An Expandable Silk Fibroin/Montmorillonite Porous Scaffolds Based on Clinical Dual Hemostasis Concept and Its Application in Bone Regeneration of Tooth Extraction Sockets with Coagulation Disorders.

IF 9.6 2区 医学 Q1 ENGINEERING, BIOMEDICAL
Menglin Xiao, Liangyan Sun, Hao Fu, Wenhua Yang, Jinrong Yao, Zhengzhong Shao, Shengjie Ling, Bingjiao Zhao, Xin Chen
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引用次数: 0

Abstract

With the global aging population and the rising incidence of cardiovascular diseases, the demand for long-term anticoagulant medication is increasing, leading to a higher risk of bleeding in medical fields such as oral surgery, particularly during tooth extractions. To address this clinical need, a convenient one-step method is developed to fabricate expandable silk fibroin/montmorillonite (SF/MMT) porous scaffolds by leveraging the procoagulant and osteogenic differentiation-promoting effects of montmorillonite (MMT), along with the biocompatibility of silk fibroin. The resulting SF/MMT porous scaffolds exhibit excellent shape recovery, with a volume expansion ratio of up to 400%. Furthermore, through the rapid blood absorption facilitated by the porous structure and the procoagulant effect of MMT, these scaffolds demonstrate superior hemostatic ability in both in vitro coagulation tests and in vivo rat tail amputation/liver laceration models. Finally, this expandable SF/MMT porous scaffolds used as hemostatic fillers showed significantly enhancement on bone regeneration in the tooth extraction socket of rat with coagulation disorders, outperforming commonly used gelatin sponges. In summary, this simple method for preparing expandable SF/MMT porous scaffolds addresses the challenge of managing post-extraction bleeding in patients on anticoagulant therapy and effectively promotes bone regeneration in extraction sockets, demonstrating considerable potential for application in stomatological clinic field.

基于临床双重止血理念的可膨胀丝素/蒙脱土多孔支架及其在凝血障碍拔牙槽骨再生中的应用
随着全球人口老龄化和心血管疾病发病率的上升,对长期抗凝药物的需求正在增加,导致口腔手术等医疗领域出血风险增加,特别是在拔牙过程中。为了满足这一临床需求,利用蒙脱土(MMT)的促凝和促骨分化作用,以及丝素蛋白的生物相容性,开发了一种便捷的一步法制作可膨胀丝素/蒙脱土(SF/MMT)多孔支架。所制得的SF/MMT多孔支架具有优异的形状恢复性能,其体积膨胀率高达400%。此外,通过MMT多孔结构的快速血液吸收和促凝作用,这些支架在体外凝血试验和大鼠断尾/肝裂伤模型中均表现出优异的止血能力。最后,这种可膨胀的SF/MMT多孔支架作为止血填充物,对凝血障碍大鼠拔牙槽骨再生的促进作用显著,优于常用的明胶海绵。综上所述,这种制备可膨胀的SF/MMT多孔支架的简单方法解决了抗凝治疗患者拔牙后出血的挑战,并有效地促进了拔牙槽骨的再生,在口腔临床领域具有很大的应用潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Advanced Healthcare Materials
Advanced Healthcare Materials 工程技术-生物材料
CiteScore
14.40
自引率
3.00%
发文量
600
审稿时长
1.8 months
期刊介绍: Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.
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