Therapeutic Implants: Mechanobiologic Enhancement of Osteogenic, Angiogenic, and Myogenic Responses in Human Mesenchymal Stem Cells on 3D-Printed Titanium Truss (Adv. Healthcare Mater. 27/2025)

The Paradigm Shift to Orthopedic Implants with Therapeutic Effect

Legacy manufacturing technology limited the sophistication of orthopedic implant design and function. Additive manufacturing now provides the ability to produce implants with advanced structural designs. In contrast to the performance limitations of yesterday's static implants, today, kinetic implants can be produced that are programmed to provide a mechanical mode of action that converts physiologic load into therapeutic strain at the surgical site, amplifying osteogenic activity. The authors identify the synergistic effect between surface features, implant architecture, and mechanical environment, offering insights for optimizing next-generation orthopedic implants that provide a therapeutic effect and accelerate healing. More details can be found in the Research Article by Se-Hwan Lee, Ali Kiapour, and co-workers (DOI: 10.1002/adhm.202501856).