Advanced Healthcare Materials最新文献

{"title":"Well-Aligned Hierarchical Design of High Strength Anisotropic Chitosan Fibers by Electrostatic Regulation for Absorbable Sutures","authors":"Jingxian Zhang,&nbsp;Di Hu,&nbsp;Xiao Yu,&nbsp;Mengyi Liu,&nbsp;Fangjiu He,&nbsp;Yanfeng Wang,&nbsp;Xiaowen Shi","doi":"10.1002/adhm.202504530","DOIUrl":"10.1002/adhm.202504530","url":null,"abstract":"<div>\u0000 \u0000 <p>Chitosan fibers prepared by conventional wet-spinning methods result in significantly compromised wet-state mechanical strength, attributed to hydrogen bonding that hinders molecular chain alignment. To address this critical challenge, this study develops an electrostatically regulated sacrificial micelle-assisted alignment strategy to fabricate high-performance anisotropic chitosan fibers for absorbable sutures. Utilizing sodium dodecyl sulfate (SDS) micelles, electrostatic regulation disrupts intermolecular hydrogen bonds in chitosan, enables uniaxial chain alignment during drawing, and reconstructs a dense hydrogen-bonded network upon micelle removal with NaOH. The resulting pure chitosan fibers (Chit⁰) exhibit exceptional mechanical properties, achieving a dry tensile strength of 293.6 ± 31.0 MPa and retaining 105.0 ± 17.2 MPa under wet conditions—significantly surpassing conventional wet-spun chitosan fibers. Microscopically, the fibers exhibit aligned aggregates with reduced d-spacings, effectively enhancing mechanical properties. The fibers demonstrate outstanding cytocompatibility, negligible in vivo inflammatory response, and controllable degradation kinetics (44% strength retention after 2-week implantation). Animal experiments confirm accelerated wound healing with minimal scarring, outperforming commercial poly(glycolic acid) sutures in biocompatibility. This strategy offers a versatile paradigm for engineering anisotropic biopolymer fibers with balanced wet-strength and biofunctionality.</p>\u0000 </div>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 13","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145987442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin-Interfaced Therapeutic Patches for Wound Fluid Management and Transdermal Drug Delivery","authors":"Dongjun Han,&nbsp;Donghyun Kim,&nbsp;Haram Lee,&nbsp;Dong-Wook Park,&nbsp;Sung Soo Kwak,&nbsp;Joohee Kim","doi":"10.1002/adhm.202504450","DOIUrl":"10.1002/adhm.202504450","url":null,"abstract":"<p>Delayed or non-healing wounds remain a considerable medical challenge owing to infection-related complications. Consequently, promoting wound healing through effective dressings and transdermal drug delivery systems is crucial. However, current approaches are hindered by complex drug formulations or dependence on bulky external equipment, limiting their practicability and patient convenience. To overcome these limitations, this study presents a skin-interfaced therapeutic patch that integrates wound fluid management with a transdermal drug delivery system. The wound fluid management component consists of a microfluidic channel and a chamber combined with a hydrogel film, which collects and preserves wound fluid rich in wound-healing factors, thereby maintaining optimal hydration and providing a protective barrier. The transdermal drug delivery system utilizes an iontophoresis module incorporating bio-derived DNA polymers that promote tissue regeneration, enabling the direct and efficient delivery of therapeutic agents through the skin. The multifunctional patch is validated via in vitro and in vivo studies, thereby demonstrating accelerated and robust tissue regeneration.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 13","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13058775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145626981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spherical Skin Model: Stratified Co-Culture of Fibroblasts and Keratinocytes on Spherical Beads Toward Compound Screening","authors":"Elisa Lenzi,&nbsp;Nadia Vertti-Quintero,&nbsp;Julien Husson,&nbsp;Anne-Laure Bulteau,&nbsp;Carine Nizard,&nbsp;Karl Pays,&nbsp;Sébastien Sart,&nbsp;Charles N. Baroud","doi":"10.1002/adhm.202503250","DOIUrl":"10.1002/adhm.202503250","url":null,"abstract":"<p>Advanced skin models are critical for pursuing non-animal approaches in drug and cosmetic testing. However, existing 3D models remain complex and time-consuming, which limits their adoption. Spherical skin model (SSM) is presented, a platform that balances biological fidelity with experimental robustness. The SSM is based on a core–shell structure where the dermal core is modeled by embedding human fibroblasts into collagen microcarriers (150 <span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 <mi>μ</mi>\u0000 <mi>m</mi>\u0000 </mrow>\u0000 <annotation>$mu{rm m}$</annotation>\u0000 </semantics></math>), while the epidermal shell is formed by outer layers of immortalized keratinocytes. The collagen beads are generated using droplet microfluidics to enable rapid and reproducible production. The biological relevance of SSM is revealed through elevated expression of epidermal differentiation markers (loricrin, involucrin, keratin 1, keratin 10) and the dermal–epidermal junction marker collagen VII. The barrier function is validated by permeability assays that show strong exclusion of fluorescent dextran above 4 kDa. Moreover, their usefulness for screening is shown by identifying a dose-dependent effect of vitamins in reducing oxidative stress and apoptosis against tert-butyl hydroperoxide. As such, this 3D microphysiological model recapitulates key structural, molecular, and functional features of human skin while offering rapid generation, scalability, and compatibility with high-throughput applications in dermatological and cosmetic research.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 13","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13058795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145740238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell Membrane Biomimetic Drug Delivery Systems Based on Ferroptosis Mechanism for Anticancer Treatment","authors":"Li Su,&nbsp;Shuoye Yang,&nbsp;Huajian Yuan,&nbsp;Qianqian Cheng,&nbsp;Xin Wang,&nbsp;Ning Li,&nbsp;Lu Zhang,&nbsp;Peng Li","doi":"10.1002/adhm.202504993","DOIUrl":"10.1002/adhm.202504993","url":null,"abstract":"<div>\u0000 \u0000 <p>Ferroptosis, a recently identified iron-dependent form of programmed cell death that is distinct from apoptosis, holds significant promise for the eradication of invasive malignant tumors that are resistant to conventional therapies. However, many ferroptosis inducers utilized in vivo face considerable challenges, including immune clearance, insufficient targeting, and poor biocompatibility. Biomimetic nanostructures derived from various cell membranes present a promising approach to address these issues and have emerged as a focal point of research. This paper reviews the latest advancements in biomimetic nanomaterials for ferroptosis-related tumor nanomedicine. First, it provides a concise overview of the definition, mechanisms, and inducers of ferroptosis while emphasizing the feasibility and characteristics associated with employing ferroptosis as a therapeutic strategy for cancer treatment. Subsequently, the paper introduces several representative biomimetic nanomedicines based on cell membranes—-specifically those derived from red blood cells, white blood cells, and cancer cells—while discussing their respective advantages and limitations. The review then focuses on combining ferroptosis induction by membrane-derived delivery systems with multimodal therapeutic strategies for oncological treatments. Finally, we explore the challenges and opportunities related to their practical implementation.</p>\u0000 </div>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 13","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145808873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of Time-Gated Luminescence and 19F Magnetic Resonance in Lanthanide Complexes-Based Probes for Quantitative Imaging of Mitochondrial Superoxide Anions","authors":"Xinyue Zhang,&nbsp;Deshu Kong,&nbsp;Bo Song,&nbsp;Yundi Huang,&nbsp;Jingli Yuan","doi":"10.1002/adhm.202505101","DOIUrl":"10.1002/adhm.202505101","url":null,"abstract":"<div>\u0000 \u0000 <p>Time-gated luminescence (TGL) bioimaging offers high-sensitivity biosensing with background-free characteristics, yet its limited tissue penetration constrains broad in vivo applications. To address this issue, we developed unique lanthanide complexes to act as modular probes that integrate the high-sensitivity of TGL and deep-tissue imaging capability of ¹⁹F magnetic resonance (MR). The probes are constructed from a multifunctional ligand, Mito-BOTTA, comprising a mitochondria-targeting 1-(2-aminoethyl)-4-methylpyridinium group, a superoxide anion (O₂^•−)-responsive 3,5-bis(trifluoromethyl)benzenesulfonyl (TFBS) moiety, and a terpyridine polyacid-derived scaffold for coordination to Eu³⁺, Tb³⁺, or Gd³⁺. The coordination with Eu³⁺/Tb³⁺-mixture produces a ratiometric TGL probe Mito-BOTTA-Eu³⁺/Tb³⁺ that, upon O₂^•−-triggered cleavage of the TFBS moiety, exhibits a pronounced increase in Tb³⁺ emission at 538 nm, accompanied by a decrease in Eu³⁺ emission at 608 nm. This reciprocal spectral response enables precise and autofluorescence-free ratiometric TGL imaging of mitochondrial O₂^•− using the <i>I</i>₅₃₈/<i>I</i>₆₀₈ ratio as a quantitative readout. In parallel, the complexation with Gd³⁺ yields Mito-BOTTA-Gd³⁺, where the paramagnetic Gd³⁺ ion quenches the ¹⁹F MR signal. The cleavage of TFBS in the presence of O₂^•− releases the fluorinated TFBS moiety, which restores the ¹⁹F MR signal, enabling a complementary “turn-on” MR detection for O₂^•−. Both probes demonstrated excellent mitochondrial localization, low cytotoxicity, and robust responsiveness to O₂^•− in HepG2 cells as well as in murine models of alcohol- and CCl₄-induced acute liver injuries, which suggested the potential of the probes for dual-mode TGL and ¹⁹F MR bioimaging of O₂^•−, offering a promising approach for the diagnostics of oxidative stress-related diseases.</p>\u0000 </div>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 13","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145958242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precise Synergistic Photoregulation of Dual-Target Gene Expression by Engineering Caged Two-in-One DNA-RNA Nanoframework Based on Near-Infrared Light Uncaging Strategy.","authors":"Shanyu Cai, Yizhi Man, Jiaojiao Yu, Chunqing Zhou, Zhimin Weng, Yuanrong Liao, Mengting Zhang, Qing Li, Jiaan Liu, Xinjing Tang, Wei Chen, Changmai Chen","doi":"10.1002/adhm.202505572","DOIUrl":"https://doi.org/10.1002/adhm.202505572","url":null,"abstract":"<p><p>The synergistic regulation of gene expression at spatiotemporal resolution is of great importance for exploring specific gene functions and regulating biological processes. Here, we have designed and developed an engineering caged two-in-one DNA-RNA nanoframework woven with near-infrared responsive divalent siRNAs, which can be used for the synergistic photoregulation of dual-target tumor gene expression. In-situ generated reactive oxygen species using near-infrared light can release dual-target divalent siRNAs from caged DNA-RNA tetrahedron through the scission reaction induced by reactive oxygen species. The caged two-in-one DNA-RNA nanoframework was temporarily inhibited from RNAi-induced gene silencing activity without light irradiation. Near-infrared light irradiation effectively blocked the synergistic driving effects of two key cancer oncogenes, CENPF and FOXM1, through precise photoregulation of dual-target gene expression and tumorigenic PI3K and MAPK signaling pathways to achieve the cellular synergistic anti-tumor effects of combinatorial RNAi. The self-assembled caged two-in-one DNA-RNA nanoframework achieved the simultaneous photoregulation of dual-target RNAi-induced gene silencing in living tumor cells with spatiotemporal resolution. Furthermore, the NIR-responsive antitumor effect of the caged two-in-one DNA-RNA nanoframework was also achieved in vivo. This engineering caged two-in-one DNA-RNA nanoframework will provide a promising toolbox and strategy for exploring gene regulatory networks and divalent siRNA-based precise therapies.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e05572"},"PeriodicalIF":9.6,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147637415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Engineering of Quinolinium Cyanine Nanoagonist for Metastasis-Suppressed NIR-II Photothermal Immunotherapy","authors":"Yingzhe Wang,&nbsp;Anqi Shen,&nbsp;Mingwang Yang,&nbsp;Mengmeng Yuan,&nbsp;Zhonghua Liu,&nbsp;Danhong Zhou,&nbsp;Yongwei Huang,&nbsp;Xiaojing Li","doi":"10.1002/adhm.202504391","DOIUrl":"10.1002/adhm.202504391","url":null,"abstract":"<div>\u0000 \u0000 <p>Despite the therapeutic promise of photothermal immunotherapy in triple-negative breast cancer (TNBC), engineering second near-infrared (NIR-II) window-responsive organic immunophotothermal agents persists as a critical hurdle. We address this gap by designing a molecularly tailored NIR-II photothermal sensitizer (BOQCyCN), which concurrently enables tumor-localized hyperthermia and systemic immunomodulation for combinatorial tumor clearance. Rational structure manipulation through benzyl donor-cyano acceptor functionalization on a 4-methylquinoline core induces a redshifted absorption maximum (λ_max = 1022 nm), achieving deep-tissue penetration within the NIR-II biological therapeutic window. Co-assembly with DSPE-mPEG2000 generates stable BOQCyCN nanoparticles (NPs) exhibiting ultrahigh photothermal conversion (PCE, η = 62.9%) and irradiation resistance. At low irradiance (1064 nm, 0.6 W cm⁻²), NPs initiate synergistic therapeutic cascades: (1) Primary tumor ablation (95% volume reduction) with amplified T-cell infiltration (CD8⁺: 5.5-fold; CD4⁺: 2.3-fold); (2) Immunophenotype reprogramming via pro-inflammatory M1 macrophage skewing (M1/M2: 2.55 vs. 0.33); (3) Metastatic suppression (96% reduced distal tumor burden). This thermo-immunological nanoplatform establishes crosstalk between localized hyperthermia and antitumor immunity, advancing a translatable paradigm for TNBC management.</p>\u0000 </div>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 13","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145987453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smart Catheters for Diagnosis, Monitoring, and Therapy (Adv. Healthcare Mater. 13/2026)","authors":"Azra Yaprak Tarman,&nbsp;Samiha Ahmed,&nbsp;Majed Othman Althumayri,&nbsp;Megan Guy,&nbsp;Darlenne Chavez Lugo,&nbsp;Frances S. Ligler,&nbsp;George T. Ligler,&nbsp;Rahmi Oklu,&nbsp;Hiroshi Kawahira,&nbsp;Michael J. McShane,&nbsp;Jun Kameoka,&nbsp;Jonathan Bova,&nbsp;Hatice Ceylan Koydemir","doi":"10.1002/adhm.70866","DOIUrl":"10.1002/adhm.70866","url":null,"abstract":"<p><b>Therapeutic Systems</b></p><p>Catheters are evolving from simple access tools into integrated platforms for real-time sensing and targeted therapy. This cover depicts a smart catheter combining microstructured tip features, conformal sensors, flexible electronics, and responsive coatings for imaging, drug delivery, ablation, monitoring, and precise navigation. More details can be found in the Research Article by Hatice Ceylan Koydemir and co-workers (DOI: 10.1002/adhm.202503913).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 13","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.70866","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147683397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spherical Skin Model: Stratified Co-Culture of Fibroblasts and Keratinocytes on Spherical Beads Toward Compound Screening (Adv. Healthcare Mater. 13/2026)","authors":"Elisa Lenzi,&nbsp;Nadia Vertti-Quintero,&nbsp;Julien Husson,&nbsp;Anne-Laure Bulteau,&nbsp;Carine Nizard,&nbsp;Karl Pays,&nbsp;Sébastien Sart,&nbsp;Charles N. Baroud","doi":"10.1002/adhm.70869","DOIUrl":"10.1002/adhm.70869","url":null,"abstract":"<p><b>Skin Model</b></p><p>This cover art illustrates a proposed Spherical Skin Model (SSM), featuring a core-shell structure that mimics the human dermis-epidermis organization. The SSMs are used to screen active ingredients with potential antioxidant benefits for the cells within the model. Their high reproducibility and ease of handling enable efficient high-throughput screening. More details can be found in the Research Article by Nadia Vertti-Quintero, Charles N. Baroud, and co-workers (DOI: 10.1002/adhm.202503250).\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 13","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.70869","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147683416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smart Catheters for Diagnosis, Monitoring, and Therapy","authors":"Azra Yaprak Tarman,&nbsp;Samiha Ahmed,&nbsp;Majed Othman Althumayri,&nbsp;Megan Guy,&nbsp;Darlenne Chavez Lugo,&nbsp;Frances S. Ligler,&nbsp;George T. Ligler,&nbsp;Rahmi Oklu,&nbsp;Hiroshi Kawahira,&nbsp;Michael J. McShane,&nbsp;Jun Kameoka,&nbsp;Jonathan Bova,&nbsp;Hatice Ceylan Koydemir","doi":"10.1002/adhm.202503913","DOIUrl":"10.1002/adhm.202503913","url":null,"abstract":"<p>This review explores smart catheters as an emerging class of medical devices that combine embedded sensors, robotics, and communication systems with increasing functionality and complexity to enable real-time health monitoring, diagnostics, and treatment. Evolving from traditional catheters used as drains or entry ports, smart systems are now able to track blood pressure, temperature, biochemical signals, and mechanical forces within the body with a high degree of accuracy. Advances in materials, wireless communication, and robotic navigation have helped reduce common risks like infection and catheter blockage while also improving precision catheter placement for minimally invasive procedures. This review highlights recent developments across a variety of different types of smart catheters, ranging from sensing and imaging tools to therapeutic and multimodal systems. Additionally, it discusses the challenges that remain, including biocompatibility, long-term performance, and clinical translation. The incorporation of new capabilities is changing how catheters are used, and these new uses promise to enable more personalized and responsive healthcare.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 13","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12721224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145533978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}