Advanced Healthcare Materials最新文献_第6页

A "Janus" Zwitterionic Hydrogel Patch for Tissue Repair and Prevention of Post-Operative Adhesions.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-06 DOI: 10.1002/adhm.202404082

Jing Zhang, Xinxin Luo, Jiaqi Liu, Minmin Wu, Jie Feng, Jia Zhou

{"title":"A \"Janus\" Zwitterionic Hydrogel Patch for Tissue Repair and Prevention of Post-Operative Adhesions.","authors":"Jing Zhang, Xinxin Luo, Jiaqi Liu, Minmin Wu, Jie Feng, Jia Zhou","doi":"10.1002/adhm.202404082","DOIUrl":"https://doi.org/10.1002/adhm.202404082","url":null,"abstract":"Anti-peritoneal adhesions (PA) are very important after abdominal surgery for that PA often leads to other medical problems and imposes a huge financial burden on the national healthcare system. In this work, a \"Janus\" zwitterionic hydrogel patch where one side can adhere firmly to the tissue, while the other side has anti-fouling properties and has little interaction with the surrounding tissue has been developed. The \"Janus\" hydrogel patch is prepared by in situ formation of a bonding polymer layer poly(acrylic-co-N-hydroxysuccinimide acrylate) on one side of zwitterionic hydrogel. The mechanical, swelling, adhesion, biodegradability and biocompatibility tests are performed to study the function of \"Janus\" hydrogel patch to prevent wound adhesion and rapid repair. It is found that the adhesive side of the hydrogel patch has stable adhesion to tissues, avoiding the slippage faced by many commercial anti-adhesion gels in the body. The other zwitterionic side can resist proteins and fibroblasts and prevent external interactions or adhesion with other tissues. This convenient and effective method provides a new idea for the design of postoperative anti-adhesion materials and broadens the application of hydrogels in the biomedical field.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2404082"},"PeriodicalIF":10.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasmall High-Entropy-Alloy Nanozyme Catalyzed In Vivo ROS and NO Scavenging for Anti-Inflammatory Therapy.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-06 DOI: 10.1002/adhm.202402005

Daeeun Choi, Yeonju Boo, Seonhye Park, Liangliang Xu, Seongbeen Kim, Seung Yeop Yi, Sangmin Lee, Ruopeng Wu, Won Jong Kim, Jinwoo Lee

{"title":"Ultrasmall High-Entropy-Alloy Nanozyme Catalyzed In Vivo ROS and NO Scavenging for Anti-Inflammatory Therapy.","authors":"Daeeun Choi, Yeonju Boo, Seonhye Park, Liangliang Xu, Seongbeen Kim, Seung Yeop Yi, Sangmin Lee, Ruopeng Wu, Won Jong Kim, Jinwoo Lee","doi":"10.1002/adhm.202402005","DOIUrl":"https://doi.org/10.1002/adhm.202402005","url":null,"abstract":"High-entropy alloy (HEA) nanoparticles possess finely tunable and multifunctional catalytic activity due to their extremely diverse adsorption sites. Their unique properties enable HEA nanoparticles to mimic the complex interactions of the redox homeostasis system, which is composed of cascade and multiple enzymatic reactions. The application of HEAs in mimicking complex enzymatic systems remains relatively unexplored, despite the importance of regulating biological redox reactions. Here, it is reported that ultra-small (<10 nm in a diameter) HEA nanozymes consisting of five platinum-group metals with tunable morphologies from planar to dendritic structures are synthesized. The synthesized HEA nanozymes exhibited higher peroxidase-like activity compared to monometallic platinum-group nanoparticles. Additionally, HEA nanoparticles effectively mimicked RONS-regulation metabolism in cascade reactions involving superoxide dismutase and catalase, as well as in multiple reactions including HORAC and NO scavenging. As a result, the HEA nanozyme exhibited superior anti-inflammatory efficacy both in vitro and in vivo. The findings underscore the effectiveness of the high-entropy alloy structure in restoring in vivo enzymatic systems through intrinsic activity enhancements and cascade reaction mechanisms.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2402005"},"PeriodicalIF":10.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D Biofabrication of Microporous Hydrogels for Tissue Engineering.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-06 DOI: 10.1002/adhm.202403583

Ziyang Liu, Jialin Wu, Zeyu Luo, Yingying Hou, Leyan Xuan, Changyi Xiao, Jishuo Chang, Dongyang Zhang, Guodong Zheng, Jie Guo, Guosheng Tang, Xiyong Yu

{"title":"3D Biofabrication of Microporous Hydrogels for Tissue Engineering.","authors":"Ziyang Liu, Jialin Wu, Zeyu Luo, Yingying Hou, Leyan Xuan, Changyi Xiao, Jishuo Chang, Dongyang Zhang, Guodong Zheng, Jie Guo, Guosheng Tang, Xiyong Yu","doi":"10.1002/adhm.202403583","DOIUrl":"https://doi.org/10.1002/adhm.202403583","url":null,"abstract":"Microporous hydrogels have been utilized in an unprecedented manner in the last few decades, combining materials science, biology, and medicine. Their microporous structure makes them suitable for wide applications, especially as cell carriers in tissue engineering and regenerative medicine. Microporous hydrogel scaffolds provide spatial and platform support for cell growth and proliferation, which can promote cell growth, migration, and differentiation, influencing tissue repair and regeneration. This review gives an overview of recent developments in the fabrication techniques and applications of microporous hydrogels. The fabrication of microporous hydrogels can be classified into two distinct categories: fabrication of non-injectable microporous hydrogels including freeze-drying microporous method, two-phase sacrificial strategy, 3D biofabrication technology, etc., and fabrication of injectable microporous hydrogels mainly including microgel assembly. Then, the biomedical applications of microporous hydrogels in cell carriers for tissue engineering, including but not limited to bone regeneration, nerve regeneration, vascular regeneration, and muscle regeneration are emphasized. Additionally, the ongoing and foreseeable applications and current limitations of microporous hydrogels in biomedical engineering are illustrated. Through stimulating innovative ideas, the present review paves new avenues for expanding the application of microporous hydrogels in tissue engineering.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403583"},"PeriodicalIF":10.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peptide-Induced Hydrogelation with Ordered Metal-Organic Framework Nanoparticles Generating Reactive Oxygen Species for Integrated Wound Repair.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-05 DOI: 10.1002/adhm.202403292

Ping Li, Yiying Li, Jiahui Yao, Li-Li Li

{"title":"Peptide-Induced Hydrogelation with Ordered Metal-Organic Framework Nanoparticles Generating Reactive Oxygen Species for Integrated Wound Repair.","authors":"Ping Li, Yiying Li, Jiahui Yao, Li-Li Li","doi":"10.1002/adhm.202403292","DOIUrl":"https://doi.org/10.1002/adhm.202403292","url":null,"abstract":"Hydrogels, with their high water content and flexible nature, are a promising class of medical dressings for combating bacterial wound infections. However, their development has been hindered by low sterilization efficiency. Here, this issue is addressed by designing a peptide hydrogel that assembles ordered metal-organic framework (MOF) nanoparticles with photocatalytic bactericidal activity. Specifically, a short peptide, Nap-Gly-Phe-Phe-His (Nap-GFFH), is used to induce the assembly of zinc-imidazolate MOF (ZIF-8) into a hydrogel (NHZ gel). This innovative structure integrates three key features: 1) ZIF-8 nanoparticles are encapsulated within the hydrogel, overcoming their inherent brittleness, insolubility, and limited moldability; 2) the ordered ZIF-8 structure enhances charge transfer, enabling efficient generation of reactive oxygen species (ROS); and 3) ZIF-8 simultaneously improves the photocatalytic bactericidal efficiency and mechanical properties of the hydrogel. The NHZ gel demonstrates remarkable antibacterial performance, achieving >99.9% and 99.99% inactivation of Escherichia coli and Staphylococcus aureus, respectively, within 15 min of simulated solar radiation. Additionally, the NHZ gel exhibits excellent biocompatibility, water retention, and exudate absorption, highlighting its broad potential for wound healing.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403292"},"PeriodicalIF":10.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Engineering of Ultrabright Biomimetic NanoGhost for Site-Selective Tumor Imaging and Biodistribution.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-04 DOI: 10.1002/adhm.202401233

Rajendra Prasad, Kumari Prerna, Mayur Temgire, Pinaki Banerjee, Rohini Kumari, Gopal C Kundu, Deeksha Hattila, Chandrashekhar Venkaraddi Mangannavar, Avtar Singh Meena, Mahadeo Gorain, Jayesh Bellare, Pranjal Chandra, Vikash Kumar Dubey

{"title":"Molecular Engineering of Ultrabright Biomimetic NanoGhost for Site-Selective Tumor Imaging and Biodistribution.","authors":"Rajendra Prasad, Kumari Prerna, Mayur Temgire, Pinaki Banerjee, Rohini Kumari, Gopal C Kundu, Deeksha Hattila, Chandrashekhar Venkaraddi Mangannavar, Avtar Singh Meena, Mahadeo Gorain, Jayesh Bellare, Pranjal Chandra, Vikash Kumar Dubey","doi":"10.1002/adhm.202401233","DOIUrl":"https://doi.org/10.1002/adhm.202401233","url":null,"abstract":"Optically active ultrabright imaging agents are shown to delineate tumor location with deep tissue visualization in pre noclinical tumor models. NanoGhosts (NGs) particles are reconstructed from the cell membrane and integrated with organic fluorophores to attain ultra-brightness for solid tumor imaging. Moreover, the integration of amphiphilic and lipophilic molecules reveals structural characteristics of NGs (≈70 nm), which also alter their brightness. Upon intravenous administration (10 mg kg-1 single dose), these ultrabright NGs (778 MESF) enable the high-resolution of tumor site and real-time tracking of vital organs with high-contrast fluorescence signals. Engineered biomimetic NGs demonstrates better resolution and tissue penetration as compared to the clinically approved indocyanine green (ICG). High precision in tumor detection (0.5 h) and strong tumor retention (24 h which is further up to 30th day) without affecting healthy tissues ensure the future scope of NGs in early-stage cancer imaging. These findings suggest that these NGs mimic the biological characteristics of native cells, enabling them to evade immune clearance and target the solid tumor naturally.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2401233"},"PeriodicalIF":10.0,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Delivery of Encapsulated Intelligent Engineered Probiotic for Inflammatory Bowel Disease Therapy.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-04 DOI: 10.1002/adhm.202403704

Zhen-Ping Zou, Zhihao Cai, Xiao-Peng Zhang, Donghui Zhang, Chu-Ying Xu, Ying Zhou, Runhui Liu, Bang-Ce Ye

{"title":"Delivery of Encapsulated Intelligent Engineered Probiotic for Inflammatory Bowel Disease Therapy.","authors":"Zhen-Ping Zou, Zhihao Cai, Xiao-Peng Zhang, Donghui Zhang, Chu-Ying Xu, Ying Zhou, Runhui Liu, Bang-Ce Ye","doi":"10.1002/adhm.202403704","DOIUrl":"https://doi.org/10.1002/adhm.202403704","url":null,"abstract":"Engineered bacterial therapy holds enormous potential for treating intestinal diseases, employing synthetic biology techniques to achieve localized drug delivery within intestines. However, effective delivery of engineered bacteria to lesion sites and ensuring sustained colonization remain challenging. Here, a mucus encapsulated microsphere gel (MM) delivery system is developed to encapsulate genetically engineered bacteria capable of detecting and treating enteritis. The MM delivery system features an external mucosal coating composed of hyaluronic acid and epigallocatechin gallate, along with internal microspheres of highly biocompatible polyserine modified alginates encapsulating with the engineered probiotics. The MM delivery system effectively protects engineered bacteria harsh environment in stomach and significantly improves intestinal adhesion of the probiotics, extending colonization up to 24 h, and does not affect the entry of biomarker or release of Avcystatin. It exhibits notable diagnostic and therapeutic efficacy in inflammatory bowel disease models, thus facilitating the advancement of live biotherapeutic products toward clinical application.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403704"},"PeriodicalIF":10.0,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liquid Crystal Elastomer for Compression Therapy.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-04 DOI: 10.1002/adhm.202402881

Gaoweiang Dong, Fangchen Zhao, Zongyu Gao, Shengqiang Cai

{"title":"Liquid Crystal Elastomer for Compression Therapy.","authors":"Gaoweiang Dong, Fangchen Zhao, Zongyu Gao, Shengqiang Cai","doi":"10.1002/adhm.202402881","DOIUrl":"https://doi.org/10.1002/adhm.202402881","url":null,"abstract":"Compression therapy is a widely used treatment for various disorders including venous leg ulcers. Traditional methods such as inelastic bandages and elastic stockings, have limitations in maintaining optimal pressure over time. Dynamic therapy devices offer intermittent pressure cycles but are often bulky or rigid. Here liquid crystal elastomer (LCE) is proposed for both static and dynamic compression therapy. Due to the soft elasticity of polydomain LCE, LCE-based static stocking can maintain consistent pressure over a wide range of leg diameters, permitting the tolerance of stocking application inconsistencies, various limb sizes, and interfacial pressure drop due to leg deswelling. The LCE-based dynamic stocking consists of monodomain LCEs with reversible thermal actuation, heating elements, and electronics. The dynamic stocking generates intermittent pressure from 20 to 60 mmHg with a slight temperature increase above 33 °C and offers pressure profile programmability. Furthermore, an untethered LCE-based dynamic compression device on a human leg is demonstrated. Both LCE-based static and dynamic stockings show minimal stress relaxation and reusability over 1000 cycles, ensuring long-term use in compression therapy applications.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2402881"},"PeriodicalIF":10.0,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Masthead: (Adv. Healthcare Mater. 30/2024)

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-04 DOI: 10.1002/adhm.202470191

引用次数: 0

Redirecting Tumor Evolution with Nanocompiler Precision for Enhanced Therapeutic Outcomes (Adv. Healthcare Mater. 30/2024)

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-04 DOI: 10.1002/adhm.202470193

Wenshe Sun, Biao Cai, Zejun Zhao, Shilun Li, Yutian He, Shaowei Xie

引用次数: 0

Chemically Defined Organoid Culture System for Cholangiocyte Differentiation (Adv. Healthcare Mater. 30/2024)

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-04 DOI: 10.1002/adhm.202470192

Zhenguo Wang, Shicheng Ye, Luc J.W. van der Laan, Kerstin Schneeberger, Rosalinde Masereeuw, Bart Spee

引用次数: 0