Advanced Healthcare Materials最新文献_第4页

Intelligent Bio-MOF Nanozymes With Dual Antibacterial and Antioxidant Capabilities Through pH-Modulated Double Cascade Reactions for Anti-Fibrosis. 智能生物mof纳米酶具有双重抗菌和抗氧化能力，通过ph调节的双级联反应抗纤维化。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2026-05-06 DOI: 10.1002/adhm.71208

Jinquan Huang, Jiayan Luo, Jiwei Huang, Wenzhai Cao, Junying Chen

{"title":"Intelligent Bio-MOF Nanozymes With Dual Antibacterial and Antioxidant Capabilities Through pH-Modulated Double Cascade Reactions for Anti-Fibrosis.","authors":"Jinquan Huang, Jiayan Luo, Jiwei Huang, Wenzhai Cao, Junying Chen","doi":"10.1002/adhm.71208","DOIUrl":"https://doi.org/10.1002/adhm.71208","url":null,"abstract":"Bacterial infection and excessive reactive oxygen species (ROS) in wounds hinder healing and induce fibrosis/scarring. Metal-organic framework (MOF)-based nanozymes integrate MOF's high surface area with nanozyme catalytic properties but face toxicity issues from degradation byproducts. Herein, this study engineered a bio-MOF nanozyme using vitamin B3 as the ligand, featuring stability (the degradation rate was less than 50% in PBS for 28 days), biocompatibility (the bio-MOF nanozyme concentration threshold for cell compatibility was as high as 150 µg/mL), and pH-responsive dual enzymatic activities. In the acidic bacterial microenvironment (pH = 6.5), it activates superoxide dismutase (SOD) and peroxidase (POD) mimetic activities, generating ·OH for bactericidal effects. The antibacterial efficacy against E.coli and S.aureus was both higher than 99%. Under neutral conditions (pH = 7.4), it switches to SOD and catalase (CAT) mimetic modes, scavenging ROS and releasing O2 to create a reparative microenvironment. In vivo rat infected wound models confirmed enhanced antibacterial efficacy, inhibited excessive fibroblast proliferation, reduced aberrant collagen deposition and scar area, promoting scarless healing. The proposed dual-pathway coordinated regulation of antibacterial-antioxidant mechanisms provides a novel material strategy for addressing cutaneous fibrosis.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71208"},"PeriodicalIF":9.6,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "Core-Shell Microspheres Enabling Sustained Hydrogen Release and Peroxidase-Like Catalytic Activity for Periodontitis Therapy". 更正“核-壳微球能够持续释放氢并具有过氧化物酶样催化活性用于牙周炎治疗”。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2026-05-02 DOI: 10.1002/adhm.71211

引用次数: 0

Copolymers of Poly(Butylene Trans-1,4-Cyclohexanedicarboxylate)/Pripol as New Biomaterial Platform for Small Diameter Vascular Graft. 聚丁烯反式-1,4-环己二羧酸酯/Pripol共聚物作为小直径血管移植的新型生物材料平台。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2026-05-02 DOI: 10.1002/adhm.202504938

Edoardo Bondi, Gabriele Obino, Giulia Guidotti, Alberto Sensini, Martijn van Griensven, Antonio Junior Lepedda, Nadia Lotti, Lorenzo Moroni

{"title":"Copolymers of Poly(Butylene Trans-1,4-Cyclohexanedicarboxylate)/Pripol as New Biomaterial Platform for Small Diameter Vascular Graft.","authors":"Edoardo Bondi, Gabriele Obino, Giulia Guidotti, Alberto Sensini, Martijn van Griensven, Antonio Junior Lepedda, Nadia Lotti, Lorenzo Moroni","doi":"10.1002/adhm.202504938","DOIUrl":"https://doi.org/10.1002/adhm.202504938","url":null,"abstract":"Autologous grafts remain the clinical gold standard for vascular reconstruction; however, their use is limited by donor site morbidity, poor availability, and long-term failure. Synthetic alternatives, while effective in large-caliber vessels, fail in small-diameter applications (<6 mm) due to thrombosis, intimal hyperplasia, and biomechanical mismatch. In this context, tissue-engineered vascular grafts (TEVGs) emerge as a solution, requiring biomaterials that closely replicate the structural, mechanical, and hemocompatible properties of native vessels. Aliphatic polyesters such as polylactic acid, polyglycolic acid, and poly(ε-caprolactone) are extensively studied but show poor endothelialization and mechanical deficiency. In contrast, poly(butylene trans-1,4-cyclohexanedicarboxylate) (PBCE) attracts interest for its biocompatibility, thermal stability, and processability. Its copolymerization with Pripol 1009, a commercial fatty diacid, enables modulation of mechanical properties and degradation rate, two of the key parameters for vascular engineering. In this work, electrospun scaffolds based on these copolymers are fabricated in flat and tubular formats and characterized in terms of morphology, mechanical behavior, hemocompatibility, and endothelialization potential. Certain formulations display mechanical properties comparable to native vessels, support endothelialization and smooth muscle cell adhesion, and do not trigger coagulation pathways in in vitro assays. These results identify PBCE/Pripol copolymers as promising candidates for next-generation TEVGs, bridging the gap between synthetic reliability and biological performance in small-diameter vascular applications.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e04938"},"PeriodicalIF":9.6,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147808540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Decellularized Fibrocartilage Graft Promotes Tympanic Membrane Repair. 一种新型脱细胞纤维软骨移植促进鼓膜修复。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2026-05-02 DOI: 10.1002/adhm.202501774

Paul M Gehret, Ryan M Friedman, Gautham Nair, Stephanie L Fung, Dana D Ragbirsingh, John Germiller, Riccardo Gottardi

{"title":"A Novel Decellularized Fibrocartilage Graft Promotes Tympanic Membrane Repair.","authors":"Paul M Gehret, Ryan M Friedman, Gautham Nair, Stephanie L Fung, Dana D Ragbirsingh, John Germiller, Riccardo Gottardi","doi":"10.1002/adhm.202501774","DOIUrl":"https://doi.org/10.1002/adhm.202501774","url":null,"abstract":"Tympanoplasty repairs tympanic membrane (TM) perforations using grafts. In pediatric patients, cartilage grafts are preferred over fascia due to superior mechanical properties that prevent complications from negative middle ear pressure, including graft failure, retraction, and cholesteatoma formation. However, autologous grafts cause donor-site morbidity and increased surgical time. To overcome these limitations, we engineered an allogeneic porcine meniscus decellularized (MEND) fibrocartilage graft with a unique microchannel structure created by selective elastin and vascular digestion to promote host cell invasion and integration. We evaluated MEND in a rat TM acute perforation model, comparing outcomes to autologous cartilage and fascia grafts, the current clinical standards of care. TMs were monitored via otoendoscopy through 4 weeks, then analyzed by histology and immunohistochemistry. MEND and auricular cartilage grafts successfully closed perforations by day 3, outperforming fascia grafts which frequently dislodged due to poor mechanical integrity. However, unlike cartilage grafts, MEND fully remodeled by day 28, providing superior graft closure and tissue integration compared to both traditional materials. These findings demonstrate MEND's potential as an off-the-shelf solution for pediatric tympanoplasty.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e01774"},"PeriodicalIF":9.6,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147808555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Curcumin-Embedded Magnesium-Polyphenol Network Hydrogel for Dual Delivery of aPD1 and Promotion of Pleural Sealing in Lung Cancer Immunotherapy. 姜黄素包埋镁-多酚网络水凝胶在肺癌免疫治疗中双重递送aPD1和促进胸膜密封。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2026-05-02 DOI: 10.1002/adhm.71157

Xuhui Yang, Chuang Hu, Jinlong Wu, Haoran Luan, Guangyu Ji, Xi Liang, Xiansong Wang, Mingsong Wang

{"title":"Curcumin-Embedded Magnesium-Polyphenol Network Hydrogel for Dual Delivery of aPD1 and Promotion of Pleural Sealing in Lung Cancer Immunotherapy.","authors":"Xuhui Yang, Chuang Hu, Jinlong Wu, Haoran Luan, Guangyu Ji, Xi Liang, Xiansong Wang, Mingsong Wang","doi":"10.1002/adhm.71157","DOIUrl":"https://doi.org/10.1002/adhm.71157","url":null,"abstract":"Lung cancer remains the leading cause of cancer-related mortality worldwide, with surgically inoperable cases posing a significant clinical challenge. Although microwave ablation (MWA) is a viable treatment option for non-surgical patients, its effectiveness is often compromised by substantial complications and inadequate prevention of tumor recurrence or progression. To address these limitations, we developed a multifunctional hydrogel system (aPD1@Cur-Mg/GH) that integrates antitumor immunomodulation with pleural sealing capabilities. This hydrogel combines a gelatin methacryloyl (GelMA)/o-nitrobenzyl alcohol-modified hyaluronate (HANB) matrix (GH) with an aPD1-loaded curcumin-embedded magnesium-polyphenol network (Cur-Mg/aPD1). By utilizing the photocrosslinking properties of GelMA and HANB, the aPD1@Cur-Mg/GH hydrogel forms a robust, adhesive, and compression-resistant structure that is ideal for pleural sealing and tissue repair. Upon degradation, the hydrogel releases Mg2 + ions and curcumin, which promote M1 macrophage polarization and enhance CD8+ T cell infiltration, thereby synergizing with MWA to improve the efficacy of immune checkpoint blockade therapy. Our findings demonstrate that this dual-functional hydrogel significantly modulates the post-ablation tumor immune microenvironment and presents a promising strategy for enhancing lung cancer immunotherapy following MWA.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71157"},"PeriodicalIF":9.6,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147808543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Data Driven Review of In Vitro Electrical and Mechanical Stimulation for Post-Acute Phase Wound Healing. 体外电刺激和机械刺激对急性期后伤口愈合的数据驱动综述。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2026-05-02 DOI: 10.1002/adhm.71138

Matthew K Burgess, Ellen F Marsh, Veronica M Lucian, Malavika Nair

引用次数: 0

Microfluidic Assembly of NIR-II AIE Nanoparticles for Enhanced Photothermal Ablation of Breast Tumors. 用于增强乳腺肿瘤光热消融的NIR-II AIE纳米颗粒的微流控组装。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2026-05-02 DOI: 10.1002/adhm.71201

Xiaohua Ji, Zijuan Meng, Fulong Ma, Zhen Zhang, Ruihua Dong, Gang Liu, Zheng Zhao, Ben Zhong Tang

{"title":"Microfluidic Assembly of NIR-II AIE Nanoparticles for Enhanced Photothermal Ablation of Breast Tumors.","authors":"Xiaohua Ji, Zijuan Meng, Fulong Ma, Zhen Zhang, Ruihua Dong, Gang Liu, Zheng Zhao, Ben Zhong Tang","doi":"10.1002/adhm.71201","DOIUrl":"https://doi.org/10.1002/adhm.71201","url":null,"abstract":"Aggregation-induced emission (AIE) luminogens with strong near-infrared absorption and excellent photostability are emerging as powerful photothermal agents; however, achieving nanoscale formulations with controlled size, high stability, and near-infrared-II (NIR-II) emission remains challenging. Here, we report an NIR-II emissive AIE small molecule that can be rapidly assembled into monodisperse nanoparticles (NDA-MEPA NPs, ∼40 nm) using a microfluidic strategy that ensures reproducible control over particle size and uniformity. Surface encapsulation with DSPE-PEG2K confers excellent colloidal stability, biocompatibility, and enhanced tumor accumulation. The resulting NDA-MEPA NPs exhibit efficient photothermal conversion under 808 nm irradiation, along with dose- and time-dependent cellular uptake, and induce robust photothermal cytotoxicity in vitro. In vivo evaluations demonstrated that NDA-MEPA NPs enable high-contrast NIR-II fluorescence imaging and effective photothermal tumor ablation with minimal systemic toxicity. This work establishes a programmable microfluidic approach for constructing NIR-II AIE nanomaterials and highlights a biocompatible photothermal platform with strong potential for translational cancer therapy.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71201"},"PeriodicalIF":9.6,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147808614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorescent Nanosensor for Indole-3-Propionic Acid Detection in Gut Health Monitoring. 肠道健康监测中吲哚-3-丙酸荧光纳米传感器的研究。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2026-05-02 DOI: 10.1002/adhm.202503434

Mervin Chun-Yi Ang, Jonathan Wei Jie Lee, Sayyid Mohaideen, Gabriel Sánchez-Velázquez, Song Wang, Yangyang Han, Liu Lin, Germaine Yong, Raju Cheerlavancha, Duc Thinh Khong, Jianhong Ching, Sharon Hong Yu Han, Jun Yu Yeo, Lian Xu, Gajendra Pratap Singh, Michael S Strano

{"title":"Fluorescent Nanosensor for Indole-3-Propionic Acid Detection in Gut Health Monitoring.","authors":"Mervin Chun-Yi Ang, Jonathan Wei Jie Lee, Sayyid Mohaideen, Gabriel Sánchez-Velázquez, Song Wang, Yangyang Han, Liu Lin, Germaine Yong, Raju Cheerlavancha, Duc Thinh Khong, Jianhong Ching, Sharon Hong Yu Han, Jun Yu Yeo, Lian Xu, Gajendra Pratap Singh, Michael S Strano","doi":"10.1002/adhm.202503434","DOIUrl":"https://doi.org/10.1002/adhm.202503434","url":null,"abstract":"The gut microbiota plays a pivotal role in bio-transforming dietary components, including tryptophan, an essential amino acid that undergoes microbial metabolism. Microbial metabolism of tryptophan yields indole-3-propionic acid (IPA), an emerging biomarker for gut inflammation. Current IPA detection relies on expensive, time-consuming mass spectrometry. To address this limitation, a fluorescent nanosensor system is presented that uniquely features two optical modalities: one utilizing near-infrared (NIR) emission of a central single-walled carbon nanotube (SWNT), and a separate, visible emission from the corona phase polymer, a cationic conjugated polyelectrolyte (CP3). Selective IPA molecular recognition occurs at the latter, but the binding is optically reported via quenching in both the visible and NIR emission channels. The two modalities provide complementary advantages: CP3-SWNTs' NIR channel enables detection in strongly scattering tissue environments due to reduced Rayleigh scattering at longer wavelengths. Conversely, CP3 visible channel facilitates future rapid, cost-effective point-of-care biological sample screening. Functionality of both modalities is maintained within a gelatin metacrylate hydrogel offering potential for future continuous in vivo monitoring of IPA dynamics. The sensor reveals significant differences in plasma IPA levels between healthy controls and patients with active gut inflammation: ulcerative colitis and Crohn's disease, highlighting its promise in rapid gut health assessment.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e03434"},"PeriodicalIF":9.6,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147808569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Tumor-Targeted Cascade Catalytic Nanoreactor for Microenvironment Remodeling and Photodynamic Immunotherapy. 用于微环境重塑和光动力免疫治疗的肿瘤靶向级联催化纳米反应器。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2026-04-30 DOI: 10.1002/adhm.71205

Xiang-Yu Ma, Ting Pan, Xiao-Kang Jin, Shi-Man Zhang, Xuan Zeng, Xian-Zheng Zhang

{"title":"A Tumor-Targeted Cascade Catalytic Nanoreactor for Microenvironment Remodeling and Photodynamic Immunotherapy.","authors":"Xiang-Yu Ma, Ting Pan, Xiao-Kang Jin, Shi-Man Zhang, Xuan Zeng, Xian-Zheng Zhang","doi":"10.1002/adhm.71205","DOIUrl":"https://doi.org/10.1002/adhm.71205","url":null,"abstract":"Hypoxia, glutathione (GSH) overexpression, and lactate accumulation within the solid tumor microenvironment severely constrain the efficacy of photocatalytic therapy. Here, we report a CD44-targeted cascade nanoplatform (CNMLH) constructed via layer-by-layer assembly to remodel this metabolic barrier. The platform features a hollow graphitic carbon nitride (CN) core, sequentially coated with an in situ grown MnO2 shell, an electrostatically adsorbed lactate oxidase (LOx) layer, and an outermost hyaluronic acid (HA) coating. Upon HA-mediated internalization, the outer coating degrades to release LOx, which selectively consumes lactate to produce H2O2. Subsequently, the exposed MnO2 shell scavenges endogenous GSH and converts the generated H2O2 into O2. This catalytic cascade effectively disrupts the tumor's antioxidant defense system and alleviates local hypoxia. Consequently, under subsequent light irradiation, the CN core overcomes the hypoxic restriction to efficiently generate reactive oxygen species (ROS), thereby triggering robust immunogenic cell death (ICD). Both in vitro and in vivo experimental results confirm that this metabolism-intervening strategy effectively reverses the immunosuppressive microenvironment while eliciting antitumor immune responses.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71205"},"PeriodicalIF":9.6,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147757928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-Targeted Nanotherapy Restores Redox Homeostasis and Suppresses Uterine Hypercontractility for Effective Preterm Birth Intervention. 双靶向纳米疗法恢复氧化还原稳态和抑制子宫过度收缩的有效早产干预。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2026-04-30 DOI: 10.1002/adhm.71198

Yige Tang, Yufeng Cheng, Hongmei Zhuo, Hongmei Wang, Yuying Mu, Jianxiang Zhang, Hongbo Qi, Juan Cheng

{"title":"Dual-Targeted Nanotherapy Restores Redox Homeostasis and Suppresses Uterine Hypercontractility for Effective Preterm Birth Intervention.","authors":"Yige Tang, Yufeng Cheng, Hongmei Zhuo, Hongmei Wang, Yuying Mu, Jianxiang Zhang, Hongbo Qi, Juan Cheng","doi":"10.1002/adhm.71198","DOIUrl":"https://doi.org/10.1002/adhm.71198","url":null,"abstract":"Preterm birth (PTB), defined as delivery between 28 and 37 weeks of gestation, is a leading cause of global neonatal mortality. Its pathogenesis is primarily driven by oxidative stress and inflammation, synergistically inducing calcium ion influx into uterine smooth muscle cells, triggering aberrant contractions and PTB. Current therapies primarily offer only symptom suppression without addressing the underlying etiology, highlighting an urgent need for targeted interventions. Herein, we develop TPT, a multi-bioactive, amphiphilic conjugate, which is synthesized through stepwise covalent conjugation of hydrophilic polyethylene glycol, a superoxide dismutase mimetic, and a hydrogen peroxide-scavenging/anti-inflammatory generating unit onto a molecular skeleton. TPT can self-assemble into a multifunctional nanotherapy (designated as TPT NP). In both in vitro and in vivo lipopolysaccharide-induced PTB models, TPT NP treatment significantly mitigates oxidative/inflammatory cascades, reduces calcium influx and apoptosis in uterine smooth muscle cells, and suppresses myometrial contractions, thereby effectively delaying PTB. Mechanistically, TPT NP restores redox homeostasis in lipopolysaccharide-induced PTB by reducing oxidative damage products and bolstering endogenous antioxidant defenses, while concurrently improving uteroplacental hemodynamics and attenuating uterine hypercontractility. Critically, in vivo evaluations demonstrate excellent safety profiles of TPT NP, with no adverse effects on maternal health and offspring development, underscoring its significant clinical translational potential.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71198"},"PeriodicalIF":9.6,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147757938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0