Advanced Healthcare Materials最新文献_第4页

Development of a Modular Ribonucleoprotein Complex as a General Strategy to Deliver RNAi Therapeutics (Adv. Healthcare Mater. 25/2025) 模块化核糖核蛋白复合物的发展作为提供RNAi治疗的一般策略（Adv. Healthcare Mater. 25/2025）

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-29 DOI: 10.1002/adhm.70236

Nok Yin Tam, Xiaoqi Wang, Grace Chung Yan Chan, Wai Po Kong, Wai Yin Chau, Xiuqiong Fu, Kwok-Yin Wong, Hong Lok Lung, Zhi-Ling Yu, Wei Shen Aik

引用次数: 0

Collagen-Anchoring Polymer Dots Enable Rapid and Precise Detection of Microlesions in Inflammatory Bowel Disease through Perivascular Matrix Accumulation (Adv. Healthcare Mater. 25/2025) 胶原锚定聚合物点通过血管周围基质积累实现炎症性肠病微病变的快速精确检测（Adv. Healthcare Mater. 25/2025）

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-29 DOI: 10.1002/adhm.70237

Shuting Lu, Yuqiao Li, Zhuang Zhang, Minglei Teng, Jingwen Hou, Xi Tan, Qing Lu, Liqin Xiong

引用次数: 0

An Ultra-Flexible Neural Electrode with Bioelectromechanical Compatibility and Brain Micromotion Detection. 具有生物机电兼容和脑微运动检测的超柔性神经电极。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-28 DOI: 10.1002/adhm.202503101

Donglei Chen, Yu Lu, Shuo Zhang, Wenqi Zhang, Zejie Yu, Shuideng Wang, Zhi Qu, Mingxing Cheng, Yiqing Yao, Deheng Wang, Zhan Yang, Lixin Dong

{"title":"An Ultra-Flexible Neural Electrode with Bioelectromechanical Compatibility and Brain Micromotion Detection.","authors":"Donglei Chen, Yu Lu, Shuo Zhang, Wenqi Zhang, Zejie Yu, Shuideng Wang, Zhi Qu, Mingxing Cheng, Yiqing Yao, Deheng Wang, Zhan Yang, Lixin Dong","doi":"10.1002/adhm.202503101","DOIUrl":"https://doi.org/10.1002/adhm.202503101","url":null,"abstract":"Neural electrodes, as core components of brain-computer interfaces(BCIs), face critical challenges in achieving stable mechanical coupling with brain tissue to ensure high-quality signal acquisition. Current flexible electrodes, including semi-invasive meningeal-attached types and implantable cantilever designs, exhibit significant mechanical mismatches (elastic modulus 5-6 orders higher than brain tissue) due to material/structural limitations, leading to interfacial slippage. While thread-like implants (e.g., Neuralink's electrodes) improve compliance via elongated structures, quantitative characterization of mechano-bioelectric interactions remains unexplored. This study proposes a bioelectromechanical coupling strategy, emphasizing synchronized motion between the electrode and the brain tissue through exposed-end deformation. A 4-channel ultra-flexible electrode (40 mm in length, 164 µm in width, and 3 µm in thickness) is optimized using finite-element simulations and zero relative-motion criteria, achieving an equivalent stiffness of 0.023 N m-1-matching brain tissue micromotion stiffness. A nanorobotic manipulator installed inside a scanning electron microscope(SEM) with an atomic force microscope(AFM) cantilever enabled precision characterization under the simulated displacement of 25 µm, revealing interfacial forces of 575 nN and piezoresistive sensitivities of 6.4 pA mm-1 (length) and 10.2 pA µm-1 (displacement). The dual-functionality (signal acquisition and micromotion sensing) electrodes demonstrate breakthrough potential, establishing quantitative design standards for next-generation bioelectronic implants.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e03101"},"PeriodicalIF":9.6,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell Calcification Models and Their Implications for Medicine and Biomaterial Research. 细胞钙化模型及其在医学和生物材料研究中的意义。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-27 DOI: 10.1002/adhm.202501104

Luke Hunter, Caterina Vanelli Coralli, Robert Dzhanaev, Aaron Morgan, Willi Jahnen-Dechent, Sergio Bertazzo

{"title":"Cell Calcification Models and Their Implications for Medicine and Biomaterial Research.","authors":"Luke Hunter, Caterina Vanelli Coralli, Robert Dzhanaev, Aaron Morgan, Willi Jahnen-Dechent, Sergio Bertazzo","doi":"10.1002/adhm.202501104","DOIUrl":"https://doi.org/10.1002/adhm.202501104","url":null,"abstract":"The evolutionary significance of calcium-based minerals is highlighted by the division of life between those animals with backbones (vertebrates) and those without (invertebrates). Calcification, or biomineralization, is the process by which the tissues containing minerals are formed, occurring during normal physiological processes, such as bone remodeling, or in pathological conditions, like cardiovascular calcification. The 50th anniversary of the creation of the first true calcification cell culture model was in 2024, and these have become increasingly important to many fields of research in biology and medicine. Both the literature and experimental protocols associated with cell calcification models have become extremely fragmented across the many different research streams pursued. Here, it is aimed to give a comprehensive overview of the range of models available, and the approaches taken in these models, highlighting when and how methodological divergences arise, and identifying their most common issues. Ultimately, it is aimed to propose solutions to improve both replicability and the scientific relevance of such models. Cell models are fundamental to understanding pathologies where calcification is present and to improve knowledge of the most fundamental tissues in vertebrates: bones and teeth.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e01104"},"PeriodicalIF":9.6,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145172100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Theranostic Probiotic Engineered Living Materials That Dynamically Respond to Inflammation Markers. 对炎症标志物动态响应的治疗性益生菌工程生物材料。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-26 DOI: 10.1002/adhm.202503809

Gokce Altin-Yavuzarslan, Sierra M Brooks, James O Park, Kevin B Reed, McKenna Flynn, Olivia L Lanier, Hongyuan Lu, Hal S Alper, Alshakim Nelson

{"title":"Theranostic Probiotic Engineered Living Materials That Dynamically Respond to Inflammation Markers.","authors":"Gokce Altin-Yavuzarslan, Sierra M Brooks, James O Park, Kevin B Reed, McKenna Flynn, Olivia L Lanier, Hongyuan Lu, Hal S Alper, Alshakim Nelson","doi":"10.1002/adhm.202503809","DOIUrl":"https://doi.org/10.1002/adhm.202503809","url":null,"abstract":"The development of smart, implantable devices localized at the site of inflammation to conditionally and proactively combat active inflammation for inflammatory bowel disease (IBD), has the potential to transform the patient's quality of life compared to conventional treatment modalities. Engineered probiotic organisms can enable dynamic production of therapeutic compounds in response to inflammatory biomarkers. However, delivery and localization of these engineered organisms to the site of inflammation requires their integration into a material or device that sustains their viability and metabolic activity. To this end, a 3D printed engineered living material (ELM) is developed using an engineered probiotic organism (E. coli Nissle 1917) with genetic circuits to sense biomarkers for inflammation and respond with the production of anti-inflammatory compounds. These organisms are incorporated into poly(ethylene glycol) diacrylate (PEGDA) resins for the light-based 3D printing of 3D constructs. The organisms are physically encapsulated within the PEGDA and are fully viable and metabolically active. The 3D printed ELM devices are able to detect clinically relevant amounts of nitric oxide as an inflammatory biomarker and respond with the production of tryptamine or 1-acetyl-3-carboxyl-β-carboline as representative anti-inflammatory agents. Additionally, the ELM devices are efficacious in treating in vitro models of inflammation, including murine macrophages and intestinal epithelial cells. Looking forward, these ELM devices could serve as theranostic modalities for the long-term treatment of inflammatory disorders such as IBD.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e03809"},"PeriodicalIF":9.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145172243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Granular Hydrogels as Modular Biomaterials: From Structural Design to Biological Responses. 颗粒水凝胶作为模块化生物材料：从结构设计到生物反应。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-26 DOI: 10.1002/adhm.202502462

Asmasadat Vaziri, Renata Maia, Pei Zhang, Liliana Agresti, Jelmer Sjollema, Mohammad-Ali Shahbazi, Hélder A Santos

引用次数: 0

Biodegradable Implantable Electronics with Wireless Technology for Real-Time Clinical Applications. 生物可降解植入电子与无线技术的实时临床应用。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-26 DOI: 10.1002/adhm.202503424

Myeongki Cho, Jeong Woo Chae, Young-Jin Park, Ki Jun Yu, Sang Min Won

{"title":"Biodegradable Implantable Electronics with Wireless Technology for Real-Time Clinical Applications.","authors":"Myeongki Cho, Jeong Woo Chae, Young-Jin Park, Ki Jun Yu, Sang Min Won","doi":"10.1002/adhm.202503424","DOIUrl":"https://doi.org/10.1002/adhm.202503424","url":null,"abstract":"Wireless biodegradable electronics offer a transformative approach to transient biomedical applications by combining fully implantable, resorbable architectures with untethered communication and power delivery. These systems address key limitations of conventional implants, including infection risk, foreign body response, and the need for surgical retrieval. As biodegradable implants are designed to disappear after fulfilling their function, wireless operation is essential to avoid permanent components such as transcutaneous wires. Advances in bioresorbable materials have enabled electronic components capable of functioning over clinically relevant timescales before safely degrading in vivo. Wireless communication techniques, including radio frequency telemetry, LC resonators, and ultrasound-mediated links, enable real-time data transmission with minimal energy requirements. Complementary power delivery strategies, such as inductive and capacitive coupling, acoustic energy transfer, photovoltaic harvesting, and transient batteries, support autonomous function across diverse anatomical sites. These integrated platforms have demonstrated utility in neural recording and stimulation, pressure monitoring, cardiac rhythm regulation, gastrointestinal leak detection, immune response tracking, and spatiotemporally controlled drug delivery. This review outlines recent advances in wireless biodegradable electronics, spanning materials, system design, and clinical applications, and provides a foundation for future development of transient implants tailored to short-term therapeutic and diagnostic needs.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e03424"},"PeriodicalIF":9.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Simulations of Polymer-based Drug Nanocarriers: From Physical and Structural Properties to Controlled Release. 高分子药物纳米载体的分子模拟：从物理和结构性质到控释。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-26 DOI: 10.1002/adhm.202503503

Ping Gao, Xin Jiang, Jinyu Li, Julien Nicolas, Tâp Ha-Duong

{"title":"Molecular Simulations of Polymer-based Drug Nanocarriers: From Physical and Structural Properties to Controlled Release.","authors":"Ping Gao, Xin Jiang, Jinyu Li, Julien Nicolas, Tâp Ha-Duong","doi":"10.1002/adhm.202503503","DOIUrl":"https://doi.org/10.1002/adhm.202503503","url":null,"abstract":"Polymer-based drug delivery systems have been extensively studied to overcome the limitations of free drug administration (e.g., poor solubility and stability, rapid degradation and early metabolization, short plasma half-life, low therapeutic efficacy, and occurrence of side effects). Although the vast majority of these drug delivery systems are developed using the traditional time- and resource-intensive trial-and-error method, computational techniques have received considerable attention in order to facilitate and accelerate their understanding and development. In this review, several computational techniques is presented that are commonly used to study polymer-based drug delivery systems. Then, this is discussed several computational investigations of the self-assembly and supramolecular organization of polymer nanocarriers for drug delivery applications, including drug-loaded polymer micelles and polymer prodrug nanoparticles. How modeling approaches can rationalize the drug loading and release from polymer drug delivery systems is further examined, including studies which aim to better understand how physical, chemical, or biological stimuli can trigger the drug release. Machine learning possibilities for extending physics-based molecular simulation efficiency and predictive power have also been briefly discussed.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e03503"},"PeriodicalIF":9.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145172234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hybrid Ultrasound-Enhanced and Self-Cascade-Catalysis-Mediated System with Lewis Acid Active Centers for Treating MRSA-Infected Osteomyelitis. 混合超声增强和自级联催化介导系统与刘易斯酸活性中心治疗mrsa感染的骨髓炎。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-26 DOI: 10.1002/adhm.202502586

Panyue Liu, Shuxin Lu, Hao Cheng, Meiwen An, Jiqiang Guo, Xiaohong Yao, Paul K Chu, Xiangyu Zhang

{"title":"Hybrid Ultrasound-Enhanced and Self-Cascade-Catalysis-Mediated System with Lewis Acid Active Centers for Treating MRSA-Infected Osteomyelitis.","authors":"Panyue Liu, Shuxin Lu, Hao Cheng, Meiwen An, Jiqiang Guo, Xiaohong Yao, Paul K Chu, Xiangyu Zhang","doi":"10.1002/adhm.202502586","DOIUrl":"https://doi.org/10.1002/adhm.202502586","url":null,"abstract":"Conventional nanoenzymes for treating methicillin-resistant Staphylococcus aureus (MRSA)-infected osteomyelitis face serious limitations, including instability caused by valence cycling and impaired reactive oxygen species (ROS) generation by hypoxia. Here, we present Lewis acid nanoenzymes (Cu/ZM-Ca), which avoids valence cycling by through electron-pair-mediated hydrogen peroxide (H2O2) cleavage, exhibiting higher stability compared to compared to conventional Fenton catalysts. The ZSM-5 zeolite framework facilitates the synergizes of 3D Lewis acid centers with ultrasound to achieve on-demand generation of H2O2 through hydrolysis of calcium peroxide (CaO2) to enhance ROS generation under hypoxic conditions; and amplification of cavitation effects to achieve deep tissue penetration. The electron-pair catalytic mechanism is oxygen-independent, making Cu/ZM-Ca suitable for hypoxic deep-tissue infections. Density Functional Theory calculations reveal that the Lewis acid site reduces the activation energy of H2O2 through enhanced adsorption, allowing direct cleavage of the O─O bond without metal oxidation. This hybrid system reduces MRSA survival by 5-logs in 15 min through synergistic membrane disruption and metabolic blockade. In vivo, ultrasound-activated Cu/ZM-Ca cleared 99.5% of bacteria and resulted in an effective increase in bone regeneration (45.7% vs 24.5% BV/TV). This work establishes a novel class of hypoxia-resistant nanoenzymes based on Lewis acid catalysis, overcoming fundamental constraints of conventional ROS therapies.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e02586"},"PeriodicalIF":9.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145172240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell-Membrane-Camouflaged Biomimetic Nanomedicines for Cerebral Ischemia-Reperfusion Injury Treatment. 细胞膜伪装仿生纳米药物治疗脑缺血再灌注损伤。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-25 DOI: 10.1002/adhm.202502936

Yihong Su, Bingcang Huang, Dingsheng Liu, Luodan Yu, Yu Chen

{"title":"Cell-Membrane-Camouflaged Biomimetic Nanomedicines for Cerebral Ischemia-Reperfusion Injury Treatment.","authors":"Yihong Su, Bingcang Huang, Dingsheng Liu, Luodan Yu, Yu Chen","doi":"10.1002/adhm.202502936","DOIUrl":"https://doi.org/10.1002/adhm.202502936","url":null,"abstract":"Cerebral ischemia-reperfusion injury (CIRI) involves complex pathological processes, including multifaceted inflammatory responses and the extensive recruitment of immune cells, ultimately leading to neuronal damage and functional impairment. Although nanomedicine-based delivery platforms have demonstrated considerable potential in the treatment of CIRI, their therapeutic efficacy is frequently hindered by rapid systemic clearance and non-specific biodistribution. In recent years, Cell-Membrane-Camouflaged Biomimetic Nanomedicines (CMBNs) have emerged as a promising strategy to address these challenges, owing to their inherent biocompatibility and targeting capabilities. By mimicking the structure and function of natural cell membranes, these nanosystems enable immune evasion, extend systemic circulation, and enhance targeted delivery to sites of inflammation. This review systematically summarizes the preparation methods of CMBNs, elucidates the functional properties imparted by membranes derived from various cellular sources (including erythrocytes, platelets, and immune cells), and discusses the targeting enhancements achieved via surface modifications. Furthermore, this review addresses the challenges faced in the clinical translation of these bio-nanosystems, including large-scale production, quality control, potential toxicity and biosafety concerns. By thoroughly examining the application of cell membrane-based bionanosystems in CIRI therapy, this review aims to offer both theoretical and practical guidance for the future development of efficient and safe bionanotherapeutics.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e02936"},"PeriodicalIF":9.6,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0