Advanced Healthcare Materials最新文献

Immunosuppressive Formulations for Immunological Defense against Traumatic Brain Injury. 创伤性脑损伤免疫防御的免疫抑制制剂。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-05-29 DOI: 10.1002/adhm.202501417

Kelly Lintecum, Abhirami Thumsi, Kara Dunn, Lindsey Druschel, Sierra Chimene, David Flores Prieto, Amberlyn Simmons, Shivani Mantri, Arezoo Esrafili, Srivatsan J Swaminathan, Mytreyi Trivedi, Shreya Anandan, Crystal Willingham, Alondra Davila, Sahil Inamdar, Joslyn L Mangal, Abhirami P Suresh, Niveda M Kasthuri, Madan Mohan Chandra Sekhar Jaggarapu, Nicole Appel, Taravat Khodaei, Nathan D Ng, Alison Sundem, Sanmoy Pathak, George Bjorklund, Jason Newbern, Jeffrey Capadona, Sarah E Stabenfeldt, Abhinav P Acharya

{"title":"Immunosuppressive Formulations for Immunological Defense against Traumatic Brain Injury.","authors":"Kelly Lintecum, Abhirami Thumsi, Kara Dunn, Lindsey Druschel, Sierra Chimene, David Flores Prieto, Amberlyn Simmons, Shivani Mantri, Arezoo Esrafili, Srivatsan J Swaminathan, Mytreyi Trivedi, Shreya Anandan, Crystal Willingham, Alondra Davila, Sahil Inamdar, Joslyn L Mangal, Abhirami P Suresh, Niveda M Kasthuri, Madan Mohan Chandra Sekhar Jaggarapu, Nicole Appel, Taravat Khodaei, Nathan D Ng, Alison Sundem, Sanmoy Pathak, George Bjorklund, Jason Newbern, Jeffrey Capadona, Sarah E Stabenfeldt, Abhinav P Acharya","doi":"10.1002/adhm.202501417","DOIUrl":"https://doi.org/10.1002/adhm.202501417","url":null,"abstract":"Traumatic brain injury (TBI) and subsequent neurodegeneration is partially driven by chronic inflammation both locally and systemically. Yet, current clinical intervention strategies do not mitigate inflammation sequelae necessitating the development of innovative approaches to reduce inflammation and minimize deleterious effects of TBI. Herein, a subcutaneous formulation based on polymer of alpha-ketoglutarate (paKG) delivering glycolytic inhibitor PFK15 (PFKFB3 inhibitor, a rate limiting step in glycolysis), alpha-ketoglutarate (to fuel Krebs cycle) and peptide antigen from myelin proteolipid protein (PLP139-151) is utilized as the prophylactic immunosuppressive formulation in a mouse model of TBI. In vitro, the paKG(PFK15+PLP) formulation stimulates proliferation of immunosuppressive regulatory T cells and induces generation of T helper-2 cells. When given subcutaneously in the periphery two weeks prior to mice sustaining a TBI, the formulation increases frequency of immunosuppressive macrophages and dendritic cells (DCs) in the periphery and the brain at day 7 post-TBI and by 28 days post-TBI enhanced PLP-specific immunosuppressive cells infiltrate the brain. Immunohistology measurements of neuroinflammation are altered 28 days post-TBI, spatial proteomics reveals evidence of enhanced autophagy in the injury penumbra, and the active formulation improves motor function. Overall, these data suggest that the TBI immunosuppressive formulation successfully induces an anti-inflammatory profile and decreases TBI-associated inflammation.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2501417"},"PeriodicalIF":10.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing Nanohybridized Niclosamide for Precision Mpox Therapeutics (Adv. Healthcare Mater. 14/2025) 利用纳米杂交奈洛沙胺用于精确Mpox治疗（Adv. Healthcare Mater. 14/2025）

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-05-28 DOI: 10.1002/adhm.202570086

N. Sanoj Rejinold, Geun-woo Jin, Jin-Ho Choy

引用次数: 0

3D Microtumors Representing Ovarian Cancer Minimal Residual Disease Respond to the Fatty Acid Oxidation Inhibitor Perhexiline (Adv. Healthcare Mater. 14/2025) 代表卵巢癌微小残留病的3D微肿瘤对脂肪酸氧化抑制剂过己胺的反应（Adv. Healthcare Mater. 14/2025）

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-05-28 DOI: 10.1002/adhm.202570082

Xingyun Yang, Mara Artibani, Yongcheng Jin, Aneesh Aggarwal, Yujia Zhang, Sandra Muñoz-Galvan, Ellina Mikhailova, Lena Rai, Nobina Mukherjee, Ravinash Krishna Kumar, Ashwag Albukhari, Shaohua Ma, Linna Zhou, Ahmed Ashour Ahmed, Hagan Bayley

引用次数: 0

Controlled Self-Destructive Engineered Bacteria for Effective Immuno-Photodynamic Therapy Against Melanoma. 控制自毁工程细菌对黑色素瘤有效的免疫光动力治疗。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-05-28 DOI: 10.1002/adhm.202405210

Xinting Xu, Ying Zhang, Ye Tian, Lan Guo, Lizhi Zhou, Yiqun Wan, Ziqi Fang, Fangyan Ouyang, Hao Wan

{"title":"Controlled Self-Destructive Engineered Bacteria for Effective Immuno-Photodynamic Therapy Against Melanoma.","authors":"Xinting Xu, Ying Zhang, Ye Tian, Lan Guo, Lizhi Zhou, Yiqun Wan, Ziqi Fang, Fangyan Ouyang, Hao Wan","doi":"10.1002/adhm.202405210","DOIUrl":"https://doi.org/10.1002/adhm.202405210","url":null,"abstract":"The super aggressive and metastasizing nature of melanoma urgently calls for effective therapeutic scenarios. Recent advances in biohybrids comprising bacteria and chemical substances have demonstrated significant merits in treating cancer by attribute complementation. Here, through bioorthogonal chemistry, the developed photosensitizer (IN) is covalently anchored onto the surface of an attenuated Salmonella typhimurium strain (VNP) engineered with the programmed cell death protein 1 (PD-1)-encoding plasmid, creating controlled self-destructive engineered bacteria (VNP-mPD-1@IN). After intravenous injection into B16F10 melanoma-bearing mice, VNP-mPD-1@IN specifically accumulates within the tumor mediated by the hypoxic tropism of VNP, encoding PD-1 within tumor cells and simultaneously triggering partial tumor cell apoptosis due to the self-cytotoxicity of VNP. Once excited by long-wavelength photons, IN on VNP-mPD-1@IN efficiently generates reactive oxygen species, which not only induces the apoptosis of tumor cells, but also triggers bacterial self-destruction to eliminate potential biosafety concerns. The apoptosis of tumor cells leads to considerable immunogenic cell death to reprogram immune environment, which is powered by PD-1-mediated immune checkpoint blockage. As a result, effective immuno-photodynamic therapy is realized to suppress the growth of primary and distant B16F10 tumors as well as prevent their metastasis. This study sheds light on the remolding of bacteria for effective cancer therapy.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2405210"},"PeriodicalIF":10.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial-Constraint Modulation of Intra/Extracellular Reactive Oxygen Species by Adaptive Hybrid Materials for Boosting Pyroptosis and Combined Immunotherapy of Breast Tumor. 自适应杂化材料对细胞内/细胞外活性氧的空间约束调节促进乳腺肿瘤的焦亡和联合免疫治疗。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-05-28 DOI: 10.1002/adhm.202500371

Luoli Zhou, Sheng Zhao, Yijing Xu, Lin Li, Yunyun Wu, Jing Zhu, Daqing Xia, Fan Li, Kaiyong Cai, Jixi Zhang

{"title":"Spatial-Constraint Modulation of Intra/Extracellular Reactive Oxygen Species by Adaptive Hybrid Materials for Boosting Pyroptosis and Combined Immunotherapy of Breast Tumor.","authors":"Luoli Zhou, Sheng Zhao, Yijing Xu, Lin Li, Yunyun Wu, Jing Zhu, Daqing Xia, Fan Li, Kaiyong Cai, Jixi Zhang","doi":"10.1002/adhm.202500371","DOIUrl":"https://doi.org/10.1002/adhm.202500371","url":null,"abstract":"Pyroptosis-immunotherapy has potential for triple-negative breast cancer treatment, but its efficacy is limited by insufficient pyroptosis activation and the need for phased, balanced, and spatially controlled activation of active species during long-term treatment. To reconcile intracellular/extracellular demands in tumor ablation, a nanoparticle-hydrogel hybrid enabling spatiotemporal reactive oxygen species (ROS) modulation is engineered. An open-shell sonosensitizer with unpaired electrons in its molecular orbitals is prepared by chelating Cu2⁺ with TCPP. These sonosensitizers are undergoing bovine serum albumin mediated biomineralization to form calcium phosphate particles and are incorporated into an injectable hydrogel through Schiff base crosslinking between dopamine-functionalized oxidized hyaluronic acid and gallic acid-modified chitosan. After intratumoral injection, nanoparticles endocytosed into tumor cells undergo acidic degradation, releasing calcium ions and GSH-activatable sonosensitizers. Calcium overload synergizes with ultrasound-mediated oxidative stress to induce mitochondrial damage and pyroptosis, while adhesive hydrogels retained in the extracellular matrix control excessive secondary ROS levels to protect oxidation-sensitive entities. This dual-action mechanism enhances the overall therapeutic effect by combining immediate tumor killing with long-term immune activation. This study provides a new route to hybrid material design, addressing the conflicting demands of short-term tumor ablation and long-term immune activation, overcoming the limitations of current pyroptosis-based immunotherapies.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2500371"},"PeriodicalIF":10.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fibrosis Drug Efficacy Assessment Based on Microfluidic Mechanical Property Evaluation of Spheroid Models (Adv. Healthcare Mater. 14/2025) 基于球体模型微流控力学性能评价的纤维化药物疗效评估（adh . Healthcare Mater. 14/2025）

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-05-28 DOI: 10.1002/adhm.202570085

Bolam Kim, Jeong Yeon Kim, Hye Won Kim, In Yeong Cho, Ki Wan Bong

引用次数: 0

Tailoring Lipid Nanoparticle with Ex Situ Incorporated Conjugated Oligoelectrolyte for Enhanced mRNA Delivery Efficiency (Adv. Healthcare Mater. 14/2025) 裁剪脂质纳米颗粒与非原位结合的共轭低聚电解质，以提高mRNA的传递效率（Adv. Healthcare Mater. 14/2025）

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-05-28 DOI: 10.1002/adhm.202570087

Wilson Wee Mia Soh, Esteban Finol, Samuel J. W. Chan, Ji-Yu Zhu, Sebastian Sean Jing Kang Liau, Ava Bier, Eng Eong Ooi, Guillermo C. Bazan

引用次数: 0

Issue Information: Adv. Healthcare Mater. 14/2025 发布信息：Adv. Healthcare Mater. 14/2025

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-05-28 DOI: 10.1002/adhm.202570084

引用次数: 0

EGR1-Driven Re-Epithelialization Enabled by Rutin-Based Self-Assembled Hydrogel Platform for Oral Ulcer Therapy. 芦丁自组装水凝胶平台实现egr1驱动的再上皮化治疗口腔溃疡。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-05-28 DOI: 10.1002/adhm.202500996

Bin Zhao, Xinjie Qiu, Chong Wang, Shaobang Wu, Xin Yin, Lina Zhang, Xuedan Yan, Shuqi Sun, Xinyue Zeng, Xiuyun Ren

{"title":"EGR1-Driven Re-Epithelialization Enabled by Rutin-Based Self-Assembled Hydrogel Platform for Oral Ulcer Therapy.","authors":"Bin Zhao, Xinjie Qiu, Chong Wang, Shaobang Wu, Xin Yin, Lina Zhang, Xuedan Yan, Shuqi Sun, Xinyue Zeng, Xiuyun Ren","doi":"10.1002/adhm.202500996","DOIUrl":"https://doi.org/10.1002/adhm.202500996","url":null,"abstract":"Oral ulcer (OU) is a highly prevalent mucosal disease characterized by persistent epithelial disruption. The primary challenge in its prolonged healing process is the disorder of re-epithelialization. This study develops a self-assembled hydrogel platform based on the natural small molecule rutin, which overcomes the re-epithelialization barrier through the synergistic effects of early growth response factor 1 (EGR1) gene programming and microenvironment remodeling. In this hydrogel, rutin formed supramolecular structures via hydrogen bonds and π-π interactions without structural modification. In vitro experiments confirm that rutin-based self-assembled hydrogel (RUTG) possesses excellent sustained-release properties and biocompatibility. Moreover, RUTG specifically regulates the transcriptional activation and translation of EGR1, thereby mediating the expression of re-epithelialization-related protein SOX9, and ultimately accelerating cell proliferation and migration as well as promoting re-epithelialization. Additionally, RUTG demonstrates beneficial anti-inflammatory and antioxidant properties, effectively remodeling the local microenvironment. In vivo studies using an oral ulcer model further confirm that RUTG could significantly accelerate the re-epithelialization process, shorten the ulcer healing cycle, and achieve functional tissue reconstruction. Collectively, this carrier-free hydrogel system, which integrates gene programming with microenvironment modulation to achieve efficient re-epithelialization, holds promise for introducing novel approaches to the treatment of oral ulcers.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2500996"},"PeriodicalIF":10.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Motor-Free Soft Robots for Cancer Detection, Surgery, and In Situ Bioprinting (Adv. Healthcare Mater. 14/2025) 用于癌症检测、手术和原位生物打印的无电机软机器人（ad . Healthcare Mater. 14/2025）

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-05-28 DOI: 10.1002/adhm.202570083

Chi Cong Nguyen, James Davies, Aditya Ashok, Trung Thien Hoang, Anahid Ehteda, Tran Bach Dang, Emanuele Nicotra, Hien A. Tran, Bibhu Sharma, Kefan Zhu, Phuoc Thien Phan, Adrienne Ji, Jingjing Wan, Jelena Rnjak-Kovacina, Orazio Vittorio, Hoang-Phuong Phan, Nigel Hamilton Lovell, Thanh Nho Do

{"title":"Motor-Free Soft Robots for Cancer Detection, Surgery, and In Situ Bioprinting (Adv. Healthcare Mater. 14/2025)","authors":"Chi Cong Nguyen, James Davies, Aditya Ashok, Trung Thien Hoang, Anahid Ehteda, Tran Bach Dang, Emanuele Nicotra, Hien A. Tran, Bibhu Sharma, Kefan Zhu, Phuoc Thien Phan, Adrienne Ji, Jingjing Wan, Jelena Rnjak-Kovacina, Orazio Vittorio, Hoang-Phuong Phan, Nigel Hamilton Lovell, Thanh Nho Do","doi":"10.1002/adhm.202570083","DOIUrl":"https://doi.org/10.1002/adhm.202570083","url":null,"abstract":"Teleoperated Surgical Robotic SystemsIn article number 2404623, Thanh Nho Do and co-workers introduce a motor-free soft robotic platform designed for cancer detection, microsurgery, and in-situ 3D bioprinting for wound healing in minimally invasive delivery. This system leverages soft fibrous syringe architectures (SFSA) to achieve miniaturization, enhanced flexibility, and precise motion control. Additionally, it integrates micro-bioelectronics for electrochemical impedance measurements and radio-frequency ablation, enabling advanced diagnostic and therapeutic capabilities.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture>\u0000 </div>\u0000 </figure>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"14 14","pages":""},"PeriodicalIF":10.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.202570083","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0