Advanced Healthcare Materials最新文献_第2页

A Glucose-Fueled Metal-Organic Framework@Nanofiber Membrane Enables Self-Activated Chemodynamic-Photodynamic Therapy for Diabetic Infections. 葡萄糖燃料的金属有机Framework@Nanofiber膜使自激活的化学动力学-光动力学治疗糖尿病感染。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2026-05-07 DOI: 10.1002/adhm.71234

Liefeng Hu, Yahuan Wang, Yan Liu, Ganlin Dong, Jiayi Luo, Shuting Li, Zihan Wang, Yu-Qi Feng

{"title":"A Glucose-Fueled Metal-Organic Framework@Nanofiber Membrane Enables Self-Activated Chemodynamic-Photodynamic Therapy for Diabetic Infections.","authors":"Liefeng Hu, Yahuan Wang, Yan Liu, Ganlin Dong, Jiayi Luo, Shuting Li, Zihan Wang, Yu-Qi Feng","doi":"10.1002/adhm.71234","DOIUrl":"https://doi.org/10.1002/adhm.71234","url":null,"abstract":"Chemodynamic therapy (CDT) and photodynamic therapy (PDT) mediated by reactive oxygen species hold great potential for wound infection management due to their independence from antibiotic resistance. However, chronic wounds with pH > 8 and inadequate H2O2 impair the catalytic efficiency required for CDT, and external light irradiation required for PDT damages normal tissues and hinders wound healing. We herein develop a MOF@nanofiber membrane that enables a precise and efficient combination of controlled self-activated CDT and PDT for diabetic infections. Shuttle-shaped PCN-222 MOF nanoparticles act as photosensitizers and platforms for in situ growth of Au nanoparticles with glucose oxidase-like activity and encapsulation of luminol (Lum). These components are integrated into electrospun nanofibrous membranes composed of polyvinyl alcohol and hyaluronic acid, and crosslinked with Fe2+ to obtain LPA@PHM(Fe). Mechanistically, the membrane is degraded by bacteria-secreted hyaluronidase and H2O2 in infected wounds, producing ·OH and releasing LPA. Au NPs then lower local glucose and pH, and supplement H2O2 to enhance CDT and enable Lum-based chemiluminescence resonance energy transfer-mediated PDT. This synergistic antimicrobial effect is verified in vitro and in diabetic wounds. Applied as a band-aid, LPA@PHM(Fe) shows strong potential for promoting healing of diabetic infected wounds.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71234"},"PeriodicalIF":9.6,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147830968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physicochemical Reinforcement Unlocks Sterilization-Stable Anisotropic Hydrogels for Cell-Compatible Mock Arteries. 物理化学强化解锁灭菌稳定的各向异性水凝胶细胞兼容模拟动脉。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2026-05-07 DOI: 10.1002/adhm.202600010

Javiera Sanhueza Ortega, Kirthen Shanmuganathan, Laura Poole-Warren, Susann Beier, Ulises Aregueta Robles

{"title":"Physicochemical Reinforcement Unlocks Sterilization-Stable Anisotropic Hydrogels for Cell-Compatible Mock Arteries.","authors":"Javiera Sanhueza Ortega, Kirthen Shanmuganathan, Laura Poole-Warren, Susann Beier, Ulises Aregueta Robles","doi":"10.1002/adhm.202600010","DOIUrl":"https://doi.org/10.1002/adhm.202600010","url":null,"abstract":"In vitro arterial models offer ethical and robust alternatives for vascular research but require cytocompatible materials that replicate physiological mechanics. Poly(vinyl alcohol) (PVA) hydrogels produced by directional freezing and salting-out (PVA DFSO) are anisotropic yet lack stability for cell culture. Herein, methacrylated PVA (PVA-MA) hydrogels were fabricated by integrating directional freezing, salting-out, and ultraviolet (UV)-mediated covalent crosslinking to enhance mechanical performance and physicochemical stability. Two fabrication routes were examined: UV polymerization before (UVBSO) or after (UVASO) salting-out. Tensile properties and anisotropy were quantified relative to the freezing direction, and stability was assessed by swelling and mass-loss measurements. UVBSO hydrogels achieved the highest anisotropy (ratio ≈ 3.48), with Young's modulus of 50.8 kPa parallel (E||) and 14.1 kPa perpendicular (E⊥) to freezing direction but reduced stiffness (2.9-fold lower E∥ than DFSO). In contrast, UVASO constructs demonstrated robust, arterial-range performance (tensile strength ≈ 760 kPa; E∥ ≈ 378.6 kPa; ∼2.5-fold vs DFSO; ratio ≈ 3.26), reduced swelling without increasing mass loss, and sterilization compatibility. PVA-MA hydrogels could be molded into artery-like geometries and supported viable cell adhesion. This work presents a sterilizable, cytocompatible hydrogel with tunable anisotropy and arterial-mimetic mechanics, advancing the development of vascular-relevant in vitro artery models.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e00010"},"PeriodicalIF":9.6,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PAM@GO Composite Scaffolds Enhance the Yield of iMEC Exosomes for Accelerated Burn Repair. PAM@GO复合支架提高iMEC外泌体加速烧伤修复的产量。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2026-05-07 DOI: 10.1002/adhm.202505468

Zhigang Lei, Shan Deng, Zhe Sun, Quanhui Liu, Hong Pan, Guodong Wang, Jinmiao Pan, Ben Huang, Dandan Zhang

{"title":"PAM@GO Composite Scaffolds Enhance the Yield of iMEC Exosomes for Accelerated Burn Repair.","authors":"Zhigang Lei, Shan Deng, Zhe Sun, Quanhui Liu, Hong Pan, Guodong Wang, Jinmiao Pan, Ben Huang, Dandan Zhang","doi":"10.1002/adhm.202505468","DOIUrl":"https://doi.org/10.1002/adhm.202505468","url":null,"abstract":"Severe burns trigger widespread tissue necrosis and a persistent inflammatory cascade, demanding the development of advanced biomaterials capable of actively promoting cutaneous regeneration. In this study, we present a multifunctional hydrogel system integrating a polyacrylamide-graphene oxide (PAM@GO) matrix, capable of promoting induced mammary epithelial-like cells (iMECs) to achieve the high-yield production of exosomes (PAM@GO-EXOs-iMECs), and enhance the biological functions. Mechanistically, iMECs exosome biogenesis can be enhanced by both activating RAB27A/B-mediated vesicular trafficking and upregulating the critical MITF-NSMASE2 signaling axis. Furthermore, in vitro assays demonstrated that PAM@GO-EXOs-iMECs significantly stimulated keratinocyte proliferation and migration, alongside robust endothelial tube formation compared to 2D-EXOs-iMECs. The PAM@GO-EXOs-iMECs were subsequently encapsulated within a methoxy polyethylene glycol (MPEG) hydrogel to form a sustained-release bioactive dressing (PAM@GO-EXOs-MPEG). In murine burn models, PAM@GO-EXOs-MPEG accelerated wound closure, improved collagen alignment, and fostered neovascularization compared to 2D-EXOs-iMECs. Meanwhile, proteomic profiling revealed profound enrichment of proteins linked to epidermal development, cytoskeletal reorganization, and inflammatory resolution following treatment with PAM@GO-EXOs-MPEG. Collectively, this work establishes an innovative PAM@GO scalable platform for significantly promoting exosome production and introduces a clinically translatable exosome-hydrogel hybrid with substantial regenerative potential for severe burn repair.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e05468"},"PeriodicalIF":9.6,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microencapsulated Glass Ionomer Cement-Driven Dental Self-Healing Resin Composites With Enhanced Mechanical Strength, Biocompatibility, and Reparative Dentin Formation. 微胶囊化玻璃离聚体水泥驱动的牙科自愈树脂复合材料具有增强的机械强度、生物相容性和修复性牙本质形成。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2026-05-07 DOI: 10.1002/adhm.202505543

Yanyan Han, Junjun Wang, Dan Lin, Jiali Wang, Qinyan Zhu, Yizhang Yang, Yuqing Chen, Meifang Zhu, Ruili Wang, Yaqin Zhu

{"title":"Microencapsulated Glass Ionomer Cement-Driven Dental Self-Healing Resin Composites With Enhanced Mechanical Strength, Biocompatibility, and Reparative Dentin Formation.","authors":"Yanyan Han, Junjun Wang, Dan Lin, Jiali Wang, Qinyan Zhu, Yizhang Yang, Yuqing Chen, Meifang Zhu, Ruili Wang, Yaqin Zhu","doi":"10.1002/adhm.202505543","DOIUrl":"https://doi.org/10.1002/adhm.202505543","url":null,"abstract":"Long-term applications of dental resin composites are restricted by their limited service lives due to microcrack-induced fractures, while existing self-healing systems face challenges including insufficient biocompatibility and a lack of standardized evaluation. A self-healing resin composite incorporating glass ionomer cement-based silica microcapsules (GIC-SiO2 MCs) was developed with controlled particle size covering macro- and micro-fillers via optimized synthetic parameters. Microcracks ruptured MCs, releasing healing liquid that reacted with powder in the resin matrix to form crack-sealing GIC. An optimal MCs ratio of 10wt% significantly improved hydrophilicity, flexural strength (from 58.6 to 87.8 MPa, reaching ISO standard), and cytocompatibility. A systematic methodology of self-healing efficiency evaluation was established, integrating morphological and mechanical restoration. The 10 wt.% MC-filled resin showed superior scratch closure in area and depth, recovery of fracture toughness (256.6%), and the highest comprehensive healing efficiency (161.2%). In a rat model, the 10 wt.% MC-incorporated resin elicited mild inflammatory responses and significantly enhanced reparative dentin formation, previously unreported in resin-based material. The developed self-healing resin composite combined enhanced mechanical properties, autonomous self-healing, anti-caries activity, and bioactivity for remineralization and reparative dentin formation. This work offered a pioneering strategy and evaluative foundation for developing clinically applicable self-healing dental materials, bridging the gap between experimental innovation and clinical practice.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e05543"},"PeriodicalIF":9.6,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147830972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-Printhead Parallel Printing of Polycaprolactone Barrier/Filler-Integrated Scaffolds for Alveolar Bone Repair. 多喷头平行打印聚己内酯屏障/填充物集成支架用于牙槽骨修复。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2026-05-07 DOI: 10.1002/adhm.202505588

Zijie Meng, Na Li, Jianzhen She, Le Wang, Yabo Zhang, Yanwen Su, Kaixin Shi, Bolei Cai, Dichen Li, Liang Kong, Jiankang He

{"title":"Multi-Printhead Parallel Printing of Polycaprolactone Barrier/Filler-Integrated Scaffolds for Alveolar Bone Repair.","authors":"Zijie Meng, Na Li, Jianzhen She, Le Wang, Yabo Zhang, Yanwen Su, Kaixin Shi, Bolei Cai, Dichen Li, Liang Kong, Jiankang He","doi":"10.1002/adhm.202505588","DOIUrl":"https://doi.org/10.1002/adhm.202505588","url":null,"abstract":"Most current guided bone regeneration (GBR) procedures rely on manual assembly of membranes and filler materials during surgery, which often results in reduced shape fidelity, potential loss or displacement of graft powder, decreased operational efficiency and consistency. Here, we propose a multi-printhead parallel printing strategy for the fabrication of barrier/filler-integrated GBR scaffolds for alveolar bone repair by upgrading a conventional melt extrusion-based printing system with a parallelized 10-printhead module. Compared with conventional single-printhead system, the parallel 10-printhead configuration introduces thermal crosstalk, elevating local temperatures near the building platform and hindering the proper solidification of printed structures. By implementing cooling convection via fans and temperature compensation, we achieved simultaneous printing of 10 thin-wall membrane structures with consistent geometry and interlayer-bonding strength. Moreover, the system enables parallel printing of triply periodic minimal surface (TPMS) porous structures and barrier/filler-integrated GBR scaffolds, substantially enhancing overall manufacturing efficiency. In vivo studies using a rabbit alveolar defect model further demonstrated that the parallel-printed integrated scaffolds effectively prevented soft tissue invasion while promoting robust bone regeneration, achieving outcomes superior to those of clinically established GBR strategies. The proposed multi-printhead parallel printing technique offers a scalable, efficient way to mass-produce clinically applicable polymeric implants.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e05588"},"PeriodicalIF":9.6,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fully Wireless and Flexible Valves for Multiplexed and Prolonged Intravesical Liquid Release. 用于多路和长时间膀胱内液体释放的全无线和柔性阀门。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2026-05-07 DOI: 10.1002/adhm.71197

Boyang Xiao, Yi Zhu, Yusheng Wang, Janene M Pierce, Jeffrey J Tosoian, Xiaoguang Dong

{"title":"Fully Wireless and Flexible Valves for Multiplexed and Prolonged Intravesical Liquid Release.","authors":"Boyang Xiao, Yi Zhu, Yusheng Wang, Janene M Pierce, Jeffrey J Tosoian, Xiaoguang Dong","doi":"10.1002/adhm.71197","DOIUrl":"https://doi.org/10.1002/adhm.71197","url":null,"abstract":"Minimally invasive, long-term, and precisely controlled drug delivery is essential for treating bladder diseases such as interstitial cystitis and bladder cancer. However, conventional approaches, including injection-based delivery and indwelling catheters, offer limited controllability, cause patient discomfort, and increase the risk of infection and tissue irritation. Existing intravesical devices further lack active control over drug release, are restricted to single therapeutic agents, and may induce bladder overactivity due to continuous mechanical stimulation. Here, we present a strategy to remotely control multiple flexible magnetic valves on a soft robotic patch for controlled, multiplexed, and sustained liquid delivery. The device integrates magnetic valves with soft osmotic pumps to achieve precise dosing, selective release, and on-demand mixing of multiple therapeutics. Release rates are tuned by modulating valve duty cycles, while coordinated multi-valve actuation enables independent ejection and programmable mixing. A bioadhesive soft patch provides stable attachment to wet bladder tissue for over seven days. Wireless, selective valve control is achieved using a portable magnetic actuation system with wireless sensing feedback. Phantom and ex vivo porcine bladder studies demonstrate robust adhesion, controlled multiplexed delivery, and long-term operational stability. This platform establishes a foundation for minimally invasive and on-demand intravesical therapy for precision medicine.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71197"},"PeriodicalIF":9.6,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Biomimetic Palpation Platform for the Quantitative and Non-Invasive Assessment of Tissue Compliance. 用于组织顺应性定量和无创评估的仿生触诊平台。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2026-05-06 DOI: 10.1002/adhm.71212

Joongmi Kim, Yu-Jin Lee, Myoung-Ock Cho, Seunghwan Seo, Kyoung-Yong Chun, Chang-Soo Han

{"title":"A Biomimetic Palpation Platform for the Quantitative and Non-Invasive Assessment of Tissue Compliance.","authors":"Joongmi Kim, Yu-Jin Lee, Myoung-Ock Cho, Seunghwan Seo, Kyoung-Yong Chun, Chang-Soo Han","doi":"10.1002/adhm.71212","DOIUrl":"https://doi.org/10.1002/adhm.71212","url":null,"abstract":"Physiological palpation serves as a primary clinical modality for identifying pathological changes in tissue compliance. However, its diagnostic precision is inherently limited by the subjective nature of human haptic perception and the lack of quantifiable mechanical metrics. This work describes a bio-inspired, portable tactile interface engineered for the non-invasive and real-time characterization of tissue stiffness. The system incorporates multimodal piezoresistive sensing elements that emulate the specific mechanotransduction functions of cutaneous receptors, namely Merkel disks and Ruffini endings. By integrating Hertzian contact mechanics to decouple pressure and strain signals, the platform analytically derives the effective Young's modulus of heterogeneous soft tissues. The developed sensor architecture exhibits a functional range of 0-600 kPa and a gauge factor of 10.8, facilitating high-fidelity detection of subcutaneous anomalies. Validation against various nodule geometries and depths demonstrates that the system achieves a diagnostic resolution surpassing conventional manual assessments. Furthermore, the integration of wireless data processing enables instantaneous, on-site mechanical profiling. This platform provides a scalable framework for objective diagnostics, robotic haptics, and continuous physiological monitoring, establishing a robust bridge between qualitative clinical observation and quantitative biomechanical analysis.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71212"},"PeriodicalIF":9.6,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147830916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a Synthetic Hydrogel to Foster Microvascularization of an Endometriosis Microphysiological System. 促进子宫内膜异位症微生理系统微血管化的合成水凝胶的研制。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2026-05-06 DOI: 10.1002/adhm.202504936

Lauren Pruett, Laura Bahlmann, Ryan Ogi, Angela Jiao, Priyatanu Roy, Matthew Johnson, David Trumper, Linda Griffith

{"title":"Development of a Synthetic Hydrogel to Foster Microvascularization of an Endometriosis Microphysiological System.","authors":"Lauren Pruett, Laura Bahlmann, Ryan Ogi, Angela Jiao, Priyatanu Roy, Matthew Johnson, David Trumper, Linda Griffith","doi":"10.1002/adhm.202504936","DOIUrl":"https://doi.org/10.1002/adhm.202504936","url":null,"abstract":"The ascent of novel alternative methods in drug development spotlights the dual needs for improved biological fidelity to in vivo, along with reproducibility, especially in regulatory applications. The need for pre-clinical models of patient-derived endometriosis lesions motivates the development of a vascularizable, completely synthetic extracellular matrix (v-CS-ECM) that supports morphogenesis of perfusable microvasculature in a microfluidic device, in the context of relevant lesion cells. This paper describes v-CS-ECM, a peptide-modified polyethylene glycol-based hydrogel crosslinked with a cell-degradable peptide that achieves these dual goals. Vessels form by morphogenesis after the liquid v-CS-ECM precursor, containing endothelial cells and fibroblasts, is injected into the tissue compartment to encapsulate cells. Vessel formation is influenced by ECM biochemical and biophysical properties, the source of vascular cells, and microphysiological system operating conditions. The v-CS-ECM also supports the co-culture of endometrial epithelial organoids and fibroblasts, and formation of microvascularized endometriosis lesion-like structures when all cell types are co-encapsulated in a microfluidic device with constant flow. Hence, v-CS-ECM has the potential to improve preclinical evaluation of endometriosis drug efficacy by enabling microvascularized patient-derived lesion models.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e04936"},"PeriodicalIF":9.6,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One-Step Formation of Hierarchical Hydrogel Patch by Self-Gelling and Phase Separation Promotes Oral Ulcer Treatment via One-Sided Tissue Adhesion, Antibacterial, and Anti-Inflammatory Properties. 通过自凝胶和相分离一步形成分层水凝胶贴片，通过单侧组织粘附、抗菌和抗炎特性促进口腔溃疡治疗。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2026-05-06 DOI: 10.1002/adhm.71232

Hongbo Yu, Zhenan Li, Chuhan Lv, Zibo Liu, Hua Dong

{"title":"One-Step Formation of Hierarchical Hydrogel Patch by Self-Gelling and Phase Separation Promotes Oral Ulcer Treatment via One-Sided Tissue Adhesion, Antibacterial, and Anti-Inflammatory Properties.","authors":"Hongbo Yu, Zhenan Li, Chuhan Lv, Zibo Liu, Hua Dong","doi":"10.1002/adhm.71232","DOIUrl":"https://doi.org/10.1002/adhm.71232","url":null,"abstract":"The therapeutic effect of traditional oral ulcer medications is limited, due to their complex synthetic routes, weak wet tissue adhesion, and poor bioactivity. To address these issues, a novel sprayable self-gelling powder composed of polyacrylic acid (PAA), quaternized chitosan (QCS) and puerarin (PUE) is developed, which can absorb saliva quickly and form a hydrogel patch in situ at the ulcer site through hydrogen bonding and ionic interactions. More importantly, this hydrogel patch undergoes phase separation under excessive flowing saliva and spontaneously converts into a hierarchical structure with a non-adhesive top PUE layer and an adhesive bottom PAA/QCS/PUE layer, avoiding unexpected adhesion between the hydrogel patch and adjacent tissues except oral ulcer site. In addition, this hierarchical hydrogel patch also exhibits excellent antibacterial and anti-inflammatory properties, as proven by the universal antibacterial performance toward multiple bacteria, high reactive oxygen species (ROS) scavenging capacity and promotion of macrophages from M1 to M2 types. Owing to the synergism among good one-sided tissue adhesion, antibacterial and anti-inflammatory properties, in vivo wound healing of rabbit oral mucosa defect can be realized efficiently using self-gelling PAA/QCS/PUE powders.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71232"},"PeriodicalIF":9.6,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-Assembling Biohybrid Bands of Büngner for Axonal Regeneration in the Peripheral Nervous System. 外周神经系统轴突再生用bngner自组装生物杂交带。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2026-05-06 DOI: 10.1002/adhm.202504185

Atocha Guedan-Duran, Nahla Jemni-Damer, Yasmine Owen, Antonio Murciano, Maria-Dolores Gimeno García-Andrade, Assunta Virtuoso, Giovanni Cirillo, Michele Papa, Fivos Panetsos

{"title":"Self-Assembling Biohybrid Bands of Büngner for Axonal Regeneration in the Peripheral Nervous System.","authors":"Atocha Guedan-Duran, Nahla Jemni-Damer, Yasmine Owen, Antonio Murciano, Maria-Dolores Gimeno García-Andrade, Assunta Virtuoso, Giovanni Cirillo, Michele Papa, Fivos Panetsos","doi":"10.1002/adhm.202504185","DOIUrl":"https://doi.org/10.1002/adhm.202504185","url":null,"abstract":"There is broad consensus that successful repair of severe peripheral nerve injuries requires recreating key structural and cellular features of the natural regenerative process, particularly the action of Bands of Büngner (BoB), longitudinal Schwann cell (SC) structures that guide regenerating axons. Current biomaterial-based strategies have shown limited efficacy, in part because they do not sufficiently reproduce the anisotropic and cellular microenvironment established by BoB, resulting in disorganized axonal growth and reduced regenerative efficiency across long gaps. To address this limitation, a biohybrid scaffold designed to promote Schwann cell self-organization into Büngner-like structures through defined physical cues. Rather than relying solely on biochemical supplementation is developed, this system leverages anisotropic fiber architecture to induce SC alignment and early activation-associated phenotypic modulation. In this study, a self-organizing biohybrid BoB (BBoB) construct formed by Schwann cells within an aligned fiber-based scaffold is presented. It is demonstrated that these engineered structures recapitulate key morphological features of native BoB in vitro and promote enhanced axonal regeneration across a 11 mm sciatic nerve defect in vivo. Together, these findings support the concept that physically programmed Schwann cell organization within biomaterial conduits can enhance peripheral nerve regeneration, using clinically accessible biomaterials and autologous Schwann cells.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e04185"},"PeriodicalIF":9.6,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0