Advanced Healthcare Materials最新文献_第5页

Membrane-Anchoring and Oxygen-Generating Mediated Nanosonosensitizer for Optimizing Cancer Immunotherapy.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-03-24 DOI: 10.1002/adhm.202404849

Qing Zhao, Ye Han, Wushuang Gong, Zhiyue Cao, Haonan Chang, Shaofan Gong, Qunying Li, Mengmeng Li, Chao Ma, Liangcan He, Hang Zhou

{"title":"Membrane-Anchoring and Oxygen-Generating Mediated Nanosonosensitizer for Optimizing Cancer Immunotherapy.","authors":"Qing Zhao, Ye Han, Wushuang Gong, Zhiyue Cao, Haonan Chang, Shaofan Gong, Qunying Li, Mengmeng Li, Chao Ma, Liangcan He, Hang Zhou","doi":"10.1002/adhm.202404849","DOIUrl":"https://doi.org/10.1002/adhm.202404849","url":null,"abstract":"Despite its antitumor promise, sonodynamic therapy (SDT)'s efficacy in immune activation requires enhancement, primarily due to the hypoxic tumor microenvironment (TME) and insufficient targeting of sonosensitizers to specific subcellular regions. Herein, we developed macrophage membrane (MM)-intermingled membrane fusogenic liposomes (MFL) to optimize sonoimmunotherapy that encapsulate catalase (CAT) within the core and incorporate the sonosensitizer chlorin e6 (Ce6) in the outer shell (CAT@MM-MFL-Ce6). The MM confers immune evasion properties and promotes nanoparticles' targeted accumulation in tumor tissue. The membrane fusion effect enables Ce6 to anchor onto cancer cell membrane and facilitates the direct delivery of CAT into the cytoplasm, bypassing endosomal degradation. Upon ultrasound stimulation, generated reactive oxygen species directly damage the plasma membrane, initiating the Caspase 3/Gasdermin E-mediated pyroptosis pathway. Concurrently, the encapsulated CAT efficiently decompose H₂O₂ in the cytoplasm, thus enhancing local oxygen levels in hypoxic tumors. Contributed by these effects, the combination of nanosonosensitizer-augmented SDT and immune checkpoint agent successfully reverse the immunosuppressive TME, driving a potent immune response that inhibits primary tumor growth, distant metastasis, and lung metastases in an orthotopic triple-negative breast cancer model. This study demonstrates the potential of a novel SDT-based combinatorial approach to modulate immune-cold TMEs, advancing proof-of-concept tumor therapeutics.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2404849"},"PeriodicalIF":10.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Porous Fe/Cu Nanoreactor with Dual Insurance Design for Precision Chemotherapy and Chemodynamic Therapy.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-03-24 DOI: 10.1002/adhm.202405229

Xianyu Zhu, Lingli Gao, Yanbo Zheng, Peng Fei Zhao, Hanrui Wei, Ruixue Liu, Liping Zhao, Junyi Zhang, Qi Sun, Lingling Zheng, Han Lv, JiGang Yang, Jianhua Gong, Zhenchang Wang

{"title":"Porous Fe/Cu Nanoreactor with Dual Insurance Design for Precision Chemotherapy and Chemodynamic Therapy.","authors":"Xianyu Zhu, Lingli Gao, Yanbo Zheng, Peng Fei Zhao, Hanrui Wei, Ruixue Liu, Liping Zhao, Junyi Zhang, Qi Sun, Lingling Zheng, Han Lv, JiGang Yang, Jianhua Gong, Zhenchang Wang","doi":"10.1002/adhm.202405229","DOIUrl":"https://doi.org/10.1002/adhm.202405229","url":null,"abstract":"Poor prognosis and chemotherapy response stem from difficulties in precise targeting and the lack of effective synergistic treatments. Nanozymes show promising potential in tumor chemodynamic therapy (CDT) by catalyzing hydrogen peroxide (H₂O₂) decomposition and glutathione depletion in the tumor microenvironment (TME). However, integrating precise chemotherapy targeting with CDT remains challenging. In this study, a porous Fe/Cu bimetallic nanozyme carrier (FeCuNPs) is developed for co-loading with the humanized 3F8 anti-GD2 disialoganglioside antibody (3F8) and the novel pyridazinone-based chemotherapeutic agent (IMB), forming a nanoreactor (3F8@FeCuNPs@IMB) for targeted chemotherapy and CDT. The nanoreactor responds specifically to the acidic TME as a primary insurance, allowing for the controlled release of IMB at the tumor site. The targeting antibody 3F8 coating on the surface of the nanozyme carrier acts as a secondary insurance, minimizing chemotherapy drug leakage during the delivery process and ensuring precise targeting for effective chemotherapy. Furthermore, FeCuNPs act as peroxidase-like (POD) and glutathione oxidase-like (GSHOX) enzymes, catalyzing hydroxyl radical (•OH) generation and depleting excess GSH, enhancing CDT. The results in vitro and in vivo indicate that the dual insurance designed 3F8@FeCuNPs@IMB offers a promising prospect for a targeted, precise, and effective combination of chemotherapy and CDT against melanoma.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2405229"},"PeriodicalIF":10.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prodigiosin Loaded SN-PB@PG NPs-Based Multimodal Therapy for the Healing of Bacterial Infected Chronic Wounds.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-03-23 DOI: 10.1002/adhm.202405100

Zhou Wu, Li Chang, Changling Li, Pengxiang Xu, Liuying Liu, Aidi Tong, Yilong Li, Chunyi Tong, Bin Liu

{"title":"Prodigiosin Loaded SN-PB@PG NPs-Based Multimodal Therapy for the Healing of Bacterial Infected Chronic Wounds.","authors":"Zhou Wu, Li Chang, Changling Li, Pengxiang Xu, Liuying Liu, Aidi Tong, Yilong Li, Chunyi Tong, Bin Liu","doi":"10.1002/adhm.202405100","DOIUrl":"https://doi.org/10.1002/adhm.202405100","url":null,"abstract":"Healing of infected chronic wounds faces dual challenges: persistent inflammation and impaired angiogenesis. To address these, SN-PB@PG nanocomplexes were prepared by hybridisation of nitroprusside (SNP) with Prussian blue (SN-PB NPs) and loaded with prodigiosin (PG). Under near-infrared (NIR) irradiation, SN-PB NPs generated mild hyperthermia, facilitating the release of nitric oxide (NO) and PG to combat bacterial biofilms and multidrug-resistant pathogens. The in vivo assay using diabetic infected wounds demonstrated that SN-PB@PG NPs with NIR reduced the wound area to 10.6% by the 11th day, which is superior to that of control group (29.6%). In the flap transplantation experiments, the data showed SN-PB@PG NPs with NIR group only have a necrobiosis of 3.8% of flaps on the 8th day, which is superior to 31.3% of the control group. Additionally, the release of NO promoted vascular regeneration by up-regulating vascular endothelial growth factor (VEGF) and platelet endothelial cell adhesion molecule-1 (CD31), and regenerated sarcomeric tissue by down-regulating MMP-9. The results indicated that the combination of SN-PB@PG NPs with gas and photothermal therapy exerted a combined antibacterial and wound healing effect. Compared to traditional clinical methods such as surgical debridement and hyperbaric oxygen therapy, this new strategy efficiently addresses issues of infection and healing, which is convenient for clinical application.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2405100"},"PeriodicalIF":10.0,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nano-Topography Enhanced Topological-Cell-Analysis in Radiation-Therapy.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-03-22 DOI: 10.1002/adhm.202405187

Francesca Pagliari, Maria-Francesca Spadea, Pierre Montay-Gruel, Anggraeini Puspitasari-Kokko, Joao Seco, Luca Tirinato, Angelo Accardo, Francesco De Angelis, Francesco Gentile

{"title":"Nano-Topography Enhanced Topological-Cell-Analysis in Radiation-Therapy.","authors":"Francesca Pagliari, Maria-Francesca Spadea, Pierre Montay-Gruel, Anggraeini Puspitasari-Kokko, Joao Seco, Luca Tirinato, Angelo Accardo, Francesco De Angelis, Francesco Gentile","doi":"10.1002/adhm.202405187","DOIUrl":"https://doi.org/10.1002/adhm.202405187","url":null,"abstract":"Radiotherapy (RT) is a cancer treatment technique that involves exposing cells to ionizing radiation, including X-rays, electrons, or protons. RT offers promise to treat cancer, however, some inherent limitations can hamper its performance. Radio-resistance, whether innate or acquired, refers to the ability of tumor cells to withstand treatment, making it a key factor in RT failure. This perspective hypothesizes that nanoscale surface topography can impact on the topology of cancer cells network under radiation, and that this understanding can possibly advance the assessment of cell radio-resistance in RT applications. An experimental plan is proposed to test this hypothesis, using cancer cells exposed to various RT forms. By examining the influence of 2D surface and 3D scaffold nanoscale architecture on cancer cells, this approach diverges from traditional methodologies, such as clonogenic assays, offering a novel viewpoint that integrates fields such as tissue engineering, artificial intelligence, and nanotechnology. The hypotheses at the base of this perspective not only may advance cancer treatment but also offers insights into the broader field of structural biology. Nanotechnology and label-free Raman phenotyping of biological samples are lenses through which scientists can possibly better elucidate the structure-function relationship in biological systems.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2405187"},"PeriodicalIF":10.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metal-Organic Frameworks for the Therapy of Inflammatory Diseases.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-03-21 DOI: 10.1002/adhm.202404334

Heng Zhao, Christian Serre, Nathalie Steunou

{"title":"Metal-Organic Frameworks for the Therapy of Inflammatory Diseases.","authors":"Heng Zhao, Christian Serre, Nathalie Steunou","doi":"10.1002/adhm.202404334","DOIUrl":"https://doi.org/10.1002/adhm.202404334","url":null,"abstract":"Inflammation is a natural immune response triggered by harmful external or internal stimuli. However, when inflammation fails to resolve and restore basal homeostasis, it can lead to various inflammatory diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and diabetic chronic wound (DCW). The modulation of inflammation follows a highly complex mechanism, and monotherapy is often insufficient for treating such conditions. Therefore, developing next-generation nanocarriers for anti-inflammatory drug delivery and multi-target combination therapies is critical. Metal-organic frameworks (MOFs), a class of porous coordination polymers with large surface areas and adaptable porosity, have emerged as promising drug delivery systems (DDS) due to their biodegradability, high drug loading capacity, stimuli-responsive drug release, and ease of functionalization. Over the past five years, MOFs have shown significant promise in treating inflammatory diseases, either as DDS or as intrinsic anti-inflammatory and anti-oxidative agents. Additionally, hybrid MOFs, which combine MOFs with nanozymes, offer a multifunctional anti-inflammatory platform with great potential. This review intends to provide a comprehensive review of the recent development of MOF-based nanomedicines for the therapy of inflammatory diseases. The challenges and future directions of research into the use of MOFs in the treatment of these diseases will also be discussed.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2404334"},"PeriodicalIF":10.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143672975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Progress on Antibacterial Applications of Bioactive Materials in Wound Infections: Design, Challenges, and Prospects. 生物活性材料在伤口感染中的抗菌应用研究进展：设计、挑战与前景》。

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-03-21 DOI: 10.1002/adhm.202405103

Wang Zheng, Yuanfang Cheng, Hui Shen, Litao Liu, Wei Hu, Haisheng Qian

引用次数: 0

Biomimetic Co-delivery of Lenvatinib and FePt Nanoparticles for Enhanced Ferroptosis/Apoptosis Treatment of Hepatocellular Carcinoma.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-03-21 DOI: 10.1002/adhm.202401747

Feichao Xuan, Xingyang Zhao, Weiran Pang, Zirong Li, Xiangyi Yin, Weizhong Xie, Xiaojun Zeng, Liming Nie, Junying Yang, Shiying Li, Puxiang Lai, Chihua Fang

{"title":"Biomimetic Co-delivery of Lenvatinib and FePt Nanoparticles for Enhanced Ferroptosis/Apoptosis Treatment of Hepatocellular Carcinoma.","authors":"Feichao Xuan, Xingyang Zhao, Weiran Pang, Zirong Li, Xiangyi Yin, Weizhong Xie, Xiaojun Zeng, Liming Nie, Junying Yang, Shiying Li, Puxiang Lai, Chihua Fang","doi":"10.1002/adhm.202401747","DOIUrl":"https://doi.org/10.1002/adhm.202401747","url":null,"abstract":"Lenvatinib, endorse as a first-line targeted therapy, has demonstrated efficacy in extending the survival span of individuals afflicted with advanced Hepatocellular carcinoma (HCC). However, its therapeutic effect wears off with time, which is ascribed to the cancer cell's tendency to evade and tamper with its usual modes of action, severely limiting its clinical use. This study devises an innovative therapeutic modality involving the synergistic co-delivery of FePt nanoparticles (NPs) and Lenvatinib via poly lactic-co-glycolic acid (PLGA) NPs encase in HCC cell membranes (Len/FePt@CMP NPs). The investigation explores the mechanism through which Lenvatinib induces ferroptosis in HCC, notably by dampening the glutathione peroxidase 4 (GPX4) through the inhibition of fibroblast growth factor receptor 4. FePt NPs are engineered to enhance the efficacy of ferroptosis and apoptosis for HCC treatment. Concurrently, the incorporation of the cancer cell membrane facilitates the targeted accumulation of NPs at the tumor site, leveraging mechanisms of immune evasion and homologous targeting. This enhances ferroptosis/apoptosis treatment efficacy, triggeres by Len/FePt@CMP NPs, is convincingly demonstrated both in vitro and in vivo. The proposed approach has the potential to redefine HCC therapeutic paradigms by overcoming mono-therapeutic limitations in current clinical treatments, showcasing the improved efficacy of a comprehensive strategy.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2401747"},"PeriodicalIF":10.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Expandable Brain-Machine Interface Enabled by Origami Materials and Structures for Tracking Epileptic Traveling Waves.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-03-20 DOI: 10.1002/adhm.202404947

Tiancheng Sheng, Jingwei Li, Lingyi Zheng, Nianzhen Du, Mingxiao Xie, Xiaolong Wang, Xize Gao, Mengsha Huang, Shenghan Wen, Wenqian Liu, Yong Guo, Yi Yao, Xiaoqiu Shao, Lianqing Liu, Jing Xu, Yilong Wang, Mingjun Zhang

引用次数: 0

Functionalized Cerium Oxide Nanoparticles Enhance Penetration into Melanoma Spheroids In Vivo through Angiogenesis.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-03-20 DOI: 10.1002/adhm.202405129

Lu Fu, Joel M Yong, Robyn Yeh, Florence Bartlett, John M Whitelock, Megan S Lord

{"title":"Functionalized Cerium Oxide Nanoparticles Enhance Penetration into Melanoma Spheroids In Vivo through Angiogenesis.","authors":"Lu Fu, Joel M Yong, Robyn Yeh, Florence Bartlett, John M Whitelock, Megan S Lord","doi":"10.1002/adhm.202405129","DOIUrl":"https://doi.org/10.1002/adhm.202405129","url":null,"abstract":"Angiogenesis is a crucial step in tumor progression, including melanoma, making anti-angiogenic strategies a widely explored treatment approach. However, both innate and acquired resistance to these therapies suggest that this approach may need re-evaluation. Nanoparticles have gained attention for their potential to enhance drug delivery and retention within tumors via the bloodstream. However, the in vitro screening of nanoparticles is limited by the inability of preclinical models to replicate the complex tumor microenvironment, especially the blood supply. Here, it is demonstrated that melanoma cells embedded in Matrigel spheroids can engraft in and be vascularized by the chorioallantoic membrane (CAM) of fertilized chicken eggs. This model allows for the assessment of nanoparticle toxicity and accumulation in tumor spheroids, as well as functional effects such as angiogenesis. Cerium oxide nanoparticles (nanoceria) and their surface functionalized derivatives are widely explored for biomedical applications due to their ability to modulate oxidative stress and angiogenesis. Here, it is observed that heparin functionalized nanoceria penetrate melanoma spheroids in the CAM and promote spheroid vascularization to a greater extent than nanoceria alone. This study aids in the development of preclinical cancer models for nanoparticle screening and provides new insight into the interplay between nanoparticle surface coatings and biological effects.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2405129"},"PeriodicalIF":10.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intrinsically Pro-Apoptotic Gold Nanoclusters for Optical Tracing and Inhibition of Solid Tumors.

IF 1 2区医学

Advanced Healthcare Materials Pub Date : 2025-03-20 DOI: 10.1002/adhm.202405005

Priyanka Sharma, Hao Yuan, Ruchi Verma, Nisha Mehla, Hemant Hemant, Poonam Sagar, Clothilde Comby-Zerbino, Isabelle Russier-Antoine, Christophe Moulin, Pierre-François Brevet, Nitin Singhal, Prakash P Neelakandan, Sonalika Vaidya, Changkui Fu, Md Ehesan Ali, Rohit Srivastava, Andrew Whittaker, Rodolphe Antoine, Asifkhan Shanavas

{"title":"Intrinsically Pro-Apoptotic Gold Nanoclusters for Optical Tracing and Inhibition of Solid Tumors.","authors":"Priyanka Sharma, Hao Yuan, Ruchi Verma, Nisha Mehla, Hemant Hemant, Poonam Sagar, Clothilde Comby-Zerbino, Isabelle Russier-Antoine, Christophe Moulin, Pierre-François Brevet, Nitin Singhal, Prakash P Neelakandan, Sonalika Vaidya, Changkui Fu, Md Ehesan Ali, Rohit Srivastava, Andrew Whittaker, Rodolphe Antoine, Asifkhan Shanavas","doi":"10.1002/adhm.202405005","DOIUrl":"https://doi.org/10.1002/adhm.202405005","url":null,"abstract":"Intrinsically theranostic metal nanoclusters are rare unless the stabilizing ligands exhibit therapeutic properties. A promising class of quasi-molecular, near-infrared (NIR) emitting, cytotoxic gold nanoclusters, coined as AXE (Au eXcitable and Eliminable) stabilized through terminal thioester groups on fluorinated, and crosslinked polymers, is presented for simultaneous bioimaging & therapy. Nano Variable Temperature-Electrospray ionization mass spectrometry analysis of these aqueous stable nanoclusters revealed 5 to 7 core gold atoms, with SAXS measurement confirming average size to be under 1 nm, consistent with the theoretical maximum for few atom planar gold clusters. Despite its small size, AXE exhibits a remarkable Stoke shift of ≈470 nm and emission range spanning 700 to 1100 nm. Fluorination notably enhanced the quantum yield by up to twofold, attributed to charge transfer from the fluorinated monomer to the gold core, as indicated by Löwdin charge distribution analysis. The AXE nanocluster demonstrated dose-dependent pro-apoptotic effects on cancer cells while sparing normal cells at lower concentrations. Preclinical evaluation in a breast tumor model confirmed its anticancer efficacy, with intravenous and intraperitoneal administrations significantly inhibiting tumor growth and controlling lung metastasis, surpassing the clinical standard, doxorubicin.","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":" ","pages":"e2405005"},"PeriodicalIF":10.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0