Advanced Healthcare Materials最新文献_第2页

Advancing Cellular-Specific Delivery: Machine Learning Insights into Lipid Nanoparticles Design and Cellular Tropism (Adv. Healthcare Mater. 18/2025) 推进细胞特异性递送：机器学习洞察脂质纳米颗粒设计和细胞趋向性（Adv. Healthcare Mater. 18/2025）

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-07-16 DOI: 10.1002/adhm.202570107

Belal I. Hanafy, Michael J. Munson, Ramesh Soundararajan, Sara Pereira, Audrey Gallud, Sajib Md Sanaullah, Gianluca Carlesso, Mariarosa Mazza

引用次数: 0

Issue Information: Adv. Healthcare Mater. 18/2025 发布信息：Adv. Healthcare Mater. 18/2025

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-07-16 DOI: 10.1002/adhm.202570108

引用次数: 0

Advances in Stimuli-Responsive Release Strategies for Sonosensitizers in Synergistic Sonodynamic Immunotherapy against Tumors. 超声致敏剂刺激反应性释放策略在协同声动力免疫治疗肿瘤中的研究进展。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-07-16 DOI: 10.1002/adhm.202502183

Rui Ding, Hongyu Yang, Jiaxin Wang, Yuejuan Liu, Sen Mu, Dongkai Wang, Ji Li

{"title":"Advances in Stimuli-Responsive Release Strategies for Sonosensitizers in Synergistic Sonodynamic Immunotherapy against Tumors.","authors":"Rui Ding, Hongyu Yang, Jiaxin Wang, Yuejuan Liu, Sen Mu, Dongkai Wang, Ji Li","doi":"10.1002/adhm.202502183","DOIUrl":"https://doi.org/10.1002/adhm.202502183","url":null,"abstract":"Despite intensive efforts to develop diagnostic and therapeutic tools, the successful treatment of cancer is still hampered by uncontrolled tumor proliferation and metastasis. Sonodynamic therapy (SDT) is a cutting-edge, noninvasive treatment modality that activates sonosensitizers via low-intensity ultrasound (US) to generate reactive oxygen species (ROS), offering deep tissue penetration, low phototoxicity, and minimal side effects. Beyond direct cytotoxicity, it can trigger immunogenic cell death (ICD), thereby enhancing systemic antitumor immune responses. However, its efficacy is constrained by the immunosuppressive tumor microenvironment (ITME). To address these limitations, growing research efforts have focused on dual therapeutic strategies that combine SDT with tumor immunotherapy. These strategies are designed to enhance tumor-specific accumulation of sonosensitizers through stimuli-responsive release mechanisms. SDT activates immune pathways and induces ICD, thus remodeling the tumor microenvironment (TME) and converting immunologically \"cold\" tumors into \"hot\" tumors. This transformation effectively addresses the low response rates and immune-related adverse events associated with immunotherapy, while enhancing immune recognition and tumor clearance. This review summarizes recent advances in the development of stimuli-responsive release strategies for sonosensitizers in sonodynamic immunotherapy, discusses the challenges hindering clinical translation, and underscores the potential of this dual therapeutic strategy in advancing cancer treatment.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2502183"},"PeriodicalIF":10.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in Dual-Function Janus Membranes for Guided Periodontal and Bone Regeneration. 引导牙周和骨再生的双功能Janus膜研究进展。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-07-16 DOI: 10.1002/adhm.202502888

Ying Li, Yeying Lin, Tianhua Xiao, Wen Liu, Chengyun Ning, Guoxin Tan, Lei Zhou

{"title":"Recent Advances in Dual-Function Janus Membranes for Guided Periodontal and Bone Regeneration.","authors":"Ying Li, Yeying Lin, Tianhua Xiao, Wen Liu, Chengyun Ning, Guoxin Tan, Lei Zhou","doi":"10.1002/adhm.202502888","DOIUrl":"https://doi.org/10.1002/adhm.202502888","url":null,"abstract":"Guided Tissue Regeneration (GTR) and Guided Bone Regeneration (GBR) are essential surgical techniques in periodontal therapy, employing barrier membranes to prevent soft tissue infiltration and create a conducive environment for bone regeneration. However, the regenerative performance of conventional barrier membranes remains limited due to poor interface management and insufficient biological functionality. Recent developments have introduced the concept of Janus membranes-structures with asymmetric, dual-function surfaces-offering promising solutions to these challenges. While various reviews have addressed barrier membranes for periodontal and bone regeneration, comprehensive reviews specifically focusing on multifunctional Janus membranes are still limited. This review highlights recent advances in Janus membrane design for GTR and GBR applications. It first outlines key structural configurations, followed by an in-depth analysis of fabrication techniques and functional strategies, including osteogenesis promotion, antibacterial activity, and immunomodulation. By summarizing current progress and challenges, this review offers valuable insights into next-generation biomaterial development for periodontal regeneration. Looking forward, Janus membranes represent a compelling avenue for enhancing clinical outcomes in GTR and GBR procedures.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2502888"},"PeriodicalIF":10.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumor-Targeted Exosome-Based Heavy Atom-Free Nanosensitizers With Long-Lived Excited States for Safe and Effective Sono-Photodynamic Therapy of Solid Tumors (Adv. Healthcare Mater. 18/2025) 基于肿瘤靶向外泌体的长寿命激发态重原子无纳米增敏剂用于安全有效的实体肿瘤声光动力治疗（adh . Healthcare Mater. 18/2025）

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-07-16 DOI: 10.1002/adhm.202570106

Van-Nghia Nguyen, Thuy Giang Nguyen Cao, Hyunsun Jeong, Quan Truong Hoang, Binh T. T. Pham, Jieun Bang, Chang Woo Koh, Ji Hee Kang, Jeong Hyun Lee, Xiaofeng Wu, Won Jong Rhee, Young Tag Ko, K. M. K. Swamy, Sungnam Park, JaeHong Park, Min Suk Shim, Juyoung Yoon

引用次数: 0

Mechanical Reinforced and Self-healing Hydrogels: Bioprinted Biomimetic Methacrylated Collagen Peptide-Xanthan Gum Constructs for Ligament Regeneration. 机械增强和自愈水凝胶：生物打印仿生甲基丙烯酸化胶原肽-黄原胶韧带再生结构。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-07-16 DOI: 10.1002/adhm.202502341

Hongjuan Weng, Monize Caiado Decarli, Lei He, Wen Chen, Sabine van Rijt, Katrien V Bernaerts, Lorenzo Moroni

{"title":"Mechanical Reinforced and Self-healing Hydrogels: Bioprinted Biomimetic Methacrylated Collagen Peptide-Xanthan Gum Constructs for Ligament Regeneration.","authors":"Hongjuan Weng, Monize Caiado Decarli, Lei He, Wen Chen, Sabine van Rijt, Katrien V Bernaerts, Lorenzo Moroni","doi":"10.1002/adhm.202502341","DOIUrl":"https://doi.org/10.1002/adhm.202502341","url":null,"abstract":"Collagen peptide (COP) is water soluble, bioactive, and tends to be a promising alternative to collagen for tissue regeneration. However, its low viscosity and lack of readily polymerizable groups hinder its bioprinting and limit its wide applications in tissue engineering. In this study, methacrylated collagen peptide-xanthan gum (COPMA-XG) bioinks with interpenetrating networks are developed for bioprinting stable constructs, followed by stem cell differentiation. First, self-healing COPMA hydrogels are developed with rapid UV-curing and tunable mechanical properties. To increase the printability and the mechanical properties of COPMA, XG is mixed to create a set of COPMA-XG bioinks. COPMA-XG hydrogels show self-healing properties, optimal printability, and stable morphology in the medium. The bioprinted human bone marrow mesenchymal stem cells (hMSCs) laden COPMA-XG constructs are biocompatible and bioactive, with increased production of extracellular matrix, collagen type I, and scleraxis over 28 days. Overall, bioprinted COPMA-XG constructs are versatile matrices to support hMSCs proliferation and differentiation with potential for ligament tissue engineering.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2502341"},"PeriodicalIF":10.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photocrosslinkable Kidney Decellularized Extracellular Matrix-Based Bioink for 3D Bioprinting. 用于3D生物打印的光交联肾脱细胞细胞外基质生物链接。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-07-16 DOI: 10.1002/adhm.202501616

Jaemyung Shin, Nima Tabatabaei Rezaei, Subin Choi, Zhangkang Li, Deok-Ho Kim, Keekyoung Kim

{"title":"Photocrosslinkable Kidney Decellularized Extracellular Matrix-Based Bioink for 3D Bioprinting.","authors":"Jaemyung Shin, Nima Tabatabaei Rezaei, Subin Choi, Zhangkang Li, Deok-Ho Kim, Keekyoung Kim","doi":"10.1002/adhm.202501616","DOIUrl":"https://doi.org/10.1002/adhm.202501616","url":null,"abstract":"Three-dimensional bioprinting has emerged as a promising strategy in tissue engineering, enabling the fabrication of biomimetic tissue constructs for regenerative medicine, disease modeling, and drug screening. A key challenge in this field is the development of organ-specific bioinks capable of recapitulating native microenvironments to support cell viability, proliferation, and tissue-specific maturation. In this study, a novel photocrosslinkable bioink derived from methacrylated decellularized porcine kidney extracellular matrix (KdMA) is reported. The decellularization process effectively removed cellular components while preserving key extracellular matrix constituents. The resulting KdMA bioink exhibited favorable rheological properties, including tunable stiffness and rapid photocuring kinetics, making it compatible with both digital light processing-based stereolithography and extrusion-based bioprinting platforms. Encapsulated human embryonic kidney cells maintained high viability and formed multicellular spheroids, demonstrating the bioink's cytocompatibility and structural support. Additionally, the KdMA bioink enabled stable multilayer bioprinting with preserved structural integrity and tunable mechanical properties. These results underscore the utility of KdMA as a kidney-specific bioink and its promise as a versatile platform for advancing renal tissue engineering and organoid maturation.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2501616"},"PeriodicalIF":10.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Encapsulation of Small Extracellular Vesicles into Selectively Disassemblable Shells of PEGylated Metal-Phenolic Networks (Adv. Healthcare Mater. 18/2025) 小的细胞外囊泡封装到聚乙二醇化金属-酚网络的选择性可拆卸外壳中（Adv. Healthcare Mater. 18/2025）

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-07-16 DOI: 10.1002/adhm.202570109

Chenyu Wang, Ailifeire Fulati, Kenta Kimura, Xianglan Li, Joseph J. Richardson, Mitsuru Naito, Kanjiro Miyata, Takanori Ichiki, Hirotaka Ejima

引用次数: 0

Triple-Tailored Analgesic Hydrogel System Targeting ADAM17 in Orofacial Inflammatory Pain. 靶向ADAM17的三重定制镇痛水凝胶系统治疗口腔面部炎症性疼痛。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-07-16 DOI: 10.1002/adhm.202501440

Yingyu Yi, Yuxuan Wu, Yanghong Xu, Zhengjie Han, Yuzhuo Wang, Jianwen Gong, Yubin Hu, Xinzhao Mai, Weizhe Sheng, Junting Li, Yujie Chen, Zhi Yang, Yaqin Zhu

{"title":"Triple-Tailored Analgesic Hydrogel System Targeting ADAM17 in Orofacial Inflammatory Pain.","authors":"Yingyu Yi, Yuxuan Wu, Yanghong Xu, Zhengjie Han, Yuzhuo Wang, Jianwen Gong, Yubin Hu, Xinzhao Mai, Weizhe Sheng, Junting Li, Yujie Chen, Zhi Yang, Yaqin Zhu","doi":"10.1002/adhm.202501440","DOIUrl":"https://doi.org/10.1002/adhm.202501440","url":null,"abstract":"Orofacial inflammatory pain (OFP) is challenging to manage due to its high incidence, complex anatomy, and multifactorial etiology. To address this, a three-step customized therapeutic system is proposed for prolonged pain relief and efficient local drug delivery. First, ADAM17 is identified as a novel therapeutic target for OFP, and find a small-molecule inhibitor, TAPI-1, which can effectively suppress ADAM17 activity. Subsequently, guided by the presence of an amine group on TAPI-1, an optimized hydrogel matrix is synthesized via Schiff-base bonding to enable stable encapsulation. The hydrogel, composed of hyaluronic acid derivatives carrying aldehyde (HAALD) and aminated gelatin (AGel), forms a scaffold that slows drug release. Second, for clinical application in orofacial tissue, unmodified hyaluronic acid (HA) and gelatin are incorporated to optimize the hydrogel's rheological properties for practicable injection. Third, to further prolong drug release, customized hollow mesoporous silica nanoparticles are added to trap a portion of TAPI-1, matching the drug's molecular diameter. This triple-tailored sustained-release hydrogel (HHGA hydrogel) maintains effective drug levels for 7 days, aligning with the pain phase and obviously relieving pain in mice. This \"drug-device\" innovation exemplifies the potential of personalized medicine in pain management and targeted therapies in translational medicine.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2501440"},"PeriodicalIF":10.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "Smart Dual-Sensor Wound Dressing for Monitoring Cutaneous Wounds". 修正“监测皮肤伤口的智能双传感器伤口敷料”。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-07-15 DOI: 10.1002/adhm.202502264

引用次数: 0