Advanced Healthcare Materials最新文献_第7页

Emerging Applications and Challenges in SPR-Based Biosensors for Non-Invasive Quality Assessment of Wharton's Jelly-Derived Mesenchymal Stem Cells (WJ-MSCs) via Secretome Analysis. 基于spr的生物传感器在沃顿果冻源间充质干细胞（WJ-MSCs）无创质量评估中的应用和挑战

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-10-07 DOI: 10.1002/adhm.202502045

Abilashinee Govindasamy, Wan Safwani Wan Kamarul Zaman, Salmah Karman, Sharifah Norsyahindah Syed Nor, Rozalina Zakaria

{"title":"Emerging Applications and Challenges in SPR-Based Biosensors for Non-Invasive Quality Assessment of Wharton's Jelly-Derived Mesenchymal Stem Cells (WJ-MSCs) via Secretome Analysis.","authors":"Abilashinee Govindasamy, Wan Safwani Wan Kamarul Zaman, Salmah Karman, Sharifah Norsyahindah Syed Nor, Rozalina Zakaria","doi":"10.1002/adhm.202502045","DOIUrl":"https://doi.org/10.1002/adhm.202502045","url":null,"abstract":"Mesenchymal stem cells (MSCs) have gained widespread attention for their regenerative and immunomodulatory potential, primarily mediated through their secretome. Among various MSC sources, Wharton's Jelly-derived MSCs (WJ-MSCs) are emerging as a promising candidate due to their superior proliferative capacity and ethical advantages. However, a critical challenge in stem cell-based therapies is the need for robust, non-invasive quality assessment methods to ensure biosafety and bioefficacy. Traditional evaluation techniques, such as enzyme-linked immunosorbent assay (ELISA) and liquid chromatography-mass spectrometry (LC-MS), offer limited real-time detection and require complex sample processing. Surface Plasmon Resonance (SPR) biosensors provide a real-time, label-free alternative for assessing MSC secretomes, particularly the quantification of key bioactive molecules such as hepatocyte growth factor (HGF) and c (VEGF). This review explores the design, application, and challenges of SPR-based biosensing for secretome analysis in WJ-MSC quality assessment. The principles of SPR, key biosensor design parameters, and the role of HGF and VEGF are also discussed as critical biomarkers in evaluating the therapeutic potential of WJ-MSCs. Future research should focus on optimizing ligand immobilization strategies, improving sensitivity for low-concentration secretomes, and aligning SPR-based assessments with regulatory guidelines to facilitate its adoption in regenerative medicine.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e02045"},"PeriodicalIF":9.6,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145237499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulating Smart All-in-One Chitosan Hydrogel for High Performance Wound Dressing. 制定智能一体化壳聚糖水凝胶用于高性能伤口敷料。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-10-06 DOI: 10.1002/adhm.202502971

Chia-Chi Lin, Andi Magattang Gafur Muchlis, Ren-Jei Chung, Ssu Yu Huang, Michal Martinka, Syang-Peng Rwei, Aivaras Kareiva, Jen-Chang Yang, Chun Che Lin

{"title":"Formulating Smart All-in-One Chitosan Hydrogel for High Performance Wound Dressing.","authors":"Chia-Chi Lin, Andi Magattang Gafur Muchlis, Ren-Jei Chung, Ssu Yu Huang, Michal Martinka, Syang-Peng Rwei, Aivaras Kareiva, Jen-Chang Yang, Chun Che Lin","doi":"10.1002/adhm.202502971","DOIUrl":"https://doi.org/10.1002/adhm.202502971","url":null,"abstract":"The poor mechanical and film formation properties of chitosan hydrogel limit its application as a wound dressing. To solve this shortcoming, chitosan-graft-poly(N-isopropyl acrylamide) (PNIPAAm) and crosslinked with polyvinyl alcohol/polyvinyl pyrollidone (PVA/PVP) blend polymer is designed to form the thermosensitive hydrogel. After that, silver nanoparticles (AgNPs), synthesized by the co-reduction method, are added into the chitosan hydrogel network to provide better antibacterial ability. When the temperature is above 32 °C, the hydrogel showed a decrease in particle size and transmittance, which proved that it is a thermal responsive material. Chitosan hydrogels are evaluated for their thermal properties, mechanical properties, swelling effects, antibacterial properties, and wound healing ability in rats. The results show that the hydrogel has a large number of intermolecular and intramolecular hydrogen bonds and a porous 3D network structure. The swelling ratio is 358.86 ± 23.56% and the degradation ratio is 86.02 ± 2.82% at 21 days. It also has excellent antibacterial properties against Escherichia coli and a much faster wound recovery ability. Therefore, a chitosan hydrogel with excellent physical properties is formulated in this study and has great potential as a smart all-in-one wound dressing for accelerating wound healing.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e02971"},"PeriodicalIF":9.6,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145237432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermodynamic Delivery of Trehalose into Extracellular Vesicles for Enhanced Lyophilization. 海藻糖进入细胞外囊泡的热力学传递以增强冻干。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-10-06 DOI: 10.1002/adhm.202500522

Tian Wang, Ying Fu, Bangrui Yu, Wenjun Dang, Min Ji, Zhe Jian, Jian Ding, Guangjian Zhang, Haishui Huang

{"title":"Thermodynamic Delivery of Trehalose into Extracellular Vesicles for Enhanced Lyophilization.","authors":"Tian Wang, Ying Fu, Bangrui Yu, Wenjun Dang, Min Ji, Zhe Jian, Jian Ding, Guangjian Zhang, Haishui Huang","doi":"10.1002/adhm.202500522","DOIUrl":"https://doi.org/10.1002/adhm.202500522","url":null,"abstract":"Extracellular vesicles (EVs) hold great potential as therapeutic agents and drug carriers. Conventionally, EVs are cryopreserved at ultra-low temperatures, with substantial cryoinjury associated with the freeze/thaw cycle. Lyophilization has emerged as a promising alternative approach; however, suboptimal outcomes remain owing to the challenge of lyoprotectant delivery into EVs. Here, the atypical transport property of the EV membrane is unraveled, and lyoprotective trehalose is delivered into EVs by combining substantial hypotonicity (below intravesicular colloid osmolality) and mild heat shock (42 °C). Consequently, the lyophilization of trehalose-laden EVs is notably enhanced, with less EV loss, more RNA and protein retention, and superior therapeutic efficacy. Moreover, the EVs can be co-reconstituted and co-lyophilized with hyaluronic and methylcellulose (HAMC) hydrogel carriers, yielding excellent preservation outcomes and controlled EV release. Lyophilized EVs or HAMC-EVs maintain Treg cell regulation in vitro and experimental autoimmune encephalomyelitis disease treatment in vivo. Overall, not only are EVs and EV-hydrogel constructs efficiently lyophilized for widespread application, but a thermodynamic approach is also developed to safely and uniformly deliver various hydrophilic molecules into EVs.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e00522"},"PeriodicalIF":9.6,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photothermally Activated Pyroelectric Enhanced Self-Powered Wound Dressing: Breaking Through the Limitations of Interfacial Impedance to Achieve Efficient Electrical Stimulation for Wound Repair. 光热激活热释电增强自供电伤口敷料：突破界面阻抗限制，实现有效的伤口修复电刺激。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-10-06 DOI: 10.1002/adhm.202503405

Yani Sun, Yufei Tang, Cuihong Sheng, Bo Zhang, Hao Zhang, Wanxing Zheng, Zhangwen Xie, Yuming Zhang, Lei Chen, Kang Zhao, Zixiang Wu

{"title":"Photothermally Activated Pyroelectric Enhanced Self-Powered Wound Dressing: Breaking Through the Limitations of Interfacial Impedance to Achieve Efficient Electrical Stimulation for Wound Repair.","authors":"Yani Sun, Yufei Tang, Cuihong Sheng, Bo Zhang, Hao Zhang, Wanxing Zheng, Zhangwen Xie, Yuming Zhang, Lei Chen, Kang Zhao, Zixiang Wu","doi":"10.1002/adhm.202503405","DOIUrl":"https://doi.org/10.1002/adhm.202503405","url":null,"abstract":"The mismatch between interfacial impedance at the hydrogel-electrical stimulation layer interface in conventional double-layer self-adhesive electrical stimulation wound dressings remains a critical challenge, limiting charge transfer efficiency, and therapeutic outcomes. Herein, this study introduces a photothermally activated pyroelectric-enhanced self-powered wound dressing designed to overcome this limitation through a synergistic tri-modal mechanism integrating photothermal, pyroelectric, and piezoelectric effects. The wound dressing comprises a dual-layer architecture: an outer layer of hydrophobic poly(vinylidene fluoride) (PVDF)/cotton-based electrostimulation film and an inner hydrophilic self-adhesive hydrogel layer. Upon NIR irradiation, the hydrogel layer undergoes localized photothermal heating, dynamically reducing interfacial impedance (≈10× increase in conductivity) and facilitating efficient charge migration across the interface. Concurrently, the NIR-induced photothermal effect activates pyroelectric polarization in the PVDF layer, which synergistically couples with piezoelectric output to generate an enhanced endogenous electric field (≈1.5× the electric field of piezoelectric-only effects). In vitro and in vivo studies showed that this dressing significantly promoted wound healing. Compared with the control group (on the 7th day), the inflammatory chemokine density reduced by 99.36×, the capillary density increased by 3.85×, resulting in a 2.59× enhancement in the wound healing rate. Consequently, the photothermally activated pyroelectric-enhanced self-powered wound dressing presents a highly sophisticated and effective therapeutic approach for accelerating wound healing.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e03405"},"PeriodicalIF":9.6,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ROS-Triggered Microgels for Programmable Drug Release in Volumetric Muscle Loss Repair. ros触发微凝胶在体积肌肉损失修复中的可编程药物释放。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-10-06 DOI: 10.1002/adhm.202502203

Seungjun Lee, Goeun Choe, Junghyun Kim, Junggeon Park, Jia Yi Erica Kok, Jae Young Lee

{"title":"ROS-Triggered Microgels for Programmable Drug Release in Volumetric Muscle Loss Repair.","authors":"Seungjun Lee, Goeun Choe, Junghyun Kim, Junggeon Park, Jia Yi Erica Kok, Jae Young Lee","doi":"10.1002/adhm.202502203","DOIUrl":"https://doi.org/10.1002/adhm.202502203","url":null,"abstract":"Volumetric muscle loss (VML), frequently resulting from traumatic or surgical damage, causes significant muscle mass depletion and fibrosis, and presents major challenges to effective regeneration. In this study, reduced graphene-containing hyaluronic acid microgels (rGHMs) are developed as a multifunctional platform for reactive oxygen species (ROS)-scavenging and ROS-responsive drug delivery to treat VML. The rGHMs are synthesized via a water-in-oil emulsion and subsequent chemical reduction. rGHMs demonstrate superior antioxidative capability, curcumin loading efficiency, and ROS-mediated drug release properties compared to HA microgels (HMs) and unreduced graphene-oxide containing HA microgels (GHMs). In particular, curcumin-loaded rGHMs (Cur/rGHMs) significantly facilitate curcumin release with a 2.6-fold increase under 1 mm H2O2 compared to non-ROS conditions, demonstrating programmable, ROS-triggered release kinetics. In vitro studies confirm that rGHMs are cytocompatible and protect C2C12 myoblasts from ROS-induced damage. In vivo studies using a mouse VML model reveal that Cur/rGHMs significantly enhance skeletal muscle regeneration, as evidenced by an increased number of centronucleated muscle cells, 89.0 % muscle strength recovery, 51.0 % reduction in fibrosis, a 2.3-fold increase in vascularization, and attenuated inflammatory macrophage infiltration. These ROS-responsive microgels enable programmed curcumin delivery in oxidative environments, offering a promising therapeutic strategy for skeletal muscle regeneration in VML.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e02203"},"PeriodicalIF":9.6,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "The Past, Present, and Future of Tubular Melt Electrowritten Constructs to Mimic Small Diameter Blood Vessels - A Stable Process?" 纠正“管状熔体电写结构模拟小直径血管的过去、现在和未来——一个稳定的过程？”

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-10-05 DOI: 10.1002/adhm.202504248

引用次数: 0

Organ-Targeted and Organelle-Targeted Liposome Gene Vector Construction. 器官靶向和细胞器靶向脂质体基因载体的构建。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-10-05 DOI: 10.1002/adhm.202502254

Qi Wang, Sikun Xiong, Ranbo Zhao, Junxi Chen, Sixuan Li, Wei Jiang, Ling Zhang

{"title":"Organ-Targeted and Organelle-Targeted Liposome Gene Vector Construction.","authors":"Qi Wang, Sikun Xiong, Ranbo Zhao, Junxi Chen, Sixuan Li, Wei Jiang, Ling Zhang","doi":"10.1002/adhm.202502254","DOIUrl":"https://doi.org/10.1002/adhm.202502254","url":null,"abstract":"The objective of this study is to systematically evaluate the advantages and disadvantages of liposomes as gene delivery agents, highlighting the importance of targeting in improving the efficiency and specificity of gene delivery. Systematic examination of these factors results in a robust theoretical underpinning and practical directives for the development of high-performance liposome vectors designed for targeted organ and organelle delivery. The research findings are poised to substantially bolster the evolution and practical deployment of gene therapy across various disease treatments. The research findings are poised to substantially bolster the evolution and practical deployment of gene therapy across various disease treatments. Comprehensive details on the production methods and regulatory aspects of targeted liposomes are presented, covering major organs like the liver, kidney, spleen, and lung, as well as pivotal organelles such as the nucleus, mitochondria, and lysosome. To target liposomes precisely, surface modification, composition and structure optimization, and physical variable control are utilized. The method demonstrates considerable therapeutic efficacy in gene editing, metabolic disorder treatment, and lysosomal storage disease management. Innovative strategies for optimizing liposome delivery systems are delineated in this study, emphasizing their revolutionary role in gene therapy.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e02254"},"PeriodicalIF":9.6,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Engineered Cartilage Composition and Function Using Raman Spectroscopy. 利用拉曼光谱评价工程软骨的组成和功能。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-10-05 DOI: 10.1002/adhm.202500552

Dev R Mehrotra, Carolina V Cordova, Tianbai Wang, Erik E Ersland, Juncheng Zhang, Steven J Staffa, Thomas P Schaer, Mark W Grinstaff, Brian D Snyder, Mads S Bergholt, Michael B Albro

{"title":"Evaluation of Engineered Cartilage Composition and Function Using Raman Spectroscopy.","authors":"Dev R Mehrotra, Carolina V Cordova, Tianbai Wang, Erik E Ersland, Juncheng Zhang, Steven J Staffa, Thomas P Schaer, Mark W Grinstaff, Brian D Snyder, Mads S Bergholt, Michael B Albro","doi":"10.1002/adhm.202500552","DOIUrl":"https://doi.org/10.1002/adhm.202500552","url":null,"abstract":"A Raman spectroscopy-based platform has tremendous potential to non-destructively monitor the evolving composition of tissue-engineered cartilage (TEC) responsible for its mechanical properties from in vitro cultivation to post-implantation in vivo function. Raman spectroscopy, an inelastic light scattering technique, reflects the biochemical building blocks (amides, sulfates, and hydroxyls) comprising a tissue. Here, an arthroscopy-compatible probe acquires Raman spectra, and a multivariate linear decomposition routine extracts the regression coefficient biomarkers that reflect the contribution of extracellular matrix (ECM) constituents (sulfated glycosaminoglycans [sGAG], collagen, water) and the scaffold biomaterial to the tissue spectra. Repeated Raman acquisitions during cultivation do not alter growth of chondrocyte-seeded-agarose constructs. The Raman-derived ECM biomarkers portray the composition of the evolving neocartilage developed on agarose, hyaluronan, collagen, and polyethylene-glycol scaffolds, accounting for 90%, 78%, and 87% of content variation in sGAG, collagen, and water, and 94% of the variation in stiffness. The ECM biomarkers reveal variability in sGAG and collagen content for constructs infused with donor chondrocytes from a 58-year-old/female, a 36-year-old/male, and a 53-year-old/male, accounting for 81% and 87% of the variation in stiffness and sGAG content. This Raman platform offers a transformative approach enabling optimization of construct fabrication, improving preclinical evaluation, and advancing cartilage regenerative therapies.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e00552"},"PeriodicalIF":9.6,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multivalent Protein Nanorings for Broad and Potent SARS-CoV-2 Neutralization. 广泛和有效中和SARS-CoV-2的多价蛋白纳米结构

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-10-05 DOI: 10.1002/adhm.202503487

Molood Behbahanipour, Carla Goldin, Cecilia Arahi Prato, Ana Luz Paletta, Oriol Bárcenas, Susanna Navarro, Jordi Pujols, Daniel H Murgida, María Virginia Tribulatti, Sebastián Esperante, Damian Alvarez-Paggi, Salvador Ventura

{"title":"Multivalent Protein Nanorings for Broad and Potent SARS-CoV-2 Neutralization.","authors":"Molood Behbahanipour, Carla Goldin, Cecilia Arahi Prato, Ana Luz Paletta, Oriol Bárcenas, Susanna Navarro, Jordi Pujols, Daniel H Murgida, María Virginia Tribulatti, Sebastián Esperante, Damian Alvarez-Paggi, Salvador Ventura","doi":"10.1002/adhm.202503487","DOIUrl":"https://doi.org/10.1002/adhm.202503487","url":null,"abstract":"The ongoing threat of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the limitations of conventional antibody-based therapeutics (ABTs) underscore the need for scalable and customizable antiviral platforms. A modular, protein-only nanoscaffold based on recombinant ring-like particles (RLPs) derived from a viral nucleoprotein (NP), engineered is presented to display high-affinity, de novo-designed minibinders (LCB1 and LCB3) targeting SARS-CoV-2 Spike (S)protein. These binders are site-specifically fused to either the N- or C-termini, or both ends of NP to ensure functional orientation and dense, multivalent display. The resulting constructs self-assemble into stable, biocompatible, and homogeneous nanoparticles that potently inhibit S-angiotensin-converting enzyme 2 receptor (ACE2r) interactions, neutralizing both pseudotyped viral-like particles and authentic SARS-CoV-2, including Omicron BA.5. The dual-display nanoparticle (RLP-1,3), presenting 10 LCB1 and 10 LCB3 domains, exhibit synergistic binding activity, with fM Half Maximal Inhibitory Concentration(IC50) values, outperforming benchmark monoclonal antibodies and clinically approved hyperimmune therapies. Additionally, RLP-1,3 is adapted for diagnostics in an ELISA platform, achieving a Spike protein detection limit of 9 ng mL-1, surpassing commercial assays. This work demonstrates how the convergence of AI-guided binder design and structure-based nanoscaffolding enables next-generation multifunctional bio-nanomaterials. The RLP-minibinder system offers a generalizable, scalable, and cost-efficient plug-and-(dis)play solution with integrated therapeutic and diagnostic capabilities, positioning it as a flexible alternative to ABTs for pandemic preparedness.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e03487"},"PeriodicalIF":9.6,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Challenges in Hemostasis and Advances in Particle-Assisted Styptic Devices. 当前止血的挑战和颗粒辅助止血装置的进展。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-10-05 DOI: 10.1002/adhm.202502600

Daniele Baiocco, Zhibing Zhang, Neil M Eisenstein, Nigel Tai, Liam M Grover

引用次数: 0