Advanced Healthcare Materials最新文献_第4页

Enzyme-Activatable Probe for Tumor Bimodal Imaging, Intraoperative Navigation, and Urinalysis. 酶激活探针用于肿瘤双峰成像、术中导航和尿液分析。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-10-16 DOI: 10.1002/adhm.71862

Meilin Xu, Yao Dong, Yu Wang, Xiaole Zhou, Leyu Wang

{"title":"Enzyme-Activatable Probe for Tumor Bimodal Imaging, Intraoperative Navigation, and Urinalysis.","authors":"Meilin Xu, Yao Dong, Yu Wang, Xiaole Zhou, Leyu Wang","doi":"10.1002/adhm.71862","DOIUrl":"https://doi.org/10.1002/adhm.71862","url":null,"abstract":"We develope an enzyme-activatable platform (NO2-RGD-Gd) for the integrated urinary biomarker detection, highcontrast fluorescence-magnetic resonance (MR) dualmodal imaging, and real-time image-guided surgical navigation within a single molecule. The advantages, including the favorable tumor-targeting affinity (RGD peptide), high renal clearance efficiency, and tumor-specific fluorescence activation, are achieved by rationally engineering the molecular architecture. Benefiting from these characteristics, the NO2-RGD-Gd effectively bridges the boundary between diagnosis and therapy, achieving outstanding combinatorial performance in in vivo applications. It allows early and precise diagnosis through urinary biomarkers, provides anatomical-pathological and molecular imaging information of tumor lesions via fluorescence-MR dual-modal imaging, and delineates tumor boundaries for accurate surgical navigation relying on tumor-targeted activatable fluorescence imaging signals. Furthermore, all these processes can be realized simply via intravenous injection, offering a more efficient and feasible strategy for integrated diagnostic and therapeutic applications.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71862"},"PeriodicalIF":11.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Self-Adjuvant Photothermal Carbon Dot-Based Nanovaccine for Multimodal Nasopharyngeal Cancer Treatment and Prophylaxis 用于鼻咽癌多模式治疗和预防的自辅助光热碳点纳米疫苗

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-10-16 Epub Date: 2026-09-07 DOI: 10.1002/adhm.71703

Ruiqi Ji, Yijun Mei, Zhiqiang Wang, Mingwu Shen, Xiangyang Shi

{"title":"A Self-Adjuvant Photothermal Carbon Dot-Based Nanovaccine for Multimodal Nasopharyngeal Cancer Treatment and Prophylaxis","authors":"Ruiqi Ji, Yijun Mei, Zhiqiang Wang, Mingwu Shen, Xiangyang Shi","doi":"10.1002/adhm.71703","DOIUrl":"10.1002/adhm.71703","url":null,"abstract":"<div>\u0000 \u0000 Developing a “full-cycle” strategy that integrates both treatment and prophylaxis remains a central challenge against nasopharyngeal carcinoma (NPC). Here, a biomimetic nanovaccine (CDC/Toy@CCM) is designed by coating toyocamycin (Toy)-loaded redox-responsive carbon dot clusters (CDCs) with homologous cancer cell membranes (CCMs). The obtained nanovaccine exhibits an average size of 70.7 nm, a high drug loading capacity (12.3%), and a superior photothermal conversion efficiency of 48.7%. The nanovaccine leverages the homologous targeting capacity of CCMs for precise tumor homing, while the disulfide-cross-linked CDCs enable glutathione-triggered drug release specifically within the tumor microenvironment for controlled chemotherapy. Under near-infrared laser irradiation, the CDCs generate robust photothermal ablation of primary tumors, and the combination of chemotherapy and photothermal therapy (PTT) effectively induces immunogenic cell death (ICD), which synergizes the self-adjuvant of CDCs and CCM antigens to generate significant antitumor response to suppress both primary and distant tumors in a bilateral NPC mouse model. In a prophylactic setting, the nanovaccine pre-vaccination generates effective immune protection against subsequent tumor challenge. This work provides a promising “full-cycle” nanoplatform that synergistically integrates PTT, chemotherapy, and immunotherapy for both NPC treatment and prophylaxis.\u0000 </div>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 38","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Pseudomembrane-Inspired Janus Hydrogel Patch With Robust Wet Adhesion and Swelling-Resistant Capabilities for Accelerated Oral Ulcer Healing. 一种假膜激发的Janus水凝胶贴片，具有强大的湿粘附和抗肿胀能力，可加速口腔溃疡愈合。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-10-15 DOI: 10.1002/adhm.71855

Zihang Fei, Zijie Zhang, Mingrui Wang, Ziyi Dai, Kai Tao, Jin Wu, Fulan Wei, Kai Qian

{"title":"A Pseudomembrane-Inspired Janus Hydrogel Patch With Robust Wet Adhesion and Swelling-Resistant Capabilities for Accelerated Oral Ulcer Healing.","authors":"Zihang Fei, Zijie Zhang, Mingrui Wang, Ziyi Dai, Kai Tao, Jin Wu, Fulan Wei, Kai Qian","doi":"10.1002/adhm.71855","DOIUrl":"https://doi.org/10.1002/adhm.71855","url":null,"abstract":"Oral ulcer healing is hindered by the slow formation, weak adhesion, and limited protection of the native pseudomembrane. Here, a light-curable, swelling-resistant Janus hydrogel patch is developed as a pseudomembrane-inspired protective barrier. The tissue-facing adhesive layer incorporates 2-phenoxyethyl acrylate (PEA), α-lipoic acid (LA), and acryloyl NHS esters, achieving a wet tissue shear adhesion strength of 142 kPa. PEA is proposed to facilitate wet tissue contact, LA participates in the polymer network, and NHS esters provide covalent anchoring. The hydrophobic network constrains water uptake, limiting further wet-state mass gain to approximately 3% and volumetric expansion to approximately 10% after 7 days. Dynamic fluid circulation tests further demonstrate the patch's durability under simulated oral conditions. The outward-facing zwitterionic layer mimics the mucosal barrier, providing protection against mechanical abrasion and chemical irritation. In a rat model, the patch maintains structural integrity for 3 days, accelerates re-epithelialization, and modulates the inflammatory microenvironment. This Janus design provides sustained protection for injured mucosal surfaces and facilitates oral ulcer healing.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71855"},"PeriodicalIF":11.0,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Easy Tailorable Alginate Film Gaining Super-Efficient Photothermal Conversion From Closed-System Design for Antibacterial and Wound Healing Applications. 易于定制的海藻酸盐薄膜获得超高效光热转换从封闭系统设计的抗菌和伤口愈合应用。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-10-15 DOI: 10.1002/adhm.71860

Zhongtao Wu, Lijia Jiang, Zhongjia Liu, Caifeng Ding, Lei Zhang, Yun Liu

{"title":"Easy Tailorable Alginate Film Gaining Super-Efficient Photothermal Conversion From Closed-System Design for Antibacterial and Wound Healing Applications.","authors":"Zhongtao Wu, Lijia Jiang, Zhongjia Liu, Caifeng Ding, Lei Zhang, Yun Liu","doi":"10.1002/adhm.71860","DOIUrl":"https://doi.org/10.1002/adhm.71860","url":null,"abstract":"Photothermal therapy plays an important role in biomedical applications. Photoswitches-based solar thermal materials could achieve super-high photothermal conversion efficiency, while it remains a great challenge to apply such materials in biomedical treatments. Herein, a photothermal conversion film with good mechanical strength is designed through electrostatically complexing Ca2+-cross-linked alginate with azobenzene-containing ammonium surfactant. The non-covalent framework provides sufficient free volume for the trans-cis isomerization of azobenzene in film state, and thereby this film gains merits of easy energy charging, energy density up to 481.0 J/g, and controlled heat release by forming a closed system with efficient photothermal conversion. The film could on-demand rise the environmental temperature at a range from room temperature to 75°C by regulating the film layers. This film exhibits characteristics of light weight, tailorability and good biocompatibility that are suitable for wound healing treatment. In animal studies, attractive wound healing promoting effect is achieved from the photothermal therapy with this film as dressing biomaterial, which is attributed to the created \"hot spring\" condition for reducing inflammation and enhancing tissue remodeling. This study realizes the biomedical application of molecular solar thermal materials by combining the photoswitches-based closed-system and biomacromolecules-based film together in a non-covalent designing strategy.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71860"},"PeriodicalIF":11.0,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Cascade-Responsive Carbon Dot-Nanogel Platform for Sequential Photothermal-Chemo Cancer Therapy via GSH and NIR Dual Activation. 通过谷胱甘肽和近红外双激活进行顺序光热化疗的级联响应碳点纳米凝胶平台。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-10-15 DOI: 10.1002/adhm.71866

Lei Yue, Jianwei Li, Yunxiao Zhang, Haolan Li, Changyu Zhang, Wen Sun, Jianjun Du, Jiangli Fan, Xiaojun Peng

{"title":"A Cascade-Responsive Carbon Dot-Nanogel Platform for Sequential Photothermal-Chemo Cancer Therapy via GSH and NIR Dual Activation.","authors":"Lei Yue, Jianwei Li, Yunxiao Zhang, Haolan Li, Changyu Zhang, Wen Sun, Jianjun Du, Jiangli Fan, Xiaojun Peng","doi":"10.1002/adhm.71866","DOIUrl":"https://doi.org/10.1002/adhm.71866","url":null,"abstract":"Chemotherapeutic agents are often limited by poor tumor-specific accumulation, leading to off-target toxicity, while monochemotherapy frequently results in multidrug resistance and suboptimal treatment outcomes. To address these challenges, we have developed a carbon dot-based nanogel drug delivery system that integrates both glutathione (GSH) and photothermal dual-responsiveness, enabling controlled drug release, active tumor targeting, and synergistic photothermal-chemotherapy. Specifically, phenylboronic acid functionalized on the nanogel surface confers tumor-targeting capability. Upon internalization into tumor cells with elevated GSH levels, the nanogel disintegrates, releasing carbon dots conjugated with the chemotherapeutic drug doxorubicin (DOX). Under near-infrared (NIR) irradiation, the carbon dots generate heat, which not only directly damages cancer cells but also triggers on-demand DOX release, achieving a synergistic photothermal-chemotherapeutic effect. Notably, both in vitro and in vivo studies reveal that this system effectively induces cancer cell necrosis through a multimodal mechanism: disruption of lysosomes, induction of DNA damage, and simultaneous suppression of heat shock protein (HSP) expression. This integrated strategy results in significantly enhanced therapeutic outcomes, overcoming key limitations of conventional chemotherapy.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71866"},"PeriodicalIF":11.0,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Self-Adaptive CoNi-Based Metal-Organic Framework for Autonomous Antibacterial Efficacy and Anti-Inflammatory Resolution in Accelerated Wound Healing. 基于coni的自适应金属有机框架在加速伤口愈合中的自主抗菌功效和抗炎解决。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-10-15 DOI: 10.1002/adhm.71851

Yu Chen, Jinyao Zheng, Qianyu Guo, Yuanhao Zhang, Mingfei Zhai, Ying Lin, Miaomiao Zhang, Jilin Tang

{"title":"A Self-Adaptive CoNi-Based Metal-Organic Framework for Autonomous Antibacterial Efficacy and Anti-Inflammatory Resolution in Accelerated Wound Healing.","authors":"Yu Chen, Jinyao Zheng, Qianyu Guo, Yuanhao Zhang, Mingfei Zhai, Ying Lin, Miaomiao Zhang, Jilin Tang","doi":"10.1002/adhm.71851","DOIUrl":"https://doi.org/10.1002/adhm.71851","url":null,"abstract":"Delayed healing of bacterially infected wounds stems from drug-resistant bacterial invasion and excessive reactive oxygen species (ROS)-driven inflammation, which necessitating strategies that simultaneously eradicate pathogens and resolve inflammation. We designed a bimetallic CoNi-based metal-organic framework (CoNi-MOF) with enhanced multienzyme-like activities: oxidase-like (OXD-like), peroxidase-like (POD-like), and catalase-like (CAT-like) activities. The superior performance arises from the synergy between Co and Ni, which shifts the d-band center of Co closer to the Fermi level than those in Co-MOF and Ni-MOF. This electronic structure enhancement facilitates substrate adsorption and lowers reaction energy barriers, accounting for the strong enzyme-like activities of CoNi-MOF. At acidic infection sites, OXD-like and POD-like activities are activated to generate antibacterial ROS, effectively eliminating drug-resistant bacteria. As bacterial clearance occurs and the wound returns to neutrality, CoNi-MOF exhibits CAT-like activity and radical scavenging capabilities to eliminate excess ROS, thereby restoring oxidative balance and mitigating inflammation. Moreover, CoNi-MOF promotes macrophage polarization from the pro-inflammatory M1 phenotype toward the pro-regenerative M2 phenotype. This pH-responsive enzymatic activity offers a self-adaptive therapeutic strategy, as validated by in vivo studies showing accelerated wound healing. This self-adaptive nanozyme platform integrates antibacterial, antioxidant, and immunomodulatory functions, offering a promising antibiotic-free treatment for drug-resistant bacterial wound infections.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71851"},"PeriodicalIF":11.0,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amino Acid-Based Piezoelectric Biocrystals for Bioelectronics: Material Design, Scalable Processing, and Biomedical Applications. 用于生物电子学的氨基酸基压电生物晶体：材料设计，可扩展处理和生物医学应用。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-10-14 DOI: 10.1002/adhm.71848

Zhihui Li, Yun Ke, Vishnu Prasad, Zhenyu Han, Irina Thomas, Pierre-Andre Cazade, Fan Yang, Jun Li

{"title":"Amino Acid-Based Piezoelectric Biocrystals for Bioelectronics: Material Design, Scalable Processing, and Biomedical Applications.","authors":"Zhihui Li, Yun Ke, Vishnu Prasad, Zhenyu Han, Irina Thomas, Pierre-Andre Cazade, Fan Yang, Jun Li","doi":"10.1002/adhm.71848","DOIUrl":"https://doi.org/10.1002/adhm.71848","url":null,"abstract":"Amino acid (AA)-based biomolecular materials, including AAs, peptides, proteins, and their co-assembled systems, are emerging as an extraordinary material platform at the interface of materials science, biology, and electronics. As the molecular building blocks of life, these systems combine inherent biocompatibility and biodegradability with a remarkable ability to assemble into low-symmetry crystalline structures that can exhibit piezoelectricity and related electromechanical functionalities. Despite their low thermal stability and weak intermolecular interactions, emerging mild and sustainable processing approaches for AA-based biocrystals are opening transformative pathways toward bioelectronic devices that structurally, topologically, and mechanically mimic biological systems while enabling energy harvesting, sensing, electrostimulation, and other functional capabilities. In this review, we aim to provide an overview of arrays of AA-based biocrystals, their scalable processing approaches, and enabled mechanoresponsive devices for biomedical applications. We begin by comprehensively introducing AA-based materials and discussing their physicochemical properties. We then review the major approaches for large-scale processing of AA-based biocrystals, focusing on preserving crystal structures, controlling dipole alignment, as well as tailoring electromechanical properties. Representative biomedical devices and applications are discussed followingly. Finally, we identify the major challenges that remained in translating AA-based materials toward practical applications and highlight the potential solutions.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71848"},"PeriodicalIF":11.0,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electronic Interactions in Co/Cu Biotomic Nanozymes for Catalytic Eradication of Gram-Positive Bacterial Biofilms. Co/Cu生物组纳米酶催化清除革兰氏阳性细菌生物膜的电子相互作用。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-10-14 DOI: 10.1002/adhm.71857

Zixuan Tang, Shan Lu, Hongjing Sui, Jincheng Shi, Haiming Sun, Mengnan Li, Can Feng, Han Lin, Qin Zhou, Feiyun Cui

{"title":"Electronic Interactions in Co/Cu Biotomic Nanozymes for Catalytic Eradication of Gram-Positive Bacterial Biofilms.","authors":"Zixuan Tang, Shan Lu, Hongjing Sui, Jincheng Shi, Haiming Sun, Mengnan Li, Can Feng, Han Lin, Qin Zhou, Feiyun Cui","doi":"10.1002/adhm.71857","DOIUrl":"https://doi.org/10.1002/adhm.71857","url":null,"abstract":"Biofilm-associated infections caused by Gram-positive pathogens remain highly resistant to conventional antibiotic therapy due to restricted drug penetration and persistent inflammatory microenvironments. Inspired by the catalytic versatility and biocompatibility of cobalt, a series of cobalt-based diatomic nanozymes were rationally engineered for catalytic antibacterial therapy. Among them, cobalt/copper diatomic nanozymes (Co/Cu-DAzymes) exhibited the most pronounced antibacterial and antibiofilm activities. Structural characterization supports the presence of highly dispersed Co and Cu coordination sites, while DFT calculations based on an idealized adjacent Co-Cu model suggest that heteronuclear electronic interactions may facilitate H2O2 activation and ROS generation.Co/Cu-DAzymes achieve more than 95% antibacterial efficiency against both Group A Streptococcus (GAS) and Staphylococcus aureus, while inhibiting biofilm formation by over 80%, with negligible cytotoxicity in vitro and in vivo. In a murine GAS-infected wound model, treatment with Co/Cu-DAzymes combined with low-dose H2O2 significantly accelerated wound closure and was associated with histological features of more advanced tissue repair. These findings highlight the potential contribution of heteronuclear electronic interactions to catalytic H2O2 activation and provide a plausible design basis for developing antibacterial dual-metal nanozymes.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71857"},"PeriodicalIF":11.0,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infection-Phase Biomolecular Coronas in Inhaled Nanomedicine. 吸入纳米医学感染期生物分子冠状病毒。

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-10-14 DOI: 10.1002/adhm.71853

Zhenchao Wu, Taikang Yao, Ning Shen

{"title":"Infection-Phase Biomolecular Coronas in Inhaled Nanomedicine.","authors":"Zhenchao Wu, Taikang Yao, Ning Shen","doi":"10.1002/adhm.71853","DOIUrl":"https://doi.org/10.1002/adhm.71853","url":null,"abstract":"An inhaled nanomedicine encounters two successive forms of remodeling: device-related changes during aerosol generation and biological conditioning after deposition. Respiratory infection adds a moving interface, as epithelial secretion, surfactant composition, plasma leakage, and neutrophil-derived material vary across airway compartments and over time. Pulmonary and disease-corona studies already establish that host environments influence nanoparticle identity. The next question is how this knowledge should change formulation selection and dosing for infected lungs. We propose an infection-phase framework based on measured, overlapping airway environments. It connects the post-aerosol particle to its surface-associated biomolecules, distinguishes this interface from aggregation and bulk mucus effects, and links analytical measurements to functional delivery. A staged research program begins with one compartment and two contrasting environments, then adds controlled particle-transfer experiments, candidate-component perturbation, and donor-level validation. Lipid nanoparticles, polymeric carriers, and nanozymes require different functional endpoints within this shared framework. The immediate translational output is a biorelevant performance stress test that identifies robust or environment-selective formulations and guides the next experiment.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71853"},"PeriodicalIF":11.0,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Viscoelasticity in Heterogeneous Glioblastoma Stem Cell Invasion in Biomimetic 3-Dimensional Hydrogels. 粘弹性在异种胶质母细胞瘤干细胞侵袭仿生三维水凝胶中的作用

IF 11 2区医学

Advanced Healthcare Materials Pub Date : 2026-10-14 DOI: 10.1002/adhm.71856

Nicole J Blaine, Arianna Skirzynska, Allysia A Chin, Julie Audet, Molly S Shoichet

{"title":"The Role of Viscoelasticity in Heterogeneous Glioblastoma Stem Cell Invasion in Biomimetic 3-Dimensional Hydrogels.","authors":"Nicole J Blaine, Arianna Skirzynska, Allysia A Chin, Julie Audet, Molly S Shoichet","doi":"10.1002/adhm.71856","DOIUrl":"https://doi.org/10.1002/adhm.71856","url":null,"abstract":"The role of viscoelasticity in cell invasion within the brain extracellular matrix (ECM) is not well understood in the context of glioblastoma (GBM). We designed biomimetic viscoelastic hyaluronan (HA)-based hydrogels to understand the effect of viscoelasticity on the invasion of heterogeneous glioblastoma stem cells (GSCs) categorized into subgroups based on molecular profile, as Reactive, Invasive, or Constructive. Hydrogel viscoelasticity was introduced to a hyaluronan-oxime (HAox) hydrogel to varying degrees through the incorporation of one of methyl cellulose, ECM-based proteins, tenascin C or collagen IV, or hydrazone chemistry. Each HAox-derived viscoelastic hydrogel exhibited significantly higher stress relaxation than HAox. We demonstrated that heterogeneous patient-derived GSC lines respond differently to viscoelasticity, with a strong correlation between greater invasion of Reactive GSCs in faster stress-relaxing matrices. This work highlights the importance of investigating the behavior of GSCs based on their heterogeneous molecular profiles and contributes to the understanding of the role of viscoelasticity in GSC invasion.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71856"},"PeriodicalIF":11.0,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0