Advanced Healthcare Materials最新文献

{"title":"Opening Avenues for Rheumatoid Arthritis Treatment via Transdermal Application of Microneedles: Progress so far and Future Outlook","authors":"Kaustubh Ajit Kolekar,&nbsp;Bushra Bashir,&nbsp;Popat S. Kumbhar,&nbsp;Kalpana S. Patil,&nbsp;Gaurav Gupta,&nbsp;Anuradha Acharya,&nbsp;Shailendra S. Gurav,&nbsp;Harish Dureja,&nbsp;Kamal Dua,&nbsp;John Disouza,&nbsp;Sachin Kumar Singh","doi":"10.1002/adhm.71672","DOIUrl":"10.1002/adhm.71672","url":null,"abstract":"<div>\u0000 \u0000 <p>Rheumatoid arthritis (RA) is a chronic autoimmune disease with a global prevalence of 0.5% to 2%, causing serious impairment and early mortality. Presently approved therapeutics comprising non-steroidal anti-inflammatory drugs (NSAIDs), disease-modifying anti-rheumatic drugs (DMARDs), corticosteroids, etc. only lower pain, edema, and inflammation. Most of these therapeutics have been administered orally, intravenously, and intra-articularly, minimizing patient adherence. Additionally, high doses of these drugs need to be taken for a long duration and have poor specificity, causing fatal side effects. The conventional and nanocarrier (NCs)-based topical cargo delivery pose challenges like poor residence, possibility of skin reactions, and low patient adherence. Therefore, transdermal delivery of these therapeutics using microneedles (MNs) can be promising to improve permeability, bioavailability, targeting, and patient compliance while minimizing side effects. Moreover, NCs-assisted MNs, biomimetic NCs-based MNs, and MNs for biologics delivery have also emerged as a promising platform for targeting RA efficiently. This review attempts to give an overview on the transdermal drug delivery using MNs and NCs-based MNs in the efficient management of RA. Thus, different MNs and their amalgamation with NCs could effectively deliver and manage RA via the transdermal route.</p>\u0000 </div>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 37","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148899796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Hybrid Cell Membrane-Coated Nanoparticles for Synergizing Sonodynamic Therapy and Immunotherapy against Triple-Negative Breast Cancer\".","authors":"","doi":"10.1002/adhm.71820","DOIUrl":"https://doi.org/10.1002/adhm.71820","url":null,"abstract":"","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71820"},"PeriodicalIF":11.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On-Demand Generation of Patient-Derived Organoids for Precision Oncology: Progress and Prospects.","authors":"Ziliang Guo, Shijie Yang, Keyu Shen, Yumeng Liu, Xiequn Xu","doi":"10.1002/adhm.71817","DOIUrl":"https://doi.org/10.1002/adhm.71817","url":null,"abstract":"<p><p>Precision oncology has become a focus of both clinical practice and basic research. With the rapid evolution of organoid culture techniques and the integration of biomedical engineering approaches, patient-derived organoid (PDO) systems are playing an increasingly pivotal role in precision cancer therapy. By recapitulating patient-specific tumor characteristics, these platforms demonstrate considerable potential for clinical translation. Despite remarkable progress, the impact of PDO models on real-world therapeutic decision-making remains limited. Most existing studies have focused on preclinical concept validations or small-scale trials, leaving a substantial gap before these models can be implemented to guide individualized cancer therapy. This review examines on-demand PDO generation through the selection of sample-processing methods, matrices, and platform architectures matched to specific treatment-response questions. We compare conventional and engineered systems in terms of biological complexity, sample requirements, reported timelines, assay readouts, and clinical evidence. Particular attention is given to engineering trade-offs and the distinction between technical feasibility, clinical response correlation, and demonstrated utility in treatment selection.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71817"},"PeriodicalIF":11.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective Blood Cell Hitchhiking in Whole Blood With Ionic Liquid-Coated PLGA Nanoparticles to Redirect Biodistribution After Intravenous Injection","authors":"Christine M. Hamadani,&nbsp;Duoyi Hu,&nbsp;Gaya S. Dasanayake,&nbsp;Tanveer Shaikh,&nbsp;Gagandeep Singh,&nbsp;Claylee M. Chism,&nbsp;Priyavrat Vashisth,&nbsp;Meghan Gorniak,&nbsp;Wake G. Monroe,&nbsp;George Taylor,&nbsp;Anya Merrell,&nbsp;Emilia Huff,&nbsp;Amber Cecil,&nbsp;Danny Ly,&nbsp;Camille Sperier,&nbsp;Jordan Gill,&nbsp;Mercedes C. Pride,&nbsp;Rebekah Heintz,&nbsp;Karen Wong,&nbsp;Mehjabeen Hossain,&nbsp;Deauntaye Jones,&nbsp;Joy Dhar,&nbsp;Alison Banka,&nbsp;Sara X. Edgecomb,&nbsp;Joh'nis Randall,&nbsp;Donovan S. Darlington,&nbsp;Jaylon Everett,&nbsp;Ethan Jarrett,&nbsp;Thomas A. Werfel,&nbsp;Nicholas C. Fitzkee,&nbsp;Omolola Eniola-Adefeso,&nbsp;Eden E. L. Tanner","doi":"10.1002/adhm.71494","DOIUrl":"10.1002/adhm.71494","url":null,"abstract":"<div>\u0000 \u0000 <p>Nanoparticles (NPs) are great for systemic drug delivery because they can encapsulate diverse therapeutics, protect cargo from degradation, and enable controlled release profiles. Their performance, however, strongly depends on the ability to circulate stably and reach target tissues after administration. Intravenously delivered NPs typically experience rapid opsonization and clearance, resulting in less than 5% delivery to intended tissues. Cellular hitchhiking, in which NPs adsorb onto endogenous blood cells, offers a route to extend circulation and redirect biodistribution, yet existing approaches provide limited control over cell selectivity. This work presents a modular platform in which choline carboxylate ionic liquids (ILs) coat poly(lactic-co-glycolic acid) (PLGA) NPs to engineer selective interactions with defined blood cell populations and promote in situ hitchhiking to lymphocytes, monocytes, granulocytes, platelets, and red blood cells (RBCs). The resulting IL-PLGA NPs display low cytotoxicity, markedly reduced plasma residence, and significantly prolonged circulation in healthy mice after intravenous injection. Distinct IL chemistries produce unique organ-targeting profiles, enabling biodistribution patterns not accessible with unmodified PLGA NPs. The findings demonstrate a tunable IL–nanoparticle interface capable of directing blood cell-specific hitchhiking and establish a generalizable strategy for improving systemic drug delivery through engineered bio–nano interactions.</p>\u0000 </div>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 37","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148682649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silicone Breast Implants as a Model System for Understanding Polymer Permeation in Soft Materials In Vivo","authors":"D. Bouyer,&nbsp;H. Mutlu,&nbsp;C. Charmette,&nbsp;E. Randrianaridera,&nbsp;Z. Adaidi,&nbsp;R. Hedna,&nbsp;L. Pieuchot,&nbsp;I. Pluvy,&nbsp;K. Anselme,&nbsp;N. Couturier,&nbsp;J. P. Mericq,&nbsp;A. Ponche,&nbsp;I. Brigaud","doi":"10.1002/adhm.71641","DOIUrl":"10.1002/adhm.71641","url":null,"abstract":"<p>Silicone breast implants have long been associated with the gradual release of low molecular weight siloxanes from the inner gel through the implant membrane into the periprosthetic biological environment, a phenomenon commonly referred to as “gel bleed.” Despite more than five decades of investigation spanning polymer science, transport theory, and biomedical research, the physicochemical mechanisms underlying silicone permeation remain conceptually fragmented. Here, we revisit silicone permeation by examining how molecular transport arises from the intrinsic interplay between polymer architecture, thermodynamic partitioning, and diffusional mobility within crosslinked networks. We further analyze the key determinants of permeation, including implant aging, barrier-layer technologies, and interaction with the periprosthetic tissue environment. We further discuss how dynamic bio-interfaces influence bidirectional transport and bioaccumulation in vivo. Beyond their implications for implant performance, these observations provide broader conceptual insights into mass transport in soft materials, highlighting general principles relevant to elastomers, hydrogels, and drug-delivery systems. By integrating material structure, transport physics and host interactions, this review establishes a mechanistic viewpoint on polymer permeation in vivo and offers design considerations for next-generation soft implantable biomaterials.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 37","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.71641","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148807915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatiotemporally Controlled Prodrug Release From Light-Triggered Azo-Bond-Cleaved BODIPY Nanoplatform for Trimodal Synergistic Ovarian Cancer Therapy","authors":"Jiaqi Wang,&nbsp;Jie Zhang,&nbsp;Dongping Xu,&nbsp;Yiming Zhang,&nbsp;Xueqing Xia,&nbsp;Shuo Li,&nbsp;Xin-Dong Jiang,&nbsp;Jiangli Fan,&nbsp;Xiaojun Peng,&nbsp;Gaowu Qin","doi":"10.1002/adhm.71656","DOIUrl":"10.1002/adhm.71656","url":null,"abstract":"<div>\u0000 \u0000 <p>Chemotherapy (CT) suffers from poor selectivity and systemic toxicity, while photodynamic therapy (PDT) and photothermal therapy (PTT) are inherently limited by tumor hypoxia and thermoresistance. Herein, we develop a trimodal synergistic nanoplatform (<b>PDM-BDP</b> NPs) for ovarian cancer treatment by integrating PDT, mild PTT (mPTT), and CT into a single azo-bond-linked prodrug system. Upon 808 nm laser irradiation<b>, PDM-BDP</b> NPs generate reactive oxygen species and mild hyperthermia, while simultaneously triggering azo-bond cleavage to release the chemotherapeutic agent phenylenediamine mustard (<b>PDM</b>) and transform into <b>NH₂-BDP</b>, which retains photothermal activity for sustained thermal output. <b>PDM-BDP</b> NPs exhibit efficient cellular uptake, predominant mitochondrial co-localization, and potent photocytotoxicity against A2780 cells with low dark toxicity. Transcriptomics reveals multi-target reprogramming involving proteotoxic stress, DNA damage, and TNF/MAPK activation. Laser-activated <b>PDM-BDP</b> NPs achieve subtotal tumor ablation with excellent biocompatibility. This trimodal synergistic strategy provides a promising approach for precise ovarian cancer therapy.</p>\u0000 </div>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 37","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148823750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Information: Adv. Healthcare Mater. 37/2026","authors":"","doi":"10.1002/adhm.71680","DOIUrl":"https://doi.org/10.1002/adhm.71680","url":null,"abstract":"","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 37","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.71680","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149125722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microfluidic Engineering of Microgels: A Review of Emerging Technologies, Materials, Fabrication Strategies, and Applications.","authors":"Afshin Abrishamkar, Laura Neely, Cynthia Pham, Nada Ibrahim, Alexis Larios-Cervantes, Ben A Kertesz, Todd Hoare","doi":"10.1002/adhm.71809","DOIUrl":"https://doi.org/10.1002/adhm.71809","url":null,"abstract":"<p><p>Microparticles of hydrogels, also known as microgels, have garnered extensive attention due to their versatile properties and wide range of applications in different fields of science, technology, and medicine. Among the developed technologies to produce microgels, the precise control over fluid handling offered by microfluidics enables particular fine-tuning of the shape, size, and composition of microgels. This article provides a review of recent progress in the development of microfluidic technologies for the fabrication of microgels based on different hydrogel-based biomaterials for diverse practical applications. The fundamental principles of different microfluidic-based techniques for microgel formation are summarized including chip-based, capillary-based, valve-based, three-dimensional printed, and digital microfluidics. Following, strategies for producing microgels from various natural and synthetic polymers using a range of potential crosslinking techniques with varying sizes, structures (water-in-oil, oil-in-water, higher order emulsion, and core-shell), and morphologies (spherical, non-spherical, Janus, and porous) are discussed in detail. Subsequently, the practical applications of microgels produced via microfluidic technologies are summarized across various fields including cell encapsulation, tissue engineering, particle removal, sensors, and food and nutrition, with current challenges and opportunities highlighted to motivate future research in the field.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e71809"},"PeriodicalIF":11.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical Detection of Cellular Signals at Material Interfaces","authors":"Xuchen Ren,&nbsp;Jitong Ren,&nbsp;Zixin Zhang,&nbsp;Koney Eungkon Kim,&nbsp;Francis L. Hong,&nbsp;Yuecheng Peter Zhou","doi":"10.1002/adhm.71670","DOIUrl":"10.1002/adhm.71670","url":null,"abstract":"<p>Cellular functions are dynamically regulated by electrical, chemical, and mechanical signals. Optical methods provide high spatial resolution and flexibility for detecting and understanding cellular signals, but most existing approaches rely on fluorescent reporters, which are often limited by photobleaching, phototoxicity, and potential perturbation of native cellular behaviors. In recent years, materials-based optical detection has emerged as a promising strategy, which transduces subtle cellular signals into measurable optical readouts without introducing fluorescent labels or the need for genetic modification. However, this field is still at a nascent stage, as many materials platforms are constrained by limited detection sensitivity, specificity, spatiotemporal resolution, and compatibility with different biological systems. Here, we discuss recent advances in optical methods for detecting cellular signals harnessing cell-material interfaces. In particular, we connect the structure-property relationships of polymers, liquid crystals, carbon-based materials, two-dimensional materials, quantum materials, and plasmonic metals to their optical detection mechanisms. We then summarize the applications of these materials in optical detection of bioelectric, biomechanical, and biochemical signals. We anticipate that this review will bridge materials science with cell biology, and guide the rational design of next-generation material-based optical detection platforms for minimally invasive, high-sensitivity interrogation of cellular signals.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 37","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.71670","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148899771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineered Nanoplatforms Targeting Activated Hepatic Stellate Cells for Liver Fibrosis Therapy via TGF-β Axis Inhibition and Ferroptosis Induction","authors":"Yinuo Yang,&nbsp;Mengyao Mu,&nbsp;Ke Ren,&nbsp;Hui Liu,&nbsp;Pengju Ma,&nbsp;Yingqi Wang,&nbsp;Mengmeng Zhang,&nbsp;Xueli Xu,&nbsp;Wenzhe Li,&nbsp;Wenshuang Gao,&nbsp;Xiao Sun,&nbsp;Qiang Zhu","doi":"10.1002/adhm.71657","DOIUrl":"10.1002/adhm.71657","url":null,"abstract":"<p>Liver fibrosis and its terminal stage, cirrhosis, represent a major cause of morbidity and mortality related to hepatic pathologies. Activated hepatic stellate cells (aHSCs) are the principal drivers of fibrogenesis and therefore constitute key therapeutic targets. Lanifibranor, a pan-peroxisome proliferator-activated receptor agonist, has shown promising antifibrotic efficacy; however, its clinical application is limited by rapid systemic clearance and insufficient accumulation in fibrotic liver tissue. In this study, we report an aHSC-targeted nanoplatform for lanifibranor delivery based on vitamin A-functionalized two-dimensional iron sulfide nanosheets (FeS-V_A@lanifibranor, FVL). Lanifibranor was electrostatically loaded onto vitamin A-modified FeS nanosheets, enabling selective uptake by aHSCs and enhancing hepatic accumulation of lanifibranor. FVL significantly downregulated the expression of key fibrogenic markers and markedly reduced collagen accumulation. Mechanistically, the therapeutic efficacy of FVL arises from a dual-action mechanism: inhibition of SMAD2/3 phosphorylation within the transforming growth factor-β (TGF-β) signaling pathway and induction of ferroptosis in aHSCs. In conclusion, this study provides an effective aHSC-specific nanotherapeutic strategy for liver fibrosis treatment and highlights the translational potential of FVL nanoplatforms for targeted antifibrotic therapy.</p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"15 37","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.71657","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148943897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}