticle with intracellular \"nontoxic-to-toxic\" transformation ability is constructed, amplifying oxidative stress in tumor cells for combination chemotherapy with high biosafety.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2405274"},"PeriodicalIF":10.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrospun Scaffold Co-Modified with YIGSR Peptide and Heparin for Enhanced Skin Wound Healing. YIGSR肽和肝素共修饰的电纺丝支架促进皮肤伤口愈合。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-06-26 DOI: 10.1002/adhm.202501745

Zhijin Li, Hui Sun, Zhun Yin, Xiaoting Shi, Ruobing Zhao, Wei Wang, Yuhe Zhu

{"title":"Electrospun Scaffold Co-Modified with YIGSR Peptide and Heparin for Enhanced Skin Wound Healing.","authors":"Zhijin Li, Hui Sun, Zhun Yin, Xiaoting Shi, Ruobing Zhao, Wei Wang, Yuhe Zhu","doi":"10.1002/adhm.202501745","DOIUrl":"https://doi.org/10.1002/adhm.202501745","url":null,"abstract":"Angiogenesis is a critical step in biomaterial-assisted skin tissue regeneration, as it ensures adequate oxygen and nutrient supply to the wound site, facilitating cellular proliferation and tissue remodeling. Electrospun polycaprolactone/gelatin (PG) scaffolds exhibit good biocompatibility and biodegradability; however, their bio-inert nature limits their applications. To enhance the angiogenic properties of PG scaffolds, this study aimed to develop a novel biomaterial by co-modifying electrospun PG scaffolds (PGHY) with YIGSR peptide and heparin. YIGSR, a laminin-derived peptide, serves as an endothelial cell-specific adhesion sequence, while heparin acts as a peptide reservoir, facilitating retention and controlled release. In vitro experiments demonstrated that among three peptide-loading concentrations, PGHY1.0 scaffold exhibited stable peptide release and promoted endothelial cell proliferation, migration, and tube formation via the FAK/MAPK/ERK1/2 signaling pathway. In vivo results further confirmed that the PGHY1.0 scaffold enhanced angiogenesis in murine dorsal skin defects, accelerating wound healing. Overall, the PGHY1.0 scaffold, with its excellent biocompatibility and pro-angiogenic properties, presents a promising therapeutic strategy for skin tissue regeneration.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2501745"},"PeriodicalIF":10.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DNA Barcoding-Enabled Tracking of Lipid Nanoparticles: Drug-Loading-Dependent Biodistribution and Tumor Microenvironment Targeting. DNA条形码支持脂质纳米颗粒的跟踪：药物负载依赖的生物分布和肿瘤微环境靶向。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-06-26 DOI: 10.1002/adhm.202501914

Letao Xu, Rui Chen, Xing Wang, Dawei Liu, Yun Liu, Chun-Xia Zhao

{"title":"DNA Barcoding-Enabled Tracking of Lipid Nanoparticles: Drug-Loading-Dependent Biodistribution and Tumor Microenvironment Targeting.","authors":"Letao Xu, Rui Chen, Xing Wang, Dawei Liu, Yun Liu, Chun-Xia Zhao","doi":"10.1002/adhm.202501914","DOIUrl":"https://doi.org/10.1002/adhm.202501914","url":null,"abstract":"Lipid nanoparticles (LNPs) are versatile drug delivery systems, yet the impact of drug loading (DL) on their biodistribution and cellular uptake remains poorly understood. Optimizing drug loading is crucial for enhancing therapeutic efficacy and safety, as higher loading allows for lower LNP doses, reducing overall nanomaterial burden. Addressing this knowledge gap is essential for advancing LNP-based cancer therapies. This study integrates DNA barcoding technology with LNPs to evaluate their in vivo delivery behaviors under varying drug loadings. Using a sequential nanoprecipitation method, DNA-barcoded LNPs with low (1%), medium (16%), and high (26%) drug loadings are fabricated, each tagged with a unique DNA barcode for precise tracking. Pooled LNPs are intravenously administered to tumor-bearing mice, and their biodistribution across organs is quantified via qPCR. High drug-loading LNPs demonstrate preferential accumulation in the spleen, while low drug-loading LNPs exhibit higher liver accumulation, suggesting faster clearance. Cellular uptake analysis reveals enhanced uptake of high drug-loading LNPs by tumor-associated macrophages within the tumor microenvironment (TME). This study establishes a robust platform for simultaneous and high-sensitivity monitoring of LNP behaviors, significantly reducing animal use and interanimal variability. The findings guide the rational design for developing optimal LNPs for cancer therapies targeting specific TME components.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2501914"},"PeriodicalIF":10.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Multifunctional MXene@CeO₂-Enhanced Hydrogel Dressing for Synergistic Photothermal Antibacterial and Antioxidative Therapy in Wound Healing. 一种用于伤口愈合协同光热抗菌和抗氧化治疗的多功能MXene@CeO2-Enhanced水凝胶敷料。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-06-26 DOI: 10.1002/adhm.202500656

Qianyu Guo, Miaomiao Zhang, Jinyao Zheng, Zongjia Li, Yuanhao Zhang, Ying Chen, Yu Chen, Xiue Jiang, Jilin Tang

{"title":"A Multifunctional MXene@CeO2-Enhanced Hydrogel Dressing for Synergistic Photothermal Antibacterial and Antioxidative Therapy in Wound Healing.","authors":"Qianyu Guo, Miaomiao Zhang, Jinyao Zheng, Zongjia Li, Yuanhao Zhang, Ying Chen, Yu Chen, Xiue Jiang, Jilin Tang","doi":"10.1002/adhm.202500656","DOIUrl":"https://doi.org/10.1002/adhm.202500656","url":null,"abstract":"Chronic wounds infected with drug-resistant bacteria present a formidable clinical challenge, exacerbated by antibiotic overuse that severely compromises healing. Herein, a multifunctional therapeutic hydrogel wound dressing is developed to address these challenges. This advanced nanocomposite hydrogel incorporates cerium dioxide-doped MXene nanosheets (MXene@CeO2) within a glycidyl methacrylate-modified gelatin (GMA-Gelatin) matrix and crosslinked into a hydrogel under UV irradiation (GMAG-GEL), forming a near-infrared (NIR)-responsive material (MXene@CeO2/GMAG-GEL). This incorporation enhances the mechanical strength of the hydrogel and creates a protective microenvironment for wound repair. In the acidic environment of bacterial infections, MXene@CeO2/GMAG-GEL facilitates the electrostatic capture of bacteria. Synergizing with its photothermal capability, it exhibits exceptional antibacterial activity, effectively killing drug-resistant bacteria and disrupting bacterial biofilms. After eradicating the infection, MXene@CeO2/GMAG-GEL further alleviates oxidative stress, promotes cell migration and angiogenesis, and induces macrophage polarization toward an anti-inflammatory phenotype. In vivo studies confirmed MXene@CeO2/GMAG-GEL significantly accelerates wound closure and tissue regeneration. This work overcomes the key challenges of antibiotic resistance, persistent inflammation, and impaired tissue regeneration, presents a comprehensive therapeutic strategy for drug-resistant bacterial wound infections through a single multifunctional platform.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2500656"},"PeriodicalIF":10.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0