Advanced Healthcare Materials最新文献

{"title":"Engineering of Glioblastoma-Derived Biomimetic Vesicles and Their Structural and Molecular Features.","authors":"Noelia Hernández-Lobato, Hanan Abumanhal-Masarweh, Martí de Cabo, Pablo Guerra, Marilena Hadjidemetriou, Neus Lozano, Kostas Kostarelos","doi":"10.1002/adhm.202503775","DOIUrl":"https://doi.org/10.1002/adhm.202503775","url":null,"abstract":"<p><p>Biomimetic nanosystems and vesicles have arisen as a novel approach to design vesicular transport systems with diverse therapeutic potential. The 'biomimetic' strategy involves the integration of cell membrane components into lipid bilayers, conferring them with biological properties originating from the cell of origin. Until now, most studies have primarily focused on the evaluation of the biological activity and function of different biomimetic nanosystems with limited exploration of the engineering parameters selected and little characterization of their features at the molecular level. This study aimed to address this knowledge gap by describing a preparation method for biomimetic lipid vesicles using traditional liposome fabrication principles and cellular components exclusively derived from glioblastoma (GL261) cell membrane proteins. Critical engineering parameters were studied, such as bilayer lipid and cholesterol content, the degree of surface PEGylation and some processing aspects like purification and quantification. Following fabrication, the GL261-derived vesicles underwent purification using size exclusion chromatography to separate unbound proteins from the vesicles. Subsequently, the GL261-derived vesicles were characterized by cryo-EM and differential scanning calorimetry (DSC) to assess their morphological and thermal properties, respectively. Both cholesterol and PEGylated lipid content played an important role on the structural and colloidal features of the biomimetic vesicles (BV). Mass spectroscopy (LC-MS/MS) revealed the proteomic signature of the fabricated vesicles at the molecular level. Collectively, these findings advance the rational engineering of BV and offer an in-depth proteomic framework that reveals their molecular identity and functional potential. By connecting the design principles of fabrication with the molecular features of the vesicles, this study paves the way for next-generation biomimetic platforms for cancer chemotherapy, immunomodulation and cancer vaccination.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e03775"},"PeriodicalIF":9.6,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147855494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ion-Mediated Regulation of Helical Gold Nanorods With Chirality-Photothermal Properties for Targeted Cancer Therapy.","authors":"Hang Li, Wen Li, Zikang Chen, Gaojia Qin, Ming Li, Ying Sun, Yibo Zhao, Jianli Lin, Caiping Ding, Youju Huang","doi":"10.1002/adhm.71233","DOIUrl":"https://doi.org/10.1002/adhm.71233","url":null,"abstract":"<p><p>Chiral plasmonic gold nanomaterials held significant promise for tumor photothermal therapy, with their helical pitch depth playing a critical role in determining both chirality and photothermal performance. However, precise pitch depth control remained a major challenge. Herein, we reported a Br^--chiral ligand cooperative strategy to synthesize near-infrared-responsive helical chiral Au nanorods (Au NRs) with finely tunable pitch depths. Systematic investigations revealed distinct ion-regulation mechanisms: Br^- selectively passivated [100] facets to promote [111] anisotropic growth of; I^-/Cu²⁺ strongly adsorbed onto [111] to suppress helical development, Fe³⁺ only altered ligand adsorption without impeding [111] growth. These findings established directional [111] growth as a fundamental for both pitch-depth engineering and chiral structure formation. Optimized chiral Au NRs exhibited a high g-factor of 0.026, a >3-fold stronger localized electromagnetic field, and 16% higher photothermal conversion efficiency with reversibility. In vitro studies show 94% cellular uptake in HepG2 and near-complete cancer ablation under 808 nm irradiation, and high normal cell viability. This work elucidated ion-specific modulation roles, established a \"pitch depth-chirality-performance-outcome\" correlation, and provided design principles for precision photothermal therapy and chiral sensing.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71233"},"PeriodicalIF":9.6,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endogenous Shear-Responsive Chemiluminescence Theranostics for Self-Illuminating Thrombosis Imaging and Piezo-Photodynamic Therapy.","authors":"Wenxiong Cao, Qibo Fang, Pan Ran, Huan Zheng, Shuang Xie, Yuan Liu, Xiaohong Li","doi":"10.1002/adhm.71238","DOIUrl":"https://doi.org/10.1002/adhm.71238","url":null,"abstract":"<p><p>Thrombotic diseases represent a major global health challenge, yet current theranostic systems suffer from bleeding risks, rapid agent clearance, and external irradiation reliance. To tackle these issues, we developed a shear stress-responsive platform integrating endogenous piezoelectric thrombolysis and on-site chemiluminescence imaging. Specifically, calcium-/zirconium-doped barium titanate (BCTZ) nanorods (NRs) modified with chlorin e6 (Ce6), luminol, and Arg-Gly-Asp (RGD) peptides, yielding BCTZ@CeLu-R NRs. A strong correlation is demonstrated between piezoelectric potentials and the degree of stenosis, providing rational mechanical signals for stenosis-adaptive thrombus imaging and thrombolysis. The shear force-triggered piezocatalysis operates according to energy band theory, as evidenced by thoroughly monitoring degradation rates of various dyes in media with different pH values. Piezocatalysis of NRs primarily generates ·OH and ·O₂ ^- to oxidize luminol and generate chemiluminescence, which, in turn, activates Ce6 to emit fluorescence for imaging and producing ¹O₂ for photodynamic therapy (PDT), creating a piezocatalysis-chemiluminescence-energy transfer cascade. In a rat model of carotid artery thrombosis, RGD-targeted NRs achieve four-fold higher luminescence for deep-tissue imaging without external excitation, and combined piezocatalysis, PDT, and RGD-mediated targeting realize 97.7% thrombolysis efficiency. This work pioneers an innovative theranostic approach driven by endogenous shear force, enabling clot site-specific and stenosis degree-adaptive thrombosis imaging and thrombus dissolution.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71238"},"PeriodicalIF":9.6,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147855420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Glucose-Fueled Metal-Organic Framework@Nanofiber Membrane Enables Self-Activated Chemodynamic-Photodynamic Therapy for Diabetic Infections.","authors":"Liefeng Hu, Yahuan Wang, Yan Liu, Ganlin Dong, Jiayi Luo, Shuting Li, Zihan Wang, Yu-Qi Feng","doi":"10.1002/adhm.71234","DOIUrl":"https://doi.org/10.1002/adhm.71234","url":null,"abstract":"<p><p>Chemodynamic therapy (CDT) and photodynamic therapy (PDT) mediated by reactive oxygen species hold great potential for wound infection management due to their independence from antibiotic resistance. However, chronic wounds with pH > 8 and inadequate H₂O₂ impair the catalytic efficiency required for CDT, and external light irradiation required for PDT damages normal tissues and hinders wound healing. We herein develop a MOF@nanofiber membrane that enables a precise and efficient combination of controlled self-activated CDT and PDT for diabetic infections. Shuttle-shaped PCN-222 MOF nanoparticles act as photosensitizers and platforms for in situ growth of Au nanoparticles with glucose oxidase-like activity and encapsulation of luminol (Lum). These components are integrated into electrospun nanofibrous membranes composed of polyvinyl alcohol and hyaluronic acid, and crosslinked with Fe²⁺ to obtain LPA@PHM(Fe). Mechanistically, the membrane is degraded by bacteria-secreted hyaluronidase and H₂O₂ in infected wounds, producing ·OH and releasing LPA. Au NPs then lower local glucose and pH, and supplement H₂O₂ to enhance CDT and enable Lum-based chemiluminescence resonance energy transfer-mediated PDT. This synergistic antimicrobial effect is verified in vitro and in diabetic wounds. Applied as a band-aid, LPA@PHM(Fe) shows strong potential for promoting healing of diabetic infected wounds.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71234"},"PeriodicalIF":9.6,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147830968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physicochemical Reinforcement Unlocks Sterilization-Stable Anisotropic Hydrogels for Cell-Compatible Mock Arteries.","authors":"Javiera Sanhueza Ortega, Kirthen Shanmuganathan, Laura Poole-Warren, Susann Beier, Ulises Aregueta Robles","doi":"10.1002/adhm.202600010","DOIUrl":"https://doi.org/10.1002/adhm.202600010","url":null,"abstract":"<p><p>In vitro arterial models offer ethical and robust alternatives for vascular research but require cytocompatible materials that replicate physiological mechanics. Poly(vinyl alcohol) (PVA) hydrogels produced by directional freezing and salting-out (PVA DFSO) are anisotropic yet lack stability for cell culture. Herein, methacrylated PVA (PVA-MA) hydrogels were fabricated by integrating directional freezing, salting-out, and ultraviolet (UV)-mediated covalent crosslinking to enhance mechanical performance and physicochemical stability. Two fabrication routes were examined: UV polymerization before (UVBSO) or after (UVASO) salting-out. Tensile properties and anisotropy were quantified relative to the freezing direction, and stability was assessed by swelling and mass-loss measurements. UVBSO hydrogels achieved the highest anisotropy (ratio ≈ 3.48), with Young's modulus of 50.8 kPa parallel (E||) and 14.1 kPa perpendicular (E⊥) to freezing direction but reduced stiffness (2.9-fold lower E∥ than DFSO). In contrast, UVASO constructs demonstrated robust, arterial-range performance (tensile strength ≈ 760 kPa; E∥ ≈ 378.6 kPa; ∼2.5-fold vs DFSO; ratio ≈ 3.26), reduced swelling without increasing mass loss, and sterilization compatibility. PVA-MA hydrogels could be molded into artery-like geometries and supported viable cell adhesion. This work presents a sterilizable, cytocompatible hydrogel with tunable anisotropy and arterial-mimetic mechanics, advancing the development of vascular-relevant in vitro artery models.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e00010"},"PeriodicalIF":9.6,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PAM@GO Composite Scaffolds Enhance the Yield of iMEC Exosomes for Accelerated Burn Repair.","authors":"Zhigang Lei, Shan Deng, Zhe Sun, Quanhui Liu, Hong Pan, Guodong Wang, Jinmiao Pan, Ben Huang, Dandan Zhang","doi":"10.1002/adhm.202505468","DOIUrl":"https://doi.org/10.1002/adhm.202505468","url":null,"abstract":"<p><p>Severe burns trigger widespread tissue necrosis and a persistent inflammatory cascade, demanding the development of advanced biomaterials capable of actively promoting cutaneous regeneration. In this study, we present a multifunctional hydrogel system integrating a polyacrylamide-graphene oxide (PAM@GO) matrix, capable of promoting induced mammary epithelial-like cells (iMECs) to achieve the high-yield production of exosomes (PAM@GO-EXOs-iMECs), and enhance the biological functions. Mechanistically, iMECs exosome biogenesis can be enhanced by both activating RAB27A/B-mediated vesicular trafficking and upregulating the critical MITF-NSMASE2 signaling axis. Furthermore, in vitro assays demonstrated that PAM@GO-EXOs-iMECs significantly stimulated keratinocyte proliferation and migration, alongside robust endothelial tube formation compared to 2D-EXOs-iMECs. The PAM@GO-EXOs-iMECs were subsequently encapsulated within a methoxy polyethylene glycol (MPEG) hydrogel to form a sustained-release bioactive dressing (PAM@GO-EXOs-MPEG). In murine burn models, PAM@GO-EXOs-MPEG accelerated wound closure, improved collagen alignment, and fostered neovascularization compared to 2D-EXOs-iMECs. Meanwhile, proteomic profiling revealed profound enrichment of proteins linked to epidermal development, cytoskeletal reorganization, and inflammatory resolution following treatment with PAM@GO-EXOs-MPEG. Collectively, this work establishes an innovative PAM@GO scalable platform for significantly promoting exosome production and introduces a clinically translatable exosome-hydrogel hybrid with substantial regenerative potential for severe burn repair.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e05468"},"PeriodicalIF":9.6,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microencapsulated Glass Ionomer Cement-Driven Dental Self-Healing Resin Composites With Enhanced Mechanical Strength, Biocompatibility, and Reparative Dentin Formation.","authors":"Yanyan Han, Junjun Wang, Dan Lin, Jiali Wang, Qinyan Zhu, Yizhang Yang, Yuqing Chen, Meifang Zhu, Ruili Wang, Yaqin Zhu","doi":"10.1002/adhm.202505543","DOIUrl":"https://doi.org/10.1002/adhm.202505543","url":null,"abstract":"<p><p>Long-term applications of dental resin composites are restricted by their limited service lives due to microcrack-induced fractures, while existing self-healing systems face challenges including insufficient biocompatibility and a lack of standardized evaluation. A self-healing resin composite incorporating glass ionomer cement-based silica microcapsules (GIC-SiO₂ MCs) was developed with controlled particle size covering macro- and micro-fillers via optimized synthetic parameters. Microcracks ruptured MCs, releasing healing liquid that reacted with powder in the resin matrix to form crack-sealing GIC. An optimal MCs ratio of 10wt% significantly improved hydrophilicity, flexural strength (from 58.6 to 87.8 MPa, reaching ISO standard), and cytocompatibility. A systematic methodology of self-healing efficiency evaluation was established, integrating morphological and mechanical restoration. The 10 wt.% MC-filled resin showed superior scratch closure in area and depth, recovery of fracture toughness (256.6%), and the highest comprehensive healing efficiency (161.2%). In a rat model, the 10 wt.% MC-incorporated resin elicited mild inflammatory responses and significantly enhanced reparative dentin formation, previously unreported in resin-based material. The developed self-healing resin composite combined enhanced mechanical properties, autonomous self-healing, anti-caries activity, and bioactivity for remineralization and reparative dentin formation. This work offered a pioneering strategy and evaluative foundation for developing clinically applicable self-healing dental materials, bridging the gap between experimental innovation and clinical practice.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e05543"},"PeriodicalIF":9.6,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147830972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-Printhead Parallel Printing of Polycaprolactone Barrier/Filler-Integrated Scaffolds for Alveolar Bone Repair.","authors":"Zijie Meng, Na Li, Jianzhen She, Le Wang, Yabo Zhang, Yanwen Su, Kaixin Shi, Bolei Cai, Dichen Li, Liang Kong, Jiankang He","doi":"10.1002/adhm.202505588","DOIUrl":"https://doi.org/10.1002/adhm.202505588","url":null,"abstract":"<p><p>Most current guided bone regeneration (GBR) procedures rely on manual assembly of membranes and filler materials during surgery, which often results in reduced shape fidelity, potential loss or displacement of graft powder, decreased operational efficiency and consistency. Here, we propose a multi-printhead parallel printing strategy for the fabrication of barrier/filler-integrated GBR scaffolds for alveolar bone repair by upgrading a conventional melt extrusion-based printing system with a parallelized 10-printhead module. Compared with conventional single-printhead system, the parallel 10-printhead configuration introduces thermal crosstalk, elevating local temperatures near the building platform and hindering the proper solidification of printed structures. By implementing cooling convection via fans and temperature compensation, we achieved simultaneous printing of 10 thin-wall membrane structures with consistent geometry and interlayer-bonding strength. Moreover, the system enables parallel printing of triply periodic minimal surface (TPMS) porous structures and barrier/filler-integrated GBR scaffolds, substantially enhancing overall manufacturing efficiency. In vivo studies using a rabbit alveolar defect model further demonstrated that the parallel-printed integrated scaffolds effectively prevented soft tissue invasion while promoting robust bone regeneration, achieving outcomes superior to those of clinically established GBR strategies. The proposed multi-printhead parallel printing technique offers a scalable, efficient way to mass-produce clinically applicable polymeric implants.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e05588"},"PeriodicalIF":9.6,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fully Wireless and Flexible Valves for Multiplexed and Prolonged Intravesical Liquid Release.","authors":"Boyang Xiao, Yi Zhu, Yusheng Wang, Janene M Pierce, Jeffrey J Tosoian, Xiaoguang Dong","doi":"10.1002/adhm.71197","DOIUrl":"https://doi.org/10.1002/adhm.71197","url":null,"abstract":"<p><p>Minimally invasive, long-term, and precisely controlled drug delivery is essential for treating bladder diseases such as interstitial cystitis and bladder cancer. However, conventional approaches, including injection-based delivery and indwelling catheters, offer limited controllability, cause patient discomfort, and increase the risk of infection and tissue irritation. Existing intravesical devices further lack active control over drug release, are restricted to single therapeutic agents, and may induce bladder overactivity due to continuous mechanical stimulation. Here, we present a strategy to remotely control multiple flexible magnetic valves on a soft robotic patch for controlled, multiplexed, and sustained liquid delivery. The device integrates magnetic valves with soft osmotic pumps to achieve precise dosing, selective release, and on-demand mixing of multiple therapeutics. Release rates are tuned by modulating valve duty cycles, while coordinated multi-valve actuation enables independent ejection and programmable mixing. A bioadhesive soft patch provides stable attachment to wet bladder tissue for over seven days. Wireless, selective valve control is achieved using a portable magnetic actuation system with wireless sensing feedback. Phantom and ex vivo porcine bladder studies demonstrate robust adhesion, controlled multiplexed delivery, and long-term operational stability. This platform establishes a foundation for minimally invasive and on-demand intravesical therapy for precision medicine.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71197"},"PeriodicalIF":9.6,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Biomimetic Palpation Platform for the Quantitative and Non-Invasive Assessment of Tissue Compliance.","authors":"Joongmi Kim, Yu-Jin Lee, Myoung-Ock Cho, Seunghwan Seo, Kyoung-Yong Chun, Chang-Soo Han","doi":"10.1002/adhm.71212","DOIUrl":"https://doi.org/10.1002/adhm.71212","url":null,"abstract":"<p><p>Physiological palpation serves as a primary clinical modality for identifying pathological changes in tissue compliance. However, its diagnostic precision is inherently limited by the subjective nature of human haptic perception and the lack of quantifiable mechanical metrics. This work describes a bio-inspired, portable tactile interface engineered for the non-invasive and real-time characterization of tissue stiffness. The system incorporates multimodal piezoresistive sensing elements that emulate the specific mechanotransduction functions of cutaneous receptors, namely Merkel disks and Ruffini endings. By integrating Hertzian contact mechanics to decouple pressure and strain signals, the platform analytically derives the effective Young's modulus of heterogeneous soft tissues. The developed sensor architecture exhibits a functional range of 0-600 kPa and a gauge factor of 10.8, facilitating high-fidelity detection of subcutaneous anomalies. Validation against various nodule geometries and depths demonstrates that the system achieves a diagnostic resolution surpassing conventional manual assessments. Furthermore, the integration of wireless data processing enables instantaneous, on-site mechanical profiling. This platform provides a scalable framework for objective diagnostics, robotic haptics, and continuous physiological monitoring, establishing a robust bridge between qualitative clinical observation and quantitative biomechanical analysis.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71212"},"PeriodicalIF":9.6,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147830916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}