Advanced Healthcare Materials最新文献_第2页

Chemical Strategies for Multistimuli Responsive Dynamic Covalent Materials in Regenerative Medicine 再生医学中多刺激反应动态共价材料的化学策略。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-10-16 Epub Date: 2026-09-17 DOI: 10.1002/adhm.71721

Saurabh Joshi, Matthew B. Baker, Dominik Schauenburg

{"title":"Chemical Strategies for Multistimuli Responsive Dynamic Covalent Materials in Regenerative Medicine","authors":"Saurabh Joshi, Matthew B. Baker, Dominik Schauenburg","doi":"10.1002/adhm.71721","DOIUrl":"10.1002/adhm.71721","url":null,"abstract":"<p>Regenerative medicine requires biomaterials that can function within complex and dynamically changing biological environments. Dynamic covalent chemistry provides a compelling foundation for such materials by combining covalent stability with reversible bond exchange, enabling adaptability, self-healing, and stimulus-responsive behavior. Dynamic covalent biomaterials have therefore emerged as promising platforms for tissue scaffolds, wound healing, and controlled delivery applications. Although many existing systems respond to a single stimulus, such as pH, redox conditions, or enzymatic activity, biological environments are inherently multiresponsive, integrating mechanical, chemical, and biochemical cues simultaneously. As a result, single-stimulus dynamic materials often fail to achieve predictable performance in vivo. This review focuses on chemical strategies for engineering multistimuli responsive dynamic covalent materials that more closely reflect the complexity of native regenerative processes. We discuss key reversible covalent motifs, their thermodynamic and kinetic characteristics, and how these can be combined through orthogonal chemistries, multicomponent networks, and hierarchical architectures to achieve tunable mechanics, stress relaxation, degradation, and biofunctionality. Finally, we outline current challenges and opportunities, emphasizing the need for expanded biocompatible chemistries and rational design principles to advance multistimuli responsive dynamic covalent materials toward translational regenerative medicine.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 38","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.71721","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148987194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondria-Targeted Nanozyme Reprograms Dendritic-Cell Immunometabolism via Microenvironment-Responsive CO Release to Treat Periodontitis 线粒体靶向纳米酶通过微环境响应性CO释放重编程树突细胞免疫代谢治疗牙周炎。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-10-16 Epub Date: 2026-09-18 DOI: 10.1002/adhm.71727

Shangyan Shan, Chengyu Liu, Lina Ding, Weishu Zeng, Haoran Cui, Jia Liu, Meiqi Li, Xu Ding, Biao Dong, Liang Cheng, Manlin Qi, Lin Wang

{"title":"Mitochondria-Targeted Nanozyme Reprograms Dendritic-Cell Immunometabolism via Microenvironment-Responsive CO Release to Treat Periodontitis","authors":"Shangyan Shan, Chengyu Liu, Lina Ding, Weishu Zeng, Haoran Cui, Jia Liu, Meiqi Li, Xu Ding, Biao Dong, Liang Cheng, Manlin Qi, Lin Wang","doi":"10.1002/adhm.71727","DOIUrl":"10.1002/adhm.71727","url":null,"abstract":"<div>\u0000 \u0000 <p>Inflammatory diseases are characterized by overactivated immune responses and a disrupted metabolic equilibrium, particularly in dendritic cells (DCs), where mitochondrial reactive oxygen species (mtROS) burst and metabolic reprogramming drives pathological maturation. While modulating immunometabolism is a promising therapeutic avenue, achieving subcellular-targeted delivery of bioactive molecules remains a formidable challenge. Here, we report a mitochondria-targeted nanozyme designed to concurrently scavenge mtROS and reprogram DC metabolism for effective anti-inflammatory therapy in periodontitis. This system is constructed based on Prussian blue nanoparticles (PB NPs) loaded with manganese carbonyl, a high oxidative stress-responsive carbon monoxide (CO) donor, and further modified with triphenylphosphine for mitochondrial targeting. This nanozyme efficiently accumulates in the mitochondria of activated DCs, where it efficiently scavenges mtROS and concurrently delivers controlled CO release, synergistically modulating DC function. Metabolomics analysis reveals that CO suppresses DC maturation by reprogramming cellular metabolism, including inhibiting the tricarboxylic acid cycle, modulating glycolysis, and disrupting fatty acid synthesis. Consequently, the synergistic action of PB NPs and CO effectively reverses the pro-inflammatory phenotype of DCs, reshapes the immune microenvironment, and ultimately alleviates periodontal inflammation in vivo. This work presents a promising strategy for curing inflammatory diseases by targeting metabolic reprogramming at the subcellular level.</p>\u0000 </div>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 38","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149000923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conjugated Porphyrin Polymer With Superior Charge Transfer for Photodynamic-Immunomodulatory Prevention of CIED Infection in Diabetes 具有优越电荷转移的共轭卟啉聚合物光动力免疫调节预防糖尿病患者CIED感染。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-10-16 Epub Date: 2026-07-28 DOI: 10.1002/adhm.71482

Honghao Ma, Jinguo Xu, Rongrong Gu, Chuanhui Dong, Te Chen, Yi Mu, Jing Zhu, Yating Wang, Wen Wang, Yingying Zhang, Hongyu Ma, Xiaochen Wang, Sheng Ye, Cheng Cheng

{"title":"Conjugated Porphyrin Polymer With Superior Charge Transfer for Photodynamic-Immunomodulatory Prevention of CIED Infection in Diabetes","authors":"Honghao Ma, Jinguo Xu, Rongrong Gu, Chuanhui Dong, Te Chen, Yi Mu, Jing Zhu, Yating Wang, Wen Wang, Yingying Zhang, Hongyu Ma, Xiaochen Wang, Sheng Ye, Cheng Cheng","doi":"10.1002/adhm.71482","DOIUrl":"10.1002/adhm.71482","url":null,"abstract":"<p>Diabetic patients face heightened risks for cardiac implantable electronic devices (CIED) infections. Herein, we developed a near-infrared (NIR)-activated porphyrin polymer (PTCPP) for photodynamic therapy of CIED infections, which achieves a 100% antibacterial rate with a 22% increase in anti-biofilm efficacy compared to porphyrin (TCPP) in vitro. In diabetic rats, a 93% bactericidal rate is further demonstrated by PTCPP, along with a 97% reduction in the levels of pro-inflammatory factors. It is found that singlet oxygen (<sup>1</sup>O<sub>2</sub>) and hydroxyl radicals (•OH) are the main reactive oxygen species (ROS), which can eliminate methicillin-resistant <i>Staphylococcus aureus</i> by disrupting mature biofilms. The immunomodulatory effect of PTCPP stems from dynamic regulation of macrophage polarization. Under irradiation, ROS induce M1 activation to eliminate pathogens, followed by metabolic reprogramming that promotes healing-conducive M2 polarization, thereby accelerating tissue repair. This work showcases the great potential of synergistic photodynamic-immunomodulatory strategies for the next-generation prevention of complex implant-related infections.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 38","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.71482","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148596716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood–Brain Barrier Regulation: Evolving From Classic Strategies to Electrochemical Ion and Reactive Oxygen Species Control 血脑屏障调节：从经典策略到电化学离子和活性氧控制的演变。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-10-16 Epub Date: 2026-09-06 DOI: 10.1002/adhm.71685

Xiaokang Hu, Caiyu Liu, Meijun Pang, Zhiyuan Shi, Dong Ming, Xiuyun Liu

{"title":"Blood–Brain Barrier Regulation: Evolving From Classic Strategies to Electrochemical Ion and Reactive Oxygen Species Control","authors":"Xiaokang Hu, Caiyu Liu, Meijun Pang, Zhiyuan Shi, Dong Ming, Xiuyun Liu","doi":"10.1002/adhm.71685","DOIUrl":"10.1002/adhm.71685","url":null,"abstract":"<p>The blood–brain barrier (BBB), while indispensable for maintaining central nervous system (CNS) homeostasis, constitutes the principal impediment to effective therapeutic delivery for neurodegenerative disorders, particularly hindering spatially resolved modulation of extracellular ions and reactive oxygen species (ROS) within the neural microenvironment. Contemporary electrochemical methodologies have emerged as a paradigm shift for dynamically reconciling these dual parameters, thereby enabling targeted neuroregulation. Critical review of this field reveals a distinct evolution from passive physiological interventions to active electrochemical engineering approaches. Current research, however, encounters persistent translational barriers including insufficient spatiotemporal resolution in neural interfaces, incomplete mechanistic understanding of ROS-ionic crosstalk, and scalability limitations of nanoscale delivery systems. To transcend these limitations, the synergistic convergence of electrochemical platforms with machine learning (ML)–guided predictive analytics, near-infrared (NIR) phototherapy, and biocompatible nanocarrier-mediated delivery systems constitutes a strategic imperative in next-generation neurotherapeutic development. Such interdisciplinary convergence is not merely incremental but rather a fundamental prerequisite for realizing clinically translatable neural microenvironment modulation.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 38","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.71685","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148899738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conjugated Porphyrin Polymer With Superior Charge Transfer for Photodynamic-Immunomodulatory Prevention of CIED Infection in Diabetes (Adv. Healthcare Mater. 38/2026) 具有优越电荷转移的共轭卟啉聚合物在光动力免疫调节预防糖尿病CIED感染中的应用[j] .中华医学杂志。38/2026。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-10-16 DOI: 10.1002/adhm.71678

Honghao Ma, Jinguo Xu, Rongrong Gu, Chuanhui Dong, Te Chen, Yi Mu, Jing Zhu, Yating Wang, Wen Wang, Yingying Zhang, Hongyu Ma, Xiaochen Wang, Sheng Ye, Cheng Cheng

{"title":"Conjugated Porphyrin Polymer With Superior Charge Transfer for Photodynamic-Immunomodulatory Prevention of CIED Infection in Diabetes (Adv. Healthcare Mater. 38/2026)","authors":"Honghao Ma, Jinguo Xu, Rongrong Gu, Chuanhui Dong, Te Chen, Yi Mu, Jing Zhu, Yating Wang, Wen Wang, Yingying Zhang, Hongyu Ma, Xiaochen Wang, Sheng Ye, Cheng Cheng","doi":"10.1002/adhm.71678","DOIUrl":"https://doi.org/10.1002/adhm.71678","url":null,"abstract":"<p><b>Photodynamic Immunomodulation</b></p><p>The cover illustrates a self-assembled porphyrin polymer (PTCPP) activated by near-infrared light to eradicate drug-resistant bacterial biofilms on cardiac implants. Simultaneously, PTCPP dynamically regulates macrophage polarization through immunometabolic modulation, promoting inflammation resolution and tissue regeneration. This dual antibacterial-immunomodulatory strategy provides a promising approach for preventing diabetic cardiac implant-associated infections. More details can be found in the Research Article by Jing Zhu, Xiaochen Wang, Sheng Ye, Cheng Cheng, and co-workers (DOI: 10.1002/adhm.71482).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 38","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.71678","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149205960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "A Mechanically Adaptive Titanium Scaffold with a Lattice-Modulated Piezocatalytic Coating for Infection Treatment and Bone Regeneration". 修正“用于感染治疗和骨再生的具有晶格调制压电涂层的机械适应性钛支架”。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-10-16 DOI: 10.1002/adhm.71850

引用次数: 0

Issue Information: Adv. Healthcare Mater. 38/2026 发行信息：广告医疗保健Mater. 38/2026

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-10-16 DOI: 10.1002/adhm.71681

引用次数: 0

An Injectable Low-Swelling and Mechanically Robust Bioadhesive Sealant for Sutureless Watertight Dural Repair 一种可注射的低肿胀、机械坚固的生物胶粘剂，用于无缝合线的硬脑膜水密修复。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-10-16 Epub Date: 2026-09-07 DOI: 10.1002/adhm.71696

Qi Wang, Gang He, Yiwen Xian, Zheng Pan, Qiqi Huang, Chong Zhang, Decheng Wu

{"title":"An Injectable Low-Swelling and Mechanically Robust Bioadhesive Sealant for Sutureless Watertight Dural Repair","authors":"Qi Wang, Gang He, Yiwen Xian, Zheng Pan, Qiqi Huang, Chong Zhang, Decheng Wu","doi":"10.1002/adhm.71696","DOIUrl":"10.1002/adhm.71696","url":null,"abstract":"<div>\u0000 \u0000 <p>Watertight dural closure is essential for successful cranial and spinal surgery but remains a major clinical challenge due to persistent cerebrospinal fluid (CSF) leakage and associated complications. Conventional dural suturing is particularly challenging in cases involving fragile dura or anatomically complex defects, while existing sealants often suffer from delayed gelation, inadequate wet-tissue adhesion, and excessive swelling that may cause neural tissue compression. Herein, we report an injectable, biocompatible, low-swelling bioadhesive sealant (DLSS) based on <i>N</i>-hydroxysuccinimide-activated tetra-armed poly(ethylene glycol) and amine-functionalized gelatin for sutureless dural repair. The optimized hydrogel exhibits rapid in situ gelation, robust mechanical properties, effective wet-tissue adhesion, high burst pressure resistance, and limited swelling (13.2% volumetric swelling ratio in artificial CSF). Furthermore, DLSS demonstrates cytocompatibility and hemocompatibility, supports fibroblast migration, and undergoes controlled biodegradation. Ex vivo testing on rabbit dura demonstrated rapid and durable sutureless sealing of dural defects by DLSS. In vivo evaluation in rat cranial and spinal dural defect models demonstrated that DLSS enabled effective dural closure and tissue repair without detectable CSF leakage, showing improved performance compared with commercial fibrin glue. Its translational potential was validated in clinically relevant beagle models. Collectively, DLSS offers a promising strategy for sutureless dural repair.</p>\u0000 </div>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 38","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional Nanofiber Membrane With Directional Moisture Pumping, Rapid Cooling, and Antibacterial Activity for Intertrigo Wound Microclimate Regulation and Therapy 具有定向吸湿、快速冷却和抗菌活性的多功能纳米纤维膜用于三合一伤口的微气候调节和治疗。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-10-16 Epub Date: 2026-09-08 DOI: 10.1002/adhm.71701

Yonglong Li, Mingzhang Li, Haibin Li, Chunsheng Guan, Ruolin Cao, Hao Shen, Jiang Chang, Botao Song

{"title":"Multifunctional Nanofiber Membrane With Directional Moisture Pumping, Rapid Cooling, and Antibacterial Activity for Intertrigo Wound Microclimate Regulation and Therapy","authors":"Yonglong Li, Mingzhang Li, Haibin Li, Chunsheng Guan, Ruolin Cao, Hao Shen, Jiang Chang, Botao Song","doi":"10.1002/adhm.71701","DOIUrl":"10.1002/adhm.71701","url":null,"abstract":"<div>\u0000 \u0000 <p>Both exposed-surface exudative wounds (e.g., burns and infected wounds) and intertriginous exudative wounds (e.g., intertrigo wounds) are characterized by excessive exudation, localized hyperthermia, and pathogen infection, yet effective dressings that simultaneously regulate these micro environmental factors remain limited. Herein, a sandwich-structured nanofiber membrane is developed with upper and lower hydrophobic pumping/antimicrobial layers and a middle hydrophilic xylitol-loaded cooling layer. Benefiting from the hydrophobic-hydrophilic-hydrophobic architecture, liquid is rapidly pumped from both sides into the middle layer, where xylitol dissolution is activated to induce localized endothermic cooling. The cooling effect is xylitol-dependent, reaching a temperature reduction of 6.5 °C within 5 min. This cascaded moisture-thermal regulation capability is validated in rat dorsal wounds and human skinfolds, representing exposed-surface and intertriginous exudative wounds, respectively. Moreover, incorporation of Ag nanoparticles confers broad-spectrum antimicrobial activity against <i>S. aureus</i>, <i>E. coli</i>, and <i>C. albicans</i>. The membrane significantly accelerates infected wound healing through synergistic moisture-thermal microclimate regulation and antibacterial action. This work provides an integrated strategy for microclimate management in complex exudative wounds and offers a promising platform for improving wound healing outcomes.</p>\u0000 </div>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 38","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Profiling Inflammatory Pathogenesis and Therapy: Ratiometric Photoacoustic Imaging of Energy Metabolism Dynamics With Upconversion Nanoprobes 表征炎症的发病机制和治疗：能量代谢动力学的比例光声成像与上转换纳米探针。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-10-16 Epub Date: 2026-09-07 DOI: 10.1002/adhm.71697

Qin Zhang, Handi Deng, Chengkang Li, Yuhan Chen, Le Bao, Shengjie Xu, Juan Xu, Cheng Ma, Yi Zhou, Chenjie Zhu

{"title":"Profiling Inflammatory Pathogenesis and Therapy: Ratiometric Photoacoustic Imaging of Energy Metabolism Dynamics With Upconversion Nanoprobes","authors":"Qin Zhang, Handi Deng, Chengkang Li, Yuhan Chen, Le Bao, Shengjie Xu, Juan Xu, Cheng Ma, Yi Zhou, Chenjie Zhu","doi":"10.1002/adhm.71697","DOIUrl":"10.1002/adhm.71697","url":null,"abstract":"<div>\u0000 \u0000 <p>NAD(P)H is a critical redox cofactor in cellular energy metabolism, yet real-time monitoring of its spatiotemporal dynamics in pathological contexts remains challenging due to the limited penetration depth and resolution of conventional imaging modalities. In this study, we developed a dual-modal ratiometric imaging nanoprobe that enables precise photoacoustic (PA) and upconversion luminescence imaging of this energy metabolism substrates. The nanoprobe conjugates an NAD(P)H-responsive chromophore and an internal reference dye onto NIR-excited upconversion nanoparticles, enabling self-calibrated quantification through ratiometric UCL and mPAT signals. This design minimizes artifacts from nanoprobe distribution and environmental variations, enhancing spatiotemporal accuracy. The utility of the nanoprobe is demonstrated in multiple disease models: it visualizes metabolic reprogramming during macrophage M1 polarization, tracks aberrant NAD(P)H accumulation in drug-induced and acute liver injury (ALI), and monitors metabolic responses to NAC and 2-DG interventions. Furthermore, in a calorie restriction (CR) combined immunotherapy model, the nanoprobe reveals that the TLR7/8 agonist R848 and glycolytic inhibitor 2-DG synergistically suppress tumor growth by reprogramming tumor-associated macrophage metabolism. This work provides a robust imaging platform for tracking energy metabolism dynamics, offering insights into the interplay between metabolic pathways and inflammatory diseases for developing targeted therapies.</p>\u0000 </div>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 38","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0