Advanced Healthcare Materials最新文献

{"title":"PLL-g-HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing","authors":"Jiewen Liao,&nbsp;Lin Gan,&nbsp;Li Lu,&nbsp;Lizhi Ouyang,&nbsp;Yuan Xiong,&nbsp;Fawwaz Al-Smadi,&nbsp;Guandong Dai,&nbsp;Mohammad-Ali Shahbazi,&nbsp;Bobin Mi,&nbsp;Mengfei Liu,&nbsp;Guohui Liu","doi":"10.1002/adhm.71700","DOIUrl":"10.1002/adhm.71700","url":null,"abstract":"<p>In this study, we demonstrate that during diabetic wound healing, interleukin-11 (IL-11) promotes the M1 polarization of macrophages, which subsequently triggers fibroblast senescence through the enhanced release of pro-inflammatory cytokines IL-1β and IL-6. Notably, Rhoifolin (Rho) effectively inhibits IL-11-induced M1 polarization, alleviates the secretion of IL-1β and IL-6, and concurrently promotes the release of choline, thereby mitigating fibroblast senescence. Based on these mechanistic findings, we constructed a targeted delivery system by loading Rho into mesoporous silica nanoparticles and coating them with macrophage membranes (M-Rho). The M-Rho were then incorporated into a poly(L-lysine)-grafted hyperbranched poly(amidoamine) (PLL-<i>g</i>-HPA) hydrogel to fabricate microneedles (Gel@M-Rho MN). This integrated system enables macrophage targeting, controlled drug release, favorable mechanical properties, and excellent biocompatibility. Moreover, the system exhibits potent reactive oxygen species (ROS)-scavenging activity and effectively inhibits the growth of <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>. In vivo animal studies confirmed that Gel@M-Rho MN significantly promotes M2 macrophage polarization, suppresses fibroblast senescence, and accelerates wound closure, angiogenesis, and collagen deposition. Collectively, this strategy, which modulates macrophage-fibroblast crosstalk, offers a multi-mechanistic synergistic therapeutic approach for diabetic wounds, holding substantial potential for clinical translation.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 38","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.71700","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148975103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translating Stroke Microenvironment Cues Into Materials Design: Intelligent Nanomaterials for Ischemic Stroke Therapy.","authors":"Jiajun Chen, Xiangqi Li, Jiali Deng, Ying Wang, Wei Feng, Lili Xia, Yu Chen, Bingcang Huang","doi":"10.1002/adhm.71843","DOIUrl":"https://doi.org/10.1002/adhm.71843","url":null,"abstract":"<p><p>Ischemic stroke (IS), caused by cerebral blood vessel occlusion, leads to ischemia, hypoxia, and irreversible brain tissue damage. Current treatments primarily rely on thrombolytic agents like alteplase, urokinase, and streptokinase for rapid reperfusion. However, these therapies are limited by narrow therapeutic windows, rapid clearance, poor blood-brain barrier (BBB) penetration, off-target effects, and the complex ischemic microenvironment. These have led to increased interest in nanomaterial-based platforms to improve the precision and efficacy of IS treatment. The IS microenvironment, characterized by oxidative stress, inflammation, ionic imbalance, acidosis, and BBB disruption, provides valuable cues for designing responsive nanomaterials. Nanomaterials engineered to respond to reactive oxygen species, pH, enzymes, light, ultrasound, or magnetic fields can enable targeted drug delivery, controlled release, and multi-modal interventions, enhancing therapeutic precision. This review discusses the IS microenvironment, limitations of traditional therapies, recent advances in intelligent nanomaterials for IS treatment, and the major barriers that currently limit clinical translation.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71843"},"PeriodicalIF":11.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macrophage-Targeted Cyclodextrin-Based Metal–Organic Frameworks Restore Redox–Efferocytosis Coupling to Promote Osteochondral Repair in Temporomandibular Joint Osteoarthritis","authors":"Jinyang Wang,&nbsp;Rongcheng Yu,&nbsp;Xinwei Zhou,&nbsp;Lei Huang,&nbsp;Xuanyi Li,&nbsp;Jiaxin Zou,&nbsp;Yi Deng,&nbsp;Fan Yang,&nbsp;Yang Yang","doi":"10.1002/adhm.71698","DOIUrl":"10.1002/adhm.71698","url":null,"abstract":"<div>\u0000 \u0000 <p>Temporomandibular joint osteoarthritis (TMJOA) causes cartilage degeneration and jaw dysfunction, yet current treatments mainly provide symptomatic relief rather than restore the diseased joint microenvironment. Although suppressing ROS-driven oxidative stress is essential for limiting inflammatory injury, impaired clearance of accumulated apoptotic cells may perpetuate local inflammation and hinder regenerative repair. Here, single-cell RNA sequencing identifies macrophages as the dominant immune population in TMJOA and reveals a redox-inflammatory phenotype accompanied by elevated apoptotic burden but insufficient macrophage efferocytosis, indicating a pathological mismatch between oxidative stress and efferocytic clearance. To correct this mismatch, this study develops MCP@CD-MOF, a macrophage-targeting cyclodextrin metal–organic framework nanoplatform co-loaded with curcumin and pioglitazone. In vitro, MCP@CD-MOF reduces macrophage ROS accumulation and inflammatory cytokine production, enhances efferocytic uptake of apoptotic chondrocytes, and promotes matrix-regenerative macrophage–chondrocyte crosstalk. In vivo, intra-articular administration of MCP@CD-MOF preferentially accumulates in synovial macrophages, alleviates local inflammation, reduces apoptotic burden, and preserves osteochondral architecture without detectable systemic toxicity. Mechanistically, MCP@CD-MOF coordinates the FOXO1–GPX4/ERK1/2–NOX2 redox network with the FAK–DOCK1–PAK1 efferocytosis pathway. Collectively, MCP@CD-MOF integrates redox regulation with efferocytosis-driven macrophage reprogramming, providing a disease-modifying biomaterial strategy that couples inflammation resolution with osteochondral repair in TMJOA.</p>\u0000 </div>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 38","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stabilizing and Programming Gallium in Hydrogels: From Iron-Mimetic Bioactivity to Localized Therapeutic Function","authors":"Boao Xie,&nbsp;Xiaoke Gao,&nbsp;Lisha Wang,&nbsp;Chenxuan Wang,&nbsp;Yuexin Chen","doi":"10.1002/adhm.71726","DOIUrl":"10.1002/adhm.71726","url":null,"abstract":"<div>\u0000 \u0000 <p>Gallium (Ga) is an iron-mimetic metal with broad-spectrum antimicrobial activity and emerging potential in bone regeneration and localized cancer therapy. However, its biomedical translation is limited by unfavorable pharmacokinetics, systemic exposure, and hydrolytic instability of free Ga³⁺ under physiological conditions. Hydrogels offer a versatile strategy by stabilizing gallium species, enhancing local retention, regulating release, and providing tissue-compatible interfaces and microenvironmental modulation. This review focuses on how hydrogel design can stabilize different gallium species, control their local availability, and improve therapeutic performance across distinct pathological microenvironments. We summarize gallium bioactivity and speciation, classify gallium-containing hydrogels according to gallium incorporation and network interactions, and analyze how network architecture, coordination chemistry, degradation, and external stimuli govern retention and release. Emerging applications include infected wound and biofilm treatment, bone repair, localized cancer therapy, and other site-specific interventions. We further discuss iron competition, immune regulation, cytotoxicity, liquid-metal stability, and translational barriers, and outline directions for mechanism-guided and quantitatively standardized gallium-hydrogel design.</p>\u0000 </div>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 38","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148987259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macrophage-Fibroblast Crosstalk Governs Tumor Mechanics, as Revealed by Spatiotemporal Force Mapping in 3D Spheroids.","authors":"Kunal P Pednekar, Daan Vorselen, Jai Prakash","doi":"10.1002/adhm.71844","DOIUrl":"https://doi.org/10.1002/adhm.71844","url":null,"abstract":"<p><p>Understanding how stromal and immune cells regulate tumor mechanics is essential for deciphering cancer progression and therapy resistance. This study presents a microparticle-based traction force microscopy strategy for in situ quantification of compressive forces within 3D tumor spheroids. Multicellular spheroids composed of tumor cells (T), fibroblasts (F), and macrophages (M) were generated to mimic the tumor microenvironment and to understand the contribution of fibroblast-macrophage crosstalk in tumor mechanobiology. Tri-culture spheroids exhibited the highest proliferative capacity compared to mono- and bi-cultured tumor spheroids. Gene expression profiling indicated strong fibroblast activation, extracellular matrix remodeling, and M2-like macrophage polarization, highlighting a pro-tumoral phenotype. Incorporation of deformable hydrogel microparticles allowed direct mapping of local compressive and indirect quantification of anisotropic stresses. This mapping revealed fibroblasts are the principal source of force generation with the spheroids. Notably, macrophages amplified bulk and anisotropic stresses over two-fold through paracrine activation of fibroblasts. Spatial mapping showed pressure gradients from the core to the periphery, while temporal analyses demonstrated a progressive increase in mechanical stresses with spheroid growth. Together, these findings reveal a surprising governing of intratumoral mechanics by macrophage-fibroblast interactions and demonstrate the potential of microparticle-based 3D force mapping within complex tumor environments.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71844"},"PeriodicalIF":11.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-Assembled Aptamer-Derived PROTAC Enables Efficient Cellular Internalization for Intracellular Sclerostin Degradation and Triple-Negative Breast Cancer Therapy","authors":"Hang Luo,&nbsp;Zefeng Chen,&nbsp;Yufei Pan,&nbsp;Meiheng Sun,&nbsp;Yihao Zhang,&nbsp;Huarui Zhang,&nbsp;Hewen Jiang,&nbsp;Xiaohui Tao,&nbsp;Yingchao Wu,&nbsp;Kuikun Yang,&nbsp;Xin Yang,&nbsp;Shijian Ding,&nbsp;Luyao Wang,&nbsp;Yuanyuan Yu,&nbsp;Zhiyu Wang,&nbsp;Yixin He,&nbsp;Qianjun Chen,&nbsp;Sifan Yu,&nbsp;Yuan Ma,&nbsp;Baoting Zhang,&nbsp;Ge Zhang","doi":"10.1002/adhm.71723","DOIUrl":"10.1002/adhm.71723","url":null,"abstract":"<div>\u0000 \u0000 <p>Comprising an aptamer for protein of interest (POI) recognition, a linker, and an E3 ligand, aptamer-derived PROTAC enables precise intracellular POI degradation via ubiquitin-proteasome system. Due to hydrophilic polyanionic backbone, their efficacy was fundamentally constrained by inefficient cellular internalization. Here, we engineered a self-assembled aptamer-derived PROTAC (SADP) featuring a dual-hydrophobic module composed of an alkyl linker and a separate fatty acid. The alkyl linker could modulate the spatial arrangement between the aptamer and E3 ligand while also synergize with the fatty acid to drive formation of SADP nanomicelles for cellular internalization enhancement. As a proof of concept, SADP (Apt-F-10-V) was screened and achieved approximately five-fold higher internalization efficiency than conventional aptamer-derived PROTAC, resulting in potent intracellular sclerostin degradation (DC₅₀ = 76.8 nM, Dmax = 82%) in triple-negative breast cancer (TNBC) cells. Mechanistically, Apt-F-10-V could be internalized via clathrin-mediated endocytosis, followed by lysosomal disassembly and escape into the cytoplasm. The liberated monomers could induce a sclerostin/PROTAC/VHL ligase ternary complex for intracellular sclerostin degradation. Importantly, Apt-F-10-V demonstrated tumor accumulation and robust tumor suppression in both TNBC cell-derived and patient-derived xenograft models. This study presents that cooperative micellization of aptamer-derived PROTAC could overcome the cellular internalization barrier, enabling potent intracellular sclerostin degradation and TNBC therapy.</p>\u0000 </div>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 38","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering a Multifunctional Sprayable Curcumin-Modified Polyitaconate-Based Hydrogel to Accelerate Methicillin-Resistant Staphylococcus aureus-Infected Wound Healing","authors":"Min Wang,&nbsp;Guoqiang Wang,&nbsp;Sihua Li,&nbsp;Jiachen Wang,&nbsp;Jing Tian,&nbsp;Yanzi Zhao,&nbsp;Hao Yang","doi":"10.1002/adhm.71699","DOIUrl":"10.1002/adhm.71699","url":null,"abstract":"<div>\u0000 \u0000 <p>Hydrogel dressings that can simultaneously curb infection and dampen inflammation are particularly attractive for accelerating multidrug-resistant bacteria-infected wound healing. However, clinical translation of many reported hydrogels is often constrained by multi-component formulations, complicated preparation procedures, and insufficient sprayability, which limit conformal coverage on irregular wound beds. Polyitaconate possesses intrinsic antibacterial and anti-inflammatory activities, yet its weak antioxidative properties and lack of thermogelling properties limit its utility in infected wound healing. In this study, we develop a curcumin-modified polyitaconate-based hydrogel (FPIC) that integrates antibacterial, anti-inflammatory, and antioxidant properties. FPIC hydrogel exhibits thermoresponsive gelation, injectability, sprayability, and shear-thinning properties, allowing convenient close contact with complex wound geometries. FPIC hydrogel inhibits bacterial growth, moderates excessive inflammatory responses, and eliminates reactive oxygen species while promoting angiogenesis, thereby facilitating the shift from the inflammatory phase to the proliferative phase of healing. Moreover, FPIC hydrogel enhances collagen deposition, speeds re-epithelialization, and supports balanced tissue remodeling, enabling improved skin regeneration with a lower propensity for fibrosis. These findings establish FPIC hydrogel as a multifunctional and highly bioactive polyitaconate-based hydrogel dressing with strong promise for treating infection- and inflammation-associated wounds and advancing toward clinical use.</p>\u0000 </div>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 38","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Coacervates Made of Elastin-Like Polypeptides Fused with Melanocyte-Stimulating Hormone and Monocyte Chemoattractant Protein Enhance Skin Wound Healing in Spinal Cord-Injured Mice”","authors":"","doi":"10.1002/adhm.71518","DOIUrl":"10.1002/adhm.71518","url":null,"abstract":"&lt;p&gt;S. Kumar, D. Patel, G. Manjunath, et al., “Coacervates Made of Elastin-Like Polypeptides Fused with Melanocyte-Stimulating Hormone and Monocyte Chemoattractant Protein Enhance Skin Wound Healing in Spinal Cord-Injured Mice,” Advanced Healthcare Materials 15, no. 20 (2026): e03910, https://doi.org/10.1002/adhm.202503910.&lt;/p&gt;&lt;p&gt;In the paragraph of the “Results” Section 2.4.3, the text “Increasing concentrations (0–4 µm) of LPS led to a significant reduction in fibroblast migration and wound recovery. Cells that were treated with 4 µm LPS exhibited a dramatic decrease in wound closure percentage compared to the control group (0 µm) at all time points (&lt;i&gt;p&lt;/i&gt; &lt; 0.0001). These results suggest that LPS negatively impacts cell migration, likely due to its pro-inflammatory characteristics (Figure 5a). Using this system, we evaluated the anti-inflammatory properties of MSH-ELP and assessed the ability of MSH-ELP nanoparticles to mitigate LPS-induced inhibition of fibroblast migration. Thus, we tested wound closure rates in the presence of 4 µm of LPS treated with 3 µm of MSH-ELP (Figure 5b).” was incorrect. This should have read: “Increasing concentrations (0–20 µg/mL) of LPS led to a significant reduction in fibroblast migration and wound recovery. Cells that were treated with 20 µg/mL LPS exhibited a dramatic decrease in wound closure percentage compared to the control group (0 µg/mL) at all time points (&lt;i&gt;p&lt;/i&gt; &lt; 0.0001). These results suggest that LPS negatively impacts cell migration, likely due to its pro-inflammatory characteristics (Figure 5a). Using this system, we evaluated the anti-inflammatory properties of MSH-ELP and assessed the ability of MSH-ELP nanoparticles to mitigate LPS-induced inhibition of fibroblast migration. Thus, we tested wound closure rates in the presence of 20 µg/mL of LPS treated with 3 µm of MSH-ELP (Figure 5b).”&lt;/p&gt;&lt;p&gt;“FIGURE 5 was incorrect and should be replaced with the corrected Figure 5 as shown below.”&lt;/p&gt;&lt;p&gt;&lt;/p&gt;&lt;p&gt;In the &lt;i&gt;Figure 5&lt;/i&gt; caption, the text “(a) Effect of varying doses of LPS (0, 0.5, 1, 2, and 4 µm) on cell migration up to 3 days in the scratch wound assay. Black asterisks mean differences between 0 µm and all other groups, while red asterisks mean 0 vs. 4 µm. Cell migration was significantly inhibited at 4 µm LPS when added once at day 0. **** p &lt; 0.0001; No LPS vs. LPS (0.5–4 µm). (b) Effect of MSH-ELP nanoparticles (3 µm) on cell migration under the influence of LPS (4 µm).” was incorrect. This should have read: “(a) Effect of varying doses of LPS (0, 2.5, 5, 10, and 20 µg/mL) on cell migration up to 3 days in the scratch wound assay. Black asterisks mean differences between 0 µg/mL and all other groups, while red asterisks mean 0 µg/mL versus 20 µg/mL. Cell migration was significantly inhibited at 20 µg/mL LPS when added once at day 0. **** &lt;i&gt;p&lt;/i&gt;&lt; 0.0001; No LPS versus LPS (2.5-20 µg/mL). (b) Effect of MSH-ELP nanoparticles (3 µM) on cell migration under the influence of LPS","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 38","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.71518","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148617495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Directing Valvular Interstitial Cell Myofibroblast-Like Differentiation in a Hybrid Hydrogel Platform\".","authors":"","doi":"10.1002/adhm.71796","DOIUrl":"https://doi.org/10.1002/adhm.71796","url":null,"abstract":"","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71796"},"PeriodicalIF":11.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Standardized Chewable Conductive Hydrogel Sensor for Direct Monitoring of Masticatory Dynamics.","authors":"Xiaoxuan Xue, Zhan Gao, Jun Wang, Yizhang Yang, Kewei Zhang, Chao Yang","doi":"10.1002/adhm.71865","DOIUrl":"https://doi.org/10.1002/adhm.71865","url":null,"abstract":"<p><p>Chewing is a fundamental orofacial function closely related to nutrition, digestion, and quality of life, yet current assessment methods generally rely on indirect signals or endpoint measurements and provide limited process-level information. Here, a hydroxypropyl cellulose (HPC)/polyacrylamide (PAM) conductive hydrogel is developed as a standardized chewable sensor that integrates the test substrate with force-to-electrical signal transduction, enabling direct monitoring of masticatory dynamics. The sensor captures chewing frequency, relative force response, chewing duration, relative force response variability, and rhythm variability during standardized tests. Using predefined chewing-state labels, these features were integrated into a classification framework, with KNN achieving 98.0% accuracy in recording-level cross-validation and 76.7% in nested leave-one-participant-out validation, providing an initial assessment of generalizability to unseen participants. The hydrogel exhibits a compressive strength of 2.3 MPa, toughness of 287 kJ m^- ³, a response time of 150 ms, recovery within 173 ms, and less than 3% signal attenuation over 150 cycles. Polydimethylsiloxane (PDMS) encapsulation supports stable intraoral operation and biocompatibility. This work establishes a proof-of-concept platform for standardized acquisition and analysis of process-resolved chewing data, offering a route toward objective, data-driven assessment of masticatory function and, with larger population datasets, personalized oral rehabilitation and healthcare decision-making.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71865"},"PeriodicalIF":11.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}