Tumor-Targeted Exosome-Based Heavy Atom-Free Nanosensitizers With Long-Lived Excited States for Safe and Effective Sono-Photodynamic Therapy of Solid Tumors (Adv. Healthcare Mater. 18/2025)

IF 10 2区医学 Q1 ENGINEERING, BIOMEDICAL

Advanced Healthcare Materials Pub Date : 2025-07-16 DOI:10.1002/adhm.202570106

Van-Nghia Nguyen, Thuy Giang Nguyen Cao, Hyunsun Jeong, Quan Truong Hoang, Binh T. T. Pham, Jieun Bang, Chang Woo Koh, Ji Hee Kang, Jeong Hyun Lee, Xiaofeng Wu, Won Jong Rhee, Young Tag Ko, K. M. K. Swamy, Sungnam Park, JaeHong Park, Min Suk Shim, Juyoung Yoon

引用次数: 0

Abstract

Sono-Photodynamic Cancer Therapy

In article 2500927, JaeHong Park, Min Suk Shim, Juyoung Yoon, and co-workers introduce tumor-targeted exosomes encapsulating a heavy atom-free nanosensitizer (IR820-TPE) for fluorescence imaging-guided sono-photodynamic cancer therapy. The IR820-TPE-loaded exosomes efficiently generate ROS via both type I and II pathways and eradicate tumors under near-infrared light and ultrasound irradiation.

Abstract Image

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基于肿瘤靶向外泌体的长寿命激发态重原子无纳米增敏剂用于安全有效的实体肿瘤声光动力治疗（adh . Healthcare Mater. 18/2025）

在文章2500927中，JaeHong Park, Min Suk Shim， Juyoung Yoon及其同事介绍了肿瘤靶向外泌体包被重原子无纳米敏化剂（IR820-TPE）用于荧光成像引导的声光动力癌症治疗。负载ir820 - tpe的外泌体通过I型和II型途径有效产生ROS，并在近红外光和超声照射下根除肿瘤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Healthcare Materials 工程技术-生物材料

CiteScore

14.40

自引率

3.00%

发文量

600

审稿时长

1.8 months

期刊介绍： Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.