Jie Yu, Wenchang Xu, Huan Chen, Haitao Yuan, Yu Wang, Xiandie Qian, Jie Zhang, Yu Ji, Qi Zhao, Shengliang Li
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引用次数: 0
Abstract
Infection induced by multidrug-resistant bacteria is now the second most common cause of accidental death worldwide. However, identifying a high-performance strategy with good efficiency and low toxicity is still urgently needed. Antibacterial photodynamic therapy (PDT) is considered a non-invasive and efficient approach with minimal drug resistance. Whereas, the precise molecular design for highly efficient oxygen-independent type-I photosensitizers is still undefined. In this work, the regulation of the positive charge of star-shaped NIR-emissive organic photosensitizers can boost radical generation for the efficient treatment of wounds infected with multidrug-resistant bacteria. With positive charge engineering, TPAT-DNN, which has six positive charges, mainly produces hydroxyl radicals via the type-I pathway, while TPAT-DN, which has three positive charges, tends to generate singlet oxygen and superoxide radicals. For multidrug-resistant bacteria, TPAT-DNN exhibited specific killing effects on multidrug-resistant gram-positive bacteria at low concentrations, while TPAT-DN is similar antibacterial effects on both multidrug-resistant gram-negative and gram-positive bacteria. Furthermore, the efficiency and safety of TPAT-DNN for eradicating multidrug-resistant bacteria methicillin-resistant S. aureus (MRSA) infection and accelerating wound healing in an MRSA-infected mouse model are demonstrated. This work offers a new approach toward manipulating efficient type-I photosensitizers for MRSA treatment.
期刊介绍:
Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.