Advanced Healthcare Materials最新文献_第9页

Organoids of Musculoskeletal System for Disease Modeling, Drug Screening, and Regeneration.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-11-28 DOI: 10.1002/adhm.202402444

Weicheng Chen, Dachuan Liu, Kai Lu, Mengping Xu, Di Li, Wei Yan, Song Chen, Bin Li

引用次数: 0

Dual-Enhanced Nanohybrids for Synergistic Photothermal and Photodynamic Therapy in Cancer Treatment with Immune Checkpoint Inhibitors.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-11-28 DOI: 10.1002/adhm.202403570

Dabin Lee, Hyungjin Sun, Jieun Bang, Tae-Young Heo, Duong Thi-Thuy Pham, Jong Dae Jang, Young Soo Han, Tae Joo Shin, Soo-Hyung Choi, JaeHong Park, Junsang Doh, Juhyun Park

{"title":"Dual-Enhanced Nanohybrids for Synergistic Photothermal and Photodynamic Therapy in Cancer Treatment with Immune Checkpoint Inhibitors.","authors":"Dabin Lee, Hyungjin Sun, Jieun Bang, Tae-Young Heo, Duong Thi-Thuy Pham, Jong Dae Jang, Young Soo Han, Tae Joo Shin, Soo-Hyung Choi, JaeHong Park, Junsang Doh, Juhyun Park","doi":"10.1002/adhm.202403570","DOIUrl":"https://doi.org/10.1002/adhm.202403570","url":null,"abstract":"This study presents a nanohybrid that simultaneously improves both photothermal (PT) and photodynamic (PD) effects for cancer therapy. The conjugated polymer nanoparticle (CPN) comprises of p-type conjugated polymer as a photosensitizer, charge donor, and PT agent, n-type conjugated polymer as a charge acceptor and PD agent, and Au nanoparticles (NPs) as a PT agent. This nanohybrid is assembled through a film dispersion process using a hydrophobically modified phospholipid, producing a high yield of uniform hybrid NPs in a short timeframe, and displays exceptional photothermal and photodynamic effects, when activated at a single near-infrared wavelength. Photophysical analysis indicates that the inclusion of Au NPs enhances nonradiative exciton relaxation, while the incorporation of a n-type conjugated polymer boosts photoinduced charge transfer and potentially contributes to the charge-recombination mediated triplet-state formation for an enhanced generation of reactive oxygen species. During phototherapy, the nanohybrid demonstrates the most effective suppression of primary tumor growth and significantly boosts anti-tumor immune responses owing to its simultaneous photothermal and photodynamic effects. Furthermore, when combined with immune checkpoint inhibitors, nanohybrid treatment minimizes tumor sizes while maximizing survival rates in mice. Thus, the nanohybrid represents a promising nanoplatform for combination phototherapy in cancer treatment.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403570"},"PeriodicalIF":10.0,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Near-Infrared Two-Photon J-Aggregation-Induced Organic Fluorescent Dots with Large Stokes-Shift for Ratiometric Imaging of Hypochlorous Acid in Living Cells and Brains of AD Mice.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-11-28 DOI: 10.1002/adhm.202402779

Rui Huang, Ziwei Zhang, Zhen Shi, Yumeng Yang, Junyong Sun, Feng Gao

{"title":"Near-Infrared Two-Photon J-Aggregation-Induced Organic Fluorescent Dots with Large Stokes-Shift for Ratiometric Imaging of Hypochlorous Acid in Living Cells and Brains of AD Mice.","authors":"Rui Huang, Ziwei Zhang, Zhen Shi, Yumeng Yang, Junyong Sun, Feng Gao","doi":"10.1002/adhm.202402779","DOIUrl":"https://doi.org/10.1002/adhm.202402779","url":null,"abstract":"Alzheimer's disease (AD) is characterized by multiple toxicity from various biomarkers, and it is very important to monitor the fluctuation of biomarker level in brain tissues to track its early onset, illness progression, and therapeutic effect. Hypochlorous acid (HOCl) is confirmed to be a reliable biomarker to extend the scope of diagnosis. However, the practical applications of the developed conjugated small molecule fluorescent probes for detecting HOCl are often restricted to a large extent by their low solubility, aggregation-caused quenching (ACQ), unsatisfactory fluorescence brightness, small Strokes-shift, and lack of self-correcting ratiometric emitters. In this study, a J-aggregation-induced organic fluorescent dot (PBT dots), is reported which is facilely developed by co-assembling newly designed organic molecule PBT with polymer DSPE-PEG, for ClO- imaging in living brain-derived Endothelial (bEnd.3) cells and brain tissues of AD mice. The developed two-photon PBT dots show NIR emission at 715 nm, large Stokes-shift of 245 nm, quick response within 2 s, ratiometric sensing properties, and favorable blood-brain barrier (BBB) penetrate ability. The results demonstrate that HOCl level is elevated in AD mouse brain, and PBT dot holds promise as an imaging probe to understand and reveal AD pathologies.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2402779"},"PeriodicalIF":10.0,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thioether-Functionalized Cellulose for the Fabrication of Oxidation-Responsive Biomaterial Coatings and Films. 硫醚官能化纤维素用于制造氧化反应性生物材料涂层和薄膜。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-11-27 DOI: 10.1002/adhm.202403021

Eric M DuBois, Kate E Herrema, Matthew G Simkulet, Laboni F Hassan, Payton R O'Connor, Riya Sen, Timothy M O'Shea

{"title":"Thioether-Functionalized Cellulose for the Fabrication of Oxidation-Responsive Biomaterial Coatings and Films.","authors":"Eric M DuBois, Kate E Herrema, Matthew G Simkulet, Laboni F Hassan, Payton R O'Connor, Riya Sen, Timothy M O'Shea","doi":"10.1002/adhm.202403021","DOIUrl":"https://doi.org/10.1002/adhm.202403021","url":null,"abstract":"Biomaterial coatings and films can prevent premature failure and enhance the performance of chronically implanted medical devices. However, current hydrophilic polymer coatings and films have significant drawbacks, including swelling and delamination. To address these issues, hydroxyethyl cellulose is modified with thioether groups to generate an oxidation-responsive polymer, HECMTP. HECMTP readily dissolves in green solvents and can be fabricated as coatings or films with tunable thicknesses. HECMTP coatings effectively scavenge hydrogen peroxide, resulting in the conversion of thioether groups to sulfoxide groups on the polymer chain. Oxidation-driven, hydrophobic-to-hydrophilic transitions that are isolated to the surface of HECMTP coatings under physiologically relevant conditions increase wettability, decrease stiffness, and reduce protein adsorption to generate a non-fouling interface with minimal coating delamination or swelling. HECMTP can be used in diverse optical applications and permits oxidation-responsive, controlled drug release. HECMTP films are non-resorbable in vivo and evoke minimal foreign body responses. These results highlight the versatility of HECMTP and support its incorporation into chronically implanted medical devices.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403021"},"PeriodicalIF":10.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142737768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of pH-Responsive Surface Functionalized Titanium Screws in Treating Implant-associated S. aureus Osteomyelitis with Biofilms Formation. pH值响应型表面功能化钛螺钉在治疗种植体相关金黄色葡萄球菌骨髓炎及生物膜形成中的疗效。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-11-27 DOI: 10.1002/adhm.202403261

Hang Zhou, Youliang Ren, Kaixiong Zou, Ying Jin, Hang Liu, Haitao Jiang, Lei Shi, Xiaomin Sheng, Jason Weeks, Hannah Wang, Thomas Xue, Edward M Schwarz, Chao Xie, Zhongliang Deng, Lin Wang, Lei Chu

{"title":"Efficacy of pH-Responsive Surface Functionalized Titanium Screws in Treating Implant-associated S. aureus Osteomyelitis with Biofilms Formation.","authors":"Hang Zhou, Youliang Ren, Kaixiong Zou, Ying Jin, Hang Liu, Haitao Jiang, Lei Shi, Xiaomin Sheng, Jason Weeks, Hannah Wang, Thomas Xue, Edward M Schwarz, Chao Xie, Zhongliang Deng, Lin Wang, Lei Chu","doi":"10.1002/adhm.202403261","DOIUrl":"https://doi.org/10.1002/adhm.202403261","url":null,"abstract":"Implant-associated Staphylococcus aureus (S. aureus) osteomyelitis (IASO) leads to high orthopedic implant failure rates due to the formation of Staphylococcal abscess community within the bone marrow and bacterial colonization in the osteocyte lacuno-canalicular network (OLCN). To address this, antimicrobial peptides (HHC36)-loaded titania nanotubes (NTs) are developed on titanium screws (Ti-NTs-P-A), which integrate pH-responsive polymethacrylic acid to control HHC36 release for eradicating bacteria in IASO. Colony-forming unit assay confirmed that Ti-NTs-P-A screws maintained sustainable antibacterial effectiveness, killing over 65% of S. aureus even after multiple bacterial solution replacements. Notably, Ti-NTs-P-A screws exhibit significant pH-responsive HHC36 release behavior and bactericidal activity, consistent with the phenotype of peptides-killed bacteria from scanning electron microscopy. Transcriptome sequencing results reveal that Ti-NTs-P-A screws interfered with ribosome formation and disrupted the arginine biosynthesis, which is crucial for bacterial survival in acidic environments. In the non-infected implant model, the bone-implant contact ratio of the Ti-NTs-P-A screw is 2.3 times that of the clinically used titanium screw. In an IASO model, Ti-NTs-P-A screws effectively eradicated bacteria within the OLCN, achieving an 80% infection control rate and desirable osteointegration. Collectively, Ti-NTs-P-A screws with pH-responsive antibacterial properties exhibit great potential for eradicating bacteria and achieving osseointegration in IASO.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403261"},"PeriodicalIF":10.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142737862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional Adhesive Hydrogels: From Design to Biomedical Applications. 多功能粘合水凝胶：从设计到生物医学应用。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-11-27 DOI: 10.1002/adhm.202403734

Shaoxin Tang, Keru Feng, Rui Yang, Yang Cheng, Meiyue Chen, Hui Zhang, Nianyuan Shi, Zhao Wei, Hui Ren, Yufei Ma

{"title":"Multifunctional Adhesive Hydrogels: From Design to Biomedical Applications.","authors":"Shaoxin Tang, Keru Feng, Rui Yang, Yang Cheng, Meiyue Chen, Hui Zhang, Nianyuan Shi, Zhao Wei, Hui Ren, Yufei Ma","doi":"10.1002/adhm.202403734","DOIUrl":"https://doi.org/10.1002/adhm.202403734","url":null,"abstract":"Adhesive hydrogels characterized by structural properties similar to the extracellular matrix, excellent biocompatibility, controlled degradation, and tunable mechanical properties have demonstrated significant potential in biomedical applications, including tissue engineering, biosensors, and drug delivery systems. These hydrogels exhibit remarkable adhesion to target substrates and can be rationally engineered to meet specific requirements. In recent decades, adhesive hydrogels have experienced significant advancements driven by the introduction of numerous multifunctional design strategies. This review initially summarizes the chemical bond-based design strategies for tissue adhesion, encompassing static covalent bonds, dynamic covalent bonds, and non-covalent interactions. Subsequently, the multiple functionalities imparted by these diverse design strategies, including highly stretchable and tough performances, responsiveness to microenvironments, anti-freezing/heating properties, conductivity, antibacterial activity, and hemostatic properties are discussed. In addition, recent advances in the biomedical applications of adhesive hydrogels, focusing on tissue repair, drug delivery, medical devices, and wearable sensors are reviewed. Finally, the current challenges are highlighted and future trends in this rapidly evolving field are discussed.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403734"},"PeriodicalIF":10.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142737864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasound-Triggered Mg²⁺ Blasting Release Hydrogel Microspheres for Promoting Bone Reconstruction. 超声触发的 Mg2+ 爆破释放水凝胶微球用于促进骨重建

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-11-26 DOI: 10.1002/adhm.202402935

Wenlin Huang, Xu Wang, Zhenyu Zhao

{"title":"Ultrasound-Triggered Mg2+ Blasting Release Hydrogel Microspheres for Promoting Bone Reconstruction.","authors":"Wenlin Huang, Xu Wang, Zhenyu Zhao","doi":"10.1002/adhm.202402935","DOIUrl":"https://doi.org/10.1002/adhm.202402935","url":null,"abstract":"Mg2+ (Magnesium ion) can affect bone tissue metabolism by regulating related signaling pathways in bone metabolism. However, how to realize precise controlled release of Mg2+ in bone regeneration treatment still presents a challenge. Herein, for the first time, the GelMA-BP (Gelatin Methacryloyl-Bisphosphonate) and the composite nano-bubble system are fused to construct the Mg2+ blasting controlled-release hydrogel microspheres, the stability of the nano-bubbles in the microspheres is enhanced through metal coordination complexation, and the burst of the nano-bubbles is controlled by using ultrasonic cavitation to achieve the precise controlled release of Mg2+, ultimately effectively promoting bone reconstruction. First, GelMA-BP composite is prepared by Schiff base reaction. Second, the nanobubble BP (Bisphosphonate) system is constructed, and Mg2+ is combined with the ligand coordination to prepare the composite nanobubble system. Thirdly, through Mg2+ co-coordination, the ultrasound-triggered Mg2+ blasting controlled release microspheres were prepared to achieve bone repair. Overall, this innovative strategy effectively solves the problem of accurate controlled release of Mg2+, and finally effectively activates in situ bone tissue regeneration.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2402935"},"PeriodicalIF":10.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142724391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coaxial Electrospun Nanofibrous Membranes as Dual-Functional Biomimetic Tendon Sheath for Tendon Repair and Anti-Peritendinous Adhesion. 同轴电纺纳米纤维膜作为双功能仿生肌腱鞘用于肌腱修复和抗肌腱膜下粘连

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-11-26 DOI: 10.1002/adhm.202402074

Qiao Yang, Jianfeng Li, Hongfang Meng, Yongdi Wang, Lanlan Hu, Weiwei Su, Jie Xu, Juedong Hou, Rui Zhao, Zihan Wang, Kairui Zhang, Yaobin Wu, Ling Wang

{"title":"Coaxial Electrospun Nanofibrous Membranes as Dual-Functional Biomimetic Tendon Sheath for Tendon Repair and Anti-Peritendinous Adhesion.","authors":"Qiao Yang, Jianfeng Li, Hongfang Meng, Yongdi Wang, Lanlan Hu, Weiwei Su, Jie Xu, Juedong Hou, Rui Zhao, Zihan Wang, Kairui Zhang, Yaobin Wu, Ling Wang","doi":"10.1002/adhm.202402074","DOIUrl":"https://doi.org/10.1002/adhm.202402074","url":null,"abstract":"Tendon injuries often exhibit limited healing capacity, frequently complicated by peritendinous adhesion, posing a substantial challenge in clinical tendon repair. Although present biomaterial-based membranes offer a promising strategy for tendon treatment, their clinical application is hindered by inflammation-induced adhesion. Herein, this study presents a dual-functional biomimetic tendon sheath based on a coaxial electrospun nanofibrous membrane for enhancing tendon repair and simultaneously preventing peritendinous adhesion. This nanofibrous membrane is fabricated using a coaxial electrospinning method, encapsulating celecoxib-loaded polycaprolactone (PCL) within gelatin methacryloyl (GelMA) shell. Both in vitro and in vivo analysis results demonstrated that such coaxial biomimetic tendon sheath enhanced tenogenic differentiation of tendon stem/progenitor cells (TSPCs) due to nanofibrous GelMA shell providing a suitable microenvironment surface. Simultaneously, the sustained release of celecoxib (CEL) from the core is able to significantly decrease the expression of inflammatory cytokines. Notably, in vivo assessments in animal models with patellar tendon defects revealed significant reductions in peritendinous adhesion, leading to further enhancement in tendon repair. These results underscore the potential of the coaxial nanofibrous membrane as a dual-functional biomimetic tendon sheath, offering a promising avenue for the long-term management of tendon injuries.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2402074"},"PeriodicalIF":10.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142724390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antitumor Activity of a Bispecific Chimera Targeting EGFR and Met in Gefitinib-Resistant Non-Small Cell Lung Cancer. 靶向表皮生长因子受体和 Met 的双特异性嵌合体在吉非替尼耐药的非小细胞肺癌中的抗肿瘤活性

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-11-25 DOI: 10.1002/adhm.202402884

Ya Wang, Guixi Zhang, Zhilan Zhou, Ning Zhang, Hang Jiang, Yichang Liu, Ting Fu, Yingdi Zhu, Juan Li

{"title":"Antitumor Activity of a Bispecific Chimera Targeting EGFR and Met in Gefitinib-Resistant Non-Small Cell Lung Cancer.","authors":"Ya Wang, Guixi Zhang, Zhilan Zhou, Ning Zhang, Hang Jiang, Yichang Liu, Ting Fu, Yingdi Zhu, Juan Li","doi":"10.1002/adhm.202402884","DOIUrl":"https://doi.org/10.1002/adhm.202402884","url":null,"abstract":"Non-small cell lung cancers (NSCLC) frequently acquire resistance to tyrosine kinase inhibitors (TKI) due to epidermal growth factor receptor (EGFR) mutation or activation of the bypass pathway involving mesenchymal-epithelial transition factor (Met). To address this challenge, a bispecific nanobody-aptamer chimera is designed to target mutated EGFR and Met simultaneously to block their cross-talk in NSCLC. The EGFR-Met chimera is cost-effectively engineered using microbial transglutaminase and click chemistry strategies. With enhanced binding affinity toward the target proteins, the as-developed chimera inhibits efficiently the cross-talk between signaling pathways associated with EGFR and Met. This inhibition leads to the suppression of downstream pathways, such as Erk and Akt, and induces upregulation of cell cycle arrest-related proteins, including Rb, p21, and p27. Additionally, the chimera activates the caspase-dependent apoptotic signaling pathway. Consequently, it inhibits cell migration, induces cell death, and causes cell cycle arrest in vitro. Moreover, the chimera exhibits significant antitumor efficacy in drug-resistant xenograft mouse models, showcasing improved tissue penetration and low toxicity. This study accentuates the potential of the bispecific EGFR-Met chimera as a promising therapeutic option for NSCLC resistant to EGFR TKIs.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2402884"},"PeriodicalIF":10.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142714897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How the Versatile Self-Assembly in Drug Delivery System to Afford Multimodal Cancer Therapy? 给药系统中的多功能自组装如何实现癌症的多模式治疗？

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-11-25 DOI: 10.1002/adhm.202403715

Yuqi Cao, Xiaomin Zhao, Yuhang Miao, Xin Wang, Dawei Deng

{"title":"How the Versatile Self-Assembly in Drug Delivery System to Afford Multimodal Cancer Therapy?","authors":"Yuqi Cao, Xiaomin Zhao, Yuhang Miao, Xin Wang, Dawei Deng","doi":"10.1002/adhm.202403715","DOIUrl":"https://doi.org/10.1002/adhm.202403715","url":null,"abstract":"The rapid development of self-assembly technology during the past few decades has effectively addressed plenty of the issues associated with carrier-based drug delivery systems, such as low loading efficiency, complex fabrication processes, and inherent toxicity of carriers. The integration of nanoscale delivery systems with self-assembly techniques has enabled efficient and targeted self-administration of drugs, enhanced bioavailability, prolonged circulation time, and controllable drug release. Concurrently, the limitations of single-mode cancer treatment, including low bioavailability, poor therapeutic outcomes, and significant side effects, have highlighted the urgent need for multimodal combined antitumor therapies. Set against the backdrop of multimodal cancer therapy, this review summarizes the research progress and applications of a large number of self-assembled drug delivery platforms, including natural small molecule self-assembled, carrier-free self-assembled, amphiphilic polymer-based self-assembled, peptide-based self-assembled, and metal-based self-assembled nano drug delivery systems. This review particularly analyzes the latest advances in the application of self-assembled nano drug delivery platforms in combined antitumor therapies mediated by chemotherapy, phototherapy, radiotherapy, sonodynamic therapy, and immunotherapy, providing innovative research insights for further optimization and expansion of self-assembled nano drug delivery systems in the clinical translation and development of antitumor combined therapy.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403715"},"PeriodicalIF":10.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142714898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0