Advanced Healthcare Materials最新文献_第2页

Activatable MRI-Trackable Spherical Nucleic Acids for Idebenone Delivery Against Cerebral Ischemia–Reperfusion Injury 可激活的核磁共振可追踪球形核酸对脑缺血再灌注损伤的递送。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-11-06 Epub Date: 2026-10-05 DOI: 10.1002/adhm.71802

Yan Wu, Qinwen Huang, Yiru Jiang, Jiafeng Li, Reyihanguli Wushouer, Chuan Zhang, Jun Zhang

{"title":"Activatable MRI-Trackable Spherical Nucleic Acids for Idebenone Delivery Against Cerebral Ischemia–Reperfusion Injury","authors":"Yan Wu, Qinwen Huang, Yiru Jiang, Jiafeng Li, Reyihanguli Wushouer, Chuan Zhang, Jun Zhang","doi":"10.1002/adhm.71802","DOIUrl":"10.1002/adhm.71802","url":null,"abstract":"<div>\u0000 \u0000 Cerebral ischemia–reperfusion injury (IRI) is a key driver of poor prognosis in ischemic stroke. Idebenone (IDBN) shows promise for mitigating IRI, but its efficacy is limited by poor brain accumulation. Moreover, IDBN cannot be visually tracked, making it difficult to confirm whether it reaches the ischemic brain and exerts therapeutic effects. Here, IDBN functionalized with a reactive oxygen species (ROS)-cleavable bond is grafted onto phosphorothioate-modified DNA strands and co-assembled with ultrasmall superparamagnetic iron oxide (USPIO) to form USPIO-IDBN-SNAs, where SNAs stands for spherical nucleic acids. Exploiting upregulated class A scavenger receptors, USPIO-IDBN-SNAs target the ischemic area without targeting modifications and increase local IDBN concentration. Hydrophobic IDBN inside the SNAs limits water access to USPIO clusters, suppressing their contrast-enhancing ability. Under oxidative stress, IDBN is rapidly released and exerts remarkable protection. This release allows USPIO clusters to re-establish contact with water, activating their contrast-enhancing ability on T2-weighted imaging. Collectively, USPIO-IDBN-SNAs provide significant neuroprotection against IRI and offer a magnetic resonance imaging (MRI)-visible platform to monitor IDBN release in the ischemic brain, presenting a promising theranostic approach for precise, trackable stroke therapy.\u0000 </div>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 41","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149101348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation-Driven Design of Antimicrobial Hydrogel Wound Patches 3D-Printed by Digital Light Processing: Mapping Polysaccharide and Nanoparticle Effects. 通过数字光处理3d打印的抗菌水凝胶伤口贴片的配方驱动设计：绘制多糖和纳米颗粒效应。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-11-06 DOI: 10.1002/adhm.71948

M A Shadab Siddiqui, Maidul Hasan, Mahlet Tsedalu Adane, Walid Hossain, Md Iftekhar Shams, Md Sanaul Rabbi, Ammar Alsheghri, Md Abdul Aziz, M Nasiruzzaman Shaikh, Fahad Alam

{"title":"Formulation-Driven Design of Antimicrobial Hydrogel Wound Patches 3D-Printed by Digital Light Processing: Mapping Polysaccharide and Nanoparticle Effects.","authors":"M A Shadab Siddiqui, Maidul Hasan, Mahlet Tsedalu Adane, Walid Hossain, Md Iftekhar Shams, Md Sanaul Rabbi, Ammar Alsheghri, Md Abdul Aziz, M Nasiruzzaman Shaikh, Fahad Alam","doi":"10.1002/adhm.71948","DOIUrl":"https://doi.org/10.1002/adhm.71948","url":null,"abstract":"Wound dressings must balance antimicrobial efficacy with the printability limits imposed by nanoparticle-mediated ultraviolet attenuation during digital light processing 3D printing. Here, we develop process-structure-property relationships for poly(ethylene glycol) diacrylate (PEGDA)-based hydrogel wound patches containing Ag/ZnO-derived antimicrobial phases and polysaccharide/cellulose modifiers (cellulose nanofibrils, chitosan, or alginate). Beer-Lambert analysis shows that nanoparticle loading reduces optical penetration depth at 405 nm to 1.04-1.28 mm, narrowing the usable curing margin so that radiant exposure exceeds the critical energy by only 4%-5%. Flory-Rehner analysis of swelling reveals formulation-dependent crosslink density: alginate lowers effective crosslink density by 45% vs. neat PEGDA and increases mesh size from 0.42 to 0.60 nm. This network loosening drives 1.5× variation in water vapor transmission rate (WVTR; 346-518 g·m- 2·day- 1) and a 7× range in wettability (11.5°-81.1°). Two-way factorial analysis identifies polysaccharide type as the dominant driver of swelling (87.5% of variance) and antimicrobial efficacy (>50%), while nanoparticle type controls contact angle (60.1%) and WVTR (76.9%). The Ag + chitosan formulation (S5) achieves 23-24 mm inhibition zones against Escherichia coli and Bacillus sp. via chitosan-facilitated Ag+ diffusion plus intrinsic contact-killing. Inductively coupled plasma optical emission spectroscopy confirms cumulative Ag+ release (32.7 mg·L- 1 over 14 days), while Zn2 + remains immobilized below detection.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149339907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rotor-Controlled Vibronic Coupling Enables Efficient Near-Infrared Phosphorescence in Iridium(III) Complexes for Enhanced Mitochondrial Photodynamic Therapy 转子控制的振动耦合使铱（III）配合物中有效的近红外磷光用于增强线粒体光动力治疗。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-11-06 Epub Date: 2026-10-07 DOI: 10.1002/adhm.71805

Wei He, Tianyu Li, Jianyu Zhang, Ziyu Cui, Gian Albert Alfani, Jiaqi Peng, Faizal Khan, Zheng Zhao, Zijie Qiu, Jianwei Sun, Jacky Wing Yip Lam, Ryan Tsz Kin Kwok, Parvej Alam, Ben Zhong Tang

{"title":"Rotor-Controlled Vibronic Coupling Enables Efficient Near-Infrared Phosphorescence in Iridium(III) Complexes for Enhanced Mitochondrial Photodynamic Therapy","authors":"Wei He, Tianyu Li, Jianyu Zhang, Ziyu Cui, Gian Albert Alfani, Jiaqi Peng, Faizal Khan, Zheng Zhao, Zijie Qiu, Jianwei Sun, Jacky Wing Yip Lam, Ryan Tsz Kin Kwok, Parvej Alam, Ben Zhong Tang","doi":"10.1002/adhm.71805","DOIUrl":"10.1002/adhm.71805","url":null,"abstract":"<div>\u0000 \u0000 Near-infrared (NIR) phosphorescent iridium(III) complexes hold immense promise for biomedical imaging and optoelectronics but suffer from poor quantum yields due to the energy gap law, which amplifies nonradiative decay through vibrational quenching at lower energies. We introduce a molecular rotor engineering strategy that systematically modulates excited-state dynamics by varying the placement of the rotor on chromophoric and ancillary ligands. Restricting rotational motion upon aggregation or in rigid PMMA matrices dramatically suppresses nonradiative pathways, boosting quantum yields from ∼4% in solution to 65% in 10 wt% PMMA films, with further enhancements in the solid state (12.5%) and aggregates (14.5%). Structural and computational analyses reveal that molecular rotors govern excited-state behavior through configuration interaction between metal-to-ligand charge transfer (3MLCT) and ligand-centered (3LC) states, enabling dynamic population redistribution that tunes radiative and nonradiative channels without requiring discrete state conversion. This aggregation-induced phosphorescence (AIP) mechanism circumvents traditional energy gap limitations. The resulting efficient NIR emission demonstrates selective mitochondrial targeting and potent photodynamic anticancer activity, with aggregation-enhanced quantum yields proving essential for effective 1O2 generation. This rotor engineering approach establishes a versatile design framework for high-performance NIR emitters across therapeutic, imaging, and optoelectronic applications.\u0000 </div>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 41","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tetrahedral Framework Nucleic Acid-Based Small RNA Delivery: Prospects and Challenges in Bone and Cartilage Regeneration 基于四面体框架核酸的小RNA递送：骨和软骨再生的前景和挑战。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-11-06 Epub Date: 2026-10-06 DOI: 10.1002/adhm.71812

Liwei Fu, Zhengang Ding, Jiang Wu, Zhichao Zhang, Zhixing Zhang, Chuanyang Long, Jianhao Wu, Xiang Sui, Yongping Cao, Shuyun Liu, Quanyi Guo

{"title":"Tetrahedral Framework Nucleic Acid-Based Small RNA Delivery: Prospects and Challenges in Bone and Cartilage Regeneration","authors":"Liwei Fu, Zhengang Ding, Jiang Wu, Zhichao Zhang, Zhixing Zhang, Chuanyang Long, Jianhao Wu, Xiang Sui, Yongping Cao, Shuyun Liu, Quanyi Guo","doi":"10.1002/adhm.71812","DOIUrl":"10.1002/adhm.71812","url":null,"abstract":"<div>\u0000 \u0000 Bone and cartilage defects represent major clinical challenges, with an increasingly urgent need for effective repair and regeneration. In recent years, small RNA-based regulatory strategies, such as microRNAs (miRNAs) and small interfering RNAs (siRNAs), have emerged as promising candidates for promoting bone and cartilage regeneration. However, achieving efficient and safe targeted delivery remains a critical challenge. Tetrahedral framework nucleic acids (tFNAs), a type of three-dimensional DNA nanomaterial with precise structure and excellent biocompatibility, serve dual functions as both intelligent delivery carriers and bioactive scaffolds, offering innovative solutions to this challenge. This review systematically outlines the advantages and research progress of tFNAs in this field, with a particular focus on their latest strategies and mechanisms as carriers for loading small RNAs that promote bone and cartilage regeneration. Additionally, the article summarizes cutting-edge investigations into enhancing the targeting ability, stability, and therapeutic efficacy of tFNAs through functional modifications and integration with biomaterials, and discusses the challenges and future directions for clinical translation.\u0000 </div>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 41","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149101115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Unifying Dental Gel for Enamel-Remineralization, and Whitening Effects 一种用于牙釉质再矿化和美白效果的统一牙科凝胶。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-11-06 Epub Date: 2026-08-16 DOI: 10.1002/adhm.71607

Hong Yue, Xinxue Tang, Jie Zhou, Yunchen Long, Junjie Mao, Chao Fu, Jian Lu, Yang Yang Li

{"title":"A Unifying Dental Gel for Enamel-Remineralization, and Whitening Effects","authors":"Hong Yue, Xinxue Tang, Jie Zhou, Yunchen Long, Junjie Mao, Chao Fu, Jian Lu, Yang Yang Li","doi":"10.1002/adhm.71607","DOIUrl":"10.1002/adhm.71607","url":null,"abstract":"<div>\u0000 \u0000 This study reports a multifunctional dental gel of calcium peroxide-amorphous calcium carbonate phosphate (CaO2-ACCP), capable of synergistically repairing damaged dentin, tooth-whitening, and exerting antibacterial activity. The CaO2 nanoparticles react with water in saliva, releasing Ca2+, OH−, and reactive oxygen species (ROS). The thus-generated alkaline environment and the released Ca2+ ions promote the conversion of the ACCP gel into hydroxyapatite (HAP), which is critical for remineralizing damaged dentin and restoring its microhardness (from 0.1 GPa for acid-etched to 2.0 GPa for remineralized). On the other hand, the gel provides an ultralarge surface for concurrent adsorption of ROS and pigment molecules, enabling efficient stain removal and rapid tooth whitening within 12 h. Simultaneously, the gel effectively suppresses pathogenic bacteria growth (almost 100% sterilized within 24 h) and prevents caries. Through the mechanisms of “ROS confinement buffer” and “Ca2+-driven positive feedback synergy,” an effect of “1+1>2” is achieved. This study demonstrates synergistic intervention across the disease-aesthetic spectrum, promising a gentle and effective solution for comprehensive oral healthcare.\u0000 </div>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 41","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148756833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On-Demand Generation of Patient-Derived Organoids for Precision Oncology: Progress and Prospects 精确肿瘤患者衍生类器官的按需生成：进展和前景。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-11-06 Epub Date: 2026-10-09 DOI: 10.1002/adhm.71817

Ziliang Guo, Shijie Yang, Keyu Shen, Yumeng Liu, Xiequn Xu

{"title":"On-Demand Generation of Patient-Derived Organoids for Precision Oncology: Progress and Prospects","authors":"Ziliang Guo, Shijie Yang, Keyu Shen, Yumeng Liu, Xiequn Xu","doi":"10.1002/adhm.71817","DOIUrl":"10.1002/adhm.71817","url":null,"abstract":"<div>\u0000 \u0000 Precision oncology has become a focus of both clinical practice and basic research. With the rapid evolution of organoid culture techniques and the integration of biomedical engineering approaches, patient-derived organoid (PDO) systems are playing an increasingly pivotal role in precision cancer therapy. By recapitulating patient-specific tumor characteristics, these platforms demonstrate considerable potential for clinical translation.\u0000 Despite remarkable progress, the impact of PDO models on real-world therapeutic decision-making remains limited. Most existing studies have focused on preclinical concept validations or small-scale trials, leaving a substantial gap before these models can be implemented to guide individualized cancer therapy.\u0000 This review examines on-demand PDO generation through the selection of sample-processing methods, matrices, and platform architectures matched to specific treatment-response questions. We compare conventional and engineered systems in terms of biological complexity, sample requirements, reported timelines, assay readouts, and clinical evidence. Particular attention is given to engineering trade-offs and the distinction between technical feasibility, clinical response correlation, and demonstrated utility in treatment selection.\u0000 </div>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 41","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Self-Reinforcing Hydrogel Disrupting Osteoclast Sealing Zone for Bone Erosion Alleviation 一种自我强化水凝胶破坏破骨细胞封闭区以减轻骨侵蚀。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-11-06 Epub Date: 2026-10-06 DOI: 10.1002/adhm.71808

Yilin Wei, Bei Kang, Baohong Liu, Valentin A. Milichko, Wen Li, Yutong Song, Mengyao Zhang, Xinyi Liu, Haobo Wang, Zheyi Li, Weili Liu, Xinxing Wang, Nan Li

{"title":"A Self-Reinforcing Hydrogel Disrupting Osteoclast Sealing Zone for Bone Erosion Alleviation","authors":"Yilin Wei, Bei Kang, Baohong Liu, Valentin A. Milichko, Wen Li, Yutong Song, Mengyao Zhang, Xinyi Liu, Haobo Wang, Zheyi Li, Weili Liu, Xinxing Wang, Nan Li","doi":"10.1002/adhm.71808","DOIUrl":"10.1002/adhm.71808","url":null,"abstract":"<div>\u0000 \u0000 Abnormal remodeling of subchondral bone (SB), driven by osteoclast sealing zone formation and insufficient adaptation to joint mechanical stress, accelerates the progression of osteoarthritis (OA) and remains a major therapeutic challenge. Here, we developed a mechanically self-reinforcing injectable hydrogel in which amino-hydroxyapatite (amHap)-encapsulating spindle-shaped tellurium (Te) nanoparticles (Te@amHap, Team) were embedded within an oxidized alginate-gelatin matrix (Te@amHap/OG Gel, Team Gel). Team Gel contains dynamic Schiff base bonds, enabling controlled release of Team under joint mechanical forces. Within the acidic microenvironment of the osteoclast sealing zone, Team degrades and releases Te to be oxidized into TeO32− by osteoclast-derived H2O2. These ions can react with the thiol-containing residues of F-actin to form Te─S bonds, leading to F-actin degradation to disrupt the sealing zone and suppress bone resorption. Notably, Ca2+ from amHap interacts with alginate to form an egg-box secondary crosslinking structure, enhancing the crosslinking density beyond the original Schiff base network, thereby enhancing the mechanical strength of Team Gel and extending its retention time. Acting together, PO43−-mediated inhibition of osteoclast differentiation and Te-driven disruption of the mature osteoclast sealing zone suppress osteoclastogenesis and bone resorption. This sealing zone disruption strategy preserves bone quality and joint integrity, suggesting a promising osteoclast-targeted therapy for OA.\u0000 </div>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 41","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149101318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epitope-Imprinted Polymer Nanoparticles Enable Selective Recognition of Filamentous Vimentin for Tumor Imaging In Vivo 表位印迹聚合物纳米颗粒能够选择性识别丝状静脉蛋白用于体内肿瘤成像。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-11-06 Epub Date: 2026-10-06 DOI: 10.1002/adhm.71813

Kamaran Khurshid Dar, Yuan Li, Yongqin Lv

{"title":"Epitope-Imprinted Polymer Nanoparticles Enable Selective Recognition of Filamentous Vimentin for Tumor Imaging In Vivo","authors":"Kamaran Khurshid Dar, Yuan Li, Yongqin Lv","doi":"10.1002/adhm.71813","DOIUrl":"10.1002/adhm.71813","url":null,"abstract":"<div>\u0000 \u0000 Vimentin is a cytoskeletal protein upregulated during epithelial-mesenchymal transition that can also be aberrantly displayed on the surface of multiple tumor cell types, making it a promising target for tumor imaging. Here, we develop epitope-imprinted polymer nanoparticles (nanoMIPs) for vimentin recognition through a two-step strategy comprising screening a library of non-imprinted nanoparticles to identify a lead formulation, followed by peptide-directed molecular imprinting. The resulting nanoMIPs exhibited enhanced apparent affinity for vimentin, with picomolar-range KD values, although these values represent model-dependent ensemble apparent affinities that may include contributions from multiple nanoparticle-ligand contacts and local rebinding rather than intrinsic monovalent affinities. The nanoMIPs preferentially bound cancer cells presenting cell-surface vimentin in vitro. The enhanced target binding and reduced off-target binding were consistent with an imprinting-associated improvement in molecular discrimination, although nonspecific physicochemical interactions were not completely eliminated. These findings extend epitope-guided nanoMIP design to structurally dynamic, cell surface-associated cytoskeletal targets, and support the development of synthetic receptors for tumor imaging. In vivo, the optimized nanoMIPs produced a tumor-associated fluorescence signal approximately 1.44 times that of the matched non-imprinted nanoparticles.\u0000 </div>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 41","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149101325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microfluidic Engineering of Microgels: A Review of Emerging Technologies, Materials, Fabrication Strategies, and Applications 微凝胶的微流控工程：新兴技术、材料、制造策略和应用综述。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-11-06 Epub Date: 2026-10-09 DOI: 10.1002/adhm.71809

Afshin Abrishamkar, Laura Neely, Cynthia Pham, Nada Ibrahim, Alexis Larios-Cervantes, Ben A. Kertesz, Todd Hoare

{"title":"Microfluidic Engineering of Microgels: A Review of Emerging Technologies, Materials, Fabrication Strategies, and Applications","authors":"Afshin Abrishamkar, Laura Neely, Cynthia Pham, Nada Ibrahim, Alexis Larios-Cervantes, Ben A. Kertesz, Todd Hoare","doi":"10.1002/adhm.71809","DOIUrl":"10.1002/adhm.71809","url":null,"abstract":"Microparticles of hydrogels, also known as microgels, have garnered extensive attention due to their versatile properties and wide range of applications in different fields of science, technology, and medicine. Among the developed technologies to produce microgels, the precise control over fluid handling offered by microfluidics enables particular fine-tuning of the shape, size, and composition of microgels. This article provides a review of recent progress in the development of microfluidic technologies for the fabrication of microgels based on different hydrogel-based biomaterials for diverse practical applications. The fundamental principles of different microfluidic-based techniques for microgel formation are summarized including chip-based, capillary-based, valve-based, three-dimensional printed, and digital microfluidics. Following, strategies for producing microgels from various natural and synthetic polymers using a range of potential crosslinking techniques with varying sizes, structures (water-in-oil, oil-in-water, higher order emulsion, and core-shell), and morphologies (spherical, non-spherical, Janus, and porous) are discussed in detail. Subsequently, the practical applications of microgels produced via microfluidic technologies are summarized across various fields including cell encapsulation, tissue engineering, particle removal, sensors, and food and nutrition, with current challenges and opportunities highlighted to motivate future research in the field.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 41","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.71809","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “Bioinspired Proteome-Engineered Hydrogels as Vitreous Substitutes for Preserving Intraocular Homeostasis” 更正“生物启发蛋白质组工程水凝胶作为保存眼内稳态的玻璃体替代品”。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-11-06 Epub Date: 2026-09-16 DOI: 10.1002/adhm.71731

引用次数: 0