Advanced Healthcare Materials最新文献_第6页

WS₂/MHS PdTe₂/Si Mixed-Dimensional Heterojunction as Ultra-Broadband Photodetector for Health and Safety Monitoring. WS2/MHS PdTe2/Si混合维异质结用于健康安全监测的超宽带光电探测器。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-01-10 DOI: 10.1002/adhm.202402507

Cuicui Ling, Chen Rong, Boxuan Men, Jingyao Wang, Jiayi Sun, Tuo Zhang, Lingtan Zhang, Tianchao Guo, Peiheng Zhou, Wenpeng Liu

{"title":"WS2/MHS PdTe2/Si Mixed-Dimensional Heterojunction as Ultra-Broadband Photodetector for Health and Safety Monitoring.","authors":"Cuicui Ling, Chen Rong, Boxuan Men, Jingyao Wang, Jiayi Sun, Tuo Zhang, Lingtan Zhang, Tianchao Guo, Peiheng Zhou, Wenpeng Liu","doi":"10.1002/adhm.202402507","DOIUrl":"https://doi.org/10.1002/adhm.202402507","url":null,"abstract":"Ultra-broadband photodetectors (UB-PDs) are essential in medical applications, public safety monitoring, and various other fields. However, developing UB-PDs covering multiple bands from ultraviolet to medium infrared remains a challenge due to material limitations. Here, a mixed-dimensional heterojunction composed of 2D WS2/monodisperse hexagonal stacking (MHS) 3D PdTe2 particles on 3D Si is proposed, capable of detecting light from 365 to 9600 nm. The exceptional performance of this photodetector is attributed to MHS PdTe₂ particles, which increase the specific surface area and enhance UV-to-NIR absorption of the 2D WS₂ nanofilm. At 980 nm (0 V), the device achieves a responsivity of 7.8 × 102 mA W-1, a detectivity of 2.5 × 1013 Jones, and a sensitivity of 2.6 × 108 cm2 W-1. The MHS PdTe₂ layer amplifies the built-in electric field and enhances heterojunction self-powered capability. This photodetector exhibits a high switching ratio (104), a rapid response time (24.14 µs), and a significant photocurrent gain at zero bias. Its application in blood oxygen saturation analysis is demonstrated based on dual-wavelength photoplethysmography (PPG) at 650 and 905 nm, and infrared perspective imaging at 808 nm. Additionally, the device can differentiate materials based on their transmittance at 9600 nm. This research opens new avenues for the multifunctional use of UB-PDs.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2402507"},"PeriodicalIF":10.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Smart mRNA-Initiated Theranostic Multi-shRNA Nanofactory for Precise and Efficient Cancer Gene Therapy. 用于精确和高效癌症基因治疗的智能mrna启动治疗多shrna纳米工厂。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-01-10 DOI: 10.1002/adhm.202404159

Ming Shi, Yifang He, Xiaohong Zhong, Huakui Huang, Jing Hua, Shulong Wang, Jiayao Xu, Shulin Zhao, Hong Liang, Yong Huang

{"title":"A Smart mRNA-Initiated Theranostic Multi-shRNA Nanofactory for Precise and Efficient Cancer Gene Therapy.","authors":"Ming Shi, Yifang He, Xiaohong Zhong, Huakui Huang, Jing Hua, Shulong Wang, Jiayao Xu, Shulin Zhao, Hong Liang, Yong Huang","doi":"10.1002/adhm.202404159","DOIUrl":"https://doi.org/10.1002/adhm.202404159","url":null,"abstract":"Despite the significant potential of short hairpin RNA (shRNA)-mediated gene therapy for various diseases, the clinical success of cancer treatment remains poor, partly because of low selectivity and low efficiency. In this study, an mRNA-initiated autonomous multi-shRNA nanofactory (RNF@CM) is designed for in vivo amplification imaging and precise cancer treatment. The RNF@CM consists of a gold nanoparticle core, an interlayer of two types of three-stranded DNA/RNA hybrid probes, one of which is bound to aptamer-inhibited DNA polymerases, and an outer layer of the cancer cell membrane. After the specific delivery of RNF@CM into target cancer cells, an intracellular tumour-related mRNA target can initiate the RNF@CM with a circular strand-displacement polymerisation reaction, resulting in the release of significantly amplified fluorescence and continuous production of three types of shRNAs. The RNF@CM effectively distinguished cancer cells from normal cells, exclusively produced multiple shRNAs in response to a specific mRNA target in cancer cells, accurately diagnosed tumours in vivo, and significantly inhibited tumour growth with negligible toxicity, expanding the toolbox for on-demand gene delivery and precision theranostics.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2404159"},"PeriodicalIF":10.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142941560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transferrin-Based Bismuth Nanoparticles for Radiotherapy with Immunomodulation Against Orthotopic Glioma. 基于转铁蛋白的铋纳米颗粒用于放射治疗伴免疫调节的原位胶质瘤。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-01-10 DOI: 10.1002/adhm.202404144

Xiaoyu Huang, Wei Ge, Shuxian Li, Ruofan Huang, Fu Wang

引用次数: 0

Colon-Targeted Ginseng Polysaccharides-Based Microspheres for Improving Ulcerative Colitis via Anti-Inflammation and Gut Microbiota Modulation. 结肠靶向人参多糖微球通过抗炎和调节肠道菌群改善溃疡性结肠炎。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-01-10 DOI: 10.1002/adhm.202404122

De-Yang Huo, Yan-Fei Li, Ling-Jie Song, Wen-Xin Zhang, Xin-Dian Li, Jing Zhang, Shen Ren, Zi Wang, Wei Li

{"title":"Colon-Targeted Ginseng Polysaccharides-Based Microspheres for Improving Ulcerative Colitis via Anti-Inflammation and Gut Microbiota Modulation.","authors":"De-Yang Huo, Yan-Fei Li, Ling-Jie Song, Wen-Xin Zhang, Xin-Dian Li, Jing Zhang, Shen Ren, Zi Wang, Wei Li","doi":"10.1002/adhm.202404122","DOIUrl":"https://doi.org/10.1002/adhm.202404122","url":null,"abstract":"Natural plant-derived polysaccharides exhibit substantial potential for treating ulcerative colitis (UC) owing to their anti-inflammatory and antioxidant properties and favorable safety profiles. However, their practical application faces several challenges, including structural instability in gastric acid, imprecise targeting of inflamed regions, and limited intestinal retention times. To address these limitations, pH-responsive, colon-targeting microspheres (pWGPAC MSs) are developed for delivering phosphorylated wild ginseng polysaccharides (pWGP) to alleviate UC. These pWGPAC MSs are fabricated by incorporating pWGP into calcium-crosslinked alginate microspheres with subsequent chitosan surface modification to enhance mucosal adhesion. These pWGPAC MSs demonstrated exceptional stability under acidic conditions while enabling targeted release in the colon. In a mouse model of UC, the pWGPAC MSs effectively mitigated mucosal injury, attenuated inflammation, and restored intestinal barrier function. Further mechanistic investigations revealed that these pWGPAC MSs modulated the TLR4/MYD88 signaling pathway and promoted M2 macrophage polarization. Integrated microbiome and metabolome analyses demonstrated that these pWGPAC MSs regulated the gut microbiota composition and decreased pro-inflammatory metabolite levels. In addition, these microspheres demonstrated promising safety profiles. Collectively, these findings establish pWGPAC MSs as a promising therapeutic strategy for the treatment of UC and provide a solid foundation for future clinical applications.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2404122"},"PeriodicalIF":10.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunoengineering Frontiers - Transforming Healthcare Through Advanced Materials. 免疫工程前沿-通过先进材料改变医疗保健。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-01-08 DOI: 10.1002/adhm.202405290

Ankur Singh

引用次数: 0

Multifunctional Hydrogel with Photothermal ROS Scavenging and Antibacterial Activity Accelerates Diabetic Wound Healing. 具有光热活性氧清除和抗菌活性的多功能水凝胶加速糖尿病伤口愈合。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-01-08 DOI: 10.1002/adhm.202402236

Yijia Xue, Fan Yang, Yunjiao He, Feilong Wang, Dandan Xia, Yunsong Liu

{"title":"Multifunctional Hydrogel with Photothermal ROS Scavenging and Antibacterial Activity Accelerates Diabetic Wound Healing.","authors":"Yijia Xue, Fan Yang, Yunjiao He, Feilong Wang, Dandan Xia, Yunsong Liu","doi":"10.1002/adhm.202402236","DOIUrl":"https://doi.org/10.1002/adhm.202402236","url":null,"abstract":"Poor diabetic wound healing poses a critical threat to human health. Excessive oxidative stress and increased susceptibility to bacterial infection are key issues that impede diabetic wound healing. Cerium oxide nanoparticles (CeO2 NPs) have attracted increasing attention because of their unique antioxidant and antimicrobial properties. Here, this work designs a near-infrared (NIR) light-responsive gelatin methacryloyl (GelMA)/CeO2/polydopamine (PDA) hydrogel with antibacterial and antioxidant effects. The hydrogel exhibits a stable, efficient, and controllable photothermal conversion capacity under NIR stimulation. The hydrogel can be used to construct a local microenvironment conducive to chronic diabetic wound healing. Significant antibacterial effects of the NIR-responsive GelMA/CeO2/PDA hydrogel on both Escherichia coli (E.coli) and methicillin-resistant Staphylococcus aureus (MRSA) are demonstrated by counting colony-forming units (CFUs) and in bacterial live/dead staining experiments. The strong antioxidant activity of hydrogels is demonstrated by measuring the level of reactive oxygen species (ROS). The effect of the NIR-responsive GelMA/CeO2/PDA hydrogel in terms of promoting diabetic wound healing is validated in full-thickness cutaneous wounds of diabetic rat models. Additionally, this work describes the mechanism by which the NIR-responsive GelMA/CeO2/PDA hydrogel promotes diabetic wound healing; the hydrogel inhibits the interleukin (IL)-17 signaling pathway. This NIR-responsive, multifunctional hydrogel dressing provides a targeted approach to diabetic wound healing.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2402236"},"PeriodicalIF":10.0,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142941612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photo-Facilitated Nitric Oxide-Triggered Turn-on Photodynamic Therapy for Precise Antitumor Application. 光促进一氧化氮触发开启光动力疗法用于精确抗肿瘤应用。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-01-07 DOI: 10.1002/adhm.202404265

Yiliang Qin, Hanyi Gao, Yuting Yin, Jiayi Li, Xia He, Meng Gao, Liying Sun, Yi Yuan, Ying Tian, Yizhao Zhou, Zebing Zeng, Xiaodong Zhang, Rong Hu

{"title":"Photo-Facilitated Nitric Oxide-Triggered Turn-on Photodynamic Therapy for Precise Antitumor Application.","authors":"Yiliang Qin, Hanyi Gao, Yuting Yin, Jiayi Li, Xia He, Meng Gao, Liying Sun, Yi Yuan, Ying Tian, Yizhao Zhou, Zebing Zeng, Xiaodong Zhang, Rong Hu","doi":"10.1002/adhm.202404265","DOIUrl":"https://doi.org/10.1002/adhm.202404265","url":null,"abstract":"Photodynamic therapy (PDT) is a powerful strategy for tumor therapy with noninvasiveness and desirable efficacy. However, the phototoxicity of photosensitizer after the post-PDT is the major obstacle limiting the clinic applications. Herein, a nitric oxide (NO)-activatable photosensitizer is reported with turn-on PDT behavior and endoplasmic reticulum (ER) targeting ability for precise tumor therapy. Four o-thiophenediamine derivatives with reaction-tunable donor/acceptor push-pull electronic effect are established, and the systematic structure and property relationship observation reveals the following features: 1) the reactivity against NO can be improved by enhancing the electron density and further facilitated upon photo-irradiation. 2) the reactivity with NO enables the improved intramolecular charge transfer process with the evoking of photosensitizing effect. 3) only o-thiophenediamine derivative with ER enrichment behavior exhibited cancer cell ablation effect compared to photosensitizers localized in lysosome and lipid droplet. Thus, the efficient inhibition of cancer cells both in vitro and in vivo is realized based on the photo-controlled PDT strategy. This work provides more insights into developing promising activatable photosensitizers for advanced therapy based on tumor microenvironment trigger.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2404265"},"PeriodicalIF":10.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142941562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metal-Protein Hybrid Materials: Unlocking New Frontiers in Biomedical Applications. 金属-蛋白质混合材料：开启生物医学应用的新领域。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-01-07 DOI: 10.1002/adhm.202404405

Yong Pan, Han Zhao, Wenyong Huang, Siyang Liu, Yanxin Qi, Yubin Huang

{"title":"Metal-Protein Hybrid Materials: Unlocking New Frontiers in Biomedical Applications.","authors":"Yong Pan, Han Zhao, Wenyong Huang, Siyang Liu, Yanxin Qi, Yubin Huang","doi":"10.1002/adhm.202404405","DOIUrl":"https://doi.org/10.1002/adhm.202404405","url":null,"abstract":"Metal-protein hybrid materials represent a novel class of functional materials that exhibit exceptional physicochemical properties and tunable structures, rendering them remarkable applications in diverse fields, including materials engineering, biocatalysis, biosensing, and biomedicine. The design and development of multifunctional and biocompatible metal-protein hybrid materials have been the subject of extensive research and a key aspiration for practical applications in clinical settings. This review provides a comprehensive analysis of the design strategies, intrinsic properties, and biomedical applications of these hybrid materials, with a specific emphasis on their potential in cancer therapy, drug and vaccine delivery, antibacterial treatments, and tissue regeneration. Through rational design, stable metal-protein hybrid materials can be synthesized using straightforward methods, enabling them with therapeutic, delivery, immunomodulatory, and other desired functionalities. Finally, the review outlines the existing limitations and challenges associated with metal-protein hybrid materials and evaluates their potential for clinical translation, providing insights into their practical implementation within biomedical applications.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2404405"},"PeriodicalIF":10.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142941609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microwave-Sintered Nano-SiC Reinforced 8SiC/Ti-3Cu Composite: Fabrication, Wear Resistance, Antibacterial Function, and Biocompatibility. 微波烧结纳米碳化硅增强8SiC/Ti-3Cu复合材料：制备、耐磨性、抗菌功能和生物相容性。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-01-05 DOI: 10.1002/adhm.202403626

Xin Li, Ying-Chao Zhao, Dengfeng Yin, Ying Cai, Desheng Xiao, Ming-Chun Zhao, Cuie Wen, Andrej Atrens

{"title":"Microwave-Sintered Nano-SiC Reinforced 8SiC/Ti-3Cu Composite: Fabrication, Wear Resistance, Antibacterial Function, and Biocompatibility.","authors":"Xin Li, Ying-Chao Zhao, Dengfeng Yin, Ying Cai, Desheng Xiao, Ming-Chun Zhao, Cuie Wen, Andrej Atrens","doi":"10.1002/adhm.202403626","DOIUrl":"https://doi.org/10.1002/adhm.202403626","url":null,"abstract":"The significance of biomedical applications of Ti alloys is best emphasized by their widespread utilization as implantable materials, such as internal supports and bone replacements. Ti alloys are sensitive to fretting wear, which leads to the early failure of Ti implants. Improved wear resistance of such implants is essential to ensure a prolonged implant life. Based on the structure-function-integrated concept, this work unprecedentedly designs and fabricates an antibacterial 8SiC/Ti-3Cu composite with improved wear resistance using microwave sintering from pure Ti, Cu, and nano-SiC powders. For comparison, SiC-free Ti-3Cu composite is manufactured under the same conditions using microwave sintering. The addition of 8 vol.% SiC to Ti-3Cu significantly reduces the porosity and pore size of composites. The 8SiC/Ti-3Cu shows a Vickers hardness of 353 HV, compressive strength of 803 MPa, elastic modulus of 28.7 GPa, and a significantly increased wear resistance (wear rate decreased by 70% compared to Ti-3Cu). In addition, 8SiC/Ti-3Cu exhibits excellent electrochemical corrosion resistance, biocompatibility in relation to MC3T3-E1 cells, and a bacteriostatic rate over 99% against E. coli. The combination of the wear-resistant nano-reinforced SiC and antibacterial Ti2Cu in the 8SiC/Ti-3Cu composite renders it a highly promising implant material.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403626"},"PeriodicalIF":10.0,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Slimming/Excavating Strategy for Enhanced Intratumoral Penetration of Acid-Disassemblable NO-Releasing Nanomedicines. 一种增强酸可拆卸no释放纳米药物在肿瘤内渗透的减薄/挖掘策略。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-01-05 DOI: 10.1002/adhm.202404085

Lingdong Jiang, Anbang Wu, Lingting Zeng, Bin Zhou, Min Zhao, Mingjian Fan, Zhaokui Jin, Qianjun He

{"title":"A Slimming/Excavating Strategy for Enhanced Intratumoral Penetration of Acid-Disassemblable NO-Releasing Nanomedicines.","authors":"Lingdong Jiang, Anbang Wu, Lingting Zeng, Bin Zhou, Min Zhao, Mingjian Fan, Zhaokui Jin, Qianjun He","doi":"10.1002/adhm.202404085","DOIUrl":"https://doi.org/10.1002/adhm.202404085","url":null,"abstract":"Poor tumor penetration is the major predicament of nanomedicines that limits their anticancer efficacy. The dense extracellular matrix (ECM) in the tumor is one of the major barriers against the deep penetration of nanomedicines. In this work, a slimming/excavating strategy is proposed for enhanced intratumoral penetration based on an acid-disassemblable nanomicelles-assembled nanomedicine and the NO-mediated degradation of ECM. The nanomedicine is constructed by cross-linking nanomicelles, which are self-assembled with two kinds of dendrimers containing phenylboronic acid and lactobionic acid, through borate esterification. In the acidic tumor microenvironment, the pH-sensitive borate ester bonds among the nanomicelles are hydrolyzed, triggering the disassembly of nanomedicine (≈150 nm) into small nanomicelles (≈25 nm). In response to the intratumoral over-expressed glutathione (GSH), the NO donor loaded in the nanomicelles produces NO, which mediates the expression of matrix metalloproteinases for the degradation of ECM in the tumor. By collaboration of the disassembling behavior of nanomedicine with the NO-mediated degradation of ECM, the designed nanomedicine can penetrate a long distance in tumors. The proposed slimming/excavating strategy will provide inspiration for overcoming the challenge of nanomedicines in tumor penetration.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2404085"},"PeriodicalIF":10.0,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0