Advanced Healthcare Materials最新文献_第4页

Melt Electrowriting of Polyhydroxyalkanoates for Enzymatically Degradable Scaffolds. 用于可酶降解支架的聚羟基烷酸酯熔融电泳。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-11-12 DOI: 10.1002/adhm.202401504

Magdalena Z Gładysz, Didi Ubels, Marcus Koch, Armin Amirsadeghi, Frederique Alleblas, Sander van Vliet, Marleen Kamperman, Jeroen Siebring, Anika Nagelkerke, Małgorzata K Włodarczyk-Biegun

{"title":"Melt Electrowriting of Polyhydroxyalkanoates for Enzymatically Degradable Scaffolds.","authors":"Magdalena Z Gładysz, Didi Ubels, Marcus Koch, Armin Amirsadeghi, Frederique Alleblas, Sander van Vliet, Marleen Kamperman, Jeroen Siebring, Anika Nagelkerke, Małgorzata K Włodarczyk-Biegun","doi":"10.1002/adhm.202401504","DOIUrl":"https://doi.org/10.1002/adhm.202401504","url":null,"abstract":"Melt electrowriting (MEW) enables precise scaffold fabrication for biomedical applications. With a limited number of processable materials with short and tunable degradation times, polyhydroxyalkanoates (PHAs) present an interesting option. Here, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and a blend of PHBV and poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (PHBV+P34HB) are successfully melt electrowritten into scaffolds with various architectures. PHBV+P34HB exhibits greater thermal stability, making it a superior printing material compared to PHBV in MEW. The PHBV+P34HB scaffolds subjected to enzymatic degradation show tunable degradation times, governed by enzyme dilution, incubation time, and scaffold surface area. PHBV+P34HB scaffolds seeded with human dermal fibroblasts (HDFs), demonstrate enhanced cell adherence, proliferation, and spreading. The HDFs, when exposed to the enzyme solutions and enzymatic degradation residues, show good viability and proliferation rates. Additionally, HDFs grown on enzymatically pre-incubated scaffolds do not show any difference in behavior compared those grown on control scaffolds. It is concluded that PHAs, as biobased materials with enzymatically tunable degradability rates, are an important addition to the already limited set of materials available for MEW technology.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2401504"},"PeriodicalIF":10.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Programmable Nanomodulators for Precision Therapy, Engineering Tumor Metabolism to Enhance Therapeutic Efficacy. 用于精准治疗的可编程纳米调节剂，通过肿瘤代谢工程提高疗效。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-11-12 DOI: 10.1002/adhm.202403019

Siwei Liu, Zhijun Liu, Huajiang Lei, Yang-Bao Miao, Jiao Chen

{"title":"Programmable Nanomodulators for Precision Therapy, Engineering Tumor Metabolism to Enhance Therapeutic Efficacy.","authors":"Siwei Liu, Zhijun Liu, Huajiang Lei, Yang-Bao Miao, Jiao Chen","doi":"10.1002/adhm.202403019","DOIUrl":"https://doi.org/10.1002/adhm.202403019","url":null,"abstract":"Tumor metabolism is crucial in the continuous advancement and complex growth of cancer. The emerging field of nanotechnology has made significant strides in enhancing the understanding of the complex metabolic intricacies inherent to tumors, offering potential avenues for their strategic manipulation to achieve therapeutic goals. This comprehensive review delves into the interplay between tumor metabolism and various facets of cancer, encompassing its origins, progression, and the formidable challenges posed by metastasis. Simultaneously, it underscores the classification of programmable nanomodulators and their transformative impact on enhancing cancer treatment, particularly when integrated with modalities such as chemotherapy, radiotherapy, and immunotherapy. This review also encapsulates the mechanisms by which nanomodulators modulate tumor metabolism, including the delivery of metabolic inhibitors, regulation of oxidative stress, pH value modulation, nanoenzyme catalysis, nutrient deprivation, and RNA interference technology, among others. Additionally, the review delves into the prospects and challenges of nanomodulators in clinical applications. Finally, the innovative concept of using nanomodulators to reprogram metabolic pathways is introduced, aiming to transform cancer cells back into normal cells. This review underscores the profound impact that tailored nanomodulators can have on tumor metabolic, charting a path toward pioneering precision therapies for cancer.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403019"},"PeriodicalIF":10.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bilayer Scaffolds Synergize Immunomodulation and Rejuvenation via Layer-Specific Release of CK2.1 and the "Exercise Hormone" Lac-Phe for Enhanced Osteochondral Regeneration. 双层支架通过层特异性释放 CK2.1 和 "运动荷尔蒙 "Lac-Phe 来协同免疫调节和再生，从而增强骨软骨再生。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-11-12 DOI: 10.1002/adhm.202402329

Po-Lin Liu, Shu-Hang He, Zhi-Han Shen, Xu-Ran Li, Qing-Song Deng, Zhan-Ying Wei, Chang-Ru Zhang, Xiao-Qiu Dou, Tong-He Zhu, Helen Dawes, Jian Lu, Shang-Chun Guo, Shi-Cong Tao

{"title":"Bilayer Scaffolds Synergize Immunomodulation and Rejuvenation via Layer-Specific Release of CK2.1 and the \"Exercise Hormone\" Lac-Phe for Enhanced Osteochondral Regeneration.","authors":"Po-Lin Liu, Shu-Hang He, Zhi-Han Shen, Xu-Ran Li, Qing-Song Deng, Zhan-Ying Wei, Chang-Ru Zhang, Xiao-Qiu Dou, Tong-He Zhu, Helen Dawes, Jian Lu, Shang-Chun Guo, Shi-Cong Tao","doi":"10.1002/adhm.202402329","DOIUrl":"https://doi.org/10.1002/adhm.202402329","url":null,"abstract":"Repairing osteochondral defects necessitates the intricate reestablishment of the microenvironment. The cartilage layer consists of a porous gelatin methacryloyl hydrogel (PGelMA) covalently crosslinked with the chondroinductive peptide CK2.1 via a \"linker\" acrylate-PEG-N-hydroxysuccinimide (AC-PEG-NHS). This layer is optimized for remodeling the senescent microenvironment in the cartilage region, thereby establishing a regenerative microenvironment that supports chondrogenesis. For the bone layer, silk fibroin methacryloyl (SilMA) is coated onto a three dimensional (3D)-printed 45S5 bioactive glass scaffold (BG scaffold). The \"exercise hormone\" N-lactoyl-phenylalanine (Lac-Phe) is loaded onto the SilMA, endowing it with diversified functions to regulate the osteogenic microenvironment. Systematic analysis in vitro reveals that PGelMA-CK2.1 shifts the microenvironment from a pro-inflammatory into an anti-inflammatory condition, and alleviates cellular senescence, thus modifying the cartilage microenvironment to improve the recruitment, proliferation and chondral differentiation of bone marrow mesenchymal stem cells (BMSCs). The scaffold bone layer enhances microvascular endothelial cell proliferation, migration, and angiogenic activities, which, couple with increased BMSC recruitment and regulatory mechanisms directing BMSC differentiation, favor a shift in the \"osteogenesis-adipogenesis\" balance toward enhanced osteogenesis. In vivo, it is found that this biphasic biomimetic scaffold favors simultaneous dual tissue regeneration. This approach facilitates the development of bioactive regenerative scaffolds and holds great potential for clinical application.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2402329"},"PeriodicalIF":10.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting TUBB3 Suppresses Anoikis Resistance and Bone Metastasis in Prostate Cancer (Adv. Healthcare Mater. 28/2024) 靶向 TUBB3 可抑制前列腺癌的 Anoikis 抗性和骨转移（Adv.）

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-11-11 DOI: 10.1002/adhm.202470181

Bingqi Dong, Yanlun Gu, Xiaojiao Sun, Xin Wang, Ying Zhou, Zhuona Rong, Jixin Zhang, Xuedong Shi, Zhuo Zhang, Xu He, Lin Chen, Qingqing Xiong, Xiaocong Pang, Yimin Cui

引用次数: 0

Polyphenol-Nanoengineered Monocyte Biohybrids for Targeted Cardiac Repair and Immunomodulation. 用于靶向心脏修复和免疫调节的多酚纳米工程单核细胞生物混合物

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-11-11 DOI: 10.1002/adhm.202403595

Jiawen Li, Guidong Gong, Yue Zhang, Yanjiang Zheng, Yunxiang He, Mei Chen, Xianglian He, Xiaolan Zheng, Xue Gong, Lei Liu, Kaiyu Zhou, Zongmin Zhao, C Wyatt Shields Iv, Yimin Hua, Yifei Li, Junling Guo

{"title":"Polyphenol-Nanoengineered Monocyte Biohybrids for Targeted Cardiac Repair and Immunomodulation.","authors":"Jiawen Li, Guidong Gong, Yue Zhang, Yanjiang Zheng, Yunxiang He, Mei Chen, Xianglian He, Xiaolan Zheng, Xue Gong, Lei Liu, Kaiyu Zhou, Zongmin Zhao, C Wyatt Shields Iv, Yimin Hua, Yifei Li, Junling Guo","doi":"10.1002/adhm.202403595","DOIUrl":"https://doi.org/10.1002/adhm.202403595","url":null,"abstract":"Myocardial infarction is one of the leading cause of cardiovascular death worldwide. Invasive interventional procedures and medications are applied to attenuate the attacks associated with ischemic heart disease by reestablishing blood flow and restoring oxygen supply. However, the overactivation of inflammatory responses and unsatisfactory drug delivery efficiency in the infarcted regions prohibit functional improvement. Here, a nanoengineered monocyte (MO)-based biohybrid system, referred to as CTAs @MOs, for the heart-targeted delivery of combinational therapeutic agents (CTAs) containing anti-inflammatory IL-10 and cardiomyogenic miR-19a to overcome the limitation of malperfusion within the infarcted myocardium through a polyphenol-mediated interfacial assembly, is reported. Systemic administration of CTAs@MOs bypasses extensive thoracotomy and intramyocardial administration risks, leading to infarcted heart-specific accumulation and sustained release of therapeutic agents, enabling immunomodulation of the proinflammatory microenvironment and promoting cardiomyocyte proliferation in sequence. Moreover, CTAs@MOs, which serve as a cellular biohybrid-based therapy, significantly improve cardiac function as evidenced by enhanced ejection fractions, increased fractional shortening, and diminished infarct sizes. This polyphenol nanoengineered biohybrid system represents a general and potent platform for the efficient treatment of cardiovascular disorders.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403595"},"PeriodicalIF":10.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammation-Responsive Functional Core-Shell Micro-Hydrogels Promote Rotator Cuff Tendon-To-Bone Healing by Recruiting MSCs and Immuno-Modulating Macrophages in Rats. 炎症反应性功能核壳微水凝胶通过招募间充质干细胞和免疫调节巨噬细胞促进大鼠肩袖肌腱到骨的愈合

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-11-11 DOI: 10.1002/adhm.202404091

Baojun Chen, Xin Zhao, Meiguang Xu, Jinlong Luo, Lang Bai, Qian Han, Yanzheng Gao, Baolin Guo, Zhanhai Yin

{"title":"Inflammation-Responsive Functional Core-Shell Micro-Hydrogels Promote Rotator Cuff Tendon-To-Bone Healing by Recruiting MSCs and Immuno-Modulating Macrophages in Rats.","authors":"Baojun Chen, Xin Zhao, Meiguang Xu, Jinlong Luo, Lang Bai, Qian Han, Yanzheng Gao, Baolin Guo, Zhanhai Yin","doi":"10.1002/adhm.202404091","DOIUrl":"https://doi.org/10.1002/adhm.202404091","url":null,"abstract":"Rotator cuff injuries often necessitate surgical intervention, but the outcomes are often unsatisfactory. The underlying reasons can be attributed to multiple factors, with the intricate inflammatory activities and insufficient presence of stem cells being particularly significant. In this study, an innovative inflammation-responsive core-shell micro-hydrogel is designed for independent release of SDF-1 and IL-4 within a single delivery system to promote tendon-to-bone healing by recruiting MSCs and modulating M2 macrophages polarization. First, a MMP-2 responsive hydrogel loaded with IL-4 (GelMA-MMP/IL-4) is synthesized by cross-linking gelatin methacrylate (GelMA) with MMP-2 substrate peptide. Then, the resulting core particles are coated with a shell of chitosan /SDF-1/hyaluronic acid (CS/HA/SDF-1) using the layer-by-layer electrostatic deposition method to form a core-shell micro-hydrogel composite. The core-shell micro-hydrogel shows sustained release of SDF-1 and MMP-2-responsive release of IL-4 associated in situ MSCs homing and smart inflammation regulation by promoting M2 macrophages polarization. Additionally, by injecting these micro-hydrogels into a rat rotator cuff tear and repair model, notable improvements of fibrocartilage layer are observed between tendon and bone. Notably, this study presents a new and potentially powerful environment-responsive drug delivery strategy that offers valuable insights for regulating the intricate micro-environment associated with tissue regeneration.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2404091"},"PeriodicalIF":10.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatiotemporal Concurrent PARP Inhibitor Sensitization Based on Radiation-Responsive Nanovesicles for Lung Cancer Chemoradiotherapy (Adv. Healthcare Mater. 28/2024) 基于辐射响应性纳米微粒的时空并发 PARP 抑制剂增敏技术用于肺癌化放疗（Adv.）

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-11-11 DOI: 10.1002/adhm.202470177

Fei Kang, Meng Niu, Zijian Zhou, Mingru Zhang, Hehe Xiong, Fantian Zeng, Jing Wang, Xiaoyuan Chen

引用次数: 0

Masthead: (Adv. Healthcare Mater. 28/2024) 刊头：（Adv. Healthcare Mater. 28/2024）

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-11-11 DOI: 10.1002/adhm.202470178

引用次数: 0

Biomimetic Nano-Regulator that Induces Cuproptosis and Lactate-Depletion Mediated ROS Storm for Metalloimmunotherapy of Clear Cell Renal Cell Carcinoma (Adv. Healthcare Mater. 28/2024) 仿生纳米调节器可诱导杯突和乳酸耗竭介导的 ROS 风暴，用于透明细胞肾细胞癌的金属免疫疗法（Adv.）

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-11-11 DOI: 10.1002/adhm.202470182

Xiaotong Xu, Huimin Li, Binghua Tong, Weijie Zhang, Xiaofei Wang, Yue Wang, Geng Tian, Zhaowei Xu, Guilong Zhang

引用次数: 0

Electrohydrodynamic Direct-Writing Micro/Nanofibrous Architectures: Principle, Materials, and Biomedical Applications (Adv. Healthcare Mater. 28/2024) 电流体动力直写微/纳米纤维结构：原理、材料和生物医学应用（Adv.）

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-11-11 DOI: 10.1002/adhm.202470179

Zhengjiang Liu, Jinqiao Jia, Qi Lei, Yan Wei, Yinchun Hu, Xiaojie Lian, Liqin Zhao, Xin Xie, Haiqing Bai, Xiaomin He, Longlong Si, Carol Livermore, Rong Kuang, Yi Zhang, Jiucun Wang, Zhaoyan Yu, Xudong Ma, Di Huang

引用次数: 0