Advanced Healthcare Materials最新文献_第2页

Issue Information: Adv. Healthcare Mater. 5/2025 发行信息：Adv.5/2025

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-02-18 DOI: 10.1002/adhm.202570029

引用次数: 0

Modeling of a Bioengineered Immunomodulating Microenvironment for Cell Therapy (Adv. Healthcare Mater. 5/2025)

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-02-18 DOI: 10.1002/adhm.202570028

Simone Capuani, Jocelyn Nikita Campa-Carranza, Nathanael Hernandez, Corrine Ying Xuan Chua, Alessandro Grattoni

引用次数: 0

Biofabrication Directions in Recapitulating the Immune System-on-a-Chip (Adv. Healthcare Mater. 5/2025)

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-02-18 DOI: 10.1002/adhm.202570027

Robine Janssen, Laura Benito-Zarza, Pim Cleijpool, Marta G. Valverde, Silvia M Mihăilă, Shanna Bastiaan-Net, Johan Garssen, Linette E. M. Willemsen, Rosalinde Masereeuw

引用次数: 0

A Microneedle Patch Delivers Mitochondria- and Lysosomes- Dual Targeting Prodrug-Like Photosensitizers with Regulated Photoactivity for Precise Photodynamic Therapy.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-02-18 DOI: 10.1002/adhm.202403954

Zheng Liu, Zhimin Tang, Ying Yin, Miaojian Wan, Jiezhao Zhan, Li Ren

{"title":"A Microneedle Patch Delivers Mitochondria- and Lysosomes- Dual Targeting Prodrug-Like Photosensitizers with Regulated Photoactivity for Precise Photodynamic Therapy.","authors":"Zheng Liu, Zhimin Tang, Ying Yin, Miaojian Wan, Jiezhao Zhan, Li Ren","doi":"10.1002/adhm.202403954","DOIUrl":"https://doi.org/10.1002/adhm.202403954","url":null,"abstract":"Antitumor photodynamic therapy (PDT) faces huge challenges as selectivity and phototoxic damage, requiring delivery photosensitizers (PSs) to specifically accumulate in tumors even in organelle, and avoid the phototoxic damage during delivery. Herein, a microneedle patch (AIE-mito-TPP@MN) containing mitochondria- and lysosomes- dual targeting prodrug-like PSs (AIE-mito-TPP/AlPcSNa4) that is self-assembled by mitochondria-targeted aggregation-induced-emission molecule (AIE-mito-TPP) and lysosome-targeted aluminum phthalocyanine tetrasulfonate (AlPcSNa4), is developed to achieve cancer-cell-organelle-specific targeting delivery for precise PDT with high selectivity and low phototoxic damage. AIE-mito-TPP/AlPcSNa4 displays prodrug-like activity via the regulated photoactivity to reduce the phototoxic damage caused by the \"always on\" PSs. Meanwhile, AIE-mito-TPP/AlPcSNa4@MN can insert into the epidermis to achieve rapid AIE-mito-TPP/AlPcSNa4 delivery in tumor lesion, and enhance selective accumulation in tumor cells. The higher lysosomal acidity in tumor cells facilitates AIE-mito-TPP/AlPcSNa4 disassembly and promotes targeting. Under light irradiation, AIE-mito-TPP/AlPcSNa4@MN impairs mitochondrial and lysosomal function to induce deeper tumor cells apoptosis at a low dose (≈6 µg), presenting greater therapeutic efficacy than AIE-mito-TPP@MN, AlPcSNa4@MN, or intravenous injection. Moreover, AIE-mito-TPP/AlPcSNa4@MN presents good biocompatibility as lower accumulation and targeting in normal cells, as well as the regulated photoactivity of prodrug-like PSs. Therefore, the dual organelle-targeting microneedle possesses great potential for precise PDT with high selectivity.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403954"},"PeriodicalIF":10.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymerized Salicylic Acid Microparticles Reduce the Progression and Formation of Human Neutrophil Extracellular Traps (NET)s (Adv. Healthcare Mater. 5/2025)

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-02-18 DOI: 10.1002/adhm.202570030

Emma R. Brannon, Logan D. Piegols, Gillian Cady, Daniel Kupor, Xueqi Chu, M. Valentina Guevara, Mariana R.N. Lima, Yogendra Kanthi, David J. Pinsky, Kathryn E. Uhrich, Omolola Eniola-Adefeso

引用次数: 0

Multieffect Specific Nanovesicles for Homing Resistant Tumors and Overcoming Osimertinib-Acquired Resistance in NSCLC.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-02-18 DOI: 10.1002/adhm.202404087

Yuanyao Dou, Yihui Liu, Rui Han, Jie Zheng, Liping Wang, Chen Hu, Daijuan Huang, Chao He, Yimin Zhang, Caiyu Lin, Conghua Lu, Di Wu, Huan Tang, Tingting He, Liling Tang, Yong He

{"title":"Multieffect Specific Nanovesicles for Homing Resistant Tumors and Overcoming Osimertinib-Acquired Resistance in NSCLC.","authors":"Yuanyao Dou, Yihui Liu, Rui Han, Jie Zheng, Liping Wang, Chen Hu, Daijuan Huang, Chao He, Yimin Zhang, Caiyu Lin, Conghua Lu, Di Wu, Huan Tang, Tingting He, Liling Tang, Yong He","doi":"10.1002/adhm.202404087","DOIUrl":"https://doi.org/10.1002/adhm.202404087","url":null,"abstract":"Acquired resistance to osimertinib (Osi) remains a major obstacle in the treatment of patients with EGFR-mutant non-small cell lung cancer (NSCLC). AXL elevation is a known key mechanism of Osi-resistance, and therapeutic strategies remain scarce. Emerging evidence reveals that an increased intracellular glutathione (GSH) level induces Osi resistance. In this study, a new mechanism is identified by which GSH regulates AXL expression via glutathione peroxidase 4 (GPX4) in Osi-resistant cells. A multifunctional covalent organic framework (COF) nanoplatform for GSH consumption, AXL inhibition, and co-delivery of the AXL inhibitor (Brigatinib) and Osi is creatively constructed to confirm whether Osi sensitivity improves by simultaneously targeting GSH-AXL resistance mechanisms. Furthermore, it is coated, for the first time, the COF carrier system with specific vesicles to precisely home it into resistant tumors, where CDH2 adhesion molecules play a crucial role. The engineered multifunctional antiresistance-specific nanovesicles effectively inhibited the GSH-AXL axis, induced apoptosis in Osi-resistant cells both in vitro and in vivo, and delayed the progression of Osi-resistant tumors. Overall, these findings provide a novel strategy to overcome the Osi-acquired resistance caused by high AXL levels in NSCLC.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2404087"},"PeriodicalIF":10.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mimicking the Dystrophic Cardiac Extracellular Environment through DystroGel.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-02-17 DOI: 10.1002/adhm.202404251

Maila Chirivì, Fabio Maiullari, Marika Milan, Maria Grazia Ceraolo, Nicole Fratini, Alessandra Fasciani, Salma Bousselmi, Michael Stirm, Francesca Scalera, Francesca Gervaso, Michela Villa, Raffaello Viganò, Francesca Brambilla, Pierluigi Mauri, Elena De Falco, Dario Di Silvestre, Marco Costantini, Eckhard Wolf, Claudia Bearzi, Roberto Rizzi

{"title":"Mimicking the Dystrophic Cardiac Extracellular Environment through DystroGel.","authors":"Maila Chirivì, Fabio Maiullari, Marika Milan, Maria Grazia Ceraolo, Nicole Fratini, Alessandra Fasciani, Salma Bousselmi, Michael Stirm, Francesca Scalera, Francesca Gervaso, Michela Villa, Raffaello Viganò, Francesca Brambilla, Pierluigi Mauri, Elena De Falco, Dario Di Silvestre, Marco Costantini, Eckhard Wolf, Claudia Bearzi, Roberto Rizzi","doi":"10.1002/adhm.202404251","DOIUrl":"https://doi.org/10.1002/adhm.202404251","url":null,"abstract":"Advances in understanding the mechanisms behind genetic diseases like Duchenne muscular dystrophy (DMD) underscore the critical role of the extracellular matrix (ECM) composition in disease progression. Effective in vitro models must replicate the intercellular relationships and physicochemical properties of native ECM to fully capture disease-specific characteristics. Although recent biomaterials support the in vitro biofabrication of pathophysiological environments, they often lack disease-specific ECM features. In this study, DystroGel, a hydrogel derived from the cardiac ECM of a porcine DMD model, replicates the distinct molecular composition of dystrophic cardiac tissue for the first time. The findings indicate that the dystrophic ECM matrix exhibits a unique protein profile, impacting cellular processes critical to DMD pathology. This work demonstrates the importance of using a 3D substrate that recreates intercellular dynamics within a defined pathological environment, enhancing the ability to model genetic disorders and providing a valuable tool for advancing personalized therapeutic strategies.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2404251"},"PeriodicalIF":10.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional Carbon Quantum Dots for Monitoring and Therapy of Bacterial Infected Wounds.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-02-17 DOI: 10.1002/adhm.202403670

Wenxin Qi, Yihao Liu, Naijun Dong, Mengting Li, Jianxin Zhou, Yijun Xie, Qing Chang, Benxiang Luo, Christian Celia, Jiao Wang, Robert Chunhua Zhao, Xiaoyong Deng

{"title":"Multifunctional Carbon Quantum Dots for Monitoring and Therapy of Bacterial Infected Wounds.","authors":"Wenxin Qi, Yihao Liu, Naijun Dong, Mengting Li, Jianxin Zhou, Yijun Xie, Qing Chang, Benxiang Luo, Christian Celia, Jiao Wang, Robert Chunhua Zhao, Xiaoyong Deng","doi":"10.1002/adhm.202403670","DOIUrl":"https://doi.org/10.1002/adhm.202403670","url":null,"abstract":"Bacterial infections in wounds and bacteremia present significant global health challenges, driving the urgent need for innovative alternatives to traditional antibiotics. Here, the development of PEI-EDTA-2Na carbon quantum dots (PECDs) synthesized via a hydrothermal method is reported. Synthesis conditions affect PECDs' antibacterial efficacy; those at 180 °C have optimal -NH2 functionalization for better adhesion and activity. PECDs are pH - responsive, eradicating bacteria in weakly acidic conditions by disrupting DNA and proteins. Following the resolution of infection, PECDs adapt to neutral and alkaline environments, where they scavenge reactive oxygen species (ROS), reduce inflammation, promote macrophage polarization, and accelerate wound healing. Furthermore, PECDs significantly improve survival in bacteremia models. Their intrinsic fluorescence enables real-time pH monitoring of wounds, offering a non-invasive diagnostic tool. Genomic and transcriptomic analyses reveal that PECDs disrupt bacterial metabolism and resistance pathways, while simultaneously supporting antibacterial and anti-inflammatory responses during tissue repair. This dual functionality-combining therapeutic efficacy in wound healing with antimicrobial and anti-inflammatory properties in bacteremia-positions PECDs as a versatile platform for smart wound management and an emerging candidate for advanced biomedical applications.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403670"},"PeriodicalIF":10.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tailored Liposomal Nanomedicine Suppresses Incomplete Radiofrequency Ablation-Induced Tumor Relapse by Reprogramming Antitumor Immunity.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-02-17 DOI: 10.1002/adhm.202403979

Duo Wang, Tianqi Nie, Yifei Fang, Linzhu Zhang, Chao Yu, Ming Yang, Ruijie Du, Junjie Liu, Lei Zhang, Liangzhu Feng, Haidong Zhu

{"title":"Tailored Liposomal Nanomedicine Suppresses Incomplete Radiofrequency Ablation-Induced Tumor Relapse by Reprogramming Antitumor Immunity.","authors":"Duo Wang, Tianqi Nie, Yifei Fang, Linzhu Zhang, Chao Yu, Ming Yang, Ruijie Du, Junjie Liu, Lei Zhang, Liangzhu Feng, Haidong Zhu","doi":"10.1002/adhm.202403979","DOIUrl":"https://doi.org/10.1002/adhm.202403979","url":null,"abstract":"Radiofrequency ablation (RFA), a thermoablative treatment for small hepatocellular carcinoma (HCC), has limited therapeutic benefit for advanced HCC patients with large, multiple, and/or irregular tumors owing to incomplete RFA (iRFA) of the tumor mass. It is first identified that iRFA-treated tumors exhibited increased pyruvate kinase M2 (PKM2) expression, exacerbated tumor immunosuppression featured with increased tumor infiltration of suppressive immune cells and increased proliferation, and programmed cell death ligand 1 expression of cancer cell and ultimately a poor prognosis. Herein, a multifunctional nanomedicine is fabricated by encapsulating nanoassemblies of anti-PD-L1 and spermidine-grafted oxidized dextran with shikonin-containing lipid bilayers to reverse iRFA-induced treatment failure. Shikonin, a PKM2 inhibitor, is used to suppress glycolysis in cancer cells, while anti-PD-L1 and spermidine are introduced to collectively reprogram the proliferation and functions of infiltrated CD8+ T lymphocytes. Combined with iRFA, which promoted the exposure of tumor antigens, the intravenous injection of liposomal SPS-NPs effectively stimulated dendritic cell maturation and reversed tumor immunosuppression, thus eliciting potent antitumor immunity to synergistically suppress the growth of residual tumor masses and lung metastasis. The as-prepared liposomal nanomedicine is promising for potentiating the therapeutic benefits of RFA toward advanced HCC patients through reprogramming iRFA-induced tumor immunosuppression.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403979"},"PeriodicalIF":10.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune-Infiltrated Cancer Spheroid Model with Vascular Recirculation Reveals Temporally Dependent and Tissue-Specific Macrophage Recruitment.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-02-17 DOI: 10.1002/adhm.202402946

Feng Zhang, Kimia Asadi Jozani, Anushree Chakravarty, Dawn Lin, Andrew Hollinger, Shravanthi Rajasekar, Boyang Zhang

{"title":"Immune-Infiltrated Cancer Spheroid Model with Vascular Recirculation Reveals Temporally Dependent and Tissue-Specific Macrophage Recruitment.","authors":"Feng Zhang, Kimia Asadi Jozani, Anushree Chakravarty, Dawn Lin, Andrew Hollinger, Shravanthi Rajasekar, Boyang Zhang","doi":"10.1002/adhm.202402946","DOIUrl":"https://doi.org/10.1002/adhm.202402946","url":null,"abstract":"Immune cell infiltration in tumors has been reported to influence tumor progression and clinical outcomes. Considerable efforts have been made to understand interactions between tumors and the immune system. However, current models are either not comprehensive or limited to short-term studies. Recognizing thedynamic and long-term nature of tumor-immune interactions, an immune-infiltrated cancer spheroid model is developed by continuously perfusing and recirculating immune cells with gravity-driven flow through a tubular blood vessel adjacent to a cancer spheroid. Fibroblasts and pericytes are embedded in the gel matrix to support endothelial cells and enhance the vascular barrier. With continuous monocyte recirculation, monocyte adhesion, transendothelium migration, differentiation, and macrophage recruitment into breast carcinoma and hepatoma spheroids is successfully demonstrated over a week. The macrophage recruitment process is temporally dependent and tissue-specific, leading to the formation of cancer-macrophage heterospheroids. Elevated secretion of granulocyte-macrophage colony-stimulating factor (GM-CSF), which regulates monocyte recruitment and macrophage activation, is observed in the breast carcinoma model. Increased levels of Interleukin 6 (IL-6) and Interleukin 8 (IL-8) are detected, indicating a pro-inflammatory environment associated with tumor progression and metastasis. This platform provides a valuable framework for investigating immune cell infiltration and differentiation within the tumor microenvironment, supporting the advancement of cancer immunotherapies.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2402946"},"PeriodicalIF":10.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0