Advanced Healthcare Materials最新文献_第7页

Bioinspired Carbon Dots with Multi-Enzyme Activity, Single-Atom Catalytic, High Efficiency ROS Scavenging and Antioxidant Therapy for Rheumatoid Arthritis. 具有多酶活性、单原子催化、高效活性氧清除和抗氧化治疗类风湿性关节炎的仿生碳点。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-05-19 DOI: 10.1002/adhm.202500207

Qian He, Ruijiao Li, Jiawen Liu, Zewen Wu, Lin Liu, Bin Xu, Liyun Zhang

{"title":"Bioinspired Carbon Dots with Multi-Enzyme Activity, Single-Atom Catalytic, High Efficiency ROS Scavenging and Antioxidant Therapy for Rheumatoid Arthritis.","authors":"Qian He, Ruijiao Li, Jiawen Liu, Zewen Wu, Lin Liu, Bin Xu, Liyun Zhang","doi":"10.1002/adhm.202500207","DOIUrl":"https://doi.org/10.1002/adhm.202500207","url":null,"abstract":"Carbon dots (CDs) with enzyme-like activity have garnered significant attention due to their ability to mimic the catalytic functions of natural enzymes, making them suitable for specific biochemical reactions in biological environments. However, the development of CDs with multi-enzyme activities remains a challenge due to the inherent complexity of incorporating multiple catalytic functions into a single nanostructure. Here, the synthesis of multi-enzyme active CDs are successfully demonstrated via a hydrothermal process utilizing hemin chloride and urea as precursors. Detailed structural and theoretical investigations reveal that the CDs possess a highly graphitized π-electron system and single-atom iron centers arranged in a monodisperse, four-coordinate configuration with nitrogen atoms. This distinctive structural configuration imparts CDs with multiple enzyme-like activities, including superoxide dismutase and catalase, which contribute to the efficient scavenging of reactive oxygen species. Furthermore, encapsulating these CDs within macrophage membranes enables selective targeting of inflammatory sites and circumvention of immune clearance in a collagen-induced arthritis rat model, offering a targeted and effective antioxidant therapy for rheumatoid arthritis.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2500207"},"PeriodicalIF":10.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CLDN18.2 CAR-derived Extracellular Vesicle Immunotherapy Improves Outcome in Murine Pancreatic Cancer. CLDN18.2 car衍生的细胞外囊泡免疫治疗改善小鼠胰腺癌的预后。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-05-19 DOI: 10.1002/adhm.202500546

Yue Qing, Ke Jiang, Hua Jiang, Yaru Zhao, Chu-Hu Lai, Alexandra Aicher, Zonghai Li, Christopher Heeschen

{"title":"CLDN18.2 CAR-derived Extracellular Vesicle Immunotherapy Improves Outcome in Murine Pancreatic Cancer.","authors":"Yue Qing, Ke Jiang, Hua Jiang, Yaru Zhao, Chu-Hu Lai, Alexandra Aicher, Zonghai Li, Christopher Heeschen","doi":"10.1002/adhm.202500546","DOIUrl":"https://doi.org/10.1002/adhm.202500546","url":null,"abstract":"Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with no current effective treatment options. Chimeric antigen receptor (CAR) T cell therapy represents a powerful immunotherapeutic approach but faces major limitations in PDAC due to complex manufacturing and reduces efficacy within the highly immunosuppressive tumor microenvironment (TME). Small extracellular vesicles (sEVs) derived from CAR-T cells present a novel strategy to address these challenges. Here, CLDN18.2 CAR-T cells are used to generate CAR-sEVs via ultracentrifugation. The purified CAR-sEVs exhibit typical sEV size and morphology, containing established sEV markers, and carry functional CAR proteins along with cytotoxic molecules such as granzyme B. In vitro, CAR-sEVs displays potent cytotoxic activity against murine CLDN18.2+ PDAC cells, whereas no significant effects are observed in CLDN18.2- non-transformed cells. In an aggressive orthotopic murine PDAC model, CAR-sEV administration reduces tumor growth as measured by bioluminescence imaging and significantly extends survival. Notably, CAR-sEVs also significantly prolong survival compared to treatment with conventional CLDN18.2-targeting CAR-T cells, further supporting their therapeutic potential. Moreover, unlike CAR-T cells, CAR-sEVs do not induce systemic IL-6 release in vivo. These findings position CLDN18.2 CAR-sEVs as a promising therapeutic modality for PDAC, offering an innovative and potentially safer platform for solid tumor immunotherapy.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2500546"},"PeriodicalIF":10.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing Aggregation-Induced Emission and Multi-FRET Strategies in a Single Conjugated Polymer Nanosystem for Enhanced Antibacterial Phototheranostics at Minimal Dosage. 在单共轭聚合物纳米系统中利用聚集诱导发射和多fret策略在最小剂量下增强抗菌光疗。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-05-19 DOI: 10.1002/adhm.202500794

Chunhong Zhu, Sameer Hussain, Ziyu Yue, Kaili Wang, Long Zhang, Mohammad Adil Afroz, Chunqiang Liu, Cibin Zhao, Xinyu Zhang, Ansar Abbas, Jingang An, Yi Hao, Ruixia Gao

{"title":"Harnessing Aggregation-Induced Emission and Multi-FRET Strategies in a Single Conjugated Polymer Nanosystem for Enhanced Antibacterial Phototheranostics at Minimal Dosage.","authors":"Chunhong Zhu, Sameer Hussain, Ziyu Yue, Kaili Wang, Long Zhang, Mohammad Adil Afroz, Chunqiang Liu, Cibin Zhao, Xinyu Zhang, Ansar Abbas, Jingang An, Yi Hao, Ruixia Gao","doi":"10.1002/adhm.202500794","DOIUrl":"https://doi.org/10.1002/adhm.202500794","url":null,"abstract":"Developing effective antibacterial photosensitizers with excellent fluorescence properties, enhanced reactive oxygen species (ROS) generation, and low dosage requirements is highly desirable but remains a major challenge. Herein, a new aggregation-induced emission (AIE)-active conjugated polymer (FTDM) with remarkable light-harvesting properties is designed and synthesized by smartly engineering AIE and multi-FRET processes in its molecular structure. Thanks to donor-π-acceptor configuration, involvement of multi-FRET mechanisms, and the notable AIE effect, the as-fabricated water dispersible nanoparticles of FTDM (FTDM NPs) demonstrate outstanding fluorescence properties and high ROS generation ability compared to a non-AIE model conjugated polymer (FDM) and the common photosensitizer Chlorin E6. Efficient fluorescence bioimaging and photodynamic antibacterial activity are achieved using FTDM NPs under white light irradiation (20 mW cm-2) for 15 min, demonstrating over 99.99% efficacy against E. coli at a remarkably low dosage of 0.6 µg mL-1. Furthermore, a mechanically stable hydrogel matrix (FTDM NPs@gel) for use as a wound dressing is attained which demonstrated accelerated wound healing by inhibiting and eliminating bacteria through the photodynamic effect in an infected mouse model without causing any toxicity. Thus, intelligently designed photodynamic antimicrobial nanosystems can be revolutionary in minimizing the toxicity and combating the menace of drug resistance.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2500794"},"PeriodicalIF":10.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resorbable 3D-Printed Osteosynthetic Plates for Rib Fracture Repair. 用于肋骨骨折修复的可吸收3d打印骨合成板。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-05-19 DOI: 10.1002/adhm.202500409

Emily K Augustine, Adrian Camarena, Taylor R Klein, Lillian Kang, Georgia Wimmer, Natasha C Stinson, Joseph S Fernandez-Moure, Matthew L Becker

{"title":"Resorbable 3D-Printed Osteosynthetic Plates for Rib Fracture Repair.","authors":"Emily K Augustine, Adrian Camarena, Taylor R Klein, Lillian Kang, Georgia Wimmer, Natasha C Stinson, Joseph S Fernandez-Moure, Matthew L Becker","doi":"10.1002/adhm.202500409","DOIUrl":"https://doi.org/10.1002/adhm.202500409","url":null,"abstract":"Rib fractures are common among blunt chest trauma patients and are a hallmark of severe thoracic injury with high morbidity and mortality rates. The standard treatment of most rib fracture cases is limited to pain control and respiratory support, with the surgical stabilization of rib fractures (SSRF) using titanium plates reserved for severely injured patients. Although SSRF has been shown to improve long-term patient outcomes, its expanded use has been limited by the invasiveness of the procedure and a lack of safe and effective resorbable fixation materials. While resorbable metal and polymeric plates have each been used in the clinic, many failures have been reported and challenges remain to control the mechanical properties of the plate during the degradation process. The 3D printing of resorbable, fumarate-based copolyester-hydroxyapatite (HAp) composite osteosynthetic plates for use in SSRF is presented, and assess their efficacy in vivo in a rabbit rib fracture model. Compared to rigid titanium fixation plates, ribs fixed with 3D printed composite plates elicit fracture calluses with decreased inflammatory response, enhanced osseointegration, and bone morphometry at 2- and 4-weeks post-fracture comparable to clinically used titanium plates.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2500409"},"PeriodicalIF":10.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Injectable Alginate/β-TCP Composite Hydrogel Incorporating P34HB/MgO+PEG Coaxial Electrospun Microfibers for Minimally Invasive Treatment of Osteonecrosis. 含有P34HB/MgO+PEG同轴静电纺微纤维的海藻酸盐/β-TCP复合水凝胶用于微创治疗骨坏死。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-05-19 DOI: 10.1002/adhm.202500617

Yu Hu Zhou, Zi Hao Zou, Jian Xiang Teng, Zhan Yu Wu, Si Wei Luo, Xu Ning, Chuan Ye, Long Yang, Wei Seong Toh

{"title":"Injectable Alginate/β-TCP Composite Hydrogel Incorporating P34HB/MgO+PEG Coaxial Electrospun Microfibers for Minimally Invasive Treatment of Osteonecrosis.","authors":"Yu Hu Zhou, Zi Hao Zou, Jian Xiang Teng, Zhan Yu Wu, Si Wei Luo, Xu Ning, Chuan Ye, Long Yang, Wei Seong Toh","doi":"10.1002/adhm.202500617","DOIUrl":"https://doi.org/10.1002/adhm.202500617","url":null,"abstract":"Avascular necrosis of the femoral head (ANFH) is a debilitating musculoskeletal disorder that is typically caused by impaired blood supply to the hip joint. In treating irregular bone defects that resulted from ANFH, injectable hydrogels are particularly attractive as they can be administered in a minimally invasive manner and conform to the variable shape of a bone defect. However, they often lack the biochemical and mechanical properties for effective bone repair. To address these issues, an injectable composite hydrogel, SA/β-TCP@PMP, composed of sodium alginate (SA) and β-tricalcium phosphate (β-TCP) crosslinked with glucono-delta-lactone (GDL), and enforced with varying concentrations of poly(3-hydroxybutyrate-co-4-hydroxybutyrate)/magnesium oxide and polyethylene glycol (P34HB/MgO+PEG; PMP) coaxial electrospun microfibers are formulated. By varying the concentrations (0%, 1%, 2%, 4%) of PMP microfibers, the physical properties of the composite hydrogel, including its injectability, surface morphology, swelling, degradation, and mechanical properties, as well as magnesium ions (Mg2+) release can be finely tuned. Among all, SA/β-TCP@2%PMP composite hydrogel demonstrates superior angiogenic and osteogenic properties, and promotes robust new bone formation in a rabbit model of steroid-induced ANFH. Overall, this novel composite hydrogel offers significant application potential for minimally invasive treatment of irregular bone lesions in ANFH.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2500617"},"PeriodicalIF":10.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioprinting Perfusable and Vascularized Skeletal Muscle Flaps for the Treatment of Volumetric Muscle Loss (Adv. Healthcare Mater. 13/2025) 生物打印可灌注和带血管的骨骼肌瓣用于治疗体积性肌肉损失（ad . Healthcare Mater. 13/2025）

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-05-16 DOI: 10.1002/adhm.202570076

Eliana O. Fischer, Anna Tsukerman, Majd Machour, Margarita Shuhmaher, Asaf Silverstein, Maya Yaakov, Orit Bar-Am, Lior Debbi, Shulamit Levenberg

引用次数: 0

Multifunctional Carbon Quantum Dots for Monitoring and Therapy of Bacterial Infected Wounds (Adv. Healthcare Mater. 13/2025) 多功能碳量子点监测和治疗细菌感染伤口（医疗保健材料，13/2025）

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-05-16 DOI: 10.1002/adhm.202570081

Wenxin Qi, Yihao Liu, Naijun Dong, Mengting Li, Jianxin Zhou, Yijun Xie, Qing Chang, Benxiang Luo, Christian Celia, Jiao Wang, Robert Chunhua Zhao, Xiaoyong Deng

引用次数: 0

Ischemic Myocardium Targeting Peptide-Guided Nanobubbles for Multimodal Imaging and Treatment of Coronary Microvascular Dysfunction (Adv. Healthcare Mater. 13/2025) 靶向肽引导的缺血心肌纳米泡多模态成像及治疗冠状动脉微血管功能障碍（Adv. Healthcare Mater. 13/2025）

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-05-16 DOI: 10.1002/adhm.202570080

Bo Yu, Ziwei Pang, Jing Zhao, Jingyi Xue, Hsuan Lo, Tiancheng Gu, Ping Zhang, Jiawei Tian, Guo-Qing Du

引用次数: 0

Ultrasmall Nanoparticles Mitigate Tau Hyperphosphorylation to Restore Synaptic Integrity and Boost Cognitive Function in Alzheimer's Disease. 超小纳米颗粒减轻Tau过度磷酸化以恢复突触完整性并增强阿尔茨海默病的认知功能。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-05-16 DOI: 10.1002/adhm.202500941

Hanbing Xu, Gang Wang, Zhilin Jiang, Yaobao Han, Weiming Zhao, Hao Zhang, Hong Liu, Huayue Liu, Zhen Li, Fuhai Ji

{"title":"Ultrasmall Nanoparticles Mitigate Tau Hyperphosphorylation to Restore Synaptic Integrity and Boost Cognitive Function in Alzheimer's Disease.","authors":"Hanbing Xu, Gang Wang, Zhilin Jiang, Yaobao Han, Weiming Zhao, Hao Zhang, Hong Liu, Huayue Liu, Zhen Li, Fuhai Ji","doi":"10.1002/adhm.202500941","DOIUrl":"https://doi.org/10.1002/adhm.202500941","url":null,"abstract":"Tau hyperphosphorylation represents a critical pathological hallmark of Alzheimer's disease (AD), a prevalent neurodegenerative disorder characterized by progressive cognitive decline. The ubiquitin-specific proteases 14 (USP14) impairs proteasomal function and accelerates hyperphosphorylated Tau accumulation, making it an attractive therapeutic target for modulating the ubiquitin-proteasome pathway in AD treatment. In this study, it is reported that wogonoside-functionalized ultrasmall Cu2-xSe nanoparticles (CSPW NPs) significantly reduce hyperphosphorylated Tau accumulation and alleviate AD symptoms. The therapeutic mechanism involves activation of the ubiquitin-proteasome pathway through USP14 inhibition by CSPW NPs, thereby preventing hyperphosphorylated Tau accumulation. Furthermore, after cell membrane coating (CSPW@CM NPs), these nanoparticles efficiently cross the blood-brain barrier with focused ultrasound assistance and accumulate in the brain to target neurons. Within neurons, they inhibit USP14, reduce phosphorylated Tau deposition, enhance microtubule stability, mitigate synaptic loss, restore synaptic integrity, and ultimately alleviate cognitive dysfunction in AD mice. The findings highlight the substantial potential of USP14 modulation for mitigating Tau hyperphosphorylation in the treatment of AD and related tauopathies.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2500941"},"PeriodicalIF":10.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Issue Information: Adv. Healthcare Mater. 13/2025 发布信息：Adv. Healthcare Mater. 13/2025

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-05-16 DOI: 10.1002/adhm.202570078

引用次数: 0