Advanced Healthcare Materials最新文献_第3页

Functionalized Bone Implant Inspired by Lattice Defense Strategy: Grid Management, Precise and Effective Multiple-Prevention of Osteomyelitis Recurrence and Promote Bone Regeneration. 受晶格防御策略启发的功能化骨植入物：网格管理、精准有效、多重预防骨髓炎复发并促进骨再生

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-17 DOI: 10.1002/adhm.202403058

Bo Zhang, Hao Zhang, Yani Sun, Lei Chen, Kaixin Sun, Yuming Zhang, Xiaofan Hu, Kang Zhao, Zixiang Wu, Yufei Tang

{"title":"Functionalized Bone Implant Inspired by Lattice Defense Strategy: Grid Management, Precise and Effective Multiple-Prevention of Osteomyelitis Recurrence and Promote Bone Regeneration.","authors":"Bo Zhang, Hao Zhang, Yani Sun, Lei Chen, Kaixin Sun, Yuming Zhang, Xiaofan Hu, Kang Zhao, Zixiang Wu, Yufei Tang","doi":"10.1002/adhm.202403058","DOIUrl":"https://doi.org/10.1002/adhm.202403058","url":null,"abstract":"Osteomyelitis with a high recurrence rate. Timely-prevention can avoid severe consequence and death. However, conventional drug response-release has the disadvantages of unnecessary release and waste, causing ineffective prevention. Inspired by \"Lattice-defense technology\", gridding lesion areas and constructing a \"Triggered-precise response-release system\" may be an effective multiple-prevention method. Here, a new strict pH-triggered response drug controlled-release mechanism was proposed innovatively to construct a \"Triggered-precise response-release system\" and achieve multiple-effective prevention. PO4 3--Ce3+ strict pH responsive release system is prepared through simultaneous hydration reaction of solution-polymerization and compounded in bone-implant. The dispersed system only targets micro-interface contact areas, achieving gridded management of the lesion site. In a normal environment, Ce3+ is captured by PO4 3- and kept electrostatic-attraction balance, ensuring the zero-concentration Ce3+ release continuously. Once osteomyelitis recurs and pH decrease, H+ at the interface will combine with PO4 3- under electrostatic drive and disrupt potential balance, achieving the release of Ce3+ only when the infection recurs. In vivo experiments was confirmed effective prevention and excellent promote bone regeneration. The adoption of \"Lattice defense technology\" has achieved accuracy spatiotemporal of drug delivery. Even if other lesion sites unfortunately recur again, effective-prevention can be guaranteed. Bone-implant show great potential in preventing osteomyelitis.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403058"},"PeriodicalIF":10.0,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tuning Helical Peptide Nanofibers as a Sublingual Vaccine Platform for a Variety of Peptide Epitopes.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-15 DOI: 10.1002/adhm.202402055

Emily F Roe, Helena Freire Haddad, Kat M Lazar, Peiying Liu, Joel H Collier

{"title":"Tuning Helical Peptide Nanofibers as a Sublingual Vaccine Platform for a Variety of Peptide Epitopes.","authors":"Emily F Roe, Helena Freire Haddad, Kat M Lazar, Peiying Liu, Joel H Collier","doi":"10.1002/adhm.202402055","DOIUrl":"https://doi.org/10.1002/adhm.202402055","url":null,"abstract":"Mucosal immune responses to vaccination are essential for achieving full protection against pathogens entering their host at mucosal sites. However, traditional parenteral immunization routes commonly fail to raise significant mucosal immunity. Sublingual immunization is a promising alternative delivery route to raise robust immune responses both systemically and at mucosal sites, and nanomaterial-based subunit vaccine platforms offer opportunities for raising epitope-specific responses. Here, sublingual immunization is reported using the Coil29 platform of coiled-coil self-assembling peptide nanofibers. The successful immunization with epitopes of varying physicochemical properties by including mucus-modulating components - namely sequences of proline, alanine, and serine (PAS) is demonstrated. PASylation is shown to decrease mucin complexation and increase epithelial penetration in vitro, enabling sublingual immunization against a variety of selected peptide epitopes in vivo. Coil29 fibers are also readily formed into tablets for solid-state dosing formulations and maintain their immunogenicity in this state. Previous sublingual peptide nanofiber immunotherapies have been based on different structures, such as highly stable β-sheets. The present work demonstrates that alternatively folded structures such as α-helical nanofibers can also be rendered sublingually immunogenic, enabling immunization with a variety of peptide epitopes and offering additional ways to specify mucus interactions, delivery state, dosing, and formulation.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2402055"},"PeriodicalIF":10.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Nattokinase-Loaded Nanozyme for Alleviating Acute Myocardial Infarction via Thrombolysis and Antioxidation.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-15 DOI: 10.1002/adhm.202402763

Yingchao Shi, Chuanfen Liu, Yuesheng Gui, Yike Guo, Yuanhao Zhang, Jiangpeng Pan, Hao Tang, Chuanyu Gao, Junyue Xing, Yu Han, Wei Jiang

{"title":"A Nattokinase-Loaded Nanozyme for Alleviating Acute Myocardial Infarction via Thrombolysis and Antioxidation.","authors":"Yingchao Shi, Chuanfen Liu, Yuesheng Gui, Yike Guo, Yuanhao Zhang, Jiangpeng Pan, Hao Tang, Chuanyu Gao, Junyue Xing, Yu Han, Wei Jiang","doi":"10.1002/adhm.202402763","DOIUrl":"https://doi.org/10.1002/adhm.202402763","url":null,"abstract":"Acute myocardial infarction (MI) induced by thrombus formation is a prevalent cardiovascular disorder, and thrombolytic therapy continues to be a principal treatment modality. Prior research indicates a substantial association among MI, thrombosis, and the activation of oxidative stress pathways. The effectiveness of current thrombolytic drugs is relatively constrained, and the need for innovative and versatile thrombolytic medications remains critical. Nattokinase (NK) is a naturally-occurring enzyme known for its thrombolytic characteristics. Nonetheless, nattokinase's limited stability and susceptibility to inactivation in biological systems have impeded its clinical utility. This study designs a manganese oxide nanozyme (MnOx) loaded with NK (MnOx@NK), which exhibits both antioxidant and thrombolytic function. The administration of MnOx@NK through tail vein injection significantly restores vascular function and further reduces myocardial injury in a mouse model of myocardial infarction, demonstrating a pronounced protective effect against oxidative stress. These findings indicate that nattokinase-loaded nanozymes can be a promising approach for treating acute myocardial infarction, providing a new strategy for clinical application.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2402763"},"PeriodicalIF":10.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiation-Resistant Bacteria Deinococcus radiodurans-Derived Extracellular Vesicles as Potential Radioprotectors.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-15 DOI: 10.1002/adhm.202403192

Jeong Moo Han, Godfrey Mwiti, Seo-Joon Yeom, Jaeyoon Lim, Woo Sik Kim, Sangyong Lim, Seung-Taik Lim, Eui-Baek Byun

{"title":"Radiation-Resistant Bacteria Deinococcus radiodurans-Derived Extracellular Vesicles as Potential Radioprotectors.","authors":"Jeong Moo Han, Godfrey Mwiti, Seo-Joon Yeom, Jaeyoon Lim, Woo Sik Kim, Sangyong Lim, Seung-Taik Lim, Eui-Baek Byun","doi":"10.1002/adhm.202403192","DOIUrl":"https://doi.org/10.1002/adhm.202403192","url":null,"abstract":"The increasing use of radiation presents a risk of radiation exposure, making the development of radioprotectors necessary. In the previous study, it is investigated that Deinococcus radiodurans (R1-EVs) exert the antioxidative properties. However, the radioprotective activity of R1-EVs remains unclear. In the present study, the protective effects of R1-EVs against total body irradiation (TBI)-induced acute radiation syndrome (ARS) are investigated. To assess R1-EVs' radioprotective efficacy, ARS is induced in mice with 8 Gy of TBI, and protection against hematopoietic (H)- and gastrointestinal (GI)-ARS is evaluated. The survival rate of irradiated mice group decreases substantially after irradiation. In contrast, pretreatment with R1-EVs increases the survival rates of the mice. The administration of R1-EVs provides effective protection against radiation-induced death of bone marrow cells and splenocytes by scavenging reactive oxygen species (ROS). Additionally, R1-EVs protect both intestinal stem and epithelial cells from radiation-induced apoptosis. R1-EVs stimulate the production of short-chain fatty acids in the gastrointestinal tract, suppress proinflammatory cytokines, and increase regulatory T cells in pretreated mice versus the irradiation-only group. Proteomic analysis shows that the R1-EV proteome is significantly enriched with proteins involved in oxidative stress response. These findings highlight R1-EVs as potent radioprotectors with applications against radiation damage and ROS-mediated diseases.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403192"},"PeriodicalIF":10.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Streamlining the Highly Reproducible Fabrication of Fibrous Biomedical Specimens toward Standardization and High Throughput.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-15 DOI: 10.1002/adhm.202402527

Zan Lamberger, Camilla Mussoni, Nicoletta Murenu, Mateo Andrade Mier, Philipp Stahlhut, Taufiq Ahmad, Natascha Schaefer, Carmen Villmann, Sarah Zwingelberg, Jürgen Groll, Gregor Lang

{"title":"Streamlining the Highly Reproducible Fabrication of Fibrous Biomedical Specimens toward Standardization and High Throughput.","authors":"Zan Lamberger, Camilla Mussoni, Nicoletta Murenu, Mateo Andrade Mier, Philipp Stahlhut, Taufiq Ahmad, Natascha Schaefer, Carmen Villmann, Sarah Zwingelberg, Jürgen Groll, Gregor Lang","doi":"10.1002/adhm.202402527","DOIUrl":"https://doi.org/10.1002/adhm.202402527","url":null,"abstract":"Soft nano- and microfiber-based polymer scaffolds bear enormous potential for their use in cell culture and tissue engineering since they mimic natural collagen structures and may thus serve as biomimetic adhesive substrates. They have, however, so far been restricted to small-scale production in research labs with high batch-to-batch variation. They are commonly produced via electrospinning or melt electrowriting and their delicate nature poses obstacles in detachment, storage, and transportation. This study focuses on overcoming challenges in the high throughput production and practical handling, introducing new methods to reproducibly prepare such scaffolds suitable for quantitative cell culture applications. Attention is given to the seamless handling and transfer of samples without compromising structural integrity. Challenges in detaching fibers without damage as well as storage, and transport are addressed. Cell culture studies demonstrate the methodological advantages, emphasizing the potential for standardized testing and biological readouts of these delicate fiber materials. The developed methods are applicable across various electrospinning and melt electrowriting approaches and can essentially contribute to their utilization in laboratory research and commercial applications.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2402527"},"PeriodicalIF":10.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

5-Fluorouracil Loaded Prebiotic-Probiotic Liposomes Modulating Gut Microbiota for Improving Colorectal Cancer Chemotherapy.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-15 DOI: 10.1002/adhm.202403587

Xujie Sun, Xiaoting Shan, Binyu Zhu, Ying Cai, Zongyan He, Lingli Zhou, Lixuan Yin, Yiran Liu, Kaiyue Liu, Tian Zhang, Ning Yang, Yaping Li, Tianqun Lang

{"title":"5-Fluorouracil Loaded Prebiotic-Probiotic Liposomes Modulating Gut Microbiota for Improving Colorectal Cancer Chemotherapy.","authors":"Xujie Sun, Xiaoting Shan, Binyu Zhu, Ying Cai, Zongyan He, Lingli Zhou, Lixuan Yin, Yiran Liu, Kaiyue Liu, Tian Zhang, Ning Yang, Yaping Li, Tianqun Lang","doi":"10.1002/adhm.202403587","DOIUrl":"https://doi.org/10.1002/adhm.202403587","url":null,"abstract":"The gut microbiota exerts inhibitory effects on the occurrence and progression of colorectal cancer (CRC) through various mechanisms. Compared to traditional microbiota regulation methods, prebiotics and probiotics demonstrate significant advantages in terms of safety and patient adaptability. Their synergy not only improves the intestinal environment but also enhances the host's anti-tumor immune response. 5-Fluorouracil (5-FU) is a first-line chemotherapy drug that has a short half-life and low bioavailability. However, if administered in an untargeted manner, 5-FU also causes adverse reactions. Liposomes can improve the pharmacokinetic profile of drugs and provide targeted delivery to the tumor site, thereby reducing side effects. In this work, a 5-FU-loaded liposome is modified with the prebiotic xylan derivative Sxy and the probiotic Akkermansia muciniphila active phospholipid homolog 1,2-dipalmitoylphosphatidy-lethanolamine (DPPE) to construct FLSK. The latter effectively prolongs the intestinal transport and release of 5-FU, maintaining high drug concentrations at the tumor site. FLSK is found to inhibit tumor growth and significantly extends the survival period of mice. In addition, FLSK promotes anti-tumor immunity and regulation of the gut microbiota. Combining the merits of prebiotics and probiotics, FLSK provides a potential strategy for integrating chemotherapy with gut microbiota regulation therapy for the treatment of CRC.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403587"},"PeriodicalIF":10.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting of Low-Immunogenic Poly(ethylene glycol) Nanoparticles for Photothermal-Enhanced Immunotherapy.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-15 DOI: 10.1002/adhm.202402954

Mengqi Li, Zhiliang Gao, Ning Wang, Kanaparedu P C Sekhar, Jingcheng Hao, Jiwei Cui

引用次数: 0

Structurally Diverse Gelatin-Based Electrospun Membranes for Ultrasound Imaging.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-12 DOI: 10.1002/adhm.202404333

Lingcong Zeng, Dandan Kang, Linglin Zhu, Deng-Guang Yu, Wenliang Song

{"title":"Structurally Diverse Gelatin-Based Electrospun Membranes for Ultrasound Imaging.","authors":"Lingcong Zeng, Dandan Kang, Linglin Zhu, Deng-Guang Yu, Wenliang Song","doi":"10.1002/adhm.202404333","DOIUrl":"https://doi.org/10.1002/adhm.202404333","url":null,"abstract":"Nanofiber membranes, produced through electrospinning, offer significant promise in the biomedical field due to their large surface area and strong mechanical properties. Their versatility is evident across applications such as drug delivery, wound healing, filtration, catalysis, and heritage conservation. However, the potential of electrospun membranes for advanced biomedical uses, like medical ultrasonic couplants, remains largely untapped. Current ultrasonic couplants have notable limitations, often failing to meet clinical needs and affecting patient comfort during diagnostics. To address this, gelatin/polyvinyl alcohol nanofiber membranes with various fibrous structures are developed and characterized, specifically designed for B-mode ultrasonography. Through multi-fluid electrospinning, three distinct nanofiber structures with average diameters of 325 ± 6.172, 349 ± 9.189, and 361 ± 2.117 nm are created. Electron microscopy confirmed these membranes' uniformity and smooth, hydrophilic surfaces. After crosslinking, the membranes exhibited enhanced mechanical strength and biodegradability. In ultrasound imaging trials, these nanofibers demonstrated superior clarity compared to commonly used polymer materials, revealing detailed body part structures. This study highlights the critical role of diverse nanofiber membranes in ultrasound imaging and positions them as promising alternatives to conventional couplants, with the potential to revolutionize ultrasound diagnostics and therapeutic practices.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2404333"},"PeriodicalIF":10.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142816691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of Adipose Extracellular Matrix and Reduced Graphene Oxide Nanocomposites for Spinal Cord Injury Repair.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-12 DOI: 10.1002/adhm.202402775

Kest Verstappen, Lara Bieler, Nathalie Barroca, Ewald M Bronkhorst, Sébastien Couillard-Després, Sander C G Leeuwenburgh, Paula A A P Marques, Alexey Klymov, X Frank Walboomers

{"title":"Application of Adipose Extracellular Matrix and Reduced Graphene Oxide Nanocomposites for Spinal Cord Injury Repair.","authors":"Kest Verstappen, Lara Bieler, Nathalie Barroca, Ewald M Bronkhorst, Sébastien Couillard-Després, Sander C G Leeuwenburgh, Paula A A P Marques, Alexey Klymov, X Frank Walboomers","doi":"10.1002/adhm.202402775","DOIUrl":"https://doi.org/10.1002/adhm.202402775","url":null,"abstract":"Graphene-based materials (GBMs) hold strong promise to restore the spinal cord microenvironment and promote functional recovery after spinal cord injury (SCI). Nanocomposites consisting of reduced graphene oxide (rGO) and adipose tissue-derived extracellular matrix (adECM) are known to promote neuronal growth in vitro and to evoke a biocompatible response in vivo when implanted on top of the intact spinal cord. In this study, pristine adECM and adECM-rGO nanocomposites are implanted directly after hemisection SCI in rats. Scaffolds composed of collagen type I (COL) are applied as negative control, based on evidence that COL triggers integrin-mediated astrogliosis. However, COL scaffolds induce orthotopic bone formation in the lesion site and are therefore excluded from further analyses. Compared to pristine adECM, adECM-rGO nanocomposites completely restore spinal cord integrity. Macrophage-mediated uptake and clearance of rGO remnants is observed as early as 3 weeks post-implantation. Nanocomposites show an elevated presence of βIII-tubulin-positive axons in the host-material interface after 8 weeks, yet scaffold penetration by axons is only occasionally observed. This is partially due to an increased expression of chondroitin sulfate proteoglycans (CSPGs) within the nanocomposites, even though reactive astrogliosis is unaltered. Despite the complete restoration of tissue architecture, adECM-rGO treatment does not significantly improve functional recovery.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2402775"},"PeriodicalIF":10.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142816671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electroconductive Nanocellulose, a Versatile Hydrogel Platform: From Preparation to Biomedical Engineering Applications.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-12 DOI: 10.1002/adhm.202403983

Myoung Joon Jeon, Aayushi Randhawa, Hojin Kim, Sayan Deb Dutta, Keya Ganguly, Tejal V Patil, Jieun Lee, Rumi Acharya, Hyeonseo Park, Youjin Seol, Ki-Taek Lim

{"title":"Electroconductive Nanocellulose, a Versatile Hydrogel Platform: From Preparation to Biomedical Engineering Applications.","authors":"Myoung Joon Jeon, Aayushi Randhawa, Hojin Kim, Sayan Deb Dutta, Keya Ganguly, Tejal V Patil, Jieun Lee, Rumi Acharya, Hyeonseo Park, Youjin Seol, Ki-Taek Lim","doi":"10.1002/adhm.202403983","DOIUrl":"https://doi.org/10.1002/adhm.202403983","url":null,"abstract":"Nanocelluloses have garnered significant attention recently in the attempt to create sustainable, improved functional materials. Nanocellulose possesses wide varieties, including rod-shaped crystalline cellulose nanocrystals and elongated cellulose nanofibers, also known as microfibrillated cellulose. In recent times, nanocellulose has sparked research into a wide range of biomedical applications, which vary from developing 3D printed hydrogel to preparing structures with tunable characteristics. Owing to its multifunctional properties, different categories of nanocellulose, such as cellulose nanocrystals, cellulose nanofibers, and bacterial nanocellulose, as well as their unique properties are discussed here. Here, different methods of nanocellulose-based hydrogel preparation are covered, which include 3D printing and crosslinking methods. Subsequently, advanced nanocellulose-hydrogels addressing conductivity, shape memory, adhesion, and structural color are highlighted. Finally, the application of nanocellulose-based hydrogel in biomedical applications is explored here. In summary, numerous perspectives on novel approaches based on nanocellulose-based research are presented here.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403983"},"PeriodicalIF":10.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142816674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0