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Multifaceted Hydrogel Scaffolds: Bridging the Gap between Biomedical Needs and Environmental Sustainability (Adv. Healthcare Mater. 27/2024) 多元水凝胶支架：缩小生物医学需求与环境可持续性之间的差距（Adv.）
IF 1 2区 医学
Advanced Healthcare Materials Pub Date : 2024-10-28 DOI: 10.1002/adhm.202470170
Narsimha Mamidi, Fátima Franco De Silva, Alejandro Bedón Vacas, Javier Adonay Gutiérrez Gómez, Naomi Yael Montes Goo, Daniela Ruiz Mendoza, Rui L. Reis, Subhas C. Kundu
{"title":"Multifaceted Hydrogel Scaffolds: Bridging the Gap between Biomedical Needs and Environmental Sustainability (Adv. Healthcare Mater. 27/2024)","authors":"Narsimha Mamidi,&nbsp;Fátima Franco De Silva,&nbsp;Alejandro Bedón Vacas,&nbsp;Javier Adonay Gutiérrez Gómez,&nbsp;Naomi Yael Montes Goo,&nbsp;Daniela Ruiz Mendoza,&nbsp;Rui L. Reis,&nbsp;Subhas C. Kundu","doi":"10.1002/adhm.202470170","DOIUrl":"https://doi.org/10.1002/adhm.202470170","url":null,"abstract":"<p><b>Functional Hydrogels</b></p><p>Multifaceted hydrogels with protein-based mimics promote cell growth and diversify utility in healthcare, environmental remediation, and beyond. Their design is pivotal in promoting tissue repair and mitigating ecological contamination. In article 2401195, Narsimha Mamidi and co-workers explore their potential to bridge the gap between healthcare and environmental solutions.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"13 27","pages":""},"PeriodicalIF":10.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.202470170","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142541084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioconjugated Antibody-Trojan Immune Converter Enhance Cancer Immunotherapy with Minimized Toxicity by Programmed Two-Step Immunomodulation of Myeloid Cells (Adv. Healthcare Mater. 27/2024) 生物共轭抗体-特洛伊免疫转换器通过对髓系细胞进行程序化两步免疫调节，以最小的毒性增强癌症免疫疗法（Adv. Healthcare Mater.）
IF 1 2区 医学
Advanced Healthcare Materials Pub Date : 2024-10-28 DOI: 10.1002/adhm.202470171
Soyoung Park, Seung Mo Jin, Suhyeon Kim, Ju Hee Cho, JungHyub Hong, Yong-Soo Bae, Yong Taik Lim
{"title":"Bioconjugated Antibody-Trojan Immune Converter Enhance Cancer Immunotherapy with Minimized Toxicity by Programmed Two-Step Immunomodulation of Myeloid Cells (Adv. Healthcare Mater. 27/2024)","authors":"Soyoung Park,&nbsp;Seung Mo Jin,&nbsp;Suhyeon Kim,&nbsp;Ju Hee Cho,&nbsp;JungHyub Hong,&nbsp;Yong-Soo Bae,&nbsp;Yong Taik Lim","doi":"10.1002/adhm.202470171","DOIUrl":"https://doi.org/10.1002/adhm.202470171","url":null,"abstract":"<p><b>Antibody-Trojan Immune Converter</b></p><p>In article 2401270 by Yong Taik Lim and co-worker, a programmed two-step activation strategy is suggested to enhance cancer immunotherapy with minimized systemic toxicities via Antibody-Trojan Immune Converter Conjugates that specifically targets myeloid cells by anti-SIRPα followed by reactivation of transiently inactivated Trojan TLR7/8 agonist after antibody-mediated endocytosis.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"13 27","pages":""},"PeriodicalIF":10.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.202470171","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142540965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Imaging-Based Efficacy Evaluation of Cancer Immunotherapy in Engineered Tumor Platforms and Tumor Organoids (Adv. Healthcare Mater. 27/2024) 基于成像的工程肿瘤平台和肿瘤有器官组织中的癌症免疫疗法疗效评估（Adv. Healthcare Mater.）
IF 1 2区 医学
Advanced Healthcare Materials Pub Date : 2024-10-28 DOI: 10.1002/adhm.202470168
Seong-Eun Kim, Suji Yun, Junsang Doh, Hong Nam Kim
{"title":"Imaging-Based Efficacy Evaluation of Cancer Immunotherapy in Engineered Tumor Platforms and Tumor Organoids (Adv. Healthcare Mater. 27/2024)","authors":"Seong-Eun Kim,&nbsp;Suji Yun,&nbsp;Junsang Doh,&nbsp;Hong Nam Kim","doi":"10.1002/adhm.202470168","DOIUrl":"https://doi.org/10.1002/adhm.202470168","url":null,"abstract":"<p><b>Cancer Immunotherapy</b></p><p>In article 2400475 Junsang Doh, Hong Nam Kim, and co-workers summarize recent advances of imaging-based efficacy evaluation methodologies of cancer immunotherapy by using engineered tumor models. The imaging-based cancer immunotherapy evaluation platform facilitates systematic assessment of treatments through suitable in vitro models that closely mimic the human immune system. These evaluation methods enable a more precise and personalized approach in the development of cancer immunotherapy.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"13 27","pages":""},"PeriodicalIF":10.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.202470168","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142541081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineering Nanoclusters of Cell Adhesive Ligands on Biomaterial Surfaces: Superior Cell Proliferation and Myotube Formation for Skeletal Muscle Tissue Regeneration. 生物材料表面的细胞粘附配体纳米团簇工程：用于骨骼肌组织再生的卓越细胞增殖和肌管形成。
IF 1 2区 医学
Advanced Healthcare Materials Pub Date : 2024-10-28 DOI: 10.1002/adhm.202402991
Shirin Nour, Sadegh Shabani, Kristy Swiderski, Gordon S Lynch, Andrea J O'Connor, Greg Qiao, Daniel E Heath
{"title":"Engineering Nanoclusters of Cell Adhesive Ligands on Biomaterial Surfaces: Superior Cell Proliferation and Myotube Formation for Skeletal Muscle Tissue Regeneration.","authors":"Shirin Nour, Sadegh Shabani, Kristy Swiderski, Gordon S Lynch, Andrea J O'Connor, Greg Qiao, Daniel E Heath","doi":"10.1002/adhm.202402991","DOIUrl":"https://doi.org/10.1002/adhm.202402991","url":null,"abstract":"<p><p>Engineering biointerfaces with nanoscale clustering of integrin-binding cell adhesive peptides is critical for promoting receptor redistribution into signaling complexes. Skeletal muscle cells are exquisitely sensitive to integrin-mediated signaling, yet biomaterials supporting myogenesis through control of the density and nanodistribution of ligands have not been developed. Here, materials are developed with tailorable cell adhesive ligands distribution at the interface by independently controlling their global and local density to enhance myogenesis, by promoting myoblast growth and myotube formation. To this end, RGD-functionalized low-fouling polymer surfaces with global ligand densities (G) from 0-7 µg peptide/mg polymer and average local ligand densities (L) from 1-6.3 ligands/cluster, are generated and characterized. Cell studies demonstrate improvements in cell adhesion, spreading, growth, and myotube formation up to a density of 7 µg peptide/mg polymer with 4 ligands/cluster. Optimizing ligand density and distribution also promotes early myofiber maturation, identified by increased MF20 marker protein expression and sarcomere-forming myotubes. At higher ligand densities, these cell properties are decreased, indicating that ligand multivalency is a critical parameter for tailoring cell-material interactions, to a certain threshold. The findings provide new insights for designing next-generation biomaterials and hold promise for improved engineering of skeletal muscle.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2402991"},"PeriodicalIF":10.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142491368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improvement of Therapeutic Effect via Inducing Non-Apoptotic Cell Death Using mRNA-Protection Nanocage (Adv. Healthcare Mater. 27/2024) 利用 mRNA 保护纳米笼诱导细胞非凋亡以提高疗效（Adv. Healthcare Mater. 27/2024）
IF 1 2区 医学
Advanced Healthcare Materials Pub Date : 2024-10-28 DOI: 10.1002/adhm.202470172
Seoyoung Kim, Seongchan Kim, Sojin Kim, Nan-Ee Lee, Soo-Hwan Lee, Hyunkyung Kim, Hyojin Lee
{"title":"Improvement of Therapeutic Effect via Inducing Non-Apoptotic Cell Death Using mRNA-Protection Nanocage (Adv. Healthcare Mater. 27/2024)","authors":"Seoyoung Kim,&nbsp;Seongchan Kim,&nbsp;Sojin Kim,&nbsp;Nan-Ee Lee,&nbsp;Soo-Hwan Lee,&nbsp;Hyunkyung Kim,&nbsp;Hyojin Lee","doi":"10.1002/adhm.202470172","DOIUrl":"https://doi.org/10.1002/adhm.202470172","url":null,"abstract":"<p><b>mRNA-Protective Nanocage</b></p><p>Necroptosis-induced mRNA expression with nanocage led to significant tumor suppression and immune cell infiltration in vivo model, highlighting the potential of mRNA and nanotechnology-based therapeutics in various diseases including cancer with drug resistance. More details can be found in article 2400240 by Hyunkyung Kim, Hyojin Lee, and co-workers.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"13 27","pages":""},"PeriodicalIF":10.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.202470172","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142540964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioinspired Genetic and Chemical Engineering of Protein Hydrogels for Programable Multi-Responsive Actuation (Adv. Healthcare Mater. 27/2024) 蛋白质水凝胶的生物启发遗传和化学工程，实现可编程多响应致动（Adv. Healthcare Mater.）
IF 1 2区 医学
Advanced Healthcare Materials Pub Date : 2024-10-28 DOI: 10.1002/adhm.202470175
Ting Ji, Haoyuan Shi, Xinyi Yang, Hu Li, David L Kaplan, Jingjie Yeo, Wenwen Huang
{"title":"Bioinspired Genetic and Chemical Engineering of Protein Hydrogels for Programable Multi-Responsive Actuation (Adv. Healthcare Mater. 27/2024)","authors":"Ting Ji,&nbsp;Haoyuan Shi,&nbsp;Xinyi Yang,&nbsp;Hu Li,&nbsp;David L Kaplan,&nbsp;Jingjie Yeo,&nbsp;Wenwen Huang","doi":"10.1002/adhm.202470175","DOIUrl":"https://doi.org/10.1002/adhm.202470175","url":null,"abstract":"<p><b>Programmable Protein Actuators</b></p><p>In article 2401562, Wenwen Huang and co-workers develop a bioinspired strategy that synergistically combines genetic and chemical engineering approaches to program biological hydrogel actuators. Current work offers a more versatile and bio-friendly platform for the de novo design of protein actuators, toward biomimetic living materials.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"13 27","pages":""},"PeriodicalIF":10.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.202470175","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142540997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maturation of Human iPSC-Derived Cardiac Microfiber with Electrical Stimulation Device (Adv. Healthcare Mater. 27/2024) 利用电刺激装置使人类 iPSC 衍生的心脏微纤维成熟（Adv. Healthcare Mater. 27/2024）
IF 1 2区 医学
Advanced Healthcare Materials Pub Date : 2024-10-28 DOI: 10.1002/adhm.202470167
Akari Masuda, Yuta Kurashina, Hidenori Tani, Yusuke Soma, Jumpei Muramatsu, Shun Itai, Shugo Tohyama, Hiroaki Onoe
{"title":"Maturation of Human iPSC-Derived Cardiac Microfiber with Electrical Stimulation Device (Adv. Healthcare Mater. 27/2024)","authors":"Akari Masuda,&nbsp;Yuta Kurashina,&nbsp;Hidenori Tani,&nbsp;Yusuke Soma,&nbsp;Jumpei Muramatsu,&nbsp;Shun Itai,&nbsp;Shugo Tohyama,&nbsp;Hiroaki Onoe","doi":"10.1002/adhm.202470167","DOIUrl":"https://doi.org/10.1002/adhm.202470167","url":null,"abstract":"<p><b>In Vitro Cardiac Tissue</b></p><p>An electrical stimulation system for maturing hiPSC-derived microfiber-shaped cardiac tissue (cardiac microfibers: CMFs) is proposed. CMFs under electrical stimulation with different frequencies are examined to evaluate the maturation levels by their sarcomere lengths, electrophysiological characteristics, and gene expression. This model will contribute to the pathological research of unexplained cardiac diseases and pharmacologic testing. More details can be found in article 2303477 by Shugo Tohyama, Hiroaki Onoe, and co-workers.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"13 27","pages":""},"PeriodicalIF":10.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.202470167","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142541080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Masthead: (Adv. Healthcare Mater. 27/2024) 刊头：（Adv. Healthcare Mater.）
IF 1 2区 医学
Advanced Healthcare Materials Pub Date : 2024-10-28 DOI: 10.1002/adhm.202470169
{"title":"Masthead: (Adv. Healthcare Mater. 27/2024)","authors":"","doi":"10.1002/adhm.202470169","DOIUrl":"https://doi.org/10.1002/adhm.202470169","url":null,"abstract":"","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"13 27","pages":""},"PeriodicalIF":10.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.202470169","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142541082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microenvironment-Responsive Targeted Nanomedicine for a Collaborative Integration of Tumor Theranostics and Bone Defect Repair (Adv. Healthcare Mater. 27/2024) 微环境响应型靶向纳米药物实现肿瘤血清学与骨缺损修复的协同整合（Adv. Healthcare Mater. 27/2024）
IF 1 2区 医学
Advanced Healthcare Materials Pub Date : 2024-10-28 DOI: 10.1002/adhm.202470174
Wenxuan Wang, Weiwei Kang, Xin Zhang, Xiaochun Zheng, Yarong Jin, Zhuo Ma, Yuhang Wang, Rong Dai, Xun Ma, Ziliang Zheng, Ruiping Zhang
{"title":"Microenvironment-Responsive Targeted Nanomedicine for a Collaborative Integration of Tumor Theranostics and Bone Defect Repair (Adv. Healthcare Mater. 27/2024)","authors":"Wenxuan Wang,&nbsp;Weiwei Kang,&nbsp;Xin Zhang,&nbsp;Xiaochun Zheng,&nbsp;Yarong Jin,&nbsp;Zhuo Ma,&nbsp;Yuhang Wang,&nbsp;Rong Dai,&nbsp;Xun Ma,&nbsp;Ziliang Zheng,&nbsp;Ruiping Zhang","doi":"10.1002/adhm.202470174","DOIUrl":"https://doi.org/10.1002/adhm.202470174","url":null,"abstract":"<p><b>Breast Cancer Bone Metastases</b></p><p>A microenvironment-responsive targeted nanomedicine enables a unique combination of tumor theranostics and bone defect repair. With excellent bone binding and regeneration properties, it offers a highly effective tumor treatment strategy, presenting a new paradigm for the theranostics of breast cancer bone metastasis. More details can be found in article 2400715 by Xun Ma, Ziliang Zheng, Ruiping Zhang, and co-workers.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"13 27","pages":""},"PeriodicalIF":10.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.202470174","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142540996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing Two-Photon Photodynamic Therapy Over NIR-II Excitable Conjugated Microporous Polymer with NIR-I Emission. 通过近红外-I 发射的近红外-II 可激发共轭微孔聚合物推进双光子光动力疗法。
IF 1 2区 医学
Advanced Healthcare Materials Pub Date : 2024-10-26 DOI: 10.1002/adhm.202402274
Bo Li, Xinlei Yu, Xin Lu, Xianshun Sun, Yuanzhong Kai, Longjiu Cheng, Hongping Zhou, Yupeng Tian, Dandan Li
{"title":"Advancing Two-Photon Photodynamic Therapy Over NIR-II Excitable Conjugated Microporous Polymer with NIR-I Emission.","authors":"Bo Li, Xinlei Yu, Xin Lu, Xianshun Sun, Yuanzhong Kai, Longjiu Cheng, Hongping Zhou, Yupeng Tian, Dandan Li","doi":"10.1002/adhm.202402274","DOIUrl":"https://doi.org/10.1002/adhm.202402274","url":null,"abstract":"<p><p>The availability of second near-infrared (NIR-II) excitable two-photon photosensitizers with NIR-I emission for efficient photodynamic therapy (PDT) is limited by challenges in molecular design. In this study, a NIR-II light-excitable two-photon conjugated microporous polymer (Tph-Dbd) with emission in the NIR-I region is developed. The large conjugated system and delocalized electronic structures endow Tph-Dbd with a large two-photon absorption cross-section under NIR-II light excitation. Moreover, the efficient electron acceptor and donor units within the π-conjugated backbones result in NIR-I emission for high signal-to-background ratio imaging, as well as separated highest occupied molecular orbital and lowest unoccupied molecular orbital distributions for excellent singlet oxygen generation ability. The excellent NIR-II excitable two-photon absorption activity, NIR-I emission, good biocompatibility, and high photostability allow Tph-Dbd to be used for efficient in vitro fluorescence imaging guided PDT. Moreover, the impressive photothermal effect of Tph-Dbd can overcome the limitations of PDT in the treatment of hypoxic tumors. This study highlights a strategy for designing NIR-II excitable two-photon photosensitizers for advanced PDT.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2402274"},"PeriodicalIF":10.0,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142491358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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