Advanced Healthcare Materials最新文献_第8页

RETRACTION: Decellularized Scaffolds with Double-Layer Aligned Microchannels Induce the Oriented Growth of Bladder Smooth Muscle Cells: Toward Urethral and Ureteral Reconstruction.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-02-05 DOI: 10.1002/adhm.202500499

{"title":"RETRACTION: Decellularized Scaffolds with Double-Layer Aligned Microchannels Induce the Oriented Growth of Bladder Smooth Muscle Cells: Toward Urethral and Ureteral Reconstruction.","authors":"","doi":"10.1002/adhm.202500499","DOIUrl":"https://doi.org/10.1002/adhm.202500499","url":null,"abstract":"Retraction: Q. Cheng, L. Zhang, J. Zhang, X. Zhou, B. Wu, D. Wang, T. Wei, M. Shafiq, S. Li, D. Zhi, Y. Guan, K. Wang, and D. Kong, \"Decellularized Scaffolds with Double-Layer Aligned Microchannels Induce the Oriented Growth of Bladder Smooth Muscle Cells: Toward Urethral and Ureteral Reconstruction,\" Advanced Healthcare Materials 12, no. 26 (2023): 2300544, https://doi.org/10.1002/adhm.202300544. The above article, published online on 28 August 2023 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors; the journal Editor-in-Chief, Uta Goebel; and Wiley-VCH GmbH. The retraction has been agreed upon following an investigation into concerns raised by a third party, which revealed inappropriate duplication of image sections and/or formatting artefacts in Figures 2B, 5A, and 7C, as well as errors in Figure S8 and its quantifications. The authors have stated that these image alterations were performed to enhance the visual appearance of the images and do not impact the clinical and scientific findings outlined in the paper. Nevertheless, due to the number and the level of inconsistencies identified in the published figures, the editors considered the conclusions substantially compromised and decided to retract the article.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2500499"},"PeriodicalIF":10.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kidney Fibrosis In Vitro and In Vivo Models: Path Toward Physiologically Relevant Humanized Models. 肾脏纤维化体外和体内模型：通向生理相关的人源化模型之路。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-02-05 DOI: 10.1002/adhm.202403230

Gabriele Addario, Lorenzo Moroni, Carlos Mota

{"title":"Kidney Fibrosis In Vitro and In Vivo Models: Path Toward Physiologically Relevant Humanized Models.","authors":"Gabriele Addario, Lorenzo Moroni, Carlos Mota","doi":"10.1002/adhm.202403230","DOIUrl":"https://doi.org/10.1002/adhm.202403230","url":null,"abstract":"Chronic kidney disease (CKD) affects over 10% of the global population and is a leading cause of mortality. Kidney fibrosis, a key endpoint of CKD, disrupts nephron tubule anatomy and filtration function, and disease pathomechanisms are not fully understood. Kidney fibrosis is currently investigated with in vivo models, that gradually support the identification of possible mechanisms of fibrosis, but with limited translational research, as they do not fully recapitulate human kidney physiology, metabolism, and molecular pathways. In vitro 2D cell culture models are currently used, as a starting point in disease modeling and pharmacology, however, they lack the 3D kidney architecture complexity and functions. The failure of several therapies and drugs in clinical trials highlights the urgent need for advanced 3D in vitro models. This review discusses the urinary system's anatomy, associated diseases, and diagnostic methods, including biomarker analysis and tissue biopsy. It evaluates 2D and in vivo models, highlighting their limitations. The review explores the state-of-the-art 3D-humanized in vitro models, such as 3D cell aggregates, on-chip models, biofabrication techniques, and hybrid models, which aim to mimic kidney morphogenesis and functions. These advanced models hold promise for translating new therapies and drugs for kidney fibrosis into clinics.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403230"},"PeriodicalIF":10.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glepaglutide-Loaded Foam for the Induction of Mucosal Healing in the Treatment of Inflammatory Bowel Disease. 治疗炎症性肠病时用于诱导黏膜愈合的格列吡嗪载药泡沫

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-02-05 DOI: 10.1002/adhm.202403497

Wunan Zhang, William Van den Bossche, Hafsa Yagoubi, Espoir K Kambale, Khadija Wahni, Tanya Saxena, Léo Guilbaud, Tom G Moreels, Joris Messens, Ana Beloqui

{"title":"Glepaglutide-Loaded Foam for the Induction of Mucosal Healing in the Treatment of Inflammatory Bowel Disease.","authors":"Wunan Zhang, William Van den Bossche, Hafsa Yagoubi, Espoir K Kambale, Khadija Wahni, Tanya Saxena, Léo Guilbaud, Tom G Moreels, Joris Messens, Ana Beloqui","doi":"10.1002/adhm.202403497","DOIUrl":"https://doi.org/10.1002/adhm.202403497","url":null,"abstract":"Glucagon-like peptide 2 (GLP-2) stimulates intestinal growth, repairs mucosa, and enhances epithelial integrity but has a short half-life (7 min). Glepaglutide (GL), a GLP-2 analog with an extended half-life (50 h), is currently undergoing clinical trials for patients with short bowel syndrome. GL requires subcutaneous injection, which poses challenges for potential patient compliance. To address this challenge, GL was loaded into a rectal foam formulation using CO2 as a permeation enhancer to combine both the local and systemic effects of the GLP-2 analog. In a dextran sodium sulfate (DSS)-induced colitis model, the GL-loaded foam (GLF) significantly mitigated the severity of colitis. GLF facilitated mucosal healing, as evidenced by colonoscopy images, increased plasma markers of mucosal healing, and increased crypt depth. To evaluate GL absorption in the colon, fluorescein dextran 4K (FD 4K) was employed. The foam formulation improved macromolecule absorption in the colon, with fast recovery of enhanced permeation that dissipated after 4 h. This study highlights GLF as a promising formulation for GL administration, balancing systemic and local anti-inflammatory effects.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403497"},"PeriodicalIF":10.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cholesterol Functionalized Nanoparticles Are Effective against Helicobacter pylori, the Gastric Bug: A Proof-of-Concept Study.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-02-05 DOI: 10.1002/adhm.202404065

Ana Sofia Pinho, Renato Pereira, Mariana Pereira, Akhilesh Rai, Lino Ferreira, Maria Cristina Lopes Martins, Paula Parreira

{"title":"Cholesterol Functionalized Nanoparticles Are Effective against Helicobacter pylori, the Gastric Bug: A Proof-of-Concept Study.","authors":"Ana Sofia Pinho, Renato Pereira, Mariana Pereira, Akhilesh Rai, Lino Ferreira, Maria Cristina Lopes Martins, Paula Parreira","doi":"10.1002/adhm.202404065","DOIUrl":"https://doi.org/10.1002/adhm.202404065","url":null,"abstract":"Helicobacter pylori chronic infection is the highest risk factor for the development of gastric cancer, being this Gram-negative bacterium classified as carcinogenic. The mounting resistance of H. pylori to antibiotics calls for innovative therapeutic strategies. Here, the proof-of-concept studies that support the development of a \"trojan horse\" therapeutic strategy based on cholesterol-grafted nanoparticles (Chol-NP) to counteract H. pylori infection are depicted. The bacterium ability to specifically recognize and bind to surface grafted cholesterol is demonstrated by its adhesion to cholesterol(Chol)-functionalized self-assembled monolayers (SAMs) on gold substrates (2D Chol-SAMs) in a concentration dependent manner, with optimal Chol-SAMs prepared with 25% Chol-polyethylene glycol (PEG)-thiol in solution (75% tetra(ethylene glycol)-thiol). These results further show that cholesterol functionalized gold nanoparticles (3D Chol-SAMs, Chol-NP) eradicate H. pylori at a minimum bactericidal concentration of 125 µg mL-1. Chol-NP kill H. pylori through internalization and membrane rupture, as observed by transmission electron microscopy (TEM). Chol-NP are cytocompatible (human gastric adenocarcinoma (AGS) cell line), non-hemolytic and innocuous to bacteria representative of the gut microbiota (Escherichia coli and Lactobacillus acidophilus). This study supports the further development of cholesterol functionalized biomaterials as an advanced and targeted treatment for H. pylori infection.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2404065"},"PeriodicalIF":10.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Potential 3-in-1 Combined AntiSARS-CoV-2 Therapy Using Pulmonary MIL-100(Fe) Formulation.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-02-05 DOI: 10.1002/adhm.202403988

Beatrice Fodor, Inés Álvarez-Miguel, Catalina Biglione, Guillermo G López, África González-Fernández, Fabrice Salles, Tania Hidalgo, Patricia Horcajada

{"title":"A Potential 3-in-1 Combined AntiSARS-CoV-2 Therapy Using Pulmonary MIL-100(Fe) Formulation.","authors":"Beatrice Fodor, Inés Álvarez-Miguel, Catalina Biglione, Guillermo G López, África González-Fernández, Fabrice Salles, Tania Hidalgo, Patricia Horcajada","doi":"10.1002/adhm.202403988","DOIUrl":"https://doi.org/10.1002/adhm.202403988","url":null,"abstract":"The emergence and rapid propagation of infectious diseases, including the COVID-19 pandemic, has evidenced the vulnerabilities in global health surveillance, the ease of transmission, and the imperative need for effective treatments. In this context, nanomedicines based on metal-organic frameworks (MOFs) have garnered great relevance as promising drug delivery platforms in a large range of complex diseases (e.g., cancer, and infections). However, most research has focused on sensing with scarce examples in antiviral therapies. Hence, here a pioneer combined 3-in-1 effect anti-COVID pulmonary multitherapy based on the mesoporous iron(III) carboxylate MIL-100(Fe) nanoparticles is proposed, with the proven intrinsic MOF effect, associated with favipiravir drug into their porosity and heparin on their external surface. A significant antiviral effect against a real scenario of COVID-19 infection is demonstrated (≈70% inhibition), ensuring a suitable cellular viability. Further, a convenient pulmonary formulation is prepared based on mannitol-based microspheres, testing its safety and biodistribution in healthy mice. No significant side effects are observed, reaching successfully the deep lungs, emphasizing a reduced immunological response compared to their controls. Therefore, these promising results open new horizons for future (pre)clinical trials targeting challenging infectious/pulmonary pathologies, enhancing the feasibility of designing customized therapeutic MOF platforms.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403988"},"PeriodicalIF":10.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Next-Generation Oral Ulcer Management: Integrating Cold Atmospheric Plasma (CAP) with Nanogel-Based Pharmaceuticals for Inflammation Regulation.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-02-03 DOI: 10.1002/adhm.202403223

Yanfen Zheng, Ziqi Zhuang, Renwu Zhou, Luo Zheng, Changhong Li, Rusen Zhou, Yuting Gao, Liang Zhang, Yating Zheng, Liqian Zhao, Syed Faheem Askari Rizvi, Bocheng Yang, Lili Jiang, Jinyong Lin, Anqi Wang, Wei Zhou, Hongwei Cheng, Dong Li, Chengchao Chu, Erik W Thompson, Yunlong Wu, Gang Liu, Yun Zeng, Peiyu Wang

{"title":"Next-Generation Oral Ulcer Management: Integrating Cold Atmospheric Plasma (CAP) with Nanogel-Based Pharmaceuticals for Inflammation Regulation.","authors":"Yanfen Zheng, Ziqi Zhuang, Renwu Zhou, Luo Zheng, Changhong Li, Rusen Zhou, Yuting Gao, Liang Zhang, Yating Zheng, Liqian Zhao, Syed Faheem Askari Rizvi, Bocheng Yang, Lili Jiang, Jinyong Lin, Anqi Wang, Wei Zhou, Hongwei Cheng, Dong Li, Chengchao Chu, Erik W Thompson, Yunlong Wu, Gang Liu, Yun Zeng, Peiyu Wang","doi":"10.1002/adhm.202403223","DOIUrl":"https://doi.org/10.1002/adhm.202403223","url":null,"abstract":"Oral ulcers, affecting 27.9% of adults, can lead to malnutrition and dehydration, especially in individuals with diabetes, cancer, viral infections, and autoimmune diseases. Existing treatments-including oral films, sprays, frosts, and powders-often fail to be effective due to rapid dilution and clearance in the moist oral environment. This study is the first to investigate the use of Cold Atmospheric Plasma (CAP) for treating oral ulcers and its underlying molecular mechanisms. A novel high-bioavailability, mucoadhesive therapy combining handheld three dimensions (3D) multi-microhole CAP is developed with a nanogel-based pharmaceutical system containing glucose oxidase (GOx) and catalase (CAT), termed GCN. These results showed that both CAP alone and CAP combined with GCN significantly accelerate oral ulcer healing, modulate immune responses, and activate the Epidermal Growth Factor Receptor (EGFR) in acetic acid-induced oral ulcers, outperforming untreated controls and the conventional medication, Watermelon Frost (WF). Furthermore, the CAP+GCN combination enhances therapeutic effects by promoting fibroblast generation. CAP pretreatment also enhances cell permeability and nanoparticle uptake, improving tissue adhesion. These findings are validated in primary Human Gingival Fibroblasts (HGF) and Human Periodontal Ligament Stem Cells (PDLSC) from healthy donors, as well as an oral ulcer model in rats, demonstrating superior biocompatibility and safety.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403223"},"PeriodicalIF":10.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced Antigen Capture via Cholinephosphate-Mediated Cell Membrane Interactions to Improve In Situ Tumor Vaccines.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-02-03 DOI: 10.1002/adhm.202403460

Ting Song, Xin Cui, Jiansheng Lin, Zonghua Liu, Linghong Huang, Wei Xue

{"title":"Enhanced Antigen Capture via Cholinephosphate-Mediated Cell Membrane Interactions to Improve In Situ Tumor Vaccines.","authors":"Ting Song, Xin Cui, Jiansheng Lin, Zonghua Liu, Linghong Huang, Wei Xue","doi":"10.1002/adhm.202403460","DOIUrl":"https://doi.org/10.1002/adhm.202403460","url":null,"abstract":"Inadequate antigen capture and insufficient antigen-presenting cell (APC) activity at tumor sites limit the effectiveness of in situ vaccines. To address this, poly(glutamic acid-cholinephosphate) (pGluCP) is introduced as a polymer with cell membrane adhesion properties capable of capturing both water-soluble and insoluble membrane antigens from necrotic tumor cells while recruiting more APCs. The approach uses manganese-mineralized black phosphorus (MnBP) coated with pGluCP and αPD-1 antibodies to create the MnBP@pGluCP-αPD-1 complex for in situ vaccines. MnBP eradicates tumor cells via photothermal effects, releasing antigens, while Mn2⁺ ions activate the intracellular STING pathway, acting as an adjuvant. pGluCP captures these antigens, forming pathogen-mimicking micro-nanoparticles, leading to an in situ vaccine (MnBP@pGluCP/antigens) that co-localizes antigens and adjuvants. The αPD-1 antibody alleviates tumor-induced immune suppression, enhancing tumor cell-specific killing. This study demonstrates the potential of leveraging cholinephosphate-cell membrane interactions to improve antigen presentation efficiency, significantly bolstering the efficacy of in situ tumor vaccines and opening new avenues for advanced cancer immunotherapy.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403460"},"PeriodicalIF":10.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photothermal-Driven α-Amylase-Modified Polydopamine Pot-Like Nanomotors for Enhancing Penetration and Elimination of Drug-Resistant Biofilms.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-02-03 DOI: 10.1002/adhm.202403033

Xiangxiang Zhai, Yi Liu, Xiaomeng Hao, Ming Luo, Zhixue Gao, Jinmei Wu, Zili Yang, Ying Gan, Suling Zhao, Zhiyong Song, Jianguo Guan

{"title":"Photothermal-Driven α-Amylase-Modified Polydopamine Pot-Like Nanomotors for Enhancing Penetration and Elimination of Drug-Resistant Biofilms.","authors":"Xiangxiang Zhai, Yi Liu, Xiaomeng Hao, Ming Luo, Zhixue Gao, Jinmei Wu, Zili Yang, Ying Gan, Suling Zhao, Zhiyong Song, Jianguo Guan","doi":"10.1002/adhm.202403033","DOIUrl":"https://doi.org/10.1002/adhm.202403033","url":null,"abstract":"Biological enzyme-functionalized antibacterial nanoparticles, which can degrade biofilm and kill bacteria under mild reaction conditions, have attracted much attention for the elimination of deep-seated bacterial infections. However, the poor diffusion and penetration capabilities of recently developed biological enzyme-functionalized antibacterial nanoparticles in biofilm severely impair the eradication efficacy of deep-seated bacteria. Herein, a photothermal-driven nanomotor (denoted as APPNM) is developed for enhancing the elimination of drug-resistant biofilms and the eradication of deep-seated bacteria. The nanomotor contained a pot-like polydopamine (PDA) nanostructure and its outer surface is chemically immobilized with a layer of α-amylases. Under exposure to 808 nm near-infrared (NIR) laser irradiation, the self-propelled nanomotors, integrating the α-amylases to destroy the compact structure of biofilms, can penetrate deeply into biofilms and effectively eliminate them. Subsequently, they can accumulate on the surface of bacteria using the inherent bio-adhesion property of PDA, thereby completely eradicating deep-seated bacteria by photothermal effect. These synergistic effects enable them to exhibit superior antibiofilm effects and produce remarkable therapeutic efficacy with accelerated wound healing in vivo. With excellent biocompatibility, the as-developed nanomotors have great potential to be applied for treating biofilm-related infections.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403033"},"PeriodicalIF":10.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biosensors and Biomarkers for the Detection of Motion Sickness.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-02-03 DOI: 10.1002/adhm.202403606

Yanbing Wang, Chen Liu, Wenjie Zhao, Qingfeng Wang, Xu Sun, Sheng Zhang

{"title":"Biosensors and Biomarkers for the Detection of Motion Sickness.","authors":"Yanbing Wang, Chen Liu, Wenjie Zhao, Qingfeng Wang, Xu Sun, Sheng Zhang","doi":"10.1002/adhm.202403606","DOIUrl":"https://doi.org/10.1002/adhm.202403606","url":null,"abstract":"Motion sickness (MS) is a prevalent syndrome that predominantly occurs during transportation and virtual reality (VR). The absence of reliable indicators and detection methods makes precise diagnosis difficult. Biomarker concentrations and trends may imply individual susceptibility, symptom classification, and the specific progression of MS. It is therefore essential to explore biosensors capable of providing sensitive, accurate, and real-time monitoring of biomarkers. This review provides a summary of the pathogenesis and biological pathways underlying MS, followed by an examination of biomarkers and their research progress. The most recent electrochemical biosensors developed for the non-invasive detection of representative biomarkers (e.g., cortisol, α-amylase, and estrogen) are comprehensively summarized. The effectiveness of these biosensors in practical application is discussed. It is anticipated that electrochemical biosensors can be gradually improved from the sampling methods, multimodal combinations, and data processing, which can facilitate the detection of MS toward individuation, refinement, and intelligence.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403606"},"PeriodicalIF":10.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and Cellular Mechanism of Biomimetic Marine Adhesive Protein-Based Coating Against Skin Photoaging.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-02-03 DOI: 10.1002/adhm.202402019

Bo Xue

{"title":"Efficacy and Cellular Mechanism of Biomimetic Marine Adhesive Protein-Based Coating Against Skin Photoaging.","authors":"Bo Xue","doi":"10.1002/adhm.202402019","DOIUrl":"https://doi.org/10.1002/adhm.202402019","url":null,"abstract":"Skin photoaging is a problem worldwide, clinically often accompanied by collagen decline, increased wrinkles, loss of skin elasticity, structurally weakened skin, and other complications, which urgently demand effective treatment strategies. The biosafety and efficacy of single-function therapies for repairing skin photoaging are still challenging for clinical medicine today. At present, numerous studies report that the wet adhesive proteins driven from marine organisms play a critical role in the biomedical material field, particularly in aquatic environments. In this study, a natural recombinant protein-based coating from scallop byssal protein is prepared to investigate the efficacy and cellular mechanism in accelerating the repair of UVB-induced photoaging in a mouse model. In vitro experiments demonstrate the safety of the coating and its efficacy in enhancing cell adhesion, spreading, proliferation, and migration. Additionally, the coating effectively scavenges reactive oxygen species, promotes the expression of cell adhesion molecules and anti-apoptotic proteins, and inhibits inflammatory responses. In animal tests, the coating exhibited remarkable adsorption properties, showing significant potential for in situ regenerative therapy, as evidenced by its ability to protect against UVB-induced skin photoaging and oxidative stress. These findings suggest that Sbp9Δ coating provides a simple, safe, and innovative strategy for treating skin photoaging.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2402019"},"PeriodicalIF":10.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0