Advanced Healthcare Materials最新文献_第9页

Double-Layer Multifunctional Sponge Constructed by Gel-Spray System and the Application in Rapid Hemostasis of Non-Compressible Hemorrhage. 凝胶喷射系统构建双层多功能海绵及其在非压缩性出血快速止血中的应用。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-15 DOI: 10.1002/adhm.202502910

Yuyan Zhang, Xiudan Wang, Jisen Li, Zhiguang Sun, Xinran Yang, Xiaoqin Guo, Haojun Fan, Jie Shi, Shike Hou, Qi Lv

{"title":"Double-Layer Multifunctional Sponge Constructed by Gel-Spray System and the Application in Rapid Hemostasis of Non-Compressible Hemorrhage.","authors":"Yuyan Zhang, Xiudan Wang, Jisen Li, Zhiguang Sun, Xinran Yang, Xiaoqin Guo, Haojun Fan, Jie Shi, Shike Hou, Qi Lv","doi":"10.1002/adhm.202502910","DOIUrl":"https://doi.org/10.1002/adhm.202502910","url":null,"abstract":"Non-compressible hemorrhage is a prevalent and life-threatening traumatic injury. Although significant progress is made in the development of hemostatic materials, there are still some major challenges, including poor hemostatic efficacy, potential tissue damage, and the risk of postoperative infection. In this study, a gel-spray system double-layer hemostatic sponge (GSD) is developed. GSD is formed by primary cross-linking of dopamine and secondary cross-linking of glutaraldehyde to produce an inner layer, and by surface spraying of active ingredients to produce an outer layer. To simulate non-compressible hemorrhage, we comprehensively evaluated the material using five different rat hemorrhage models. GSD exhibited excellent hemostatic effects in the above experiments. Specifically, in the femoral artery transection model, it significantly reduced bleeding time from 207.6 to 118.0 s and blood loss from 1417.4 to 789.8 mg. In the liver injury model, GSD reduced bleeding time by over 60% and blood loss by more than 50%. Additionally, GSD demonstrated powerful wound healing properties, with the experimental group showing a wound healing rate of over 80% by 7th day, and significantly promoting the formation of new blood vessels. GSD also has multifunctions such as antibacterial, anti-adhesion, and biodegradability.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e02910"},"PeriodicalIF":9.6,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145068713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cortical Response to Acute Implantation of the Utah Optrode Array in Macaque Cortex. 猕猴皮质对犹他光电极阵列急性植入的反应。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-15 DOI: 10.1002/adhm.202500575

Adrián Villamarin-Ortiz, Christopher F Reiche, Frederick Federer, Andrew M Clark, John D Rolston, Cristina Soto-Sánchez, Eduardo Fernandez, Steve Blair, Alessandra Angelucci

{"title":"Cortical Response to Acute Implantation of the Utah Optrode Array in Macaque Cortex.","authors":"Adrián Villamarin-Ortiz, Christopher F Reiche, Frederick Federer, Andrew M Clark, John D Rolston, Cristina Soto-Sánchez, Eduardo Fernandez, Steve Blair, Alessandra Angelucci","doi":"10.1002/adhm.202500575","DOIUrl":"10.1002/adhm.202500575","url":null,"abstract":"Optogenetics has transformed neural circuit studies, but its application to large-brained species like non-human primates (NHPs) remains limited. A major challenge in NHP optogenetics is delivering light to large volumes of deep neural tissue with high spatiotemporal precision, without affecting superficial tissue. To overcome these limitations, we recently developed and tested in vivo in NHP cortex, the Utah Optrode Array (UOA). This is a 10 × 10 array of penetrating glass shanks, tiling a 4 × 4 mm2 area, bonded to interleaved needle-aligned and interstitial µLED arrays, enabling independent photostimulation of deep and superficial tissue. Here, the acute biological response to UOA implantation in NHP cortex is investigated, to optimize device design for reduced insertion trauma and chronic response. To this goal, UOA shank diameter, geometry, and insertion pressure are varied, and their effects on astrocytes, microglia, and neuronal viability are assessed, following acute implantation. It is found that UOAs with smaller shank diameter, smooth surface texture, and round tips cause the least damage. Higher insertion pressures have limited effects on inflammation, but cause greater tissue compression. The results highlight the importance of balancing shank diameter, geometry, and insertion pressure in UOA design for preserving tissue integrity and improving long-term UOA performance and biocompatibility.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e00575"},"PeriodicalIF":9.6,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional Nanocarrier Drug Delivery Systems: From Diverse Design to Precise Biomedical Applications. 多功能纳米载体药物输送系统：从不同的设计到精确的生物医学应用。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-15 DOI: 10.1002/adhm.202502178

Yan-Fei Zhu, Meng-Qi He, Cai-Shi Lin, Wei-Heng Ma, Yongjian Ai, Jing Wang, Qionglin Liang

{"title":"Multifunctional Nanocarrier Drug Delivery Systems: From Diverse Design to Precise Biomedical Applications.","authors":"Yan-Fei Zhu, Meng-Qi He, Cai-Shi Lin, Wei-Heng Ma, Yongjian Ai, Jing Wang, Qionglin Liang","doi":"10.1002/adhm.202502178","DOIUrl":"https://doi.org/10.1002/adhm.202502178","url":null,"abstract":"Due to the high complexity of the disease mechanisms, rendering conventional single-target symptomatic therapies are increasingly inadequate to meet evolving clinical demands. Multifunctional nanocarrier drug delivery systems (MNDDS) with precision targeting and tunable functionalities have emerged as a revolutionary strategy to address current therapeutic limitations. MNDDS enables spatiotemporally controlled drug delivery and customizable therapeutic outcomes, thereby serving as a cornerstone for advancing precision medicine. To systematically survey the latest advancements in MNDDS and facilitate cross-disciplinary innovation, this review begins by classifying carrier platforms into biological and non-biological categories based on their constituent materials. Then, the integration of diverse therapeutic payloads, encompassing chemical agents, protein/peptide therapeutics, nucleic acid-based drugs, and other bioactive compounds are summarized. Following, engineering strategies are elaborated for achieving active targeting and passive targeting through systematic structural and surface modifications. Furthermore, the applications of MNDDS for disease treatment are highlighted. Finally, emerging strategies integrating intelligent bioinspired carrier design, dynamic smart materials, and personalized microenvironment engineering that hold transformative potential to bridge the gap from lesion-specific targeting to real-time theranostics are foregrounded. It is believed that this review can inspire multidisciplinary collaboration and accelerate the development of next-generation MNDDS.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e02178"},"PeriodicalIF":9.6,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145068747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced Multifunctional Bioactive Glass Nanoparticles: from Tissue Repair to Theranostics. 先进的多功能生物活性玻璃纳米颗粒：从组织修复到治疗学。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-15 DOI: 10.1002/adhm.202502192

Yanzi Zhao, Weipeng Qiang, Bo Lei

引用次数: 0

Bioinspired Magnetic Janus Core-Shell Micromotors for Delivery of Stem Cells and Vascular Endothelial Growth Factor in Bone Regeneration. 用于骨再生干细胞和血管内皮生长因子输送的生物启发磁Janus核壳微型马达。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-15 DOI: 10.1002/adhm.202501294

Lei Yang, Xiuling He, Wenzhao Li, Luoran Shang

{"title":"Bioinspired Magnetic Janus Core-Shell Micromotors for Delivery of Stem Cells and Vascular Endothelial Growth Factor in Bone Regeneration.","authors":"Lei Yang, Xiuling He, Wenzhao Li, Luoran Shang","doi":"10.1002/adhm.202501294","DOIUrl":"https://doi.org/10.1002/adhm.202501294","url":null,"abstract":"Bone defect poses a major challenge for both patients and clinicians. Stem cell therapy based on multifunctional cell delivery microcarriers is a prospective approach for bone repair. However, the realization of efficient and precise stem cell delivery remains to be developed. Here, a bio-inspired magnetic Janus micromotor (MJM) stem cells delivery carrier is proposed for bone repair. The MJM carrier consists of an alginate shell and a solid/aqueous Janus core with different properties for the delivery of stem cells and vascular endothelial growth factor (VEGF). The solid core consists of photopolymerized silk fibroin methacrylate (SFMA) along with magnetic Fe3O4@MgSiO3, which effectively improves the drug release efficiency of VEGF. The aqueous core provides a favorable microenvironment for stem cell proliferation and delivery, which avoids mechanical damage and improves the cell implantation rate. The magnetic Fe3O4@MgSiO3 nanoparticles enable rapid collection of MJM and accurate localization of MJM to the bone defect area with the assistance of a magnet. Based on these features, it is verified that the MJM stem cell microcarriers have favorable angiogenic and osteogenic properties for bone repair. These characteristics indicate that MJM is an effective carrier for stem cell delivery, and is expected to be a viable option for clinically relevant diseases therapy.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e01294"},"PeriodicalIF":9.6,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145068782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breaking Age-Impaired Bone Healing Challenge: Smart Hydrogel-Coated Implant Reprograms Aging Bone Microenvironments via Senolytic and Pro-Angiogenic Dual Therapy. 打破年龄受损的骨愈合挑战：智能水凝胶涂层种植体通过抗衰老和促血管生成双重治疗重新编程老化的骨微环境。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-14 DOI: 10.1002/adhm.202501928

Yi Wu, Shuohan He, Meng Li, Yan Li, Shaopeng Liu, Hongwei Xiong, Qianxiang Meng, Peng Liu, Kaiyong Cai

{"title":"Breaking Age-Impaired Bone Healing Challenge: Smart Hydrogel-Coated Implant Reprograms Aging Bone Microenvironments via Senolytic and Pro-Angiogenic Dual Therapy.","authors":"Yi Wu, Shuohan He, Meng Li, Yan Li, Shaopeng Liu, Hongwei Xiong, Qianxiang Meng, Peng Liu, Kaiyong Cai","doi":"10.1002/adhm.202501928","DOIUrl":"https://doi.org/10.1002/adhm.202501928","url":null,"abstract":"In the aging microenvironment, the decreased ability of bone regeneration seriously affects the efficiency of bone defect repair. To address this, a smart, reactive oxygen species (ROS)-responsive hydrogel-coated titanium implant loaded with copper-dihydromyricetin nanoparticles (CuDHM NPs) is developed. This implant synergistically modulates the bone repair microenvironment through dual mechanisms: anti-senescence and pro-angiogenesis. The hydrogel coating enables sustained, responsive release of CuDHM under oxidative stress conditions linked to cellular senescence. This mechanism effectively scavenges excessive intracellular and extracellular ROS accumulation, restores mitochondrial metabolic function, and directly decelerates the senescence of mesenchymal stem cells (MSCs). Moreover, the material induces the upregulation of key signaling molecules such as vascular endothelial growth factor (VEGF), promotes the formation of type H vessels, and synergistically ameliorates MSCs' senescence by modulating the extracellular matrix microenvironment. Notably, the formation of type H vessels itself enhances bone tissue regeneration. In vivo animal experiments demonstrate that the material accelerates bone repair by restoring local microenvironmental homeostasis and promoting vascularization. In summary, this study presents a novel implant that reprograms the microenvironment to combat age-related bone healing issues by addressing both cellular senescence and poor vascularization, offering a promising strategy for enhanced recovery in elderly patients with strong clinical potential.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e01928"},"PeriodicalIF":9.6,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosome-Engineered Afterglow Probe for Targeted Imaging of Atherosclerotic Plaques In Vivo. 外泌体工程余辉探针用于体内动脉粥样硬化斑块的靶向成像。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-14 DOI: 10.1002/adhm.202503261

Yating He, Xintong Dong, Di Zhao, Chen Han, Zhihui Jia, Hong-Min Meng, Zhaohui Li

{"title":"Exosome-Engineered Afterglow Probe for Targeted Imaging of Atherosclerotic Plaques In Vivo.","authors":"Yating He, Xintong Dong, Di Zhao, Chen Han, Zhihui Jia, Hong-Min Meng, Zhaohui Li","doi":"10.1002/adhm.202503261","DOIUrl":"https://doi.org/10.1002/adhm.202503261","url":null,"abstract":"Atherosclerosis is considered one of the primary causes of cardiovascular diseases, and thus assessing the vulnerability of atherosclerotic plaques is significant for timely clinical intervention. However, current probes for assessing vulnerable plaques face the dual challenges of insufficient imaging contrast and limited targeting specificity. Here, these limitations are addressed by applying an exosome-engineered afterglow nanoprobe, which is developed by integrating M2 macrophage-derived exosomes (M2 exosomes) with an afterglow luminescent agent for high-contrast atherosclerotic plaque imaging. The nanoprobe features: 1) M2 exosome-mediated active targeting performance to foam cell-enriched vulnerable plaques through intrinsic inflammation tropism and 2) reactive oxygen species-responsive afterglow amplification via H2O2-triggered chemically initiated energy transfer between the oxalate and afterglow agent. This probe could differentiate foam cells from normal macrophages (1.7-fold higher uptake). In vivo results show that it precisely localizes in the plaques of ApoE-/- mice, demonstrating exceptional specificity. Moreover, imaging with the probe enables the visualization of carotid atherosclerotic plaques in living mouse models, with superior imaging contrast (2.25-fold higher) compared with fluorescence signal. This targeted afterglow imaging agent represents a promising strategy for the non-invasive identification of high-risk atherosclerotic plaques, offering significant potential for guiding precision therapies and improving cardiovascular outcomes.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e03261"},"PeriodicalIF":9.6,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functionalized Decalcified Bone Matrix Scaffold for Cartilage and Bone Regeneration and Repair of Osteochondral Composite Defects. 功能化脱钙骨基质支架用于软骨和骨再生及骨软骨复合缺损修复。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-14 DOI: 10.1002/adhm.202501432

Genke Li, Jie Zhu, Wenjuan Sun, Qixin Zhang, Zheng Ci, Wenxing Guan, Yunshu Yang, Zhe Cao, Yaru Chu, Zhanyu Chang, Wenqiang Zhang, Huitang Xia, Guangdong Zhou, Wenjie Ren

{"title":"Functionalized Decalcified Bone Matrix Scaffold for Cartilage and Bone Regeneration and Repair of Osteochondral Composite Defects.","authors":"Genke Li, Jie Zhu, Wenjuan Sun, Qixin Zhang, Zheng Ci, Wenxing Guan, Yunshu Yang, Zhe Cao, Yaru Chu, Zhanyu Chang, Wenqiang Zhang, Huitang Xia, Guangdong Zhou, Wenjie Ren","doi":"10.1002/adhm.202501432","DOIUrl":"https://doi.org/10.1002/adhm.202501432","url":null,"abstract":"Decellularized Wharton's jelly (DWJ) and decalcified bone matrix (DBM) are naturally derived biomaterials that serve as ideal scaffolds for repairing articular defects. DWJ secretes various bioactive factors that promote cartilage regeneration. However, it lacks sufficient mechanical strength to provide adequate support. DBM has an appropriate mechanical strength and osteogenic inductivity. However, its excessively large pore size results in low cell adhesion rates. To address these challenges, in this study, a functionalized decalcified bone matrix (FDBM) scaffold is fabricated by loading DWJ mixed with gelatin (GT) onto DBM, which is followed by freeze-drying and cross-linking. In vitro, the FDBM demonstrates the ability to induce bone marrow mesenchymal stem cells (BMSCs) to differentiate into chondrocytes and regenerate high-quality cartilage-like tissues within the cartilage microenvironment. In vivo, the cartilage tissue, regenerated from the BMSCs loaded onto FDBM, exhibited a robust endochondral ossification effect in the non-cartilage environments. Furthermore, FDBM offers chondrogenic and osteogenic microenvironments similar to natural joint tissue and has successfully repaired articular osteochondral defects in a rabbit model of osteochondral composite defects. This functional composite scaffold offers a new strategy for the clinical treatment of osteochondral composite defects.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e01432"},"PeriodicalIF":9.6,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Redox-Active Nanozymes in Metabolic Modulation for Precision Therapeutics. 氧化还原活性纳米酶在精确治疗中的代谢调节。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-13 DOI: 10.1002/adhm.202502110

Wenying Zhang, Meifang Wang, Ping'an Ma, Jun Lin

{"title":"Redox-Active Nanozymes in Metabolic Modulation for Precision Therapeutics.","authors":"Wenying Zhang, Meifang Wang, Ping'an Ma, Jun Lin","doi":"10.1002/adhm.202502110","DOIUrl":"https://doi.org/10.1002/adhm.202502110","url":null,"abstract":"Nanozyme metabolic therapy leverages the catalytic activity of artificial enzymes to reprogram dysregulated metabolic pathways at disease sites, offering a targeted approach to restore physiological homeostasis. This review uniquely focuses on redox-active nanozymes and their roles in modulating key metabolic circuits (e.g., glucose, lactate, lipid, and xanthine metabolism) across diverse pathological contexts. While cancer remains the most extensively explored domain, emerging uses of nanozymes in bacterial infections, cardiovascular diseases, diabetes, obesity, and inflammatory disorders, where mechanistic understanding is still evolving, are also highlighted. By selectively altering metabolite levels and enzymatic activities, nanozymes enable precise metabolic control with high catalytic specificity. Nanozymes are systematically categorized based on their redox mechanisms and the metabolic pathways they influence, and discuss representative examples across disease contexts. Finally, the review concludes by outlining current challenges and emphasizing the translational potential of nanozymes as programmable metabolic modulators, aiming to expand their impact beyond oncology into broader clinical applications.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e02110"},"PeriodicalIF":9.6,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145051473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional Hydrogel Dressing Based on Glycosylated Collagen-Curcumin Nanoparticles Effectively Accelerates Wound Healing. 基于糖基化胶原-姜黄素纳米颗粒的多功能水凝胶敷料有效加速伤口愈合。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-13 DOI: 10.1002/adhm.202500554

Jing-Jing Fu, Si-Yi Mei, Qi-Cheng Zhang, Xiang-Yu Fu, Jing-Chu Zhong, Jie Deng, Qiao-Bo Zhang, Xiao-Yang Bai, Fan-Yu He, Jun-Xin Wu, Yue-Wen Chen

{"title":"Multifunctional Hydrogel Dressing Based on Glycosylated Collagen-Curcumin Nanoparticles Effectively Accelerates Wound Healing.","authors":"Jing-Jing Fu, Si-Yi Mei, Qi-Cheng Zhang, Xiang-Yu Fu, Jing-Chu Zhong, Jie Deng, Qiao-Bo Zhang, Xiao-Yang Bai, Fan-Yu He, Jun-Xin Wu, Yue-Wen Chen","doi":"10.1002/adhm.202500554","DOIUrl":"https://doi.org/10.1002/adhm.202500554","url":null,"abstract":"Multifunctional hydrogels have aroused great interest in accelerating wound healing. In this study, a hydrogel dressing with antioxidant, antibacterial, anti-inflammatory, and wound healing properties is developed using xylose (Xy) glycated Chinese giant salamander collagen (CGSPXy), curcumin (Cur), sodium alginate (SA), and chitosan (CS). Specifically, the CGSP/CGSPXy-Cur nanoparticle is mixed with SA through hydrogen bonding interactions to form a hydrogel framework. Subsequently, the CGSP/CGSPXy-Cur-SA is immersed in a solution containing Ca2⁺ and CS, forming an ion-crosslinked semi-interpenetrating double-network hydrogel. Notably, CGSPXy synergized with Cur reduced the swelling ratio while enhancing the thermal stability, rheological properties, adhesion performance, and tensile strength of hydrogels. In vitro experiments demonstrated that hydrogels constructed with CGSPXy-Cur nanoparticles exhibited sustained Cur release, along with excellent blood compatibility, clotting properties, antioxidant, and antibacterial activity. Also, CGSPXy synergized with Cur has been proven to effectively promote wound healing by promoting collagen deposition, new blood vessels, myofibroblast generation, and reducing the production of proinflammatory factors (TNF-α and IL-6). This study provided a promising strategy for collagen-based hydrogel as a sustainable solution for wound care.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e00554"},"PeriodicalIF":9.6,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145051405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0