Advanced Healthcare Materials最新文献

{"title":"γ-Radionuclide Technetium-99M Activated Long-Lasting Chemodynamic Therapy and Immunogenic Brachytherapy for Enhanced Antitumor Immunity.","authors":"Naihan Huang, Wen Li, Lin Liu, Weibing Miao","doi":"10.1002/adhm.71795","DOIUrl":"https://doi.org/10.1002/adhm.71795","url":null,"abstract":"<p><p>Chemodynamic therapy (CDT) and brachytherapy face critical challenges, particularly the limited efficiency of Fenton reaction and the insufficient antitumor immunogenicity of brachytherapy. In this study, we employ the metal-organic framework nanocomposite Hf-TCPP@Fe-^99mTc (where TCPP = tetrakis(4-carboxyphenyl) porphyrin and ^99mTc = technetium-99m) for synergistic long-lasting CDT and immunogenic brachytherapy. Benefiting from the robust interaction between ^99mTc-emitted γ-rays and the high-Z element Hf, the secondary electrons generated during brachytherapy not only damage tumor cells but also establish an electron-rich microenvironment that drives the continuous reduction of Fe³⁺ to Fe²⁺, thereby sustaining a highly efficient Fenton reaction. With the generation of hydroxyl radical persisting for over 12 h, this synergistic effect reduced cell viability by an additional 28.6% beyond projections, thereby inducing effective immunogenic cell death, activating a systemic antitumor immune response, and inhibiting both primary and metastatic triple-negative breast cancer. Through rational design, this work demonstrates that clinically prevalent nontherapeutic γ-radionuclide can activate long-lasting CDT and immunogenic brachytherapy to enhance antitumor immunogenicity.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71795"},"PeriodicalIF":11.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Antimicrobial, Cell-Adhesive, and Growth Factor-Producing Living Material Engineered From Bacillus subtilis Biofilms for Wound Healing.","authors":"Mélanie Côté-Cyr, Marie-Jeanne Archambault, Caroline Dupuis, Steve Bourgault","doi":"10.1002/adhm.71823","DOIUrl":"https://doi.org/10.1002/adhm.71823","url":null,"abstract":"<p><p>Chronic wounds represent a burden for healthcare systems and critically impair quality of life of patients. Engineered living materials (ELMs) show great potential as scaffolds and delivery systems in tissue regeneration. As a generally regarded safe biofilm-producing organism, Bacillus subtilis (B. subtilis) presents interesting properties to develop functional ELMs in biomedicine. In this study, we engineer B. subtilis to design a protein-based living matrix eluting bioactive sequences for wound healing. Accordingly, we create a biofilm-deficient B. subtilis strain that expressed the biofilm scaffold protein, TasA in fusion with a cell-adhesive motif (TasA-PRb), which results in biofilms with cell-adhesive properties for fibroblasts and keratinocytes. Besides, B. subtilis is known to elicit antimicrobial properties against strains of E. coli and S. epidermidis, which are not impeded by biofilm engineering. We also incorporate secretion of fibroblast growth factor 2 (FGF2), known to promote wound healing, in the biofilm-deficient strain. Co-culture of FGF2-expressing and TasA-PRb producing strains resulted in biofilms secreting bioactive FGF2. Chronic wound healing assays in diabetic mice reveal accelerated wound closure in mice treated with the TasA-PRb/FGF2 biofilms, with absence of observable adverse effects. This underlines the potential of the B. subtilis biofilm for the design of functional ELMs in biomedicine.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71823"},"PeriodicalIF":11.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “3D-Printed Sugar-Based Stents Facilitating Vascular Anastomosis”","authors":"","doi":"10.1002/adhm.71496","DOIUrl":"10.1002/adhm.71496","url":null,"abstract":"<p>A. Farzin, A. K. Miri, F. Sharifi, et al., “3D-Printed Sugar-Based Stents Facilitating Vascular Anastomosis,” Advanced Healthcare Materials 7, no. 24 (2018): 1800702, https://doi.org/10.1002/adhm.201800702.</p><p>Concerns were raised by a third party regarding duplicated and inverted image sections within the subpanels of Figures S1a and S1b. The authors acknowledged these image compilation errors and the inconsistencies in the image processing and, upon further review, identified additional sub-panel duplications in Figure 2c. They further clarified that the same control images were intentionally reused across Figures 2c and S1a,b, as they were part of the same experiment conducted using a single blood sample. However, due to the time elapsed since publication, the comprehensive raw data were no longer available.</p><p>In light of this, the authors repeated the experiments. The new data confirm that the corresponding experimental results and the overall conclusions of the paper remain valid and unaffected.</p><p>The corrected versions of Figures S1 and 2b,c are provided below. The authors would like to further note that, since the clotting test was conducted at 1 min intervals, there was no difference in the clotting time between most of the replicates. Therefore, error bars are not shown for samples where no difference was observed in the clotting time between the replicates.</p><p></p><p><b>FIGURE S1</b> Effect of (a) sucrose and (b) glucose on clotting time of activated blood. Glucose enhanced the thrombogenicity while sucrose showed a reverse effect (<i>n</i> = 3). (**<i>p</i> &lt; 0.01, ***<i>p</i> &lt; 0.001). The experiments were performed within 48-well plates, where the inside diameter of the wells is ∼10.6 mm.</p><p></p><p><b>FIGURE 2</b> Evaluation of mechanical properties, adhesion strength, blood clotting time, and rheological properties of sugar-based composition. (b,c) The clotting time assay of the sugar-based composition (11% (w/w) glucose, 69% (w/w) sucrose, 17% (w/w) dextran, and 3% (w/w) sodium citrate) shows that the optimized composition had low thrombogenicity (<i>n</i> = 3). The experiments were performed within 48-well plates, where the inside diameter of the wells is ∼10.6 mm.</p><p>We apologize for these errors.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 37","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.71496","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148663103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Cell-Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery","authors":"Clara Baldari,&nbsp;Claudia Leone,&nbsp;Gabriella Leccese,&nbsp;Claudia De Stradis,&nbsp;Alessandra Invidia,&nbsp;Concetta Quintarelli,&nbsp;Biagio De Angelis,&nbsp;Franco Locatelli,&nbsp;Giuseppe Gigli,&nbsp;Gabriele Maiorano,&nbsp;Ilaria Elena Palamà","doi":"10.1002/adhm.71640","DOIUrl":"10.1002/adhm.71640","url":null,"abstract":"<p>Nonviral gene therapy reached unprecedented clinical prominence, with the approval of lipid nanoparticles (LNPs). Yet, their success remains largely confined to a narrow range of applications and tissues, which reflects the inherent functional constraints based on formulation optimization to overcome intrinsically complex physiological barriers. In contrast, biological membranes evolved to integrate immune evasion, targeting, intracellular trafficking, and membrane fusion within a single functional interface. In this review, we provide a mechanistic comparison between membrane-derived vesicles (MDVs) and hybrid biomimetic systems. We critically examine MDVs from different biological sources, highlighting their unique advantages for gene delivery applications. We also focus on hybrid systems, which merge the biological functionality of naturally derived membranes with the design control of synthetic nanovectors to address key limitations such as inefficient cytosolic release, poor targeting specificity, and transfection of hard-to-engineer cells. This review provides a biologically informed roadmap for designing efficient gene delivery vectors, proposing membrane-integrated nanovesicles (NVs) as “living interfaces” for non-viral gene therapy.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 37","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.71640","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148811517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Bilayer Vascular Graft With Functionally Separated Structural Support and Bioactive Remodeling for Stable Small-Diameter Artery Repair","authors":"Linlin Guo,&nbsp;Qi Huang,&nbsp;Chao Xu,&nbsp;Xianzhen Dong,&nbsp;Yuyi Tian,&nbsp;Yawen Shi,&nbsp;Ye Xie,&nbsp;Chunlin Wen,&nbsp;Weici Wang,&nbsp;Yiqing Li,&nbsp;Hongjun Yang","doi":"10.1002/adhm.71660","DOIUrl":"10.1002/adhm.71660","url":null,"abstract":"<div>\u0000 \u0000 <p>Cardiovascular diseases remain a leading cause of mortality worldwide, and the lack of effective small-diameter vascular grafts (SDVGs, &lt; 6 mm) continues to limit clinical treatment options. A major challenge in the development of tissue-engineered vascular grafts (TEVGs) is the mismatch between material degradation and tissue regeneration rates, which is driven by individual variability and leads to failure in mechanical support transition, subsequent graft failure, and impeded clinical translation. Here, we report a functionally separated bilayer SDVG that decouples long-term structural support from early bioactive remodeling. The graft consists of a slowly degradable knitted polylactic acid (PLA) framework that preserves mechanical integrity, and a rapidly remodelable chitosan/gelatin (CS/GE) porous phase that promotes cell infiltration and tissue regeneration. By tuning the CS/GE composition, we identified a balanced remodeling window, in which the 1% CS/GE-PLA graft achieved favorable permeability, cytocompatibility, hemocompatibility, and mechanical performance. In a rabbit carotid interposition model, this optimized graft maintained 100% patency for 3 months and progressively remodeled into a native vessel-like trilaminar structure with endothelial coverage, smooth muscle organization, and extracellular matrix maturation. This bilayer design provides a strategy to coordinate scaffold degradation with tissue regeneration, enabling stable mechanical support and functional vascular remodeling in small-diameter grafts.</p>\u0000 </div>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 37","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148899745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NIR-II-Responsive Carbon Dot/Bi₂S₃ Enables Mild Hyperthermia-Amplified Sonocatalytic Therapy Through Heterojunctions Engineering.","authors":"Nan Wang, Guijun Zou, Nina Zhang, Can Yang, Zhihao Zhao, Jinyan Hu, Yan Zhao, Bijiang Geng, Saihua Yang, Lian Li","doi":"10.1002/adhm.71768","DOIUrl":"https://doi.org/10.1002/adhm.71768","url":null,"abstract":"<p><p>Sonodynamic therapy (SDT) demonstrates significant promise for noninvasive therapy of deep solid tumors such as cervical cancer, but its therapeutic efficacy is greatly restricted by low-efficiency sonosensitizers and the immunosuppressive tumor microenvironment (TME). Herein, we report the development of a novel Type-II carbon dot (CD)/Bi₂S₃ heterojunction for the mild NIR-II photothermal therapy (mPTT) amplified SDT/nanocatalytic therapy (NCT). The formation of heterojunctions drives the spatial separation of electron-hole pairs under ultrasound excitation, amplifying the generation of reactive oxygen species (ROS) while simultaneously utilizing highly oxidized holes to consume overexpressed GSH. In addition, under 1064 nm laser irradiation, the mild NIR-II photothermal effect generated by CD/Bi₂S₃ heterojunctions acts as a powerful thermodynamic accelerator, which not only enhances the intrinsic peroxidase (POD) and catalase (CAT) activities, but also relieves hypoxic TME. Based on the cascade amplification of ROS generation and reversal of immunosuppressive TME, CD/Bi₂S₃ heterojunctions not only achieve high-efficiency tumor eradication but also facilitate the infiltration of T cells in combination with PD-L1 inhibitors, successfully triggering a strong systemic antitumor immune response and inducing persistent immune memory. This work presents an innovative strategy for designing efficient heterojunction nanoplatforms that integrate mild NIR-II PTT, SDT, NCT, and TME regulation functions.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71768"},"PeriodicalIF":11.0,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly Deformable Organic Heterojunctions Empower Piezoelectric-Conductive Hydrogels for Functional Volumetric Muscle Regeneration.","authors":"Tianyu Gao, Guiyuan Zhang, Shuying Ren, Pan Wang, Long He, Jialai Zhang, Xiaohong Li","doi":"10.1002/adhm.71818","DOIUrl":"https://doi.org/10.1002/adhm.71818","url":null,"abstract":"<p><p>Volumetric muscle loss (VML) results in irreversible muscle impairment, necessitating tissue-matched electrostimulation scaffolds for clinical repair. Here, we report a biointegrated hydrogel that leverages a piezoelectric-conductive organic heterojunction to deliver self-powered electrical cues directly to the injury site. The heterojunction comprises a piezoelectric metal-organic framework (MOF) coated with conductive polypyrrole (PPy), forming a stable p-n organic heterojunction with an intrinsic built-in electric field. Unlike inorganic piezoelectrics, the organic MOF-PPy features an ultralow elastic modulus, porous architecture, and exceptional deformability, delivering robust piezoelectric output under mild muscular contraction. These MOF-PPy is then covalently integrated into a silk fibroin network via in situ photopolymerization to produce the MOF-PPy@Sil hydrogel, where covalent conjugation ensures efficient stress transfer, maximizing piezoelectric signal generation. The piezoelectric and conductive cues significantly promote cell viability and migration, upregulate myogenic markers, and enhance maturation of organized muscle fibers. In a rat tibialis anterior VML model, MOF-PPy@Sil drives myofiber formation, structural reconstruction, and near-complete restoration of hindlimb motor function. Mechanistically, the endogenous electroactive niche upregulates myogenic and metabolic pathways, while mitigating inflammatory responses that impede muscle regeneration. This work presents a piezoelectric-conductive hydrogel paradigm that harnesses the deformability of organic heterojunctions to generate a mechano-electrical microenvironment for regenerative medicine.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71818"},"PeriodicalIF":11.0,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrospun Core-Shell Bioadhesive Nanofiber Sheets Enable Durable Pulmonary Air Leak Sealing Under Wet and Dynamic Conditions.","authors":"Tomohito Okubo, Kouji Hara, Naoyuki Hatayama, Kota Takahashi, Eriko Yamazoe, Takaaki Ito, Takao Takeuchi, Yoko Koide, Mayumi Yamada, Munekazu Naito, Kohei Tahara","doi":"10.1002/adhm.71789","DOIUrl":"https://doi.org/10.1002/adhm.71789","url":null,"abstract":"<p><p>Pulmonary air leak is the most common complication following lung surgery. Most materials used for pulmonary fistula closure rely on fibrin network-mediated adhesion. However, on the moist and dynamically deforming lung surface, these materials often fail to provide sufficient adhesion, and postoperative air leaks remain a major clinical concern. Since these materials are biologically derived, concerns regarding biosafety risks and high production costs persist. To address these limitations, this study develops a novel closure material that integrates biocompatibility, pressure resistance, tissue adhesion, and seal retention under wet conditions. The closure material is fabricated as a nanofiber sheet via electrospinning. Comparative evaluation of different structural designs demonstrates that incorporating a core-shell nanofiber structure achieves a favorable balance of pressure resistance, tissue adhesion, and seal retention under wet conditions. Acute leak closure was evaluated in five animals, and long-term safety was assessed in three animals followed for 1 month. The mean air leak volume decreased from 46.2 to 1.8 mL/min, with post-treatment air leak volumes below the clinically accepted threshold (≤ 10 mL/min) in all five animals. No treatment-related complications were observed during the follow-up period. Thus, electrospun nanofiber sheets represent a promising and biosafe approach for pulmonary air leak closure.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71789"},"PeriodicalIF":11.0,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound/pH Dual-Responsive Cu-Zn-Based Microneedles for Piezo-Sonodynamic and Multimechanism Synergistic Induction of Cuproptosis and Ferroptosis.","authors":"Xueyan Zhang, Siqi Lin, Chunyu Yang, Mengshu Xu, Zhuoran Yang, Yuexin Li, Wei Guo","doi":"10.1002/adhm.71819","DOIUrl":"https://doi.org/10.1002/adhm.71819","url":null,"abstract":"<p><p>Sonodynamic therapy is hindered by the insufficient catalytic activity of nanomaterials, the robust antioxidant capacity of the tumor microenvironment, and the limited targeting efficiency of conventional drug delivery systems. In this study, CuSn(OH)₆ nanorods were synthesized via coprecipitation. These were then transformed into microspheres through zinc doping and calcination at 500°C under argon, yielding ZnSnO₃/Cu_0.97Zn_0.03 (CZ) nanocomposites. They exhibit excellent piezoelectric catalysis, sonodynamic activity, peroxidase-like activity, and glutathione degradation capacity. These enable the generation of substantial reactive oxygen species under ultrasound (US), which disrupts the redox balance in tumors. Subsequently, FCZ composite drug-loaded microneedles (FCZ-MN) loaded with CZ and 5-fluorouracil (5-Fu) were fabricated. Matrix optimization endowed FCZ-MN with superior mechanical strength and skin biocompatibility, enabling targeted transdermal delivery with pH-responsive and US-controllable drug release. In vitro and in vivo studies have demonstrated that FCZ‑MN combined with US effectively induces ferroptosis, cuproptosis, and apoptosis through multiple pathways, leading to significant tumor suppression without apparent systemic toxicity. This integrated strategy offers a promising alternative to conventional treatment modalities, providing an efficient and well-tolerated platform for localized transdermal tumor therapy.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71819"},"PeriodicalIF":11.0,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhaled Fluorinated Polymer Triggers Pyroptosis for Lung Cancer Immunotherapy.","authors":"Biyu Zhou, Nana Feng, Jian Xiao, Qingqing Huang, Qiushi Li, Yating Bai, Yang Liu","doi":"10.1002/adhm.71814","DOIUrl":"https://doi.org/10.1002/adhm.71814","url":null,"abstract":"<p><p>Lung cancer imposes the highest cancer-related mortality burden worldwide, while its responsiveness to immunotherapy is often constrained by the immunosuppressive pulmonary tumor microenvironment (TME) and tumor adaptations that buffer oxidative stress. Pyroptosis, a highly immunogenic form of programmed cell death that can be activated through mechanisms not strictly dependent on exogenous reactive oxygen species (ROS), offers a promising alternative for immune activation but remains challenging to induce effectively in vivo. Here, we report an inhalable fluorinated polymer nanoplatform (PFAP) that triggers mitochondrial dysfunction to initiate pyroptosis and thereby elicits potent antitumor immunity in the lung. PFAP integrates perfluoroalkyl segments with cationic domains to enhance interactions with mitochondrial membranes, while a detachable polyethylene glycol shell preserves nanoparticle stability during aerosolization and facilitates penetration of pulmonary barriers. Upon exposure to the acidic TME, PFAP restores membrane-disruptive activity, leading to mitochondrial depolarization, Cyto C release, caspase-3 activation, GSDME cleavage, and pyroptosis induction. In orthotopic and metastatic lung cancer models, inhaled PFAP achieves efficient lung delivery, elicits robust antitumor immunity, and suppresses tumor progression without detectable systemic toxicity. This work provides a nanomaterial-based approach for inducing pyroptosis in lung cancer and highlights the potential of inhalable polymer systems for localized cancer immunotherapy.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71814"},"PeriodicalIF":11.0,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}