Advanced Healthcare Materials最新文献_第8页

A MicroRNA and ROS-Scavenger Co-Loaded Nanogel for in Situ Macrophage Regulation and MR-Visualized Treatment of Atherosclerosis. MicroRNA和ros清除剂共载纳米凝胶用于原位巨噬细胞调节和动脉粥样硬化的mr可视化治疗。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-18 DOI: 10.1002/adhm.202502534

Sunli Wan, Yuanyuan Guo, Xinhua Liu, Yu Huang, Tingting Yao, Mingkang Wang, Qiang Zhang, Xiaoer Wei, Xuehao Yu, Jiajie Hu, Yuehua Li, Lei Zhang

{"title":"A MicroRNA and ROS-Scavenger Co-Loaded Nanogel for in Situ Macrophage Regulation and MR-Visualized Treatment of Atherosclerosis.","authors":"Sunli Wan, Yuanyuan Guo, Xinhua Liu, Yu Huang, Tingting Yao, Mingkang Wang, Qiang Zhang, Xiaoer Wei, Xuehao Yu, Jiajie Hu, Yuehua Li, Lei Zhang","doi":"10.1002/adhm.202502534","DOIUrl":"https://doi.org/10.1002/adhm.202502534","url":null,"abstract":"Atherosclerosis is a major pathophysiological factor in cardiovascular disease and is characterized by inflammatory responses and oxidative stress in plaques. Developing plaque microenvironment regulators for effective atherosclerosis treatment remains a great challenge owing to the pathological complexity, individual heterogeneity, and the limited efficiency of current medications. Herein, the integration of macrophage regulators and reactive oxygen species (ROS) scavengers into a nucleic acid nanogel platform is proposed for a highly efficient visualized treatment of atherosclerosis. As a proof-of-concept, an ROS scavenger with paramagnetic functionality, 2,2,6,6-tetramethylpiperidinyl-1-oxide (TEMPO), is selected for site-specific grafting onto single DNA strands via phosphorothioate groups to obtain TEMPO-DNA conjugates, which are subsequently assembled into TEMPO-grafted Y-shaped blocks with magnetic resonance imaging (MRI) capacity. Additionally, microRNA (miR-146a-5p) with macrophage-reprogramming ability is used as a crosslinker to integrate with the TEMPO-grafted blocks for preparing the multifunctional nanogel. With TEMPO inside, the nanoplatform enabled dynamic monitoring of disease progression and visualization of plaque treatment. The prepared drug co-delivery nanogels significantly relieved oxidative stress and regulated the inflammatory state of macrophages, leading to the remarkable regression and stabilization of plaques. Through its MRI capacity and synergistic therapeutic functionalities, this easy-to-prepare nanogel system provides a promising alternative strategy for imaging and visualizing the treatment of atherosclerotic plaques.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e02534"},"PeriodicalIF":9.6,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineered Curcumin/Strontium Nanoparticles Grafted with K6-CAMEL0 Peptide for the Multifaceted Treatment of Bone Infections. K6-CAMEL0肽的工程姜黄素/锶纳米颗粒对骨感染的多方面治疗。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-17 DOI: 10.1002/adhm.202503470

Zeyu Shou, Dong Yang, Yewen Liu, Jiawei Yu, Jiali Shou, Ming Cai, Lianxin Li, Shuohui Yuan, Xiufeng Wang

{"title":"Engineered Curcumin/Strontium Nanoparticles Grafted with K6-CAMEL0 Peptide for the Multifaceted Treatment of Bone Infections.","authors":"Zeyu Shou, Dong Yang, Yewen Liu, Jiawei Yu, Jiali Shou, Ming Cai, Lianxin Li, Shuohui Yuan, Xiufeng Wang","doi":"10.1002/adhm.202503470","DOIUrl":"https://doi.org/10.1002/adhm.202503470","url":null,"abstract":"To address the clinical challenges of bacterial infection, inflammation, oxidative stress, ischemia-hypoxia, and excessive bone resorption during infected bone therapy, a multifunctional nanoparticle (Cur/Sr@CAMEL0 NPs) is engineered by integrating a self-assembled curcumin-strontium metal-phenolic network core (Cur/Sr NPs) with a hexameric lysine-conjugated antimicrobial peptide (K6-CAMEL0) via surface modification. The resultant nanoparticle exhibits distinctive morphological and structural characteristics, along with favorable cellular compatibility. Functionally, it is demonstrated to exhibit broad-spectrum antibacterial activity, along with inflammation and reactive oxygen species (ROS) scavenging capabilities, pro-angiogenic effects, and significant promotion of necrotic bone resorption and normal bone regeneration. In an infected bone defect animal model, the composite nanoparticle effectively eradicated Staphylococcus aureus （S. aureus） colonization and facilitated the bone regeneration process through single-dose administration. These findings collectively highlight the therapeutic potential of Cur/Sr@CAMEL0 as a multifunctional platform for managing bone infections, offering a promising strategy to address complex challenges in infected bone diseases.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e03470"},"PeriodicalIF":9.6,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the Heterogeneity of Cargo Distribution in the Exogenous Association of Proteins With Extracellular Vesicles. 揭示外源性蛋白质与细胞外囊泡关联中货物分布的异质性。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-16 DOI: 10.1002/adhm.202403991

Karl Normak, Marcell Papp, Carolina Paganini, Andrea Zendrini, Paolo Bergese, Dorothea Pinotsi, Paolo Arosio

{"title":"Unraveling the Heterogeneity of Cargo Distribution in the Exogenous Association of Proteins With Extracellular Vesicles.","authors":"Karl Normak, Marcell Papp, Carolina Paganini, Andrea Zendrini, Paolo Bergese, Dorothea Pinotsi, Paolo Arosio","doi":"10.1002/adhm.202403991","DOIUrl":"https://doi.org/10.1002/adhm.202403991","url":null,"abstract":"Extracellular vesicles (EVs) are emerging as promising nanocarriers for delivering molecules, including proteins. Various exogenous methods are proposed for loading EVs with specific cargo proteins. While the loading yield and the heterogeneity of cargo distribution are crucial quality attributes, a comprehensive quantification of these properties is still lacking. Here, we characterize the heterogeneity of EVs loaded with a model cargo protein, GFP, using various exogenous methods. A combination of biophysical methods is applied to quantify the overall yield and cargo distribution at both the ensemble and single-particle levels. Among the loading methods evaluated, electroporation is most effective for associating GFP with EVs. However, the GFP molecules per vesicle is fewer than 100, representing approximately 4% of the maximum protein capacity that EVs can potentially accommodate. Across all loading methods, the distribution of protein content per vesicle displays significant heterogeneity and follows an exponential decay function, with a higher prevalence of vesicles featuring lower protein content and fewer with higher content. Moreover, loading efficiency increases with EV size. This study shows that overall yields of exogenous loading methods to associate proteins with EVs remain modest and the resulting distribution of cargo proteins associated with EVs is highly heterogeneous.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403991"},"PeriodicalIF":9.6,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermosensitive Hydrogel In Situ Vaccine for Lymph Node Targeting and Enhanced Immunotherapy. 热敏水凝胶原位疫苗用于淋巴结靶向和增强免疫治疗。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-16 DOI: 10.1002/adhm.202502747

Zhengyang Zhao, Hao Liu, Min Li, Yunsheng Zheng, Dongli Qi, Chaoran Chen, Zilu Wang, Lijuan Fu, Shuai Han, Xianzhu Yang, Ziyang Cao, Xiaoqiu Li

{"title":"Thermosensitive Hydrogel In Situ Vaccine for Lymph Node Targeting and Enhanced Immunotherapy.","authors":"Zhengyang Zhao, Hao Liu, Min Li, Yunsheng Zheng, Dongli Qi, Chaoran Chen, Zilu Wang, Lijuan Fu, Shuai Han, Xianzhu Yang, Ziyang Cao, Xiaoqiu Li","doi":"10.1002/adhm.202502747","DOIUrl":"https://doi.org/10.1002/adhm.202502747","url":null,"abstract":"In situ vaccination is a promising strategy for cancer immunotherapy that enables the convenient induction of diverse tumor antigens directly within a host. However, the immunosuppressive tumor microenvironment markedly impairs the antigen-presenting capacity of dendritic cells (DCs), resulting in the inefficient presentation of locally generated antigens and, consequently, suboptimal immune responses. To address this challenge, a localized in situ vaccine platform (Gel/MTO&Snp) designed is developed to actively transport tumor-derived antigens to tumor-draining lymph nodes (tDLNs), thereby eliciting potent antitumor immunity. Gel/MTO&Snp consists of a thermosensitive hydrogel incorporating subsized PEI/CpG nanocomposite particles (Snp, ≈10 nm) and chemotherapeutic agent mitoxantrone (MTO). Upon near-infrared (NIR) laser irradiation, Gel/MTO&Snp simultaneously achieved photothermal and chemotherapeutic effects following local injection, thereby inducing immunogenic cell death and triggering antigen release at tumor sites. These liberated antigens are subsequently adsorbed onto positively charged Snp particles and transported via lymphatic vessels to tDLNs in a size-dependent manner, where they enhanced antigen presentation and immune activation. This targeted antigen delivery markedly promotes DC maturation and effectively stimulates systemic anticancer immunity, providing a novel strategy to optimize the efficacy of in situ cancer vaccines.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e02747"},"PeriodicalIF":9.6,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145073998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond Bioactive Glass Composition: Using Morphology to Improve in Vitro and in Vivo Performance. 超越生物活性玻璃组合物：利用形态学提高体外和体内性能。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-16 DOI: 10.1002/adhm.202502591

Meixin Su, Mert Ergin, Diana Horkavcová, Victoria Horbert, Georg Matziolis, Delia S Brauer

{"title":"Beyond Bioactive Glass Composition: Using Morphology to Improve in Vitro and in Vivo Performance.","authors":"Meixin Su, Mert Ergin, Diana Horkavcová, Victoria Horbert, Georg Matziolis, Delia S Brauer","doi":"10.1002/adhm.202502591","DOIUrl":"https://doi.org/10.1002/adhm.202502591","url":null,"abstract":"Compared to compositional functionalization with therapeutic ions, changing bioactive glass (BG) morphology, i.e., the size, shape, and surface structure of BG specimens, is typically not considered as an influential factor for improving performance. However, it has a large influence on the outcome of various experiments, particularly those studies where the material comes in contact with aqueous solutions, including acellular immersion studies, in vitro experiments using cells or bacteria, and even animal experiments and clinical studies. One major aspect is the surface area to volume ratio, the rate at which ions are released from the glass and surface layers, including apatite layers, forming, can be tailored to subsequently influence the behavior of cells and bacteria. By varying surface roughness or patterning, the orientation and alignment of cells can be controlled or the adhesion of bacteria can be prevented, both in vitro and in vivo. Taken together, this review shows that BG morphology is an important parameter to consider when designing experiments or developing clinical products.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e02591"},"PeriodicalIF":9.6,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145068607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Injectable Deep Eutectic Solvent-Based Ionic Gel With Rapid Gelation and Broad Hemostatic Functionality. 具有快速凝胶化和广泛止血功能的可注射型深共晶溶剂型离子凝胶。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-16 DOI: 10.1002/adhm.202503038

Jia-Yu Yang, En-Yu Zhou, Ting-Hui Cheng, Pin-Hung Liu, Wen-Ching Hsieh, Hui-Ching Cheng, Yi-Kai Hong, Yu-Chen Lin, Yi-Chiung Hsu, Chao-Chun Yang, Chao-Kai Hsu, Li-Chieh Kuo, Shang-Chin Hsieh, Cheng-Hsin Chuang

{"title":"Injectable Deep Eutectic Solvent-Based Ionic Gel With Rapid Gelation and Broad Hemostatic Functionality.","authors":"Jia-Yu Yang, En-Yu Zhou, Ting-Hui Cheng, Pin-Hung Liu, Wen-Ching Hsieh, Hui-Ching Cheng, Yi-Kai Hong, Yu-Chen Lin, Yi-Chiung Hsu, Chao-Chun Yang, Chao-Kai Hsu, Li-Chieh Kuo, Shang-Chin Hsieh, Cheng-Hsin Chuang","doi":"10.1002/adhm.202503038","DOIUrl":"https://doi.org/10.1002/adhm.202503038","url":null,"abstract":"Rapid and effective bleeding control is critical in emergency care and surgical procedures. This study presents a water-free ionic gel based on a deep eutectic solvent (DES), formulated from choline chloride and ethylene glycol, combined with poly(acrylic acid) and viscosity-modulating additives such as hydroxyethyl cellulose (HEC) or collagen (COL). The resulting DES ionic gel exhibits fast in situ gelation within 10 s, high viscosity suitable for injection, and robust tissue adhesion. Mechanical evaluations confirmed adequate stretchability, compressive strength, and toughness. Among all tested formulations, the DES-2% HEC formulation demonstrated optimal performance across swelling, optical clarity (> 90%), and environmental stability (T10%: 131 °C). Antibacterial assays revealed strong bactericidal activity against E. coli and S. aureus, while cytocompatibility tests showed excellent viability and proliferation of fibroblasts and keratinocytes. Hemostatic assessments confirmed reduced clotting time, enhanced red blood cell attachment, and activation of coagulation factor XII. In vivo experiments using rat tail amputation and liver puncture models demonstrated that treatment with DES-2% HEC reduced blood loss and coagulation time by ≈60%-70% compared to the untreated control group, while maintaining excellent biocompatibility. These results highlight the DES ionic gel as a promising multifunctional platform for advanced hemostatic applications.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e03038"},"PeriodicalIF":9.6,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145068772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endometrial ECM Modified Hemispherical Hydrogels Delivering MenSCs Promote the Regeneration of Thin Endometrium. 子宫内膜ECM修饰的半球形水凝胶递送半月板细胞促进薄子宫内膜再生。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-16 DOI: 10.1002/adhm.202501321

Ming Chen, Xuemin Liu, Xiaoxia Song, Xiaofeng Ye, Zeshen Liang, Guoqing Chen, Peixian Cheng, Huihua Yang, Ling Shuai, Dongdong Li, Liping Wang

{"title":"Endometrial ECM Modified Hemispherical Hydrogels Delivering MenSCs Promote the Regeneration of Thin Endometrium.","authors":"Ming Chen, Xuemin Liu, Xiaoxia Song, Xiaofeng Ye, Zeshen Liang, Guoqing Chen, Peixian Cheng, Huihua Yang, Ling Shuai, Dongdong Li, Liping Wang","doi":"10.1002/adhm.202501321","DOIUrl":"https://doi.org/10.1002/adhm.202501321","url":null,"abstract":"Thin endometrium (TE), a major cause of embryo implantation failure, increases the risk of early miscarriage, ectopic pregnancy, and perinatal complications. Owing to the poor utilization and short-term effectiveness of current stem cell therapies, their efficacy in improving reproductive outcomes in patients with TE is limited. Endometrial extracellular matrix (EMECM) modified hemispherical hydrogels (ECMHPs) are developed to deliver menstrual blood-derived stem cells (MenSCs) to promote TE repair. The irregular porous structure on one side of the hemispherical hydrogel microspheres significantly enhances their retention capability on the uterine wall, whereas the bioactive decellularized EMECM promotes MenSCs proliferation and paracrine function. In vitro experiments demonstrate that ECMHPs@MenSCs promote the proliferation of damaged human endometrial stromal cells (HESCs) while inhibiting their fibrosis and apoptosis. In TE rat models, intrauterine transplantation of the ECMHPs delivering MenSCs system (ECMHPs@MenSCs) extends retention time, promotes endometrial thickness by 2.3-fold, increases glandular number by 3.7-fold, inhibits endometrial fibrosis. Additionally, this system improves endometrial regeneration markers and uterine receptivity, and restores fertility, with a mean gestational sac number of 11.0 ± 2.8 compared with only 2.3 ± 2.1 in the untreated group. This study provides an efficient and convenient therapeutic strategy for TE repair and fertility restoration.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e01321"},"PeriodicalIF":9.6,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145068779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanomachine-Based Flexible Bubbles for Alleviating Long QT Syndrome. 基于纳米机器的柔性气泡缓解长QT综合征。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-15 DOI: 10.1002/adhm.202502975

Weixin Wang, Yu Dong, Lin Zhang, Rui Gao, Mingbin Chen, Bei Zhang, Yongheng Du, Lingyan Qiao, Weiwei Qiao, Wenjun Li, Song Qin, Fei Tong

{"title":"Nanomachine-Based Flexible Bubbles for Alleviating Long QT Syndrome.","authors":"Weixin Wang, Yu Dong, Lin Zhang, Rui Gao, Mingbin Chen, Bei Zhang, Yongheng Du, Lingyan Qiao, Weiwei Qiao, Wenjun Li, Song Qin, Fei Tong","doi":"10.1002/adhm.202502975","DOIUrl":"https://doi.org/10.1002/adhm.202502975","url":null,"abstract":"Typically occurring in individuals with a genetic predisposition, long QT syndrome (LQTS) is characterized by prolonged ventricular repolarization (QT interval prolongation) and susceptibility to tip torsion, ventricular tachycardia, ventricular fibrillation, and sudden cardiac death. Currently, treatment options for LQTS include medication and surgery, but these may cause patient discomfort and disease recurrence. In this study, using biocompatible carrier-free nanomachine-based flexible bubbles are proposed to deliver phycocyanin (PC) for heart protection associated with electrophysiological stability in LQTS in vivo in mice. To form the structures, l-arginine (L-Arg) is polymerized with PC through electrostatic interactions, and Au is sputtered onto one side of the surface of L-arg/PC, functioning as a trigger for generating nitric oxide (NO) in the in vivo microenvironment. The asymmetrically released NO cargo provided a means of improving heart function and arrhythmia by delivering PC, and acted as a propellant for transporting the nanomachine to the target site. After accumulating at the site of heart damage, the nanomachines are triggered by reactive oxygen species (ROS). The accumulated nanomachines provided considerable diffusion of PC, which attenuated heart damage. The nanomachines, with ROS-induced targeting and delivery of PC, have immense potential for providing heart protection by modulating myocardial gap junction proteins and the hypoxic environment, and by ameliorating electrical remodeling in LQTS, and therefore may support future clinical testing.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e02975"},"PeriodicalIF":9.6,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145068769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vitro and In Vivo Evaluation of Biodegradation and Osteoinductive Properties of Tantalum and Zinc Co-Doped β-TCP Porous Bioceramic Scaffolds. 钽锌共掺杂β-TCP多孔生物陶瓷支架生物降解和骨诱导性能的体内体外评价。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-15 DOI: 10.1002/adhm.202503406

Jing Luo, Zhi Li, Bowen Zhang, Bo Cheng, Jing Yang, Binbin Li, Xinyu Wang

{"title":"In Vitro and In Vivo Evaluation of Biodegradation and Osteoinductive Properties of Tantalum and Zinc Co-Doped β-TCP Porous Bioceramic Scaffolds.","authors":"Jing Luo, Zhi Li, Bowen Zhang, Bo Cheng, Jing Yang, Binbin Li, Xinyu Wang","doi":"10.1002/adhm.202503406","DOIUrl":"https://doi.org/10.1002/adhm.202503406","url":null,"abstract":"β-Tricalcium phosphate (β-TCP) ceramics suffer from inadequate mechanical strength and uncontrolled degradation in critical bone defect repair. To address this, Tantalum/Zinc co-doped β-TCP （Ta/Zn-β-TCP） porous ceramics are developed via a novel microwave-ultrasound hydrothermal method. Physicochemical analyses confirms successful incorporation of Ta⁵⁺ (2.46 mol%) and Zn2⁺ (2.35 mol%) into the β-TCP lattice without phase alteration, inducing bidirectional lattice distortion that enhances compressive strength by 90% (10.72 ± 0.31 MPa and pure β-TCP: 5.65 ± 0.20 MPa) while maintaining optimal porosity (63.7 ± 1.2%). In vitro, Ta⁵⁺ formed a passivation layer regulating Ca2⁺ release (degradation rate: 5.96% at 28 days and 9.8% for pure β-TCP), while Zn2⁺ enriched PO4 3- ions to accelerate biomimetic mineralization. The co-doped ceramic significantly upregulates osteogenic genes (Runx2: ↑180%, BMP2: ↑230%, OCN: ↑190%) in rat bone marrow mesenchymal stem cells (rBMSCs. In a rat calvarial critical-sized defect model, micro-CT and histology revealed superior bone regeneration with Ta/Zn-β-TCP (BV/TV: 45.98% at 12 weeks), outperforming pure β-TCP (22.27%) and commercial Novabone (45S5 bioglass-based) (41.67%). The material's triple synergy mechanical reinforcement, immunomodulation, and coupled angiogenesis-osteogenesis, establishes it as a promising candidate for non-load bearing bone repair.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e03406"},"PeriodicalIF":9.6,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145068710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue. 可注射生物材料和生物支架修复和再生脑组织的转化考虑。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-15 DOI: 10.1002/adhm.202501711

Michel Modo, Alena Kisel

{"title":"Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue.","authors":"Michel Modo, Alena Kisel","doi":"10.1002/adhm.202501711","DOIUrl":"https://doi.org/10.1002/adhm.202501711","url":null,"abstract":"Adult neurogenesis can replace lost neurons through migration and participate in the repair of damaged tissues. Neurogenesis by itself is known to be insufficient to replace lost tissue. Injectable bioscaffolds derived from extracellular matrix (ECM) have shown promise in repairing and regenerating brain tissue. These bioscaffolds need to be considered within their pathological context (e.g. proteases), which contribute to its biodegradation. Biodegradation through peripheral immune cells is required to promote the invasion of brain cells and reconstitute a de novo tissue. In addition to the biomaterial characteristics, a greater focus on translational considerations (e.g., intracerebral delivery) is required to establish a robust pathway to the clinic. Especially advances in developing large animal models will be required to address key issues, such as regrowing of a gyrencephalic brain, as well as potential limitations to tissue regeneration due to the size of the volumetric deficits. It is advocated that non-human primates will be an essential step prior to first-in-human investigations. Injectable bioscaffolds have the potential to promote a paradigm shift in the treatment of acute brain injuries, but this can only be achieved through a robust and potentially iterative translational effort.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e01711"},"PeriodicalIF":9.6,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145068705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0