Advanced Healthcare Materials最新文献_第6页

Visible Light Induced DLP-Printed Oxygen-Releasing TPMS Scaffolds Mitigate Early Hypoxia in Bone Defects. 可见光诱导dlp打印的氧释放TPMS支架减轻骨缺损早期缺氧。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-23 DOI: 10.1002/adhm.202502735

Anastasia B Timoshenko, Ali Ghasemkhani, Chanul Kim, Domenic J Cordova, Maria Astudillo Potes, Valeria Aceves, Indranath Mitra, Justin E Bird, Ryan S Gray, Stephanie K Seidlits, Benjamin D Elder, Maryam Tilton

{"title":"Visible Light Induced DLP-Printed Oxygen-Releasing TPMS Scaffolds Mitigate Early Hypoxia in Bone Defects.","authors":"Anastasia B Timoshenko, Ali Ghasemkhani, Chanul Kim, Domenic J Cordova, Maria Astudillo Potes, Valeria Aceves, Indranath Mitra, Justin E Bird, Ryan S Gray, Stephanie K Seidlits, Benjamin D Elder, Maryam Tilton","doi":"10.1002/adhm.202502735","DOIUrl":"https://doi.org/10.1002/adhm.202502735","url":null,"abstract":"Oxygen deprivation within large or poorly vascularized bone defects remains a key barrier to successful regeneration, especially during the early postimplantation period before vascular ingrowth. Here, the development of COSnPPOD (CaO2-Silica NP Platform for Osteogenic Development) is reported, a visible light digital light processing-printed hydrogel scaffold that integrates oxygen-releasing nanoparticles (NPs) within a Primitive-type triply periodic minimal surface architecture. The scaffold combines a gelatin methacrylate-poly(ethylene glycol) diacrylate matrix with calcium peroxide (CaO2)-loaded hollow silica NPs, enabling localized, short-term oxygen release while preserving structural fidelity. COSnPPOD scaffolds demonstrate favorable degradation kinetics, tunable stiffness, and increased protein adsorption in vitro. In a preosteoblast model, COSnPPOD maintains cell viability and supports osteogenic gene expression without cytotoxic effects. While overall gene expression is comparable to controls, a 16-fold increased expression of phosphoprotein 1 (Spp1) suggests scaffold-driven activation of matrix remodeling pathways. In vivo, COSnPPOD scaffolds enhance bone regeneration in a murine calvarial defect model, with significantly greater bone formation and collagen deposition than untreated defects and hydrogel controls. Additionally, vascular endothelial growth factor immunostaining is increased within the defect, consistent with a proangiogenic response, and no systemic toxicity is observed. These findings establish COSnPPOD as a promising scaffold system that combines sustained oxygenation with biomimetic geometry to support localized bone regeneration.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e02735"},"PeriodicalIF":9.6,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional Immunomodulatory Hydrogel With Bacterial Capture Properties, Intelligently Exhibited Viscous or Elastic Properties and On-Demand Removal Properties for the Treatment of Bacterially Infected Irregular Chronic Wound Healing. 具有细菌捕获特性的多功能免疫调节水凝胶，智能地表现出粘性或弹性特性和按需去除特性，用于治疗细菌感染的不规则慢性伤口愈合。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-23 DOI: 10.1002/adhm.202501670

Jiakang Zhang, Yuhui Zhang, Tao Fu, Jie Li, Zishuo Wang, Wenjing Yang, Long Chen, Qian Liu, Wencheng Liang, Yuntong Zhang, Shuo Fang, Meidong Lang

{"title":"Multifunctional Immunomodulatory Hydrogel With Bacterial Capture Properties, Intelligently Exhibited Viscous or Elastic Properties and On-Demand Removal Properties for the Treatment of Bacterially Infected Irregular Chronic Wound Healing.","authors":"Jiakang Zhang, Yuhui Zhang, Tao Fu, Jie Li, Zishuo Wang, Wenjing Yang, Long Chen, Qian Liu, Wencheng Liang, Yuntong Zhang, Shuo Fang, Meidong Lang","doi":"10.1002/adhm.202501670","DOIUrl":"https://doi.org/10.1002/adhm.202501670","url":null,"abstract":"Bacterial infections can trigger disturbances in the wound's internal environment and overstimulate the inflammatory stress response, causing the formation of chronic wounds and even tricky complications. However, irregular wounds with intricate crevices are prone to hoarding tissue exudate and colonising bacteria. This creates unnecessary headaches for patients and the healthcare system. Herein, a multifunctional immunomodulatory hydrogel for the healing of irregular chronic wounds with bacterial infections is developed. The system, based on the reversible fracture-restructuring property of dynamic chemical bonds, endows the elastic hydrogel with the viscous fluid property. Meanwhile, the bacterial capture properties are utilised to confer the hydrogel with mild and effective antimicrobial properties. By gradually eliminating bacteria and clearing bacteria and bacterial debris from the lesion, the immune stress response is modulated. In addition, the hydrogel adhering to the wound is painlessly removed by dissociation and disruption of the topological cross-linking points. Histopathological analyses revealed that hydrogels alleviate the inflammatory infiltrative condition at the lesion, accelerate the process of angiogenesis and re-epithelialisation, and facilitate the remodelling of the skin and its appendages. Therefore, the multifunctional immunomodulatory hydrogel constructed in this study can efficiently manage the healing of irregular chronic wounds with bacterial infections.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e01670"},"PeriodicalIF":9.6,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145129572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermochromic, Antibacterial, and Conductive Hydrogel Patch with Sandwich Structure for Visual Infectious Chronic Wound Care and Treatment. 热致变色、抗菌、导电的三明治结构水凝胶贴片，用于视觉感染性慢性伤口的护理与治疗。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-22 DOI: 10.1002/adhm.202503296

Yuanyuan Yang, Qiaoyu Huang, Yong Hu, Yige Chen, Jiayi Chen, Zhaoxia Chen, Xueliang Jiang, Yuhong Zhang

{"title":"Thermochromic, Antibacterial, and Conductive Hydrogel Patch with Sandwich Structure for Visual Infectious Chronic Wound Care and Treatment.","authors":"Yuanyuan Yang, Qiaoyu Huang, Yong Hu, Yige Chen, Jiayi Chen, Zhaoxia Chen, Xueliang Jiang, Yuhong Zhang","doi":"10.1002/adhm.202503296","DOIUrl":"https://doi.org/10.1002/adhm.202503296","url":null,"abstract":"Multifunctional smart hydrogel dressings that combine diagnosis and treatment are a popular solution for the care and treatment of infectious wounds. Herein, a sandwich structure hydrogel patch (PTP) composed of tannic acid modified gelatin (TGL) as the middle layer and polyvinyl alcohol hydrogel with sodium chloride and iodine (PAI/NS) as the inner and outer layer is successfully designed and assembled. The obtained PTP exhibits good mechanical performance, outstanding biocompatibility, and robust electrical conductivity. When attached to an active wound, the change of electrical signal caused by the movement of conductive ions (Na+ and Cl-) in PAI/NS would reflect the integrity and fit of the gel patch. Meanwhile, the increased temperature of the wound elicits a temperature-activated acid-base color reaction between TGL and PAI/NS, indicating fever and wound infection. In turn, the infection degree of the wound is monitored to guide on-demand drug administration through photothermal antibacterial treatment. The results of in vivo and in vitro experiments demonstrate that the PTP hydrogel patch shows a remarkable anti-infection and pro-healing effect. This smart hydrogel system integrates real-time wound infection monitoring with anti-bacterial treatment, offering a viable strategy for visual, personalized management of infected chronic wounds.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e03296"},"PeriodicalIF":9.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Hydrogel with Low-Temperature Photothermal Therapy and ROS Scavenging Capability for Healing Infected Diabetic Wound. 具有低温光热治疗和清除活性氧能力的水凝胶治疗糖尿病感染伤口。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-22 DOI: 10.1002/adhm.202500355

Xin Liu, Shaopeng Liu, Bo Ma, Yang Zhang, Qianxiang Meng, Mingyue Chen, Fangye Chen, Miaomiao Tian, Song Liu, Peng Liu, Kaiyong Cai

{"title":"A Hydrogel with Low-Temperature Photothermal Therapy and ROS Scavenging Capability for Healing Infected Diabetic Wound.","authors":"Xin Liu, Shaopeng Liu, Bo Ma, Yang Zhang, Qianxiang Meng, Mingyue Chen, Fangye Chen, Miaomiao Tian, Song Liu, Peng Liu, Kaiyong Cai","doi":"10.1002/adhm.202500355","DOIUrl":"https://doi.org/10.1002/adhm.202500355","url":null,"abstract":"Photothermal therapy (PTT) in antimicrobial treatment of diabetic wounds faces the challenge of damaging normal tissues with high temperatures. In this study, mesoporous polydopamine (MPDA) as the core, encapsulated by Zeolitic Imidazolate Framework-8 (ZIF-8) shell, and loaded with berberine (BBR) are used to fabricate MPDA@ZIF-8/BBR core-shell nanoparticles (NPs). Then, those NPs are incorporated into hydrogels formed by reacting carboxymethyl chitosan (CMCS) with oxidized hyaluronic acid (OHA) via Schiff base chemistry, creating a photothermal nanocomposite hydrogel capable of scavenging ROS (Gel- MPDA@ZIF-8/BBR). The hydrogel achieves low-temperature PTT antimicrobial activity by controlled degradation under the weak acidic conditions of the bacterial infection microenvironment and simultaneous release of BBR and Zn2⁺, combined with the mild photothermal effect of MPDA. The released BBR synergistically enhances the photothermal effect by inhibiting bacterial community sensing, effectively disintegrating the bacterial biofilm. More importantly, the composite hydrogels showed good biocompatibility, effectively inhibited the wound inflammatory response, and significantly accelerated wound healing, which achieved low-temperature PTT antibacterial therapy and has the potential to treat diabetic-infected chronic wounds.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e00355"},"PeriodicalIF":9.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autocrine TGF-β1 in Periodontal Ligament-Derived Stem Cell Pellets Enhances Periodontal Regeneration in Class II Furcation Defects of Canine Models. 牙周韧带来源干细胞微球自分泌TGF-β1促进犬ⅱ类功能缺损模型牙周再生

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-22 DOI: 10.1002/adhm.202502553

Fangfang Xu, Zhou Zhang, Siya Fang, Le Bai, Yuxin Gong, Xiang Liang, Ming Yu, Sina Ahmadi, Sadam Ahmed Elayah, Junbo Tu, Sijia Na

{"title":"Autocrine TGF-β1 in Periodontal Ligament-Derived Stem Cell Pellets Enhances Periodontal Regeneration in Class II Furcation Defects of Canine Models.","authors":"Fangfang Xu, Zhou Zhang, Siya Fang, Le Bai, Yuxin Gong, Xiang Liang, Ming Yu, Sina Ahmadi, Sadam Ahmed Elayah, Junbo Tu, Sijia Na","doi":"10.1002/adhm.202502553","DOIUrl":"https://doi.org/10.1002/adhm.202502553","url":null,"abstract":"The Class II furcation defects present a significant challenge in periodontal treatment and pose a considerable risk to tooth survival. While scaffold-free Periodontal ligament stem cells (PDLSCs)-derived cell pellets (CP) and sheets (CS) aid regeneration, the molecular mechanisms and efficacy of PDLSC-CP remain unclear, especially in large animals. This study investigates PDLSC-CP's regenerative potential for Class II defects through in vitro and in vivo analyses. PDLSC-CP demonstrated superior cell viability, improved the extracellular matrix (ECM) quality, enhanced biomechanical properties, and a greater potential for periodontal tissue regeneration compared to PDLSC-CS in both in vitro and in vivo scenarios. Importantly, autocrine transforming growth factor-β1 (TGF-β1) in PDLSC-CP upregulated odonto/osteogenesis-related factors by activating the TGF-β1/Smad pathway. However, LY2109761, an inhibitor of TGF-β receptor I and II, suppressed periodontal tissue regeneration in immunodeficient mice. In the beagle dog with Class II furcation defects, PDLSC-CP regenerated and repaired periodontal bone defects, which is more effective than the control group, the bone substitutes group, and the mixed group (PDLSC-CP and bone substitutes). These findings highlight PDLSC-CP as a promising strategy for periodontal bone defect treatment, where autocrine TGF-β1 stimulates the TGF-β1/Smad pathway to drive periodontal tissue regeneration.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e02553"},"PeriodicalIF":9.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Materials for Ferroptosis Inhibition: from Design to Applications. 抑制铁下垂的治疗材料：从设计到应用。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-22 DOI: 10.1002/adhm.202503407

Zipei Zhao, Hanfei Li, Xu Wang, Qianbing Wan, Jian Wang, Junyu Chen, Weifeng Zhao, Bin Cheng, Xibo Pei

{"title":"Therapeutic Materials for Ferroptosis Inhibition: from Design to Applications.","authors":"Zipei Zhao, Hanfei Li, Xu Wang, Qianbing Wan, Jian Wang, Junyu Chen, Weifeng Zhao, Bin Cheng, Xibo Pei","doi":"10.1002/adhm.202503407","DOIUrl":"https://doi.org/10.1002/adhm.202503407","url":null,"abstract":"Ferroptosis, an iron-dependent cell death process driven by lipid peroxidation, is increasingly being recognized as a pivotal mechanism in the pathogenesis and progression of numerous diseases. Emerging evidence indicates that inhibition of ferroptosis has excellent therapeutic effects against these diseases. However, the therapeutic effects of traditional ferroptosis inhibitors are limited by their nonspecific targeting and short duration of activity. Recently, novel materials with ferroptosis-inhibiting properties have emerged to effectively address these problems. This review revisits the history and key features of ferroptosis, explore its role in various diseases, and identify potential therapeutic targets. This work then introduces the diverse materials used in ferroptosis therapy, emphasizing how they are designed to target specific features of the pathological microenvironment. Finally, current challenges and future opportunities for therapeutic materials for ferroptosis-related diseases are outlined, establishing a conceptual framework to guide rational design principles for ferroptosis-targeting materials. This review should help develop new materials for ferroptosis inhibition with improved biophysicochemical properties and therapeutic effects.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e03407"},"PeriodicalIF":9.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PB@Ag₂S Nanoagent with Enhanced Blood-Brain Barrier Penetration and Synergistic Chemodynamic-Immune Therapy via Light-Induced Iron Valence Transition. PB@Ag2S纳米剂通过光诱导铁价转变增强血脑屏障穿透和协同化学动力学免疫治疗。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-22 DOI: 10.1002/adhm.202501763

Yangyang Zhao, Yuqing Wang, Dazhi Chen, Juanjuan Su, Xiaogang Liu, Hongjie Zhang, Kai Liu, Fan Wang

{"title":"PB@Ag2S Nanoagent with Enhanced Blood-Brain Barrier Penetration and Synergistic Chemodynamic-Immune Therapy via Light-Induced Iron Valence Transition.","authors":"Yangyang Zhao, Yuqing Wang, Dazhi Chen, Juanjuan Su, Xiaogang Liu, Hongjie Zhang, Kai Liu, Fan Wang","doi":"10.1002/adhm.202501763","DOIUrl":"https://doi.org/10.1002/adhm.202501763","url":null,"abstract":"Gliomas, characterized by high mortality rates, present significant therapeutic challenges due to their invasive growth, chemoresistance, and the blood-brain barrier (BBB). To address these limitations, a multifunctional Prussian blue/Ag2S nanoplatform (PB@Ag2S) is developed, integrating chemodynamic therapy, BBB modulation, and enhanced immunotherapy. Under near-infrared (NIR) irradiation, Fe2+ in Prussian blue is oxidized to Fe3+, amplifying chemodynamic therapy through hydroxyl radical generation and glutathione depletion (GSH reduced by 1.9-fold). Concurrently, Fe3+ oxidizes thiol groups in Vascular Endothelial cadherin (VE-cadherin), reducing its expression by 40.6% and transiently disrupting the BBB, thereby enhancing intracranial accumulation of the nanoplatform by 3.0-fold. Integrated Ag2S nanoparticles enable real-time treatment monitoring via NIR-II fluorescence imaging. Unlike conventional immunotherapies, which exhibit limited efficacy in glioma due to its immunosuppressive microenvironment, the PB@Ag2S platform uniquely promotes dendritic cell maturation and reprograms tumor-associated macrophages toward the anti-tumor M1 phenotype. This dual immunomodulatory action effectively converts the immunosuppressive \"cold\" tumor microenvironment into an immunologically active state. In glioma models, this multifunctional platform achieved tumor eradication within 14 days. By integrating photo-controlled multimodal actions, this theranostic platform effectively addresses critical clinical challenges in glioma therapy.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e01763"},"PeriodicalIF":9.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Hierarchically Structured, Stretchable, Anti-Biofouling Encapsulation for Biodegradable Electronics. 一种用于生物可降解电子产品的分层结构、可拉伸、抗生物污染封装。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-22 DOI: 10.1002/adhm.202503622

Won Bae Han, Sungkeun Han, Gwan-Jin Ko, Ulziituya Batjargal, Wonjun Jang, Venkata Ramesh Naganaboina, Han-Jun Kim, Suk-Won Hwang

{"title":"A Hierarchically Structured, Stretchable, Anti-Biofouling Encapsulation for Biodegradable Electronics.","authors":"Won Bae Han, Sungkeun Han, Gwan-Jin Ko, Ulziituya Batjargal, Wonjun Jang, Venkata Ramesh Naganaboina, Han-Jun Kim, Suk-Won Hwang","doi":"10.1002/adhm.202503622","DOIUrl":"https://doi.org/10.1002/adhm.202503622","url":null,"abstract":"Biodegradable polymers have been employed as encapsulants for transient, resorbable implantable devices due to moderate water permeability, mechanical flexibility, and biocompatibility, however most of them relatively lack inherent anti-biofouling properties. This limitation can lead to undesired protein adsorption, cell adhesion, and fibrotic encapsulation, compromising device function and biocompatibility, particularly for long-term implantation scenarios. Here, this study introduces a soft, stretchable, and anti-biofouling encapsulant engineered by integrating self-assembled organosilicon nanowire networks onto micropatterned biodegradable elastomers. The resulting hierarchical surface architecture imparts superhydrophobicity while preserving mechanical integrity, improving water barrier performance by up to 420% compared to unmodified films and retaining stability under cyclic strains. Integration into a transient, stretchable optoelectronic device enables prolonged operation in aqueous environments, and in vitro and in vivo evaluations demonstrate suppressed cell adhesion, reduced fibrotic tissue formation, and excellent biocompatibility, highlighting the potential for long-lasting, bioresorbable electronic implants.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e03622"},"PeriodicalIF":9.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human Endometrial Extracellular Matrix Hydrogel Facilitated Endometrial Mesenchymal Stem Cells for Endometrial Regeneration. 人子宫内膜细胞外基质水凝胶促进子宫内膜间充质干细胞的子宫内膜再生。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-21 DOI: 10.1002/adhm.202501767

Jingwen Xu, Philip C N Chiu, Ernest H Y Ng, Sentao Hu, Zi Ye, Liaobing Xin, Lie Ma, Songying Zhang, William S B Yeung, Rachel W S Chan

{"title":"Human Endometrial Extracellular Matrix Hydrogel Facilitated Endometrial Mesenchymal Stem Cells for Endometrial Regeneration.","authors":"Jingwen Xu, Philip C N Chiu, Ernest H Y Ng, Sentao Hu, Zi Ye, Liaobing Xin, Lie Ma, Songying Zhang, William S B Yeung, Rachel W S Chan","doi":"10.1002/adhm.202501767","DOIUrl":"https://doi.org/10.1002/adhm.202501767","url":null,"abstract":"The extracellular matrix (ECM) constantly remodels to tailor a temporal spatial specific environment for the residing cells to respond to physiological or pathological stimuli. Endometrial mesenchymal stem cells (eMSC) are excellent therapeutic candidates for treating endometrial problems. In-depth investigation of the native niche to understand the regulatory mechanisms of the stem cells will enable greater translational potentials in regenerating the thin or damaged endometrium. To understand the ECM niche of eMSC, endometrial ECM from full thickness human endometrial tissues at different menstrual phases are preserved by tissue decellularization and then transformed into hydrogel material (EndoGel). EndoGel exhibits excellent compatibility with eMSC by enhancing the expansion of eMSC in vitro and facilitating the therapeutic regenerative effect in vivo evidenced by the improved fertility outcome. Comparative study of the proliferative to secretory phase EndoGel reveals unique matrisome at specific phase of the human menstrual cycle. The post-regenerated endometrium shows distinct transcriptomic profile when transplanted with different menstrual phase EndoGel, suggesting the regulatory effect of the tissue matrix is menstrual phase specific. This is the first study comparing the endometrial matrix from specific human menstrual cycle and exploring its therapeutic potentials as a supportive biomaterial for eMSC to enhance endometrial regeneration.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e01767"},"PeriodicalIF":9.6,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Robust Heparin-Mimicking Polyglycerol-Based Coating for Blood-Contacting Devices with Long-Term Hemocompatibility and Preliminary Anti-Inflammatory Properties. 一种具有长期血液相容性和初步抗炎性能的模拟肝素聚甘油涂层用于血液接触装置。

IF 9.6 2区医学

Advanced Healthcare Materials Pub Date : 2025-09-21 DOI: 10.1002/adhm.202502766

Kunpeng Liu, Philip Nickl, Jun Feng, Rainer Haag

{"title":"A Robust Heparin-Mimicking Polyglycerol-Based Coating for Blood-Contacting Devices with Long-Term Hemocompatibility and Preliminary Anti-Inflammatory Properties.","authors":"Kunpeng Liu, Philip Nickl, Jun Feng, Rainer Haag","doi":"10.1002/adhm.202502766","DOIUrl":"https://doi.org/10.1002/adhm.202502766","url":null,"abstract":"Blood-contacting medical devices play a crucial role in clinical interventions, but their susceptibility to thrombosis and inflammation poses serious risks to treatment outcomes and patient safety. This study presents a novel coating that combines dendritic polyglycerol amine (dPGA), dendritic polyglycerol aldehyde (dPG-CHO), and linear polyglycerol sulfate (lPGS) using a layer-by-layer self-assembly method (LBL) on a polystyrene surface. The immobilization of dendritic polyglycerol enhances surface coverage, enabling the incorporation of a higher density of heparin-mimicking lPGS, while the covalent bonding ensures the coating's long-term stability. Compared to the pristine substrate, the coating significantly reduced platelet adhesion and activation. Notably, its hemocompatibility effects persist even after 30 days. Furthermore, co-incubation experiments with RAW264.7 macrophages confirmed the anti-inflammatory properties of the polyglycerol-based coating. These results demonstrate that this heparin-mimetic coating effectively improves the hemocompatibility of polystyrene and has the potential to be applied to other blood-contacting materials.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e02766"},"PeriodicalIF":9.6,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0