Advanced Healthcare Materials最新文献_第3页

Multi-Signal Responsive Allosteric Nanozymes for Spatiotemporally Confined Ferroptosis via Tumor-Intrinsic Stress Amplification. 多信号响应变构纳米酶对时空受限铁下垂的影响。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2026-05-06 DOI: 10.1002/adhm.202505562

Jing Yang, Yixin Wen, Zhennian Liu, Xiaoxue Xie, Ruishu Xu, Fan Li, Yifan Xing, Haiyan Li, Houen Zou, Keqin Deng, Zhijun Zhou, Haowen Huang

{"title":"Multi-Signal Responsive Allosteric Nanozymes for Spatiotemporally Confined Ferroptosis via Tumor-Intrinsic Stress Amplification.","authors":"Jing Yang, Yixin Wen, Zhennian Liu, Xiaoxue Xie, Ruishu Xu, Fan Li, Yifan Xing, Haiyan Li, Houen Zou, Keqin Deng, Zhijun Zhou, Haowen Huang","doi":"10.1002/adhm.202505562","DOIUrl":"https://doi.org/10.1002/adhm.202505562","url":null,"abstract":"Ferroptosis, an iron-dependent form of regulated cell death, holds great promise for eliminating therapy-resistant tumors, but clinical translation has been limited by poor spatiotemporal selectivity and the lack of dynamic control over catalytic activity. Here we present a multi-signal responsive allosteric nanozyme platform that exploits tumor-intrinsic stress amplification (TISA) to achieve spatiotemporally confined ferroptosis. The design integrates three microenvironmental cues-reactive oxygen species (ROS), acidic pH, and elevated glutathione (GSH)-as cooperative allosteric effectors: ROS primes the catalyst, acidic pH accelerates peroxidase-like (POD-like) activity, and intracellular GSH acts as a reversible brake to self-limit activity post-activation. Only upon convergence of all three signals does the nanozyme switch from an off-state to a high-turnover state, triggering localized lipid peroxidation and bypassing systemic oxidative damage. Across orthotopic and metastatic tumor models, TISA nanozymes selectively amplified ferroptotic stress in tumor tissue, overcame antioxidant buffering, and suppressed tumor growth with minimal off-target toxicity. This multi-layered gating and confinement strategy establishes a blueprint for precision ferroptosis nanomedicine and offers a generalizable approach to harness complex tumor microenvironment signals for safe and effective catalytic therapy.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e05562"},"PeriodicalIF":9.6,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional and Self-Healing Oxidized Bacterial Nanocellulose-Based Composite Hydrogels with pH-Switchable Cascade Enzyme Catalytic Activity for Accelerating Diabetic Wound Healing. 具有ph可切换级联酶催化活性的多功能自修复氧化细菌纳米纤维素复合水凝胶加速糖尿病伤口愈合。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2026-05-06 DOI: 10.1002/adhm.202505377

Yanyan Xie, Dongmei Li, Yan Xi, Mengna Zhang, Weiwei Zhu, Xiaozhi Liu, Yingjie Du, Zhilei Tan, Tengfei Wang, Chunlong Liu, Cheng Zhong

{"title":"Multifunctional and Self-Healing Oxidized Bacterial Nanocellulose-Based Composite Hydrogels with pH-Switchable Cascade Enzyme Catalytic Activity for Accelerating Diabetic Wound Healing.","authors":"Yanyan Xie, Dongmei Li, Yan Xi, Mengna Zhang, Weiwei Zhu, Xiaozhi Liu, Yingjie Du, Zhilei Tan, Tengfei Wang, Chunlong Liu, Cheng Zhong","doi":"10.1002/adhm.202505377","DOIUrl":"https://doi.org/10.1002/adhm.202505377","url":null,"abstract":"Effective healing of diabetic wounds remains a major clinical challenge due to persistent hyperglycemia, bacterial infections, and hypoxia. In this study, a multifunctional self-healing hydrogel by embedding Fe3O4 nanoparticles (NPs) immobilized with glucose oxidase (Fe3O4/GOD) into a dynamic Schiff base-crosslinked hydrogel matrix of composed of oxidized bacterial nanocellulose (OBNC-D), carboxymethyl chitosan (CMC), and ε-poly-L-lysine (ε-PL) is developed. The resulting Fe3O4/GOD@H hydrogel exhibited excellent injectability, mechanical robustness, and self-healing capability, attributed to dynamic imine bond formation. Functionally, the embedded Fe3O4/GOD nanozyme enabled glucose-responsive cascade reactions, generating hydroxyl radicals (·OH) under mildly acidic conditions for potent antibacterial activity, and producing oxygen under neutral conditions to alleviate local hypoxia. In vitro experiments confirmed efficient ·OH generation, sustained oxygen release, and significant antibacterial efficacy against Staphylococcus aureus and Escherichia coli. The hydrogel also exhibited good hemocompatibility and cytocompatibility, particularly at optimized nanozyme concentrations. In a diabetic rat model, Fe3O4/GOD@H markedly accelerated wound closure and achieved complete re-epithelialization within 14 days, with minimal tissue toxicity. This intelligently responsive hydrogel provides a promising strategy for diabetic wound treatment by integrating glucose regulation, antibacterial action, and oxygen delivery to overcome multiple healing barriers.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e05377"},"PeriodicalIF":9.6,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomimetic Wavy-Crimped Porous Structure Enhances Tendon Attachment Reconstruction via Integrin-FAK/Src-MAPK Signaling Axis. 仿生波浪卷曲多孔结构通过Integrin-FAK/Src-MAPK信号轴增强肌腱附着重建。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2026-05-06 DOI: 10.1002/adhm.202504509

Jinbo Zhang, Hao Chen, Xingzhen Li, Aobo Zhang, Yang Liu, Zhuoxuan Li, Zhaowei Zhang, Bingpeng Chen, Jincheng Wang, Xue Zhao, Qing Han

{"title":"Biomimetic Wavy-Crimped Porous Structure Enhances Tendon Attachment Reconstruction via Integrin-FAK/Src-MAPK Signaling Axis.","authors":"Jinbo Zhang, Hao Chen, Xingzhen Li, Aobo Zhang, Yang Liu, Zhuoxuan Li, Zhaowei Zhang, Bingpeng Chen, Jincheng Wang, Xue Zhao, Qing Han","doi":"10.1002/adhm.202504509","DOIUrl":"https://doi.org/10.1002/adhm.202504509","url":null,"abstract":"Large bone defects often necessitate suturing tendons to the surfaces of porous prostheses to restore joint function. However, current porous structures frequently trigger fibrotic healing at the tendon-prosthesis interface, leading to disorganized tissue and insufficient mechanical strength, which critically limits long-term stability and recovery. In native tendons, collagen fibers exhibit a wavy-crimped microstructure that guides tendon-derived stem cells (TDSCs) alignment and promotes tenogenic differentiation. Inspired by this architecture, we developed a biomimetic tendon wavy-crimped porous titanium scaffold (BT). In a rabbit patellar tendon attachment reconstruction model, BT scaffolds promoted the ordered arrangement of interfacial tissue, reduced scar formation, and significantly strengthened tendon attachment. In vitro, BT guided TDSCs alignment, enhanced expression of tenogenic markers (COL I, SCX and TNMD), suppressed the fibrotic marker α-SMA, and upregulated the antifibrotic factor TGF-β3, collectively supporting reduced fibrosis and improved stability. Transcriptomic analysis revealed that BT activated the integrin-FAK/Src-MAPK signaling axis, driving tenogenic differentiation while suppressing fibrogenesis, thereby elucidating the molecular mechanism of enhanced tendon-prosthesis integration. Our results demonstrate that BT scaffolds effectively overcome fibrotic tendon-prosthesis interface healing and provide a promising strategy to address the long-standing challenge of insufficient interfacial mechanics in tendon-prosthesis reconstruction.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e04509"},"PeriodicalIF":9.6,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147830948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physically Inactivated Tumor Organoids Enable Rapid and Personalized Enrichment of Cytotoxic T Cells for Solid Tumor Immunotherapy. 物理灭活的肿瘤类器官能够快速和个性化地富集细胞毒性T细胞用于实体瘤免疫治疗。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2026-05-06 DOI: 10.1002/adhm.202503992

Yu Zhang, Haoran Zhao, Junhong Zeng, Zitian Wang, Xiaoyong Dai, Yongde Cai, Ruirui Qiao, Qingwen Wang, Peter E Lobie, Shaohua Ma

{"title":"Physically Inactivated Tumor Organoids Enable Rapid and Personalized Enrichment of Cytotoxic T Cells for Solid Tumor Immunotherapy.","authors":"Yu Zhang, Haoran Zhao, Junhong Zeng, Zitian Wang, Xiaoyong Dai, Yongde Cai, Ruirui Qiao, Qingwen Wang, Peter E Lobie, Shaohua Ma","doi":"10.1002/adhm.202503992","DOIUrl":"https://doi.org/10.1002/adhm.202503992","url":null,"abstract":"Adoptive T cell therapy holds great promise for the treatment of solid tumors but remains constrained by tumor heterogeneity, inefficient neoantigen targeting, and the complexity of T cell manufacturing. Here, we present a patient-specific, broadly applicable platform using physically inactivated tumor organoids (PIOs) to generate tumor-specific cytotoxic T cells ex vivo. Derived from droplet-engineered tumor organoids (DEOs), PIOs preserve the full antigenic repertoire of the patient's tumor without requiring synthetic peptides, antigen-presenting cells, or neoantigen prediction. Using matched tumor tissue and PBMCs from colorectal and liver cancer patients, we show that PIOs activate and expand tumor-specific T cells with enhanced infiltration, selective cytotoxicity, and robust secretion of IFN-γ and IL-2. Multi-round PIO stimulation achieves 80-400-fold expansion of CD8+CD137+ T cells within two weeks. Transcriptomic and epigenetic profiling suggest that PIOs modulate T cell programs linked to migration and persistence. This work redefines tumor organoids as immunotherapeutic materials and establishes a rapid, cost-effective platform for personalized T cell manufacturing. Our findings provide a new translational route for adoptive cell therapy in solid tumors using patient-derived materials.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e03992"},"PeriodicalIF":9.6,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chamber-Specific Decellularized Extracellular Matrices Differentially Modulate Cardiomyocyte Subtypes to Drive Engineered Heart Tissue Development and Function. 室特异性脱细胞细胞外基质差异调节心肌细胞亚型驱动工程心脏组织发育和功能。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2026-05-06 DOI: 10.1002/adhm.202503802

Dong Gyu Hwang, Myungji Kim, Hwanyong Choi, Jinseon Park, Minji Kim, Donghwan Kim, Bo Ram Lee, Jinah Jang

{"title":"Chamber-Specific Decellularized Extracellular Matrices Differentially Modulate Cardiomyocyte Subtypes to Drive Engineered Heart Tissue Development and Function.","authors":"Dong Gyu Hwang, Myungji Kim, Hwanyong Choi, Jinseon Park, Minji Kim, Donghwan Kim, Bo Ram Lee, Jinah Jang","doi":"10.1002/adhm.202503802","DOIUrl":"https://doi.org/10.1002/adhm.202503802","url":null,"abstract":"Decellularized extracellular matrix (dECM) preserves native biochemical and biophysical cues and serves as a functional biomaterial for engineered tissue development. While tissue-specific extracellular matrix (ECM) has been widely studied, regional variation within the same organ remains poorly understood. Here, we investigate chamber-specific roles of ventricular (vtdECM) and atrial (atdECM) dECMs in engineered heart tissue (EHT) formation using induced pluripotent stem cell-derived cardiomyocyte (CM) subtypes. Proteomic analysis revealed distinct compositional profiles, with vtdECM enriched in ventricular development-related proteins and atdECM enriched in structural organization-related proteins. Ventricular CMs exhibited enhanced maturation and function in vtdECM, whereas atrial CMs showed limited responsiveness to ECM composition despite transcriptome-level differences. Encapsulation timing further modulated these effects, with early encapsulation promoting structural maturation and late encapsulation enhancing calcium handling. These findings demonstrate that chamber-specific ECM composition and developmental timing cooperatively regulate subtype-specific CM maturation, providing a framework for designing physiologically relevant EHTs.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e03802"},"PeriodicalIF":9.6,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147830955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucose Oxidase-Powered Ferrium MOFs for Self-Amplifying Fenton Catalysis and Photothermal Therapy. 葡萄糖氧化酶驱动的自扩增Fenton催化和光热治疗的铁mof。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2026-05-06 DOI: 10.1002/adhm.71190

Shengnan Xin, Zhe Liu, Jinghan Wang, Yanhua Wu, Ziyi Jiang, Jielin Cui, Dandan Wang, Peiwei Gong

{"title":"Glucose Oxidase-Powered Ferrium MOFs for Self-Amplifying Fenton Catalysis and Photothermal Therapy.","authors":"Shengnan Xin, Zhe Liu, Jinghan Wang, Yanhua Wu, Ziyi Jiang, Jielin Cui, Dandan Wang, Peiwei Gong","doi":"10.1002/adhm.71190","DOIUrl":"https://doi.org/10.1002/adhm.71190","url":null,"abstract":"Traditional metal-organic frameworks (MOFs) suffer from limited responsiveness to the complex tumor microenvironment, systemic toxicity from non-specific distribution, and compromised Fenton-like efficiency due to antioxidants. To address these, we propose a multi-modal synergistic strategy to functionalize MOFs and achieve chemodynamic and photothermal synergy without chemotherapeutics. A replacement MOFs system (FHMGA) integrated with hyaluronic acid, glucose oxidase, and gold nanoparticles is designed based on CD44 receptor recognition. In the acidic TME, FHMGA degrades and is reduced by overexpressed glutathione to Fe2+ and Mn2+ for further reaction with endogenous H2O2 via Fenton-like reactions to generate ·OH and induce oxidative stress. Under near-infrared irradiation, gold nanoparticles exhibit high photothermal conversion efficiency, triggering local hyperthermia for thermal ablation. Simultaneously, heat enhances glucose oxidase-powered catalysis, which catalyzes glucose oxidation in cancer cells to disrupt energy metabolism and produce additional H2O2, further boosting Fenton-like reactions. Our results demonstrate that FHMGA exhibits significant anti-tumor efficacy with minimal systemic toxicity. The triple synergy of oxidative damage from chemodynamic therapy, thermal ablation from photothermal therapy, and metabolic disruption via glucose oxidase significantly inhibits cancer cell growth by overcoming antioxidant-mediated limitations. Self-amplifying Fenton catalysis, while responsive degradation reduces systemic toxicity. This work advances precise cancer therapy by establishing a chemotherapy-free, multi-responsive synergistic system, addressing critical bottlenecks of ferrium-based MOFs and providing a safer, more effective strategy for tumor-specific treatment.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71190"},"PeriodicalIF":9.6,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147830985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeted Gut Delivery of Zn, Cu, and Mn Nanominerals Alleviates Oxidative Stress by Activating Endogenous SOD Enzymes. 通过激活内源性SOD酶，肠道靶向递送Zn、Cu和Mn纳米矿物减轻氧化应激。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2026-05-06 DOI: 10.1002/adhm.71209

Stuti Bhagat, Sandeep Kushwaha, Sanjay Singh

{"title":"Targeted Gut Delivery of Zn, Cu, and Mn Nanominerals Alleviates Oxidative Stress by Activating Endogenous SOD Enzymes.","authors":"Stuti Bhagat, Sandeep Kushwaha, Sanjay Singh","doi":"10.1002/adhm.71209","DOIUrl":"https://doi.org/10.1002/adhm.71209","url":null,"abstract":"Trace minerals such as Zn, Cu, and Mn are essential for maintaining cellular redox balance as cofactors of key antioxidant enzymes, including SOD1 and SOD2. However, their oral supplementation is often limited by poor stability in the acidic gastric environment and low intestinal absorption. Here, we report the synthesis of methionine-coated-ZnO (Met-ZnO), ascorbic acid-coated Cu2O (AA-Cu2O), and dextran-coated MnO2 (Dex-MnO2) nanominerals, followed by encapsulation into pH-responsive microcapsules (NMs-MCap) for targeted intestinal delivery. The nanomineral mixture demonstrated strong antioxidant activity at physiological pH by scavenging superoxide radicals, hydrogen peroxide, and ABTS•+ radicals. In intestinal epithelial (IEC-6) cells, nanominerals significantly alleviated BSO-induced oxidative stress, reducing apoptosis, necrosis, and intracellular ROS accumulation. Oral administration of NMs-MCap in Zn, Cu, and Mn-deficient rats elevated mineral levels in blood and liver, mitigated BSO-induced oxidative damage, reduced lipid peroxidation and pro-inflammatory cytokines, and preserved tissue architecture. Importantly, oral supplementation restored SOD1 and SOD2 expression in key organs, supporting enhanced endogenous antioxidant defense. Metagenomic analysis revealed that mineral deficiency, combined with oxidative stress, caused gut dysbiosis, reducing beneficial taxa and enriching opportunistic ones. Nanomineral supplementation restored microbial balance, increased SCFA-producing bacteria, and improved antioxidant and metal-handling functions, establishing NMs-MCap as a safe, targeted antioxidant strategy supporting host health.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71209"},"PeriodicalIF":9.6,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reinforced Bacterial Cellulose/GelMA-HAMA Bionic Cartilage Hydrogel with Spatiotemporal Delivery of Exosomes and BMSCs for Temporomandibular Joint Disc Regeneration. 增强细菌纤维素/GelMA-HAMA仿生软骨水凝胶时空递送外泌体和骨髓间充质干细胞用于颞下颌关节盘再生。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2026-05-06 DOI: 10.1002/adhm.202503929

Jie Lu, Wuzhe Fan, Xiaohui Wang, Wentong Gao, Ming Jiang, Weihu Yang, Kaiyong Cai, Jie Xu

{"title":"Reinforced Bacterial Cellulose/GelMA-HAMA Bionic Cartilage Hydrogel with Spatiotemporal Delivery of Exosomes and BMSCs for Temporomandibular Joint Disc Regeneration.","authors":"Jie Lu, Wuzhe Fan, Xiaohui Wang, Wentong Gao, Ming Jiang, Weihu Yang, Kaiyong Cai, Jie Xu","doi":"10.1002/adhm.202503929","DOIUrl":"https://doi.org/10.1002/adhm.202503929","url":null,"abstract":"Cartilage regeneration, especially of the temporomandibular joint (TMJ) disc critical for chewing and speech, remains challenging. Key hurdles include its avascular, low-cell structure (impeding repair cell migration) and persistent post-injury compressive/shear stresses (damaging tissue and disrupting new formation). This study designed a sandwich composite hydrogel: GelMA/HAMA loaded with BMSCs, combined with a PVA-bacterial cellulose membrane carrying chondrocyte-derived exosomes. The membrane provides mechanical support and slowly releases exosomes to regulate BMSC proliferation/differentiation. Biomechanical analysis showed reduced stress concentration at perforation edges, protecting regeneration. In vitro experiments confirmed upregulated cartilage matrix genes (e.g., COL1A1, ACAN) in BMSCs. Implantation in a rabbit TMJ disc perforation model for eight weeks led to new cartilage-like tissue and successful repair. This system, optimizing mechanical microenvironment, regulating stem cell fate, and promoting matrix regeneration, offers a novel strategy for functional TMJ disc repair.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e03929"},"PeriodicalIF":9.6,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Supramolecular Engineering of Fluid Pressure in Filamentous Hybrid Double Network Hydrogels for 3D Chondrocyte Culture. 用于三维软骨细胞培养的丝状杂交双网水凝胶流体压力的超分子工程。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2026-05-06 DOI: 10.1002/adhm.202505238

Ciqing Tong, Ying Chen, Merel L Janssen, Isabel Sariol, Joeri A J Wondergem, Marijn van den Brink, Mertcan Özel, Rob G H H Nelissen, Ingrid Meulenbelt, Doris Heinrich, Yolande F M Ramos, Roxanne E Kieltyka

{"title":"Supramolecular Engineering of Fluid Pressure in Filamentous Hybrid Double Network Hydrogels for 3D Chondrocyte Culture.","authors":"Ciqing Tong, Ying Chen, Merel L Janssen, Isabel Sariol, Joeri A J Wondergem, Marijn van den Brink, Mertcan Özel, Rob G H H Nelissen, Ingrid Meulenbelt, Doris Heinrich, Yolande F M Ramos, Roxanne E Kieltyka","doi":"10.1002/adhm.202505238","DOIUrl":"https://doi.org/10.1002/adhm.202505238","url":null,"abstract":"Filamentous supramolecular polymers provide a modular synthetic platform that can emulate various extracellular matrix biopolymers in their structure and function. However, hydrogels based on their entangled one-dimensional nanostructures are mechanically weak and challenged in replicating the properties of native tissues that surmount cyclic compressive loads. Inspired by the structural features of load-bearing tissues such as cartilage that consist of water-rich and interconnected biopolymer networks with distinct features, we explore the in situ photopolymerization of a secondary covalent network within a filamentous supramolecular material. The resulting connectable hybrid double network hydrogels show biomimetic cartilage-like mechanical properties under dynamic loads, such as hydrostatic pressure generation and stress relaxation. We further exploit the biocompatible dithiolane-ene light-mediated crosslinking reaction to culture human primary articular chondrocytes in 3D within the materials under cyclic compressive loads. Their loading leads to significantly increased production of cartilaginous matrix proteins, sulfated-glycosaminoglycans, fibronectin I and collagen II, particularly in the photocrosslinked domains. The enclosed hybrid supramolecular and covalent double network strategy with biocompatible light-mediated crosslinking paves the way to expand the application space of filamentous supramolecular materials in 3D cell culture, providing facile access to compressive mechanical features such as hydrostatic pressure and stress relaxation essential for load-bearing cell types.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e05238"},"PeriodicalIF":9.6,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RETRACTION: Bivalent Gadolinium Ions Forming Injectable Hydrogels for Simultaneous In Situ Vaccination Therapy and Imaging of Soft Tissue Sarcoma. 缩回：二价钆离子形成可注射水凝胶用于软组织肉瘤的同时原位疫苗治疗和成像。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2026-05-06 DOI: 10.1002/adhm.71200

{"title":"RETRACTION: Bivalent Gadolinium Ions Forming Injectable Hydrogels for Simultaneous In Situ Vaccination Therapy and Imaging of Soft Tissue Sarcoma.","authors":"","doi":"10.1002/adhm.71200","DOIUrl":"https://doi.org/10.1002/adhm.71200","url":null,"abstract":"Retraction: C. Wang, Y. Jing, W. Yu, J. Gu, Z. Wei, A. Chen, Y.-T. Yen, X. He, L. Cen, A. Chen, X. Song, Y. Wu, L. Yu, G. Tao, B. Liu, S. Wang, B. Xue, and R. Li, \"Bivalent Gadolinium Ions Forming Injectable Hydrogels for Simultaneous In Situ Vaccination Therapy and Imaging of Soft Tissue Sarcoma,\" Advanced Healthcare Materials 12, no. 26 (2023): 2300877, https://doi.org/10.1002/adhm.202300877. The above article, published online on 11 August 2023 in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the authors; the journal Editor-in-Chief, Uta Goebel; and Wiley-VCH GmbH. A third party alerted the editor to concerns about an error in terminology: Divalent/bivalent Gadolinium2+ is referenced throughout the text, but the dominant and correct form is trivalent (Gadolinium3+). The authors acknowledge this error, noting that the stable oxidation state of gadolinium under physiological conditions is indeed +3, not +2. They confirm that this was an error in chemical terminology, not in the materials or experimental design, as the commercially available Gd(III)-gadodiamide was used. Additionally, the authors identified an error in the hematoxylin and eosin (H&E) staining results of Figure 9, in which a subpanel was mistakenly replaced with a duplicate image from an alternate set of H&E staining images that the authors had prepared with different scale bars for visual optimization. The authors note that this error occurred during file reorganization and was unintentional. Because of these errors that impact the study's premise and results, the article must be retracted. A revised version of this article is available here: [https://doi.org/10.1002/adhm.71182].","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71200"},"PeriodicalIF":9.6,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0