Advanced Healthcare Materials最新文献_第10页

All-In-One Magnetic Nanoparticles for Thermo-Immunotherapy of Malignant Melanoma.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-03-04 DOI: 10.1002/adhm.202500260

Masahiro Kaneko, Rintaro Saito, Ami Nishikawa, Akira Ito

{"title":"All-In-One Magnetic Nanoparticles for Thermo-Immunotherapy of Malignant Melanoma.","authors":"Masahiro Kaneko, Rintaro Saito, Ami Nishikawa, Akira Ito","doi":"10.1002/adhm.202500260","DOIUrl":"https://doi.org/10.1002/adhm.202500260","url":null,"abstract":"Hyperthermia using magnetic nanoparticles is a promising cancer therapy that locally destroys tumors and induces antitumor immunity by releasing tumor antigens from dying cells. However, magnetic hyperthermia in malignant melanomas with poor immunogenicity and an immunosuppressive microenvironment remains challenging. Here, all-in-one magnetic nanoparticles (αPD-L1/CpG@MCL) are developed for thermo-immunotherapy that enables hyperthermia with magnetic nanoparticles and immunotherapy with anti-PD-L1 antibody and CpG to improve the immunosuppressive tumor microenvironment. Magnetic hyperthermia with magnetite cationic liposomes (MCL, without anti-PD-L1 antibody and CpG) inhibits tumor growth in B16F10 melanoma; however, complete tumor regression is not observed. In contrast, complete tumor regression is observed when mice are treated with thermo-immunotherapy using αPD-L1/CpG@MCL. Additionally, mice cured after magnetic hyperthermia with αPD-L1/CpG@MCL rejected rechallenge with B16F10 cells, and cytotoxicity assay using splenocytes from cured mice shows the induction of antitumor immunity against B16F10 cells. Analysis of tumor-infiltrating lymphocytes reveals that magnetic hyperthermia with αPD-L1/CpG@MCL increased CD8+ T lymphocytes and M1-like macrophages, and decreased M2-like macrophages, indicating an improvement in the tumor microenvironment. This study provides a key design strategy for all-in-one magnetic nanoparticles that could cure malignant melanomas.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2500260"},"PeriodicalIF":10.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microenvironment-Regulated Hydrogels Prepared with a Brand-New Small Molecule Cross-Linker for Stepwise Treatment of Myocardial Infarction.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-03-04 DOI: 10.1002/adhm.202500804

Yu Wu, Wen Zhang, Linlin Huang, Xinping Xu, Shuyi He, Zhicun Wang, Wenqi Liu, Ya Yao, Li Yang, Cheng Hu, Yunbing Wang

{"title":"Microenvironment-Regulated Hydrogels Prepared with a Brand-New Small Molecule Cross-Linker for Stepwise Treatment of Myocardial Infarction.","authors":"Yu Wu, Wen Zhang, Linlin Huang, Xinping Xu, Shuyi He, Zhicun Wang, Wenqi Liu, Ya Yao, Li Yang, Cheng Hu, Yunbing Wang","doi":"10.1002/adhm.202500804","DOIUrl":"https://doi.org/10.1002/adhm.202500804","url":null,"abstract":"Despite the development of many injectable hydrogels intended for the repair of myocardial infarction (MI), their effectiveness is often compromised because they target merely one or two phases of MI's pathological progression. Here, a multifunctional hydrogel delivery platform is prepared with a brand-new small molecule cross-linker for stepwise treatment of MI. The synthesis and reporting of a novel small-molecule phenylboronic acid cross-linker ((N(BA)3)) with a precise molecular structure is conducted for the first time, and it is successfully utilized with polyvinyl alcohol (PVA) dopamine to prepare a hydrogel with infarct microenvironmental responsiveness and anti-oxidant. Further, considering the multistage of MI repair, hydrogel contains both hyperoside bioactive nanoparticles (EGCG@Hyp&Arg NPs) and PLGA microspheres loaded with galunisertib (PLGA@Gal Ms). The EGCG@Hyp&Arg NPs are rapidly released and demonstrate anti-inflammatory and pro-angiogenesis effects, while in the long term, Gal is released from the PLGA@Gal Ms to inhibit myocardial fibrosis and improve cardiac function. Results from both in vitro and in vivo studies reveal that the hydrogel is engineered with programmed capabilities for anti-oxidation, reducing inflammation, promoting new blood vessel formation, and inhibiting fibrosis, thereby significantly enhancing heart function post-MI. Overall, this multifunctional hydrogel delivery platform has great potential for application as a therapeutic strategy for MI.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2500804"},"PeriodicalIF":10.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Actuating Extracellular Matrices Decouple the Mechanical and Biochemical Effects of Muscle Contraction on Motor Neurons (Adv. Healthcare Mater. 6/2025) 致动细胞外基质使肌肉收缩对运动神经元的机械效应和生化效应分离（Adv. Healthcare Mater.）

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-03-03 DOI: 10.1002/adhm.202570032

Angel Bu, Ferdows Afghah, Nicolas Castro, Maheera Bawa, Sonika Kohli, Karina Shah, Brandon Rios, Vincent Butty, Ritu Raman

引用次数: 0

Issue Information: Adv. Healthcare Mater. 6/2025 发行信息：Adv.6/2025

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-03-03 DOI: 10.1002/adhm.202570034

引用次数: 0

Dual-Functional Hafnium Oxide Nanoplatform Combining High-Z Radiosensitization With Bcl-2 Gene Silencing for Enhanced Cancer Radiotherapy.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-03-03 DOI: 10.1002/adhm.202404819

Seungyong Shin, Ga-Hyun Bae, Jun-Hyeok Han, Ha Eun Shin, Joo Dong Park, Seunghyo Ko, Eun-Young Koh, Jieun Han, Su Chul Han, Jason Joon Bock Lee, Dong-Hyun Kim, Heerim Nam, Wooram Park

{"title":"Dual-Functional Hafnium Oxide Nanoplatform Combining High-Z Radiosensitization With Bcl-2 Gene Silencing for Enhanced Cancer Radiotherapy.","authors":"Seungyong Shin, Ga-Hyun Bae, Jun-Hyeok Han, Ha Eun Shin, Joo Dong Park, Seunghyo Ko, Eun-Young Koh, Jieun Han, Su Chul Han, Jason Joon Bock Lee, Dong-Hyun Kim, Heerim Nam, Wooram Park","doi":"10.1002/adhm.202404819","DOIUrl":"https://doi.org/10.1002/adhm.202404819","url":null,"abstract":"The efficacy of radiotherapy is often limited by insufficient radiosensitization and tumor radioresistance. This study reports a dual-functional hafnium oxide nanoplatform that combines high-Z radiosensitization with Bcl-2 gene silencing for enhanced cancer radiotherapy. The nanoplatform is developed by surface modification of hafnium oxide nanoparticles with polyethyleneimine, enabling efficient siRNA delivery while maintaining inherent high-Z radiosensitizing properties. Comprehensive physicochemical characterization confirmed the successful surface modification and stable siRNA complexation. Upon radiation exposure, the nanoplatform enhanced reactive oxygen species generation and DNA damage while simultaneously delivering Bcl-2 siRNA to suppress radioresistance mechanisms. In vitro studies revealed significant enhancement of radiation-induced cell death through synergistic effects of high-Z radiosensitization and Bcl-2 silencing, evidenced by increased γ-H2AX expression and apoptotic cell population. In a murine colon cancer model, the nanoplatform achieved remarkable tumor growth inhibition (80%) when combined with radiotherapy while exhibiting favorable biocompatibility in major organs. Mechanistic studies confirmed effective Bcl-2 downregulation and enhanced DNA damage in tumor tissues, validating this dual-functional therapeutic approach. This study presents a promising strategy for improving radiotherapy outcomes through the simultaneous enhancement of radiosensitization and suppression of radioresistance, potentially advancing the field of cancer radiotherapy.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2404819"},"PeriodicalIF":10.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Minimally Invasive Syringe-Injectable Hydrogel with Angiogenic Factors for Ischemic Stroke Treatment (Adv. Healthcare Mater. 6/2025)

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-03-03 DOI: 10.1002/adhm.202570037

Donggue Kim, Ji Woo Lee, Yang Tae Kim, Junhyeok Choe, Gaeun Kim, Chang Man Ha, Jae Geun Kim, Kwang Hoon Song, Sunggu Yang

引用次数: 0

Dual Functional Radioactive Gel-Microspheres for Combinatorial Radioembolization and Photothermal Therapy of Hepatocellular Carcinoma.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-03-03 DOI: 10.1002/adhm.202401057

Jing Sun, Xingwei Sun, Liang Yin, Shuo Jin, Qian Huang, Yi Dong, Xiaolei Gu, Yujuan Zhang, Yong Jin, Ran Zhu, Guanglin Wang

{"title":"Dual Functional Radioactive Gel-Microspheres for Combinatorial Radioembolization and Photothermal Therapy of Hepatocellular Carcinoma.","authors":"Jing Sun, Xingwei Sun, Liang Yin, Shuo Jin, Qian Huang, Yi Dong, Xiaolei Gu, Yujuan Zhang, Yong Jin, Ran Zhu, Guanglin Wang","doi":"10.1002/adhm.202401057","DOIUrl":"https://doi.org/10.1002/adhm.202401057","url":null,"abstract":"Transarterial radioembolization (TARE) is an established clinical therapy for treating patients with intermediate to advanced hepatocellular carcinoma (HCC) or those who cannot undergo radical treatment. However, the delivery of a high radiation dose is associated with several adverse effects, such as radiation pneumonitis. Additionally, the available radioactive microspheres (MSs) are dense and unsuitable for interventional delivery. This study proposes the use of commercial CalliSpheres polyvinyl alcohol (PVA) gel MSs coated with polydopamine (PDA) as a carrier for radioactive iodine (131I) labeled using the iodogen method, denoted as 131I-PDA@PVA MSs, which can be for radioembolization combined photothermal therapy (PTT) of HCC. In vitro experiments have demonstrated that 131I-PDA@PVA MSs have high radiolabeling stability and photothermal properties. Single photon emission computed tomography (SPECT)/computed tomography (CT) imaging and biodistribution experiments have shown that 131I-PDA@PVA MSs remain stable in vivo without any radioactive leakage. The results of the antitumor study suggest that 131I-PDA@PVA MSs are an effective treatment for inhibiting tumor growth through a combination of radioembolization and PTT while avoiding significant side effects. These multifunctional MSs have great potential for clinical application in the treatment of HCC.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2401057"},"PeriodicalIF":10.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Porous PtCu Alloys Decode Plasma Metabolic Fingerprints for the Recognition of Severe Community-Acquired Pneumonia.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-03-03 DOI: 10.1002/adhm.202403733

Kexin Meng, Yao Shen, Dongni Hou, Hanbing Hu, Shouzhi Yang, Ziyue Zhang, Ayizekeranmu Yiming, Dingyitai Liang, Weibin Tian, Ludan He, Shuoyan Wei, Ying Wang, Jie Shen, Yuanlin Song, Sai Gu, Haiyang Su, Jian Zhou, Kun Qian

{"title":"Porous PtCu Alloys Decode Plasma Metabolic Fingerprints for the Recognition of Severe Community-Acquired Pneumonia.","authors":"Kexin Meng, Yao Shen, Dongni Hou, Hanbing Hu, Shouzhi Yang, Ziyue Zhang, Ayizekeranmu Yiming, Dingyitai Liang, Weibin Tian, Ludan He, Shuoyan Wei, Ying Wang, Jie Shen, Yuanlin Song, Sai Gu, Haiyang Su, Jian Zhou, Kun Qian","doi":"10.1002/adhm.202403733","DOIUrl":"https://doi.org/10.1002/adhm.202403733","url":null,"abstract":"Rapid and accurate recognition of severe community-acquired pneumonia (CAP) would facilitate the optimal intervention. Currently, the diagnosis of severe CAP is commonly based on the criteria established by Infectious Disease Society of America (IDSA)/American Thoracic Society (ATS), which include 2 primary and 9 secondary criteria, making the process cumbersome and time-consuming. Here, a porous PtCu alloy-assisted laser desorption/ionization mass spectrometry (LDI MS) is designed for the extraction of plasma metabolic fingerprints (PMFs), coupling with machine learning for the diagnosis of severe CAP. The PtCu alloys with optimal particle size exhibit excellent sensitivity, reproducibility, and universality for metabolite detection, due to the porous structure, promising photoelectric effect, and improved melting surface structure. Further, the nanoplatform successfully records the PMFs within seconds, using only 0.5 µL native plasma. Machine learning of PMFs on 69 individuals produces a diagnostic model with an area under curve (AUC) of 0.832. Particularly, a three metabolic biomarker panel demonstrates enhanced diagnostic efficiency (AUC of 0.846), outperforming reported biomarkers (AUC of 0.560-0.770). Notably, the diagnosis can be completed in ≈35 min. The work affords a rapid and precise method for CAP management through metabolite analysis.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403733"},"PeriodicalIF":10.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Injectable Glucose-Releasing Microgels Enhance the Survival and Therapeutic Potential of Transplanted MSCs Under Ischemic Conditions (Adv. Healthcare Mater. 6/2025)

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-03-03 DOI: 10.1002/adhm.202570038

Chieh-Cheng Huang, Chun-Kai Chang, Pei-Ching Yang, Han Chiu, Shih-Heng Chen, Li-Wen Hsu

引用次数: 0

Cerium Dioxide Nanoparticles-Based Inspector Enhances Mitochondrial Quality Control to Maintain Chondrocyte Homeostasis in Osteoarthritis Therapy.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-03-03 DOI: 10.1002/adhm.202405069

Li Chen, Jianye Yang, Zhengwei Cai, Yanran Huang, Qinyang Zhang, Chengqiang Zhou, Juan Wang, Wei Huang, Wenguo Cui, Ning Hu

{"title":"Cerium Dioxide Nanoparticles-Based Inspector Enhances Mitochondrial Quality Control to Maintain Chondrocyte Homeostasis in Osteoarthritis Therapy.","authors":"Li Chen, Jianye Yang, Zhengwei Cai, Yanran Huang, Qinyang Zhang, Chengqiang Zhou, Juan Wang, Wei Huang, Wenguo Cui, Ning Hu","doi":"10.1002/adhm.202405069","DOIUrl":"https://doi.org/10.1002/adhm.202405069","url":null,"abstract":"Imbalanced mitochondrial quality control is strongly linked to the onset and development of osteoarthritis (OA). However, current research primarily focuses on local cartilage repair and phenotype maintenance, lacking a systematic approach to subcellular mitochondrial quality control. To address this, the present study proposes a mitochondrial quality control strategy based on nanozyme hydrogel microspheres (\"mitochondrial inspector\"), constructed through electrostatic self-assembly, incorporation of dynamic diselenide bonds, and microfluidic technology. The mitochondrial oxidative stress microenvironment is improved by cerium dioxide nanoparticles and combined with metformin to activate autophagy to clear persistently dysfunctional mitochondria, thereby inhibiting OA progression. In vitro results showed that \"mitochondrial inspector\" not only significantly improved the oxidative stress microenvironment of chondrocytes, but also efficiently scavenged the damaged mitochondria, increased the mitochondrial membrane potential by over 20-fold, and notably improved the mitochondrial function and chondrocyte homeostasis. In a rat OA model, minimally invasive intra-articular injection of the \"mitochondrial inspector\" effectively regulated mitochondrial quality, alleviated cartilage matrix degradation, reduced osteophyte formation by ≈80%, and reduced the Mankin score for cartilage damage by over 70%. In summary, this study presents a novel nanozyme microsphere-based mitochondrial quality control strategy for the treatment of OA, providing new insights for subcellular therapies for other aging-related diseases.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2405069"},"PeriodicalIF":10.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0