Advanced Healthcare Materials最新文献_第5页

Coupling Probiotics with CaO₂ Nanoparticle-Loaded CoFeCe-LDH Nanosheets to Remodel the Tumor Microenvironment for Precise Chemodynamic Therapy.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-08 DOI: 10.1002/adhm.202403373

Ruxue Si, Tingting Hu, Gareth R Williams, Yu Yang, Shuqing Yang, Dan Yan, Ruizheng Liang, Weiping Ji

{"title":"Coupling Probiotics with CaO2 Nanoparticle-Loaded CoFeCe-LDH Nanosheets to Remodel the Tumor Microenvironment for Precise Chemodynamic Therapy.","authors":"Ruxue Si, Tingting Hu, Gareth R Williams, Yu Yang, Shuqing Yang, Dan Yan, Ruizheng Liang, Weiping Ji","doi":"10.1002/adhm.202403373","DOIUrl":"https://doi.org/10.1002/adhm.202403373","url":null,"abstract":"Chemodynamic therapy (CDT) has become an emerging cancer treatment strategy with advantages of tumor-specificity, high selectivity, and low systemic toxicity. However, it usually suffers from low therapeutic efficacy. This is caused by low hydroxyl radical (·OH) yield arising because of the relatively high pH, overexpressed glutathione, and low H2O2 concentration in the tumor microenvironment (TME). Herein, a probiotic metabolism-initiated pH reduction and H2O2 supply-enhanced CDT strategy is reported to eradicate tumors by generating ·OH, in which Lactobacillus acidophilus is coupled with CoFeCe-layered double hydroxide nanosheets loaded with CaO2 nanoparticles (NPs) as a chemodynamic platform for high-efficiency CDT (CaO2/LDH@L. acidophilus). Owing to the hypoxia tropism of L. acidophilus, CaO2/LDH@L. acidophilus exhibits increased accumulation at tumor sites compared with the CaO2/LDH. The CaO2 NPs loaded on CoFeCe-LDH nanosheets are decomposed into H2O2 in the TME. L. acidophilus metabolite-induced pH reduction (<5.5) and CaO2-mediated in situ H2O2 generation synergistically boost ·OH generation activity of the CoFeCe-LDH nanosheets, effectively damaging cancer cells and ablating tumors with a tumor inhibition rate of 96.4%, 2.32-fold higher than that of CaO2/LDH. This work demonstrates that probiotics can function as a tumor-targeting platform to remodel the TME and amplify ROS generation for highly efficient and precise CDT.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403373"},"PeriodicalIF":10.0,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Embedded Bioprinting of Breast Cancer-Adipose Composite Tissue Model for Patient-Specific Paracrine Interaction Analysis.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-08 DOI: 10.1002/adhm.202401887

Wonwoo Jeong, Jonghyeuk Han, Jeonghan Choi, Hyun-Wook Kang

{"title":"Embedded Bioprinting of Breast Cancer-Adipose Composite Tissue Model for Patient-Specific Paracrine Interaction Analysis.","authors":"Wonwoo Jeong, Jonghyeuk Han, Jeonghan Choi, Hyun-Wook Kang","doi":"10.1002/adhm.202401887","DOIUrl":"https://doi.org/10.1002/adhm.202401887","url":null,"abstract":"The interaction between breast cancer and stromal tissues varies significantly from patient to patient, greatly impacting cancer prognosis. However, conventional models struggle to accurately replicate these patient-specific interactions. Herein, a novel breast cancer-adipose composite tissue model capable of precisely adjusting the inter-tissue interaction is developed. The composite tissue model is produced through precise embedded bioprinting of breast-cancer spheroids and live-adipose-tissue ink. This model possessed not only precisely patterned cancer spheroids but also well-preserved intrinsic extracellular matrices (ECMs) and heterogeneous cell populations of adipose tissue (AT). Evaluation results successfully demonstrated that the bioprinted composite model can precisely regulate adipokine secretion, drug resistance, and cancer-cell invasion characteristics by adjusting the distance between the cancer spheroids and adipose tissue. The utility of the model is validated using adipokine-targeted therapies (C-compound/SC600125 (SC), AG 490 (AG), and Metformin (MET)). Interestingly, the inhibition of cancer cell proliferation and invasion by these adipokine-targeted drugs nearly doubled as the tissue distance decreased. This suggests that the efficacy of the drugs can be precisely evaluated using the new model. These findings underscore the potential of the developed composite model to replicate patient-specific crosstalk, thereby offering a promising platform for the sophisticated evaluation of various breast-cancer therapies.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2401887"},"PeriodicalIF":10.0,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating 3D Bioprinting and Organoids to Better Recapitulate the Complexity of Cellular Microenvironments for Tissue Engineering.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-08 DOI: 10.1002/adhm.202403762

Yan Hu, Tong Zhu, Haitao Cui, Haijun Cui

{"title":"Integrating 3D Bioprinting and Organoids to Better Recapitulate the Complexity of Cellular Microenvironments for Tissue Engineering.","authors":"Yan Hu, Tong Zhu, Haitao Cui, Haijun Cui","doi":"10.1002/adhm.202403762","DOIUrl":"https://doi.org/10.1002/adhm.202403762","url":null,"abstract":"Organoids, with their capacity to mimic the structures and functions of human organs, have gained significant attention for simulating human pathophysiology and have been extensively investigated in the recent past. Additionally, 3D bioprinting, as an emerging bio-additive manufacturing technology, offers the potential for constructing heterogeneous cellular microenvironments, thereby promoting advancements in organoid research. In this review, the latest developments in 3D bioprinting technologies aimed at enhancing organoid engineering are introduced. The commonly used bioprinting methods and materials for organoids, with a particular emphasis on the potential advantages of combining 3D bioprinting with organoids are summarized. These advantages include achieving high cell concentrations to form large cellular aggregates, precise deposition of building blocks to create organoids with complex structures and functions, and automation and high throughput to ensure reproducibility and standardization in organoid culture. Furthermore, this review provides an overview of relevant studies from recent years and discusses the current limitations and prospects for future development.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403762"},"PeriodicalIF":10.0,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sulfasalazine-Loaded Copper-Tannic Acid Coordination Nanozyme Enables ROS Scavenging and Immunomodulation for Inflammatory Bowel Disease Therapy.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-08 DOI: 10.1002/adhm.202403738

Jian-Hua Yan, Chun-Xiao Liang, Ran-Ran Ma, Bo-Jia Li, Qi-Wen Chen, Wen Li, Xuan Zeng, Xian-Zheng Zhang

{"title":"Sulfasalazine-Loaded Copper-Tannic Acid Coordination Nanozyme Enables ROS Scavenging and Immunomodulation for Inflammatory Bowel Disease Therapy.","authors":"Jian-Hua Yan, Chun-Xiao Liang, Ran-Ran Ma, Bo-Jia Li, Qi-Wen Chen, Wen Li, Xuan Zeng, Xian-Zheng Zhang","doi":"10.1002/adhm.202403738","DOIUrl":"https://doi.org/10.1002/adhm.202403738","url":null,"abstract":"Inflammatory bowel disease (IBD) is associated with elevated levels of reactive oxygen species (ROS) and an increased expression of proinflammatory cytokines. Anti-inflammatory drugs, monoclonal antibodies, and immunomodulators are commonly employed to control the inflammatory response in the management of IBD. Here, a copper and tannic acid (TA) coordination nanozyme (CuTA) loaded with sulfasalazine (SSZ-CuTA) is synthesized for the treatment of IBD by simultaneous scavenging ROS and immunosuppression. The CuTA exhibits both dismutase-like activity and catalase-like activity, making it efficient at scavenging ROS. These nanozymes can efficiently traverse gastric acid and subsequently exert their effects within the intestinal tract. It is verified that SSZ-CuTA can restore intestinal mucosal and goblet cells to a healthy state by effectively eliminating ROS and reducing the pro-inflammatory factors in a mouse IBD model. Overall, the SSZ-CuTA will offer a promising alternative treatment for patients suffering from IBD where excessive ROS and high inflammation coexist.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403738"},"PeriodicalIF":10.0,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporary Nanoencapsulation of Human Intestinal Organoids Using Silk Ionomers.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-08 DOI: 10.1002/adhm.202403176

Brooke Wang, Onur Hasturk, Udathari Kumarasinghe, Sara Rudolph, Cristian Staii, Ying Chen, David L Kaplan

{"title":"Temporary Nanoencapsulation of Human Intestinal Organoids Using Silk Ionomers.","authors":"Brooke Wang, Onur Hasturk, Udathari Kumarasinghe, Sara Rudolph, Cristian Staii, Ying Chen, David L Kaplan","doi":"10.1002/adhm.202403176","DOIUrl":"https://doi.org/10.1002/adhm.202403176","url":null,"abstract":"Human intestinal organoids (HIOs) are vital for modeling intestinal development, disease, and therapeutic tissue regeneration. However, their susceptibility to stress, immunological attack, and environmental fluctuations limits their utility in research and therapeutic applications. This study evaluated the effectiveness of temporary silk protein-based layer-by-layer (LbL) nanoencapsulation technique to enhance the viability and functions of HIOs against common biomedical stressors, without compromising their native functions. Cell viability and differentiation capacity are assessed, finding that nanoencapsulation significantly improved HIO survival under the various environmental perturbations studied without compromising cellular functionality. Post-stress exposures, the encapsulated HIOs still successfully differentiated into essential intestinal cell types such as enterocytes, goblet cells, enteroendocrine cells, and Paneth cells. Moreover, the silk nanocoatings effectively protected against environmental stressors such as ultraviolet (UV) light exposure, protease degradation, antibody binding, and cytokine-induced inflammation. This nanoencapsulation technique shows promise for advancing HIO applications in disease modeling, drug testing, and potential transplantation therapies.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403176"},"PeriodicalIF":10.0,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Controlled Synthesis of the FeB Nanometallic Glasses with Stronger Electron Donating Capability to Activate Molecular Oxygen for the Enhanced Ferroptosis Therapy.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-08 DOI: 10.1002/adhm.202403582

Gongyu Shi, Yongxuan Zhang, Wenting Wang, Wanxuan Xiang, Feng Zhang, Xiaojiao Zhu, Hongping Zhou

{"title":"Controlled Synthesis of the FeB Nanometallic Glasses with Stronger Electron Donating Capability to Activate Molecular Oxygen for the Enhanced Ferroptosis Therapy.","authors":"Gongyu Shi, Yongxuan Zhang, Wenting Wang, Wanxuan Xiang, Feng Zhang, Xiaojiao Zhu, Hongping Zhou","doi":"10.1002/adhm.202403582","DOIUrl":"https://doi.org/10.1002/adhm.202403582","url":null,"abstract":"Considering the strong electron-donating ability and the superior biocompatibility, the integration of zero-valent iron nanostructure Fe0 (electron-reservoir) and zero-valent boron nanostructure B0 offers great promise for fabricating novel ferroptosis nanoagents. Nevertheless, the controlled and facile synthesis of alloyed Fe0 and B0 nanostructure-FeB nanometallic glasses (NMGs) has remained a long-standing challenge. Herein, a complexion-reduction strategy is proposed for the controlled synthesis of FeB NMGs with greater electron donating capacity to activate the molecular oxygen for improved ferroptosis therapy. In-depth mechanism reveales that the complexion-reduction strategy effectively prevent the long-range diffusion of Fe0, resulting in the amorphous alloyed Fe0 and B0 nanostructure-FeB nanoparticles (FeB NPs). The FeB NPs display stronger electron donating capability and electron transfer rate 9.4 times higher than that of the Fe0 NPs, which effectively activate the molecular oxygen to produce ∙O2 -, H2O2 and ∙OH. The in vitro cellular experiments confirm the FeB-ss-SiO₂ NPs (encapsulation with SiO2 outlayer containing -S-S- bonds) demonstrates the enhanced ferroptosis. The tumor-bearing mice models shows that FeB-ss-SiO₂ NPs exhibited superior biocompatibility and tumor inhibition effect (inhibition rate of 73%), which improve the overall survival rate for 30 days post-treatment. This study will provide an innovative way to design therapeutic nanoagents for cancer treatments.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403582"},"PeriodicalIF":10.0,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Probiotic-Based Mineralized Living Materials to Produce Antimicrobial Yogurts.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-08 DOI: 10.1002/adhm.202402793

Gloria B Ramírez-Rodríguez, Laura Sabio, Laura Cerezo-Collado, Víctor Garcés, Jose M Domínguez-Vera, José M Delgado-López

{"title":"Probiotic-Based Mineralized Living Materials to Produce Antimicrobial Yogurts.","authors":"Gloria B Ramírez-Rodríguez, Laura Sabio, Laura Cerezo-Collado, Víctor Garcés, Jose M Domínguez-Vera, José M Delgado-López","doi":"10.1002/adhm.202402793","DOIUrl":"https://doi.org/10.1002/adhm.202402793","url":null,"abstract":"Mineralization of living cells represents an evolutionary adaptation that enhances cellular resilience to physicochemical stress. Inspired by this strategy, we have here developed hybrid living materials (HLMs), incorporating probiotics into mineralized collagen 3D matrices, with the aim of protecting and promoting the successful oral delivery of the bacteria. Collagen fibrils are simultaneously self-assembled and mineralized in the presence of the probiotics (Lactobacillus acidophilus, La, was used as model), resulting in the integration of the probiotics into the hybrid matrix (i.e., bulk encapsulation). During this process, probiotics are also coated with a nanofilm of apatite mineral (single-cell encapsulation), which provides them with extra protection and reinforces their viability and activity. In fact, the resulting HLM is metabolically active, and maintain the capacity to ferment milk into yogurt with antibacterial activity against the two major foodborne pathogens Pseudomonas aeruginosa (Pa) and Staphylococcus aureus (Sa). Interestingly, the HLM provides probiotics an additional protection in the gastrointestinal environment (i.e., simulated gastric fluid), which is of special interest for healthcare materials for oral administration. The results pave the way for the creation of innovative healthcare materials with enhanced functionalities and the potential to produce probiotic foods with notable antimicrobial properties.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2402793"},"PeriodicalIF":10.0,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D-Bioprinting for Precision Microtissue Engineering: Advances, Applications, and Prospects.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-08 DOI: 10.1002/adhm.202403781

Jinrun Liu, Qi Wang, Yinpeng Le, Min Hu, Chen Li, Ni An, Qingru Song, Wenzhen Yin, Wenrui Ma, Mingyue Pan, Yutian Feng, Yunfang Wang, Lu Han, Juan Liu

{"title":"3D-Bioprinting for Precision Microtissue Engineering: Advances, Applications, and Prospects.","authors":"Jinrun Liu, Qi Wang, Yinpeng Le, Min Hu, Chen Li, Ni An, Qingru Song, Wenzhen Yin, Wenrui Ma, Mingyue Pan, Yutian Feng, Yunfang Wang, Lu Han, Juan Liu","doi":"10.1002/adhm.202403781","DOIUrl":"https://doi.org/10.1002/adhm.202403781","url":null,"abstract":"Microtissues, engineered to emulate the complexity of human organs, are revolutionizing the fields of regenerative medicine, disease modelling, and drug screening. Despite the promise of traditional microtissue engineering, it has yet to achieve the precision required to fully replicate organ-like structures. Enter 3D bioprinting, a transformative approach that offers unparalleled control over the microtissue's spatial arrangement and mechanical properties. This cutting-edge technology enables the detailed layering of bioinks, crafting microtissues with tissue-like 3D structures. It allows for the direct construction of organoids and the fine-tuning of the mechanical forces vital for tissue maturation. Moreover, 3D-printed devices provide microtissues with the necessary guidance and microenvironments, facilitating sophisticated tissue interactions. The applications of 3D-printed microtissues are expanding rapidly, with successful demonstrations of their functionality in vitro and in vivo. This technology excels at replicating the intricate processes of tissue development, offering a more ethical and controlled alternative to traditional animal models. By simulating in vivo conditions, 3D-printed microtissues are emerging as powerful tools for personalized drug screening, offering new avenues for pharmaceutical development and precision medicine.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2403781"},"PeriodicalIF":10.0,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mn and Zn-Doped Multivariate Metal-Organic Framework as a Metalloimmunological Adjuvant to Promote Protection Against Tuberculosis Infection.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-08 DOI: 10.1002/adhm.202402358

Thomas S Howlett, Sneha Kumari, Ryanne N Ehrman, Jesse Masson, Linda Izzo, Trixie Wang, Humera Gull, Ikeda Trashi, Wendy Tang, Orikeda Trashi, Neha Satish, Yalini H Wijesundara, Fabian C Herbert, Angelo A Izzo, Jeremiah J Gassensmith

{"title":"Mn and Zn-Doped Multivariate Metal-Organic Framework as a Metalloimmunological Adjuvant to Promote Protection Against Tuberculosis Infection.","authors":"Thomas S Howlett, Sneha Kumari, Ryanne N Ehrman, Jesse Masson, Linda Izzo, Trixie Wang, Humera Gull, Ikeda Trashi, Wendy Tang, Orikeda Trashi, Neha Satish, Yalini H Wijesundara, Fabian C Herbert, Angelo A Izzo, Jeremiah J Gassensmith","doi":"10.1002/adhm.202402358","DOIUrl":"https://doi.org/10.1002/adhm.202402358","url":null,"abstract":"A first-in-class vaccine adjuvant delivery system, Mn-ZIF, is developed by incorporating manganese (Mn) into the zinc-containing zeolitic-imidazolate framework-8 (ZIF-8). The mixed metal approach, which allowed for tunable Mn doping, is made possible by including a mild reducing agent in the reaction mixture. This approach allows up to 50% Mn, with the remaining 50% Zn within the ZIF. This multivariate approach exhibits significantly decreased cytotoxicity compared to ZIF-8. The porous structure of Mn-ZIF enables the co-delivery of the STING agonist cyclic di-adenosine monophosphate (CDA) through post-synthetic loading, forming CDA@Mn-ZIF. The composite demonstrated enhanced cellular uptake and synergistic activation of the cGAS-STING pathway, producing proinflammatory cytokines and activating antigen-presenting cells (APCs). In a preclinical Mycobacterium tuberculosis (Mtb) model, CDA@Mn-ZIF formulates with the CysVac2 fusion protein elicited a potent antigen-specific T-cell response and significantly reduced the mycobacterial burden in the lungs of infected mice. These findings highlight the potential of CDA@Mn-ZIF as a promising adjuvant for subunit vaccines, offering a novel approach to enhancing vaccine efficacy and protection against infectious diseases such as tuberculosis.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2402358"},"PeriodicalIF":10.0,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-Driven Janus Ga/Mg Micromotors for Reducing Deep Bacterial Infection in the Treatment of Periodontitis.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2024-12-08 DOI: 10.1002/adhm.202404303

Hang Chi, Wei Wu, Hongxia Bao, Yingjie Wu, Narisu Hu

{"title":"Self-Driven Janus Ga/Mg Micromotors for Reducing Deep Bacterial Infection in the Treatment of Periodontitis.","authors":"Hang Chi, Wei Wu, Hongxia Bao, Yingjie Wu, Narisu Hu","doi":"10.1002/adhm.202404303","DOIUrl":"https://doi.org/10.1002/adhm.202404303","url":null,"abstract":"A self-propulsion Janus gallium (Ga)/magnesium (Mg) bimetallic micromotor is designed with favorable biocompatibility and antimicrobial properties as a therapeutic strategy for periodontitis. The Janus Ga/Mg micromotors are fabricated by microcontact printing technique to asymmetrically modify liquid metallic gallium onto magnesium microspheres. Hydrogen bubbles produced by the magnesium-water reaction can provide the driving performance of up to 31.03 µm s-1 (pH 6.8), prompting the micromotor to actively breakthrough the biological barrier of saliva and gingival crevice fluid (GCF) into the bottom of periodontal pockets. In addition, the Janus Ga/Mg micromotors are effectively converted by degradation into the built-in antimicrobial ion Ga(III) to eliminate deep-seated Porphyromonas gingivalis (P.gingivalis), with bactericidal efficiencies of over 99.8%. The developed Janus Ga/Mg micromotors have demonstrated potent antimicrobial and anti-inflammatory activity both in vitro and in vivo studies. Crucially, it reduces alveolar bone resorption, demonstrating the superior efficacy of liquid metal gallium in treating periodontitis. Therefore, Ga/Mg bimetallic micromotors hold great promise to be an innovative and translational drug delivery system to treat periodontitis or other inflammation-related diseases in the near future.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2404303"},"PeriodicalIF":10.0,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0