Therapeutic Implants: Mechanobiologic Enhancement of Osteogenic, Angiogenic, and Myogenic Responses in Human Mesenchymal Stem Cells on 3D-Printed Titanium Truss (Adv. Healthcare Mater. 27/2025)

IF 9.6 2区医学 Q1 ENGINEERING, BIOMEDICAL

Advanced Healthcare Materials Pub Date : 2025-10-21 DOI:10.1002/adhm.70265

Se-Hwan Lee, Ali Kiapour, Brendan D. Stoeckl, Ellen Y. Zhang, Matthew R. Begley, Jarod Oldham, Lewis Harrison, Jessee Hunt, Robert L. Mauck, Su Chin Heo

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Abstract

The Paradigm Shift to Orthopedic Implants with Therapeutic Effect

Legacy manufacturing technology limited the sophistication of orthopedic implant design and function. Additive manufacturing now provides the ability to produce implants with advanced structural designs. In contrast to the performance limitations of yesterday's static implants, today, kinetic implants can be produced that are programmed to provide a mechanical mode of action that converts physiologic load into therapeutic strain at the surgical site, amplifying osteogenic activity. The authors identify the synergistic effect between surface features, implant architecture, and mechanical environment, offering insights for optimizing next-generation orthopedic implants that provide a therapeutic effect and accelerate healing. More details can be found in the Research Article by Se-Hwan Lee, Ali Kiapour, and co-workers (DOI: 10.1002/adhm.202501856).

Abstract Image

查看原文本刊更多论文

治疗性植入物：3d打印钛桁架上人类间充质干细胞成骨、血管生成和肌生成反应的机械生物学增强（Adv. Healthcare Mater. 27/2025）

传统的制造技术限制了骨科植入物设计和功能的复杂性。增材制造现在提供了生产具有先进结构设计的植入物的能力。与过去静态植入物的性能限制相比，今天，动态植入物可以通过编程提供机械作用模式，将手术部位的生理负荷转化为治疗性应变，从而增强成骨活性。作者确定了表面特征、种植体结构和机械环境之间的协同效应，为优化下一代骨科种植体提供治疗效果和加速愈合提供了见解。更多细节可以在Se-Hwan Lee， Ali Kiapour及其同事的研究文章中找到（DOI: 10.1002/ admm .202501856）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Healthcare Materials 工程技术-生物材料

CiteScore

14.40

自引率

3.00%

发文量

600

审稿时长

1.8 months

期刊介绍： Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.