Encapsulation of Small Extracellular Vesicles into Selectively Disassemblable Shells of PEGylated Metal-Phenolic Networks (Adv. Healthcare Mater. 18/2025)

Abstract

Small Extracellular Vesicles

In article 2405188, Hirotaka Ejima and co-workers introduce a selectively disassemblable surface modification approach for small extracellular vesicles (sEVs) utilizing metal-phenolic networks that post-modified with polyethylene glycol. Such nanocoating significantly enhances the storage stability of sEVs and allows selectively triggered disassembly of encapsulated shells for the retrieval of intact and functional sEVs, thereby facilitating efficient storage, transport and subsequent promising biomedical applications.