Advanced Healthcare Materials最新文献_第7页

CCR2-Engineered Macrophage Membrane-Coated Metal-Polyphenol Nanozyme to Enhance Antioxidation Activity for Inhibiting the Atherosclerotic Progression. ccr2工程巨噬细胞膜包被金属多酚纳米酶增强抗氧化活性抑制动脉粥样硬化进展。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-20 DOI: 10.1002/adhm.202502151

Meng Yan, Yuan Zhong, Sheng Ni, Shirong Zhang, Yingying Jiang, Li Zhu, Kun Zhang, Kaiyong Cai, Kai Qu, Chuanwei Li, Wei Wu

引用次数: 0

A Novel Core-Shell Hydrogel 3D Model for Studying Macrophage Mechanosensing and Foreign Body Giant Cell Formation. 研究巨噬细胞机械传感和异物巨细胞形成的新型核-壳水凝胶三维模型。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-20 DOI: 10.1002/adhm.202501614

Manisha Mahanty, Wenquan Ou, Xiaoping Zhu, Jonathan S Bromberg, Xiaoming He, Shaik O Rahaman

{"title":"A Novel Core-Shell Hydrogel 3D Model for Studying Macrophage Mechanosensing and Foreign Body Giant Cell Formation.","authors":"Manisha Mahanty, Wenquan Ou, Xiaoping Zhu, Jonathan S Bromberg, Xiaoming He, Shaik O Rahaman","doi":"10.1002/adhm.202501614","DOIUrl":"https://doi.org/10.1002/adhm.202501614","url":null,"abstract":"The foreign body response (FBR) to biomaterials is primarily driven by macrophages. At implant sites, macrophages often fuse into destructive foreign body giant cells (FBGCs), yet FBGC-targeted treatments for FBR remain elusive. To fill this knowledge gap, a novel microscale core-shell hydrogel 3D model is developed using heterogeneous alginate-collagen microcapsules with varying matrix stiffness to culture macrophages. This 3D model more closely replicates in vivo conditions. This model is further used to investigate the effects of stiffness and TRPV4 (transient receptor potential vanilloid 4) on FBGC formation. Stiffer 3D hydrogel robustly enhances FBGC formation and F-actin production in wild-type macrophages compared to softer hydrogel, with IL4 and GMCSF priming amplifying these effects. Crucially, TRPV4-null macrophages exhibit reduced FBGC formation and F-actin production, underscoring TRPV4's role in mechanosensing. Further, the N-terminal residues 1-130 of TRPV4 are identified as critical for FBGC formation and F-actin generation. RNA-seq data reveal that TRPV4 modulates inflammatory, fibrotic, and mechanosensitive gene expression in macrophages in 3D environments, offering insights into how TRPV4 governs FBR. Overall, the data establish this 3D model as a powerful tool for biomaterials research and highlight TRPV4 as a key player in macrophage mechanosensing and FBGC formation in 3D condition.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e01614"},"PeriodicalIF":9.6,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145090854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomimetic Anisotropic Polyvinyl Alcohol/Sodium Alginate/MXene Aerogel for Efficient Uremic Toxin Adsorption in Hemoperfusion. 仿生各向异性聚乙烯醇/海藻酸钠/MXene气凝胶在血液灌流中高效吸附尿毒症毒素

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-20 DOI: 10.1002/adhm.202502056

Liqin Wu, Xi Luo, Pengpeng Yue, Kalibinuer Yasen, Zibiao Zhong, Shuangquan Wu, Qifa Ye

{"title":"Biomimetic Anisotropic Polyvinyl Alcohol/Sodium Alginate/MXene Aerogel for Efficient Uremic Toxin Adsorption in Hemoperfusion.","authors":"Liqin Wu, Xi Luo, Pengpeng Yue, Kalibinuer Yasen, Zibiao Zhong, Shuangquan Wu, Qifa Ye","doi":"10.1002/adhm.202502056","DOIUrl":"https://doi.org/10.1002/adhm.202502056","url":null,"abstract":"The accumulation of uremic toxins, which ultimately leads to renal failure, results in systemic complications and necessitates efficient and biocompatible removal strategies. This paper presents the preparation of a biomimetic anisotropic aerogel composed of polyvinyl alcohol (PVA), sodium alginate (SA), and MXenes (Ti3C2TX) via directional freezing. Inspired by plant vascular bundles, the resulting vertically aligned porous structure enhances the mechanical stability of and mass transfer in the material. The aerogel with its high MXene loading and high surface utilization offers remarkable adsorption capacities for urea (221.77 mg g-1) and creatinine (138.07 mg g-1). In vitro assays confirm the excellent hemo- and cytocompatibility of the aerogel. In a rabbit model of acute ischemic kidney injury, two-hour hemoperfusion with the aerogel significantly lowers the urea (38.67 to 16.17 mmol L-1) and creatinine levels (744.62 to 307.46 µmol L-1) without observable toxicity. The multidimensional biomimetic multipore anisotropic MXene aerogel presented here is a structurally optimized and biologically safe adsorbent for efficient uremic toxin clearance and a promising alternative to conventional hemodialysis.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e02056"},"PeriodicalIF":9.6,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145090865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Targeting of the IRF9/RTN4/RHOA/ROCK Pathway via RVG29-Modified PLGA Nanoparticles and rTMS for Neural and Vascular Regeneration Post-Cerebral Infarction. rvg29修饰的PLGA纳米颗粒和rTMS靶向治疗脑梗死后神经和血管再生的IRF9/RTN4/RHOA/ROCK通路

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-18 DOI: 10.1002/adhm.202501846

Fangfang Zhang, Weijin Shen, Siting Zhong, Kai Wen, Hongxing Wang

{"title":"Therapeutic Targeting of the IRF9/RTN4/RHOA/ROCK Pathway via RVG29-Modified PLGA Nanoparticles and rTMS for Neural and Vascular Regeneration Post-Cerebral Infarction.","authors":"Fangfang Zhang, Weijin Shen, Siting Zhong, Kai Wen, Hongxing Wang","doi":"10.1002/adhm.202501846","DOIUrl":"https://doi.org/10.1002/adhm.202501846","url":null,"abstract":"Cerebral infarction, a leading cerebrovascular disease, often results in severe neurological impairments and high mortality. This study investigates a novel therapeutic approach involving small interfering RNA targeting Interferon Regulatory Factor 9 (si-IRF9) delivered by RVG29-functionalized poly(lactic-co-glycolic acid) nanoparticles (NPs) (RVG29-PNPs@si-IRF9), in combination with high-frequency repetitive transcranial magnetic stimulation (rTMS), in promoting post-stroke regeneration. Using a middle cerebral artery occlusion rat model and an in vitro oxygen-glucose deprivation/reoxygenation system, the regenerative efficacy of this combinatory therapy is evaluated on both neural and vascular recovery. Mechanistically, our results identify the IRF9/Reticulon 4 (RTN4)/Ras homolog family member A (RHOA)/Rho-associated coiled-coil containing protein kinase (ROCK) pathway as a key mediator, which is effectively inhibited by RVG29-PNPs@si-IRF9. This inhibition enhances neurogenesis and angiogenesis, particularly when combined with rTMS. Moreover, the NP system demonstrates excellent biocompatibility and targeted delivery, highlighting its potential as a therapeutic platform for stroke rehabilitation. These findings provide a new perspective on integrating nanotechnology and neuromodulation to facilitate functional recovery after cerebral infarction.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e01846"},"PeriodicalIF":9.6,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145084676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shedding Light on the Cellular Uptake Mechanisms of Bioactive Glass Nanoparticles as Controlled Intracellular Delivery Platforms: A Review of the Recent Literature. 揭示生物活性玻璃纳米颗粒作为受控细胞内递送平台的细胞摄取机制：近期文献综述。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-18 DOI: 10.1002/adhm.202502754

Andrada-Ioana Damian-Buda, Aldo R Boccaccini

{"title":"Shedding Light on the Cellular Uptake Mechanisms of Bioactive Glass Nanoparticles as Controlled Intracellular Delivery Platforms: A Review of the Recent Literature.","authors":"Andrada-Ioana Damian-Buda, Aldo R Boccaccini","doi":"10.1002/adhm.202502754","DOIUrl":"https://doi.org/10.1002/adhm.202502754","url":null,"abstract":"Recent advancements in nanotechnology have enabled the synthesis of bioactive glass nanoparticles (BGNs), promising multifunctional platforms for the simultaneous delivery of therapeutic ions and biomolecules. However, the intracellular efficiency of BGNs is limited by the internalization mechanism, further dictating the intracellular trafficking and fate. Following a general overview of the main uptake pathways of nanoparticles and the subsequent intracellular localization, a comprehensive analysis of the BGNs' internalization process is presented. Key findings reveal that the BGNs are mainly internalized by active transport mechanisms and are entrapped in endosomes/lysosomes, limiting their ability to exert their full intracellular therapeutic potential. Existing studies in the literature provide valuable data to correlate the uptake process with the intracellular BGN localization, but there is limited research on the fate of BGNs and the released ions once entrapped in intracellular vesicles. Therefore, in the last part, future strategies to either escape the endosome or use the lysosomal degradation as a mechanism for controlled intracellular ion release with implications for targeted modulation of cell behavior are discussed. Going beyond BGNs, this review highlights the need of understanding better the dynamically transforming degradable nanoparticles - an essential step toward achieving their full intracellular therapeutic potential.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e02754"},"PeriodicalIF":9.6,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stretchable Dry Adhesives for Robust Epidermal Biosignal Sensing (Adv. Healthcare Mater. 24/2025) 用于强健表皮生物信号传感的可拉伸干胶粘剂（ad . Healthcare Mater. 24/2025）

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-18 DOI: 10.1002/adhm.70211

Eunseo Noh, Hyun-Kyung Um, Hee Jung Park, Mary Kim, Minjae Kim, Sangryun Lee, Hyang Woon Lee, Jung-Rok Lee, Byoung Hoon Lee

引用次数: 0

Issue Information: Adv. Healthcare Mater. 24/2025 发布信息：Adv. Healthcare Mater. 24/2025

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-18 DOI: 10.1002/adhm.70206

引用次数: 0

High Ultrasonic Current Density Hollow Nanorods Hijack Endogenous Iron for Accelerated Tumor Piezocatalytic Therapy. 高超声电流密度中空纳米棒劫持内源性铁加速肿瘤压催化治疗。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-18 DOI: 10.1002/adhm.202503428

Jiarui Wang, Gao He, Jilin Zhong, Xujian Yang, Hongpeng You, Shuyan Song, Lile Dong

{"title":"High Ultrasonic Current Density Hollow Nanorods Hijack Endogenous Iron for Accelerated Tumor Piezocatalytic Therapy.","authors":"Jiarui Wang, Gao He, Jilin Zhong, Xujian Yang, Hongpeng You, Shuyan Song, Lile Dong","doi":"10.1002/adhm.202503428","DOIUrl":"https://doi.org/10.1002/adhm.202503428","url":null,"abstract":"Insufficient charge separation and sluggish carrier transport hinder the development of piezocatalytic therapy. To overcome these limitations, polyvinyl pyrrolidone-modified hollow amorphous ruthenium telluride (RTP) nanorods are ingeniously engineered, providing a stepwise countermeasure for the synergistic treatment of apoptosis and ferroptosis. Compared to traditional piezocatalytic sensitizers, RTP exhibits unique advantages: I) a high piezoelectric coefficient (d33: 23.1 pmV-1), II) overlapping energy bands (-0.20 eV), and III) significantly higher US current density (200.3 nA cm-2). Importantly, this elevated US current density not only accelerates the conversion of endogenous iron (Fe3+/Fe2+), leading to iron overload, but also generates reactive oxygen species (ROS) storms, ultimately inducing oxidative stress and ferroptosis efficiently. This ingeniously designed nanoplatform, embodying \"exogenous energy harvesting synergized with endogenous ion utilization,\" serves as a promising candidate for efficient piezoelectric nanomedicine.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e03428"},"PeriodicalIF":9.6,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Programmed Aggregation of Lipidated Nitrobenzoselenadiazole as a Photo-Activatable Pyroptosis Inducer (Adv. Healthcare Mater. 24/2025) 脂化硝基苯并硒二唑的程序化聚集作为光激活的焦亡诱导剂（ad . Healthcare Mater. 24/2025）

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-18 DOI: 10.1002/adhm.70207

Jong Min An, Hyunyoung Choi, Hyo In Kim, Do-Yeon Kim, Jahyun Kim, Jinbong Park, Junyang Jung, Na Young Jeong, Dokyoung Kim

引用次数: 0

3D-Printed Scaffolds Promote Enhanced Spinal Organoid Formation for Use in Spinal Cord Injury (Adv. Healthcare Mater. 24/2025) 3d打印支架促进脊髓类器官形成，用于脊髓损伤（ad . Healthcare Mater. 24/2025）

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-18 DOI: 10.1002/adhm.70212

Guebum Han, Nicolas S. Lavoie, Nandadevi Patil, Olivia G. Korenfeld, Hyunjun Kim, Manuel Esguerra, Daeha Joung, Michael C. McAlpine, Ann M. Parr

引用次数: 0