Advanced Healthcare Materials最新文献_第5页

Tissue-Engineered Therapeutics for Lymphatic Regeneration: Solutions for Myocardial Infarction and Secondary Lymphedema. 淋巴再生的组织工程疗法：心肌梗死和继发性淋巴水肿的解决方案。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-01-13 DOI: 10.1002/adhm.202403551

Alvis Chiu, Joseph M Rutkowski, Qixu Zhang, Feng Zhao

{"title":"Tissue-Engineered Therapeutics for Lymphatic Regeneration: Solutions for Myocardial Infarction and Secondary Lymphedema.","authors":"Alvis Chiu, Joseph M Rutkowski, Qixu Zhang, Feng Zhao","doi":"10.1002/adhm.202403551","DOIUrl":"https://doi.org/10.1002/adhm.202403551","url":null,"abstract":"The lymphatic system, which regulates inflammation and fluid homeostasis, is damaged in various diseases including myocardial infarction (MI) and breast-cancer-related lymphedema (BCRL). Mounting evidence suggests that restoring tissue fluid drainage and clearing excess immune cells by regenerating damaged lymphatic vessels can aid in cardiac repair and lymphedema amelioration. Current treatments primarily address symptoms rather than underlying causes due to a lack of regenerative therapies, highlighting the importance of the lymphatic system as a promising novel therapeutic target. Here cutting-edge research on engineered lymphatic tissues, growth factor therapies, and cell-based approaches designed to enhance lymphangiogenesis and restore lymphatic function is explored. Special focus is placed on how therapies with potential for immediate lymphatic reconstruction, originally designed for treating BCRL, can be applied to MI to augment cardiac repair and reduce heart failure risk. The integration of these novel treatments can significantly improve patient outcomes by promoting lymphatic repair, preventing pathological remodeling, and offering new avenues for managing lymphatic-associated diseases.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403551"},"PeriodicalIF":10.0,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142976745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumor-Resident Intracellular Bacteria Scavenger Activated In Situ Vaccines for Potent Cancer Photoimmunotherapy. 肿瘤细胞内细菌清除剂激活原位疫苗用于强效癌症光免疫治疗。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-01-13 DOI: 10.1002/adhm.202404271

Bai Lv, Yifan Zhao, Gang Li, Huimei Jiang, Min Zhang, Zequn Li, Jie Cao

{"title":"Tumor-Resident Intracellular Bacteria Scavenger Activated In Situ Vaccines for Potent Cancer Photoimmunotherapy.","authors":"Bai Lv, Yifan Zhao, Gang Li, Huimei Jiang, Min Zhang, Zequn Li, Jie Cao","doi":"10.1002/adhm.202404271","DOIUrl":"https://doi.org/10.1002/adhm.202404271","url":null,"abstract":"In situ tumor vaccines, which utilize antigens generated during tumor treatment to stimulate a cancer patient's immune system, has become a potential field in cancer immunotherapy. However, due to the immunosuppressive tumor microenvironment (ITME), the generation of tumor antigens is always mild and not sufficient. Tumor-resident intracellular bacteria have been identified as a complete tumor microenvironment component to contribute to creating ITME. Herein, a tumor-resident intracellular bacteria scavenger is designed to induce enhanced antitumor photoimmunotherapy-driven in situ vaccines for treating hypoxic tumors. This scavenger is developed by integrating photosensitizer CyI and antibiotics Doxycycline (Doxy) into thermal-sensitive tumor-derived exosomes fused liposomes (ECDL). In vitro and in vivo results showed that ECDL could homologous target to cancer cells and restrict the respiration of mitochondrial to reduce tumor hypoxia, thus providing continuous oxygen to eliminate both tumor cells and tumor-resident intracellular bacteria, which could induce in situ vaccines for ablating the primary tumor and inhibiting the tumor metastasis and recurrence. Moreover, eliminating tumor-resident intracellular bacteria neutralizes the ITME and triggers the production of bacterial-related neoantigens, which could further strength the immunotherapy. This study provided versatile and effective in situ vaccines that are promising for local, abscopal, and metastatic tumor treatment.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2404271"},"PeriodicalIF":10.0,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142976748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiscale Mechanical Study of Proanthocyanidins for Recovering Residual Stress in Decellularized Blood Vessels. 原花青素恢复脱细胞血管残余应力的多尺度力学研究。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-01-13 DOI: 10.1002/adhm.202402250

Yibo Han, Shuaiyuan Liu, Ben Omondi Ochieng, Yuanrui Gu, Lingwen Kong, Guixue Wang, Zhiyi Ye

{"title":"Multiscale Mechanical Study of Proanthocyanidins for Recovering Residual Stress in Decellularized Blood Vessels.","authors":"Yibo Han, Shuaiyuan Liu, Ben Omondi Ochieng, Yuanrui Gu, Lingwen Kong, Guixue Wang, Zhiyi Ye","doi":"10.1002/adhm.202402250","DOIUrl":"https://doi.org/10.1002/adhm.202402250","url":null,"abstract":"Decellularized artificial blood vessels prepared using physical and chemical methods often exhibit limitations, including poor mechanical performance, susceptibility to inflammation and calcification, and reduced patency. Cross-linking techniques can enhance the stiffness, as well as anti-inflammatory and anti-calcification properties of decellularized vessels. However, conventional cross-linking methods fail to effectively alleviate residual stress post-decellularization, which significantly impacts the patency and vascular remodeling following the implantation of artificial vessels. This study enhances vascular residual stress through varied conditions of proanthocyanidin (PC) cross-linking on decellularized vessels. Microstructural analysis and mechanical investigations across various scales of fresh, decellularized, and residual stress-recovered vessels are performed using atomic force microscopy (AFM), scanning electron microscopy (SEM), and uniaxial tensile testing. Results demonstrate substantial alterations in the morphology of elastic and collagen fibers post-decellularization, which remarkably resemble fresh vessels following residual stress recovery. Furthermore, both the micro- and macro-mechanical characteristics of vessels post-residual stress recovery, including Young's modulus, viscoelasticity, and adhesion, closely resemble those of fresh vessels. Finite element modeling (FEM) confirms the distribution of residual stress and its role in enhancing vascular mechanical integrity. This experimental investigation provides a theoretical foundation at both micro and macroscopic levels for the development of biomimetic blood vessels.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2402250"},"PeriodicalIF":10.0,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142968718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oncolytic Virus Targeted Therapy for Glioma via Intravenous Delivery. 溶瘤病毒静脉注射治疗胶质瘤

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-01-13 DOI: 10.1002/adhm.202404965

Yechenxing He, Wei Li, Xiaowei Zhang, Zongqiang Cui

{"title":"Oncolytic Virus Targeted Therapy for Glioma via Intravenous Delivery.","authors":"Yechenxing He, Wei Li, Xiaowei Zhang, Zongqiang Cui","doi":"10.1002/adhm.202404965","DOIUrl":"https://doi.org/10.1002/adhm.202404965","url":null,"abstract":"Glioma, the deadly primary intracranial tumor, poses challenges in clinical treatment due to its infiltrative growth and resistance to radiation. Oncolytic virus therapy holds potential for the treatment of malignant gliomas, but its application is impeded by the requirement for intracranial injections due to the presence of blood-brain barrier (BBB). In this study, to overcome this limitation, the study develops a nanocapsule encapsulating the recombinant oncolytic virus EV-A71-miR124T, enabling the treatment of glioma through intravenous administration. It is demonstrated that the nanocapsule can cross the BBB and selectively release oncolytic virus at the tumor site, resulting in targeted and specific killing of glioma cells. In mice with implanted intracranial orthotopic gliomas, intravenous administration of the nanocapsule suppresses tumor growth and significantly extends survival time. Consequently, the study establishes an effective treatment method for malignant gliomas using an oncolytic virus nanocapsule through intravenous administration. These findings provide a new strategy for oncolytic virus therapy in glioma treatment and offer perspectives for targeted therapies of other brain tumors and diseases.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2404965"},"PeriodicalIF":10.0,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142968724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Three-Level Nanoparticle Rocket Strategy for Colorectal Cancer Therapeutics in Photothermal Therapy, Inflammation Modulation, and Cuproptosis Induction. 三能级纳米粒子火箭策略在光热治疗、炎症调节和铜变诱导中用于结直肠癌治疗。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-01-10 DOI: 10.1002/adhm.202403939

Wenting Shang, Xueer Xia, Yuting Zhu, Qianyun Chen, Xi Rao, Ling Huang, Yingfeng Tu, Hao Chen, Hongxia Tian, Meiyin Lin, Yue Zheng, Bin Liu, Zhou Li, Shuai Han, Jianhua Liu

{"title":"Three-Level Nanoparticle Rocket Strategy for Colorectal Cancer Therapeutics in Photothermal Therapy, Inflammation Modulation, and Cuproptosis Induction.","authors":"Wenting Shang, Xueer Xia, Yuting Zhu, Qianyun Chen, Xi Rao, Ling Huang, Yingfeng Tu, Hao Chen, Hongxia Tian, Meiyin Lin, Yue Zheng, Bin Liu, Zhou Li, Shuai Han, Jianhua Liu","doi":"10.1002/adhm.202403939","DOIUrl":"https://doi.org/10.1002/adhm.202403939","url":null,"abstract":"Disturbances in intracellular copper (Cu) homeostasis can trigger cuproptosis, a new form of cell death, which, when combined with photothermal therapy (PTT), offers a promising solution to the persistent challenges in colorectal cancer (CRC) treatment. In this study, a \"three-level nanoparticle rocket\" strategy is developed by engineering Cu5.4O, a multifunctional Cu-based nanoenzyme that is photothermal and has electron transfer properties and antioxidant efficiency. Cu5.4O effectively remodels the inflammatory environment by scavenging reactive oxygen species, thereby overcoming the traditional limitations of PTT. Concurrently, Cu5.4O releases substantial amounts of Cu+ into malignant cells, disrupting Cu homeostasis, inducing cuproptosis, and ultimately inhibiting tumor progression. In vivo and in vitro experiments demonstrate that Cu5.4O operates through multiple successive and interlocking stages to significantly eradicate tumors, prevent relapse, and prolong survival. This study provides profound insights into the synergistic effects of PTT, inflammatory regulation, and cuproptosis within the complex tumor microenvironment, presenting innovative approaches for future CRC therapy.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403939"},"PeriodicalIF":10.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142941570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging Violet Phosphorus Nanomaterial for Biomedical Applications. 用于生物医学应用的紫磷纳米材料。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-01-10 DOI: 10.1002/adhm.202403576

Yijun Mei, Yuanyuan Cao, Wei Wang

{"title":"Emerging Violet Phosphorus Nanomaterial for Biomedical Applications.","authors":"Yijun Mei, Yuanyuan Cao, Wei Wang","doi":"10.1002/adhm.202403576","DOIUrl":"https://doi.org/10.1002/adhm.202403576","url":null,"abstract":"Violet phosphorus (VP) is a phosphorus allotrope first discovered by Hittorf in 1865, which has aroused more attention in the biomedical field in recent years attributed to its gradually discovered unique properties. VP can be further categorized into bulk VP, VP nanosheets (VPNs), and VP quantum dots (VPQDs), and chemical vapor transport (CVT), liquid-phase/mechanical/laser exfoliation, and solvothermal synthesis are the common preparation approaches of bulk VP, VPNs, and VPQDs, respectively. Compared with another phosphorus allotrope (black phosphorus, BP) that is once highly regarded in biomedical applications, VP nanomaterial (namely VPNs and VPQDs) not only exhibits tunable bandgap, moderate on/off current ratio, and good biodegradability, but shows enhanced stability and biosafety as well, allowing it to be a promising candidate for a variety of biomedical applications like antibacterial therapy, anticancer therapy, and biosensing and disease diagnosis. In this review, the classification and the relevant synthesis routes of VP are initially summarized, and the unique properties of VP nanomaterial momentous to its biomedical applications are subsequently expounded. The latest research advances of this emerging nanomaterial in the biomedical field are then introduced in detail, and both the existing challenges and future prospects are also discussed.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403576"},"PeriodicalIF":10.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142941590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electroactive Asymmetric Dressing for Spatiotemporal Deep Burn Scarless Healing and Management. 电活性非对称敷料在时空深度烧伤无瘢痕愈合与管理中的应用。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-01-10 DOI: 10.1002/adhm.202404266

Hanbai Wu, Xiong Zhou, Chuanwei Zhi, Cong Wang, Yuhan Chen, Yifan Si, Jieqiong Yang, Qi Zhang, Raymond H W Lam, Tingwu Qin, Guibing Fu, Zhu Xiong, Jinlian Hu

{"title":"Electroactive Asymmetric Dressing for Spatiotemporal Deep Burn Scarless Healing and Management.","authors":"Hanbai Wu, Xiong Zhou, Chuanwei Zhi, Cong Wang, Yuhan Chen, Yifan Si, Jieqiong Yang, Qi Zhang, Raymond H W Lam, Tingwu Qin, Guibing Fu, Zhu Xiong, Jinlian Hu","doi":"10.1002/adhm.202404266","DOIUrl":"https://doi.org/10.1002/adhm.202404266","url":null,"abstract":"Burn care and treatment differ markedly from other types of wounds, as they are significantly more prone to infections and struggle to maintain fluid balance post-burn. Moreover, the limited self-healing abilities exacerbate the likelihood of scar formation, further complicating the recovery process. To tackle these issues, an asymmetric wound dressing comprising a quercetin-loaded poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P34HB@Qu) hydrophilic layer and a zinc oxide nanoparticle-loaded, thermally treated polyvinylidene fluoride (HPVDF@ZnO) hydrophobic layer is designed. This dressing provided antibacterial property and exudate management in the early stages of burn treatment, preventing infection and maintaining moisture balance at the wound site. As healing progresses, the electroactive properties of HPVDF@ZnO and quercetin from P34HB@Qu synergistically regulate cell migration and differentiation, accelerating wound healing and facilitating scar-free regeneration. Furthermore, the wound dressing assisted in the regeneration of skin appendages. This study underscores the full-cycle strategy of versatile wound dressings for spatiotemporal burn wound management from injury to scarless healing.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2404266"},"PeriodicalIF":10.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasound-Triggered Oxygen Release System for Accelerating Wound Healing of Diabetic Foot Ulcers. 超声触发氧释放系统加速糖尿病足溃疡伤口愈合。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-01-10 DOI: 10.1002/adhm.202403224

Deli Zhuge, Siting Yang, Xiehua Pan, Yingnan Xiao, Xinji Wang, Wenqian Wang, Wenli Gao, Ailing Lu, Binbin Shi, Bin Chen, Yingzheng Zhao

引用次数: 0

Functional Hydrogel Interfaces for Cartilage and Bone Regeneration. 软骨和骨再生的功能性水凝胶界面。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-01-10 DOI: 10.1002/adhm.202403079

Yucheng Cao, Changyi Liu, Wenjun Ye, Tianrui Zhao, Fanfan Fu

引用次数: 0

Biomimetic Diselenide-Sonosensitizer Nanoplatform for Enhanced Sonodynamic Therapy and In Situ Remodeling Immunosuppressive Microenvironment via Activating Innate and Adaptive Immunotherapy. 通过激活先天免疫和适应性免疫治疗增强声动力治疗和原位重塑免疫抑制微环境的仿生双硒烯-声敏剂纳米平台。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-01-10 DOI: 10.1002/adhm.202403998

Yifan Xue, Qingliang Wang, You Chen, Xiaoge Zhang, Junjie Tang, Yadong Liu, Jie Liu

{"title":"Biomimetic Diselenide-Sonosensitizer Nanoplatform for Enhanced Sonodynamic Therapy and In Situ Remodeling Immunosuppressive Microenvironment via Activating Innate and Adaptive Immunotherapy.","authors":"Yifan Xue, Qingliang Wang, You Chen, Xiaoge Zhang, Junjie Tang, Yadong Liu, Jie Liu","doi":"10.1002/adhm.202403998","DOIUrl":"https://doi.org/10.1002/adhm.202403998","url":null,"abstract":"Sonodynamic therapy (SDT), which is non-invasive and controllable has the potential to treat triple-negative breast cancer (TNBC). However, the hypoxia and immunosuppressive tumor microenvironment (TME) often block the production of reactive oxygen species and the induction of SDT-activated immunogenic cell death, thus limiting the activation of adaptive immune responses. To alleviate these challenges, we proposed the development of a multifunctional biomimetic nanoplatform (mTSeIR), which was designed with diselenide-conjugated sonosensitizers and tirapazamine (TPZ), encapsulated within M1 macrophage membrane. This nanoplatform utilized hypoxia-induced chemotherapy to improve the efficacy of SDT, to further enhance adaptive immunotherapy by activating innate immunity and remodeling the immunosuppressive TME. Firstly, the prodrug TPZ was activated due to the increased oxygen consumption associated with SDT. Subsequently, the mTSeIR enhanced repolarization of M2 macrophages to the M1 phenotype. The diselenide component in mTSeIR effectively activated the natural killer cell-mediated antitumor innate immune response. Ultimately, in vivo studies indicated that mTSeIR+US with good biosafety achieved over 98% tumor inhibition and enhanced adaptive immunotherapy. This research presents an efficient approach that addressed the limitations of SDT and achieves simultaneous activation of both innate and adaptive immunotherapy, resulting in significant antitumor and anti-metastatic efficacy in TNBC.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403998"},"PeriodicalIF":10.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142941586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0