Advanced Healthcare Materials最新文献_第10页

Cepharanthine Loaded TCPP-MOF Triggers Pyroptosis Through TSPO Inhibition for Hepatocellular Carcinoma Sonodynamic-Chemotherapy. 肝细胞癌声动力化疗中，头孢蒽醌负载TCPP-MOF通过抑制TSPO引发热凋亡。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-06-25 DOI: 10.1002/adhm.202500630

Hai-Tao Li, Jichu Zhao, Jing-Yu Lu, Xing-Chun Peng, Ning Han, Liu-Gen Li, Nan-Nan Chen, Yao-Hua Lu, Li-Jiong Wang, Fan Leng, Fei Zhu, Cunqing Kong, Jun Hu, Tong-Fei Li

{"title":"Cepharanthine Loaded TCPP-MOF Triggers Pyroptosis Through TSPO Inhibition for Hepatocellular Carcinoma Sonodynamic-Chemotherapy.","authors":"Hai-Tao Li, Jichu Zhao, Jing-Yu Lu, Xing-Chun Peng, Ning Han, Liu-Gen Li, Nan-Nan Chen, Yao-Hua Lu, Li-Jiong Wang, Fan Leng, Fei Zhu, Cunqing Kong, Jun Hu, Tong-Fei Li","doi":"10.1002/adhm.202500630","DOIUrl":"https://doi.org/10.1002/adhm.202500630","url":null,"abstract":"Pyroptosis is the critical approach for the induction of robust cancer cell death and activation of the immune microenvironment, which often results from mitochondrial damage. Herein, a combination strategy of sonodynamic-chemotherapy is designed to achieve an anti-heptocellular (HCC) effect, wherein the cepharanthine (Cep), a kind of functional phytomedicine, is loaded into the Tris(chlorisopropyl)Phosphate (TCPP) Metal-organic framework (MOF). The Cep@TCPP-MOF is successfully developed, as characterized by techniques such as transmission electron microscopy (TEM) and dynamic light scattering (DLC). The tumor-targeted ability of Cep@TCPP-MOF is validated by in vivo imaging. In-depth in vitro experiments presented Cep@TCPP-MOF can be taken up by Huh-7 and HepG2 cells, which collapse in response to the sonodynamic therapy (SDT). The released Cep can bind to an inactive translocator protein (TSPO), a kind of transporter on the membrane of mitochondria, while TCPP induces ROS generation under the SDT, thereby enhancing mitochondria damage. Further exploration shows that the Cep@TCPP-MOF treatment induces pronounced pyroptosis, which leads to HCC inhibition. To sum up, sonodynamic-chemotherapy nanoplatforms, composed by Cep-loaded TCPP-MOF are developed, which have sonodynamic responsiveness to release Cep and TCPP. TSPO inhibition-induced mitochondrial damage by Cep, coupled with ROS generated by TCPP-SDT, synergistically elicits pyroptosis and thereby fulfills the anti-HCC role.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2500630"},"PeriodicalIF":10.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Porous Microspheres Loading Small Molecule Targeting REV-ERBs Modulate Inflammatory Cytokines Fluctuations to Promote Periodontal Bone Regeneration. 装载靶向REV-ERBs的小分子多孔微球调节炎症细胞因子波动促进牙周骨再生。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-06-25 DOI: 10.1002/adhm.202500867

Nayun Li, Guangxia Feng, Yuqing Liu, Yuru He, Yuxiao Shi, Jiwei Sun, Qingming Tang, Yunsong Shi, Jinyu Wang, Yifan Wang, Lili Chen

{"title":"Porous Microspheres Loading Small Molecule Targeting REV-ERBs Modulate Inflammatory Cytokines Fluctuations to Promote Periodontal Bone Regeneration.","authors":"Nayun Li, Guangxia Feng, Yuqing Liu, Yuru He, Yuxiao Shi, Jiwei Sun, Qingming Tang, Yunsong Shi, Jinyu Wang, Yifan Wang, Lili Chen","doi":"10.1002/adhm.202500867","DOIUrl":"https://doi.org/10.1002/adhm.202500867","url":null,"abstract":"Alveolar bone loss, mainly due to periodontitis and local inflammation, poses a great challenge for current bone graft materials. To address this issue, we introduce PLGA-S@Gel-SeHA, a microsphere composed of Poly(lactic-co-glycolic acid) (PLGA), gelatin mineralized selenium-doped hydroxyapatite (Gel-SeHA) and STL1267 (S), which target circadian rhythm gene REV-ERBs (nuclear recerptor subfamily 1, group D, NR1D), to maintain inflammatory cytokine homeostasis for alveolar bone repair. Synthesized via iso-density emulsion and microfluidics, the PLGA-S@Gel-SeHA microspheres are of uniform size and porosity, greatly enhancing the cell adhesion and ingrowth. The combination of Gel-SeHA with PLGA provides abundant biomineralization sites and osteogenic activities. Incorporation of STL1267, currently the safest and most effective small molecule compound targeting REV-ERBs, enables sustained release that mitigates the severe fluctuations of inflammatory cytokines under LPS stimulation. Specifically, it reduces the levels of IL-6, TNF, and IL-1β by over 30% at critical circadian time points, thereby restoring their normal rhythmic expression. This promotes macrophage polarization toward anti-inflammatory M2 phenotypes favorable for osteogenesis. In rat alveolar bone defects, these microspheres demonstrate effective inflammation regulation and significant bone regeneration. By targeting circadian rhythm genes to redress the abnormal inflammatory cytokines fluctuations, this approach may provide a feasible anti-inflammatory strategy for bone repair.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2500867"},"PeriodicalIF":10.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeted Neuroimmune Modulation via FGF21-Loaded Dual-Layer Electrospun Nanofibrous Scaffold to Suppress Secondary Injury After Severe Traumatic Brain Injury. 负载fgf21的双层电纺丝纳米纤维支架靶向神经免疫调节抑制重型颅脑损伤后继发性损伤

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-06-25 DOI: 10.1002/adhm.202500905

Xiaoyan Bao, Mengjiao Xu, Yangyang Shentu, Wenting Huang, Ting Pan, Tao He, Yanru Du, Xinyi Xu, Yiyuan Lu, Rendi Wu, Hao Wang, Jiehui Zhao, Huiqin Xu, Qingyu Tao, Xiaokun Li, Li Lin

{"title":"Targeted Neuroimmune Modulation via FGF21-Loaded Dual-Layer Electrospun Nanofibrous Scaffold to Suppress Secondary Injury After Severe Traumatic Brain Injury.","authors":"Xiaoyan Bao, Mengjiao Xu, Yangyang Shentu, Wenting Huang, Ting Pan, Tao He, Yanru Du, Xinyi Xu, Yiyuan Lu, Rendi Wu, Hao Wang, Jiehui Zhao, Huiqin Xu, Qingyu Tao, Xiaokun Li, Li Lin","doi":"10.1002/adhm.202500905","DOIUrl":"https://doi.org/10.1002/adhm.202500905","url":null,"abstract":"Containment of secondary injury following severe traumatic brain injury (sTBI) is crucial for preserving neural tissue and function, especially when a dysregulated neuroimmune response exacerbates inflammation. However, effective therapeutic interventions targeting neuroimmune remodeling remain lacking. In this study, fibroblast growth factor 21 (FGF21) is identified as a promising immunomodulatory candidate, and a dual-layer electrospun scaffold is developed for efficient FGF21 delivery to the brain. FGF21 is stabilized within poly(lactic acid) (PLA), as confirmed by molecular docking, and incorporated into a PLA/triglycerol monostearate (PT) nanofiber inner layer for matrix metalloproteinase-9 (MMP-9)-responsive drug release. A crosslinked zein/gelatin (CZG) outer layer is added to support dura mater recovery. In a murine sTBI model, RNA sequencing revealed that FGF21 modulates neuroinflammation by suppressing type I interferon signaling and downstream chemotaxis, thereby shifting microglia from an aggressive pro-inflammatory to a restorative phenotype, with concurrent reductions in microglial proportion and amoeboid morphology. Magnetic Resonance Imaging (MRI)Magnetic Resonance Imaging imaging and behavioral assessments further confirmed the neuroprotective effects of FGF21@PT/CZG and demonstrated improvements in sensorimotor and neurological functions. These findings suggest that this nanofibrous scaffold offers a promising therapeutic strategy for targeted immunomodulation and functional recovery following sTBI.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2500905"},"PeriodicalIF":10.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acceleration of Calvarial Bone Regeneration by Stem Cell Recruitment with a Multifunctional Hydrogel. 用多功能水凝胶招募干细胞加速颅骨骨再生。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-06-25 DOI: 10.1002/adhm.202501452

Dandan Song, Yuanmao Fu, Qianrong Zhou, Minna Fu, Xingwen Wu, Yang Sun, Wei Bi, Jian Sun, Fei Yang, Hui Guo, Youcheng Yu

{"title":"Acceleration of Calvarial Bone Regeneration by Stem Cell Recruitment with a Multifunctional Hydrogel.","authors":"Dandan Song, Yuanmao Fu, Qianrong Zhou, Minna Fu, Xingwen Wu, Yang Sun, Wei Bi, Jian Sun, Fei Yang, Hui Guo, Youcheng Yu","doi":"10.1002/adhm.202501452","DOIUrl":"https://doi.org/10.1002/adhm.202501452","url":null,"abstract":"Hydrogels have garnered increasing attention for critical-size bone regeneration. However, the limited functionality and tedious preparation procedure of current hydrogel often fall short of meeting clinical requirements. In this study, a simple and effective strategy for preparing a multifunctional physically crosslinked hydrogel (CHMgel) for bone regeneration, which integrates a carboxymethyl cellulose (CMC) framework with Mg2+ and hydroxyapatite (HAP), is presented. Through the formation of strong intermolecular hydrogen bonds, the hydrogel exhibits a range of desirable properties, including injectability, high adhesion, satisfactory self-healing capacity, moderate mechanical strength, good biodegradability, and excellent biocompatibility. In vivo testing further demonstrates that CHMgel significantly promotes stem cell recruitment and the formation of new lamellar bone. Single-cell RNA sequencing (scRNA-seq) and in vitro assays show that CHMgel enhances in situ stem cell proliferation, bone marrow mesenchymal stem cells (BMSCs) migration, and osteogenic potential, thereby accelerating bone regeneration. Notably, Cmss1(hi) stem cells are markedly upregulated, influencing endochondral ossification through the elevated expression of key proteins, including Filip1l, Celf2, and Cmss1. The cellular characteristics and interactions observed in this study deepen the understanding of skeletal stem cell subsets in early biomaterial-aided bone regeneration, providing a foundation for material strategies aimed at controlling osteogenesis.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2501452"},"PeriodicalIF":10.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Colon-Targeted Natural Polysaccharide-Berberine Armored Hydrogel for the Treatment of Colitis. 结肠靶向天然多糖-小檗碱装甲水凝胶治疗结肠炎。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-06-25 DOI: 10.1002/adhm.202404908

Miao Guo, Bo Li, Hongyi Li, Yi Chen, Qin Yuan, Mingju Shui, Hefeng Zhou, Wei Hao, Shengpeng Wang

{"title":"Colon-Targeted Natural Polysaccharide-Berberine Armored Hydrogel for the Treatment of Colitis.","authors":"Miao Guo, Bo Li, Hongyi Li, Yi Chen, Qin Yuan, Mingju Shui, Hefeng Zhou, Wei Hao, Shengpeng Wang","doi":"10.1002/adhm.202404908","DOIUrl":"https://doi.org/10.1002/adhm.202404908","url":null,"abstract":"The maintenance of gut immune homeostasis and microbial balance is pivotal in the pathogenesis and progression of ulcerative colitis (UC). Despite advances in therapy, effective UC management remains challenging due to the limited efficacy and significant side effects of conventional treatments. Inspired by the synergistic mechanisms of bioactive compounds in traditional Chinese medicine, a colon-targeted hydrogel integrating rhubarb-derived polysaccharides and berberine-loaded dendrimers is engineered. This hydrogel self-assembles via intermolecular hydrogen bonding and electrostatic interactions, enabling localized accumulation in colonic tissues to suppress aberrant immune activation and remodel the dysbiotic microbiome. Mechanistic studies reveal that the hydrogel potently promotes the polarization of anti-inflammatory M2 macrophages while suppressing pro-inflammatory cytokine secretion, resulting in significant amelioration of colitis symptoms in murine models. Importantly, the therapeutic intervention not only restored gut microbiota composition but also corrected metabolic disturbances, collectively contributing to the re-establishment of intestinal homeostasis. The findings underscore the potential of this polysaccharide-based hydrogel as an effective oral therapeutic strategy for UC while demonstrating the translational value of combining natural bioactive constituents for targeted drug delivery.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2404908"},"PeriodicalIF":10.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combination of Polydopamine and Plasma Oxidation Increases Tissue Integration of Polyurethane-Silicone Copolymers for Cardiovascular Implants. 聚多巴胺和血浆氧化的结合增加了聚氨酯-有机硅共聚物用于心血管植入物的组织整合。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-06-25 DOI: 10.1002/adhm.202500577

Sophie Armstrong, Jennifer Dyson, Lingxiao Zeng, Saeedreza Zeibi Shirejini, John Forsythe, Shaun D Gregory

{"title":"Combination of Polydopamine and Plasma Oxidation Increases Tissue Integration of Polyurethane-Silicone Copolymers for Cardiovascular Implants.","authors":"Sophie Armstrong, Jennifer Dyson, Lingxiao Zeng, Saeedreza Zeibi Shirejini, John Forsythe, Shaun D Gregory","doi":"10.1002/adhm.202500577","DOIUrl":"https://doi.org/10.1002/adhm.202500577","url":null,"abstract":"Polyurethane (PU)-silicone co-polymers are increasingly favored in medical applications due to their excellent biostability and durability; however, their intrinsic hydrophobicity limits tissue integration. Polydopamine (PDA) deposition is a widely accepted method for increasing biomaterial surface hydrophilicity, though concentrations and methods vary across published literature. This study investigates the synergistic effects of PDA deposition and plasma oxidation on FDA-approved Elast-Eon E2A (E2A) to enhance cell attachment and wound healing. E2A substrates are treated with a range of plasma oxidation periods and PDA concentrations (0-5 min, 0-0.5 w v-1% respectively). The combination of 0.05 w v-1% PDA and 1-minute oxygen plasma results in the most significant reduction in water contact angle (92to 19°), increase in fibroblast adhesion (33.0-53.2 cells mm-2) and cell diameter, with an overall increase in intra- and extracellular collagen I and fibronectin. X-ray photoelectron spectroscopy (XPS) reveals significant surface chemical changes, while surface roughness remains unchanged. Whole blood adhesion tests show no change in platelet adhesion or volume. These parameters may offer an improved approach for modifying PU-copolymers to enhance cell interactions for use in current and future medical implants, including a suite of cardiovascular technologies that require both material ductility and rapid tissue integration.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2500577"},"PeriodicalIF":10.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Admixing of mRNA with Pre-Formed Lipid Nanoparticles Containing a Slightly-Cationic Ionizable Lipid Allows for Efficient mRNA Transfection In Vitro and In Vivo. 混合mRNA与预先形成的脂质纳米颗粒含有微阳离子可电离脂质允许有效的mRNA转染在体外和体内。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-06-25 DOI: 10.1002/adhm.202501788

Haixiu Wang, Heleen Lauwers, Mark Gontsarik, Yong Chen, Niek N Sanders, Miffy Hok Yan Cheng, Bruno G De Geest, Zifu Zhong

{"title":"Admixing of mRNA with Pre-Formed Lipid Nanoparticles Containing a Slightly-Cationic Ionizable Lipid Allows for Efficient mRNA Transfection In Vitro and In Vivo.","authors":"Haixiu Wang, Heleen Lauwers, Mark Gontsarik, Yong Chen, Niek N Sanders, Miffy Hok Yan Cheng, Bruno G De Geest, Zifu Zhong","doi":"10.1002/adhm.202501788","DOIUrl":"https://doi.org/10.1002/adhm.202501788","url":null,"abstract":"Therapeutic mRNA has emerged as a powerful tool in medicine. However, due to its fragility and large size, mRNA requires a carrier for delivery into the cellular cytosol. Lipid nanoparticles (LNPs), produced by rapidly mixing an aqueous mRNA solution with an ethanolic solution containing lipids, are currently considered the most advanced carriers for this purpose. Electrostatic interactions between mRNA and the ionizable cationic lipid, combined with hydrophobic interactions among all lipids, lead to self-assembly into LNPs that accommodate the mRNA in their core. In this study, whether mixing mRNA with pre-formed, empty LNPs (eLNPs) in an aqueous medium can be a viable alternative for mRNA expression is investigated. It is confirmed that mRNA can associate with eLNPs via electrostatic interactions, with the effectiveness of this association depending on the surface charge of the eLNPs and the ionizable lipid component. Furthermore, post-loading mRNA into eLNPs demonstrates mRNA expression levels comparable to conventional LNP(mRNA) formulations, both in vitro and in mice. This method of leveraging eLNPs offers a practical alternative to conventional LNP(mRNA) formulation for the rapid screening of multiple mRNAs. It can also enable straightforward use of LNPs for mRNA transfection by users who do not have the capacity to perform LNP formulation.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2501788"},"PeriodicalIF":10.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dissolving Microneedle Patch for Peripheral Delivery of Pregabalin in Neuropathic Pain Management. 溶解微针贴片外周给药普瑞巴林治疗神经性疼痛。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-06-24 DOI: 10.1002/adhm.202500316

Aining Zhang, Wenxin Wu, Siyuan Wang, Xin Liu, Xue Jiang, Yangwenzheng Xiao, Wei Li, Mian Peng

{"title":"Dissolving Microneedle Patch for Peripheral Delivery of Pregabalin in Neuropathic Pain Management.","authors":"Aining Zhang, Wenxin Wu, Siyuan Wang, Xin Liu, Xue Jiang, Yangwenzheng Xiao, Wei Li, Mian Peng","doi":"10.1002/adhm.202500316","DOIUrl":"https://doi.org/10.1002/adhm.202500316","url":null,"abstract":"Neuropathic pain is a complex and debilitating condition that presents substantial challenges for effective treatment, as it often persists despite conventional therapies and can significantly impair the quality of life of affected individuals. Currently, pregabalin is the first-line treatment for neuropathic pain. However, its oral dosage form is often associated with adverse reactions such as dizziness and drowsiness, and its administration duration is limited, requiring frequent dosing. To address these issues, this study developed a hyaluronic acid (HA)-based dissolving microneedle (MN) patch incorporating poly (lactic-co-glycolic acid) (PLGA) microspheres (MS) loaded with pregabalin (PG) for peripheral administration. The MN array consists of 10 × 10 needles, covering an area of ≈0.5 cm2, with each needle having a height of 850 µm. The MN patch demonstrated significant analgesic effects and sustained drug release at the application site for up to 48 h, effectively alleviating pain while minimizing dizziness and drowsiness, which are the most common side effects after systemic administration. This innovative MN platform presents a promising strategy for neuropathic pain management and provides a novel therapeutic paradigm for the peripheral application of centrally acting analgesics.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2500316"},"PeriodicalIF":10.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Energy Metabolism Nanoblocker for Cutting Tumor Cell Respiration and Inhibiting Mitochondrial Hijacking from Cytotoxic T Lymphocyte (Adv. Healthcare Mater. 16/2025) 一种能量代谢纳米阻断剂用于切断肿瘤细胞呼吸和抑制细胞毒性T淋巴细胞的线粒体劫持（Adv. Healthcare Mater. 16/2025）

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-06-23 DOI: 10.1002/adhm.202570098

Xiaojing Leng, Yang Yang, Tao Jiang, Jun Zheng, Liang Zhang, Ju Huang, Han Xu, Mingxiao Fang, Xingsheng Li, Zhigang Wang, Min Ge, Han Lin

引用次数: 0

Living Cell Materials for Advanced Biomedical Applications in Disease Diagnosis, Treatment, and Prevention. 活细胞材料在疾病诊断、治疗和预防方面的先进生物医学应用。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-06-23 DOI: 10.1002/adhm.202502358

Fanhui Kong, Jiani Jiang, Ekaterina Chernova, Stefan Wuttke, Wei Zhu, Qi Lei

{"title":"Living Cell Materials for Advanced Biomedical Applications in Disease Diagnosis, Treatment, and Prevention.","authors":"Fanhui Kong, Jiani Jiang, Ekaterina Chernova, Stefan Wuttke, Wei Zhu, Qi Lei","doi":"10.1002/adhm.202502358","DOIUrl":"10.1002/adhm.202502358","url":null,"abstract":"Tailored and personalized therapies have gained significant attention for their great potential to minimize treatment-related side effects, mitigate immunological rejection, and improve disease prognosis. In this context, living cell materials (LCMs)-comprising living cells integrated with synthetic or non-biological components-synergistically combine the intrinsic properties of living cells with the superior functionalities of synthetic materials, enabling precise disease diagnosis and customized therapies. In this review, the characteristics and advantages of various living mammalian and bacterial cells utilized in the fabrication of living materials are summarized. Different methodologies (encapsulation, surface coating, intracellular loading, and cell backpack) for constructing LCMs, highlighting the benefits and limitations of each approach, along with their diverse applications in diagnosis and treatment are also discussed. Finally, the potential strategies are addressed to enhance the safety of living cell therapies, exploit novel functionalities, and facilitate the translation of fundamental research into clinical practice.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2502358"},"PeriodicalIF":10.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0